EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000123213 (Gene tree)
Gene ID: 57486
Gene Symbol: NLN
Alias: KIAA1226|AGTBP
Full Name: neurolysin
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 149,530 bases
Position: chr5:65,722,196-65,871,725
Accession: 16058
RBP type: non-canonical RBP
Summary: This gene encodes a member of the metallopeptidase M3 protein family that cleaves neurotensin at the Pro10-Tyr11 bond, leading to the formation of neurotensin(1-10) and neurotensin(11-13). The encoded protein is likely involved in the termination of the neurotensinergic signal in the central nervous system and in the gastrointestinal tract.[provided by RefSeq, Jun 2010]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000502464	NLN-202	8354	-	ENSP00000423214	600 (aa)	-	E9PCB6
ENST00000509935	NLN-207	1106	-	ENSP00000426959	283 (aa)	-	H0YAF7
ENST00000506539	NLN-203	2637	-	-	- (aa)	-	-
ENST00000506677	NLN-204	701	-	-	- (aa)	-	-
ENST00000511299	NLN-208	1658	-	ENSP00000427417	414 (aa)	-	H0YAK4
ENST00000514991	NLN-209	564	-	ENSP00000422822	48 (aa)	-	D6R9Y0
ENST00000506799	NLN-205	2085	-	-	- (aa)	-	-
ENST00000507201	NLN-206	617	-	-	- (aa)	-	-
ENST00000515595	NLN-210	720	-	-	- (aa)	-	-
ENST00000380985	NLN-201	8661	XM_005248559	ENSP00000370372	704 (aa)	XP_005248616	Q9BYT8

Gene Model

Click here to download ENSG00000123213's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04614	Renin-angiotensin system	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000123213	Platelet Function Tests	4.1300000E-007	-
ENSG00000123213	Platelet Function Tests	5.9200000E-007	-
ENSG00000123213	Platelet Function Tests	6.1200000E-007	-
ENSG00000123213	Platelet Function Tests	1.2300000E-006	-
ENSG00000123213	Platelet Function Tests	6.1200000E-007	-
ENSG00000123213	Platelet Function Tests	2.1422700E-005	-
ENSG00000123213	Platelet Function Tests	2.3776500E-005	-
ENSG00000123213	Autistic Disorder	1.0695000E-005	-
ENSG00000123213	amyloid beta-protein (1-42)	6E-7	28247064
ENSG00000123213	Alzheimer Disease	6E-7	28247064
ENSG00000123213	Cerebrospinal Fluid	6E-7	28247064
ENSG00000123213	Trans Fatty Acids	3E-7	25646338
ENSG00000123213	Astigmatism	2E-6	25367360

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000123213	rs6892230	5	65843936	A	Refractive astigmatism	25367360	[1.133-1.349]	1.236	HP_0000483
ENSG00000123213	rs2262994	5	65805135	G	Moyamoya disease	29273593	[NR]	1.31	Orphanet_2573
ENSG00000123213	rs10940051	5	65811762	C	Major depression and alcohol dependence	29071344	[0.21-0.52] unit increase	0.366	EFO_0003761\|EFO_0003829
ENSG00000123213	rs7711329	5	65830201	T	Menstruation quality of life impact (acne)	29855537	[0.11-0.27] unit decrease	0.18926059	EFO_0009366\|EFO_0003894
ENSG00000123213	rs755927998	5	65798162	T	Daytime nap	28604731	[0.21-0.43] unit increase	0.32	EFO_0007828
ENSG00000123213	rs141162384	5	65795351	T	Cerebrospinal fluid AB1-42 levels	28247064	[0.031-0.071] unit increase	0.051	EFO_0004670
ENSG00000123213	rs16894446	5	65841633	T	Trans fatty acid levels	25646338	[0.01-0.023] unit increase	0.0167	EFO_0006825\|EFO_0006821
ENSG00000123213	rs149645408	5	65729582	?	General cognitive ability	29844566	z-score decrease	5.089	EFO_0004337

