EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000122884 (Gene tree)
Gene ID: 5033
Gene Symbol: P4HA1
Alias: C-P4Halpha(I)|P4HA
Full Name: prolyl 4-hydroxylase subunit alpha 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 89,758 bases
Position: chr10:73,007,217-73,096,974
Accession: 8546
RBP type: canonical RBP
Summary: This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000263556	2OG-FeII_Oxy	PF03171.20	7.1e-08	1	1
ENSP00000362099	2OG-FeII_Oxy	PF03171.20	7.1e-08	1	1
ENSP00000307318	2OG-FeII_Oxy	PF03171.20	7.1e-08	1	1
ENSP00000378353	2OG-FeII_Oxy	PF03171.20	7.1e-08	1	1
ENSP00000414464	2OG-FeII_Oxy	PF03171.20	0.00022	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000373008	P4HA1-203	2727	-	ENSP00000362099	534 (aa)	-	P13674
ENST00000440381	P4HA1-205	2790	-	ENSP00000414464	516 (aa)	-	P13674
ENST00000307116	P4HA1-202	2727	-	ENSP00000307318	534 (aa)	-	P13674
ENST00000464310	P4HA1-206	415	-	-	- (aa)	-	-
ENST00000394890	P4HA1-204	2844	-	ENSP00000378353	534 (aa)	-	P13674
ENST00000263556	P4HA1-201	2844	-	ENSP00000263556	534 (aa)	-	P13674

Gene Model

Click here to download ENSG00000122884's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00330	Arginine and proline metabolism	KEGG
hsa01100	Metabolic pathways	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000122884's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000122884	P4HA1	97	75.379	ENSAPOG00000005170	p4ha1b	99	74.449	Acanthochromis_polyacanthus
ENSG00000122884	P4HA1	100	99.064	ENSAMEG00000017009	P4HA1	100	99.064	Ailuropoda_melanoleuca
ENSG00000122884	P4HA1	97	75.483	ENSACIG00000007255	p4ha1b	99	74.765	Amphilophus_citrinellus
ENSG00000122884	P4HA1	97	76.046	ENSAOCG00000001647	p4ha1b	98	74.908	Amphiprion_ocellaris
ENSG00000122884	P4HA1	99	62.734	ENSAPEG00000010402	-	99	62.734	Amphiprion_percula
ENSG00000122884	P4HA1	97	76.046	ENSAPEG00000005243	p4ha1b	98	74.908	Amphiprion_percula
ENSG00000122884	P4HA1	97	76.952	ENSATEG00000009272	p4ha1b	98	76.394	Anabas_testudineus
ENSG00000122884	P4HA1	97	87.524	ENSAPLG00000009284	P4HA1	100	87.524	Anas_platyrhynchos
ENSG00000122884	P4HA1	100	86.245	ENSACAG00000000564	P4HA1	99	86.245	Anolis_carolinensis
ENSG00000122884	P4HA1	100	99.251	ENSANAG00000024545	P4HA1	100	99.667	Aotus_nancymaae
ENSG00000122884	P4HA1	97	74.291	ENSACLG00000021556	p4ha1b	98	75.484	Astatotilapia_calliptera
ENSG00000122884	P4HA1	100	74.259	ENSAMXG00000011123	p4ha1b	100	74.259	Astyanax_mexicanus
ENSG00000122884	P4HA1	100	97.753	ENSBTAG00000032996	P4HA1	100	97.753	Bos_taurus
ENSG00000122884	P4HA1	100	99.064	ENSCJAG00000007429	P4HA1	100	99.333	Callithrix_jacchus
ENSG00000122884	P4HA1	100	98.315	ENSCAFG00000014573	P4HA1	100	98.315	Canis_familiaris
ENSG00000122884	P4HA1	99	97.363	ENSCAFG00020023993	P4HA1	100	96.226	Canis_lupus_dingo
ENSG00000122884	P4HA1	100	97.753	ENSCHIG00000013957	P4HA1	100	97.753	Capra_hircus
