EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000122140 (Gene tree)
Gene ID: 51116
Gene Symbol: MRPS2
Alias: CGI-91
Full Name: mitochondrial ribosomal protein S2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 4,690 bases
Position: chr9:135,499,984-135,504,673
Accession: 14495
RBP type: canonical RBP
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S2 family. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000241600	Ribosomal_S2	PF00318.20	7.9e-42	1	2
ENSP00000241600	Ribosomal_S2	PF00318.20	7.9e-42	2	2
ENSP00000360850	Ribosomal_S2	PF00318.20	7.9e-42	1	2
ENSP00000360850	Ribosomal_S2	PF00318.20	7.9e-42	2	2
ENSP00000400082	Ribosomal_S2	PF00318.20	5.6e-41	1	2
ENSP00000400082	Ribosomal_S2	PF00318.20	5.6e-41	2	2

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000485333	MRPS2-207	881	-	-	- (aa)	-	-
ENST00000453385	MRPS2-203	810	-	ENSP00000400082	270 (aa)	-	Q5T8A0
ENST00000371785	MRPS2-202	1640	XM_006717136	ENSP00000360850	296 (aa)	XP_006717199	Q9Y399
ENST00000488610	MRPS2-208	928	-	-	- (aa)	-	-
ENST00000241600	MRPS2-201	1510	-	ENSP00000241600	296 (aa)	-	Q9Y399
ENST00000472946	MRPS2-206	495	-	-	- (aa)	-	-
ENST00000462948	MRPS2-204	551	-	-	- (aa)	-	-
ENST00000472852	MRPS2-205	854	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000122140's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03010	Ribosome	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000122140's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000122140	MRPS2	89	63.673	ENSAPOG00000023961	mrps2	98	61.624	Acanthochromis_polyacanthus
ENSG00000122140	MRPS2	86	80.620	ENSAMEG00000006236	MRPS2	90	80.620	Ailuropoda_melanoleuca
ENSG00000122140	MRPS2	73	73.096	ENSACIG00000002684	mrps2	91	69.333	Amphilophus_citrinellus
ENSG00000122140	MRPS2	94	58.273	ENSAOCG00000007626	mrps2	65	63.563	Amphiprion_ocellaris
ENSG00000122140	MRPS2	72	72.308	ENSAPEG00000023312	mrps2	75	62.891	Amphiprion_percula
ENSG00000122140	MRPS2	73	70.202	ENSATEG00000011658	mrps2	81	68.203	Anabas_testudineus
ENSG00000122140	MRPS2	72	78.462	ENSAPLG00000004062	MRPS2	100	74.429	Anas_platyrhynchos
ENSG00000122140	MRPS2	100	87.162	ENSANAG00000031323	MRPS2	100	87.162	Aotus_nancymaae
ENSG00000122140	MRPS2	73	73.232	ENSACLG00000027610	mrps2	79	70.507	Astatotilapia_calliptera
ENSG00000122140	MRPS2	75	67.822	ENSAMXG00000040826	mrps2	82	66.514	Astyanax_mexicanus
ENSG00000122140	MRPS2	93	77.455	ENSBTAG00000005688	MRPS2	99	73.597	Bos_taurus
ENSG00000122140	MRPS2	72	42.268	WBGene00020718	mrps-2	78	42.233	Caenorhabditis_elegans
ENSG00000122140	MRPS2	100	88.514	ENSCJAG00000010436	MRPS2	100	88.514	Callithrix_jacchus
ENSG00000122140	MRPS2	91	75.556	ENSCAFG00000019862	MRPS2	80	75.556	Canis_familiaris
ENSG00000122140	MRPS2	81	78.995	ENSCHIG00000020569	MRPS2	96	69.565	Capra_hircus
ENSG00000122140	MRPS2	96	64.085	ENSTSYG00000009349	MRPS2	96	64.085	Carlito_syrichta
