EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000122085 (Gene tree)
Gene ID: 130916
Gene Symbol: MTERF4
Alias: MGC61716|MTERFD2
Full Name: mitochondrial transcription termination factor 4
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 30,191 bases
Position: chr2:241,072,169-241,102,359
Accession: 28785
RBP type: canonical RBP
Summary: (Mitochondrial Transcription Termination Factor 4) is a Protein Coding gene. Among its related pathways are rRNA processing in the mitochondrion and Gene Expression. Gene Ontology (GO) annotations related to this gene include double-stranded DNA binding and rRNA binding.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000375840	mTERF	PF02536.14	4.4e-17	1	1
ENSP00000480378	mTERF	PF02536.14	4.4e-17	1	1
ENSP00000385630	mTERF	PF02536.14	4.9e-11	1	1
ENSP00000409023	mTERF	PF02536.14	8.2e-11	1	1
ENSP00000414989	mTERF	PF02536.14	1.8e-08	1	1
ENSP00000401409	mTERF	PF02536.14	8.8e-07	1	1
ENSP00000384998	mTERF	PF02536.14	2.4e-05	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
23022348	Structure of the essential MTERF4:NSUN4 protein complex reveals how an MTERF protein collaborates to facilitate rRNA modification.	Structure	2012 Nov 7	Yakubovskaya E	doi: 10.1016/j.str.2012.08.027
22949673	Structure of the human MTERF4-NSUN4 protein complex that regulates mitochondrial ribosome biogenesis.	Proc Natl Acad Sci U S A	2012 Sep 18	Spahr H	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000391980	MTERF4-202	1637	-	ENSP00000375840	381 (aa)	-	Q7Z6M4
ENST00000493169	MTERF4-219	576	-	-	- (aa)	-	-
ENST00000480298	MTERF4-217	585	-	-	- (aa)	-	-
ENST00000475860	MTERF4-214	789	-	-	- (aa)	-	-
ENST00000479205	MTERF4-216	712	-	-	- (aa)	-	-
ENST00000455202	MTERF4-211	2626	NR_028051	-	- (aa)	-	-
ENST00000434791	MTERF4-208	549	-	ENSP00000393063	151 (aa)	-	C9JX74
ENST00000476564	MTERF4-215	614	-	-	- (aa)	-	-
ENST00000464344	MTERF4-213	3993	-	-	- (aa)	-	-
ENST00000488567	MTERF4-218	3854	-	-	- (aa)	-	-
ENST00000496878	MTERF4-221	2269	-	-	- (aa)	-	-
ENST00000401626	MTERF4-203	561	XM_006712292	ENSP00000385183	182 (aa)	XP_006712355	B5MBW3
ENST00000614476	MTERF4-222	4524	XM_017003379	ENSP00000480378	381 (aa)	XP_016858868	Q7Z6M4
ENST00000424798	MTERF4-207	797	-	ENSP00000409023	257 (aa)	-	H7C316
ENST00000241527	MTERF4-201	4529	-	ENSP00000241527	381 (aa)	-	Q7Z6M4
ENST00000460915	MTERF4-212	571	-	-	- (aa)	-	-
ENST00000439144	MTERF4-209	583	-	ENSP00000414989	187 (aa)	-	C9JNJ7
ENST00000406593	MTERF4-204	802	XM_017003391	ENSP00000384998	193 (aa)	XP_016858880	B4DFP7
ENST00000449133	MTERF4-210	534	-	ENSP00000413346	107 (aa)	-	H7C3Q3
