EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000122126 (Gene tree)
Gene ID: 4952
Gene Symbol: OCRL
Alias: OCRL1
Full Name: OCRL inositol polyphosphate-5-phosphatase
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 59,822 bases
Position: chrX:129,532,740-129,592,561
Accession: 8108
RBP type: canonical RBP
Summary: This gene encodes an inositol polyphosphate 5-phosphatase. This protein is involved in regulating membrane trafficking and is located in numerous subcellular locations including the trans-Golgi network, clathrin-coated vesicles and, endosomes and the plasma membrane. This protein may also play a role in primary cilium formation. Mutations in this gene cause oculocerebrorenal syndrome of Lowe and also Dent disease. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000349635	Exo_endo_phos	PF03372.23	1.1e-15	1	1
ENSP00000360154	Exo_endo_phos	PF03372.23	1.1e-15	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000463271	OCRL-203	856	-	-	- (aa)	-	-
ENST00000486673	OCRL-204	942	-	-	- (aa)	-	-
ENST00000647245	OCRL-207	4325	-	ENSP00000495615	466 (aa)	-	A0A2R8YG38
ENST00000357121	OCRL-201	5138	-	ENSP00000349635	893 (aa)	-	Q01968
ENST00000646914	OCRL-206	4079	-	ENSP00000493809	286 (aa)	-	A0A2R8YCN4
ENST00000371113	OCRL-202	5162	XM_005262422	ENSP00000360154	901 (aa)	XP_005262479	Q01968
ENST00000646010	OCRL-205	5021	-	ENSP00000494940	69 (aa)	-	A0A2R8YF88

Gene Model

Click here to download ENSG00000122126's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00562	Inositol phosphate metabolism	KEGG
hsa01100	Metabolic pathways	KEGG
hsa04070	Phosphatidylinositol signaling system	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000122126's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000122126	OCRL	95	75.368	ENSAPOG00000012272	ocrl	99	61.828	Acanthochromis_polyacanthus
ENSG00000122126	OCRL	99	95.388	ENSAMEG00000015161	OCRL	100	95.388	Ailuropoda_melanoleuca
ENSG00000122126	OCRL	95	73.162	ENSACIG00000013165	ocrl	98	61.851	Amphilophus_citrinellus
ENSG00000122126	OCRL	95	75.000	ENSAOCG00000013381	ocrl	99	62.459	Amphiprion_ocellaris
ENSG00000122126	OCRL	95	75.000	ENSAPEG00000006006	ocrl	98	61.266	Amphiprion_percula
ENSG00000122126	OCRL	95	73.529	ENSATEG00000018445	ocrl	99	59.629	Anabas_testudineus
ENSG00000122126	OCRL	83	85.232	ENSAPLG00000014140	OCRL	100	70.888	Anas_platyrhynchos
ENSG00000122126	OCRL	95	85.662	ENSACAG00000000936	OCRL	99	78.912	Anolis_carolinensis
ENSG00000122126	OCRL	100	96.559	ENSANAG00000025371	OCRL	100	96.559	Aotus_nancymaae
ENSG00000122126	OCRL	95	72.794	ENSACLG00000001194	ocrl	99	59.320	Astatotilapia_calliptera
ENSG00000122126	OCRL	95	74.725	ENSAMXG00000000239	ocrl	99	60.165	Astyanax_mexicanus
ENSG00000122126	OCRL	98	94.521	ENSBTAG00000018247	OCRL	100	94.521	Bos_taurus
ENSG00000122126	OCRL	100	96.781	ENSCJAG00000002748	OCRL	89	96.781	Callithrix_jacchus
ENSG00000122126	OCRL	96	97.080	ENSCAFG00000018690	OCRL	100	95.828	Canis_familiaris
ENSG00000122126	OCRL	99	94.889	ENSCAFG00020001626	OCRL	100	94.889	Canis_lupus_dingo
ENSG00000122126	OCRL	100	94.673	ENSCHIG00000014041	OCRL	100	94.863	Capra_hircus
