EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000122359 (Gene tree)
Gene ID: 311
Gene Symbol: ANXA11
Alias: ANX11
Full Name: annexin A11
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 54,789 bases
Position: chr10:80,150,889-80,205,677
Accession: 535
RBP type: non-canonical RBP
Summary: This gene encodes a member of the annexin family, a group of calcium-dependent phospholipid-binding proteins. Annexins have unique N-terminal domains and conserved C-terminal domains, which contain calcium-dependent phospholipid-binding sites. The encoded protein is a 56-kD antigen recognized by sera from patients with various autoimmune diseases. Several transcript variants encoding two different isoforms have been identified. [provided by RefSeq, Dec 2015]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000481805	ANXA11-210	793	-	-	- (aa)	-	-
ENST00000447489	ANXA11-206	750	-	ENSP00000405009	148 (aa)	-	H0Y6E1
ENST00000265447	ANXA11-201	2526	XM_005269741	ENSP00000265447	472 (aa)	XP_005269798	P50995
ENST00000422982	ANXA11-203	2534	XM_006717813	ENSP00000404412	505 (aa)	XP_006717876	P50995
ENST00000474545	ANXA11-209	550	-	-	- (aa)	-	-
ENST00000463340	ANXA11-207	377	-	-	- (aa)	-	-
ENST00000372231	ANXA11-202	6720	XM_005269742	ENSP00000361305	505 (aa)	XP_005269799	P50995
ENST00000463657	ANXA11-208	780	-	-	- (aa)	-	-
ENST00000438331	ANXA11-205	6965	XM_011539736	ENSP00000398610	505 (aa)	XP_011538038	P50995
ENST00000437799	ANXA11-204	610	-	ENSP00000414642	150 (aa)	-	Q5T0G7

Gene Model

Click here to download ENSG00000122359's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000122359	Pulmonary Disease, Chronic Obstructive	1E-10	23144326
ENSG00000122359	Pulmonary Surfactant-Associated Protein D	1E-10	23144326

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000122359	rs1953600	10	80151969	?	Sarcoidosis	22936702			Orphanet_797
ENSG00000122359	rs6585424	10	80173992	G	Chronic obstructive pulmonary disease-related biomarkers	23144326			EFO_0000341\|EFO_0005081

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000122359's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000122359	ANXA11	100	93.008	ENSMUSG00000021866	Anxa11	94	93.008	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0005509	calcium ion binding	21873635.	IBA	Function
GO:0005515	protein binding	21873635.	IBA	Function
GO:0005515	protein binding	9268363.12445460.15197175.18256029.25910212.	IPI	Function
GO:0005544	calcium-dependent phospholipid binding	21873635.	IBA	Function
GO:0005635	nuclear envelope	12601007.15197175.	IDA	Component
GO:0005635	nuclear envelope	12577318.	NAS	Component
GO:0005654	nucleoplasm	7508441.12601007.15197175.	IDA	Component
GO:0005654	nucleoplasm	12577318.	NAS	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	7508441.12601007.12805373.	IDA	Component
GO:0005819	spindle	12805373.15197175.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0006909	phagocytosis	21873635.	IBA	Process
GO:0006909	phagocytosis	9188810.	IEP	Process
GO:0008429	phosphatidylethanolamine binding	21873635.	IBA	Function
GO:0016020	membrane	19946888.	HDA	Component
GO:0023026	MHC class II protein complex binding	20458337.	HDA	Function
GO:0030496	midbody	15197175.	IDA	Component
GO:0032506	cytokinetic process	21873635.	IBA	Process
GO:0032506	cytokinetic process	15197175.	IMP	Process
GO:0042470	melanosome	-	IEA	Component
GO:0042581	specific granule	9188810.	IDA	Component
GO:0042582	azurophil granule	9188810.	IDA	Component
GO:0044548	S100 protein binding	21873635.	IBA	Function
GO:0044548	S100 protein binding	12577318.19724273.	IPI	Function
GO:0045335	phagocytic vesicle	9188810.	IDA	Component
GO:0048306	calcium-dependent protein binding	21873635.	IBA	Function
GO:0048306	calcium-dependent protein binding	11883939.12445460.	IPI	Function
GO:0051592	response to calcium ion	21873635.	IBA	Process
GO:0051592	response to calcium ion	9188810.12601007.	IDA	Process
GO:0062023	collagen-containing extracellular matrix	25037231.28344315.	HDA	Component
GO:0070062	extracellular exosome	19056867.20458337.23533145.	HDA	Component