ENST00000495694	MTERF4-220	909	XM_024452707	ENSP00000419315	249 (aa)	XP_024308475	E7EW93
ENST00000414146	MTERF4-206	457	-	ENSP00000401409	152 (aa)	-	H7C1N9
ENST00000407095	MTERF4-205	799	-	ENSP00000385630	252 (aa)	-	B4DKD5

Gene Model

Click here to download ENSG00000122085's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000122085	Sex Hormone-Binding Globulin	3E-6	22675492
ENSG00000122085	Bipolar Disorder	4E-7	25944848
ENSG00000122085	Depressive Disorder	4E-7	25944848
ENSG00000122085	Psychotropic Drugs	4E-7	25944848
ENSG00000122085	Schizophrenia	4E-7	25944848
ENSG00000122085	Antipsychotic Agents	4E-7	25944848

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000122085	rs2302045	2	241081801	T	Pharmacokinetics of antipsychotic drugs in severe mental disorder (concentration drug ratio)	25944848	[NR] unit decrease	0.4064	EFO_0003761\|EFO_0000692\|EFO_0000289\|EFO_0007635\|GO_0097332
ENSG00000122085	rs6437234	2	241079873	T	Blood protein levels	29875488	[0.77-0.89] unit increase	0.83	EFO_0007937
ENSG00000122085	rs6721345	2	241073314	A	Sex hormone-binding globulin levels	22675492	[NR] unit increase	1.13	EFO_0004696

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000122085's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000122085	MTERF4	83	50.323	ENSAPOG00000023930	si:dkeyp-94h10.5	65	45.455	Acanthochromis_polyacanthus
ENSG00000122085	MTERF4	100	66.887	ENSAMEG00000016670	MTERF4	92	73.602	Ailuropoda_melanoleuca
ENSG00000122085	MTERF4	83	52.258	ENSACIG00000004919	si:dkeyp-94h10.5	77	45.020	Amphilophus_citrinellus
ENSG00000122085	MTERF4	83	49.677	ENSAOCG00000024498	si:dkeyp-94h10.5	69	45.299	Amphiprion_ocellaris
ENSG00000122085	MTERF4	83	49.677	ENSAPEG00000009622	si:dkeyp-94h10.5	66	45.299	Amphiprion_percula
ENSG00000122085	MTERF4	87	45.833	ENSATEG00000013599	si:dkeyp-94h10.5	69	42.449	Anabas_testudineus
ENSG00000122085	MTERF4	82	55.063	ENSACAG00000002023	MTERF4	75	50.202	Anolis_carolinensis
ENSG00000122085	MTERF4	100	84.768	ENSANAG00000026147	MTERF4	98	84.239	Aotus_nancymaae
ENSG00000122085	MTERF4	83	54.194	ENSACLG00000000369	si:dkeyp-94h10.5	71	46.939	Astatotilapia_calliptera
ENSG00000122085	MTERF4	90	47.701	ENSAMXG00000036876	si:dkeyp-94h10.5	69	46.121	Astyanax_mexicanus
ENSG00000122085	MTERF4	87	80.247	ENSBTAG00000000784	MTERF4	96	73.433	Bos_taurus
ENSG00000122085	MTERF4	100	80.795	ENSCJAG00000006346	MTERF4	93	86.726	Callithrix_jacchus
ENSG00000122085	MTERF4	100	66.887	ENSCHIG00000022070	MTERF4	93	73.860	Capra_hircus
ENSG00000122085	MTERF4	77	84.000	ENSTSYG00000012283	-	92	82.237	Carlito_syrichta
