EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000123983 (Gene tree)
Gene ID: 2181
Gene Symbol: ACSL3
Alias: ACS3|PRO2194|FACL3
Full Name: acyl-CoA synthetase long chain family member 3
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 83,706 bases
Position: chr2:222,860,934-222,944,639
Accession: 3570
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes myristate, arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92% identical to that of rat homolog. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000413316	ACSL3-204	650	-	ENSP00000416913	88 (aa)	-	C9JC11
ENST00000535678	ACSL3-209	560	-	ENSP00000438342	95 (aa)	-	F5H062
ENST00000474422	ACSL3-207	760	-	-	- (aa)	-	-
ENST00000421680	ACSL3-205	639	-	-	- (aa)	-	-
ENST00000540115	ACSL3-210	624	-	ENSP00000441643	141 (aa)	-	F5GWH2
ENST00000463813	ACSL3-206	509	-	-	- (aa)	-	-
ENST00000542810	ACSL3-211	428	-	-	- (aa)	-	-
ENST00000495541	ACSL3-208	749	-	-	- (aa)	-	-
ENST00000392066	ACSL3-202	3147	-	ENSP00000375918	720 (aa)	-	O95573
ENST00000407441	ACSL3-203	538	-	ENSP00000385157	18 (aa)	-	H7BYZ7
ENST00000357430	ACSL3-201	5679	-	ENSP00000350012	720 (aa)	-	O95573

Gene Model

Click here to download ENSG00000123983's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00061	Fatty acid biosynthesis	KEGG
hsa00071	Fatty acid degradation	KEGG
hsa01100	Metabolic pathways	KEGG
hsa01212	Fatty acid metabolism	KEGG
hsa03320	PPAR signaling pathway	KEGG
hsa04146	Peroxisome	KEGG
hsa04216	Ferroptosis	KEGG
hsa04714	Thermogenesis	KEGG
hsa04920	Adipocytokine signaling pathway	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000123983	Arteries	2.4900000E-005	-
ENSG00000123983	Arteries	3.2540000E-006	-
ENSG00000123983	Arteries	2.4900000E-005	-
ENSG00000123983	Leukocyte Count	5.6880000E-005	-
ENSG00000123983	Leukocyte Count	7.8060000E-005	-
ENSG00000123983	Leukocyte Count	9.3500000E-005	-
ENSG00000123983	Influenza A Virus, H1N1 Subtype	2E-8	26379185

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000123983	rs34626661	2	222924591	?	Mild influenza (H1N1) infection	26379185			EFO_1001488

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000123983's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000123983	ACSL3	100	92.917	ENSMUSG00000032883	Acsl3	100	94.190	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001676	long-chain fatty acid metabolic process	-	IEA	Process
GO:0004467	long-chain fatty acid-CoA ligase activity	20219900.	IMP	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005741	mitochondrial outer membrane	-	IEA	Component
GO:0005778	peroxisomal membrane	-	IEA	Component
GO:0005783	endoplasmic reticulum	14741744.20605918.	IDA	Component
GO:0005789	endoplasmic reticulum membrane	-	TAS	Component
GO:0005794	Golgi apparatus	20605918.	IDA	Component
GO:0005811	lipid droplet	14741744.21498505.	IDA	Component
GO:0006633	fatty acid biosynthetic process	-	IEA	Process
GO:0007420	brain development	-	IEA	Process
GO:0007584	response to nutrient	-	IEA	Process
GO:0014070	response to organic cyclic compound	-	IEA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016021	integral component of membrane	-	IEA	Component
GO:0019901	protein kinase binding	20605918.	IPI	Function
GO:0019904	protein domain specific binding	20605918.	IPI	Function
GO:0034379	very-low-density lipoprotein particle assembly	18003621.	IMP	Process
GO:0035338	long-chain fatty-acyl-CoA biosynthetic process	-	TAS	Process
GO:0042998	positive regulation of Golgi to plasma membrane protein transport	20605918.	IMP	Process
GO:0044539	long-chain fatty acid import	20219900.	IDA	Process
GO:0048471	perinuclear region of cytoplasm	14741744.20605918.	IDA	Component
GO:0051047	positive regulation of secretion	18003621.	IMP	Process
GO:0102391	decanoate-CoA ligase activity	-	IEA	Function
GO:2001247	positive regulation of phosphatidylcholine biosynthetic process	18003621.	IMP	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
27477280	Fatty Acid Oxidation Mediated by Acyl-CoA Synthetase Long Chain 3 Is Required for Mutant KRAS Lung Tumorigenesis.	Cell Rep	2016 Aug 9	Padanad MS	doi: 10.1016/j.celrep.2016.07.009
15556626	Vitamin D3 inhibits fatty acid synthase expression by stimulating the expression of long-chain fatty-acid-CoA ligase 3 in prostate cancer cells.	FEBS Lett	2004 Nov 19	Qiao S	-
28771887	ACSL3 promotes intratumoral steroidogenesis in prostate cancer cells.	Cancer Sci	2017 Oct	Migita T	doi: 10.1111/cas.13339

