EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000120805 (Gene tree)
Gene ID: 400
Gene Symbol: ARL1
Alias: ARFL1
Full Name: ADP ribosylation factor like GTPase 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 14,701 bases
Position: chr12:101,393,120-101,407,820
Accession: 692
RBP type: canonical RBP
Summary: The protein encoded by this gene belongs to the ARL (ADP-ribosylation factor-like) family of proteins, which are structurally related to ADP-ribosylation factors (ARFs). ARFs, described as activators of cholera toxin (CT) ADP-ribosyltransferase activity, regulate intracellular vesicular membrane trafficking, and stimulate a phospholipase D (PLD) isoform. Although, ARL proteins were initially thought not to activate CT or PLD, later work showed that they are weak stimulators of PLD and CT in a phospholipid dependent manner. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000441808	MMR_HSR1	PF01926.23	0.00019	1	1
ENSP00000448850	MMR_HSR1	PF01926.23	0.00019	1	1
ENSP00000261636	MMR_HSR1	PF01926.23	0.00024	1	1
ENSP00000448912	MMR_HSR1	PF01926.23	0.0003	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000549283	ARL1-205	566	-	-	- (aa)	-	-
ENST00000551828	ARL1-211	776	-	ENSP00000448850	164 (aa)	-	P40616
ENST00000539055	ARL1-203	1231	-	ENSP00000439590	135 (aa)	-	B4DZG7
ENST00000551688	ARL1-210	470	-	ENSP00000447405	52 (aa)	-	F8W1Z8
ENST00000261636	ARL1-201	3241	-	ENSP00000261636	181 (aa)	-	P40616
ENST00000536227	ARL1-202	1322	-	ENSP00000441808	164 (aa)	-	P40616
ENST00000551671	ARL1-209	879	-	ENSP00000448912	194 (aa)	-	F8VYN9
ENST00000550597	ARL1-207	768	-	-	- (aa)	-	-
ENST00000549302	ARL1-206	725	-	-	- (aa)	-	-
ENST00000548070	ARL1-204	590	-	ENSP00000450315	17 (aa)	-	F8VP99
ENST00000551092	ARL1-208	731	-	ENSP00000450162	64 (aa)	-	F8VP63

Gene Model

Click here to download ENSG00000120805's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000120805's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000120805	ARL1	100	93.293	ENSAPOG00000002469	arl1	95	93.413	Acanthochromis_polyacanthus
ENSG00000120805	ARL1	100	98.780	ENSAMEG00000016452	ARL1	99	98.889	Ailuropoda_melanoleuca
ENSG00000120805	ARL1	100	91.463	ENSACIG00000007953	arl1	93	91.617	Amphilophus_citrinellus
ENSG00000120805	ARL1	100	93.293	ENSAOCG00000013008	arl1	92	93.413	Amphiprion_ocellaris
ENSG00000120805	ARL1	100	93.293	ENSAPEG00000013187	arl1	95	93.413	Amphiprion_percula
ENSG00000120805	ARL1	100	94.512	ENSATEG00000005559	arl1	90	94.611	Anabas_testudineus
ENSG00000120805	ARL1	100	96.341	ENSAPLG00000016092	ARL1	92	96.407	Anas_platyrhynchos
ENSG00000120805	ARL1	100	97.561	ENSACAG00000011602	ARL1	100	97.238	Anolis_carolinensis
ENSG00000120805	ARL1	100	99.448	ENSANAG00000023491	ARL1	100	99.448	Aotus_nancymaae
ENSG00000120805	ARL1	100	93.902	ENSACLG00000008188	arl1	92	94.012	Astatotilapia_calliptera
ENSG00000120805	ARL1	100	95.732	ENSAMXG00000021056	arl1	96	95.808	Astyanax_mexicanus
ENSG00000120805	ARL1	100	99.448	ENSBTAG00000011883	ARL1	100	99.448	Bos_taurus