ENSG00000122126	OCRL	100	97.003	ENSTSYG00000005057	OCRL	100	97.003	Carlito_syrichta
ENSG00000122126	OCRL	100	95.893	ENSCPOG00000013608	OCRL	100	95.893	Cavia_porcellus
ENSG00000122126	OCRL	100	96.448	ENSCCAG00000010249	OCRL	100	96.448	Cebus_capucinus
ENSG00000122126	OCRL	100	99.445	ENSCATG00000037629	OCRL	89	99.445	Cercocebus_atys
ENSG00000122126	OCRL	99	96.509	ENSCLAG00000001724	OCRL	97	96.509	Chinchilla_lanigera
ENSG00000122126	OCRL	98	99.321	ENSCSAG00000008407	OCRL	100	99.321	Chlorocebus_sabaeus
ENSG00000122126	OCRL	95	84.191	ENSCPBG00000011986	OCRL	94	81.986	Chrysemys_picta_bellii
ENSG00000122126	OCRL	100	97.669	ENSCANG00000004777	OCRL	100	97.669	Colobus_angolensis_palliatus
ENSG00000122126	OCRL	100	94.007	ENSCGRG00001013791	Ocrl	100	94.007	Cricetulus_griseus_chok1gshd
ENSG00000122126	OCRL	96	92.343	ENSCGRG00000014789	Ocrl	99	92.343	Cricetulus_griseus_crigri
ENSG00000122126	OCRL	95	73.897	ENSCSEG00000002795	ocrl	99	58.830	Cynoglossus_semilaevis
ENSG00000122126	OCRL	64	71.608	ENSCVAG00000005512	ocrl	99	52.744	Cyprinodon_variegatus
ENSG00000122126	OCRL	95	72.794	ENSDARG00000078106	ocrl	99	59.772	Danio_rerio
ENSG00000122126	OCRL	97	94.934	ENSDNOG00000005035	OCRL	100	93.447	Dasypus_novemcinctus
ENSG00000122126	OCRL	97	94.493	ENSDORG00000004469	Ocrl	100	91.121	Dipodomys_ordii
ENSG00000122126	OCRL	100	94.118	ENSEASG00005007721	OCRL	100	94.118	Equus_asinus_asinus
ENSG00000122126	OCRL	100	96.448	ENSECAG00000010957	OCRL	100	96.448	Equus_caballus
ENSG00000122126	OCRL	100	90.929	ENSEEUG00000010786	OCRL	100	90.929	Erinaceus_europaeus
ENSG00000122126	OCRL	95	73.529	ENSELUG00000019958	ocrl	89	73.542	Esox_lucius
ENSG00000122126	OCRL	99	95.778	ENSFCAG00000023462	OCRL	100	95.778	Felis_catus
ENSG00000122126	OCRL	95	82.051	ENSFALG00000011786	OCRL	99	80.597	Ficedula_albicollis
ENSG00000122126	OCRL	99	96.059	ENSFDAG00000007671	OCRL	100	96.059	Fukomys_damarensis
ENSG00000122126	OCRL	94	72.963	ENSFHEG00000017566	ocrl	98	60.240	Fundulus_heteroclitus
ENSG00000122126	OCRL	94	72.862	ENSGMOG00000005366	ocrl	100	60.802	Gadus_morhua
ENSG00000122126	OCRL	95	86.081	ENSGALG00000003920	-	89	78.556	Gallus_gallus
ENSG00000122126	OCRL	94	70.741	ENSGAFG00000000256	ocrl	96	59.276	Gambusia_affinis
ENSG00000122126	OCRL	95	75.000	ENSGACG00000017367	ocrl	100	65.349	Gasterosteus_aculeatus
ENSG00000122126	OCRL	95	84.191	ENSGAGG00000018786	OCRL	90	79.861	Gopherus_agassizii
ENSG00000122126	OCRL	99	99.662	ENSGGOG00000000824	OCRL	100	99.662	Gorilla_gorilla
ENSG00000122126	OCRL	95	73.162	ENSHBUG00000016975	ocrl	99	61.704	Haplochromis_burtoni
ENSG00000122126	OCRL	100	96.226	ENSHGLG00000005330	OCRL	100	96.226	Heterocephalus_glaber_female
ENSG00000122126	OCRL	99	96.284	ENSHGLG00100003051	OCRL	100	96.372	Heterocephalus_glaber_male
ENSG00000122126	OCRL	95	73.162	ENSHCOG00000003673	ocrl	99	58.557	Hippocampus_comes
ENSG00000122126	OCRL	95	72.794	ENSIPUG00000018882	ocrl	99	59.401	Ictalurus_punctatus
ENSG00000122126	OCRL	100	96.781	ENSSTOG00000016123	OCRL	100	96.781	Ictidomys_tridecemlineatus
ENSG00000122126	OCRL	100	92.920	ENSJJAG00000023666	Ocrl	100	92.920	Jaculus_jaculus
