EuRBPDB

Description

Ensembl ID: ENSG00000121058 (Gene tree)
Gene ID: 8161
Gene Symbol: COIL
Alias: CLN80|p80-coilin
Full Name: coilin
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 22,868 bases
Position: chr17:56,938,187-56,961,054
Accession: 2184
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is an integral component of Cajal bodies (also called coiled bodies). Cajal bodies are nuclear suborganelles of varying number and composition that are involved in the post-transcriptional modification of small nuclear and small nucleolar RNAs. The N-terminus of the coilin protein directs its self-oligomerization while the C-terminus influences the number of nuclear bodies assembled per cell. Differential methylation and phosphorylation of coilin likely influences its localization among nuclear bodies and the composition and assembly of Cajal bodies. This gene has pseudogenes on chromosome 4 and chromosome 14. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
12954622	Intracellular localization of differentially regulated RNA-specific adenosine deaminase isoforms in inflammation.	J Biol Chem	2003 Nov 14	Yang JH	-
23320094	Plant coilin: structural characteristics and RNA-binding properties.	PLoS One	2013	Makarov V	doi: 10.1371/journal.pone.0053571
23274112	Coilin displays differential affinity for specific RNAs in vivo and is linked to telomerase RNA biogenesis.	J Mol Biol	2013 Feb 22	Broome HJ	doi: 10.1016/j.jmb.2012.12.014
11319160	Immunolocalization of nucleolar proteins during bovine oocyte growth, meiotic maturation, and fertilization.	Biol Reprod	2001 May	Fair T	-
9112227	The behavior of the coiled body in cells infected with adenovirus in vitro.	Mol Biol Rep	1996	Rodrigues SH	-
12591912	Steady-state dynamics of Cajal body components in the Xenopus germinal vesicle.	J Cell Biol	2003 Feb 17	Handwerger KE	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000573008	COIL-202	466	-	ENSP00000460217	37 (aa)	-	I3L369
ENST00000240316	COIL-201	2650	-	ENSP00000240316	576 (aa)	-	P38432

Gene Model

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001650	fibrillar center	-	IDA	Component
GO:0005515	protein binding	12757932.16079131.16713569.21070772.21072240.21920476.23685356.25416956.27107012.29934401.	IPI	Function
GO:0005634	nucleus	19734146.	IDA	Component
GO:0005654	nucleoplasm	12757932.	IDA	Component
GO:0005730	nucleolus	12757932.	IDA	Component
GO:0008022	protein C-terminus binding	12757932.	IPI	Function
GO:0015030	Cajal body	12757932.16687569.17577209.22547674.	IDA	Component
GO:0016020	membrane	19946888.	HDA	Component
GO:0016604	nuclear body	-	IDA	Component
GO:0042802	identical protein binding	16713569.	IPI	Function