EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000122687 (Gene tree)
Gene ID: 29960
Gene Symbol: MRM2
Alias: FJH1|RRMJ2|FTSJ2
Full Name: mitochondrial rRNA methyltransferase 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 7,968 bases
Position: chr7:2,234,231-2,242,198
Accession: 16352
RBP type: canonical RBP
Summary: The protein encoded by this gene is a member of the S-adenosylmethionine-binding protein family. It is a nucleolar protein and it may be involved in the processing and modification of rRNA. This gene has been suggested to be involved in cell cycle control and DNA repair. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000242257	FtsJ	PF01728.19	2.2e-52	1	1
ENSP00000392343	FtsJ	PF01728.19	2.2e-52	1	1
ENSP00000384423	FtsJ	PF01728.19	6e-32	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000242257	MRM2-201	1601	-	ENSP00000242257	246 (aa)	-	Q9UI43
ENST00000486040	MRM2-205	2511	-	ENSP00000498090	155 (aa)	-	UPI0000168663
ENST00000407040	MRM2-202	582	-	ENSP00000384423	152 (aa)	-	E9PGN6
ENST00000440306	MRM2-203	1570	-	ENSP00000392343	246 (aa)	-	Q9UI43
ENST00000467199	MRM2-204	1819	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000122687's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000122687	Attention Deficit Disorder with Hyperactivity	5E-6	23453885
ENSG00000122687	Bipolar Disorder	5E-6	23453885
ENSG00000122687	Child Development Disorders, Pervasive	5E-6	23453885
ENSG00000122687	Depressive Disorder	5E-6	23453885
ENSG00000122687	Schizophrenia	5E-6	23453885

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000122687's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000122687	MRM2	84	32.283	ENSG00000108592	FTSJ3	90	40.708
ENSG00000122687	MRM2	91	31.655	ENSG00000068438	FTSJ1	62	33.493

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000122687	MRM2	95	55.932	ENSAPOG00000001337	mrm2	98	55.932	Acanthochromis_polyacanthus
ENSG00000122687	MRM2	98	79.424	ENSAMEG00000003654	MRM2	98	79.424	Ailuropoda_melanoleuca
ENSG00000122687	MRM2	92	54.701	ENSACIG00000012468	mrm2	96	54.701	Amphilophus_citrinellus
ENSG00000122687	MRM2	95	56.356	ENSAOCG00000012664	mrm2	98	56.356	Amphiprion_ocellaris
ENSG00000122687	MRM2	95	56.356	ENSAPEG00000016487	mrm2	98	56.356	Amphiprion_percula
ENSG00000122687	MRM2	93	56.277	ENSATEG00000003512	mrm2	97	56.277	Anabas_testudineus
ENSG00000122687	MRM2	97	61.506	ENSACAG00000009089	MRM2	99	61.506	Anolis_carolinensis
ENSG00000122687	MRM2	100	89.431	ENSANAG00000030056	MRM2	100	89.431	Aotus_nancymaae
ENSG00000122687	MRM2	91	54.348	ENSACLG00000004683	mrm2	97	56.279	Astatotilapia_calliptera
ENSG00000122687	MRM2	86	57.346	ENSAMXG00000042804	mrm2	89	56.744	Astyanax_mexicanus
ENSG00000122687	MRM2	98	84.711	ENSBTAG00000002477	MRM2	99	84.711	Bos_taurus
ENSG00000122687	MRM2	88	42.754	WBGene00009735	F45G2.9	97	41.935	Caenorhabditis_elegans