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000123213's network

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000123213	NLN	99	65.050	ENSG00000172009	THOP1	99	69.048	Homo_sapiens
ENSG00000123213	NLN	99	65.217	ENSMUSG00000004929	Thop1	96	64.688	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004222	metalloendopeptidase activity	21873635.	IBA	Function
GO:0004222	metalloendopeptidase activity	-	TAS	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0005758	mitochondrial intermembrane space	21873635.	IBA	Component
GO:0005886	plasma membrane	-	IEA	Component
GO:0006111	regulation of gluconeogenesis	-	IEA	Process
GO:0006508	proteolysis	21873635.	IBA	Process
GO:0006518	peptide metabolic process	21873635.	IBA	Process
GO:0042277	peptide binding	-	IEA	Function
GO:0046872	metal ion binding	-	IEA	Function
GO:1902809	regulation of skeletal muscle fiber differentiation	-	IEA	Process

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr5	65762967	Silent	novel	R103R	0.44
ACC	chr5	65810134	Missense_Mutation	novel	C604W	0.16
ACC	chr5	65822933	3'UTR	novel		0.23
ACC	chr5	65758709	Missense_Mutation	novel	E62Q	0.34
ACC	chr5	65822869	Missense_Mutation	novel	P690Q	0.24
BLCA	chr5	65788476	Silent	novel	L439L	0.42
BLCA	chr5	65781419	Missense_Mutation	novel	E274Q	0.11
BLCA	chr5	65822819	Silent	NA	G673G	0.29
BLCA	chr5	65758781	Missense_Mutation	novel	E86Q	0.14
BRCA	chr5	65810138	Missense_Mutation	novel	E606K	0.1
BRCA	chr5	65788260	Missense_Mutation	NA	Q367H	0.33
BRCA	chr5	65762962	Missense_Mutation	novel	E102K	0.42
BRCA	chr5	65810056	Missense_Mutation	novel	Q578H	0.07
BRCA	chr5	65758628	Nonsense_Mutation	novel	Q35*	0.04
BRCA	chr5	65823091	3'UTR	novel		0.27
BRCA	chr5	65788260	Silent	novel	Q367Q	0.23
BRCA	chr5	65758814	Missense_Mutation	novel	V97I	0.18
BRCA	chr5	65777531	Silent	novel	Q185Q	0.52
BRCA	chr5	65792598	Silent	NA	D490D	0.41
CESC	chr5	65781358	Silent	NA	K253K	0.11
CESC	chr5	65810065	Missense_Mutation	novel	L581F	0.06
CESC	chr5	65763066	Missense_Mutation	NA	M136I	0.26
CESC	chr5	65810148	Missense_Mutation	novel	G609E	0.21
CESC	chr5	65792713	Intron	novel		0.19
CESC	chr5	65763053	Missense_Mutation	novel	F132C	0.4
CESC	chr5	65810101	Silent	rs750131777	S593S	0.36
CESC	chr5	65822826	Silent	novel	L676L	0.35
CESC	chr5	65788432	Missense_Mutation	NA	D425N	0.19
CESC	chr5	65788210	Missense_Mutation	novel	E351Q	0.42
COAD	chr5	65822862	Missense_Mutation	NA	R688C	0.23
COAD	chr5	65785895	Missense_Mutation	rs151303282	V315I	0.17
COAD	chr5	65758740	Missense_Mutation	NA	Y72C	0.36
COAD	chr5	65810088	Missense_Mutation	NA	H589R	0.38
COAD	chr5	65822908	Missense_Mutation	NA	A703V	0.11
COAD	chr5	65792671	Intron	NA		0.1
COAD	chr5	65812290	Frame_Shift_Del	NA	*G628Dfs29**	0.22
COAD	chr5	65788140	Missense_Mutation	NA	K327N	0.45
COAD	chr5	65792474	Missense_Mutation	NA	A449V	0.18
COAD	chr5	65792632	Missense_Mutation	rs772545743	V502M	0.2
ESCA	chr5	65809642	Missense_Mutation	novel	G552V	0.04
ESCA	chr5	65792476	Missense_Mutation	novel	A450T	0.39
ESCA	chr5	65792656	Splice_Site	novel	X509_splice	0.1
GBM	chr5	65788384	Missense_Mutation	novel	T409S	0.08
GBM	chr5	65788392	Silent	novel	A411A	0.5
GBM	chr5	65788170	Silent	novel	I337I	0.2
GBM	chr5	65780280	Splice_Region	novel	L220L	0.23
HNSC	chr5	65822832	Missense_Mutation	novel	G678C	0.41
HNSC	chr5	65788179	Silent	novel	L340L	0.08
HNSC	chr5	65822912	Silent	rs766466206	P704P	0.2
HNSC	chr5	65809615	Missense_Mutation	rs372513324	R543Q	0.2
HNSC	chr5	65777514	Missense_Mutation	novel	L180V	0.2
HNSC	chr5	65781290	Frame_Shift_Ins	novel	*L231Yfs6**	0.67
HNSC	chr5	65781293	Frame_Shift_Del	novel	*E232Kfs12**	0.67
HNSC	chr5	65758745	Missense_Mutation	novel	A74T	0.05
HNSC	chr5	65758746	Missense_Mutation	novel	A74V	0.06
HNSC	chr5	65763097	Missense_Mutation	novel	V147F	0.09
HNSC	chr5	65758709	Missense_Mutation	novel	E62Q	0.28
KIRP	chr5	65722328	5'UTR	novel		0.43
LGG	chr5	65822836	Missense_Mutation	rs149642804	M679T	0.52
LIHC	chr5	65822936	3'UTR	rs375732776		0.15
LUAD	chr5	65758742	Missense_Mutation	novel	D73H	0.05