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr2	222918119	Silent	novel	I210I	0.16
ACC	chr2	222909112	Nonsense_Mutation	novel	E114*	0.26
ACC	chr2	222924525	Missense_Mutation	novel	L408V	0.22
BLCA	chr2	222933228	Missense_Mutation	novel	A599T	0.34
BLCA	chr2	222930665	Missense_Mutation	novel	L529V	0.3
BRCA	chr2	222921428	Splice_Region	novel	L318L	0.06
BRCA	chr2	222941500	Missense_Mutation	NA	S670N	0.28
BRCA	chr2	222908815	Missense_Mutation	NA	K15E	0.37
CESC	chr2	222924516	Nonsense_Mutation	NA	Q405*	0.22
CESC	chr2	222923079	Missense_Mutation	NA	S361C	0.41
CESC	chr2	222924461	Silent	novel	I386I	0.79
CHOL	chr2	222928888	Missense_Mutation	novel	G498R	0.1
COAD	chr2	222909136	Missense_Mutation	NA	K122Q	0.4
COAD	chr2	222923084	Missense_Mutation	NA	K363Q	0.45
COAD	chr2	222909089	Missense_Mutation	NA	G106E	0.23
COAD	chr2	222908933	Missense_Mutation	NA	R54Q	0.3
COAD	chr2	222934655	Missense_Mutation	NA	V658A	0.05
COAD	chr2	222934560	Silent	rs781721691	V626V	0.1
COAD	chr2	222941533	Missense_Mutation	NA	R681H	0.3
COAD	chr2	222924519	Missense_Mutation	rs145813997	R406C	0.03
DLBC	chr2	222923097	Missense_Mutation	novel	G367E	0.23
ESCA	chr2	222908804	Missense_Mutation	novel	T11I	0.24
ESCA	chr2	222927104	Missense_Mutation	novel	Q460H	0.51
GBM	chr2	222916481	Missense_Mutation	NA	M181V	0.45
GBM	chr2	222916376	Missense_Mutation	novel	N146D	0.13
GBM	chr2	222934592	Missense_Mutation	rs531866665	R637Q	0.34
GBM	chr2	222930720	Missense_Mutation	novel	K547T	0.12
HNSC	chr2	222927097	Missense_Mutation	novel	T458N	0.11
HNSC	chr2	222908853	Missense_Mutation	novel	H27Q	0.33
HNSC	chr2	222928919	Frame_Shift_Ins	novel	*N510Kfs9**	0.33
KIRC	chr2	222930737	Missense_Mutation	NA	D553N	0.19
LGG	chr2	222923147	Missense_Mutation	NA	P384S	0.46
LGG	chr2	222941577	Missense_Mutation	novel	D696Y	0.11
LIHC	chr2	222930747	Missense_Mutation	novel	G556V	0.33
LIHC	chr2	222916485	Missense_Mutation	novel	Y182C	0.37
LUAD	chr2	222933273	Missense_Mutation	novel	A614S	0.06
LUAD	chr2	222921423	Missense_Mutation	novel	E317K	0.2
LUAD	chr2	222941657	3'UTR	novel		0.16
LUAD	chr2	222921310	Nonsense_Mutation	NA	S279*	0.42
LUAD	chr2	222930735	Missense_Mutation	NA	E552A	0.39
LUSC	chr2	222927066	Missense_Mutation	NA	L448V	0.59
LUSC	chr2	222927138	Missense_Mutation	novel	G472C	0.28
LUSC	chr2	222927138	Missense_Mutation	novel	G472C	0.1
LUSC	chr2	222909118	Missense_Mutation	NA	E116Q	0.27
OV	chr2	222916364	Missense_Mutation	novel	V142I	0.23
OV	chr2	222934655	Missense_Mutation	NA	V658A	0.18
OV	chr2	222916390	Silent	novel	G150G	0.1
OV	chr2	222916420	Silent	novel	T160T	0.05
PAAD	chr2	222908908	Missense_Mutation	novel	E46K	0.16
