EuRBPDB

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  • Description
  • RBDs
  • RBPome
  • PRI
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Phenotypes
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000121057 (Gene tree)
Gene ID
8165
Gene Symbol
AKAP1
Alias
AKAP121|AKAP149|SAKAP84|S-AKAP84|AKAP84|D-AKAP1|PPP1R43|TDRD17|PRKA1
Full Name
A-kinase anchoring protein 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
36,258 bases
Position
chr17:57,085,092-57,121,349
Accession
367
RBP type
canonical RBP
Summary
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to type I and type II regulatory subunits of PKA and anchors them to the mitochondrion. This protein is speculated to be involved in the cAMP-dependent signal transduction pathway and in directing RNA to a specific cellular compartment. [provided by RefSeq, Jul 2008]
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000337736KH_1PF00013.291.4e-1011
ENSP00000443139KH_1PF00013.291.4e-1011
ENSP00000459895KH_1PF00013.291.4e-1011
ENSP00000459968KH_1PF00013.291.4e-1011
ENSP00000478212KH_1PF00013.291.4e-1011
ENSP00000337736TUDORPF00567.241.9e-2111
ENSP00000443139TUDORPF00567.241.9e-2111
ENSP00000459895TUDORPF00567.241.9e-2111
ENSP00000459968TUDORPF00567.241.9e-2111
ENSP00000478212TUDORPF00567.241.9e-2111
ENSP00000460762TUDORPF00567.245.4e-2111
ENSP00000458370TUDORPF00567.241.2e-1211
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNARIC & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30352994Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome captureRIC & Jurkat2018 Oct 23Perez-Perri JIDOI:10.1038/s41467-018-06557-8
Protein-RNA interaction(RNA-Binding Site)
Click here to download all RNA binding sites
Click here to download all RNA binding sites

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
12218046The translational regulation of lipoprotein lipase by epinephrine involves an RNA binding complex including the catalytic subunit of protein kinase A.J Biol Chem2002 Nov 8Ranganathan G-
18387001Translational regulation of lipoprotein lipase in adipocytes: depletion of cellular protein kinase Calpha activates binding of the C subunit of protein kinase A to the 3'-untranslated region of the lipoprotein lipase mRNA.Biochem J2008 Jul 15Unal Rdoi: 10.1042/BJ20071559.
19074462Mutually exclusive binding of PP1 and RNA to AKAP149 affects the mitochondrial network.Hum Mol Genet2009 Mar 1Rogne Mdoi: 10.1093/hmg/ddn425
10415327Characterization of three genes, AKAP84, BAW and WSB1, located 3' to the neurofibromatosis type 1 locus in Fugu rubripes.Gene1999 Jul 22Kehrer-Sawatzki H-
18497968Specific proteolysis of the A-kinase-anchoring protein 149 at the Asp582 residue by caspases during apoptosis.Oncol Rep2008 JunYoo H-
8769136Molecular characterization of AKAP149, a novel A kinase anchor protein with a KH domain.Biochem Biophys Res Commun1996 Aug 5Trendelenburg G-
12654270PKA-dependent binding of mRNA to the mitochondrial AKAP121 protein.J Mol Biol2003 Apr 4Ginsberg MD-
15961507Role of A kinase anchor proteins in the tissue-specific regulation of lipoprotein lipase.Mol Endocrinol2005 OctRanganathan G-
17154535The KH-Tudor domain of a-kinase anchoring protein 149 mediates RNA-dependent self-association.Biochemistry2006 Dec 19Rogne M-