ENSG00000122884	P4HA1	100	97.940	ENSTSYG00000004004	P4HA1	100	97.940	Carlito_syrichta
ENSG00000122884	P4HA1	100	97.004	ENSCPOG00000015701	P4HA1	100	97.667	Cavia_porcellus
ENSG00000122884	P4HA1	100	99.813	ENSCATG00000029618	P4HA1	100	100.000	Cercocebus_atys
ENSG00000122884	P4HA1	100	97.191	ENSCLAG00000017260	P4HA1	100	97.667	Chinchilla_lanigera
ENSG00000122884	P4HA1	100	99.625	ENSCSAG00000008626	P4HA1	100	99.625	Chlorocebus_sabaeus
ENSG00000122884	P4HA1	99	87.103	ENSCPBG00000007933	P4HA1	99	87.103	Chrysemys_picta_bellii
ENSG00000122884	P4HA1	100	99.813	ENSCANG00000033147	P4HA1	100	100.000	Colobus_angolensis_palliatus
ENSG00000122884	P4HA1	100	96.442	ENSCGRG00001007006	P4ha1	100	96.442	Cricetulus_griseus_chok1gshd
ENSG00000122884	P4HA1	100	96.442	ENSCGRG00000009371	P4ha1	100	96.442	Cricetulus_griseus_crigri
ENSG00000122884	P4HA1	100	73.889	ENSCSEG00000004939	p4ha1b	99	73.889	Cynoglossus_semilaevis
ENSG00000122884	P4HA1	99	73.234	ENSCVAG00000016433	p4ha1b	98	74.164	Cyprinodon_variegatus
ENSG00000122884	P4HA1	97	39.923	ENSDARG00000017038	zgc:152670	95	47.973	Danio_rerio
ENSG00000122884	P4HA1	97	75.862	ENSDARG00000071082	p4ha1b	99	74.164	Danio_rerio
ENSG00000122884	P4HA1	99	95.677	ENSDNOG00000013665	P4HA1	94	95.677	Dasypus_novemcinctus
ENSG00000122884	P4HA1	100	97.191	ENSDORG00000003405	P4ha1	100	97.191	Dipodomys_ordii
ENSG00000122884	P4HA1	99	61.101	ENSEBUG00000005379	p4ha1b	98	61.101	Eptatretus_burgeri
ENSG00000122884	P4HA1	99	96.981	ENSEASG00005016606	P4HA1	100	99.667	Equus_asinus_asinus
ENSG00000122884	P4HA1	99	96.981	ENSECAG00000012496	P4HA1	99	99.213	Equus_caballus
ENSG00000122884	P4HA1	85	94.156	ENSEEUG00000005542	P4HA1	85	94.156	Erinaceus_europaeus
ENSG00000122884	P4HA1	99	72.913	ENSELUG00000005913	p4ha1b	99	74.225	Esox_lucius
ENSG00000122884	P4HA1	100	98.689	ENSFCAG00000018673	P4HA1	100	98.689	Felis_catus
ENSG00000122884	P4HA1	99	86.355	ENSFALG00000012773	P4HA1	99	86.355	Ficedula_albicollis
ENSG00000122884	P4HA1	100	88.268	ENSFDAG00000007094	P4HA1	100	88.268	Fukomys_damarensis
ENSG00000122884	P4HA1	97	74.624	ENSFHEG00000022856	p4ha1b	98	73.905	Fundulus_heteroclitus
ENSG00000122884	P4HA1	95	71.124	ENSGMOG00000018948	p4ha1b	99	71.124	Gadus_morhua
ENSG00000122884	P4HA1	99	87.103	ENSGALG00000004325	P4HA1	100	86.916	Gallus_gallus
ENSG00000122884	P4HA1	97	76.000	ENSGAFG00000019818	p4ha1b	98	75.046	Gambusia_affinis
ENSG00000122884	P4HA1	97	73.208	ENSGACG00000010233	p4ha1b	99	72.593	Gasterosteus_aculeatus
ENSG00000122884	P4HA1	100	100.000	ENSGGOG00000015551	P4HA1	100	100.000	Gorilla_gorilla
ENSG00000122884	P4HA1	97	74.291	ENSHBUG00000015524	p4ha1b	98	73.655	Haplochromis_burtoni
ENSG00000122884	P4HA1	100	97.004	ENSHGLG00000011764	P4HA1	100	98.333	Heterocephalus_glaber_female
ENSG00000122884	P4HA1	95	74.903	ENSHCOG00000017152	p4ha1b	99	74.903	Hippocampus_comes