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
23579219	Feasibility of proposed single-nucleotide polymorphisms as predictive markers for targeted regimens in metastatic colorectal cancer.	Br J Cancer	2013 May 14	Kim JC	doi: 10.1038/bjc.2013.163
19484149	Suppression of annexin A11 in ovarian cancer: implications in chemoresistance.	Neoplasia	2009 Jun	Song J	-
29306955	Downregulation of Annexin A11 (ANXA11) Inhibits Cell Proliferation, Invasion, and Migration via the AKT/GSK-3β Pathway in Gastric Cancer.	Med Sci Monit	2018 Jan 7	Hua K	-

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr10	80167300	Missense_Mutation	novel	G192V	0.38
BLCA	chr10	80169303	Missense_Mutation	NA	G76E	0.26
BLCA	chr10	80159166	Missense_Mutation	rs745864099	R404W	0.24
BLCA	chr10	80170859	Missense_Mutation	rs142083484	G38R	0.38
BLCA	chr10	80172832	Silent	NA	P10P	0.29
BRCA	chr10	80163536	Missense_Mutation	NA	Q343E	0.19
BRCA	chr10	80155780	3'UTR	novel		0.2
BRCA	chr10	80155349	3'UTR	novel		0.58
BRCA	chr10	80161949	Missense_Mutation	novel	A389D	0.16
BRCA	chr10	80155754	3'UTR	novel		0.42
CESC	chr10	80155309	3'UTR	novel		0.45
CESC	chr10	80157733	Missense_Mutation	rs148593238	R456C	0.47
CESC	chr10	80169169	Missense_Mutation	novel	P121S	0.35
CESC	chr10	80163609	Missense_Mutation	NA	F318L	0.2
CHOL	chr10	80155300	3'UTR	novel		0.39
COAD	chr10	80164128	Nonsense_Mutation	NA	E292*	0.4
COAD	chr10	80172867	Splice_Region	NA		0.36
COAD	chr10	80157977	Missense_Mutation	novel	K442T	0.22
COAD	chr10	80169122	Frame_Shift_Del	rs771435989	*G137Dfs14**	0.37
COAD	chr10	80157676	Missense_Mutation	rs368132715	R475W	0.47
COAD	chr10	80169122	Frame_Shift_Del	rs771435989	*G137Dfs14**	0.39
COAD	chr10	80168987	Silent	novel	P181P	0.17
COAD	chr10	80155633	3'UTR	novel		0.28
COAD	chr10	80164105	Silent	rs773985331	L299L	0.21
COAD	chr10	80157675	Missense_Mutation	rs146644733	R475Q	0.26
COAD	chr10	80166198	Splice_Site	novel	X249_splice	0.33
COAD	chr10	80169187	Missense_Mutation	novel	S115T	0.36
COAD	chr10	80170834	Missense_Mutation	rs762084152	A46V	0.4
DLBC	chr10	80172814	Silent	novel	A16A	0.13
DLBC	chr10	80170841	Missense_Mutation	NA	T44S	0.33
ESCA	chr10	80163401	Missense_Mutation	novel	N345T	0.29
ESCA	chr10	80155556	3'UTR	novel		0.14
ESCA	chr10	80159186	Missense_Mutation	novel	E397V	0.11
ESCA	chr10	80159187	Nonsense_Mutation	novel	E397*	0.13
GBM	chr10	80159131	Silent	rs139193001	S415S	0.33
GBM	chr10	80164079	Missense_Mutation	rs535327650	R308Q	0.3
HNSC	chr10	80169210	Missense_Mutation	novel	P107R	0.44
HNSC	chr10	80155885	Missense_Mutation	novel	I496F	0.22
HNSC	chr10	80162005	Silent	novel	N370N	0.47
HNSC	chr10	80170805	Missense_Mutation	novel	G56R	0.3
HNSC	chr10	80170806	Silent	rs372441196	S55S	0.3
HNSC	chr10	80166180	Silent	novel	L254L	0.25
HNSC	chr10	80163346	Splice_Region	novel		0.38
KIRP	chr10	80167249	Missense_Mutation	NA	L209R	0.52