ENSG00000122126	OCRL	94	71.747	ENSKMAG00000000622	ocrl	99	58.911	Kryptolebias_marmoratus
ENSG00000122126	OCRL	95	73.162	ENSLBEG00000028705	ocrl	97	58.414	Labrus_bergylta
ENSG00000122126	OCRL	95	74.632	ENSLOCG00000015266	ocrl	100	59.096	Lepisosteus_oculatus
ENSG00000122126	OCRL	100	94.469	ENSLAFG00000000900	OCRL	100	94.469	Loxodonta_africana
ENSG00000122126	OCRL	100	99.445	ENSMFAG00000033457	OCRL	100	99.445	Macaca_fascicularis
ENSG00000122126	OCRL	100	99.223	ENSMMUG00000008825	OCRL	100	99.223	Macaca_mulatta
ENSG00000122126	OCRL	100	99.001	ENSMNEG00000039517	OCRL	100	99.434	Macaca_nemestrina
ENSG00000122126	OCRL	99	99.437	ENSMLEG00000033019	OCRL	100	99.437	Mandrillus_leucophaeus
ENSG00000122126	OCRL	95	68.750	ENSMAMG00000020233	ocrl	99	57.519	Mastacembelus_armatus
ENSG00000122126	OCRL	95	73.162	ENSMZEG00005007494	ocrl	99	61.070	Maylandia_zebra
ENSG00000122126	OCRL	95	86.765	ENSMGAG00000002018	OCRL	100	79.769	Meleagris_gallopavo
ENSG00000122126	OCRL	96	95.255	ENSMAUG00000011733	Ocrl	100	94.724	Mesocricetus_auratus
ENSG00000122126	OCRL	100	97.424	ENSMICG00000015790	OCRL	100	97.424	Microcebus_murinus
ENSG00000122126	OCRL	100	93.103	ENSMOCG00000010531	Ocrl	100	93.103	Microtus_ochrogaster
ENSG00000122126	OCRL	95	73.529	ENSMMOG00000004215	ocrl	98	61.438	Mola_mola
ENSG00000122126	OCRL	95	73.897	ENSMODG00000025043	-	99	74.925	Monodelphis_domestica
ENSG00000122126	OCRL	95	83.456	ENSMODG00000013199	-	99	78.611	Monodelphis_domestica
ENSG00000122126	OCRL	95	72.794	ENSMALG00000008458	ocrl	99	61.322	Monopterus_albus
ENSG00000122126	OCRL	100	91.787	MGP_CAROLIEiJ_G0033035	Ocrl	100	91.787	Mus_caroli
ENSG00000122126	OCRL	100	91.454	ENSMUSG00000001173	Ocrl	100	91.454	Mus_musculus
ENSG00000122126	OCRL	100	92.786	MGP_PahariEiJ_G0031580	Ocrl	100	92.786	Mus_pahari
ENSG00000122126	OCRL	100	91.565	MGP_SPRETEiJ_G0034193	Ocrl	100	91.565	Mus_spretus
ENSG00000122126	OCRL	99	95.444	ENSMPUG00000017424	OCRL	100	95.444	Mustela_putorius_furo
ENSG00000122126	OCRL	100	91.454	ENSMLUG00000015997	OCRL	100	91.454	Myotis_lucifugus
ENSG00000122126	OCRL	100	95.073	ENSNGAG00000017805	Ocrl	100	95.073	Nannospalax_galili
ENSG00000122126	OCRL	95	73.162	ENSNBRG00000021219	ocrl	99	61.530	Neolamprologus_brichardi
ENSG00000122126	OCRL	100	96.997	ENSNLEG00000015200	OCRL	100	96.997	Nomascus_leucogenys
ENSG00000122126	OCRL	95	76.471	ENSMEUG00000002996	-	99	70.201	Notamacropus_eugenii
ENSG00000122126	OCRL	99	76.543	ENSMEUG00000013967	-	100	76.543	Notamacropus_eugenii
ENSG00000122126	OCRL	68	94.872	ENSOPRG00000014159	OCRL	71	94.872	Ochotona_princeps
ENSG00000122126	OCRL	100	95.857	ENSODEG00000012324	OCRL	100	95.857	Octodon_degus
ENSG00000122126	OCRL	92	71.863	ENSONIG00000002581	ocrl	99	59.040	Oreochromis_niloticus
ENSG00000122126	OCRL	95	87.546	ENSOANG00000012031	-	99	85.363	Ornithorhynchus_anatinus
ENSG00000122126	OCRL	100	95.450	ENSOCUG00000016167	OCRL	100	95.450	Oryctolagus_cuniculus
ENSG00000122126	OCRL	95	68.015	ENSORLG00000001194	ocrl	99	57.203	Oryzias_latipes
ENSG00000122126	OCRL	95	67.647	ENSORLG00020022164	ocrl	99	57.576	Oryzias_latipes_hni
ENSG00000122126	OCRL	95	68.382	ENSORLG00015012633	ocrl	99	66.802	Oryzias_latipes_hsok