ENSG00000120805	ARL1	100	73.171	WBGene00000187	arl-1	93	73.054	Caenorhabditis_elegans
ENSG00000120805	ARL1	100	99.448	ENSCJAG00000001966	ARL1	100	99.448	Callithrix_jacchus
ENSG00000120805	ARL1	100	99.448	ENSCAFG00000006992	ARL1	100	99.448	Canis_familiaris
ENSG00000120805	ARL1	100	99.448	ENSCAFG00020024333	ARL1	100	99.448	Canis_lupus_dingo
ENSG00000120805	ARL1	100	99.390	ENSCHIG00000024524	ARL1	100	99.412	Capra_hircus
ENSG00000120805	ARL1	100	99.390	ENSTSYG00000013257	-	100	99.441	Carlito_syrichta
ENSG00000120805	ARL1	84	97.826	ENSCAPG00000001010	ARL1	100	97.826	Cavia_aperea
ENSG00000120805	ARL1	100	98.343	ENSCPOG00000026014	ARL1	100	98.343	Cavia_porcellus
ENSG00000120805	ARL1	100	99.448	ENSCCAG00000025938	ARL1	100	99.448	Cebus_capucinus
ENSG00000120805	ARL1	100	97.561	ENSCLAG00000008180	ARL1	100	97.238	Chinchilla_lanigera
ENSG00000120805	ARL1	100	100.000	ENSCSAG00000003368	ARL1	100	100.000	Chlorocebus_sabaeus
ENSG00000120805	ARL1	100	96.341	ENSCPBG00000004906	ARL1	100	96.133	Chrysemys_picta_bellii
ENSG00000120805	ARL1	99	79.012	ENSCING00000019794	-	92	78.182	Ciona_intestinalis
ENSG00000120805	ARL1	95	44.586	ENSCING00000004577	-	95	43.976	Ciona_intestinalis
ENSG00000120805	ARL1	99	78.395	ENSCSAVG00000007620	-	90	77.576	Ciona_savignyi
ENSG00000120805	ARL1	100	99.448	ENSCANG00000033548	ARL1	100	99.448	Colobus_angolensis_palliatus
ENSG00000120805	ARL1	100	98.895	ENSCGRG00001010446	Arl1	100	98.895	Cricetulus_griseus_chok1gshd
ENSG00000120805	ARL1	100	98.171	ENSCGRG00000009856	Arl1	90	97.790	Cricetulus_griseus_crigri
ENSG00000120805	ARL1	100	93.902	ENSCVAG00000001731	arl1	92	93.413	Cyprinodon_variegatus
ENSG00000120805	ARL1	100	95.122	ENSDARG00000101680	arl1	92	95.570	Danio_rerio
ENSG00000120805	ARL1	100	99.390	ENSDORG00000014770	Arl1	95	98.895	Dipodomys_ordii
ENSG00000120805	ARL1	100	81.098	FBgn0000115	Arl1	93	80.838	Drosophila_melanogaster
ENSG00000120805	ARL1	100	96.364	ENSETEG00000020310	ARL1	100	96.629	Echinops_telfairi
ENSG00000120805	ARL1	100	99.448	ENSEASG00005020057	ARL1	100	99.448	Equus_asinus_asinus
ENSG00000120805	ARL1	100	99.448	ENSECAG00000000372	ARL1	100	99.448	Equus_caballus
ENSG00000120805	ARL1	100	95.732	ENSELUG00000018440	arl1	92	95.808	Esox_lucius
ENSG00000120805	ARL1	100	93.902	ENSELUG00000001287	-	92	94.012	Esox_lucius
ENSG00000120805	ARL1	100	99.448	ENSFCAG00000030871	ARL1	100	99.448	Felis_catus
ENSG00000120805	ARL1	100	96.341	ENSFALG00000011156	ARL1	100	96.133	Ficedula_albicollis
ENSG00000120805	ARL1	100	98.171	ENSFDAG00000016393	ARL1	100	97.790	Fukomys_damarensis
ENSG00000120805	ARL1	100	93.902	ENSFHEG00000004171	arl1	88	94.012	Fundulus_heteroclitus
ENSG00000120805	ARL1	100	93.902	ENSGMOG00000006859	arl1	92	94.012	Gadus_morhua
ENSG00000120805	ARL1	100	96.341	ENSGALG00000011651	ARL1	100	96.133	Gallus_gallus
ENSG00000120805	ARL1	95	94.839	ENSGAFG00000006973	arl1	95	94.937	Gambusia_affinis
ENSG00000120805	ARL1	100	94.512	ENSGACG00000019098	arl1	92	94.611	Gasterosteus_aculeatus
