EuRBPDB

Description

Ensembl ID: ENSG00000124160 (Gene tree)
Gene ID: 57727
Gene Symbol: NCOA5
Alias: bA465L10.6|CIA
Full Name: nuclear receptor coactivator 5
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 28,968 bases
Position: chr20:46,060,985-46,089,952
Accession: 15909
RBP type: non-canonical RBP
Summary: This gene encodes a coregulator for the alpha and beta estrogen receptors and the orphan nuclear receptor NR1D2. The protein localizes to the nucleus, and is thought to have both coactivator and corepressor functions. Its interaction with nuclear receptors is independent of the AF2 domain on the receptors, which is known to regulate interaction with other coreceptors. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2017]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
23452377	CpG oligonucleotides bind TLR9 and RRM-containing proteins in Atlantic salmon (Salmo salar).	BMC Immunol	2013 Mar 1	Iliev DB	doi: 10.1186/1471-2172-14-12.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000290231	NCOA5-201	3220	-	ENSP00000290231	579 (aa)	-	Q9HCD5
ENST00000372291	NCOA5-202	727	-	ENSP00000361365	104 (aa)	-	Q5JY17

Gene Model

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000124160	Multiple Sclerosis	5E-10	21833088

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000124160	rs2425752	20	46073481	A	Multiple sclerosis	21833088	[1.1-1.13]	1.11	EFO_0003885
ENSG00000124160	rs6074013	20	46080900		Depressed affect	29942085	[0.0095-0.0186] unit increase	0.01402	EFO_0003761\|EFO_0004247
ENSG00000124160	rs2425752	20	46073481	T	Hodgkin's lymphoma	30194254	[1.10-1.21]	1.15	EFO_0000183
ENSG00000124160	rs2425752	20	46073481	T	Neuroticism	29942085	z score increase	7.212	EFO_0007660
ENSG00000124160	rs6074012	20	46071527	T	Neuroticism	29942085	z score increase	5.915	EFO_0007660
ENSG00000124160	rs6074015	20	46083536	?	Red blood cell count	30595370			EFO_0004305
ENSG00000124160	rs2425752	20	46073481	?	Neuroticism	30595370			EFO_0007660

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000124160	NCOA5	88	53.846	ENSDARG00000016345	ncoa5	97	47.419	Danio_rerio
ENSG00000124160	NCOA5	100	95.192	ENSMUSG00000039804	Ncoa5	100	94.118	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003682	chromatin binding	-	IEA	Function
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0005515	protein binding	11113208.	IPI	Function
GO:0005615	extracellular space	22664934.	HDA	Component
GO:0005634	nucleus	-	IDA	Component
GO:0015629	actin cytoskeleton	-	IDA	Component
GO:0042593	glucose homeostasis	-	IEA	Process
GO:0046627	negative regulation of insulin receptor signaling pathway	-	IEA	Process