EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000120688 (Gene tree)
Gene ID: 11193
Gene Symbol: WBP4
Alias: FBP21|MGC117310
Full Name: WW domain binding protein 4
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 22,733 bases
Position: chr13:41,061,274-41,084,006
Accession: 12739
RBP type: canonical RBP
Summary: This gene encodes WW domain-containing binding protein 4. The WW domain represents a small and compact globular structure that interacts with proline-rich ligands. This encoded protein is a general spliceosomal protein that may play a role in cross-intron bridging of U1 and U2 snRNPs in the spliceosomal complex A. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000368801	zf-U1	PF06220.12	2e-15	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
28402873	SAXS-Oriented Ensemble Refinement of Flexible Biomolecules.	Biophys J	2017 Apr 11	Cheng P	doi: 10.1016/j.bpj.2017.02.024.
28838205	A new role for FBP21 as regulator of Brr2 helicase activity.	Nucleic Acids Res	2017 Jul 27	Henning LM	doi: 10.1093/nar/gkx535.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000379487	WBP4-201	2623	XM_005266245	ENSP00000368801	376 (aa)	XP_005266302	O75554

Gene Model

Click here to download ENSG00000120688's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000120688	rs78169557	13	41081764	T	Intraocular pressure	29617998	[0.097-0.188] unit increase	0.1426	EFO_0004695

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000120688's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000120688	WBP4	99	43.807	ENSAPOG00000010206	-	99	45.116	Acanthochromis_polyacanthus
ENSG00000120688	WBP4	99	87.335	ENSAMEG00000008668	WBP4	99	87.335	Ailuropoda_melanoleuca
ENSG00000120688	WBP4	56	82.927	ENSACIG00000001515	-	99	82.927	Amphilophus_citrinellus
ENSG00000120688	WBP4	99	43.880	ENSAOCG00000002831	-	99	44.804	Amphiprion_ocellaris
ENSG00000120688	WBP4	99	43.880	ENSAPEG00000014824	-	99	44.186	Amphiprion_percula
ENSG00000120688	WBP4	99	51.157	ENSAPLG00000009035	WBP4	99	48.522	Anas_platyrhynchos
ENSG00000120688	WBP4	100	50.636	ENSACAG00000000798	WBP4	100	50.256	Anolis_carolinensis
ENSG00000120688	WBP4	100	95.213	ENSANAG00000028222	WBP4	100	95.213	Aotus_nancymaae
ENSG00000120688	WBP4	62	68.627	ENSACLG00000016300	-	89	68.627	Astatotilapia_calliptera
ENSG00000120688	WBP4	99	43.810	ENSACLG00000023922	-	99	43.571	Astatotilapia_calliptera
ENSG00000120688	WBP4	100	80.402	ENSBTAG00000016637	WBP4	100	80.402	Bos_taurus
ENSG00000120688	WBP4	100	94.149	ENSCJAG00000017768	WBP4	100	94.149	Callithrix_jacchus
ENSG00000120688	WBP4	100	87.766	ENSCAFG00000004805	WBP4	100	87.766	Canis_familiaris
ENSG00000120688	WBP4	100	87.766	ENSCAFG00020018156	WBP4	100	87.766	Canis_lupus_dingo
ENSG00000120688	WBP4	99	82.857	ENSCHIG00000013146	WBP4	100	82.857	Capra_hircus
ENSG00000120688	WBP4	100	89.096	ENSTSYG00000000055	WBP4	100	89.096	Carlito_syrichta
ENSG00000120688	WBP4	99	78.042	ENSCPOG00000013860	WBP4	99	79.112	Cavia_porcellus
ENSG00000120688	WBP4	100	94.681	ENSCCAG00000024682	WBP4	100	94.681	Cebus_capucinus
ENSG00000120688	WBP4	100	96.809	ENSCATG00000035168	WBP4	100	96.809	Cercocebus_atys
ENSG00000120688	WBP4	99	81.600	ENSCLAG00000002494	WBP4	99	82.133	Chinchilla_lanigera