LAML	chr10	80166954	Missense_Mutation	novel	L227Q	0.29
LGG	chr10	80157980	Missense_Mutation	novel	N441S	0.34
LIHC	chr10	80166950	Silent	novel	G228G	0.45
LUAD	chr10	80164097	Missense_Mutation	novel	R302L	0.07
LUAD	chr10	80170895	Missense_Mutation	novel	A26S	0.27
LUAD	chr10	80170841	Missense_Mutation	NA	T44S	0.25
LUAD	chr10	80166929	Silent	NA	R235R	0.33
LUAD	chr10	80166880	Intron	novel		0.2
LUAD	chr10	80166917	Silent	NA	L239L	0.5
LUAD	chr10	80164102	Frame_Shift_Ins	novel	*S301Dfs8**	0.09
LUAD	chr10	80169251	Silent	rs763539929	P93P	0.3
LUSC	chr10	80159118	Nonsense_Mutation	NA	E420*	0.25
LUSC	chr10	80159119	Missense_Mutation	novel	E419D	0.25
LUSC	chr10	80157982	Silent	NA	L440L	0.14
LUSC	chr10	80169341	Frame_Shift_Del	novel	*T64Hfs87**	0.4
LUSC	chr10	80159113	Silent	novel	G421G	0.23
OV	chr10	80166171	Silent	novel	E257E	0.19
OV	chr10	80157698	Nonsense_Mutation	novel	*D468Efs9**	0.16
PAAD	chr10	80169171	Missense_Mutation	novel	Y120C	0.33
PAAD	chr10	80170849	Missense_Mutation	novel	N41S	0.07
PAAD	chr10	80170817	Missense_Mutation	rs774025846	D52Y	0.05
PRAD	chr10	80157697	Missense_Mutation	NA	D468Y	0.07
PRAD	chr10	80155795	3'UTR	novel		0.31
SKCM	chr10	80169354	Missense_Mutation	novel	A59V	0.15
SKCM	chr10	80157642	Missense_Mutation	rs778082972	S486L	0.28
SKCM	chr10	80169119	Silent	NA	G137G	0.23
SKCM	chr10	80155890	Missense_Mutation	novel	R494Q	0.2
SKCM	chr10	80172862	5'UTR	novel		0.17
SKCM	chr10	80158000	Silent	NA	A434A	0.28
SKCM	chr10	80168995	Missense_Mutation	NA	V179I	0.55
SKCM	chr10	80170860	Silent	rs199500343	I37I	0.18
SKCM	chr10	80164087	Frame_Shift_Ins	novel	*H306Afs42**	0.4
SKCM	chr10	80164090	Frame_Shift_Del	novel	*I298Mfs7**	0.4
SKCM	chr10	80159163	Missense_Mutation	rs778270793	D405N	0.38
STAD	chr10	80157707	Silent	rs374382845	T464T	0.19
STAD	chr10	80166103	Missense_Mutation	novel	E280A	0.24
STAD	chr10	80167247	Missense_Mutation	rs768664021	R210W	0.11
STAD	chr10	80164101	Missense_Mutation	novel	S301T	0.22
STAD	chr10	80155866	Missense_Mutation	NA	G502D	0.22
UCEC	chr10	80155300	3'UTR	novel		0.63
UCEC	chr10	80155300	3'UTR	novel		0.44
UCEC	chr10	80169150	Frame_Shift_Del	novel	*P127Lfs24**	0.5
UCEC	chr10	80170863	Frame_Shift_Del	novel	*I37Sfs114**	0.34
UCEC	chr10	80170864	Missense_Mutation	rs199988035	P36H	0.33
UCEC	chr10	80155743	3'UTR	novel		0.31
UCEC	chr10	80157666	Missense_Mutation	novel	G478D	0.17
UCEC	chr10	80157717	Missense_Mutation	novel	R461H	0.22
UCEC	chr10	80155695	3'UTR	novel		0.24
UCEC	chr10	80159169	Missense_Mutation	novel	G403C	0.08
UCEC	chr10	80155309	3'UTR	novel		0.47
UCEC	chr10	80155300	3'UTR	novel		0.75
UCEC	chr10	80155300	3'UTR	novel		0.46
UCEC	chr10	80155300	3'UTR	novel		0.4
UCEC	chr10	80168987	Silent	novel	P181P	0.26
UCEC	chr10	80155335	3'UTR	novel		0.17
UCEC	chr10	80157991	Silent	rs140115990	A437A	0.14
UCEC	chr10	80166911	Silent	novel	S241S	0.39
UCEC	chr10	80167304	Nonsense_Mutation	rs541812422	R191*	0.63