22244040The lipoprotein lipase (LPL) S447X gain of function variant involves increased mRNA translation.Atherosclerosis2012 MarRanganathan Gdoi: 10.1016/j.atherosclerosis.2011.12.028
23077346Short RNA molecules with high binding affinity to the KH motif of A-kinase anchoring protein 1 (AKAP1): implications for the regulation of steroidogenesis.Mol Endocrinol2012 DecGrozdanov PNdoi: 10.1210/me.2012-1123
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000621116AKAP1-2194285XM_005257709ENSP00000478212903 (aa)XP_005257766Q92667
ENST00000572557AKAP1-2083098XM_017025190ENSP00000459895903 (aa)XP_016880679Q92667
ENST00000575322AKAP1-216650-ENSP00000459808186 (aa)-I3L2N7
ENST00000573326AKAP1-2121580-ENSP00000461854360 (aa)-I3NI36
ENST00000574683AKAP1-213588-ENSP0000046020995 (aa)-I3L364
ENST00000575186AKAP1-215578-ENSP000004614187 (aa)-A0A0G2JLF7
ENST00000576295AKAP1-217614-ENSP00000458378204 (aa)-I3L0W0
ENST00000572814AKAP1-210532-ENSP00000458164137 (aa)-I3L0K6
ENST00000337714AKAP1-2023970-ENSP00000337736903 (aa)-Q92667
ENST00000314126AKAP1-2012380-ENSP00000314075593 (aa)-Q92667
ENST00000575032AKAP1-214570-ENSP00000460762179 (aa)-I3L3V6
ENST00000571629AKAP1-2063105XM_005257707ENSP00000459968903 (aa)XP_005257764Q92667
ENST00000576591AKAP1-218565-ENSP0000046051483 (aa)-I3L3K1
ENST00000573085AKAP1-211484-ENSP0000046055747 (aa)-I3L3L9
ENST00000539273AKAP1-2043153XM_024450960ENSP00000443139903 (aa)XP_024306728Q92667
ENST00000570423AKAP1-205568-ENSP000004589827 (aa)-A0A0G2JLF7
ENST00000481416AKAP1-2034089-ENSP00000433212593 (aa)-Q92667
ENST00000572560AKAP1-209442-ENSP00000458370139 (aa)-I3L0V5
ENST00000572156AKAP1-207710-ENSP00000459521182 (aa)-I3L2A2
Gene Model
Click here to download ENSG00000121057's gene model file
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000121057Creatinine7.428e-005-
ENSG00000121057Creatinine7.428e-005-
ENSG00000121057Platelet Function Tests1.8677500E-005-
ENSG00000121057Platelet Function Tests2.4268448E-006-
ENSG00000121057Alopecia2E-1227182965
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000121057's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000121057AKAP19472.781ENSAPOG00000015611akap1b5460.550Acanthochromis_polyacanthus
ENSG00000121057AKAP19497.041ENSAMEG00000002704AKAP19971.617Ailuropoda_melanoleuca
ENSG00000121057AKAP19471.006ENSACIG00000011298akap1b5561.860Amphilophus_citrinellus
ENSG00000121057AKAP19472.781ENSAOCG00000014786akap1b6060.092Amphiprion_ocellaris
ENSG00000121057AKAP19472.781ENSAPEG00000007202akap1b6270.997Amphiprion_percula
ENSG00000121057AKAP19471.598ENSATEG00000004754akap1b5460.544Anabas_testudineus
ENSG00000121057AKAP19479.290ENSAPLG00000014520AKAP110047.747Anas_platyrhynchos
ENSG00000121057AKAP16882.645ENSACAG00000008920AKAP19673.927Anolis_carolinensis
ENSG00000121057AKAP110095.745ENSANAG00000032242AKAP110095.833Aotus_nancymaae
ENSG00000121057AKAP19472.189ENSAMXG00000024876akap1b7750.512Astyanax_mexicanus
ENSG00000121057AKAP18356.757ENSAMXG00000033797akap1a5247.135Astyanax_mexicanus
ENSG00000121057AKAP19497.619ENSBTAG00000025320AKAP110068.357Bos_taurus
ENSG00000121057AKAP19838.122WBGene00016977akap-17534.628Caenorhabditis_elegans
