EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000121988 (Gene tree)
Gene ID: 84083
Gene Symbol: ZRANB3
Alias: DKFZP434B1727
Full Name: zinc finger RANBP2-type containing 3
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 394,407 bases
Position: chr2:135,136,916-135,531,322
Accession: 25249
RBP type: canonical RBP
Summary: ZRANB3 (Zinc Finger RANBP2-Type Containing 3) is a Protein Coding gene. Diseases associated with ZRANB3 include Warburg Micro Syndrome 1. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and endonuclease activity. An important paralog of this gene is SMARCAL1.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000480120	zf-RanBP	PF00641.18	6.7e-07	1	1
ENSP00000441320	zf-RanBP	PF00641.18	7e-07	1	1
ENSP00000383979	zf-RanBP	PF00641.18	1.3e-06	1	1
ENSP00000264159	zf-RanBP	PF00641.18	1.3e-06	1	1
ENSP00000383979	ResIII	PF04851.15	7.3e-08	1	1
ENSP00000264159	ResIII	PF04851.15	7.3e-08	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000536680	ZRANB3-210	6943	-	ENSP00000441320	625 (aa)	-	F5GYN7
ENST00000619650	ZRANB3-211	2494	-	ENSP00000480120	598 (aa)	-	Q5FWF4
ENST00000401392	ZRANB3-202	6820	XM_011511963	ENSP00000383979	1077 (aa)	XP_011510265	Q5FWF4
ENST00000264159	ZRANB3-201	4046	XM_005263809	ENSP00000264159	1079 (aa)	XP_005263866	Q5FWF4
ENST00000495945	ZRANB3-209	569	-	-	- (aa)	-	-
ENST00000452187	ZRANB3-205	1269	-	-	- (aa)	-	-
ENST00000472452	ZRANB3-206	823	-	-	- (aa)	-	-
ENST00000403017	ZRANB3-203	4130	-	ENSP00000384245	428 (aa)	-	F8WCT9
ENST00000492193	ZRANB3-208	546	-	-	- (aa)	-	-
ENST00000412849	ZRANB3-204	2572	-	-	- (aa)	-	-
ENST00000474919	ZRANB3-207	611	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000121988's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000121988	Neuroblastoma	1.06E-7	18463370
ENSG00000121988	Depression	8.596e-005	-
ENSG00000121988	Depression	8.368e-005	-
ENSG00000121988	Depression	8.368e-005	-
ENSG00000121988	Depression	9.386e-005	-
ENSG00000121988	Depression	8.368e-005	-
ENSG00000121988	Depression	8.596e-005	-
ENSG00000121988	Depression	4.85e-005	-
ENSG00000121988	Triglycerides	7.5860000E-005	-
ENSG00000121988	Platelet Function Tests	1.3740900E-005	-
ENSG00000121988	Platelet Function Tests	3.0608700E-005	-
ENSG00000121988	Platelet Function Tests	2.2337500E-005	-
ENSG00000121988	Platelet Function Tests	9.8954077E-006	-
ENSG00000121988	Hip	2E-6	25673412
ENSG00000121988	Hip	6E-9	25673412

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000121988	rs1561277	2	135334491	A	Hip circumference	25673412	[0.016-0.032] unit decrease	0.0239	EFO_0005093
ENSG00000121988	rs1561277	2	135334491	A	Hip circumference	25673412	[0.015-0.036] unit decrease	0.0254	EFO_0005093