UCEC	chr10	80169048	Missense_Mutation	novel	P161H	0.21
UCEC	chr10	80167281	Silent	rs754293239	P198P	0.11
UCEC	chr10	80155349	3'UTR	novel		0.15
UCEC	chr10	80155712	3'UTR	novel		0.35
UCEC	chr10	80169111	Missense_Mutation	novel	P140L	0.28
UCEC	chr10	80170882	Missense_Mutation	novel	P30H	0.43
UCEC	chr10	80155300	3'UTR	novel		0.44
UCEC	chr10	80155787	3'UTR	novel		0.49
UCEC	chr10	80162017	Silent	rs141456938	A366A	0.42
UCEC	chr10	80155817	3'UTR	novel		0.48
UCEC	chr10	80157728	Silent	novel	I457I	0.48
UCEC	chr10	80163535	Frame_Shift_Ins	NA	*Q343Lfs51**	0.39
UCEC	chr10	80155707	3'UTR	novel		0.25
UCEC	chr10	80155471	3'UTR	novel		0.26
UCEC	chr10	80157974	Missense_Mutation	novel	A443D	0.28
UCEC	chr10	80161934	Splice_Site	novel	X394_splice	0.16
UCEC	chr10	80169005	Silent	novel	G175G	0.53
UCEC	chr10	80163557	Missense_Mutation	rs368700483	R336W	0.43
UCEC	chr10	80155300	3'UTR	novel		0.31
UCEC	chr10	80155300	3'UTR	novel		0.47
UCEC	chr10	80157717	Missense_Mutation	novel	R461H	0.33
UCEC	chr10	80158012	Missense_Mutation	novel	K430N	0.25
UCEC	chr10	80170898	Missense_Mutation	NA	G25C	0.7
UCEC	chr10	80166935	Missense_Mutation	novel	K233N	0.52
UCEC	chr10	80155801	3'UTR	novel		0.26
UCEC	chr10	80166935	Silent	novel	K233K	0.3
UCEC	chr10	80168987	Silent	novel	P181P	0.43
UCEC	chr10	80166935	Silent	novel	K233K	0.38
UCEC	chr10	80169122	Frame_Shift_Del	rs771435989	*G137Dfs14**	0.37
UCEC	chr10	80155300	3'UTR	novel		0.4
UCEC	chr10	80155248	3'UTR	novel		0.26
UCEC	chr10	80159175	Missense_Mutation	novel	M401L	0.41
UCEC	chr10	80170878	Silent	rs139801764	P31P	0.48
UCEC	chr10	80155509	3'UTR	novel		0.12
UCEC	chr10	80155751	3'UTR	novel		0.29
UCEC	chr10	80164126	Silent	novel	E292E	0.23
UCEC	chr10	80163583	Missense_Mutation	rs149646596	R327Q	0.49
UCEC	chr10	80155597	3'UTR	novel		0.32
UCEC	chr10	80155300	3'UTR	novel		0.46
UCEC	chr10	80157745	Missense_Mutation	rs150671497	R452W	0.47
UCEC	chr10	80163398	Missense_Mutation	rs749606073	R346H	0.48

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.1222	0.19593
BRCA	AMP	0.1083	4.6445e-05
PAAD	DEL	0.0924	0.169
READ	AMP	0.0606	0.13718
THCA	DEL	0.022	0.011063
UCS	DEL	0.2143	0.1218

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0028	Kaplan-Meier Survival Analysis
KIRC	0.011	Kaplan-Meier Survival Analysis
STAD	0.0033	Kaplan-Meier Survival Analysis
MESO	0.00082	Kaplan-Meier Survival Analysis
ACC	0.038	Kaplan-Meier Survival Analysis
LUSC	0.015	Kaplan-Meier Survival Analysis
BRCA	0.038	Kaplan-Meier Survival Analysis
KIRP	0.00012	Kaplan-Meier Survival Analysis
PAAD	0.028	Kaplan-Meier Survival Analysis
CESC	0.026	Kaplan-Meier Survival Analysis
READ	0.025	Kaplan-Meier Survival Analysis
LAML	0.00049	Kaplan-Meier Survival Analysis
KICH	0.039	Kaplan-Meier Survival Analysis
GBM	0.0068	Kaplan-Meier Survival Analysis
LIHC	0.011	Kaplan-Meier Survival Analysis
UVM	0.047	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742