ENSG00000122884	P4HA1	97	75.483	ENSIPUG00000015157	P4HA1	99	74.480	Ictalurus_punctatus
ENSG00000122884	P4HA1	100	98.127	ENSSTOG00000027062	P4HA1	100	98.333	Ictidomys_tridecemlineatus
ENSG00000122884	P4HA1	100	96.067	ENSJJAG00000004232	P4ha1	100	96.333	Jaculus_jaculus
ENSG00000122884	P4HA1	97	75.706	ENSKMAG00000001588	p4ha1b	99	74.816	Kryptolebias_marmoratus
ENSG00000122884	P4HA1	97	75.335	ENSLBEG00000018911	p4ha1b	98	74.212	Labrus_bergylta
ENSG00000122884	P4HA1	98	81.905	ENSLACG00000010202	P4HA1	99	81.168	Latimeria_chalumnae
ENSG00000122884	P4HA1	99	79.026	ENSLOCG00000008546	p4ha1b	98	79.026	Lepisosteus_oculatus
ENSG00000122884	P4HA1	100	95.506	ENSLAFG00000002652	P4HA1	100	95.506	Loxodonta_africana
ENSG00000122884	P4HA1	100	99.813	ENSMFAG00000030507	P4HA1	100	100.000	Macaca_fascicularis
ENSG00000122884	P4HA1	100	99.806	ENSMMUG00000011274	P4HA1	100	100.000	Macaca_mulatta
ENSG00000122884	P4HA1	99	97.561	ENSMNEG00000011433	P4HA1	98	99.804	Macaca_nemestrina
ENSG00000122884	P4HA1	96	94.521	ENSMLEG00000043338	P4HA1	100	100.000	Mandrillus_leucophaeus
ENSG00000122884	P4HA1	97	74.763	ENSMAMG00000015854	p4ha1b	99	73.978	Mastacembelus_armatus
ENSG00000122884	P4HA1	97	74.291	ENSMZEG00005027421	p4ha1b	98	73.655	Maylandia_zebra
ENSG00000122884	P4HA1	99	86.778	ENSMGAG00000005554	P4HA1	100	88.054	Meleagris_gallopavo
ENSG00000122884	P4HA1	100	79.252	ENSMAUG00000011056	P4ha1	97	89.667	Mesocricetus_auratus
ENSG00000122884	P4HA1	100	99.251	ENSMICG00000031365	P4HA1	100	100.000	Microcebus_murinus
ENSG00000122884	P4HA1	100	96.255	ENSMOCG00000017531	P4ha1	100	96.255	Microtus_ochrogaster
ENSG00000122884	P4HA1	97	75.475	ENSMMOG00000008022	p4ha1b	99	75.139	Mola_mola
ENSG00000122884	P4HA1	100	91.061	ENSMODG00000000121	P4HA1	99	91.061	Monodelphis_domestica
ENSG00000122884	P4HA1	97	75.429	ENSMALG00000019674	p4ha1b	98	74.444	Monopterus_albus
ENSG00000122884	P4HA1	100	95.318	MGP_CAROLIEiJ_G0015342	P4ha1	100	95.318	Mus_caroli
ENSG00000122884	P4HA1	100	95.693	ENSMUSG00000019916	P4ha1	100	95.693	Mus_musculus
ENSG00000122884	P4HA1	100	96.255	MGP_PahariEiJ_G0030758	P4ha1	100	96.255	Mus_pahari
ENSG00000122884	P4HA1	100	95.693	MGP_SPRETEiJ_G0016153	P4ha1	100	95.693	Mus_spretus
ENSG00000122884	P4HA1	100	98.689	ENSMPUG00000003940	P4HA1	100	98.689	Mustela_putorius_furo
ENSG00000122884	P4HA1	100	98.315	ENSMLUG00000006548	P4HA1	100	98.315	Myotis_lucifugus
ENSG00000122884	P4HA1	100	98.127	ENSNGAG00000014487	P4ha1	100	98.127	Nannospalax_galili
ENSG00000122884	P4HA1	97	75.483	ENSNBRG00000014791	p4ha1b	99	75.141	Neolamprologus_brichardi
ENSG00000122884	P4HA1	100	87.828	ENSNLEG00000035416	P4HA1	99	97.095	Nomascus_leucogenys
ENSG00000122884	P4HA1	91	82.582	ENSMEUG00000010326	P4HA1	95	82.582	Notamacropus_eugenii
ENSG00000122884	P4HA1	100	86.142	ENSOPRG00000000990	P4HA1	100	86.142	Ochotona_princeps