ENSG00000121988	rs1375131	2	135197227	T	Mosquito bite size	28199695	[0.023-0.046] unit increase	0.0345404	EFO_0008378
ENSG00000121988	rs13384711	2	135418970	T	Mosquito bite size	28199695	[0.024-0.047] unit increase	0.0350246	EFO_0008378

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000121988's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000121988	ZRANB3	91	66.751	ENSAPOG00000020872	zranb3	99	52.672	Acanthochromis_polyacanthus
ENSG00000121988	ZRANB3	95	84.533	ENSAMEG00000016419	ZRANB3	99	84.533	Ailuropoda_melanoleuca
ENSG00000121988	ZRANB3	91	68.861	ENSACIG00000018832	zranb3	99	53.853	Amphilophus_citrinellus
ENSG00000121988	ZRANB3	91	65.743	ENSAOCG00000005122	zranb3	100	50.855	Amphiprion_ocellaris
ENSG00000121988	ZRANB3	91	65.743	ENSAPEG00000016183	zranb3	99	50.434	Amphiprion_percula
ENSG00000121988	ZRANB3	92	69.347	ENSATEG00000000257	zranb3	98	53.205	Anabas_testudineus
ENSG00000121988	ZRANB3	82	81.972	ENSAPLG00000014815	ZRANB3	99	64.359	Anas_platyrhynchos
ENSG00000121988	ZRANB3	89	78.497	ENSACAG00000001934	ZRANB3	98	63.379	Anolis_carolinensis
ENSG00000121988	ZRANB3	99	92.122	ENSANAG00000028768	ZRANB3	96	92.398	Aotus_nancymaae
ENSG00000121988	ZRANB3	91	69.114	ENSACLG00000027313	zranb3	99	54.074	Astatotilapia_calliptera
ENSG00000121988	ZRANB3	94	64.706	ENSAMXG00000003555	zranb3	98	53.520	Astyanax_mexicanus
ENSG00000121988	ZRANB3	94	91.584	ENSBTAG00000026842	ZRANB3	97	92.398	Bos_taurus
ENSG00000121988	ZRANB3	94	93.069	ENSCJAG00000016365	-	99	94.325	Callithrix_jacchus
ENSG00000121988	ZRANB3	100	92.137	ENSCJAG00000011678	-	100	92.137	Callithrix_jacchus
ENSG00000121988	ZRANB3	94	90.099	ENSCAFG00000005054	ZRANB3	99	83.071	Canis_familiaris
ENSG00000121988	ZRANB3	94	90.099	ENSCAFG00020016080	ZRANB3	99	88.046	Canis_lupus_dingo
ENSG00000121988	ZRANB3	94	91.089	ENSCHIG00000025781	ZRANB3	100	84.181	Capra_hircus
ENSG00000121988	ZRANB3	94	87.438	ENSCPOG00000010385	-	98	88.544	Cavia_porcellus
ENSG00000121988	ZRANB3	100	92.969	ENSCCAG00000012014	ZRANB3	100	92.969	Cebus_capucinus
ENSG00000121988	ZRANB3	100	94.880	ENSCATG00000041950	ZRANB3	100	94.314	Cercocebus_atys
ENSG00000121988	ZRANB3	94	87.376	ENSCLAG00000006849	ZRANB3	99	82.358	Chinchilla_lanigera
ENSG00000121988	ZRANB3	100	94.400	ENSCSAG00000016368	ZRANB3	100	96.067	Chlorocebus_sabaeus
ENSG00000121988	ZRANB3	93	78.218	ENSCPBG00000010250	ZRANB3	99	66.111	Chrysemys_picta_bellii
ENSG00000121988	ZRANB3	100	94.080	ENSCANG00000031772	ZRANB3	100	93.645	Colobus_angolensis_palliatus
ENSG00000121988	ZRANB3	100	78.413	ENSCGRG00001000424	Zranb3	99	78.413	Cricetulus_griseus_chok1gshd
ENSG00000121988	ZRANB3	100	78.413	ENSCGRG00000011356	Zranb3	99	78.413	Cricetulus_griseus_crigri
