EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000123600 (Gene tree)
Gene ID: 79828
Gene Symbol: METTL8
Alias: TIP
Full Name: Methyltransferase Like 8
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 117,401 bases
Position: chr2:171,317,402-171,434,802
Accession: 25856
RBP type: non-canonical RBP
Summary: METTL8 (Methyltransferase Like 8) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include methyltransferase activity and histone acetyltransferase activity. An important paralog of this gene is METTL2A.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000462821	METTL8-211	623	-	-	- (aa)	-	-
ENST00000392599	METTL8-202	828	-	ENSP00000376377	226 (aa)	-	B5ME25
ENST00000638989	METTL8-218	876	-	ENSP00000492427	291 (aa)	-	Q9H825
ENST00000438609	METTL8-204	981	-	ENSP00000407180	215 (aa)	-	H7C2P8
ENST00000442541	METTL8-205	563	-	ENSP00000411942	83 (aa)	-	C9J3F1
ENST00000483284	METTL8-216	1880	-	-	- (aa)	-	-
ENST00000375258	METTL8-201	8203	-	ENSP00000364407	379 (aa)	-	E7ETE0
ENST00000447486	METTL8-207	2246	-	ENSP00000409025	241 (aa)	-	Q9H825
ENST00000477130	METTL8-215	445	-	-	- (aa)	-	-
ENST00000464491	METTL8-213	744	-	-	- (aa)	-	-
ENST00000460188	METTL8-209	622	NR_135568	-	- (aa)	-	-
ENST00000470773	METTL8-214	575	-	-	- (aa)	-	-
ENST00000640734	METTL8-219	726	-	ENSP00000491656	241 (aa)	-	Q9H825
ENST00000463392	METTL8-212	697	-	-	- (aa)	-	-
ENST00000442778	METTL8-206	578	-	ENSP00000404646	153 (aa)	-	C9JE69
ENST00000460539	METTL8-210	677	-	-	- (aa)	-	-
ENST00000453846	METTL8-208	558	-	ENSP00000411589	105 (aa)	-	C9J6U8
ENST00000612742	METTL8-217	8132	XM_011511875	ENSP00000480056	407 (aa)	XP_011510177	B3KW44
ENST00000392604	METTL8-203	1697	-	ENSP00000376382	291 (aa)	-	Q9H825

Gene Model

Click here to download ENSG00000123600's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000123600's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005634	nucleus	-	IEA	Component
GO:0005737	cytoplasm	-	IEA	Component
GO:0030488	tRNA methylation	-	IEA	Process
GO:0052735	tRNA (cytosine-3-)-methyltransferase activity	21873635.	IBA	Function

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
28803425	Frameshift Mutations in Repeat Sequences of ANK3, HACD4, TCP10L, TP53BP1, MFN1, LCMT2, RNMT, TRMT6, METTL8 and METTL16 Genes in Colon Cancers.	Pathol Oncol Res	2018 Jul	Yeon SY	doi: 10.1007/s12253-017-0287-2
18434905	The lectin-like domain of tumor necrosis factor-alpha improves alveolar fluid balance in injured isolated rabbit lungs.	Crit Care Med	2008 May	Vadasz I	doi: 10.1097/CCM.0b013e31816f485e.
28551094	A synthetic peptide blocking TRPV1 activation inhibits UV-induced skin responses.	J Dermatol Sci	2017 Oct	Kang SM	doi: 10.1016/j.jdermsci.2017.05.009
31188562	AlkB Homologue 1 Demethylates N3-Methylcytidine in mRNA of Mammals.	ACS Chem Biol	2019 Jul 19	Ma CJ	doi: 10.1021/acschembio.8b01001

