EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000124177 (Gene tree)
Gene ID: 84181
Gene Symbol: CHD6
Alias: KIAA1335|FLJ22369|dJ620E11.1|CHD5|RIGB
Full Name: chromodomain helicase DNA binding protein 6
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 216,394 bases
Position: chr20:41,402,101-41,618,494
Accession: 19057
RBP type: canonical RBP
Summary: This gene encodes a member of the SNF2/RAD54 helicase protein family. The encoded protein contains two chromodomains, a helicase domain, and an ATPase domain. Several multi-subunit protein complexes remodel chromatin to allow patterns of cell type-specific gene expression, and the encoded protein is thought to be a core member of one or more of these chromatin remodeling complexes. The encoded protein may function as a transcriptional repressor and is involved in the cellular repression of influenza virus replication. [provided by RefSeq, Jul 2013]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000362330	ResIII	PF04851.15	2.8e-07	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
20631145	Interaction of the papillomavirus E8--E2C protein with the cellular CHD6 protein contributes to transcriptional repression.	J Virol	2010 Sep	Fertey J	doi: 10.1128/JVI.00678-10

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000373233	CHD6-203	10818	XM_005260573	ENSP00000362330	2715 (aa)	XP_005260630	Q8TD26
ENST00000482596	CHD6-209	599	-	-	- (aa)	-	-
ENST00000373222	CHD6-202	2477	-	ENSP00000362319	373 (aa)	-	Q8TD26
ENST00000309279	CHD6-201	1635	-	ENSP00000308684	488 (aa)	-	C9JFU2
ENST00000480022	CHD6-208	2829	-	-	- (aa)	-	-
ENST00000440697	CHD6-205	1635	-	ENSP00000404637	525 (aa)	-	H7C294
ENST00000470470	CHD6-206	1349	-	-	- (aa)	-	-
ENST00000440647	CHD6-204	536	-	ENSP00000392503	149 (aa)	-	A0A075B6P4
ENST00000476641	CHD6-207	862	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000124177's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000124177	Cardiovascular System	1.7490000E-005	-
ENSG00000124177	Estradiol	9.2880000E-005	-
ENSG00000124177	Stomach Neoplasms	7E-6	26098866
ENSG00000124177	Memory	7E-6	25648963
ENSG00000124177	Neuropsychological Tests	7E-6	25648963
ENSG00000124177	Memory	7E-6	25648963
ENSG00000124177	Neuropsychological Tests	7E-6	25648963
ENSG00000124177	Hippocampus	8E-6	22745009

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000124177	rs1010304	20	41473007	A	Verbal declarative memory	25648963			EFO_0006805\|EFO_0004874
ENSG00000124177	rs6129846	20	41478674	C	Verbal declarative memory	25648963			EFO_0006805\|EFO_0004874
ENSG00000124177	rs55864139	20	41420939	A	Gastric adenocarcinoma (histologically verified)	26098866	[1.9-5.11]	3.12	EFO_0000503
ENSG00000124177	rs13037749	20	41435919	A	Hippocampal atrophy	22745009			EFO_0005039
ENSG00000124177	rs117629411	20	41462727	?	Reaction time	29844566	[0.0045-0.0112] unit decrease	0.007845	EFO_0008393
ENSG00000124177	rs79122751	20	41569174	?	Reaction time	29844566	[0.0044-0.0113] unit decrease	0.0078518	EFO_0008393