ENSG00000122085	MTERF4	80	80.537	ENSCAPG00000015425	MTERF4	92	61.765	Cavia_aperea
ENSG00000122085	MTERF4	100	65.563	ENSCPOG00000025700	MTERF4	92	73.016	Cavia_porcellus
ENSG00000122085	MTERF4	100	82.119	ENSCCAG00000028780	MTERF4	89	86.726	Cebus_capucinus
ENSG00000122085	MTERF4	100	92.053	ENSCATG00000021725	MTERF4	92	94.395	Cercocebus_atys
ENSG00000122085	MTERF4	100	66.887	ENSCLAG00000002565	MTERF4	81	72.050	Chinchilla_lanigera
ENSG00000122085	MTERF4	100	92.715	ENSCSAG00000005845	MTERF4	92	94.985	Chlorocebus_sabaeus
ENSG00000122085	MTERF4	85	58.491	ENSCPBG00000014396	MTERF4	90	46.012	Chrysemys_picta_bellii
ENSG00000122085	MTERF4	99	92.430	ENSCANG00000039696	MTERF4	100	92.430	Colobus_angolensis_palliatus
ENSG00000122085	MTERF4	87	74.074	ENSCGRG00001006818	Mterf4	94	68.955	Cricetulus_griseus_chok1gshd
ENSG00000122085	MTERF4	92	73.837	ENSCGRG00000018329	Mterf4	93	69.799	Cricetulus_griseus_crigri
ENSG00000122085	MTERF4	92	48.876	ENSCSEG00000015693	si:dkeyp-94h10.5	75	42.593	Cynoglossus_semilaevis
ENSG00000122085	MTERF4	83	50.968	ENSCVAG00000020454	si:dkeyp-94h10.5	78	46.694	Cyprinodon_variegatus
ENSG00000122085	MTERF4	85	50.303	ENSDARG00000079124	MTERF4	78	42.460	Danio_rerio
ENSG00000122085	MTERF4	100	68.212	ENSDNOG00000004661	-	91	74.534	Dasypus_novemcinctus
ENSG00000122085	MTERF4	99	59.333	ENSDNOG00000043043	-	91	64.907	Dasypus_novemcinctus
ENSG00000122085	MTERF4	100	65.563	ENSDORG00000028393	Mterf4	96	69.512	Dipodomys_ordii
ENSG00000122085	MTERF4	100	70.861	ENSEASG00005008185	MTERF4	91	76.087	Equus_asinus_asinus
ENSG00000122085	MTERF4	100	70.861	ENSECAG00000011622	MTERF4	92	76.087	Equus_caballus
ENSG00000122085	MTERF4	100	69.536	ENSFCAG00000010451	MTERF4	96	73.591	Felis_catus
ENSG00000122085	MTERF4	100	68.874	ENSFDAG00000020581	MTERF4	93	74.455	Fukomys_damarensis
ENSG00000122085	MTERF4	83	50.323	ENSFHEG00000020077	si:dkeyp-94h10.5	70	44.118	Fundulus_heteroclitus
ENSG00000122085	MTERF4	86	45.000	ENSGMOG00000011871	si:dkeyp-94h10.5	81	46.061	Gadus_morhua
ENSG00000122085	MTERF4	83	51.613	ENSGAFG00000009227	si:dkeyp-94h10.5	73	44.706	Gambusia_affinis
ENSG00000122085	MTERF4	83	51.613	ENSGACG00000015039	si:dkeyp-94h10.5	83	51.220	Gasterosteus_aculeatus
ENSG00000122085	MTERF4	88	59.146	ENSGAGG00000002040	MTERF4	67	52.988	Gopherus_agassizii
ENSG00000122085	MTERF4	100	96.689	ENSGGOG00000036917	MTERF4	99	96.620	Gorilla_gorilla
ENSG00000122085	MTERF4	83	52.903	ENSHBUG00000023242	si:dkeyp-94h10.5	71	46.122	Haplochromis_burtoni
ENSG00000122085	MTERF4	100	68.874	ENSHGLG00000003898	MTERF4	84	73.832	Heterocephalus_glaber_female
