EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000123297 (Gene tree)
Gene ID: 10102
Gene Symbol: TSFM
Alias: EF-Tsmt|EF-TS
Full Name: Ts translation elongation factor, mitochondrial
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 25,483 bases
Position: chr12:57,782,589-57,808,071
Accession: 12367
RBP type: canonical RBP
Summary: This gene encodes a mitochondrial translation elongation factor. The encoded protein is an enzyme that catalyzes the exchange of guanine nucleotides on the translation elongation factor Tu during the elongation step of mitchondrial protein translation. Mutations in this gene are associated with combined oxidative phosphorylation deficiency-3 syndrome. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2010]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000388330	EF_TS	PF00889.19	1e-25	1	1
ENSP00000313877	EF_TS	PF00889.19	9.2e-25	1	1
ENSP00000389162	EF_TS	PF00889.19	3.3e-14	1	1
ENSP00000390679	EF_TS	PF00889.19	1.5e-07	1	1
ENSP00000440987	EF_TS	PF00889.19	1.9e-07	1	1
ENSP00000450041	EF_TS	PF00889.19	2.7e-07	1	1
ENSP00000439342	EF_TS	PF00889.19	3e-07	1	1
ENSP00000448575	EF_TS	PF00889.19	3.4e-07	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000550559	TSFM-210	897	-	ENSP00000448575	230 (aa)	-	F8VS27
ENST00000434359	TSFM-203	589	-	ENSP00000390679	140 (aa)	-	C9JG32
ENST00000457189	TSFM-205	689	-	ENSP00000389162	168 (aa)	-	C9JT21
ENST00000454289	TSFM-204	2192	-	ENSP00000388330	325 (aa)	-	P43897
ENST00000548851	TSFM-209	794	-	ENSP00000450041	200 (aa)	-	F8VPA7
ENST00000323833	TSFM-201	1218	-	ENSP00000313877	346 (aa)	-	P43897
ENST00000417094	TSFM-202	558	-	ENSP00000406339	89 (aa)	-	F8WCK2
ENST00000497617	TSFM-206	770	-	-	- (aa)	-	-
ENST00000540550	TSFM-207	1935	-	ENSP00000440987	167 (aa)	-	P43897
ENST00000543727	TSFM-208	651	-	ENSP00000439342	215 (aa)	-	P43897

Gene Model

Click here to download ENSG00000123297's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000123297	rs201202118	12	57788279	A	Multiple sclerosis	24076602		1.13	EFO_0003885
ENSG00000123297	rs143969105	12	57807682	G	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL)	28090653	[1.21-62.08]	8.68	EFO_0004735\|EFO_0007965\|EFO_0000220
ENSG00000123297	rs143969105	12	57807682	G	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL)	28090653	[1.23-66.26]	9.04	EFO_0004735\|EFO_0007965\|EFO_0000220

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000123297's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000123297	TSFM	100	55.952	ENSAPOG00000014844	tsfm	86	52.222	Acanthochromis_polyacanthus
ENSG00000123297	TSFM	100	91.071	ENSAMEG00000005452	TSFM	96	87.859	Ailuropoda_melanoleuca
ENSG00000123297	TSFM	100	58.580	ENSACIG00000001066	tsfm	90	52.281	Amphilophus_citrinellus
ENSG00000123297	TSFM	100	55.357	ENSAOCG00000007132	tsfm	86	52.222	Amphiprion_ocellaris
ENSG00000123297	TSFM	100	56.548	ENSAPEG00000015755	tsfm	86	53.333	Amphiprion_percula
ENSG00000123297	TSFM	100	57.143	ENSATEG00000001497	tsfm	86	53.846	Anabas_testudineus
