EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000122035 (Gene tree)
Gene ID: 387496
Gene Symbol: RASL11A
Alias: -
Full Name: RAS like family 11 member A
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 3,441 bases
Position: chr13:27,270,327-27,273,767
Accession: 23802
RBP type: canonical RBP
Summary: RASL11A is a member of the small GTPase protein family with a high degree of similarity to RAS (see HRAS, MIM 190020) proteins.[supplied by OMIM, Nov 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000241463	MMR_HSR1	PF01926.23	0.00035	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000475647	RASL11A-202	415	-	-	- (aa)	-	-
ENST00000480803	RASL11A-203	507	-	-	- (aa)	-	-
ENST00000241463	RASL11A-201	1543	XM_024449347	ENSP00000241463	242 (aa)	XP_024305115	Q6T310

Gene Model

Click here to download ENSG00000122035's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000122035	Platelet Aggregation	2.71670245495237E-5	17903294
ENSG00000122035	Electrocardiography	3.47841496835607E-6	17903306
ENSG00000122035	Electrocardiography	8.37850526297385E-6	17903306
ENSG00000122035	Alcoholism	1E-7	21529783
ENSG00000122035	Electrocardiography	8E-6	17903306

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000122035's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000122035	RASL11A	99	92.500	ENSAMEG00000015812	RASL11A	99	92.500	Ailuropoda_melanoleuca
ENSG00000122035	RASL11A	98	72.996	ENSACAG00000003190	RASL11A	100	72.996	Anolis_carolinensis
ENSG00000122035	RASL11A	100	96.694	ENSANAG00000027999	RASL11A	100	96.694	Aotus_nancymaae
ENSG00000122035	RASL11A	100	96.694	ENSCJAG00000019369	RASL11A	100	96.694	Callithrix_jacchus
ENSG00000122035	RASL11A	100	93.388	ENSCAFG00000006798	RASL11A	100	93.388	Canis_familiaris
ENSG00000122035	RASL11A	100	93.388	ENSCAFG00020025312	RASL11A	100	93.388	Canis_lupus_dingo
ENSG00000122035	RASL11A	100	90.083	ENSCPOG00000031264	RASL11A	100	90.083	Cavia_porcellus
ENSG00000122035	RASL11A	100	97.107	ENSCCAG00000021842	RASL11A	100	97.107	Cebus_capucinus
ENSG00000122035	RASL11A	100	99.174	ENSCATG00000033838	RASL11A	100	99.174	Cercocebus_atys
ENSG00000122035	RASL11A	100	98.760	ENSCSAG00000017985	RASL11A	100	98.760	Chlorocebus_sabaeus
ENSG00000122035	RASL11A	98	78.481	ENSCPBG00000020480	RASL11A	52	78.481	Chrysemys_picta_bellii
ENSG00000122035	RASL11A	100	98.347	ENSCANG00000038972	RASL11A	100	98.347	Colobus_angolensis_palliatus
ENSG00000122035	RASL11A	100	91.736	ENSCGRG00001014752	Rasl11a	100	91.736	Cricetulus_griseus_chok1gshd
ENSG00000122035	RASL11A	100	91.736	ENSCGRG00000013361	Rasl11a	100	91.736	Cricetulus_griseus_crigri
ENSG00000122035	RASL11A	100	90.083	ENSDORG00000026016	Rasl11a	100	90.083	Dipodomys_ordii
ENSG00000122035	RASL11A	100	92.149	ENSEASG00005022497	RASL11A	100	92.149	Equus_asinus_asinus
ENSG00000122035	RASL11A	100	92.562	ENSECAG00000012858	RASL11A	100	92.562	Equus_caballus
ENSG00000122035	RASL11A	100	90.496	ENSFCAG00000006749	RASL11A	100	90.496	Felis_catus
ENSG00000122035	RASL11A	98	71.548	ENSFALG00000008621	RASL11A	100	71.548	Ficedula_albicollis
ENSG00000122035	RASL11A	100	90.496	ENSFDAG00000008237	RASL11A	100	90.496	Fukomys_damarensis
ENSG00000122035	RASL11A	98	66.387	ENSGALG00000017099	RASL11A	100	66.387	Gallus_gallus
ENSG00000122035	RASL11A	98	78.059	ENSGAGG00000015067	RASL11A	100	78.059	Gopherus_agassizii
ENSG00000122035	RASL11A	100	99.587	ENSGGOG00000008785	RASL11A	100	99.587	Gorilla_gorilla
ENSG00000122035	RASL11A	98	91.176	ENSHGLG00000005304	RASL11A	98	91.176	Heterocephalus_glaber_female
ENSG00000122035	RASL11A	98	91.176	ENSHGLG00100011809	RASL11A	98	91.176	Heterocephalus_glaber_male
ENSG00000122035	RASL11A	100	94.215	ENSSTOG00000023879	RASL11A	100	94.215	Ictidomys_tridecemlineatus
ENSG00000122035	RASL11A	99	89.583	ENSLAFG00000003673	RASL11A	98	89.583	Loxodonta_africana