ENSG00000122687	MRM2	100	90.650	ENSCJAG00000001457	-	100	90.650	Callithrix_jacchus
ENSG00000122687	MRM2	100	86.992	ENSCJAG00000039994	-	100	86.992	Callithrix_jacchus
ENSG00000122687	MRM2	95	81.197	ENSCAFG00000016434	MRM2	95	81.197	Canis_familiaris
ENSG00000122687	MRM2	97	80.672	ENSCAFG00020020754	MRM2	97	80.672	Canis_lupus_dingo
ENSG00000122687	MRM2	97	84.874	ENSCHIG00000013183	MRM2	98	84.874	Capra_hircus
ENSG00000122687	MRM2	98	85.477	ENSTSYG00000036882	MRM2	95	85.477	Carlito_syrichta
ENSG00000122687	MRM2	97	81.633	ENSCAPG00000016972	MRM2	100	80.870	Cavia_aperea
ENSG00000122687	MRM2	97	81.633	ENSCPOG00000020743	MRM2	96	78.423	Cavia_porcellus
ENSG00000122687	MRM2	100	91.057	ENSCCAG00000032721	MRM2	100	91.057	Cebus_capucinus
ENSG00000122687	MRM2	100	95.935	ENSCATG00000029383	MRM2	100	95.935	Cercocebus_atys
ENSG00000122687	MRM2	99	95.885	ENSCSAG00000017584	MRM2	95	95.885	Chlorocebus_sabaeus
ENSG00000122687	MRM2	98	83.402	ENSCHOG00000013900	MRM2	98	83.402	Choloepus_hoffmanni
ENSG00000122687	MRM2	97	65.546	ENSCPBG00000020643	MRM2	97	65.546	Chrysemys_picta_bellii
ENSG00000122687	MRM2	57	42.657	ENSCING00000013861	-	68	42.657	Ciona_intestinalis
ENSG00000122687	MRM2	100	94.715	ENSCANG00000035367	MRM2	100	94.715	Colobus_angolensis_palliatus
ENSG00000122687	MRM2	99	79.424	ENSCGRG00001023201	Mrm2	99	79.424	Cricetulus_griseus_chok1gshd
ENSG00000122687	MRM2	99	79.424	ENSCGRG00000014287	Mrm2	99	79.424	Cricetulus_griseus_crigri
ENSG00000122687	MRM2	89	54.815	ENSCSEG00000021245	mrm2	88	54.795	Cynoglossus_semilaevis
ENSG00000122687	MRM2	92	54.348	ENSCVAG00000013677	mrm2	96	54.348	Cyprinodon_variegatus
ENSG00000122687	MRM2	90	54.015	ENSDARG00000075368	mrm2	83	55.093	Danio_rerio
ENSG00000122687	MRM2	98	83.058	ENSDNOG00000049799	-	95	83.058	Dasypus_novemcinctus
ENSG00000122687	MRM2	100	78.313	ENSDNOG00000008842	-	100	78.313	Dasypus_novemcinctus
ENSG00000122687	MRM2	96	82.192	ENSDORG00000001318	Mrm2	96	82.533	Dipodomys_ordii
ENSG00000122687	MRM2	87	41.860	FBgn0038737	CG11447	86	41.860	Drosophila_melanogaster
ENSG00000122687	MRM2	92	50.000	ENSEBUG00000002997	mrm2	91	50.000	Eptatretus_burgeri
ENSG00000122687	MRM2	98	85.062	ENSEASG00005021156	MRM2	77	85.062	Equus_asinus_asinus
ENSG00000122687	MRM2	98	85.892	ENSECAG00000012227	MRM2	77	85.892	Equus_caballus
ENSG00000122687	MRM2	98	49.167	ENSEEUG00000009572	-	99	49.167	Erinaceus_europaeus
ENSG00000122687	MRM2	95	50.427	ENSELUG00000020209	mrm2	97	50.427	Esox_lucius
ENSG00000122687	MRM2	98	82.573	ENSFCAG00000024756	MRM2	92	82.573	Felis_catus
ENSG00000122687	MRM2	93	58.865	ENSFALG00000013915	MRM2	89	62.617	Ficedula_albicollis
ENSG00000122687	MRM2	97	83.784	ENSFDAG00000004774	MRM2	100	80.488	Fukomys_damarensis
ENSG00000122687	MRM2	92	56.522	ENSFHEG00000016343	mrm2	96	56.522	Fundulus_heteroclitus