ENSG00000120688	WBP4	100	96.543	ENSCSAG00000017836	WBP4	100	96.543	Chlorocebus_sabaeus
ENSG00000120688	WBP4	81	50.492	ENSCHOG00000009432	-	100	50.492	Choloepus_hoffmanni
ENSG00000120688	WBP4	100	48.995	ENSCPBG00000007957	WBP4	100	47.433	Chrysemys_picta_bellii
ENSG00000120688	WBP4	100	96.011	ENSCANG00000034119	WBP4	100	96.011	Colobus_angolensis_palliatus
ENSG00000120688	WBP4	100	79.894	ENSCGRG00001002031	Wbp4	100	79.894	Cricetulus_griseus_chok1gshd
ENSG00000120688	WBP4	99	79.841	ENSCGRG00000001346	Wbp4	100	79.841	Cricetulus_griseus_crigri
ENSG00000120688	WBP4	99	41.608	ENSCSEG00000005673	-	99	42.217	Cynoglossus_semilaevis
ENSG00000120688	WBP4	99	42.157	ENSCVAG00000021735	-	99	41.646	Cyprinodon_variegatus
ENSG00000120688	WBP4	100	77.394	ENSDNOG00000046013	WBP4	100	79.255	Dasypus_novemcinctus
ENSG00000120688	WBP4	100	72.222	ENSDORG00000007755	Wbp4	100	73.016	Dipodomys_ordii
ENSG00000120688	WBP4	100	89.894	ENSEASG00005015706	WBP4	100	89.894	Equus_asinus_asinus
ENSG00000120688	WBP4	100	89.894	ENSECAG00000021033	WBP4	100	89.894	Equus_caballus
ENSG00000120688	WBP4	56	60.811	ENSELUG00000006526	-	79	72.000	Esox_lucius
ENSG00000120688	WBP4	100	88.830	ENSFCAG00000035581	WBP4	100	88.298	Felis_catus
ENSG00000120688	WBP4	99	48.411	ENSFALG00000008022	WBP4	99	48.756	Ficedula_albicollis
ENSG00000120688	WBP4	99	72.679	ENSFDAG00000018896	WBP4	100	72.679	Fukomys_damarensis
ENSG00000120688	WBP4	99	44.198	ENSFHEG00000019032	-	99	43.237	Fundulus_heteroclitus
ENSG00000120688	WBP4	55	76.744	ENSGMOG00000008593	-	52	76.744	Gadus_morhua
ENSG00000120688	WBP4	100	50.120	ENSGALG00000016949	WBP4	100	50.120	Gallus_gallus
ENSG00000120688	WBP4	99	42.890	ENSGAFG00000007099	-	99	42.890	Gambusia_affinis
ENSG00000120688	WBP4	99	43.521	ENSGACG00000013725	-	99	45.588	Gasterosteus_aculeatus
ENSG00000120688	WBP4	100	48.537	ENSGAGG00000003736	WBP4	100	49.620	Gopherus_agassizii
ENSG00000120688	WBP4	100	99.202	ENSGGOG00000026935	WBP4	100	99.202	Gorilla_gorilla
ENSG00000120688	WBP4	99	44.524	ENSHBUG00000020880	-	99	44.286	Haplochromis_burtoni
ENSG00000120688	WBP4	99	82.133	ENSHGLG00000004585	WBP4	100	81.867	Heterocephalus_glaber_female
ENSG00000120688	WBP4	81	80.719	ENSHGLG00100001393	WBP4	100	80.392	Heterocephalus_glaber_male
ENSG00000120688	WBP4	99	42.959	ENSHCOG00000009465	-	99	42.959	Hippocampus_comes
ENSG00000120688	WBP4	99	45.202	ENSIPUG00000004525	wbp4	99	44.643	Ictalurus_punctatus
ENSG00000120688	WBP4	100	86.702	ENSSTOG00000024976	WBP4	100	86.702	Ictidomys_tridecemlineatus
ENSG00000120688	WBP4	100	81.649	ENSJJAG00000014406	Wbp4	100	81.649	Jaculus_jaculus
ENSG00000120688	WBP4	99	43.192	ENSKMAG00000003209	-	99	42.857	Kryptolebias_marmoratus
ENSG00000120688	WBP4	99	45.220	ENSLBEG00000023027	-	99	43.990	Labrus_bergylta
ENSG00000120688	WBP4	99	41.435	ENSLBEG00000027158	-	99	41.667	Labrus_bergylta
ENSG00000120688	WBP4	100	49.505	ENSLACG00000008754	WBP4	100	49.505	Latimeria_chalumnae
ENSG00000120688	WBP4	99	45.750	ENSLOCG00000005967	WBP4	99	46.250	Lepisosteus_oculatus
ENSG00000120688	WBP4	99	80.267	ENSLAFG00000005901	WBP4	99	80.267	Loxodonta_africana
ENSG00000120688	WBP4	100	96.809	ENSMFAG00000034268	WBP4	100	96.809	Macaca_fascicularis
ENSG00000120688	WBP4	100	96.809	ENSMMUG00000007881	WBP4	100	96.809	Macaca_mulatta