PAAD	chr2	222919092	Missense_Mutation	rs376738660	R232Q	0.23
PAAD	chr2	222921402	Missense_Mutation	novel	G310W	0.24
READ	chr2	222930777	Missense_Mutation	NA	G566V	0.12
READ	chr2	222918147	Missense_Mutation	novel	K220Q	0.13
READ	chr2	222919102	Silent	NA	I235I	0.22
READ	chr2	222908763	5'UTR	novel		0.52
READ	chr2	222941770	3'UTR	novel		0.44
READ	chr2	222941880	3'UTR	novel		0.45
SARC	chr2	222941608	Missense_Mutation	novel	K706R	0.31
SKCM	chr2	222908891	Missense_Mutation	rs758966790	P40L	0.06
SKCM	chr2	222930676	Silent	NA	G532G	0.35
SKCM	chr2	222941532	Missense_Mutation	rs776538313	R681C	0.36
SKCM	chr2	222933168	Missense_Mutation	NA	R579C	0.47
SKCM	chr2	222934618	Missense_Mutation	NA	E646K	0.47
SKCM	chr2	222916384	Silent	novel	G148G	0.44
SKCM	chr2	222916426	Silent	rs377468217	I162I	0.48
SKCM	chr2	222921304	Missense_Mutation	NA	L277S	0.47
SKCM	chr2	222941532	Missense_Mutation	rs776538313	R681C	0.35
SKCM	chr2	222941532	Missense_Mutation	rs776538313	R681C	0.35
STAD	chr2	222919204	Splice_Site	novel	X269_splice	0.27
STAD	chr2	222908839	Missense_Mutation	NA	L23I	0.04
STAD	chr2	222908738	5'UTR	rs748620640		0.18
STAD	chr2	222927036	Nonsense_Mutation	NA	R438*	0.67
STAD	chr2	222919069	Silent	NA	I224I	0.35
STAD	chr2	222927100	Missense_Mutation	rs756484315	T459M	0.29
STAD	chr2	222930701	Frame_Shift_Del	novel	*N542Mfs33**	0.11
STAD	chr2	222919092	Missense_Mutation	rs376738660	R232Q	0.22
STAD	chr2	222927017	Splice_Region	NA	S431S	0.27
STAD	chr2	222908898	Frame_Shift_Del	novel	*F44Sfs17**	0.18
STAD	chr2	222908898	Nonsense_Mutation	NA	Y42*	0.25
THCA	chr2	222941739	3'UTR	novel		0.12
THCA	chr2	222941741	3'UTR	novel		0.06
UCEC	chr2	222919092	Missense_Mutation	rs376738660	R232Q	0.41
UCEC	chr2	222918122	Silent	novel	I211I	0.36
UCEC	chr2	222941650	Missense_Mutation	novel	K720T	0.55
UCEC	chr2	222942245	3'UTR	novel		0.07
UCEC	chr2	222909089	Missense_Mutation	NA	G106E	0.4
UCEC	chr2	222916497	Splice_Site	rs200677606	X186_splice	0.49
UCEC	chr2	222924559	Missense_Mutation	rs781374154	Q419R	0.34
UCEC	chr2	222933268	Missense_Mutation	novel	A612V	0.08
UCEC	chr2	222919085	Missense_Mutation	rs764207762	R230C	0.38
UCEC	chr2	222934641	Silent	novel	E653E	0.04
UCEC	chr2	222930805	Missense_Mutation	novel	K575N	0.39
UCEC	chr2	222923149	Splice_Region	rs757265756	P384P	0.36
UCEC	chr2	222941900	3'UTR	novel		0.38
UCEC	chr2	222919145	Missense_Mutation	NA	G250S	0.25
UCEC	chr2	222927106	Missense_Mutation	NA	R461Q	0.26
UCEC	chr2	222909138	Missense_Mutation	NA	K122N	0.29
UCEC	chr2	222924469	Missense_Mutation	novel	R389Q	0.07
UCEC	chr2	222908933	Missense_Mutation	NA	R54Q	0.53
UCEC	chr2	222942190	3'UTR	rs758198666		0.44