ENSG00000121988	ZRANB3	89	68.831	ENSCSEG00000009111	zranb3	93	52.551	Cynoglossus_semilaevis
ENSG00000121988	ZRANB3	90	71.318	ENSDARG00000091538	zranb3	99	70.342	Danio_rerio
ENSG00000121988	ZRANB3	99	80.127	ENSDNOG00000013613	ZRANB3	99	84.742	Dasypus_novemcinctus
ENSG00000121988	ZRANB3	90	84.156	ENSDORG00000004211	-	98	84.156	Dipodomys_ordii
ENSG00000121988	ZRANB3	100	84.366	ENSEASG00005007414	ZRANB3	100	84.366	Equus_asinus_asinus
ENSG00000121988	ZRANB3	100	84.459	ENSECAG00000011232	ZRANB3	100	84.459	Equus_caballus
ENSG00000121988	ZRANB3	94	85.323	ENSEEUG00000011221	ZRANB3	92	80.597	Erinaceus_europaeus
ENSG00000121988	ZRANB3	89	70.103	ENSELUG00000014333	zranb3	99	51.585	Esox_lucius
ENSG00000121988	ZRANB3	94	90.842	ENSFCAG00000024830	ZRANB3	99	84.366	Felis_catus
ENSG00000121988	ZRANB3	70	76.316	ENSFALG00000013729	-	94	76.316	Ficedula_albicollis
ENSG00000121988	ZRANB3	100	81.331	ENSFDAG00000012573	ZRANB3	100	81.331	Fukomys_damarensis
ENSG00000121988	ZRANB3	92	67.839	ENSFHEG00000018772	zranb3	99	53.565	Fundulus_heteroclitus
ENSG00000121988	ZRANB3	82	67.507	ENSGMOG00000002692	zranb3	91	59.935	Gadus_morhua
ENSG00000121988	ZRANB3	92	75.622	ENSGALG00000012223	ZRANB3	96	74.939	Gallus_gallus
ENSG00000121988	ZRANB3	89	68.312	ENSGAFG00000006177	zranb3	98	52.641	Gambusia_affinis
ENSG00000121988	ZRANB3	89	68.462	ENSGACG00000014926	zranb3	98	54.836	Gasterosteus_aculeatus
ENSG00000121988	ZRANB3	93	77.970	ENSGAGG00000020998	ZRANB3	99	65.152	Gopherus_agassizii
ENSG00000121988	ZRANB3	100	99.073	ENSGGOG00000003782	ZRANB3	100	99.073	Gorilla_gorilla
ENSG00000121988	ZRANB3	91	68.861	ENSHBUG00000015687	zranb3	95	60.215	Haplochromis_burtoni
ENSG00000121988	ZRANB3	94	87.624	ENSHGLG00000015976	ZRANB3	98	81.516	Heterocephalus_glaber_female
ENSG00000121988	ZRANB3	94	87.624	ENSHGLG00100001612	ZRANB3	98	81.516	Heterocephalus_glaber_male
ENSG00000121988	ZRANB3	88	69.452	ENSHCOG00000013395	zranb3	98	52.780	Hippocampus_comes
ENSG00000121988	ZRANB3	90	67.939	ENSIPUG00000013812	zranb3	93	52.991	Ictalurus_punctatus
ENSG00000121988	ZRANB3	99	81.076	ENSSTOG00000010155	ZRANB3	99	81.076	Ictidomys_tridecemlineatus
ENSG00000121988	ZRANB3	94	86.241	ENSJJAG00000018858	-	99	88.372	Jaculus_jaculus
ENSG00000121988	ZRANB3	94	63.391	ENSKMAG00000013326	zranb3	100	53.315	Kryptolebias_marmoratus
ENSG00000121988	ZRANB3	91	68.010	ENSLBEG00000027937	zranb3	95	52.463	Labrus_bergylta
ENSG00000121988	ZRANB3	90	72.519	ENSLOCG00000001673	zranb3	99	53.833	Lepisosteus_oculatus
ENSG00000121988	ZRANB3	99	82.717	ENSLAFG00000015733	ZRANB3	97	90.287	Loxodonta_africana
ENSG00000121988	ZRANB3	100	95.644	ENSMFAG00000034071	ZRANB3	96	95.644	Macaca_fascicularis