ENSG00000122687	MRM2	93	51.489	ENSGMOG00000005078	mrm2	98	51.489	Gadus_morhua
ENSG00000122687	MRM2	95	61.538	ENSGALG00000004238	MRM2	96	61.538	Gallus_gallus
ENSG00000122687	MRM2	92	54.545	ENSGAFG00000018090	mrm2	96	54.545	Gambusia_affinis
ENSG00000122687	MRM2	93	55.702	ENSGACG00000014126	mrm2	98	55.172	Gasterosteus_aculeatus
ENSG00000122687	MRM2	98	65.289	ENSGAGG00000003680	MRM2	98	65.289	Gopherus_agassizii
ENSG00000122687	MRM2	100	98.684	ENSGGOG00000011963	MRM2	100	98.684	Gorilla_gorilla
ENSG00000122687	MRM2	91	54.348	ENSHBUG00000002875	mrm2	97	56.279	Haplochromis_burtoni
ENSG00000122687	MRM2	97	84.459	ENSHGLG00000011288	MRM2	100	80.894	Heterocephalus_glaber_female
ENSG00000122687	MRM2	97	84.459	ENSHGLG00100018408	FTSJ2	100	81.301	Heterocephalus_glaber_male
ENSG00000122687	MRM2	91	57.246	ENSHCOG00000006971	mrm2	96	54.867	Hippocampus_comes
ENSG00000122687	MRM2	93	52.966	ENSIPUG00000018560	mrm2	98	52.966	Ictalurus_punctatus
ENSG00000122687	MRM2	99	80.000	ENSSTOG00000015460	MRM2	99	80.000	Ictidomys_tridecemlineatus
ENSG00000122687	MRM2	96	78.481	ENSJJAG00000012625	Mrm2	98	78.481	Jaculus_jaculus
ENSG00000122687	MRM2	93	56.710	ENSKMAG00000018800	mrm2	95	56.710	Kryptolebias_marmoratus
ENSG00000122687	MRM2	93	55.603	ENSLBEG00000016942	mrm2	96	55.603	Labrus_bergylta
ENSG00000122687	MRM2	90	60.360	ENSLACG00000016579	MRM2	93	60.360	Latimeria_chalumnae
ENSG00000122687	MRM2	91	57.554	ENSLOCG00000001431	mrm2	89	59.259	Lepisosteus_oculatus
ENSG00000122687	MRM2	99	81.893	ENSLAFG00000008777	MRM2	99	81.893	Loxodonta_africana
ENSG00000122687	MRM2	100	96.341	ENSMFAG00000046197	MRM2	100	96.341	Macaca_fascicularis
ENSG00000122687	MRM2	100	96.341	ENSMMUG00000017020	MRM2	100	96.341	Macaca_mulatta
ENSG00000122687	MRM2	100	95.935	ENSMNEG00000032087	MRM2	100	95.935	Macaca_nemestrina
ENSG00000122687	MRM2	100	96.341	ENSMLEG00000037490	MRM2	100	96.341	Mandrillus_leucophaeus
ENSG00000122687	MRM2	91	55.263	ENSMAMG00000001903	mrm2	95	55.263	Mastacembelus_armatus
ENSG00000122687	MRM2	92	54.348	ENSMZEG00005022549	mrm2	96	54.348	Maylandia_zebra
ENSG00000122687	MRM2	100	79.268	ENSMAUG00000018749	Mrm2	100	79.268	Mesocricetus_auratus
ENSG00000122687	MRM2	100	80.081	ENSMOCG00000014075	Mrm2	100	80.081	Microtus_ochrogaster
ENSG00000122687	MRM2	93	56.028	ENSMMOG00000020424	mrm2	97	55.844	Mola_mola
ENSG00000122687	MRM2	93	54.310	ENSMALG00000003782	mrm2	97	54.310	Monopterus_albus
ENSG00000122687	MRM2	98	79.752	MGP_CAROLIEiJ_G0027946	Mrm2	98	79.752	Mus_caroli
ENSG00000122687	MRM2	99	79.835	ENSMUSG00000029557	Mrm2	99	79.835	Mus_musculus
ENSG00000122687	MRM2	98	79.339	MGP_PahariEiJ_G0024518	Mrm2	98	79.339	Mus_pahari
ENSG00000122687	MRM2	98	79.668	MGP_SPRETEiJ_G0028950	Mrm2	98	79.668	Mus_spretus
ENSG00000122687	MRM2	95	79.828	ENSMPUG00000017911	MRM2	95	79.828	Mustela_putorius_furo
ENSG00000122687	MRM2	98	80.165	ENSMLUG00000011042	MRM2	98	80.165	Myotis_lucifugus