ENSG00000120805	ARL1	100	100.000	ENSGGOG00000010788	ARL1	100	100.000	Gorilla_gorilla
ENSG00000120805	ARL1	100	93.902	ENSHBUG00000010636	arl1	92	94.012	Haplochromis_burtoni
ENSG00000120805	ARL1	100	98.895	ENSHGLG00000004909	ARL1	100	98.895	Heterocephalus_glaber_female
ENSG00000120805	ARL1	100	98.780	ENSHGLG00100001832	ARL1	100	98.343	Heterocephalus_glaber_male
ENSG00000120805	ARL1	100	94.512	ENSHCOG00000005566	arl1	92	94.611	Hippocampus_comes
ENSG00000120805	ARL1	100	95.122	ENSIPUG00000013834	arl1	90	95.210	Ictalurus_punctatus
ENSG00000120805	ARL1	100	99.448	ENSSTOG00000016022	ARL1	100	99.448	Ictidomys_tridecemlineatus
ENSG00000120805	ARL1	100	89.024	ENSJJAG00000000452	-	92	89.222	Jaculus_jaculus
ENSG00000120805	ARL1	95	95.484	ENSKMAG00000005931	arl1	84	95.484	Kryptolebias_marmoratus
ENSG00000120805	ARL1	100	92.683	ENSLBEG00000000991	arl1	95	92.814	Labrus_bergylta
ENSG00000120805	ARL1	100	99.448	ENSLAFG00000026143	ARL1	95	99.448	Loxodonta_africana
ENSG00000120805	ARL1	100	100.000	ENSMFAG00000035725	ARL1	100	100.000	Macaca_fascicularis
ENSG00000120805	ARL1	100	100.000	ENSMMUG00000031610	ARL1	100	99.448	Macaca_mulatta
ENSG00000120805	ARL1	100	100.000	ENSMNEG00000007067	ARL1	100	100.000	Macaca_nemestrina
ENSG00000120805	ARL1	100	100.000	ENSMLEG00000036143	ARL1	100	100.000	Mandrillus_leucophaeus
ENSG00000120805	ARL1	100	92.683	ENSMAMG00000001968	arl1	93	92.814	Mastacembelus_armatus
ENSG00000120805	ARL1	100	93.902	ENSMZEG00005018136	arl1	92	94.012	Maylandia_zebra
ENSG00000120805	ARL1	100	96.341	ENSMGAG00000011748	ARL1	92	96.407	Meleagris_gallopavo
ENSG00000120805	ARL1	100	98.343	ENSMAUG00000021923	Arl1	100	98.343	Mesocricetus_auratus
ENSG00000120805	ARL1	100	99.448	ENSMICG00000015801	ARL1	100	99.448	Microcebus_murinus
ENSG00000120805	ARL1	100	98.895	ENSMOCG00000005852	Arl1	100	98.895	Microtus_ochrogaster
ENSG00000120805	ARL1	96	92.357	ENSMMOG00000003353	arl1	63	92.500	Mola_mola
ENSG00000120805	ARL1	100	98.171	ENSMODG00000003056	ARL1	100	97.790	Monodelphis_domestica
ENSG00000120805	ARL1	100	93.293	ENSMALG00000003003	arl1	99	93.333	Monopterus_albus
ENSG00000120805	ARL1	100	98.895	MGP_CAROLIEiJ_G0015712	Arl1	100	98.895	Mus_caroli
ENSG00000120805	ARL1	100	98.895	ENSMUSG00000060904	Arl1	100	98.895	Mus_musculus
ENSG00000120805	ARL1	100	98.895	MGP_PahariEiJ_G0031373	Arl1	100	98.895	Mus_pahari
ENSG00000120805	ARL1	100	98.895	MGP_SPRETEiJ_G0016530	Arl1	100	98.895	Mus_spretus
ENSG00000120805	ARL1	100	98.788	ENSMPUG00000011822	ARL1	99	98.895	Mustela_putorius_furo
ENSG00000120805	ARL1	95	99.355	ENSMLUG00000002351	-	100	98.837	Myotis_lucifugus
ENSG00000120805	ARL1	100	93.902	ENSMLUG00000025321	-	92	93.413	Myotis_lucifugus
ENSG00000120805	ARL1	84	98.551	ENSNGAG00000007879	-	100	98.551	Nannospalax_galili
ENSG00000120805	ARL1	100	93.902	ENSNBRG00000019783	arl1	92	94.012	Neolamprologus_brichardi
ENSG00000120805	ARL1	100	100.000	ENSNLEG00000006223	ARL1	100	100.000	Nomascus_leucogenys
