EuRBPDB

Description

Ensembl ID: ENSG00000122218 (Gene tree)
Gene ID: 1314
Gene Symbol: COPA
Alias: HEP-COP
Full Name: coatomer protein complex subunit alpha
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 54,978 bases
Position: chr1:160,288,587-160,343,564
Accession: 2230
RBP type: non-canonical RBP
Summary: In eukaryotic cells, protein transport between the endoplasmic reticulum and Golgi compartments is mediated in part by non-clathrin-coated vesicular coat proteins (COPs). Seven coat proteins have been identified, and they represent subunits of a complex known as coatomer. The subunits are designated alpha-COP, beta-COP, beta-prime-COP, gamma-COP, delta-COP, epsilon-COP, and zeta-COP. The alpha-COP, encoded by COPA, shares high sequence similarity with RET1P, the alpha subunit of the coatomer complex in yeast. Also, the N-terminal 25 amino acids of alpha-COP encode the bioactive peptide, xenin, which stimulates exocrine pancreatic secretion and may act as a gastrointestinal hormone. Alternative splicing results in multiple splice forms encoding distinct isoforms. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
10744017	An unusual structure formed by antisense-target RNA binding involves an extended kissing complex with a four-way junction and a side-by-side helical alignment.	RNA	2000 Mar	Kolb FA	-
11502000	Real time kinetic studies of the interaction between folded antisense and target RNAs using surface plasmon resonance.	J Mol Biol	2001 Jul 27	Nordgren S	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000545266	COPA-206	574	-	-	- (aa)	-	-
ENST00000545284	COPA-207	879	-	-	- (aa)	-	-
ENST00000649963	COPA-219	5175	-	ENSP00000498129	78 (aa)	-	UPI00024D1160
ENST00000649676	COPA-217	4031	-	ENSP00000497257	1024 (aa)	-	-
ENST00000241704	COPA-201	4789	-	ENSP00000241704	1224 (aa)	-	P53621
ENST00000648805	COPA-215	4504	-	ENSP00000497433	455 (aa)	-	-
ENST00000647683	COPA-208	4239	-	ENSP00000497495	1204 (aa)	-	-
ENST00000368069	COPA-202	4664	-	ENSP00000357048	1233 (aa)	-	P53621
ENST00000647693	COPA-209	5462	-	-	- (aa)	-	-
ENST00000648280	COPA-212	2160	-	ENSP00000497811	452 (aa)	-	-
ENST00000481040	COPA-203	578	-	-	- (aa)	-	-
ENST00000648632	COPA-214	539	-	-	- (aa)	-	-
ENST00000649231	COPA-216	3969	-	ENSP00000498061	609 (aa)	-	-
ENST00000647899	COPA-211	2046	-	ENSP00000498078	682 (aa)	-	-
ENST00000541366	COPA-205	616	-	-	- (aa)	-	-
ENST00000648501	COPA-213	3524	-	ENSP00000498118	121 (aa)	-	-
ENST00000647799	COPA-210	4454	-	ENSP00000497970	161 (aa)	-	-
ENST00000650154	COPA-220	4458	-	ENSP00000497094	134 (aa)	-	-
ENST00000649787	COPA-218	4567	-	ENSP00000497231	1204 (aa)	-	-
ENST00000481522	COPA-204	578	-	-	- (aa)	-	-

Gene Model

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000122218	COPA	100	98.459	ENSMUSG00000026553	Copa	100	98.459	Mus_musculus
ENSG00000122218	COPA	98	54.286	YDL145C	COP1	99	44.075	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000139	Golgi membrane	-	TAS	Component
GO:0005179	hormone activity	-	IEA	Function
GO:0005198	structural molecule activity	-	IEA	Function
GO:0005615	extracellular space	1429581.	IDA	Component
GO:0005737	cytoplasm	9115636.	IDA	Component
GO:0005789	endoplasmic reticulum membrane	-	TAS	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006886	intracellular protein transport	21873635.	IBA	Process
GO:0006888	ER to Golgi vesicle-mediated transport	21873635.	IBA	Process
GO:0006888	ER to Golgi vesicle-mediated transport	-	TAS	Process
GO:0006890	retrograde vesicle-mediated transport, Golgi to ER	21873635.	IBA	Process
GO:0006890	retrograde vesicle-mediated transport, Golgi to ER	-	TAS	Process
GO:0006891	intra-Golgi vesicle-mediated transport	21873635.	IBA	Process
GO:0010469	regulation of signaling receptor activity	-	IEA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0030126	COPI vesicle coat	21873635.	IBA	Component
GO:0030126	COPI vesicle coat	14729954.	IDA	Component
GO:0030126	COPI vesicle coat	-	ISS	Component
GO:0030133	transport vesicle	-	TAS	Component
GO:0030157	pancreatic juice secretion	1429581.	IDA	Process
GO:0070062	extracellular exosome	19199708.	HDA	Component