LUAD	chr5	65788299	Silent	NA	L380L	0.2
LUAD	chr5	65792658	Splice_Region	novel		0.1
LUAD	chr5	65758566	Splice_Site	NA	X14_splice	0.46
LUAD	chr5	65781342	Missense_Mutation	NA	Y248C	0.53
LUAD	chr5	65785823	Missense_Mutation	novel	A291S	0.14
LUAD	chr5	65788357	Missense_Mutation	novel	L400M	0.58
LUAD	chr5	65810101	Silent	novel	S593S	0.12
LUAD	chr5	65781378	Missense_Mutation	novel	T260S	0.5
LUAD	chr5	65781398	Missense_Mutation	novel	A267P	0.33
LUSC	chr5	65788260	Silent	novel	Q367Q	0.23
LUSC	chr5	65777520	Missense_Mutation	NA	E182Q	0.16
LUSC	chr5	65785858	Silent	rs189259847	F302F	0.37
LUSC	chr5	65788162	Missense_Mutation	NA	E335Q	0.13
LUSC	chr5	65780194	Missense_Mutation	novel	K192E	0.24
LUSC	chr5	65781305	Missense_Mutation	novel	D236N	0.13
OV	chr5	65822831	Silent	rs148323761	D677D	0.27
PRAD	chr5	65781316	Silent	novel	Y239Y	0.17
READ	chr5	65809545	Missense_Mutation	novel	V520M	0.14
READ	chr5	65758825	Missense_Mutation	novel	I100M	0.39
READ	chr5	65810100	Missense_Mutation	rs756611686	S593L	0.5
SARC	chr5	65823153	3'UTR	novel		0.34
SKCM	chr5	65777500	Missense_Mutation	novel	R175K	0.18
SKCM	chr5	65822789	Missense_Mutation	novel	M663I	0.35
SKCM	chr5	65792671	Intron	NA		0.22
SKCM	chr5	65792573	Missense_Mutation	NA	G482V	0.57
SKCM	chr5	65763049	Missense_Mutation	rs769193581	R131C	0.32
SKCM	chr5	65792544	Silent	novel	L472L	0.34
SKCM	chr5	65788312	Missense_Mutation	NA	P385S	0.32
SKCM	chr5	65785912	Splice_Site	NA	X320_splice	0.38
SKCM	chr5	65785805	Missense_Mutation	NA	P285S	0.33
SKCM	chr5	65812339	Missense_Mutation	NA	S643F	0.4
SKCM	chr5	65762981	Missense_Mutation	novel	F108Y	0.13
SKCM	chr5	65777493	Missense_Mutation	novel	G173R	0.24
SKCM	chr5	65792470	Missense_Mutation	novel	H448Y	0.56
SKCM	chr5	65809700	Splice_Region	novel	T571T	0.38
STAD	chr5	65785797	Missense_Mutation	NA	Q282R	0.19
STAD	chr5	65822831	Silent	rs148323761	D677D	0.26
STAD	chr5	65792474	Missense_Mutation	NA	A449V	0.29
STAD	chr5	65781339	Missense_Mutation	NA	H247R	0.09
STAD	chr5	65777468	Silent	NA	R164R	0.36
STAD	chr5	65792485	Missense_Mutation	rs758153412	G453S	0.08
STAD	chr5	65788225	Missense_Mutation	NA	I356V	0.18
STAD	chr5	65822881	Missense_Mutation	rs769012222	A694V	0.27
TGCT	chr5	65822780	Splice_Site	novel	X661_splice	0.07
THYM	chr5	65822789	Missense_Mutation	novel	M663I	0.09
UCEC	chr5	65792541	Silent	novel	A471A	0.16
UCEC	chr5	65792810	Intron	novel		0.47
UCEC	chr5	65785858	Silent	rs189259847	F302F	0.36
UCEC	chr5	65809592	Nonsense_Mutation	novel	W535*	0.29
UCEC	chr5	65809604	Silent	rs774054316	V539V	0.39
UCEC	chr5	65823153	3'UTR	novel		0.44
UCEC	chr5	65812387	Missense_Mutation	rs376588796	P659L	0.36
UCEC	chr5	65792555	Missense_Mutation	novel	F476C	0.25
UCEC	chr5	65792710	Intron	novel		0.16
UCEC	chr5	65777425	Splice_Site	NA	X151_splice	0.09
UCEC	chr5	65810039	Missense_Mutation	NA	L573I	0.08
UCEC	chr5	65758717	Silent	novel	L64L	0.48
UCEC	chr5	65788272	Silent	novel	L371L	0.33
UCEC	chr5	65812387	Missense_Mutation	rs376588796	P659L	0.25
UCEC	chr5	65788223	Missense_Mutation	novel	K355T	0.29
UCEC	chr5	65792970	Intron	novel		0.33
UCEC	chr5	65788275	Silent	novel	K372K	0.35
UCEC	chr5	65788296	Missense_Mutation	novel	F379L	0.44
UCEC	chr5	65823087	3'UTR	novel		0.33
UCEC	chr5	65785858	Silent	rs189259847	F302F	0.26
UCEC	chr5	65780238	Silent	novel	L206L	0.21
UCEC	chr5	65777510	In_Frame_Ins	novel	L178_H179insNT	0.12
UCEC	chr5	65822981	3'UTR	novel		0.16
UCEC	chr5	65823251	3'UTR	novel		0.15
UCEC	chr5	65777420	Splice_Region	novel		0.44
UCEC	chr5	65792783	Intron	novel		0.29
UCEC	chr5	65792773	Intron	NA		0.43
UCEC	chr5	65785830	Missense_Mutation	NA	L293P	0.04
UCEC	chr5	65792671	Intron	NA		0.38
UCEC	chr5	65758596	Missense_Mutation	rs555372750	M24T	0.28
UCEC	chr5	65822981	3'UTR	novel		0.13
UCEC	chr5	65810165	Missense_Mutation	novel	G615C	0.18
UCEC	chr5	65792566	Missense_Mutation	NA	V480L	0.16
UCEC	chr5	65822981	3'UTR	novel		0.11
UCEC	chr5	65777481	Missense_Mutation	NA	S169P	0.47
UCEC	chr5	65781344	Missense_Mutation	novel	F249V	0.58
UCEC	chr5	65823021	3'UTR	novel		0.35