ENSG00000124177	rs6029691	20	41465724	C	Refractive astigmatism	30306274	[0.01-0.022] dioptres decrease	0.016	HP_0000483

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000124177's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000124177	CHD6	99	82.239	ENSAPOG00000013736	chd6	64	75.963	Acanthochromis_polyacanthus
ENSG00000124177	CHD6	99	99.660	ENSAMEG00000009496	CHD6	100	91.584	Ailuropoda_melanoleuca
ENSG00000124177	CHD6	99	81.853	ENSATEG00000005608	chd6	62	77.464	Anabas_testudineus
ENSG00000124177	CHD6	99	93.411	ENSAPLG00000015592	CHD6	100	72.442	Anas_platyrhynchos
ENSG00000124177	CHD6	98	79.130	ENSACAG00000006842	CHD6	99	67.931	Anolis_carolinensis
ENSG00000124177	CHD6	100	99.329	ENSANAG00000037548	CHD6	100	96.944	Aotus_nancymaae
ENSG00000124177	CHD6	99	82.946	ENSAMXG00000009576	chd6	77	69.547	Astyanax_mexicanus
ENSG00000124177	CHD6	99	100.000	ENSBTAG00000005733	CHD6	100	88.436	Bos_taurus
ENSG00000124177	CHD6	99	99.660	ENSCJAG00000017920	CHD6	100	96.797	Callithrix_jacchus
ENSG00000124177	CHD6	99	99.660	ENSCAFG00000009236	CHD6	100	91.621	Canis_familiaris
ENSG00000124177	CHD6	99	99.660	ENSCAFG00020012906	CHD6	99	97.578	Canis_lupus_dingo
ENSG00000124177	CHD6	99	100.000	ENSCHIG00000017606	CHD6	100	88.473	Capra_hircus
ENSG00000124177	CHD6	78	100.000	ENSTSYG00000014635	CHD6	100	93.023	Carlito_syrichta
ENSG00000124177	CHD6	99	100.000	ENSCPOG00000015641	CHD6	100	91.584	Cavia_porcellus
ENSG00000124177	CHD6	100	99.329	ENSCCAG00000036828	CHD6	100	97.202	Cebus_capucinus
ENSG00000124177	CHD6	100	100.000	ENSCATG00000039248	CHD6	100	97.865	Cercocebus_atys
ENSG00000124177	CHD6	99	99.660	ENSCLAG00000013743	CHD6	100	91.529	Chinchilla_lanigera
ENSG00000124177	CHD6	100	100.000	ENSCSAG00000013997	CHD6	100	98.233	Chlorocebus_sabaeus
ENSG00000124177	CHD6	99	95.614	ENSCHOG00000012647	CHD6	95	89.789	Choloepus_hoffmanni
ENSG00000124177	CHD6	99	93.798	ENSCPBG00000019382	CHD6	99	74.012	Chrysemys_picta_bellii
ENSG00000124177	CHD6	100	100.000	ENSCANG00000043435	CHD6	100	98.196	Colobus_angolensis_palliatus
ENSG00000124177	CHD6	99	97.279	ENSCGRG00001002694	Chd6	100	89.563	Cricetulus_griseus_chok1gshd
ENSG00000124177	CHD6	93	86.331	ENSCGRG00000006749	-	99	94.444	Cricetulus_griseus_crigri
ENSG00000124177	CHD6	99	84.496	ENSDARG00000017244	chd6	79	73.678	Danio_rerio
ENSG00000124177	CHD6	99	99.225	ENSDNOG00000004176	CHD6	99	90.859	Dasypus_novemcinctus
ENSG00000124177	CHD6	99	100.000	ENSEASG00005023433	CHD6	95	97.876	Equus_asinus_asinus
ENSG00000124177	CHD6	99	100.000	ENSECAG00000011761	CHD6	100	92.828	Equus_caballus
ENSG00000124177	CHD6	99	81.008	ENSELUG00000012309	chd6	92	79.664	Esox_lucius
ENSG00000124177	CHD6	99	99.660	ENSFCAG00000003572	CHD6	100	91.915	Felis_catus
ENSG00000124177	CHD6	99	93.411	ENSFALG00000012563	CHD6	98	71.366	Ficedula_albicollis
ENSG00000124177	CHD6	99	98.837	ENSFDAG00000013791	CHD6	99	91.704	Fukomys_damarensis