ENSG00000121988	ZRANB3	100	94.240	ENSMMUG00000000765	ZRANB3	99	95.902	Macaca_mulatta
ENSG00000121988	ZRANB3	100	94.080	ENSMNEG00000015978	ZRANB3	97	91.855	Macaca_nemestrina
ENSG00000121988	ZRANB3	100	94.720	ENSMLEG00000028200	ZRANB3	99	96.173	Mandrillus_leucophaeus
ENSG00000121988	ZRANB3	86	70.321	ENSMAMG00000004740	zranb3	98	52.465	Mastacembelus_armatus
ENSG00000121988	ZRANB3	91	66.247	ENSMZEG00005003316	zranb3	95	57.622	Maylandia_zebra
ENSG00000121988	ZRANB3	91	65.750	ENSMZEG00005020700	zranb3	94	65.226	Maylandia_zebra
ENSG00000121988	ZRANB3	93	76.108	ENSMGAG00000012454	ZRANB3	99	62.852	Meleagris_gallopavo
ENSG00000121988	ZRANB3	94	83.911	ENSMAUG00000002029	Zranb3	100	77.058	Mesocricetus_auratus
ENSG00000121988	ZRANB3	100	88.159	ENSMICG00000013893	ZRANB3	100	88.159	Microcebus_murinus
ENSG00000121988	ZRANB3	94	80.488	ENSMODG00000000848	ZRANB3	98	72.212	Monodelphis_domestica
ENSG00000121988	ZRANB3	92	67.337	ENSMALG00000009120	zranb3	99	51.293	Monopterus_albus
ENSG00000121988	ZRANB3	94	85.149	ENSMUSG00000036086	Zranb3	100	77.336	Mus_musculus
ENSG00000121988	ZRANB3	94	85.149	MGP_PahariEiJ_G0027778	Zranb3	100	76.873	Mus_pahari
ENSG00000121988	ZRANB3	94	85.149	MGP_SPRETEiJ_G0015349	Zranb3	100	77.243	Mus_spretus
ENSG00000121988	ZRANB3	100	82.669	ENSMPUG00000002528	ZRANB3	100	82.669	Mustela_putorius_furo
ENSG00000121988	ZRANB3	80	90.988	ENSMLUG00000009977	ZRANB3	100	77.521	Myotis_lucifugus
ENSG00000121988	ZRANB3	100	80.481	ENSNGAG00000010584	Zranb3	100	80.481	Nannospalax_galili
ENSG00000121988	ZRANB3	91	65.931	ENSNBRG00000013928	zranb3	99	54.487	Neolamprologus_brichardi
ENSG00000121988	ZRANB3	100	97.405	ENSNLEG00000008561	ZRANB3	100	97.405	Nomascus_leucogenys
ENSG00000121988	ZRANB3	94	74.515	ENSMEUG00000009722	ZRANB3	94	74.652	Notamacropus_eugenii
ENSG00000121988	ZRANB3	97	73.930	ENSOPRG00000001431	ZRANB3	100	73.930	Ochotona_princeps
ENSG00000121988	ZRANB3	94	87.129	ENSODEG00000008027	-	98	86.520	Octodon_degus
ENSG00000121988	ZRANB3	91	68.101	ENSONIG00000012025	zranb3	98	69.512	Oreochromis_niloticus
ENSG00000121988	ZRANB3	94	78.102	ENSOANG00000007986	ZRANB3	97	65.977	Ornithorhynchus_anatinus
ENSG00000121988	ZRANB3	100	78.469	ENSOCUG00000007243	ZRANB3	100	83.660	Oryctolagus_cuniculus
ENSG00000121988	ZRANB3	91	67.430	ENSORLG00000004324	zranb3	100	54.120	Oryzias_latipes
ENSG00000121988	ZRANB3	91	67.176	ENSORLG00020019171	zranb3	98	53.819	Oryzias_latipes_hni
ENSG00000121988	ZRANB3	91	67.176	ENSORLG00015017218	zranb3	100	54.213	Oryzias_latipes_hsok
ENSG00000121988	ZRANB3	91	67.430	ENSOMEG00000000999	zranb3	98	54.480	Oryzias_melastigma
ENSG00000121988	ZRANB3	94	91.089	ENSOARG00000010922	ZRANB3	99	83.996	Ovis_aries
ENSG00000121988	ZRANB3	100	99.166	ENSPPAG00000029480	ZRANB3	100	99.166	Pan_paniscus