ENSG00000122085	MTERF4	100	68.874	ENSHGLG00100012438	MTERF4	84	73.832	Heterocephalus_glaber_male
ENSG00000122085	MTERF4	86	50.311	ENSHCOG00000018545	si:dkeyp-94h10.5	66	45.852	Hippocampus_comes
ENSG00000122085	MTERF4	80	48.993	ENSIPUG00000009895	Mterfd2	75	42.471	Ictalurus_punctatus
ENSG00000122085	MTERF4	100	62.252	ENSJJAG00000000477	Mterf4	94	72.050	Jaculus_jaculus
ENSG00000122085	MTERF4	83	48.387	ENSKMAG00000004723	si:dkeyp-94h10.5	65	45.022	Kryptolebias_marmoratus
ENSG00000122085	MTERF4	84	52.532	ENSLBEG00000023319	si:dkeyp-94h10.5	66	47.619	Labrus_bergylta
ENSG00000122085	MTERF4	83	53.846	ENSLOCG00000006029	si:dkeyp-94h10.5	69	46.025	Lepisosteus_oculatus
ENSG00000122085	MTERF4	100	70.861	ENSLAFG00000021960	MTERF4	93	77.640	Loxodonta_africana
ENSG00000122085	MTERF4	100	93.377	ENSMFAG00000026775	MTERF4	92	94.395	Macaca_fascicularis
ENSG00000122085	MTERF4	100	93.377	ENSMMUG00000006835	MTERF4	100	90.347	Macaca_mulatta
ENSG00000122085	MTERF4	100	93.377	ENSMNEG00000040061	MTERF4	99	94.538	Macaca_nemestrina
ENSG00000122085	MTERF4	100	92.715	ENSMLEG00000035945	MTERF4	100	87.500	Mandrillus_leucophaeus
ENSG00000122085	MTERF4	82	49.020	ENSMAMG00000011201	si:dkeyp-94h10.5	87	43.723	Mastacembelus_armatus
ENSG00000122085	MTERF4	83	54.194	ENSMZEG00005019644	si:dkeyp-94h10.5	71	46.939	Maylandia_zebra
ENSG00000122085	MTERF4	100	58.940	ENSMAUG00000000081	Mterf4	97	68.657	Mesocricetus_auratus
ENSG00000122085	MTERF4	100	74.172	ENSMICG00000044756	MTERF4	90	77.353	Microcebus_murinus
ENSG00000122085	MTERF4	90	70.588	ENSMOCG00000010203	Mterf4	96	67.463	Microtus_ochrogaster
ENSG00000122085	MTERF4	85	50.314	ENSMMOG00000018988	si:dkeyp-94h10.5	69	45.887	Mola_mola
ENSG00000122085	MTERF4	80	65.101	ENSMODG00000015998	-	95	62.424	Monodelphis_domestica
ENSG00000122085	MTERF4	83	51.613	ENSMALG00000015744	si:dkeyp-94h10.5	77	46.581	Monopterus_albus
ENSG00000122085	MTERF4	100	56.954	MGP_CAROLIEiJ_G0014452	Mterf4	97	65.970	Mus_caroli
ENSG00000122085	MTERF4	100	56.291	ENSMUSG00000026273	Mterf4	100	59.583	Mus_musculus
ENSG00000122085	MTERF4	100	56.954	MGP_PahariEiJ_G0027688	Mterf4	95	66.567	Mus_pahari
ENSG00000122085	MTERF4	100	56.954	MGP_SPRETEiJ_G0015256	Mterf4	98	66.567	Mus_spretus
ENSG00000122085	MTERF4	100	65.563	ENSMPUG00000000155	MTERF4	91	74.224	Mustela_putorius_furo
ENSG00000122085	MTERF4	100	66.887	ENSMLUG00000005579	MTERF4	92	72.981	Myotis_lucifugus
ENSG00000122085	MTERF4	100	66.887	ENSNGAG00000023724	Mterf4	93	74.121	Nannospalax_galili
ENSG00000122085	MTERF4	82	53.595	ENSNBRG00000017494	si:dkeyp-94h10.5	87	47.186	Neolamprologus_brichardi
ENSG00000122085	MTERF4	100	96.026	ENSNLEG00000013727	MTERF4	92	95.575	Nomascus_leucogenys