ENSG00000123297	TSFM	100	70.922	ENSACAG00000013044	TSFM	84	68.978	Anolis_carolinensis
ENSG00000123297	TSFM	100	94.643	ENSANAG00000038019	TSFM	100	93.043	Aotus_nancymaae
ENSG00000123297	TSFM	100	58.580	ENSACLG00000000139	tsfm	86	53.506	Astatotilapia_calliptera
ENSG00000123297	TSFM	100	58.451	ENSAMXG00000001713	tsfm	87	50.549	Astyanax_mexicanus
ENSG00000123297	TSFM	100	91.071	ENSBTAG00000016912	TSFM	85	85.015	Bos_taurus
ENSG00000123297	TSFM	95	40.741	WBGene00010094	tsfm-1	90	32.765	Caenorhabditis_elegans
ENSG00000123297	TSFM	100	94.048	ENSCJAG00000006600	TSFM	100	92.208	Callithrix_jacchus
ENSG00000123297	TSFM	100	87.500	ENSCAFG00000000293	-	89	86.014	Canis_familiaris
ENSG00000123297	TSFM	100	87.500	ENSCAFG00020022844	TSFM	76	80.769	Canis_lupus_dingo
ENSG00000123297	TSFM	100	90.476	ENSCHIG00000013850	TSFM	96	87.540	Capra_hircus
ENSG00000123297	TSFM	83	92.086	ENSTSYG00000028892	TSFM	89	92.308	Carlito_syrichta
ENSG00000123297	TSFM	59	76.166	ENSCAPG00000007733	-	93	76.166	Cavia_aperea
ENSG00000123297	TSFM	100	90.476	ENSCPOG00000037732	TSFM	96	88.254	Cavia_porcellus
ENSG00000123297	TSFM	100	93.571	ENSCCAG00000033254	TSFM	100	92.609	Cebus_capucinus
ENSG00000123297	TSFM	100	94.643	ENSCATG00000016867	TSFM	100	94.348	Cercocebus_atys
ENSG00000123297	TSFM	100	82.738	ENSCLAG00000009226	TSFM	96	80.831	Chinchilla_lanigera
ENSG00000123297	TSFM	100	95.833	ENSCSAG00000004601	TSFM	96	95.847	Chlorocebus_sabaeus
ENSG00000123297	TSFM	85	85.211	ENSCHOG00000002360	TSFM	77	98.246	Choloepus_hoffmanni
ENSG00000123297	TSFM	100	72.781	ENSCPBG00000018147	TSFM	89	70.470	Chrysemys_picta_bellii
ENSG00000123297	TSFM	100	37.324	ENSCING00000001275	-	97	32.209	Ciona_intestinalis
ENSG00000123297	TSFM	100	34.320	ENSCSAVG00000007722	-	99	33.182	Ciona_savignyi
ENSG00000123297	TSFM	97	86.503	ENSCANG00000030298	TSFM	92	96.774	Colobus_angolensis_palliatus
ENSG00000123297	TSFM	100	90.476	ENSCGRG00001023000	TSFM	96	85.942	Cricetulus_griseus_chok1gshd
ENSG00000123297	TSFM	100	90.476	ENSCGRG00000006566	TSFM	96	85.942	Cricetulus_griseus_crigri
ENSG00000123297	TSFM	84	53.191	ENSCSEG00000003376	tsfm	81	50.847	Cynoglossus_semilaevis
ENSG00000123297	TSFM	100	57.447	ENSCVAG00000001340	tsfm	96	49.667	Cyprinodon_variegatus
ENSG00000123297	TSFM	100	59.155	ENSDARG00000060748	tsfm	96	45.075	Danio_rerio
ENSG00000123297	TSFM	100	88.690	ENSDNOG00000049415	TSFM	96	85.623	Dasypus_novemcinctus
ENSG00000123297	TSFM	84	87.943	ENSDORG00000007272	Tsfm	89	89.407	Dipodomys_ordii
ENSG00000123297	TSFM	99	45.652	FBgn0032646	mEFTs	84	38.603	Drosophila_melanogaster
ENSG00000123297	TSFM	100	86.310	ENSETEG00000002686	-	96	83.067	Echinops_telfairi
ENSG00000123297	TSFM	100	88.690	ENSEASG00005007292	TSFM	80	81.957	Equus_asinus_asinus
ENSG00000123297	TSFM	100	89.286	ENSECAG00000010520	TSFM	80	87.713	Equus_caballus
ENSG00000123297	TSFM	100	80.000	ENSEEUG00000004147	-	100	74.737	Erinaceus_europaeus
ENSG00000123297	TSFM	98	59.124	ENSELUG00000015481	tsfm	86	54.815	Esox_lucius