ENSG00000124177	CHD6	92	78.603	ENSGMOG00000011715	chd6	85	69.693	Gadus_morhua
ENSG00000124177	CHD6	90	78.603	ENSGACG00000000037	chd6	99	54.617	Gasterosteus_aculeatus
ENSG00000124177	CHD6	53	93.411	ENSGAGG00000007475	-	79	94.169	Gopherus_agassizii
ENSG00000124177	CHD6	100	100.000	ENSGGOG00000013123	CHD6	100	99.595	Gorilla_gorilla
ENSG00000124177	CHD6	99	80.695	ENSHBUG00000014701	chd6	65	73.482	Haplochromis_burtoni
ENSG00000124177	CHD6	99	98.980	ENSHGLG00000004548	CHD6	100	91.918	Heterocephalus_glaber_female
ENSG00000124177	CHD6	99	98.980	ENSHGLG00100006401	CHD6	100	91.918	Heterocephalus_glaber_male
ENSG00000124177	CHD6	99	81.783	ENSIPUG00000003692	chd6	74	76.316	Ictalurus_punctatus
ENSG00000124177	CHD6	99	99.660	ENSSTOG00000013382	CHD6	100	92.466	Ictidomys_tridecemlineatus
ENSG00000124177	CHD6	99	86.434	ENSLACG00000010881	CHD6	86	77.121	Latimeria_chalumnae
ENSG00000124177	CHD6	99	84.109	ENSLOCG00000007386	chd6	84	75.785	Lepisosteus_oculatus
ENSG00000124177	CHD6	99	99.660	ENSLAFG00000012144	CHD6	100	92.065	Loxodonta_africana
ENSG00000124177	CHD6	100	100.000	ENSMFAG00000032830	CHD6	100	98.270	Macaca_fascicularis
ENSG00000124177	CHD6	100	100.000	ENSMMUG00000020458	CHD6	100	98.270	Macaca_mulatta
ENSG00000124177	CHD6	100	100.000	ENSMNEG00000040847	CHD6	100	98.270	Macaca_nemestrina
ENSG00000124177	CHD6	99	100.000	ENSMLEG00000031965	CHD6	100	98.226	Mandrillus_leucophaeus
ENSG00000124177	CHD6	99	81.467	ENSMAMG00000013111	chd6	62	77.379	Mastacembelus_armatus
ENSG00000124177	CHD6	99	93.411	ENSMGAG00000001121	CHD6	100	72.080	Meleagris_gallopavo
ENSG00000124177	CHD6	99	98.837	ENSMICG00000016641	CHD6	99	94.270	Microcebus_murinus
ENSG00000124177	CHD6	93	84.892	ENSMOCG00000014004	-	97	94.444	Microtus_ochrogaster
ENSG00000124177	CHD6	99	96.911	ENSMODG00000000720	-	99	81.387	Monodelphis_domestica
ENSG00000124177	CHD6	99	96.599	MGP_CAROLIEiJ_G0024604	Chd6	100	94.684	Mus_caroli
ENSG00000124177	CHD6	99	96.599	ENSMUSG00000057133	Chd6	100	94.599	Mus_musculus
ENSG00000124177	CHD6	99	96.939	MGP_PahariEiJ_G0026048	Chd6	100	95.021	Mus_pahari
ENSG00000124177	CHD6	99	96.599	MGP_SPRETEiJ_G0025526	Chd6	100	94.684	Mus_spretus
ENSG00000124177	CHD6	99	99.660	ENSMPUG00000017695	CHD6	100	90.176	Mustela_putorius_furo
ENSG00000124177	CHD6	99	99.320	ENSMLUG00000016247	CHD6	100	91.363	Myotis_lucifugus
ENSG00000124177	CHD6	99	81.176	ENSNBRG00000013839	chd6	79	72.309	Neolamprologus_brichardi
ENSG00000124177	CHD6	99	99.561	ENSNLEG00000006496	CHD6	99	97.153	Nomascus_leucogenys
ENSG00000124177	CHD6	99	100.000	ENSOPRG00000013376	-	100	87.615	Ochotona_princeps
ENSG00000124177	CHD6	99	81.081	ENSONIG00000000393	chd6	88	73.585	Oreochromis_niloticus
ENSG00000124177	CHD6	99	96.512	ENSOANG00000014347	CHD6	99	70.290	Ornithorhynchus_anatinus
ENSG00000124177	CHD6	99	100.000	ENSOCUG00000012394	CHD6	100	89.849	Oryctolagus_cuniculus
ENSG00000124177	CHD6	98	78.988	ENSORLG00020021891	chd6	95	85.972	Oryzias_latipes_hni
ENSG00000124177	CHD6	99	100.000	ENSOGAG00000002427	CHD6	100	91.753	Otolemur_garnettii