ENSG00000122085	MTERF4	87	67.284	ENSMEUG00000000405	-	91	53.651	Notamacropus_eugenii
ENSG00000122085	MTERF4	86	75.776	ENSODEG00000010009	MTERF4	92	68.889	Octodon_degus
ENSG00000122085	MTERF4	92	50.000	ENSONIG00000010063	si:dkeyp-94h10.5	71	46.939	Oreochromis_niloticus
ENSG00000122085	MTERF4	81	67.763	ENSOANG00000015611	-	91	51.368	Ornithorhynchus_anatinus
ENSG00000122085	MTERF4	90	76.471	ENSOCUG00000025170	-	96	73.251	Oryctolagus_cuniculus
ENSG00000122085	MTERF4	82	52.288	ENSORLG00000015812	si:dkeyp-94h10.5	66	46.288	Oryzias_latipes
ENSG00000122085	MTERF4	82	51.634	ENSORLG00015015453	si:dkeyp-94h10.5	68	45.852	Oryzias_latipes_hsok
ENSG00000122085	MTERF4	100	66.225	ENSOGAG00000024565	MTERF4	98	72.647	Otolemur_garnettii
ENSG00000122085	MTERF4	100	66.225	ENSOARG00000018079	MTERF4	96	72.836	Ovis_aries
ENSG00000122085	MTERF4	100	96.026	ENSPPAG00000041007	MTERF4	99	95.276	Pan_paniscus
ENSG00000122085	MTERF4	93	76.705	ENSPPRG00000016102	MTERF4	95	74.184	Panthera_pardus
ENSG00000122085	MTERF4	93	76.136	ENSPTIG00000012832	MTERF4	95	73.333	Panthera_tigris_altaica
ENSG00000122085	MTERF4	100	96.026	ENSPTRG00000013116	MTERF4	99	95.538	Pan_troglodytes
ENSG00000122085	MTERF4	100	92.053	ENSPANG00000014465	MTERF4	92	93.215	Papio_anubis
ENSG00000122085	MTERF4	80	54.362	ENSPKIG00000014785	si:dkeyp-94h10.5	76	47.009	Paramormyrops_kingsleyae
ENSG00000122085	MTERF4	81	63.576	ENSPSIG00000015228	MTERF4	61	55.696	Pelodiscus_sinensis
ENSG00000122085	MTERF4	88	65.663	ENSPCIG00000015434	-	99	52.260	Phascolarctos_cinereus
ENSG00000122085	MTERF4	83	50.323	ENSPFOG00000006397	si:dkeyp-94h10.5	69	46.154	Poecilia_formosa
ENSG00000122085	MTERF4	83	50.968	ENSPLAG00000008481	si:dkeyp-94h10.5	69	46.581	Poecilia_latipinna
ENSG00000122085	MTERF4	83	50.968	ENSPMEG00000011545	si:dkeyp-94h10.5	69	47.009	Poecilia_mexicana
ENSG00000122085	MTERF4	83	50.968	ENSPREG00000016508	si:dkeyp-94h10.5	68	47.186	Poecilia_reticulata
ENSG00000122085	MTERF4	99	94.000	ENSPPYG00000013347	MTERF4	93	95.870	Pongo_abelii
ENSG00000122085	MTERF4	100	72.848	ENSPCAG00000002438	-	69	70.482	Procavia_capensis
ENSG00000122085	MTERF4	100	77.483	ENSPCOG00000014892	MTERF4	93	80.000	Propithecus_coquereli
ENSG00000122085	MTERF4	83	53.548	ENSPNYG00000009105	si:dkeyp-94h10.5	70	47.009	Pundamilia_nyererei
ENSG00000122085	MTERF4	78	48.630	ENSPNAG00000006761	si:dkeyp-94h10.5	91	42.174	Pygocentrus_nattereri
ENSG00000122085	MTERF4	86	73.125	ENSRNOG00000037376	Mterf4	98	64.638	Rattus_norvegicus
ENSG00000122085	MTERF4	100	90.728	ENSRBIG00000035413	MTERF4	98	92.766	Rhinopithecus_bieti