ENSG00000122035	RASL11A	100	99.174	ENSMFAG00000044628	RASL11A	100	99.174	Macaca_fascicularis
ENSG00000122035	RASL11A	100	98.760	ENSMNEG00000033345	RASL11A	100	98.760	Macaca_nemestrina
ENSG00000122035	RASL11A	100	99.174	ENSMLEG00000036089	RASL11A	100	99.174	Mandrillus_leucophaeus
ENSG00000122035	RASL11A	100	91.322	ENSMAUG00000019356	Rasl11a	100	91.322	Mesocricetus_auratus
ENSG00000122035	RASL11A	100	93.802	ENSMICG00000029724	RASL11A	100	93.802	Microcebus_murinus
ENSG00000122035	RASL11A	100	92.562	ENSMOCG00000000626	Rasl11a	100	92.562	Microtus_ochrogaster
ENSG00000122035	RASL11A	100	83.471	ENSMODG00000008941	RASL11A	100	83.471	Monodelphis_domestica
ENSG00000122035	RASL11A	100	90.083	MGP_CAROLIEiJ_G0028030	Rasl11a	100	90.083	Mus_caroli
ENSG00000122035	RASL11A	100	89.256	ENSMUSG00000029641	Rasl11a	100	89.256	Mus_musculus
ENSG00000122035	RASL11A	100	90.496	MGP_PahariEiJ_G0024596	Rasl11a	100	90.496	Mus_pahari
ENSG00000122035	RASL11A	100	90.083	MGP_SPRETEiJ_G0029028	Rasl11a	100	90.083	Mus_spretus
ENSG00000122035	RASL11A	100	92.975	ENSMPUG00000009362	RASL11A	100	92.975	Mustela_putorius_furo
ENSG00000122035	RASL11A	100	94.215	ENSMLUG00000016335	RASL11A	100	94.215	Myotis_lucifugus
ENSG00000122035	RASL11A	100	92.562	ENSNGAG00000021721	Rasl11a	100	92.562	Nannospalax_galili
ENSG00000122035	RASL11A	100	100.000	ENSNLEG00000000329	RASL11A	100	100.000	Nomascus_leucogenys
ENSG00000122035	RASL11A	100	90.496	ENSODEG00000005775	RASL11A	100	90.496	Octodon_degus
ENSG00000122035	RASL11A	100	91.322	ENSOCUG00000008121	RASL11A	100	91.322	Oryctolagus_cuniculus
ENSG00000122035	RASL11A	98	93.697	ENSOGAG00000008177	RASL11A	98	93.697	Otolemur_garnettii
ENSG00000122035	RASL11A	100	100.000	ENSPPAG00000027996	RASL11A	100	100.000	Pan_paniscus
ENSG00000122035	RASL11A	100	100.000	ENSPTRG00000005729	RASL11A	100	100.000	Pan_troglodytes
ENSG00000122035	RASL11A	100	98.760	ENSPANG00000004651	RASL11A	100	98.760	Papio_anubis
ENSG00000122035	RASL11A	98	78.571	ENSPSIG00000011613	RASL11A	100	78.571	Pelodiscus_sinensis
ENSG00000122035	RASL11A	100	92.149	ENSPEMG00000004475	Rasl11a	100	92.149	Peromyscus_maniculatus_bairdii
ENSG00000122035	RASL11A	100	100.000	ENSPPYG00000005234	RASL11A	100	100.000	Pongo_abelii
ENSG00000122035	RASL11A	100	94.215	ENSPCOG00000009447	RASL11A	100	94.215	Propithecus_coquereli
ENSG00000122035	RASL11A	100	91.322	ENSRNOG00000000956	Rasl11a	100	91.322	Rattus_norvegicus
ENSG00000122035	RASL11A	100	98.347	ENSRBIG00000043749	RASL11A	100	98.347	Rhinopithecus_bieti
ENSG00000122035	RASL11A	100	98.347	ENSRROG00000032810	RASL11A	100	98.347	Rhinopithecus_roxellana
ENSG00000122035	RASL11A	100	96.694	ENSSBOG00000025363	RASL11A	100	96.694	Saimiri_boliviensis_boliviensis
ENSG00000122035	RASL11A	100	82.231	ENSSHAG00000016468	RASL11A	100	82.231	Sarcophilus_harrisii
ENSG00000122035	RASL11A	100	88.066	ENSSARG00000011269	RASL11A	100	88.066	Sorex_araneus
ENSG00000122035	RASL11A	99	77.917	ENSSPUG00000005315	RASL11A	100	77.917	Sphenodon_punctatus
ENSG00000122035	RASL11A	100	94.215	ENSUAMG00000016809	RASL11A	100	94.215	Ursus_americanus
ENSG00000122035	RASL11A	100	93.388	ENSVVUG00000009191	RASL11A	100	93.388	Vulpes_vulpes
ENSG00000122035	RASL11A	99	68.313	ENSXETG00000030983	RASL11A	97	68.313	Xenopus_tropicalis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003924	GTPase activity	-	IEA	Function
GO:0005525	GTP binding	-	IEA	Function
GO:0005730	nucleolus	-	ISS	Component
GO:0007165	signal transduction	-	IEA	Process
GO:0016020	membrane	-	IEA	Component
GO:0045943	positive regulation of transcription by RNA polymerase I	-	ISS	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
15033445	RASL11A, member of a novel small monomeric GTPase gene family, is down-regulated in prostate tumors.	Biochem Biophys Res Commun	2004 Apr 9	Louro R	-