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr2	171339278	Missense_Mutation	NA	S171F	0.05
BLCA	chr2	171360458	Missense_Mutation	NA	E67Q	0.55
BLCA	chr2	171330691	Missense_Mutation	rs142842112	S243L	0.11
CESC	chr2	171324075	3'UTR	novel		0.13
CESC	chr2	171339483	Missense_Mutation	novel	D103H	0.19
CESC	chr2	171326087	Intron	NA		0.25
CESC	chr2	171330625	Missense_Mutation	novel	P265H	0.36
CESC	chr2	171339381	Missense_Mutation	novel	A137T	0.3
CESC	chr2	171325867	3'UTR	novel		0.1
CESC	chr2	171360512	Missense_Mutation	NA	D49H	0.3
CHOL	chr2	171331862	Missense_Mutation	novel	S221Y	0.38
CHOL	chr2	171326128	Intron	novel		0.25
COAD	chr2	171324053	3'UTR	novel		0.35
COAD	chr2	171324115	3'UTR	novel		0.38
COAD	chr2	171331820	Missense_Mutation	novel	A235V	0.26
COAD	chr2	171392159	Silent	NA	I9I	0.38
COAD	chr2	171324079	3'UTR	novel		0.31
COAD	chr2	171324196	3'UTR	novel		0.04
COAD	chr2	171339504	Missense_Mutation	NA	H96N	0.15
COAD	chr2	171339430	Missense_Mutation	novel	K120N	0.17
GBM	chr2	171325905	Missense_Mutation	NA	T288A	0.17
HNSC	chr2	171330644	Missense_Mutation	novel	D259N	0.06
HNSC	chr2	171330682	Missense_Mutation	rs768040586	R246K	0.53
HNSC	chr2	171330650	Missense_Mutation	rs772797511	V257I	0.21
KICH	chr2	171325859	3'UTR	novel		0.71
KIRP	chr2	171434790	5'Flank	novel		0.24
KIRP	chr2	171339351	Missense_Mutation	NA	P147S	0.23
KIRP	chr2	171339352	Silent	NA	C146C	0.23
LIHC	chr2	171324045	3'UTR	novel		0.21
LIHC	chr2	171326074	Intron	novel		0.62
LUAD	chr2	171339466	Silent	novel	L108L	0.13
LUAD	chr2	171339343	Silent	NA	V149V	0.13
LUSC	chr2	171339183	Splice_Site	NA	X202_splice	0.19
LUSC	chr2	171360466	Missense_Mutation	rs563180068	K64R	0.41
LUSC	chr2	171360458	Missense_Mutation	NA	E67Q	0.18
OV	chr2	171360499	Missense_Mutation	novel	W53L	0.14
OV	chr2	171339402	In_Frame_Del	NA	S129del	0.28
SARC	chr2	171392187	5'UTR	novel		0.84
SKCM	chr2	171360438	Silent	rs373304784	V73V	0.1
SKCM	chr2	171339456	Missense_Mutation	NA	P112S	0.31
SKCM	chr2	171339307	In_Frame_Del	novel	E152_G161del	0.33
SKCM	chr2	171330619	Missense_Mutation	rs769171322	P267L	0.3
SKCM	chr2	171339257	Missense_Mutation	NA	S178F	0.38
SKCM	chr2	171339488	Missense_Mutation	NA	F101S	0.17
STAD	chr2	171330598	Missense_Mutation	novel	I274T	0.23
STAD	chr2	171331825	Silent	NA	S233S	0.38
STAD	chr2	171360433	Missense_Mutation	NA	L75P	0.37
STAD	chr2	171339329	Frame_Shift_Del	novel	*N154Ifs23**	0.34
THCA	chr2	171339252	Frame_Shift_Del	novel	*F173Nfs22**	0.03
UCEC	chr2	171331855	Missense_Mutation	novel	E223D	0.5
UCEC	chr2	171324307	3'UTR	novel		0.09
UCEC	chr2	171326087	Intron	NA		0.45
UCEC	chr2	171326054	Intron	NA		0.38
UCEC	chr2	171324321	3'UTR	novel		0.04
UCEC	chr2	171339384	Missense_Mutation	novel	S136G	0.08
UCEC	chr2	171325885	3'UTR	novel		0.32
UCEC	chr2	171339240	Frame_Shift_Ins	novel	*G184Rfs11**	0.09
UCEC	chr2	171326108	Intron	novel		0.36
UCEC	chr2	171339247	Missense_Mutation	NA	H181Q	0.2
UCEC	chr2	171324014	3'UTR	novel		0.27
UCEC	chr2	171337492	Missense_Mutation	novel	G206E	0.33
UCEC	chr2	171324355	3'UTR	novel		0.3
UCEC	chr2	171326039	Intron	novel		0.24
UCEC	chr2	171339216	Missense_Mutation	novel	P192S	0.41
UCEC	chr2	171324321	3'UTR	novel		0.06
UCEC	chr2	171325853	3'UTR	novel		0.16
UCEC	chr2	171339480	Missense_Mutation	rs780873428	R104C	0.26
UCEC	chr2	171326124	Intron	novel		0.26
UCEC	chr2	171392198	Splice_Site	NA		0.36
UCEC	chr2	171325860	3'UTR	NA		0.22
UCEC	chr2	171360493	Nonsense_Mutation	novel	*K55Ifs8**	0.04
UCEC	chr2	171360443	Nonsense_Mutation	rs779685244	R72*	0.45
UCEC	chr2	171339419	Nonsense_Mutation	novel	*K124Sfs6**	0.04
UCEC	chr2	171339240	Nonsense_Mutation	novel	G184*	0.42
UCEC	chr2	171324101	3'UTR	novel		0.38

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
PAAD	AMP	0.0652	0.1091
PAAD	DEL	0.0272	0.2014

Survival Analysis

Cancer	P-value	Q-value
THYM	0.012	Kaplan-Meier Survival Analysis
ACC	0.00022	Kaplan-Meier Survival Analysis
ESCA	0.034	Kaplan-Meier Survival Analysis
KIRP	0.0085	Kaplan-Meier Survival Analysis
COAD	0.044	Kaplan-Meier Survival Analysis
PAAD	0.024	Kaplan-Meier Survival Analysis
BLCA	0.0065	Kaplan-Meier Survival Analysis
KICH	0.037	Kaplan-Meier Survival Analysis
UCEC	0.0015	Kaplan-Meier Survival Analysis
LIHC	0.0015	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
THCA	0.0009	Kaplan-Meier Survival Analysis
LUAD	0.0035	Kaplan-Meier Survival Analysis
UVM	0.038	Kaplan-Meier Survival Analysis
OV	0.02	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

PPI

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742