ENSG00000121988	ZRANB3	100	84.829	ENSPPRG00000006011	ZRANB3	100	84.829	Panthera_pardus
ENSG00000121988	ZRANB3	100	84.829	ENSPTIG00000014207	ZRANB3	100	84.829	Panthera_tigris_altaica
ENSG00000121988	ZRANB3	100	99.166	ENSPTRG00000012492	ZRANB3	100	99.215	Pan_troglodytes
ENSG00000121988	ZRANB3	100	95.040	ENSPANG00000007838	ZRANB3	100	94.482	Papio_anubis
ENSG00000121988	ZRANB3	93	67.742	ENSPKIG00000011277	zranb3	100	54.712	Paramormyrops_kingsleyae
ENSG00000121988	ZRANB3	93	78.109	ENSPSIG00000005377	ZRANB3	99	65.214	Pelodiscus_sinensis
ENSG00000121988	ZRANB3	82	63.788	ENSPMGG00000011296	zranb3	93	57.143	Periophthalmus_magnuspinnatus
ENSG00000121988	ZRANB3	94	78.529	ENSPEMG00000020506	-	96	78.529	Peromyscus_maniculatus_bairdii
ENSG00000121988	ZRANB3	89	66.234	ENSPMAG00000009550	zranb3	100	53.663	Petromyzon_marinus
ENSG00000121988	ZRANB3	94	81.220	ENSPCIG00000002444	ZRANB3	100	72.901	Phascolarctos_cinereus
ENSG00000121988	ZRANB3	89	68.312	ENSPFOG00000015201	zranb3	98	54.545	Poecilia_formosa
ENSG00000121988	ZRANB3	89	68.571	ENSPLAG00000018028	zranb3	98	53.568	Poecilia_latipinna
ENSG00000121988	ZRANB3	89	64.675	ENSPMEG00000023931	zranb3	95	53.645	Poecilia_mexicana
ENSG00000121988	ZRANB3	89	68.052	ENSPREG00000008183	zranb3	98	52.513	Poecilia_reticulata
ENSG00000121988	ZRANB3	100	97.600	ENSPPYG00000012814	ZRANB3	100	97.405	Pongo_abelii
ENSG00000121988	ZRANB3	95	80.645	ENSPCOG00000003732	ZRANB3	99	80.645	Propithecus_coquereli
ENSG00000121988	ZRANB3	100	79.648	ENSPVAG00000006096	ZRANB3	100	79.648	Pteropus_vampyrus
ENSG00000121988	ZRANB3	91	65.931	ENSPNYG00000008630	zranb3	95	60.090	Pundamilia_nyererei
ENSG00000121988	ZRANB3	80	71.143	ENSPNAG00000013880	zranb3	100	55.345	Pygocentrus_nattereri
ENSG00000121988	ZRANB3	94	83.416	ENSRNOG00000003979	Zranb3	99	75.626	Rattus_norvegicus
ENSG00000121988	ZRANB3	100	85.397	ENSRBIG00000039852	ZRANB3	100	90.430	Rhinopithecus_bieti
ENSG00000121988	ZRANB3	100	93.144	ENSRROG00000038728	ZRANB3	100	93.144	Rhinopithecus_roxellana
ENSG00000121988	ZRANB3	100	90.096	ENSSBOG00000021135	ZRANB3	100	92.451	Saimiri_boliviensis_boliviensis
ENSG00000121988	ZRANB3	94	81.707	ENSSHAG00000016465	ZRANB3	100	83.403	Sarcophilus_harrisii
ENSG00000121988	ZRANB3	94	68.059	ENSSFOG00015014032	zranb3	90	68.059	Scleropages_formosus
ENSG00000121988	ZRANB3	85	67.751	ENSSMAG00000001632	zranb3	98	53.630	Scophthalmus_maximus
ENSG00000121988	ZRANB3	89	70.130	ENSSDUG00000010804	zranb3	98	53.120	Seriola_dumerili
ENSG00000121988	ZRANB3	80	70.201	ENSSLDG00000004579	zranb3	87	70.201	Seriola_lalandi_dorsalis
ENSG00000121988	ZRANB3	88	86.842	ENSSPUG00000004049	ZRANB3	99	78.616	Sphenodon_punctatus