UCEC	chr2	222909059	Missense_Mutation	novel	K96T	0.36
UCEC	chr2	222909134	Frame_Shift_Ins	novel	*I123Nfs3**	0.38
UCEC	chr2	222927106	Missense_Mutation	NA	R461Q	0.39
UCEC	chr2	222933281	Splice_Site	novel	X616_splice	0.16
UCEC	chr2	222941765	3'UTR	novel		0.18
UCEC	chr2	222941767	3'UTR	novel		0.2
UCEC	chr2	222918102	Missense_Mutation	rs774856919	T205A	0.47
UCEC	chr2	222927171	Missense_Mutation	novel	A483S	0.09
UCEC	chr2	222933239	Missense_Mutation	novel	K602N	0.23
UCEC	chr2	222934651	Nonsense_Mutation	novel	E657*	0.15
UCEC	chr2	222942149	3'UTR	novel		0.47
UCEC	chr2	222941919	3'UTR	novel		0.5
UCEC	chr2	222941764	3'UTR	novel		0.13
UCEC	chr2	222934592	Missense_Mutation	rs531866665	R637Q	0.49
UCEC	chr2	222922794	Missense_Mutation	rs139999422	R348H	0.32
UCEC	chr2	222923090	Frame_Shift_Del	novel	*G367Efs9**	0.11
UCEC	chr2	222941813	3'UTR	novel		0.29
UCEC	chr2	222942056	3'UTR	novel		0.33
UCEC	chr2	222934592	Missense_Mutation	rs531866665	R637Q	0.32
UCEC	chr2	222922794	Missense_Mutation	rs139999422	R348H	0.35
UCEC	chr2	222927079	Missense_Mutation	novel	G452D	0.23
UCEC	chr2	222922794	Missense_Mutation	rs139999422	R348H	0.27
UCEC	chr2	222934627	Missense_Mutation	novel	C649R	0.26
UCEC	chr2	222927048	Frame_Shift_Del	novel	*G443Efs21**	0.31
UCEC	chr2	222909035	Missense_Mutation	NA	L88S	0.3
UCEC	chr2	222930730	Missense_Mutation	novel	F550L	0.06
UCEC	chr2	222921395	Silent	NA	G307G	0.31
UCEC	chr2	222908747	5'UTR	novel		0.26
UCEC	chr2	222909138	Missense_Mutation	NA	K122N	0.36
UCEC	chr2	222941900	3'UTR	novel		0.13
UCEC	chr2	222908933	Missense_Mutation	NA	R54Q	0.06
UCEC	chr2	222927100	Missense_Mutation	rs756484315	T459M	0.15
UCEC	chr2	222942246	3'UTR	novel		0.32
UCEC	chr2	222922754	Nonsense_Mutation	novel	E335*	0.29
UCEC	chr2	222923084	Missense_Mutation	novel	K363E	0.44
UCEC	chr2	222941765	3'UTR	novel		0.14
UCEC	chr2	222941766	3'UTR	novel		0.14
UCEC	chr2	222909118	Missense_Mutation	novel	E116K	0.44

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
HNSC	DEL	0.2241	1.278e-25
KIRP	DEL	0.0382	5.174e-05
LUSC	DEL	0.2435	1.3904e-19
MESO	DEL	0.1149	0.014499
PAAD	AMP	0.0707	0.1091
PAAD	DEL	0.0326	0.2014
TGCT	DEL	0.0533	0.062762
THCA	DEL	0.024	0.040844
THYM	DEL	0.0244	0.10691

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00057	Kaplan-Meier Survival Analysis
HNSC	0.039	Kaplan-Meier Survival Analysis
SKCM	0.019	Kaplan-Meier Survival Analysis
LAML	0.0033	Kaplan-Meier Survival Analysis
UCEC	0.013	Kaplan-Meier Survival Analysis
LIHC	0.0006	Kaplan-Meier Survival Analysis
LGG	0.0022	Kaplan-Meier Survival Analysis
LUAD	0.00022	Kaplan-Meier Survival Analysis
UVM	0.013	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742