ENSG00000121057AKAP110095.745ENSCJAG00000013990AKAP19997.213Callithrix_jacchus
ENSG00000121057AKAP19497.619ENSCAFG00000017409AKAP110072.907Canis_familiaris
ENSG00000121057AKAP19497.619ENSCAFG00020025614AKAP110071.598Canis_lupus_dingo
ENSG00000121057AKAP19497.619ENSCHIG00000024545AKAP110067.802Capra_hircus
ENSG00000121057AKAP19192.063ENSTSYG00000031206-10091.304Carlito_syrichta
ENSG00000121057AKAP110080.000ENSCAPG00000016471AKAP19965.457Cavia_aperea
ENSG00000121057AKAP19497.619ENSCPOG00000013327AKAP110069.155Cavia_porcellus
ENSG00000121057AKAP110093.617ENSCCAG00000023539AKAP19996.516Cebus_capucinus
ENSG00000121057AKAP110097.872ENSCATG00000043975AKAP19998.955Cercocebus_atys
ENSG00000121057AKAP19499.405ENSCLAG00000015261AKAP110070.472Chinchilla_lanigera
ENSG00000121057AKAP110097.872ENSCSAG00000005628AKAP110092.137Chlorocebus_sabaeus
ENSG00000121057AKAP19480.473ENSCPBG00000010075AKAP110050.645Chrysemys_picta_bellii
ENSG00000121057AKAP18837.705ENSCING00000013623-8837.879Ciona_intestinalis
ENSG00000121057AKAP110097.872ENSCANG00000011430-9998.955Colobus_angolensis_palliatus
ENSG00000121057AKAP19495.833ENSCANG00000042158-9990.244Colobus_angolensis_palliatus
ENSG00000121057AKAP19498.214ENSCGRG00001005318Akap110066.482Cricetulus_griseus_chok1gshd
ENSG00000121057AKAP19498.214ENSCGRG00000006349Akap19665.487Cricetulus_griseus_crigri
ENSG00000121057AKAP19472.189ENSCSEG00000004730akap1b5158.565Cynoglossus_semilaevis
ENSG00000121057AKAP18867.742ENSCVAG00000007856akap1b5752.778Cyprinodon_variegatus
ENSG00000121057AKAP19497.619ENSDNOG00000035461AKAP19971.601Dasypus_novemcinctus
ENSG00000121057AKAP19498.810ENSDORG00000030157Akap110067.838Dipodomys_ordii
ENSG00000121057AKAP19335.329FBgn0263987spoon5930.460Drosophila_melanogaster
ENSG00000121057AKAP110078.723ENSETEG00000009121AKAP110053.304Echinops_telfairi
ENSG00000121057AKAP19497.619ENSEASG00005002989AKAP110075.881Equus_asinus_asinus
ENSG00000121057AKAP19497.619ENSECAG00000009841AKAP110075.881Equus_caballus
ENSG00000121057AKAP19062.733ENSELUG00000011820-6761.462Esox_lucius
ENSG00000121057AKAP19497.024ENSFCAG00000006839AKAP19071.663Felis_catus
ENSG00000121057AKAP19473.373ENSFALG00000004977AKAP18451.024Ficedula_albicollis
ENSG00000121057AKAP19498.810ENSFDAG00000014839AKAP19870.143Fukomys_damarensis
ENSG00000121057AKAP19472.781ENSGMOG00000015334akap1b5151.532Gadus_morhua
ENSG00000121057AKAP19478.107ENSGALG00000005575AKAP110048.000Gallus_gallus
ENSG00000121057AKAP19472.189ENSGAFG00000010957akap1b5060.563Gambusia_affinis
ENSG00000121057AKAP17956.757ENSGACG00000013633akap1b6845.270Gasterosteus_aculeatus
ENSG00000121057AKAP19480.473ENSGAGG00000016534AKAP110050.652Gopherus_agassizii
ENSG00000121057AKAP1100100.000ENSGGOG00000011719AKAP110099.306Gorilla_gorilla
ENSG00000121057AKAP19498.214ENSHGLG00000014384AKAP110067.579Heterocephalus_glaber_female
ENSG00000121057AKAP19498.214ENSHGLG00100002765AKAP110065.758Heterocephalus_glaber_male
ENSG00000121057AKAP19472.781ENSHCOG00000012771akap1b7057.895Hippocampus_comes
ENSG00000121057AKAP19472.189ENSIPUG00000003688akap1b6160.317Ictalurus_punctatus
ENSG00000121057AKAP19772.727ENSSTOG00000022206AKAP19664.311Ictidomys_tridecemlineatus
ENSG00000121057AKAP19497.024ENSJJAG00000010284Akap19770.374Jaculus_jaculus
ENSG00000121057AKAP19472.189ENSLBEG00000016545akap1b6159.641Labrus_bergylta