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BRCA	DEL	0.2398	1.1352e-11
CHOL	DEL	0.2222	0.16947
LUSC	DEL	0.6427	0.002071
MESO	DEL	0.1264	0.20184
THCA	DEL	0.002	0.23456

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
STAD	0.039	Kaplan-Meier Survival Analysis
SARC	0.0094	Kaplan-Meier Survival Analysis
MESO	0.00011	Kaplan-Meier Survival Analysis
ACC	0.0093	Kaplan-Meier Survival Analysis
UCS	0.0029	Kaplan-Meier Survival Analysis
HNSC	0.03	Kaplan-Meier Survival Analysis
SKCM	0.01	Kaplan-Meier Survival Analysis
BRCA	0.038	Kaplan-Meier Survival Analysis
COAD	0.0048	Kaplan-Meier Survival Analysis
PAAD	0.0023	Kaplan-Meier Survival Analysis
BLCA	0.012	Kaplan-Meier Survival Analysis
READ	0.0089	Kaplan-Meier Survival Analysis
LIHC	0.0011	Kaplan-Meier Survival Analysis
LGG	0.0028	Kaplan-Meier Survival Analysis
LUAD	0.0025	Kaplan-Meier Survival Analysis
UVM	0.0037	Kaplan-Meier Survival Analysis