ENSG00000122884	P4HA1	100	64.074	ENSODEG00000015164	P4HA1	100	94.969	Octodon_degus
ENSG00000122884	P4HA1	97	74.576	ENSONIG00000000737	p4ha1b	88	73.567	Oreochromis_niloticus
ENSG00000122884	P4HA1	80	93.240	ENSOANG00000001125	-	100	93.240	Ornithorhynchus_anatinus
ENSG00000122884	P4HA1	100	97.753	ENSOCUG00000009739	P4HA1	100	97.753	Oryctolagus_cuniculus
ENSG00000122884	P4HA1	97	74.953	ENSORLG00000005147	p4ha1b	100	75.775	Oryzias_latipes
ENSG00000122884	P4HA1	97	74.953	ENSORLG00020010911	p4ha1b	98	74.539	Oryzias_latipes_hni
ENSG00000122884	P4HA1	90	75.314	ENSORLG00015016175	p4ha1b	98	75.362	Oryzias_latipes_hsok
ENSG00000122884	P4HA1	97	76.616	ENSOMEG00000009962	p4ha1b	99	75.601	Oryzias_melastigma
ENSG00000122884	P4HA1	100	97.948	ENSOGAG00000003483	P4HA1	100	97.948	Otolemur_garnettii
ENSG00000122884	P4HA1	100	97.753	ENSOARG00000007348	P4HA1	100	97.753	Ovis_aries
ENSG00000122884	P4HA1	100	92.606	ENSPPAG00000030135	P4HA1	100	100.000	Pan_paniscus
ENSG00000122884	P4HA1	100	98.502	ENSPPRG00000002655	P4HA1	100	98.502	Panthera_pardus
ENSG00000122884	P4HA1	100	98.502	ENSPTIG00000007711	P4HA1	100	98.502	Panthera_tigris_altaica
ENSG00000122884	P4HA1	100	98.062	ENSPTRG00000002619	P4HA1	100	98.062	Pan_troglodytes
ENSG00000122884	P4HA1	100	99.813	ENSPANG00000022355	P4HA1	100	100.000	Papio_anubis
ENSG00000122884	P4HA1	99	76.217	ENSPKIG00000000438	p4ha1b	99	76.217	Paramormyrops_kingsleyae
ENSG00000122884	P4HA1	99	87.266	ENSPSIG00000016298	P4HA1	100	87.266	Pelodiscus_sinensis
ENSG00000122884	P4HA1	96	77.148	ENSPMGG00000007593	p4ha1b	99	75.188	Periophthalmus_magnuspinnatus
ENSG00000122884	P4HA1	100	95.880	ENSPEMG00000006561	P4ha1	100	95.880	Peromyscus_maniculatus_bairdii
ENSG00000122884	P4HA1	100	91.248	ENSPCIG00000018768	P4HA1	100	91.248	Phascolarctos_cinereus
ENSG00000122884	P4HA1	97	74.857	ENSPFOG00000018574	p4ha1b	98	74.307	Poecilia_formosa
ENSG00000122884	P4HA1	97	76.000	ENSPLAG00000012628	p4ha1b	99	74.593	Poecilia_latipinna
ENSG00000122884	P4HA1	97	74.857	ENSPMEG00000024082	p4ha1b	98	74.307	Poecilia_mexicana
ENSG00000122884	P4HA1	97	75.619	ENSPREG00000010003	p4ha1b	98	75.046	Poecilia_reticulata
ENSG00000122884	P4HA1	100	100.000	ENSPPYG00000002348	P4HA1	100	100.000	Pongo_abelii
ENSG00000122884	P4HA1	95	88.780	ENSPCOG00000017553	P4HA1	100	99.590	Propithecus_coquereli
ENSG00000122884	P4HA1	99	87.358	ENSPVAG00000012989	P4HA1	99	87.358	Pteropus_vampyrus
ENSG00000122884	P4HA1	97	74.480	ENSPNYG00000002443	p4ha1b	98	73.469	Pundamilia_nyererei
ENSG00000122884	P4HA1	100	73.247	ENSPNAG00000023149	p4ha1b	100	73.889	Pygocentrus_nattereri
ENSG00000122884	P4HA1	100	95.880	ENSRNOG00000050655	P4ha1	100	95.880	Rattus_norvegicus
ENSG00000122884	P4HA1	100	87.079	ENSRBIG00000035304	P4HA1	100	87.079	Rhinopithecus_bieti
ENSG00000122884	P4HA1	100	100.000	ENSRROG00000044078	P4HA1	100	100.000	Rhinopithecus_roxellana