ENSG00000123297	TSFM	100	88.690	ENSFCAG00000023794	TSFM	96	87.540	Felis_catus
ENSG00000123297	TSFM	100	88.690	ENSFDAG00000016548	TSFM	96	86.262	Fukomys_damarensis
ENSG00000123297	TSFM	100	58.580	ENSFHEG00000013458	tsfm	91	52.797	Fundulus_heteroclitus
ENSG00000123297	TSFM	100	52.976	ENSGMOG00000000868	tsfm	92	50.000	Gadus_morhua
ENSG00000123297	TSFM	100	56.805	ENSGAFG00000021764	tsfm	91	51.049	Gambusia_affinis
ENSG00000123297	TSFM	100	54.286	ENSGACG00000000697	tsfm	88	49.814	Gasterosteus_aculeatus
ENSG00000123297	TSFM	100	71.006	ENSGAGG00000020897	TSFM	86	71.918	Gopherus_agassizii
ENSG00000123297	TSFM	100	99.405	ENSGGOG00000001415	TSFM	100	99.077	Gorilla_gorilla
ENSG00000123297	TSFM	100	57.988	ENSHBUG00000021738	tsfm	86	53.137	Haplochromis_burtoni
ENSG00000123297	TSFM	100	90.000	ENSHGLG00000008559	TSFM	96	87.220	Heterocephalus_glaber_female
ENSG00000123297	TSFM	100	90.000	ENSHGLG00100005643	TSFM	96	87.220	Heterocephalus_glaber_male
ENSG00000123297	TSFM	100	55.357	ENSHCOG00000021049	tsfm	92	50.172	Hippocampus_comes
ENSG00000123297	TSFM	79	60.360	ENSHCOG00000019566	-	91	59.231	Hippocampus_comes
ENSG00000123297	TSFM	100	38.095	ENSIPUG00000019836	tsfm	90	38.462	Ictalurus_punctatus
ENSG00000123297	TSFM	100	92.262	ENSSTOG00000001159	TSFM	96	90.415	Ictidomys_tridecemlineatus
ENSG00000123297	TSFM	100	89.286	ENSJJAG00000012907	Tsfm	96	84.665	Jaculus_jaculus
ENSG00000123297	TSFM	100	56.805	ENSKMAG00000018906	tsfm	86	54.044	Kryptolebias_marmoratus
ENSG00000123297	TSFM	100	56.548	ENSLBEG00000019779	tsfm	86	52.222	Labrus_bergylta
ENSG00000123297	TSFM	100	69.643	ENSLACG00000018125	TSFM	96	62.893	Latimeria_chalumnae
ENSG00000123297	TSFM	79	63.964	ENSLOCG00000006608	tsfm	89	42.177	Lepisosteus_oculatus
ENSG00000123297	TSFM	100	89.286	ENSLAFG00000015177	TSFM	96	86.581	Loxodonta_africana
ENSG00000123297	TSFM	100	94.643	ENSMFAG00000036132	TSFM	100	94.348	Macaca_fascicularis
ENSG00000123297	TSFM	100	94.643	ENSMMUG00000005893	TSFM	100	94.000	Macaca_mulatta
ENSG00000123297	TSFM	100	94.643	ENSMNEG00000026351	TSFM	100	94.348	Macaca_nemestrina
ENSG00000123297	TSFM	100	94.048	ENSMLEG00000029811	TSFM	100	93.913	Mandrillus_leucophaeus
ENSG00000123297	TSFM	100	59.763	ENSMAMG00000002230	tsfm	93	53.741	Mastacembelus_armatus
ENSG00000123297	TSFM	100	57.988	ENSMZEG00005008170	tsfm	86	53.137	Maylandia_zebra
ENSG00000123297	TSFM	100	86.905	ENSMAUG00000011705	Tsfm	96	83.706	Mesocricetus_auratus
ENSG00000123297	TSFM	100	90.476	ENSMICG00000003812	TSFM	100	84.500	Microcebus_murinus
ENSG00000123297	TSFM	100	88.690	ENSMOCG00000006104	Tsfm	96	85.942	Microtus_ochrogaster
ENSG00000123297	TSFM	100	55.357	ENSMMOG00000021854	tsfm	90	51.579	Mola_mola
ENSG00000123297	TSFM	99	80.240	ENSMODG00000021351	TSFM	92	73.651	Monodelphis_domestica
ENSG00000123297	TSFM	100	56.548	ENSMALG00000015046	tsfm	86	52.593	Monopterus_albus
ENSG00000123297	TSFM	100	91.667	MGP_CAROLIEiJ_G0015873	Tsfm	96	86.262	Mus_caroli