ENSG00000120805	ARL1	100	98.171	ENSMEUG00000015525	ARL1	95	97.790	Notamacropus_eugenii
ENSG00000120805	ARL1	100	98.895	ENSODEG00000019783	-	100	98.895	Octodon_degus
ENSG00000120805	ARL1	100	98.780	ENSODEG00000010531	-	100	98.889	Octodon_degus
ENSG00000120805	ARL1	100	97.238	ENSODEG00000019880	-	100	97.238	Octodon_degus
ENSG00000120805	ARL1	100	93.902	ENSONIG00000009921	arl1	92	94.012	Oreochromis_niloticus
ENSG00000120805	ARL1	100	99.448	ENSOCUG00000002217	ARL1	96	99.448	Oryctolagus_cuniculus
ENSG00000120805	ARL1	95	94.839	ENSORLG00000008909	arl1	93	94.937	Oryzias_latipes
ENSG00000120805	ARL1	100	93.902	ENSORLG00020005754	arl1	93	94.012	Oryzias_latipes_hni
ENSG00000120805	ARL1	100	93.902	ENSORLG00015002736	arl1	93	94.937	Oryzias_latipes_hsok
ENSG00000120805	ARL1	100	93.902	ENSOMEG00000023497	arl1	89	94.012	Oryzias_melastigma
ENSG00000120805	ARL1	100	98.895	ENSOGAG00000015144	ARL1	100	98.895	Otolemur_garnettii
ENSG00000120805	ARL1	100	99.448	ENSOARG00000015007	ARL1	100	99.448	Ovis_aries
ENSG00000120805	ARL1	100	100.000	ENSPPAG00000034860	ARL1	100	100.000	Pan_paniscus
ENSG00000120805	ARL1	100	99.448	ENSPPRG00000023908	ARL1	100	99.448	Panthera_pardus
ENSG00000120805	ARL1	100	99.390	ENSPTIG00000002154	-	100	99.441	Panthera_tigris_altaica
ENSG00000120805	ARL1	100	100.000	ENSPTRG00000005350	ARL1	100	100.000	Pan_troglodytes
ENSG00000120805	ARL1	100	100.000	ENSPANG00000018816	ARL1	100	98.454	Papio_anubis
ENSG00000120805	ARL1	100	95.732	ENSPKIG00000007118	arl1	100	95.732	Paramormyrops_kingsleyae
ENSG00000120805	ARL1	100	97.561	ENSPSIG00000006539	ARL1	100	96.685	Pelodiscus_sinensis
ENSG00000120805	ARL1	95	92.903	ENSPMGG00000004070	arl1	93	93.038	Periophthalmus_magnuspinnatus
ENSG00000120805	ARL1	100	98.895	ENSPEMG00000008781	Arl1	100	98.895	Peromyscus_maniculatus_bairdii
ENSG00000120805	ARL1	100	93.902	ENSPMAG00000002070	arl1	92	93.413	Petromyzon_marinus
ENSG00000120805	ARL1	100	98.171	ENSPCIG00000009683	-	97	97.778	Phascolarctos_cinereus
ENSG00000120805	ARL1	100	93.902	ENSPFOG00000003241	arl1	92	94.012	Poecilia_formosa
ENSG00000120805	ARL1	100	93.902	ENSPLAG00000012898	arl1	92	94.012	Poecilia_latipinna
ENSG00000120805	ARL1	100	93.902	ENSPMEG00000005938	arl1	89	94.012	Poecilia_mexicana
ENSG00000120805	ARL1	100	93.902	ENSPREG00000013361	arl1	89	94.012	Poecilia_reticulata
ENSG00000120805	ARL1	100	100.000	ENSPPYG00000004872	ARL1	100	100.000	Pongo_abelii
ENSG00000120805	ARL1	100	97.561	ENSPCOG00000015554	-	100	95.580	Propithecus_coquereli
ENSG00000120805	ARL1	100	99.448	ENSPVAG00000008119	ARL1	95	99.448	Pteropus_vampyrus
ENSG00000120805	ARL1	100	93.902	ENSPNYG00000011671	arl1	92	94.012	Pundamilia_nyererei
ENSG00000120805	ARL1	95	96.129	ENSPNAG00000028795	arl1	95	96.203	Pygocentrus_nattereri
ENSG00000120805	ARL1	100	98.895	ENSRNOG00000005763	Arl1	100	98.895	Rattus_norvegicus
ENSG00000120805	ARL1	100	100.000	ENSRBIG00000042560	ARL1	100	100.000	Rhinopithecus_bieti
ENSG00000120805	ARL1	100	100.000	ENSRROG00000037996	ARL1	100	100.000	Rhinopithecus_roxellana