ENSG00000122085	MTERF4	100	90.728	ENSRROG00000025293	MTERF4	100	88.800	Rhinopithecus_roxellana
ENSG00000122085	MTERF4	100	82.781	ENSSBOG00000025209	MTERF4	83	84.384	Saimiri_boliviensis_boliviensis
ENSG00000122085	MTERF4	70	69.231	ENSSHAG00000011545	-	82	70.149	Sarcophilus_harrisii
ENSG00000122085	MTERF4	80	50.336	ENSSFOG00015004597	mterf4	72	44.444	Scleropages_formosus
ENSG00000122085	MTERF4	83	49.677	ENSSMAG00000001231	si:dkeyp-94h10.5	70	43.210	Scophthalmus_maximus
ENSG00000122085	MTERF4	82	50.968	ENSSDUG00000017757	si:dkeyp-94h10.5	85	45.455	Seriola_dumerili
ENSG00000122085	MTERF4	83	50.968	ENSSLDG00000014641	si:dkeyp-94h10.5	68	45.299	Seriola_lalandi_dorsalis
ENSG00000122085	MTERF4	85	59.119	ENSSPUG00000017358	MTERF4	84	49.823	Sphenodon_punctatus
ENSG00000122085	MTERF4	84	51.899	ENSSPAG00000015366	si:dkeyp-94h10.5	69	47.009	Stegastes_partitus
ENSG00000122085	MTERF4	100	62.914	ENSSSCG00000016380	MTERF4	84	67.552	Sus_scrofa
ENSG00000122085	MTERF4	79	48.980	ENSTRUG00000014052	si:dkeyp-94h10.5	70	42.083	Takifugu_rubripes
ENSG00000122085	MTERF4	83	47.097	ENSTNIG00000000278	si:dkeyp-94h10.5	90	42.797	Tetraodon_nigroviridis
ENSG00000122085	MTERF4	88	80.000	ENSTBEG00000010790	MTERF4	97	68.468	Tupaia_belangeri
ENSG00000122085	MTERF4	100	68.212	ENSTTRG00000015232	MTERF4	94	74.224	Tursiops_truncatus
ENSG00000122085	MTERF4	100	67.550	ENSUAMG00000019040	MTERF4	91	74.534	Ursus_americanus
ENSG00000122085	MTERF4	89	41.477	ENSXETG00000032078	MTERF4	73	38.528	Xenopus_tropicalis
ENSG00000122085	MTERF4	83	52.903	ENSXCOG00000001754	si:dkeyp-94h10.5	75	47.436	Xiphophorus_couchianus
ENSG00000122085	MTERF4	83	53.548	ENSXMAG00000027001	si:dkeyp-94h10.5	75	46.304	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003690	double-stranded DNA binding	-	IEA	Function
GO:0005515	protein binding	21531335.22949673.23022348.	IPI	Function
GO:0005739	mitochondrion	21873635.	IBA	Component
GO:0005739	mitochondrion	-	IDA	Component
GO:0005759	mitochondrial matrix	-	TAS	Component
GO:0005762	mitochondrial large ribosomal subunit	21531335.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0006355	regulation of transcription, DNA-templated	-	IEA	Process
GO:0006390	mitochondrial transcription	21873635.	IBA	Process
GO:0006626	protein targeting to mitochondrion	-	IEA	Process
GO:0007507	heart development	-	IEA	Process
GO:0019843	rRNA binding	21531335.	IDA	Function
GO:0031167	rRNA methylation	-	TAS	Process
GO:0032543	mitochondrial translation	21873635.	IBA	Process
GO:0043010	camera-type eye development	-	IEA	Process
GO:0061668	mitochondrial ribosome assembly	21873635.	IBA	Process