ENSG00000122140	MRPS2	74	87.000	ENSCAPG00000000630	MRPS2	99	82.684	Cavia_aperea
ENSG00000122140	MRPS2	86	80.603	ENSCPOG00000035320	MRPS2	99	74.216	Cavia_porcellus
ENSG00000122140	MRPS2	99	89.078	ENSCCAG00000031563	MRPS2	97	89.078	Cebus_capucinus
ENSG00000122140	MRPS2	100	86.557	ENSCATG00000041977	MRPS2	100	86.557	Cercocebus_atys
ENSG00000122140	MRPS2	95	75.000	ENSCLAG00000005994	MRPS2	99	75.000	Chinchilla_lanigera
ENSG00000122140	MRPS2	97	89.153	ENSCSAG00000015621	MRPS2	100	89.153	Chlorocebus_sabaeus
ENSG00000122140	MRPS2	93	57.971	ENSCHOG00000005552	MRPS2	96	57.971	Choloepus_hoffmanni
ENSG00000122140	MRPS2	84	70.175	ENSCPBG00000012281	MRPS2	96	69.200	Chrysemys_picta_bellii
ENSG00000122140	MRPS2	73	51.531	ENSCING00000008713	-	73	51.471	Ciona_intestinalis
ENSG00000122140	MRPS2	98	91.288	ENSCANG00000032278	MRPS2	93	91.135	Colobus_angolensis_palliatus
ENSG00000122140	MRPS2	99	72.203	ENSCGRG00001024411	Mrps2	99	72.203	Cricetulus_griseus_chok1gshd
ENSG00000122140	MRPS2	98	72.759	ENSCGRG00000016434	Mrps2	99	72.759	Cricetulus_griseus_crigri
ENSG00000122140	MRPS2	74	71.000	ENSCSEG00000014820	mrps2	88	69.406	Cynoglossus_semilaevis
ENSG00000122140	MRPS2	57	73.203	ENSCSEG00000007195	mrps2	96	70.930	Cynoglossus_semilaevis
ENSG00000122140	MRPS2	80	62.869	ENSCVAG00000014488	mrps2	87	62.869	Cyprinodon_variegatus
ENSG00000122140	MRPS2	74	70.500	ENSDARG00000103198	mrps2	89	66.239	Danio_rerio
ENSG00000122140	MRPS2	99	73.179	ENSDNOG00000041081	MRPS2	93	73.179	Dasypus_novemcinctus
ENSG00000122140	MRPS2	85	83.004	ENSDORG00000009636	Mrps2	96	83.004	Dipodomys_ordii
ENSG00000122140	MRPS2	70	62.632	FBgn0031639	mRpS2	77	61.275	Drosophila_melanogaster
ENSG00000122140	MRPS2	76	80.583	ENSETEG00000002673	MRPS2	97	80.583	Echinops_telfairi
ENSG00000122140	MRPS2	75	52.941	ENSEBUG00000007583	mrps2	76	51.598	Eptatretus_burgeri
ENSG00000122140	MRPS2	95	78.014	ENSEASG00005010711	MRPS2	97	78.014	Equus_asinus_asinus
ENSG00000122140	MRPS2	95	78.014	ENSECAG00000032143	MRPS2	97	78.014	Equus_caballus
ENSG00000122140	MRPS2	75	72.414	ENSELUG00000003223	mrps2	83	71.905	Esox_lucius
ENSG00000122140	MRPS2	86	84.416	ENSFCAG00000000137	MRPS2	67	82.239	Felis_catus
ENSG00000122140	MRPS2	73	76.768	ENSFALG00000001692	MRPS2	96	73.853	Ficedula_albicollis
ENSG00000122140	MRPS2	74	85.427	ENSFDAG00000007080	MRPS2	91	81.385	Fukomys_damarensis
ENSG00000122140	MRPS2	61	67.956	ENSFHEG00000001911	mrps2	74	67.956	Fundulus_heteroclitus
ENSG00000122140	MRPS2	72	74.359	ENSGMOG00000018790	mrps2	98	72.170	Gadus_morhua
ENSG00000122140	MRPS2	57	77.778	ENSGALG00000026303	MRPS2	99	69.149	Gallus_gallus
ENSG00000122140	MRPS2	73	66.667	ENSGAFG00000014147	mrps2	82	65.741	Gambusia_affinis
ENSG00000122140	MRPS2	72	71.649	ENSGACG00000015913	mrps2	82	69.340	Gasterosteus_aculeatus
ENSG00000122140	MRPS2	87	71.368	ENSGAGG00000021844	MRPS2	94	69.767	Gopherus_agassizii
