EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000124164 (Gene tree)
Gene ID: 9217
Gene Symbol: VAPB
Alias: VAP-B|VAP-C|ALS8
Full Name: VAMP associated protein B and C
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 61,983 bases
Position: chr20:58,389,119-58,451,101
Accession: 12649
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is a type IV membrane protein found in plasma and intracellular vesicle membranes. The encoded protein is found as a homodimer and as a heterodimer with VAPA. This protein also can interact with VAMP1 and VAMP2 and may be involved in vesicle trafficking. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
25450593	Crystal structure of the VapBC-15 complex from Mycobacterium tuberculosis reveals a two-metal ion dependent PIN-domain ribonuclease and a variable mode of toxin-antitoxin assembly.	J Struct Biol	2014 Dec	Das U	doi: 10.1016/j.jsb.2014.10.002

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000265619	VAPB-201	3596	-	-	- (aa)	-	-
ENST00000475243	VAPB-204	7936	-	ENSP00000417175	243 (aa)	-	O95292
ENST00000395802	VAPB-202	1834	-	ENSP00000379147	99 (aa)	-	O95292
ENST00000476395	VAPB-205	3583	-	-	- (aa)	-	-
ENST00000520497	VAPB-206	937	-	ENSP00000430426	71 (aa)	-	E5RK64
ENST00000463370	VAPB-203	2393	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000124164's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04979	Cholesterol metabolism	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000124164	Cholesterol, HDL	1.77870314819151E-5	17903299
ENSG00000124164	Cholesterol, LDL	8.38922377239488E-5	17903299
ENSG00000124164	Platelet Function Tests	2.1323100E-005	-
ENSG00000124164	Platelet Function Tests	1.9742982E-006	-
ENSG00000124164	Platelet Function Tests	3.8701141E-006	-
ENSG00000124164	Platelet Function Tests	1.6652300E-005	-
ENSG00000124164	Platelet Function Tests	6.5525554E-006	-
ENSG00000124164	Platelet Function Tests	1.5068100E-005	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000124164's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000124164	VAPB	99	97.143	ENSMUSG00000054455	Vapb	100	90.123	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000139	Golgi membrane	-	IEA	Component
GO:0005515	protein binding	9920726.16227268.18160438.18555774.19289470.21976701.22131369.23736259.25616068.25910212.26496610.28377464.	IPI	Function
GO:0005737	cytoplasm	25468996.	IDA	Component
GO:0005783	endoplasmic reticulum	15372378.16891305.18713837.	IDA	Component
GO:0005789	endoplasmic reticulum membrane	16227268.	IDA	Component
GO:0005789	endoplasmic reticulum membrane	-	TAS	Component
GO:0005794	Golgi apparatus	16227268.	IDA	Component
GO:0006874	cellular calcium ion homeostasis	22131369.	IMP	Process
GO:0006888	ER to Golgi vesicle-mediated transport	18713837.	IMP	Process
GO:0007029	endoplasmic reticulum organization	18713837.	IMP	Process
GO:0008017	microtubule binding	18713837.	IDA	Function
GO:0016021	integral component of membrane	-	IEA	Component
GO:0019048	modulation by virus of host morphology or physiology	16227268.	IDA	Process
GO:0019899	enzyme binding	17540579.	IPI	Function
GO:0030148	sphingolipid biosynthetic process	-	TAS	Process
GO:0030968	endoplasmic reticulum unfolded protein response	16891305.	IMP	Process
GO:0033149	FFAT motif binding	18713837.	IMP	Function
GO:0033149	FFAT motif binding	24105263.	IPI	Function
GO:0036498	IRE1-mediated unfolded protein response	20940299.	IDA	Process
GO:0042803	protein homodimerization activity	9920726.16227268.17540579.	IPI	Function
GO:0045070	positive regulation of viral genome replication	16227268.	IMP	Process
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0046982	protein heterodimerization activity	9920726.16227268.	IPI	Function
GO:0048487	beta-tubulin binding	17540579.	IDA	Function
GO:0070971	endoplasmic reticulum exit site	18713837.	IDA	Component
GO:0090114	COPII-coated vesicle budding	18713837.	IMP	Process