ENSG00000122687	MRM2	100	78.455	ENSNGAG00000013483	Mrm2	100	78.455	Nannospalax_galili
ENSG00000122687	MRM2	91	55.072	ENSNBRG00000015997	mrm2	97	56.744	Neolamprologus_brichardi
ENSG00000122687	MRM2	100	97.154	ENSNLEG00000034773	MRM2	95	97.154	Nomascus_leucogenys
ENSG00000122687	MRM2	99	72.428	ENSMEUG00000010815	MRM2	100	72.428	Notamacropus_eugenii
ENSG00000122687	MRM2	57	72.857	ENSOPRG00000009012	-	92	72.857	Ochotona_princeps
ENSG00000122687	MRM2	99	81.457	ENSODEG00000009300	-	99	81.457	Octodon_degus
ENSG00000122687	MRM2	91	54.348	ENSONIG00000001321	mrm2	97	56.279	Oreochromis_niloticus
ENSG00000122687	MRM2	92	71.429	ENSOANG00000000253	MRM2	84	70.852	Ornithorhynchus_anatinus
ENSG00000122687	MRM2	93	55.319	ENSORLG00000029537	mrm2	92	57.746	Oryzias_latipes
ENSG00000122687	MRM2	93	56.028	ENSORLG00020006151	mrm2	85	58.216	Oryzias_latipes_hni
ENSG00000122687	MRM2	93	55.319	ENSORLG00015019423	mrm2	86	57.477	Oryzias_latipes_hsok
ENSG00000122687	MRM2	93	56.028	ENSOMEG00000024010	mrm2	87	57.944	Oryzias_melastigma
ENSG00000122687	MRM2	99	85.185	ENSOGAG00000000148	MRM2	99	85.185	Otolemur_garnettii
ENSG00000122687	MRM2	93	81.560	ENSOARG00000005341	MRM2	81	75.847	Ovis_aries
ENSG00000122687	MRM2	100	98.684	ENSPPAG00000033545	MRM2	100	98.765	Pan_paniscus
ENSG00000122687	MRM2	98	82.158	ENSPPRG00000004073	MRM2	92	82.158	Panthera_pardus
ENSG00000122687	MRM2	98	81.328	ENSPTIG00000016169	MRM2	99	81.328	Panthera_tigris_altaica
ENSG00000122687	MRM2	100	98.684	ENSPTRG00000018857	MRM2	100	98.684	Pan_troglodytes
ENSG00000122687	MRM2	90	52.489	ENSPKIG00000010326	mrm2	92	52.489	Paramormyrops_kingsleyae
ENSG00000122687	MRM2	87	58.140	ENSPMGG00000000831	mrm2	90	58.140	Periophthalmus_magnuspinnatus
ENSG00000122687	MRM2	100	80.488	ENSPEMG00000021422	Mrm2	100	80.488	Peromyscus_maniculatus_bairdii
ENSG00000122687	MRM2	89	69.118	ENSPCIG00000003826	MRM2	99	71.292	Phascolarctos_cinereus
ENSG00000122687	MRM2	92	55.652	ENSPFOG00000015171	mrm2	96	55.652	Poecilia_formosa
ENSG00000122687	MRM2	92	55.652	ENSPLAG00000012672	mrm2	96	55.652	Poecilia_latipinna
ENSG00000122687	MRM2	93	56.738	ENSPMEG00000014266	mrm2	97	55.365	Poecilia_mexicana
ENSG00000122687	MRM2	91	58.696	ENSPREG00000008682	mrm2	85	59.538	Poecilia_reticulata
ENSG00000122687	MRM2	100	97.561	ENSPPYG00000017310	MRM2	100	97.561	Pongo_abelii
ENSG00000122687	MRM2	98	79.339	ENSPCAG00000013372	MRM2	98	79.339	Procavia_capensis
ENSG00000122687	MRM2	100	86.992	ENSPCOG00000027704	MRM2	100	86.992	Propithecus_coquereli
ENSG00000122687	MRM2	94	82.759	ENSPVAG00000000063	MRM2	97	82.759	Pteropus_vampyrus
ENSG00000122687	MRM2	92	54.348	ENSPNYG00000009165	mrm2	96	54.348	Pundamilia_nyererei
ENSG00000122687	MRM2	93	55.085	ENSPNAG00000021409	mrm2	98	55.085	Pygocentrus_nattereri
ENSG00000122687	MRM2	100	77.642	ENSRNOG00000043267	Mrm2	100	77.642	Rattus_norvegicus