ENSG00000122126	OCRL	95	67.279	ENSOMEG00000015169	ocrl	93	57.722	Oryzias_melastigma
ENSG00000122126	OCRL	100	94.696	ENSOGAG00000004402	OCRL	100	94.696	Otolemur_garnettii
ENSG00000122126	OCRL	100	94.358	ENSOARG00000014769	OCRL	100	94.358	Ovis_aries
ENSG00000122126	OCRL	100	97.545	ENSPPAG00000022524	OCRL	100	97.545	Pan_paniscus
ENSG00000122126	OCRL	99	95.778	ENSPPRG00000009705	OCRL	100	95.778	Panthera_pardus
ENSG00000122126	OCRL	98	95.716	ENSPTIG00000007178	OCRL	99	95.716	Panthera_tigris_altaica
ENSG00000122126	OCRL	100	99.889	ENSPTRG00000022257	OCRL	100	99.889	Pan_troglodytes
ENSG00000122126	OCRL	100	99.445	ENSPANG00000026248	OCRL	100	99.445	Papio_anubis
ENSG00000122126	OCRL	95	69.118	ENSPKIG00000021691	ocrl	98	56.618	Paramormyrops_kingsleyae
ENSG00000122126	OCRL	95	76.103	ENSPKIG00000013523	ocrl	94	68.262	Paramormyrops_kingsleyae
ENSG00000122126	OCRL	95	83.824	ENSPSIG00000004274	OCRL	99	77.451	Pelodiscus_sinensis
ENSG00000122126	OCRL	100	95.117	ENSPEMG00000012326	Ocrl	100	95.117	Peromyscus_maniculatus_bairdii
ENSG00000122126	OCRL	99	79.842	ENSPCIG00000015412	-	99	79.842	Phascolarctos_cinereus
ENSG00000122126	OCRL	94	70.741	ENSPFOG00000017105	ocrl	99	60.556	Poecilia_formosa
ENSG00000122126	OCRL	94	71.481	ENSPLAG00000020412	ocrl	99	59.584	Poecilia_latipinna
ENSG00000122126	OCRL	94	70.741	ENSPMEG00000024157	ocrl	99	58.043	Poecilia_mexicana
ENSG00000122126	OCRL	94	70.741	ENSPREG00000011774	ocrl	99	59.344	Poecilia_reticulata
ENSG00000122126	OCRL	100	94.451	ENSPPYG00000020704	OCRL	100	94.451	Pongo_abelii
ENSG00000122126	OCRL	96	94.193	ENSPCAG00000009820	OCRL	100	94.193	Procavia_capensis
ENSG00000122126	OCRL	100	95.745	ENSPCOG00000017071	OCRL	100	95.745	Propithecus_coquereli
ENSG00000122126	OCRL	95	72.426	ENSPNYG00000010286	ocrl	99	60.749	Pundamilia_nyererei
ENSG00000122126	OCRL	95	74.632	ENSPNAG00000020943	ocrl	99	60.892	Pygocentrus_nattereri
ENSG00000122126	OCRL	100	93.473	ENSRNOG00000003875	Ocrl	100	93.473	Rattus_norvegicus
ENSG00000122126	OCRL	100	97.114	ENSRBIG00000041702	OCRL	100	97.114	Rhinopithecus_bieti
ENSG00000122126	OCRL	98	99.434	ENSRROG00000042261	OCRL	100	99.434	Rhinopithecus_roxellana
ENSG00000122126	OCRL	98	96.946	ENSSBOG00000032679	OCRL	100	96.946	Saimiri_boliviensis_boliviensis
ENSG00000122126	OCRL	95	83.088	ENSSHAG00000014095	-	100	79.330	Sarcophilus_harrisii
ENSG00000122126	OCRL	95	75.368	ENSSHAG00000014363	-	100	70.285	Sarcophilus_harrisii
ENSG00000122126	OCRL	95	73.529	ENSSFOG00015010512	ocrl	100	69.746	Scleropages_formosus
ENSG00000122126	OCRL	95	70.221	ENSSFOG00015005935	ocrl	99	56.459	Scleropages_formosus
ENSG00000122126	OCRL	95	74.265	ENSSMAG00000013174	ocrl	99	62.432	Scophthalmus_maximus
ENSG00000122126	OCRL	95	74.632	ENSSDUG00000005993	ocrl	99	61.987	Seriola_dumerili
ENSG00000122126	OCRL	95	74.632	ENSSLDG00000002619	ocrl	99	61.580	Seriola_lalandi_dorsalis
ENSG00000122126	OCRL	96	91.007	ENSSARG00000004144	OCRL	100	88.608	Sorex_araneus
ENSG00000122126	OCRL	95	85.294	ENSSPUG00000018129	OCRL	99	79.438	Sphenodon_punctatus
ENSG00000122126	OCRL	95	76.103	ENSSPAG00000009581	ocrl	98	58.953	Stegastes_partitus