ENSG00000123297	TSFM	100	92.262	ENSMUSG00000040521	Tsfm	99	83.333	Mus_musculus
ENSG00000123297	TSFM	100	92.857	MGP_PahariEiJ_G0031212	Tsfm	99	84.375	Mus_pahari
ENSG00000123297	TSFM	100	92.262	MGP_SPRETEiJ_G0016699	Tsfm	96	86.901	Mus_spretus
ENSG00000123297	TSFM	100	91.071	ENSMPUG00000002051	TSFM	96	87.460	Mustela_putorius_furo
ENSG00000123297	TSFM	100	88.690	ENSMLUG00000005940	TSFM	96	86.581	Myotis_lucifugus
ENSG00000123297	TSFM	100	90.476	ENSNGAG00000014356	Tsfm	96	86.943	Nannospalax_galili
ENSG00000123297	TSFM	100	57.447	ENSNBRG00000016413	tsfm	86	52.768	Neolamprologus_brichardi
ENSG00000123297	TSFM	100	97.846	ENSNLEG00000017178	TSFM	100	97.846	Nomascus_leucogenys
ENSG00000123297	TSFM	77	79.104	ENSMEUG00000004047	TSFM	69	81.148	Notamacropus_eugenii
ENSG00000123297	TSFM	100	77.249	ENSOPRG00000006670	TSFM	97	79.641	Ochotona_princeps
ENSG00000123297	TSFM	100	89.286	ENSODEG00000001882	TSFM	96	85.304	Octodon_degus
ENSG00000123297	TSFM	100	49.405	ENSONIG00000019100	tsfm	85	48.148	Oreochromis_niloticus
ENSG00000123297	TSFM	100	78.836	ENSOCUG00000012512	TSFM	75	80.878	Oryctolagus_cuniculus
ENSG00000123297	TSFM	100	57.059	ENSORLG00000030201	tsfm	86	52.399	Oryzias_latipes
ENSG00000123297	TSFM	100	57.647	ENSORLG00020004740	tsfm	86	52.399	Oryzias_latipes_hni
ENSG00000123297	TSFM	100	56.471	ENSORLG00015022703	tsfm	87	52.941	Oryzias_latipes_hsok
ENSG00000123297	TSFM	100	55.714	ENSOMEG00000008934	tsfm	89	51.379	Oryzias_melastigma
ENSG00000123297	TSFM	99	91.617	ENSOGAG00000012235	TSFM	96	85.942	Otolemur_garnettii
ENSG00000123297	TSFM	100	91.071	ENSOARG00000005095	TSFM	96	84.404	Ovis_aries
ENSG00000123297	TSFM	100	99.405	ENSPPAG00000043428	TSFM	100	98.769	Pan_paniscus
ENSG00000123297	TSFM	100	88.690	ENSPPRG00000009667	TSFM	96	87.540	Panthera_pardus
ENSG00000123297	TSFM	100	88.690	ENSPTIG00000015290	TSFM	96	88.179	Panthera_tigris_altaica
ENSG00000123297	TSFM	100	99.405	ENSPTRG00000005152	TSFM	100	98.844	Pan_troglodytes
ENSG00000123297	TSFM	100	94.643	ENSPANG00000007866	TSFM	100	94.348	Papio_anubis
ENSG00000123297	TSFM	100	53.901	ENSPKIG00000008495	tsfm	83	51.481	Paramormyrops_kingsleyae
ENSG00000123297	TSFM	64	70.423	ENSPSIG00000015776	TSFM	91	71.144	Pelodiscus_sinensis
ENSG00000123297	TSFM	100	52.663	ENSPMGG00000007022	tsfm	92	47.423	Periophthalmus_magnuspinnatus
ENSG00000123297	TSFM	100	86.310	ENSPEMG00000000414	Tsfm	96	83.387	Peromyscus_maniculatus_bairdii
ENSG00000123297	TSFM	99	80.838	ENSPCIG00000023619	TSFM	96	73.651	Phascolarctos_cinereus
ENSG00000123297	TSFM	98	57.229	ENSPFOG00000010782	tsfm	91	51.399	Poecilia_formosa
ENSG00000123297	TSFM	98	57.831	ENSPLAG00000008105	tsfm	91	52.098	Poecilia_latipinna
ENSG00000123297	TSFM	98	56.627	ENSPMEG00000002567	tsfm	91	51.748	Poecilia_mexicana
ENSG00000123297	TSFM	98	56.024	ENSPREG00000016696	tsfm	91	51.399	Poecilia_reticulata
ENSG00000123297	TSFM	100	98.810	ENSPPYG00000004708	TSFM	85	98.154	Pongo_abelii
ENSG00000123297	TSFM	100	82.123	ENSPCAG00000003789	TSFM	96	82.716	Procavia_capensis