ENSG00000122140	MRPS2	100	96.959	ENSGGOG00000013400	MRPS2	95	96.959	Gorilla_gorilla
ENSG00000122140	MRPS2	92	60.584	ENSHBUG00000010171	mrps2	58	60.584	Haplochromis_burtoni
ENSG00000122140	MRPS2	75	82.178	ENSHGLG00000011363	MRPS2	90	79.221	Heterocephalus_glaber_female
ENSG00000122140	MRPS2	75	82.178	ENSHGLG00100008584	MRPS2	90	79.221	Heterocephalus_glaber_male
ENSG00000122140	MRPS2	83	62.348	ENSHCOG00000005980	mrps2	94	62.348	Hippocampus_comes
ENSG00000122140	MRPS2	81	63.303	ENSIPUG00000009591	mrps2	88	63.362	Ictalurus_punctatus
ENSG00000122140	MRPS2	97	72.664	ENSSTOG00000002273	MRPS2	98	72.664	Ictidomys_tridecemlineatus
ENSG00000122140	MRPS2	93	78.182	ENSJJAG00000004108	Mrps2	92	78.182	Jaculus_jaculus
ENSG00000122140	MRPS2	83	65.022	ENSKMAG00000012557	mrps2	94	62.753	Kryptolebias_marmoratus
ENSG00000122140	MRPS2	79	65.421	ENSLBEG00000025218	mrps2	82	64.378	Labrus_bergylta
ENSG00000122140	MRPS2	79	65.888	ENSLBEG00000008884	MRPS2	82	64.807	Labrus_bergylta
ENSG00000122140	MRPS2	79	70.755	ENSLACG00000018836	MRPS2	84	69.658	Latimeria_chalumnae
ENSG00000122140	MRPS2	86	66.667	ENSLOCG00000003705	mrps2	94	64.202	Lepisosteus_oculatus
ENSG00000122140	MRPS2	90	81.070	ENSLAFG00000023206	MRPS2	94	79.182	Loxodonta_africana
ENSG00000122140	MRPS2	100	89.527	ENSMFAG00000001860	MRPS2	100	89.527	Macaca_fascicularis
ENSG00000122140	MRPS2	100	89.527	ENSMMUG00000021597	MRPS2	100	89.527	Macaca_mulatta
ENSG00000122140	MRPS2	100	86.885	ENSMNEG00000021216	MRPS2	100	86.885	Macaca_nemestrina
ENSG00000122140	MRPS2	95	90.391	ENSMLEG00000035518	MRPS2	100	90.391	Mandrillus_leucophaeus
ENSG00000122140	MRPS2	89	62.241	ENSMAMG00000019225	mrps2	99	61.538	Mastacembelus_armatus
ENSG00000122140	MRPS2	81	66.109	ENSMZEG00005004066	mrps2	81	70.507	Maylandia_zebra
ENSG00000122140	MRPS2	73	77.273	ENSMGAG00000007390	MRPS2	98	73.874	Meleagris_gallopavo
ENSG00000122140	MRPS2	99	72.449	ENSMAUG00000011150	Mrps2	99	72.449	Mesocricetus_auratus
ENSG00000122140	MRPS2	97	83.916	ENSMICG00000030645	MRPS2	97	83.916	Microcebus_murinus
ENSG00000122140	MRPS2	99	61.017	ENSMOCG00000006116	-	99	61.017	Microtus_ochrogaster
ENSG00000122140	MRPS2	99	71.622	ENSMOCG00000006783	-	99	71.622	Microtus_ochrogaster
ENSG00000122140	MRPS2	99	71.622	ENSMOCG00000018447	-	99	71.622	Microtus_ochrogaster
ENSG00000122140	MRPS2	79	65.957	ENSMMOG00000004705	mrps2	87	65.957	Mola_mola
ENSG00000122140	MRPS2	96	67.368	ENSMODG00000017608	-	98	67.368	Monodelphis_domestica
ENSG00000122140	MRPS2	86	65.678	ENSMALG00000002659	mrps2	93	64.173	Monopterus_albus
ENSG00000122140	MRPS2	99	71.525	MGP_CAROLIEiJ_G0023350	Mrps2	99	71.525	Mus_caroli
ENSG00000122140	MRPS2	99	71.525	ENSMUSG00000035772	Mrps2	99	71.525	Mus_musculus
ENSG00000122140	MRPS2	99	71.864	MGP_PahariEiJ_G0024807	Mrps2	99	71.864	Mus_pahari
ENSG00000122140	MRPS2	99	71.186	MGP_SPRETEiJ_G0024267	Mrps2	99	71.186	Mus_spretus