ENSG00000124177	CHD6	99	100.000	ENSOARG00000002597	CHD6	100	86.260	Ovis_aries
ENSG00000124177	CHD6	99	99.660	ENSPPRG00000014756	CHD6	100	91.988	Panthera_pardus
ENSG00000124177	CHD6	99	99.660	ENSPTIG00000011094	CHD6	100	91.878	Panthera_tigris_altaica
ENSG00000124177	CHD6	100	100.000	ENSPTRG00000013504	CHD6	100	99.816	Pan_troglodytes
ENSG00000124177	CHD6	100	100.000	ENSPANG00000025554	CHD6	100	98.233	Papio_anubis
ENSG00000124177	CHD6	99	83.721	ENSPKIG00000005578	chd6	79	72.518	Paramormyrops_kingsleyae
ENSG00000124177	CHD6	99	81.395	ENSPMGG00000014877	chd6	88	76.671	Periophthalmus_magnuspinnatus
ENSG00000124177	CHD6	90	85.821	ENSPEMG00000014672	-	95	94.615	Peromyscus_maniculatus_bairdii
ENSG00000124177	CHD6	99	96.525	ENSPCIG00000028037	CHD6	100	81.122	Phascolarctos_cinereus
ENSG00000124177	CHD6	99	80.309	ENSPLAG00000003128	chd6	68	72.826	Poecilia_latipinna
ENSG00000124177	CHD6	99	80.309	ENSPREG00000022653	chd6	99	86.447	Poecilia_reticulata
ENSG00000124177	CHD6	100	99.329	ENSPPYG00000011016	CHD6	100	99.227	Pongo_abelii
ENSG00000124177	CHD6	99	100.000	ENSPCOG00000001089	CHD6	99	93.771	Propithecus_coquereli
ENSG00000124177	CHD6	99	80.695	ENSPNYG00000022516	chd6	78	74.079	Pundamilia_nyererei
ENSG00000124177	CHD6	99	84.109	ENSPNAG00000012825	chd6	79	70.663	Pygocentrus_nattereri
ENSG00000124177	CHD6	99	96.599	ENSRNOG00000016744	Chd6	100	87.541	Rattus_norvegicus
ENSG00000124177	CHD6	99	100.000	ENSSBOG00000022089	CHD6	100	96.944	Saimiri_boliviensis_boliviensis
ENSG00000124177	CHD6	99	96.525	ENSSHAG00000017072	CHD6	100	80.528	Sarcophilus_harrisii
ENSG00000124177	CHD6	97	84.884	ENSSFOG00015012920	chd6	81	73.026	Scleropages_formosus
ENSG00000124177	CHD6	69	100.000	ENSSARG00000002615	-	61	99.342	Sorex_araneus
ENSG00000124177	CHD6	99	99.660	ENSSSCG00000007360	CHD6	100	91.591	Sus_scrofa
ENSG00000124177	CHD6	98	79.151	ENSTNIG00000017487	chd6	100	57.371	Tetraodon_nigroviridis
ENSG00000124177	CHD6	99	95.918	ENSTTRG00000013438	CHD6	100	88.216	Tursiops_truncatus
ENSG00000124177	CHD6	91	99.660	ENSUAMG00000024036	CHD6	95	96.332	Ursus_americanus
ENSG00000124177	CHD6	99	99.660	ENSUMAG00000002017	CHD6	95	96.332	Ursus_maritimus
ENSG00000124177	CHD6	97	88.710	ENSVPAG00000007941	CHD6	95	89.802	Vicugna_pacos
ENSG00000124177	CHD6	99	99.660	ENSVVUG00000029164	CHD6	100	91.731	Vulpes_vulpes
ENSG00000124177	CHD6	98	85.328	ENSXETG00000021445	chd6	89	69.871	Xenopus_tropicalis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001221	transcription cofactor binding	16314513.	IPI	Function
GO:0003677	DNA binding	-	IEA	Function
GO:0004386	helicase activity	-	IEA	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005654	nucleoplasm	17027977.	IDA	Component
GO:0006325	chromatin organization	-	IEA	Process
GO:0008094	DNA-dependent ATPase activity	17027977.	IDA	Function
GO:0016032	viral process	-	IEA	Process
GO:0036091	positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress	16314513.	IMP	Process