ENSG00000123297	TSFM	100	92.857	ENSPCOG00000021606	TSFM	100	87.500	Propithecus_coquereli
ENSG00000123297	TSFM	100	90.476	ENSPVAG00000012141	TSFM	96	88.179	Pteropus_vampyrus
ENSG00000123297	TSFM	100	57.988	ENSPNYG00000001230	tsfm	86	53.137	Pundamilia_nyererei
ENSG00000123297	TSFM	100	56.338	ENSPNAG00000003241	tsfm	90	50.175	Pygocentrus_nattereri
ENSG00000123297	TSFM	100	88.571	ENSRNOG00000048843	Tsfm	96	78.778	Rattus_norvegicus
ENSG00000123297	TSFM	100	95.833	ENSRBIG00000037278	TSFM	100	95.217	Rhinopithecus_bieti
ENSG00000123297	TSFM	100	95.833	ENSRROG00000031769	TSFM	100	95.652	Rhinopithecus_roxellana
ENSG00000123297	TSFM	97	81.395	ENSSBOG00000021465	TSFM	96	92.208	Saimiri_boliviensis_boliviensis
ENSG00000123297	TSFM	99	81.437	ENSSHAG00000009664	TSFM	96	71.515	Sarcophilus_harrisii
ENSG00000123297	TSFM	100	56.338	ENSSFOG00015014457	tsfm	86	52.941	Scleropages_formosus
ENSG00000123297	TSFM	100	56.548	ENSSMAG00000002467	tsfm	86	52.593	Scophthalmus_maximus
ENSG00000123297	TSFM	100	57.738	ENSSDUG00000006833	tsfm	86	52.222	Seriola_dumerili
ENSG00000123297	TSFM	77	35.115	ENSSLDG00000005996	-	80	35.115	Seriola_lalandi_dorsalis
ENSG00000123297	TSFM	100	58.333	ENSSLDG00000000715	tsfm	85	52.593	Seriola_lalandi_dorsalis
ENSG00000123297	TSFM	63	88.889	ENSSARG00000000785	-	82	71.282	Sorex_araneus
ENSG00000123297	TSFM	100	66.864	ENSSPUG00000006435	TSFM	96	69.030	Sphenodon_punctatus
ENSG00000123297	TSFM	100	56.548	ENSSPAG00000002548	tsfm	86	52.963	Stegastes_partitus
ENSG00000123297	TSFM	100	89.881	ENSSSCG00000037767	TSFM	85	85.015	Sus_scrofa
ENSG00000123297	TSFM	100	60.119	ENSTRUG00000003081	tsfm	87	55.185	Takifugu_rubripes
ENSG00000123297	TSFM	100	59.524	ENSTNIG00000014578	tsfm	91	54.671	Tetraodon_nigroviridis
ENSG00000123297	TSFM	96	84.472	ENSTBEG00000011603	TSFM	97	74.850	Tupaia_belangeri
ENSG00000123297	TSFM	100	89.881	ENSTTRG00000008351	TSFM	95	89.677	Tursiops_truncatus
ENSG00000123297	TSFM	100	89.881	ENSUAMG00000013142	TSFM	96	87.540	Ursus_americanus
ENSG00000123297	TSFM	100	89.881	ENSUMAG00000020123	TSFM	96	87.540	Ursus_maritimus
ENSG00000123297	TSFM	72	92.537	ENSVPAG00000000209	TSFM	68	93.443	Vicugna_pacos
ENSG00000123297	TSFM	100	85.799	ENSVVUG00000016735	TSFM	93	81.973	Vulpes_vulpes
ENSG00000123297	TSFM	100	67.262	ENSXETG00000009653	tsfm	95	64.085	Xenopus_tropicalis
ENSG00000123297	TSFM	100	56.213	ENSXMAG00000018468	tsfm	91	51.049	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0003746	translation elongation factor activity	21873635.	IBA	Function
GO:0005515	protein binding	25910212.	IPI	Function
GO:0005634	nucleus	-	IDA	Component
GO:0005739	mitochondrion	-	IDA	Component
GO:0005759	mitochondrial matrix	21873635.	IBA	Component
GO:0006414	translational elongation	7615523.	TAS	Process
GO:0032784	regulation of DNA-templated transcription, elongation	7615523.	TAS	Process
GO:0070125	mitochondrial translational elongation	21873635.	IBA	Process
GO:0070129	regulation of mitochondrial translation	27677415.	IDA	Process