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BRCA	chr13	27273335	Missense_Mutation	novel	Q190H	0.15
BRCA	chr13	27270898	5'UTR	novel		0.46
BRCA	chr13	27273096	Silent	rs753163681	L111L	0.19
COAD	chr13	27273374	Frame_Shift_Ins	novel	*E205Gfs56**	0.47
COAD	chr13	27273248	Silent	rs758061495	D161D	0.32
COAD	chr13	27273041	Frame_Shift_Del	NA	*Q94Rfs72**	0.3	MMR_HSR1
COAD	chr13	27271668	Missense_Mutation	novel	E71K	0.3	MMR_HSR1
COAD	chr13	27271535	Missense_Mutation	rs372800147	N59T	0.32	MMR_HSR1
ESCA	chr13	27273691	3'Flank	novel		0.58
GBM	chr13	27271701	Frame_Shift_Del	novel	*T82Lfs84**	0.22	MMR_HSR1
GBM	chr13	27273102	Missense_Mutation	novel	Y113H	0.16	MMR_HSR1
GBM	chr13	27273549	3'UTR	novel		0.13
HNSC	chr13	27271539	Splice_Region	novel	T60T	0.08
HNSC	chr13	27270936	5'UTR	novel		0.5
HNSC	chr13	27273493	Silent	novel	*243*	0.19
LAML	chr13	27273102	Missense_Mutation	novel	Y113H	0.03	MMR_HSR1
LIHC	chr13	27271667	Frame_Shift_Ins	novel	*E71Tfs62**	0.08	MMR_HSR1
LIHC	chr13	27273224	Frame_Shift_Del	novel	*H153Qfs13**	0.72
LIHC	chr13	27273526	3'UTR	novel		0.47
LUAD	chr13	27271023	Missense_Mutation	novel	D27N	0.27
LUAD	chr13	27273232	Missense_Mutation	novel	Q156L	0.15
LUAD	chr13	27273547	3'UTR	novel		0.31
LUSC	chr13	27273308	Missense_Mutation	NA	N181K	0.31
LUSC	chr13	27273120	Missense_Mutation	novel	D119Y	0.19	MMR_HSR1
LUSC	chr13	27273529	3'UTR	novel		0.21
LUSC	chr13	27273207	Frame_Shift_Del	novel	*K148Rfs18**	0.22	MMR_HSR1
LUSC	chr13	27273288	Missense_Mutation	NA	E175Q	0.35
OV	chr13	27273290	Missense_Mutation	novel	E175D	0.09
OV	chr13	27271523	Missense_Mutation	novel	D55G	0.05	MMR_HSR1
OV	chr13	27273137	Missense_Mutation	novel	I124M	0.09	MMR_HSR1
PRAD	chr13	27273512	3'UTR	novel		0.09
READ	chr13	27273190	Missense_Mutation	novel	V142A	0.18	MMR_HSR1
SARC	chr13	27273197	Silent	rs149565737	I144I	0.34
SKCM	chr13	27273041	Silent	NA	L92L	0.27
SKCM	chr13	27273215	Silent	NA	D150D	0.32
SKCM	chr13	27271036	Missense_Mutation	novel	A31V	0.33	MMR_HSR1
SKCM	chr13	27273137	Silent	NA	I124I	0.14
SKCM	chr13	27273462	Missense_Mutation	NA	P233S	0.18
SKCM	chr13	27273150	Nonsense_Mutation	NA	Q129*	0.41	MMR_HSR1
SKCM	chr13	27273050	Silent	novel	V95V	0.42
STAD	chr13	27273303	Missense_Mutation	NA	E180K	0.23