ENSG00000120688	WBP4	100	96.809	ENSMNEG00000039992	WBP4	100	96.809	Macaca_nemestrina
ENSG00000120688	WBP4	100	97.074	ENSMLEG00000036795	WBP4	100	97.074	Mandrillus_leucophaeus
ENSG00000120688	WBP4	99	44.976	ENSMAMG00000022052	-	99	45.606	Mastacembelus_armatus
ENSG00000120688	WBP4	99	43.810	ENSMZEG00005017926	-	99	43.571	Maylandia_zebra
ENSG00000120688	WBP4	99	52.030	ENSMGAG00000014970	WBP4	99	51.662	Meleagris_gallopavo
ENSG00000120688	WBP4	100	79.365	ENSMAUG00000018253	Wbp4	100	79.365	Mesocricetus_auratus
ENSG00000120688	WBP4	100	87.302	ENSMICG00000047481	WBP4	100	90.476	Microcebus_murinus
ENSG00000120688	WBP4	100	79.894	ENSMOCG00000012721	Wbp4	100	80.159	Microtus_ochrogaster
ENSG00000120688	WBP4	73	42.606	ENSMMOG00000013396	-	62	54.255	Mola_mola
ENSG00000120688	WBP4	100	64.691	ENSMODG00000014761	WBP4	100	65.464	Monodelphis_domestica
ENSG00000120688	WBP4	99	43.294	ENSMALG00000013252	-	99	44.575	Monopterus_albus
ENSG00000120688	WBP4	100	77.984	MGP_CAROLIEiJ_G0019542	Wbp4	100	77.719	Mus_caroli
ENSG00000120688	WBP4	100	78.100	ENSMUSG00000022023	Wbp4	100	78.100	Mus_musculus
ENSG00000120688	WBP4	100	77.836	MGP_SPRETEiJ_G0020437	Wbp4	100	77.836	Mus_spretus
ENSG00000120688	WBP4	100	88.298	ENSMPUG00000001879	WBP4	100	88.298	Mustela_putorius_furo
ENSG00000120688	WBP4	99	86.667	ENSMLUG00000001855	WBP4	99	86.667	Myotis_lucifugus
ENSG00000120688	WBP4	100	82.447	ENSNGAG00000024369	Wbp4	100	81.915	Nannospalax_galili
ENSG00000120688	WBP4	99	44.286	ENSNBRG00000004655	-	99	44.286	Neolamprologus_brichardi
ENSG00000120688	WBP4	100	91.489	ENSNLEG00000001220	WBP4	100	91.489	Nomascus_leucogenys
ENSG00000120688	WBP4	100	57.963	ENSMEUG00000015983	WBP4	100	57.330	Notamacropus_eugenii
ENSG00000120688	WBP4	100	65.517	ENSOPRG00000015589	-	83	86.170	Ochotona_princeps
ENSG00000120688	WBP4	81	77.524	ENSODEG00000005811	WBP4	100	76.221	Octodon_degus
ENSG00000120688	WBP4	99	44.963	ENSONIG00000012474	-	99	46.500	Oreochromis_niloticus
ENSG00000120688	WBP4	100	79.581	ENSOCUG00000004256	WBP4	100	82.152	Oryctolagus_cuniculus
ENSG00000120688	WBP4	99	41.176	ENSORLG00000003254	-	99	40.941	Oryzias_latipes
ENSG00000120688	WBP4	99	41.686	ENSORLG00020021034	-	99	41.509	Oryzias_latipes_hni
ENSG00000120688	WBP4	99	41.531	ENSORLG00015020983	-	99	42.056	Oryzias_latipes_hsok
ENSG00000120688	WBP4	99	85.185	ENSOGAG00000015224	WBP4	100	86.772	Otolemur_garnettii
ENSG00000120688	WBP4	100	80.151	ENSOARG00000006905	WBP4	100	80.905	Ovis_aries
ENSG00000120688	WBP4	100	99.202	ENSPPAG00000034971	WBP4	100	99.202	Pan_paniscus
ENSG00000120688	WBP4	100	88.298	ENSPPRG00000009978	WBP4	100	87.766	Panthera_pardus
ENSG00000120688	WBP4	99	88.000	ENSPTIG00000003187	WBP4	93	87.467	Panthera_tigris_altaica
ENSG00000120688	WBP4	100	99.202	ENSPTRG00000005812	WBP4	100	99.202	Pan_troglodytes
ENSG00000120688	WBP4	100	97.074	ENSPANG00000016720	WBP4	100	97.074	Papio_anubis
ENSG00000120688	WBP4	99	44.366	ENSPKIG00000013409	-	99	44.988	Paramormyrops_kingsleyae
ENSG00000120688	WBP4	99	53.927	ENSPSIG00000006270	WBP4	99	53.018	Pelodiscus_sinensis
ENSG00000120688	WBP4	99	38.847	ENSPMGG00000006726	-	99	37.975	Periophthalmus_magnuspinnatus