ENSG00000120805	ARL1	100	99.448	ENSSBOG00000024352	-	100	99.448	Saimiri_boliviensis_boliviensis
ENSG00000120805	ARL1	100	98.171	ENSSHAG00000004634	ARL1	100	97.238	Sarcophilus_harrisii
ENSG00000120805	ARL1	100	95.732	ENSSFOG00015001665	arl1	92	95.210	Scleropages_formosus
ENSG00000120805	ARL1	100	93.923	ENSSMAG00000016416	arl1	92	94.012	Scophthalmus_maximus
ENSG00000120805	ARL1	95	95.484	ENSSDUG00000013898	arl1	89	95.570	Seriola_dumerili
ENSG00000120805	ARL1	100	94.512	ENSSLDG00000012946	arl1	92	94.611	Seriola_lalandi_dorsalis
ENSG00000120805	ARL1	100	98.171	ENSSARG00000013944	ARL1	100	98.324	Sorex_araneus
ENSG00000120805	ARL1	100	97.561	ENSSPUG00000004578	ARL1	100	97.238	Sphenodon_punctatus
ENSG00000120805	ARL1	100	93.902	ENSSPAG00000014633	arl1	93	94.012	Stegastes_partitus
ENSG00000120805	ARL1	100	99.448	ENSSSCG00000000870	ARL1	100	99.448	Sus_scrofa
ENSG00000120805	ARL1	100	96.341	ENSTGUG00000009085	-	100	96.089	Taeniopygia_guttata
ENSG00000120805	ARL1	100	91.463	ENSTRUG00000006254	arl1	92	91.617	Takifugu_rubripes
ENSG00000120805	ARL1	100	91.463	ENSTNIG00000006920	arl1	92	91.617	Tetraodon_nigroviridis
ENSG00000120805	ARL1	100	97.802	ENSTBEG00000015546	ARL1	100	97.802	Tupaia_belangeri
ENSG00000120805	ARL1	100	99.448	ENSTTRG00000017202	ARL1	95	99.448	Tursiops_truncatus
ENSG00000120805	ARL1	100	99.448	ENSUMAG00000019547	ARL1	100	99.448	Ursus_maritimus
ENSG00000120805	ARL1	100	99.448	ENSVPAG00000011621	ARL1	95	99.448	Vicugna_pacos
ENSG00000120805	ARL1	100	99.448	ENSVVUG00000018044	ARL1	100	99.448	Vulpes_vulpes
ENSG00000120805	ARL1	100	96.685	ENSXETG00000002540	arl1	100	96.685	Xenopus_tropicalis
ENSG00000120805	ARL1	100	92.073	ENSXMAG00000028338	arl1	91	94.488	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003924	GTPase activity	8798635.9624189.	IDA	Function
GO:0005525	GTP binding	21873635.	IBA	Function
GO:0005525	GTP binding	9624189.	IDA	Function
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	-	ISS	Component
GO:0005794	Golgi apparatus	21873635.	IBA	Component
GO:0005794	Golgi apparatus	19224922.	IDA	Component
GO:0005802	trans-Golgi network	17488291.	IDA	Component
GO:0005802	trans-Golgi network	-	ISS	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006886	intracellular protein transport	21873635.	IBA	Process
GO:0007030	Golgi organization	-	ISS	Process
GO:0008047	enzyme activator activity	9624189.	IDA	Function
GO:0009404	toxin metabolic process	9624189.	IDA	Process
GO:0016192	vesicle-mediated transport	21873635.	IBA	Process
GO:0019904	protein domain specific binding	14580338.	IPI	Function
GO:0031584	activation of phospholipase D activity	9624189.	IDA	Process
GO:0032588	trans-Golgi network membrane	-	TAS	Component
GO:0034067	protein localization to Golgi apparatus	19224922.	IMP	Process
GO:0042147	retrograde transport, endosome to Golgi	19224922.	IMP	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0048193	Golgi vesicle transport	-	IEA	Process