ENSG00000121057AKAP19477.515ENSLOCG00000004703akap1b6363.573Lepisosteus_oculatus
ENSG00000121057AKAP19497.619ENSLAFG00000015929AKAP110073.238Loxodonta_africana
ENSG00000121057AKAP110097.872ENSMFAG00000042936AKAP19998.955Macaca_fascicularis
ENSG00000121057AKAP1100100.000ENSMMUG00000012644AKAP1100100.000Macaca_mulatta
ENSG00000121057AKAP110097.872ENSMNEG00000001016AKAP19998.955Macaca_nemestrina
ENSG00000121057AKAP110097.872ENSMLEG00000036269AKAP19998.955Mandrillus_leucophaeus
ENSG00000121057AKAP19472.189ENSMAMG00000003966akap1b5560.682Mastacembelus_armatus
ENSG00000121057AKAP19795.376ENSMAUG00000011059Akap19964.027Mesocricetus_auratus
ENSG00000121057AKAP19497.619ENSMICG00000013586AKAP110078.855Microcebus_murinus
ENSG00000121057AKAP19496.429ENSMOCG00000010636Akap110066.667Microtus_ochrogaster
ENSG00000121057AKAP19472.189ENSMMOG00000010029akap1b6557.883Mola_mola
ENSG00000121057AKAP19485.119ENSMODG00000028428-10085.583Monodelphis_domestica
ENSG00000121057AKAP19475.148ENSMALG00000000761akap1b5561.731Monopterus_albus
ENSG00000121057AKAP19498.214MGP_CAROLIEiJ_G0016949Akap110067.108Mus_caroli
ENSG00000121057AKAP19498.214ENSMUSG00000018428Akap110067.255Mus_musculus
ENSG00000121057AKAP19497.619MGP_PahariEiJ_G0018080Akap110066.998Mus_pahari
ENSG00000121057AKAP19498.214MGP_SPRETEiJ_G0017796Akap110067.660Mus_spretus
ENSG00000121057AKAP19496.429ENSMPUG00000015380AKAP110070.582Mustela_putorius_furo
ENSG00000121057AKAP19497.024ENSMLUG00000010820AKAP19972.418Myotis_lucifugus
ENSG00000121057AKAP19497.024ENSNGAG00000014799-8496.181Nannospalax_galili
ENSG00000121057AKAP110095.745ENSNLEG00000031371AKAP110099.306Nomascus_leucogenys
ENSG00000121057AKAP19773.333ENSMEUG00000003844AKAP110054.495Notamacropus_eugenii
ENSG00000121057AKAP19497.024ENSOPRG00000016488-10072.527Ochotona_princeps
ENSG00000121057AKAP19472.781ENSONIG00000014829akap1b6458.405Oreochromis_niloticus
ENSG00000121057AKAP19482.249ENSOANG00000005674AKAP110052.568Ornithorhynchus_anatinus
ENSG00000121057AKAP19498.214ENSOCUG00000017563AKAP110075.275Oryctolagus_cuniculus
ENSG00000121057AKAP16663.445ENSORLG00000015123-9763.866Oryzias_latipes
ENSG00000121057AKAP19471.598ENSORLG00020007559akap1b7250.714Oryzias_latipes_hni
ENSG00000121057AKAP17955.401ENSORLG00015013428-8757.343Oryzias_latipes_hsok
ENSG00000121057AKAP19471.006ENSOMEG00000013912akap1b7250.000Oryzias_melastigma
ENSG00000121057AKAP110093.333ENSOGAG00000011014AKAP19977.936Otolemur_garnettii
ENSG00000121057AKAP19497.619ENSOARG00000007626AKAP19681.315Ovis_aries
ENSG00000121057AKAP1100100.000ENSPPAG00000031095AKAP110099.306Pan_paniscus
ENSG00000121057AKAP19497.024ENSPTIG00000016355AKAP18388.320Panthera_tigris_altaica
ENSG00000121057AKAP1100100.000ENSPTRG00000009436AKAP110099.306Pan_troglodytes
ENSG00000121057AKAP110097.872ENSPANG00000022318AKAP19998.955Papio_anubis
ENSG00000121057AKAP19472.781ENSPKIG00000017133akap1b6162.326Paramormyrops_kingsleyae
ENSG00000121057AKAP19257.317ENSPKIG00000007175-5454.362Paramormyrops_kingsleyae
ENSG00000121057AKAP19479.882ENSPSIG00000007675AKAP110050.272Pelodiscus_sinensis
ENSG00000121057AKAP19471.598ENSPMGG00000011644akap1b5571.091Periophthalmus_magnuspinnatus
ENSG00000121057AKAP19496.429ENSPEMG00000023415Akap110067.327Peromyscus_maniculatus_bairdii