ENSG00000120688	WBP4	100	79.948	ENSPEMG00000021764	Wbp4	100	80.208	Peromyscus_maniculatus_bairdii
ENSG00000120688	WBP4	69	58.303	ENSPCIG00000026104	-	69	71.066	Phascolarctos_cinereus
ENSG00000120688	WBP4	100	65.641	ENSPCIG00000012936	-	99	65.128	Phascolarctos_cinereus
ENSG00000120688	WBP4	99	41.935	ENSPFOG00000000295	-	99	43.091	Poecilia_formosa
ENSG00000120688	WBP4	99	42.263	ENSPLAG00000014276	-	99	43.427	Poecilia_latipinna
ENSG00000120688	WBP4	99	41.705	ENSPMEG00000023239	-	99	42.857	Poecilia_mexicana
ENSG00000120688	WBP4	99	41.972	ENSPREG00000018630	-	99	43.590	Poecilia_reticulata
ENSG00000120688	WBP4	100	98.670	ENSPPYG00000005310	WBP4	100	98.670	Pongo_abelii
ENSG00000120688	WBP4	100	86.436	ENSPVAG00000014634	WBP4	100	86.170	Pteropus_vampyrus
ENSG00000120688	WBP4	99	43.560	ENSPNYG00000004384	-	99	43.326	Pundamilia_nyererei
ENSG00000120688	WBP4	68	48.289	ENSPNAG00000010658	-	89	47.710	Pygocentrus_nattereri
ENSG00000120688	WBP4	100	77.719	ENSRNOG00000011678	Wbp4	100	77.188	Rattus_norvegicus
ENSG00000120688	WBP4	100	93.351	ENSRBIG00000041962	WBP4	100	93.351	Rhinopithecus_bieti
ENSG00000120688	WBP4	100	97.606	ENSRROG00000044405	WBP4	100	97.606	Rhinopithecus_roxellana
ENSG00000120688	WBP4	77	93.750	ENSSBOG00000026978	WBP4	92	93.750	Saimiri_boliviensis_boliviensis
ENSG00000120688	WBP4	99	62.435	ENSSHAG00000018027	WBP4	99	65.803	Sarcophilus_harrisii
ENSG00000120688	WBP4	99	44.903	ENSSFOG00015006208	wbp4	99	44.048	Scleropages_formosus
ENSG00000120688	WBP4	99	42.155	ENSSMAG00000015714	-	99	43.396	Scophthalmus_maximus
ENSG00000120688	WBP4	99	44.844	ENSSLDG00000013599	-	99	44.365	Seriola_lalandi_dorsalis
ENSG00000120688	WBP4	100	51.768	ENSSPUG00000007329	WBP4	100	51.010	Sphenodon_punctatus
ENSG00000120688	WBP4	99	42.032	ENSSPAG00000000884	-	99	42.824	Stegastes_partitus
ENSG00000120688	WBP4	100	86.968	ENSSSCG00000031627	WBP4	100	86.968	Sus_scrofa
ENSG00000120688	WBP4	99	50.369	ENSTGUG00000012433	WBP4	100	50.250	Taeniopygia_guttata
ENSG00000120688	WBP4	99	41.608	ENSTNIG00000017150	-	99	41.706	Tetraodon_nigroviridis
ENSG00000120688	WBP4	100	87.632	ENSTTRG00000010342	WBP4	100	87.632	Tursiops_truncatus
ENSG00000120688	WBP4	100	88.564	ENSUAMG00000009847	WBP4	100	88.564	Ursus_americanus
ENSG00000120688	WBP4	100	88.564	ENSUMAG00000014750	WBP4	100	88.564	Ursus_maritimus
ENSG00000120688	WBP4	81	73.443	ENSVPAG00000002053	WBP4	100	73.443	Vicugna_pacos
ENSG00000120688	WBP4	67	89.683	ENSVVUG00000028761	WBP4	88	89.683	Vulpes_vulpes
ENSG00000120688	WBP4	99	49.610	ENSXETG00000018896	wbp4	100	49.219	Xenopus_tropicalis
ENSG00000120688	WBP4	99	41.570	ENSXMAG00000029739	-	99	42.558	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000398	mRNA splicing, via spliceosome	28781166.	IDA	Process
GO:0000398	mRNA splicing, via spliceosome	-	TAS	Process
GO:0003676	nucleic acid binding	-	IEA	Function
GO:0005515	protein binding	17500595.28838205.	IPI	Function
GO:0005634	nucleus	28781166.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0008270	zinc ion binding	-	IEA	Function
GO:0016607	nuclear speck	19592703.	IDA	Component
GO:0045292	mRNA cis splicing, via spliceosome	19592703.	IDA	Process
GO:0070064	proline-rich region binding	19592703.	IPI	Function
GO:0071005	U2-type precatalytic spliceosome	28781166.	IDA	Component