ENSG00000122884	P4HA1	71	90.415	ENSSHAG00000008056	P4HA1	100	88.860	Sarcophilus_harrisii
ENSG00000122884	P4HA1	99	74.813	ENSSFOG00015009176	p4ha1b	100	76.078	Scleropages_formosus
ENSG00000122884	P4HA1	100	73.937	ENSSMAG00000019199	p4ha1b	99	73.937	Scophthalmus_maximus
ENSG00000122884	P4HA1	97	75.189	ENSSDUG00000016587	p4ha1b	98	74.492	Seriola_dumerili
ENSG00000122884	P4HA1	97	75.379	ENSSLDG00000016261	p4ha1b	98	74.677	Seriola_lalandi_dorsalis
ENSG00000122884	P4HA1	100	93.820	ENSSARG00000003275	P4HA1	100	93.820	Sorex_araneus
ENSG00000122884	P4HA1	99	87.266	ENSSPUG00000002624	P4HA1	99	87.266	Sphenodon_punctatus
ENSG00000122884	P4HA1	86	73.418	ENSSPAG00000011193	p4ha1b	100	73.418	Stegastes_partitus
ENSG00000122884	P4HA1	100	97.753	ENSSSCG00000010292	P4HA1	100	97.753	Sus_scrofa
ENSG00000122884	P4HA1	99	85.981	ENSTGUG00000004364	-	99	85.981	Taeniopygia_guttata
ENSG00000122884	P4HA1	99	72.844	ENSTRUG00000004081	p4ha1b	99	73.761	Takifugu_rubripes
ENSG00000122884	P4HA1	99	74.340	ENSTNIG00000017021	p4ha1b	99	74.340	Tetraodon_nigroviridis
ENSG00000122884	P4HA1	100	96.629	ENSTTRG00000009782	P4HA1	100	96.629	Tursiops_truncatus
ENSG00000122884	P4HA1	100	99.064	ENSUMAG00000009024	P4HA1	100	99.064	Ursus_maritimus
ENSG00000122884	P4HA1	100	87.453	ENSVPAG00000007253	P4HA1	100	87.453	Vicugna_pacos
ENSG00000122884	P4HA1	100	98.315	ENSVVUG00000022660	P4HA1	100	98.315	Vulpes_vulpes
ENSG00000122884	P4HA1	99	78.049	ENSXETG00000006154	p4ha1	98	76.548	Xenopus_tropicalis
ENSG00000122884	P4HA1	97	75.475	ENSXCOG00000010262	p4ha1b	99	74.307	Xiphophorus_couchianus
ENSG00000122884	P4HA1	97	75.717	ENSXMAG00000003889	p4ha1b	98	74.768	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004656	procollagen-proline 4-dioxygenase activity	21873635.	IBA	Function
GO:0005506	iron ion binding	-	IEA	Function
GO:0005515	protein binding	17500595.	IPI	Function
GO:0005739	mitochondrion	-	IDA	Component
GO:0005783	endoplasmic reticulum	21873635.	IBA	Component
GO:0005783	endoplasmic reticulum	-	IDA	Component
GO:0005788	endoplasmic reticulum lumen	-	TAS	Component
GO:0016020	membrane	19946888.	HDA	Component
GO:0016222	procollagen-proline 4-dioxygenase complex	-	IEA	Component
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	-	IEA	Function
GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline	21873635.	IBA	Process
GO:0030199	collagen fibril organization	-	IEA	Process
GO:0031418	L-ascorbic acid binding	-	IEA	Function
GO:0042802	identical protein binding	24207127.	IPI	Function
GO:0043231	intracellular membrane-bounded organelle	-	IDA	Component
GO:0055114	oxidation-reduction process	-	IEA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
30367042	Collagen prolyl 4-hydroxylase 1 is essential for HIF-1α stabilization and TNBC chemoresistance.	Nat Commun	2018 Oct 26	Xiong G	doi: 10.1038/s41467-018-06893-9.