ENSG00000122140	MRPS2	93	77.698	ENSMPUG00000012038	MRPS2	96	77.698	Mustela_putorius_furo
ENSG00000122140	MRPS2	78	85.714	ENSMLUG00000013877	MRPS2	95	85.714	Myotis_lucifugus
ENSG00000122140	MRPS2	97	76.573	ENSNGAG00000012946	Mrps2	100	76.573	Nannospalax_galili
ENSG00000122140	MRPS2	83	66.667	ENSNBRG00000008658	mrps2	81	69.863	Neolamprologus_brichardi
ENSG00000122140	MRPS2	100	93.581	ENSNLEG00000008804	MRPS2	100	93.581	Nomascus_leucogenys
ENSG00000122140	MRPS2	87	75.745	ENSMEUG00000005181	MRPS2	97	72.519	Notamacropus_eugenii
ENSG00000122140	MRPS2	75	68.018	ENSOPRG00000012165	-	97	68.018	Ochotona_princeps
ENSG00000122140	MRPS2	95	76.786	ENSODEG00000015658	MRPS2	96	76.786	Octodon_degus
ENSG00000122140	MRPS2	74	73.000	ENSONIG00000011240	mrps2	84	70.776	Oreochromis_niloticus
ENSG00000122140	MRPS2	79	45.992	ENSOANG00000020558	-	100	45.992	Ornithorhynchus_anatinus
ENSG00000122140	MRPS2	79	69.811	ENSORLG00000003640	mrps2	87	68.240	Oryzias_latipes
ENSG00000122140	MRPS2	79	69.811	ENSORLG00020010352	mrps2	87	68.240	Oryzias_latipes_hni
ENSG00000122140	MRPS2	79	69.811	ENSORLG00015017409	mrps2	87	68.240	Oryzias_latipes_hsok
ENSG00000122140	MRPS2	72	72.308	ENSOMEG00000013207	mrps2	80	71.028	Oryzias_melastigma
ENSG00000122140	MRPS2	94	82.374	ENSOGAG00000000550	MRPS2	100	82.374	Otolemur_garnettii
ENSG00000122140	MRPS2	100	98.649	ENSPPAG00000029054	MRPS2	93	98.649	Pan_paniscus
ENSG00000122140	MRPS2	96	79.021	ENSPPRG00000000729	MRPS2	99	79.021	Panthera_pardus
ENSG00000122140	MRPS2	74	88.442	ENSPTIG00000010932	MRPS2	85	87.081	Panthera_tigris_altaica
ENSG00000122140	MRPS2	100	98.311	ENSPTRG00000043161	-	93	98.311	Pan_troglodytes
ENSG00000122140	MRPS2	100	98.311	ENSPTRG00000021537	MRPS2	93	98.311	Pan_troglodytes
ENSG00000122140	MRPS2	75	90.984	ENSPANG00000026112	MRPS2	75	90.984	Papio_anubis
ENSG00000122140	MRPS2	78	65.403	ENSPKIG00000004472	mrps2	81	65.778	Paramormyrops_kingsleyae
ENSG00000122140	MRPS2	87	71.368	ENSPSIG00000009613	MRPS2	95	70.000	Pelodiscus_sinensis
ENSG00000122140	MRPS2	83	64.574	ENSPMGG00000016732	mrps2	79	63.223	Periophthalmus_magnuspinnatus
ENSG00000122140	MRPS2	73	60.606	ENSPMAG00000004348	mrps2	96	59.722	Petromyzon_marinus
ENSG00000122140	MRPS2	87	75.214	ENSPCIG00000019526	MRPS2	77	68.041	Phascolarctos_cinereus
ENSG00000122140	MRPS2	74	67.337	ENSPFOG00000014903	mrps2	99	65.471	Poecilia_formosa
ENSG00000122140	MRPS2	79	65.421	ENSPLAG00000004859	mrps2	88	64.135	Poecilia_latipinna
ENSG00000122140	MRPS2	81	62.273	ENSPMEG00000022522	mrps2	90	61.317	Poecilia_mexicana
ENSG00000122140	MRPS2	79	65.421	ENSPREG00000021519	mrps2	87	64.935	Poecilia_reticulata
ENSG00000122140	MRPS2	100	68.581	ENSPPYG00000019758	-	100	68.581	Pongo_abelii
ENSG00000122140	MRPS2	99	82.935	ENSPCOG00000021399	MRPS2	100	82.935	Propithecus_coquereli
ENSG00000122140	MRPS2	74	78.862	ENSPVAG00000009539	MRPS2	74	78.862	Pteropus_vampyrus