ENSG00000121988	ZRANB3	90	65.394	ENSSPAG00000004802	zranb3	95	65.473	Stegastes_partitus
ENSG00000121988	ZRANB3	100	84.551	ENSSSCG00000015694	ZRANB3	100	84.551	Sus_scrofa
ENSG00000121988	ZRANB3	89	78.364	ENSTGUG00000011743	ZRANB3	100	63.944	Taeniopygia_guttata
ENSG00000121988	ZRANB3	89	68.831	ENSTRUG00000011885	zranb3	98	53.543	Takifugu_rubripes
ENSG00000121988	ZRANB3	88	70.822	ENSTNIG00000010363	zranb3	98	56.209	Tetraodon_nigroviridis
ENSG00000121988	ZRANB3	94	90.842	ENSTTRG00000003932	ZRANB3	100	82.054	Tursiops_truncatus
ENSG00000121988	ZRANB3	80	92.442	ENSUAMG00000018717	-	96	84.941	Ursus_americanus
ENSG00000121988	ZRANB3	94	90.842	ENSUMAG00000005407	ZRANB3	99	89.015	Ursus_maritimus
ENSG00000121988	ZRANB3	94	88.614	ENSVPAG00000001487	ZRANB3	100	80.759	Vicugna_pacos
ENSG00000121988	ZRANB3	94	90.099	ENSVVUG00000006362	ZRANB3	99	88.235	Vulpes_vulpes
ENSG00000121988	ZRANB3	81	78.632	ENSXETG00000019336	ZRANB3	100	80.779	Xenopus_tropicalis
ENSG00000121988	ZRANB3	89	68.312	ENSXMAG00000007875	zranb3	98	53.412	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000733	DNA strand renaturation	-	IEA	Process
GO:0003678	DNA helicase activity	21078962.	IDA	Function
GO:0004520	endodeoxyribonuclease activity	21873635.	IBA	Function
GO:0004520	endodeoxyribonuclease activity	22759634.	IDA	Function
GO:0005515	protein binding	22704558.22705370.22759634.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	-	IDA	Component
GO:0006281	DNA repair	21873635.	IBA	Process
GO:0006281	DNA repair	22759634.	IDA	Process
GO:0006974	cellular response to DNA damage stimulus	21873635.	IBA	Process
GO:0006974	cellular response to DNA damage stimulus	22704558.22705370.22759634.	IDA	Process
GO:0009411	response to UV	22704558.	IDA	Process
GO:0031297	replication fork processing	21873635.	IBA	Process
GO:0031297	replication fork processing	22704558.22705370.	IDA	Process
GO:0032508	DNA duplex unwinding	-	IEA	Process
GO:0036292	DNA rewinding	21873635.	IBA	Process
GO:0036292	DNA rewinding	21078962.22705370.	IDA	Process
GO:0036310	annealing helicase activity	21873635.	IBA	Function
GO:0036310	annealing helicase activity	21078962.22704558.22705370.	IDA	Function
GO:0043596	nuclear replication fork	21873635.	IBA	Component
GO:0043596	nuclear replication fork	22704558.22705370.22759634.	IDA	Component
GO:0045910	negative regulation of DNA recombination	22704558.	IDA	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0048478	replication fork protection	21873635.	IBA	Process
GO:0048478	replication fork protection	22704558.22705370.	IDA	Process
GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	22704558.22705370.22759634.	IDA	Function
GO:0090305	nucleic acid phosphodiester bond hydrolysis	-	IEA	Process