30136751	MiR-122 inhibits epithelial mesenchymal transition by regulating P4HA1 in ovarian cancer cells.	Cell Biol Int	2018 Nov	Duan Y	doi: 10.1002/cbin.11052

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr10	73043930	Intron	novel		0.14
BLCA	chr10	73068933	Missense_Mutation	novel	D126H	0.09
BLCA	chr10	73053411	Frame_Shift_Del	novel	*V215Yfs20**	0.17
BLCA	chr10	73043955	Intron	novel		0.34
BLCA	chr10	73043928	Intron	novel		0.12
BLCA	chr10	73073815	Missense_Mutation	novel	D30G	0.49
BLCA	chr10	73073823	Missense_Mutation	novel	Q27H	0.16
BRCA	chr10	73007980	3'UTR	novel		0.43
BRCA	chr10	73043952	Intron	NA		0.15
BRCA	chr10	73008291	Splice_Region	novel	V512V	0.12
BRCA	chr10	73009833	Missense_Mutation	NA	C503F	0.28
BRCA	chr10	73068849	Missense_Mutation	NA	P154S	0.21
CESC	chr10	73096820	5'UTR	novel		0.22
CESC	chr10	73007487	3'UTR	novel		0.43
CESC	chr10	73046993	Missense_Mutation	novel	I337F	0.1
CESC	chr10	73045049	Splice_Region	novel	L360L	0.13
CESC	chr10	73096900	5'Flank	novel		0.4
COAD	chr10	73008164	3'UTR	novel		0.41
COAD	chr10	73051079	Silent	novel	L292L	0.09
COAD	chr10	73047070	Missense_Mutation	rs761463646	R311H	0.32
COAD	chr10	73053463	Silent	rs201200914	G197G	0.14
COAD	chr10	73043887	Intron	novel		0.33
COAD	chr10	73073766	Missense_Mutation	novel	I46M	0.28
COAD	chr10	73073778	Silent	novel	L42L	0.1
ESCA	chr10	73007256	3'UTR	novel		0.17
ESCA	chr10	73053575	Missense_Mutation	novel	S160Y	0.29
GBM	chr10	73051138	Missense_Mutation	novel	T272I	0.07
GBM	chr10	73046986	Missense_Mutation	rs183380808	R339H	0.22
GBM	chr10	73008291	Splice_Region	novel	V512V	0.03
GBM	chr10	73047070	Missense_Mutation	rs761463646	R311H	0.48
HNSC	chr10	73072074	Nonsense_Mutation	novel	E94*	0.2
HNSC	chr10	73053473	Frame_Shift_Del	novel	*L194Gfs2**	0.4
HNSC	chr10	73010993	Silent	novel	V471V	0.22
HNSC	chr10	73043899	Intron	novel		0.11
HNSC	chr10	73053395	Missense_Mutation	novel	D220G	0.19
HNSC	chr10	73053480	Missense_Mutation	novel	R192W	0.29
KIRC	chr10	73074807	Splice_Site	NA	X26_splice	0.33
KIRP	chr10	73051148	Nonsense_Mutation	NA	Q269*	0.53
LGG	chr10	73008199	3'UTR	novel		0.07
LGG	chr10	73046939	Missense_Mutation	novel	L355I	0.23
LIHC	chr10	73051054	Missense_Mutation	novel	M300T	0.59
LIHC	chr10	73008217	3'UTR	novel		0.36
LIHC	chr10	73043886	Intron	novel		0.71
LUAD	chr10	73051208	Missense_Mutation	novel	E249Q	0.1
LUAD	chr10	73051118	Missense_Mutation	NA	A279S	0.16
LUAD	chr10	73053549	Nonsense_Mutation	novel	E169*	0.2
LUAD	chr10	73053484	Silent	novel	A190A	0.1
LUAD	chr10	73045005	Missense_Mutation	rs145054165	T375M	0.35
LUAD	chr10	73051099	Missense_Mutation	novel	E285V	0.06
LUSC	chr10	73072085	Missense_Mutation	NA	R90H	0.19
LUSC	chr10	73053504	Missense_Mutation	novel	E184K	0.16