ENSG00000121057AKAP19484.524ENSPCIG00000006037AKAP110058.433Phascolarctos_cinereus
ENSG00000121057AKAP19472.189ENSPFOG00000005623akap1b5360.000Poecilia_formosa
ENSG00000121057AKAP19472.189ENSPLAG00000005425akap1b5160.092Poecilia_latipinna
ENSG00000121057AKAP19472.189ENSPMEG00000016287akap1b5160.092Poecilia_mexicana
ENSG00000121057AKAP19472.189ENSPREG00000014531akap1b5159.310Poecilia_reticulata
ENSG00000121057AKAP110095.789ENSPPYG00000008245AKAP110095.460Pongo_abelii
ENSG00000121057AKAP19295.122ENSPCAG00000013847AKAP110065.749Procavia_capensis
ENSG00000121057AKAP19498.214ENSPCOG00000012982AKAP110077.533Propithecus_coquereli
ENSG00000121057AKAP19496.429ENSPVAG00000002188AKAP110072.437Pteropus_vampyrus
ENSG00000121057AKAP19356.548ENSPNAG00000014984akap1a5446.318Pygocentrus_nattereri
ENSG00000121057AKAP19471.598ENSPNAG00000000820akap1b7850.084Pygocentrus_nattereri
ENSG00000121057AKAP19498.214ENSRNOG00000002373Akap110067.657Rattus_norvegicus
ENSG00000121057AKAP110095.745ENSRBIG00000033113AKAP19998.955Rhinopithecus_bieti
ENSG00000121057AKAP110095.745ENSRROG00000010936AKAP19998.955Rhinopithecus_roxellana
ENSG00000121057AKAP110095.745ENSSBOG00000019056AKAP19997.213Saimiri_boliviensis_boliviensis
ENSG00000121057AKAP19484.615ENSSHAG00000013278AKAP110057.918Sarcophilus_harrisii
ENSG00000121057AKAP19474.556ENSSFOG00015012205akap18848.641Scleropages_formosus
ENSG00000121057AKAP19473.373ENSSDUG00000019393akap1b6160.179Seriola_dumerili
ENSG00000121057AKAP19473.373ENSSLDG00000001859akap1b6160.179Seriola_lalandi_dorsalis
ENSG00000121057AKAP19481.548ENSSARG00000011998-10059.787Sorex_araneus
ENSG00000121057AKAP16354.741ENSSPUG00000000931-9875.591Sphenodon_punctatus
ENSG00000121057AKAP19472.189ENSSPAG00000005133akap1b5270.085Stegastes_partitus
ENSG00000121057AKAP19498.214ENSSSCG00000034994AKAP110071.665Sus_scrofa
ENSG00000121057AKAP19472.189ENSTGUG00000008464-9162.624Taeniopygia_guttata
ENSG00000121057AKAP15655.224ENSTGUG00000014201-10055.224Taeniopygia_guttata
ENSG00000121057AKAP19473.373ENSTRUG00000005669akap15560.798Takifugu_rubripes
ENSG00000121057AKAP19474.556ENSTNIG00000004987akap1b9971.495Tetraodon_nigroviridis
ENSG00000121057AKAP110093.333ENSTBEG00000009492AKAP18870.735Tupaia_belangeri
ENSG00000121057AKAP110085.333ENSTTRG00000002188AKAP110068.910Tursiops_truncatus
ENSG00000121057AKAP19993.785ENSUAMG00000007244AKAP19871.186Ursus_americanus
ENSG00000121057AKAP19196.032ENSUMAG00000000509-10096.273Ursus_maritimus
ENSG00000121057AKAP19373.214ENSVPAG00000008289-10060.411Vicugna_pacos
ENSG00000121057AKAP19497.619ENSVVUG00000011740AKAP110090.411Vulpes_vulpes
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0003723RNA binding22658674.22681889.HDAFunction
GO:0005515protein binding16642035.24083380.26496610.IPIFunction
GO:0005739mitochondrion-IDAComponent
GO:0005741mitochondrial outer membrane-IEAComponent
GO:0005829cytosol-TASComponent
GO:0007596blood coagulation-TASProcess
GO:0010738regulation of protein kinase A signaling-IEAProcess
GO:0016020membrane19946888.HDAComponent
GO:0016021integral component of membrane-IEAComponent
GO:0034237protein kinase A regulatory subunit binding17911601.IPIFunction

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