STAD	chr13	27273139	Missense_Mutation	rs747958383	R125Q	0.2	MMR_HSR1
STAD	chr13	27271713	Missense_Mutation	NA	V86I	0.23	MMR_HSR1
STAD	chr13	27273143	Silent	NA	P126P	0.73
STAD	chr13	27273228	Missense_Mutation	rs767537468	R155W	0.19
UCEC	chr13	27273311	Silent	rs138870499	Y182Y	0.28
UCEC	chr13	27273586	3'UTR	rs778595217		0.26
UCEC	chr13	27273339	Missense_Mutation	novel	L192F	0.35
UCEC	chr13	27273198	Missense_Mutation	novel	V145M	0.48	MMR_HSR1
UCEC	chr13	27273187	Missense_Mutation	novel	P141L	0.22	MMR_HSR1
UCEC	chr13	27271698	Missense_Mutation	NA	D81N	0.27	MMR_HSR1
UCEC	chr13	27273421	Missense_Mutation	novel	N219I	0.2
UCEC	chr13	27273271	Missense_Mutation	novel	L169P	0.4
UCEC	chr13	27273691	3'Flank	novel		0.61
UCEC	chr13	27273312	Missense_Mutation	rs200613411	E183K	0.43
UCEC	chr13	27273198	Missense_Mutation	novel	V145M	0.24	MMR_HSR1
UCEC	chr13	27273560	3'UTR	rs756070292		0.33
UCEC	chr13	27273661	3'UTR	novel		0.54
UCEC	chr13	27273412	Missense_Mutation	rs762765599	R216H	0.37
UCEC	chr13	27273562	3'UTR	novel		0.25
UCEC	chr13	27271666	Missense_Mutation	novel	V70A	0.23	MMR_HSR1
UCEC	chr13	27273139	Missense_Mutation	rs747958383	R125Q	0.14	MMR_HSR1
UCEC	chr13	27273302	Silent	rs774803111	S179S	0.35
UCEC	chr13	27273261	Missense_Mutation	novel	A166T	0.56
UCEC	chr13	27273519	3'UTR	novel		0.2
UCEC	chr13	27273560	3'UTR	rs756070292		0.36
UCEC	chr13	27273312	Missense_Mutation	rs200613411	E183K	0.28
UCEC	chr13	27273463	Missense_Mutation	novel	P233L	0.38
UCEC	chr13	27273590	3'UTR	novel		0.38
UCEC	chr13	27273198	Missense_Mutation	novel	V145M	0.2	MMR_HSR1
UCEC	chr13	27273302	Silent	rs774803111	S179S	0.25
UCEC	chr13	27273382	Missense_Mutation	novel	R206I	0.44
UCEC	chr13	27273311	Silent	rs138870499	Y182Y	0.26
UCS	chr13	27273348	Nonsense_Mutation	NA	E195*	0.36

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KIRC	DEL	0.1174	0.031318
MESO	DEL	0.4253	0.0010209
THCA	DEL	0.0301	0.011063

Survival Analysis

Cancer	P-value	Q-value
SARC	0.019	Kaplan-Meier Survival Analysis
MESO	0.00011	Kaplan-Meier Survival Analysis
UCS	0.0036	Kaplan-Meier Survival Analysis
HNSC	0.049	Kaplan-Meier Survival Analysis
KIRP	0.013	Kaplan-Meier Survival Analysis
LAML	0.017	Kaplan-Meier Survival Analysis
LUAD	0.0011	Kaplan-Meier Survival Analysis
UVM	0.002	Kaplan-Meier Survival Analysis