LUSC	chr10	73030332	Missense_Mutation	rs199926060	R396Q	0.32
LUSC	chr10	73051142	Missense_Mutation	novel	T271A	0.25
LUSC	chr10	73016862	Missense_Mutation	novel	H429R	0.34	2OG-FeII_Oxy
MESO	chr10	73068935	Missense_Mutation	novel	E125A	0.18
OV	chr10	73047015	Frame_Shift_Ins	novel	*E329Dfs3**	0.05
OV	chr10	73051224	Silent	NA	G243G	0.22
OV	chr10	73068905	Nonsense_Mutation	novel	L135*	0.07
OV	chr10	73074818	Missense_Mutation	novel	F22L	0.05
OV	chr10	73068969	Frame_Shift_Ins	novel	*L114Nfs2**	0.07
OV	chr10	73068970	Frame_Shift_Ins	novel	*L114Sfs9**	0.07
PAAD	chr10	73053399	Missense_Mutation	novel	G219R	0.07
PAAD	chr10	73068894	Missense_Mutation	novel	D139Y	0.38
PAAD	chr10	73008122	3'UTR	novel		0.19
PAAD	chr10	73047097	Missense_Mutation	NA	P302L	0.18
PRAD	chr10	73053506	Missense_Mutation	NA	T183R	0.1
PRAD	chr10	73045024	Missense_Mutation	rs201139791	I369V	0.15
PRAD	chr10	73046986	Missense_Mutation	rs183380808	R339H	0.35
READ	chr10	73045004	Silent	rs773651613	T375T	0.37
READ	chr10	73051161	Silent	NA	D264D	0.13
READ	chr10	73072140	Missense_Mutation	NA	K72Q	0.07
READ	chr10	73008132	3'UTR	novel		0.4
SKCM	chr10	73053463	Silent	NA	G197G	0.28
SKCM	chr10	73073818	Missense_Mutation	NA	T29I	0.42
SKCM	chr10	73030344	Missense_Mutation	novel	P392L	0.36
SKCM	chr10	73068848	Missense_Mutation	novel	P154L	0.26
SKCM	chr10	73072047	Missense_Mutation	NA	L103F	0.23
SKCM	chr10	73046987	Missense_Mutation	NA	R339C	0.48
SKCM	chr10	73047097	Missense_Mutation	NA	P302L	0.14
SKCM	chr10	73047047	Missense_Mutation	NA	P319S	0.39
SKCM	chr10	73030308	Missense_Mutation	NA	L404P	0.39
SKCM	chr10	73047078	Silent	novel	L308L	0.42
SKCM	chr10	73047071	Missense_Mutation	rs769487606	R311C	0.44
SKCM	chr10	73009888	Missense_Mutation	NA	W485R	0.92	2OG-FeII_Oxy
SKCM	chr10	73046998	Missense_Mutation	NA	P335L	0.46
SKCM	chr10	73068849	Missense_Mutation	NA	P154S	0.1
SKCM	chr10	73046987	Missense_Mutation	NA	R339C	0.3
SKCM	chr10	73008254	Nonsense_Mutation	NA	R525*	0.29
SKCM	chr10	73051250	Splice_Site	novel	X235_splice	0.2
STAD	chr10	73053412	Silent	rs200155008	A214A	0.35
STAD	chr10	73074871	Missense_Mutation	rs368140626	I5V	0.42
STAD	chr10	73053463	Silent	rs201200914	G197G	0.41
STAD	chr10	73045000	Missense_Mutation	NA	H377N	0.21
STAD	chr10	73008220	3'UTR	novel		0.08
STAD	chr10	73045005	Missense_Mutation	rs145054165	T375M	0.14
STAD	chr10	73053507	Missense_Mutation	NA	T183A	0.19
STAD	chr10	73053512	Missense_Mutation	NA	Y181C	0.31
THYM	chr10	73100621	5'Flank	novel		0.25
UCEC	chr10	73030320	Missense_Mutation	NA	R400I	0.25
UCEC	chr10	73008092	3'UTR	novel		0.09
UCEC	chr10	73072049	Missense_Mutation	novel	V102A	0.19
UCEC	chr10	73096811	5'UTR	novel		0.3
UCEC	chr10	73007499	3'UTR	novel		0.37
UCEC	chr10	73008203	3'UTR	novel		0.41