ENSG00000122140	MRPS2	73	73.232	ENSPNYG00000002624	mrps2	81	70.507	Pundamilia_nyererei
ENSG00000122140	MRPS2	73	71.939	ENSPNAG00000027757	mrps2	87	66.957	Pygocentrus_nattereri
ENSG00000122140	MRPS2	99	70.508	ENSRNOG00000010164	Mrps2	99	70.508	Rattus_norvegicus
ENSG00000122140	MRPS2	100	88.525	ENSRBIG00000042014	MRPS2	100	88.525	Rhinopithecus_bieti
ENSG00000122140	MRPS2	100	90.878	ENSRROG00000029542	MRPS2	100	90.878	Rhinopithecus_roxellana
ENSG00000122140	MRPS2	66	34.146	YHL004W	-	55	32.883	Saccharomyces_cerevisiae
ENSG00000122140	MRPS2	95	88.968	ENSSBOG00000024746	MRPS2	98	88.968	Saimiri_boliviensis_boliviensis
ENSG00000122140	MRPS2	89	70.539	ENSSHAG00000018437	MRPS2	98	69.202	Sarcophilus_harrisii
ENSG00000122140	MRPS2	79	67.925	ENSSFOG00015020360	mrps2	85	66.094	Scleropages_formosus
ENSG00000122140	MRPS2	78	68.396	ENSSMAG00000010885	mrps2	86	65.823	Scophthalmus_maximus
ENSG00000122140	MRPS2	73	70.707	ENSSDUG00000007294	mrps2	83	67.713	Seriola_dumerili
ENSG00000122140	MRPS2	73	70.707	ENSSLDG00000015489	mrps2	84	69.626	Seriola_lalandi_dorsalis
ENSG00000122140	MRPS2	91	65.074	ENSSPUG00000017642	MRPS2	98	65.074	Sphenodon_punctatus
ENSG00000122140	MRPS2	74	70.647	ENSSPAG00000010974	mrps2	59	68.304	Stegastes_partitus
ENSG00000122140	MRPS2	97	77.003	ENSSSCG00000005759	MRPS2	99	77.003	Sus_scrofa
ENSG00000122140	MRPS2	73	77.551	ENSTGUG00000006064	MRPS2	100	75.463	Taeniopygia_guttata
ENSG00000122140	MRPS2	74	69.500	ENSTRUG00000018568	mrps2	81	67.742	Takifugu_rubripes
ENSG00000122140	MRPS2	82	63.786	ENSTNIG00000013444	mrps2	90	63.786	Tetraodon_nigroviridis
ENSG00000122140	MRPS2	98	78.276	ENSTTRG00000000014	MRPS2	98	78.276	Tursiops_truncatus
ENSG00000122140	MRPS2	97	67.550	ENSUAMG00000015488	MRPS2	98	67.550	Ursus_americanus
ENSG00000122140	MRPS2	78	82.051	ENSVVUG00000027559	MRPS2	93	82.051	Vulpes_vulpes
ENSG00000122140	MRPS2	80	71.296	ENSXETG00000022329	mrps2	85	69.748	Xenopus_tropicalis
ENSG00000122140	MRPS2	73	69.192	ENSXCOG00000000756	mrps2	75	68.571	Xiphophorus_couchianus
ENSG00000122140	MRPS2	73	69.697	ENSXMAG00000018132	mrps2	83	69.048	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003735	structural constituent of ribosome	21873635.	IBA	Function
GO:0003735	structural constituent of ribosome	11402041.	ISS	Function
GO:0005739	mitochondrion	-	IDA	Component
GO:0005743	mitochondrial inner membrane	-	TAS	Component
GO:0005763	mitochondrial small ribosomal subunit	21873635.	IBA	Component
GO:0005763	mitochondrial small ribosomal subunit	25838379.	IDA	Component
GO:0005763	mitochondrial small ribosomal subunit	11402041.	ISS	Component
GO:0032543	mitochondrial translation	11402041.	ISS	Process
GO:0061668	mitochondrial ribosome assembly	29576219.	IMP	Process
GO:0070125	mitochondrial translational elongation	-	TAS	Process
GO:0070126	mitochondrial translational termination	-	TAS	Process