ENSG00000122687	MRM2	99	94.694	ENSRBIG00000032469	MRM2	100	94.694	Rhinopithecus_bieti
ENSG00000122687	MRM2	99	94.694	ENSRROG00000044723	MRM2	100	94.694	Rhinopithecus_roxellana
ENSG00000122687	MRM2	100	90.244	ENSSBOG00000020482	-	100	90.244	Saimiri_boliviensis_boliviensis
ENSG00000122687	MRM2	100	90.132	ENSSBOG00000035630	-	100	90.132	Saimiri_boliviensis_boliviensis
ENSG00000122687	MRM2	99	72.840	ENSSHAG00000016937	MRM2	99	72.840	Sarcophilus_harrisii
ENSG00000122687	MRM2	93	53.782	ENSSFOG00015005673	mrm2	96	53.782	Scleropages_formosus
ENSG00000122687	MRM2	93	55.844	ENSSMAG00000005720	mrm2	93	55.844	Scophthalmus_maximus
ENSG00000122687	MRM2	93	55.844	ENSSDUG00000018319	mrm2	97	55.844	Seriola_dumerili
ENSG00000122687	MRM2	92	55.000	ENSSLDG00000004692	MRM2	95	55.000	Seriola_lalandi_dorsalis
ENSG00000122687	MRM2	93	56.277	ENSSLDG00000009513	mrm2	97	56.277	Seriola_lalandi_dorsalis
ENSG00000122687	MRM2	96	63.291	ENSSPUG00000001830	MRM2	96	63.291	Sphenodon_punctatus
ENSG00000122687	MRM2	91	58.696	ENSSPAG00000010550	mrm2	95	57.895	Stegastes_partitus
ENSG00000122687	MRM2	98	76.543	ENSSSCG00000036247	MRM2	98	76.543	Sus_scrofa
ENSG00000122687	MRM2	93	60.284	ENSTGUG00000008183	MRM2	100	64.486	Taeniopygia_guttata
ENSG00000122687	MRM2	91	55.396	ENSTRUG00000025444	mrm2	84	55.869	Takifugu_rubripes
ENSG00000122687	MRM2	96	53.782	ENSTNIG00000005555	mrm2	96	53.782	Tetraodon_nigroviridis
ENSG00000122687	MRM2	99	81.633	ENSTBEG00000007714	MRM2	100	81.633	Tupaia_belangeri
ENSG00000122687	MRM2	98	82.988	ENSTTRG00000010687	MRM2	98	82.988	Tursiops_truncatus
ENSG00000122687	MRM2	94	79.310	ENSUAMG00000001643	MRM2	95	79.310	Ursus_americanus
ENSG00000122687	MRM2	91	77.698	ENSUMAG00000007103	MRM2	96	81.053	Ursus_maritimus
ENSG00000122687	MRM2	95	83.448	ENSVPAG00000007568	-	99	83.448	Vicugna_pacos
ENSG00000122687	MRM2	90	63.348	ENSVPAG00000002773	-	98	63.348	Vicugna_pacos
ENSG00000122687	MRM2	97	79.412	ENSVVUG00000004149	MRM2	97	79.412	Vulpes_vulpes
ENSG00000122687	MRM2	93	56.140	ENSXETG00000012559	mrm2	93	56.140	Xenopus_tropicalis
ENSG00000122687	MRM2	94	54.701	ENSXCOG00000016610	mrm2	97	54.701	Xiphophorus_couchianus
ENSG00000122687	MRM2	94	54.701	ENSXMAG00000009314	mrm2	97	54.701	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000451	rRNA 2'-O-methylation	-	TAS	Process
GO:0005730	nucleolus	11827451.	IDA	Component
GO:0005739	mitochondrion	21873635.	IBA	Component
GO:0005739	mitochondrion	-	ISS	Component
GO:0005759	mitochondrial matrix	-	TAS	Component
GO:0006364	rRNA processing	11827451.	NAS	Process
GO:0008650	rRNA (uridine-2'-O-)-methyltransferase activity	25074936.	EXP	Function
GO:0008650	rRNA (uridine-2'-O-)-methyltransferase activity	21873635.	IBA	Function
GO:0008650	rRNA (uridine-2'-O-)-methyltransferase activity	11827451.	NAS	Function
GO:0031167	rRNA methylation	11827451.	NAS	Process