UCEC	chr10	73030332	Missense_Mutation	NA	R396L	0.45
UCEC	chr10	73045045	Nonsense_Mutation	rs201944122	R362*	0.41
UCEC	chr10	73008282	Silent	novel	K515K	0.31
UCEC	chr10	73051086	Silent	rs200368222	Y289Y	0.22
UCEC	chr10	73073782	Missense_Mutation	NA	S41F	0.27
UCEC	chr10	73045045	Nonsense_Mutation	rs201944122	R362*	0.1
UCEC	chr10	73046996	Missense_Mutation	rs553614855	R336C	0.42
UCEC	chr10	73008038	3'UTR	rs201628822		0.57
UCEC	chr10	73043903	Intron	novel		0.1
UCEC	chr10	73007314	3'UTR	novel		0.2
UCEC	chr10	73051121	Frame_Shift_Del	novel	*V278Lfs23**	0.4
UCEC	chr10	73008261	Missense_Mutation	novel	Q522H	0.09
UCEC	chr10	73007280	3'UTR	novel		0.31
UCEC	chr10	73047071	Missense_Mutation	rs769487606	R311C	0.47
UCEC	chr10	73053505	Silent	rs202243570	T183T	0.46
UCEC	chr10	73051131	Missense_Mutation	novel	K274N	0.49
UCEC	chr10	73046986	Missense_Mutation	rs183380808	R339H	0.2
UCEC	chr10	73072166	Missense_Mutation	rs191882218	L63S	0.18
UCEC	chr10	73007511	3'UTR	novel		0.27
UCEC	chr10	73008254	Nonsense_Mutation	NA	R525*	0.36
UCEC	chr10	73046947	Missense_Mutation	novel	V352A	0.35
UCEC	chr10	73051212	Nonsense_Mutation	novel	Y247*	0.29
UCEC	chr10	73072086	Missense_Mutation	rs775076866	R90C	0.38
UCEC	chr10	73030332	Missense_Mutation	rs199926060	R396Q	0.58
UCEC	chr10	73007414	3'UTR	novel		0.14
UCEC	chr10	73047014	Missense_Mutation	NA	D330Y	0.5
UCEC	chr10	73014287	Missense_Mutation	novel	K435N	0.13	2OG-FeII_Oxy
UCEC	chr10	73030320	Missense_Mutation	novel	R400K	0.34
UCEC	chr10	73046987	Missense_Mutation	NA	R339C	0.17
UCEC	chr10	73074840	Missense_Mutation	novel	S15Y	0.39
UCEC	chr10	73008108	3'UTR	novel		0.42
UCEC	chr10	73008254	Nonsense_Mutation	NA	R525*	0.44
UCEC	chr10	73014246	Missense_Mutation	novel	R449I	0.28	2OG-FeII_Oxy
UCEC	chr10	73074868	Silent	novel	L6L	0.47

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.1	0.19593
READ	AMP	0.0485	0.13718
THCA	DEL	0.022	0.011063

Survival Analysis

Cancer	P-value	Q-value
THYM	0.026	Kaplan-Meier Survival Analysis
SARC	0.00088	Kaplan-Meier Survival Analysis
MESO	0.00041	Kaplan-Meier Survival Analysis
HNSC	0.00014	Kaplan-Meier Survival Analysis
SKCM	0.035	Kaplan-Meier Survival Analysis
BRCA	0.0087	Kaplan-Meier Survival Analysis
KIRP	0.00054	Kaplan-Meier Survival Analysis
COAD	0.0054	Kaplan-Meier Survival Analysis
PAAD	0.00046	Kaplan-Meier Survival Analysis
BLCA	0.049	Kaplan-Meier Survival Analysis
CESC	0.0001	Kaplan-Meier Survival Analysis
KICH	0.00044	Kaplan-Meier Survival Analysis
GBM	0.029	Kaplan-Meier Survival Analysis
LGG	0.04	Kaplan-Meier Survival Analysis
THCA	0.039	Kaplan-Meier Survival Analysis
LUAD	0.00092	Kaplan-Meier Survival Analysis
UVM	0.00011	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742