ENSG00000122126	OCRL	100	94.562	ENSSSCG00000012650	OCRL	100	94.570	Sus_scrofa
ENSG00000122126	OCRL	95	82.051	ENSTGUG00000004995	OCRL	99	76.497	Taeniopygia_guttata
ENSG00000122126	OCRL	95	73.897	ENSTRUG00000008986	ocrl	99	59.243	Takifugu_rubripes
ENSG00000122126	OCRL	95	74.265	ENSTNIG00000015772	ocrl	99	64.633	Tetraodon_nigroviridis
ENSG00000122126	OCRL	96	94.891	ENSTBEG00000006194	OCRL	89	95.152	Tupaia_belangeri
ENSG00000122126	OCRL	100	94.340	ENSTTRG00000006169	OCRL	100	94.340	Tursiops_truncatus
ENSG00000122126	OCRL	91	96.825	ENSUAMG00000020206	-	95	94.518	Ursus_americanus
ENSG00000122126	OCRL	98	95.357	ENSUMAG00000004516	OCRL	100	95.357	Ursus_maritimus
ENSG00000122126	OCRL	96	89.416	ENSVPAG00000010495	OCRL	92	93.590	Vicugna_pacos
ENSG00000122126	OCRL	96	97.080	ENSVVUG00000008897	OCRL	100	93.444	Vulpes_vulpes
ENSG00000122126	OCRL	95	78.309	ENSXETG00000032071	OCRL	97	73.836	Xenopus_tropicalis
ENSG00000122126	OCRL	94	71.111	ENSXCOG00000016529	ocrl	97	57.688	Xiphophorus_couchianus
ENSG00000122126	OCRL	94	71.481	ENSXMAG00000013582	ocrl	99	59.037	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001701	in utero embryonic development	-	IEA	Process
GO:0001750	photoreceptor outer segment	22543976.	IDA	Component
GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	21873635.	IBA	Function
GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	-	TAS	Function
GO:0005096	GTPase activator activity	12915445.	IDA	Function
GO:0005515	protein binding	12915445.16902405.19536138.21233288.21378754.22543976.25107275.25869668.26496610.26824392.	IPI	Function
GO:0005634	nucleus	12915445.	IDA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	12915445.	IDA	Component
GO:0005769	early endosome	21233288.25869668.	IDA	Component
GO:0005795	Golgi stack	1840503.	TAS	Component
GO:0005798	Golgi-associated vesicle	1840503.	TAS	Component
GO:0005802	trans-Golgi network	12915445.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005886	plasma membrane	12915445.	IDA	Component
GO:0005905	clathrin-coated pit	-	IEA	Component
GO:0006629	lipid metabolic process	1321346.	NAS	Process
GO:0006661	phosphatidylinositol biosynthetic process	-	TAS	Process
GO:0007165	signal transduction	-	IEA	Process
GO:0016020	membrane	21873635.	IBA	Component
GO:0030136	clathrin-coated vesicle	21233288.25869668.	IDA	Component
GO:0030670	phagocytic vesicle membrane	-	IEA	Component
GO:0031901	early endosome membrane	-	IEA	Component
GO:0043087	regulation of GTPase activity	12915445.	IDA	Process
GO:0043547	positive regulation of GTPase activity	-	IEA	Process
GO:0043647	inositol phosphate metabolic process	-	TAS	Process
GO:0046855	inositol phosphate dephosphorylation	21873635.	IBA	Process
GO:0046856	phosphatidylinositol dephosphorylation	21873635.	IBA	Process
GO:0048365	Rac GTPase binding	12915445.	IPI	Function
GO:0051056	regulation of small GTPase mediated signal transduction	-	TAS	Process
GO:0052745	inositol phosphate phosphatase activity	25869668.	IDA	Function
GO:0052745	inositol phosphate phosphatase activity	1321346.	NAS	Function
GO:0060271	cilium assembly	22228094.22543976.	IMP	Process
GO:0061024	membrane organization	-	TAS	Process