EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000124196 (Gene tree)
Gene ID: 149699
Gene Symbol: GTSF1L
Alias: dJ1028D15.4|C20orf65|FAM112A
Full Name: gametocyte specific factor 1 like
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 852 bases
Position: chr20:43,726,161-43,727,012
Accession: 16198
RBP type: canonical RBP
Summary: GTSF1L (Gametocyte Specific Factor 1 Like) is a Protein Coding gene. An important paralog of this gene is GTSF1.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000362096	zf-U11-48K	PF05253.12	3.6e-18	1	2
ENSP00000362096	zf-U11-48K	PF05253.12	3.6e-18	2	2
ENSP00000362094	zf-U11-48K	PF05253.12	5.8e-18	1	2
ENSP00000362094	zf-U11-48K	PF05253.12	5.8e-18	2	2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000373003	GTSF1L-201	835	-	ENSP00000362094	148 (aa)	-	Q9H1H1
ENST00000373005	GTSF1L-202	459	XM_005260298	ENSP00000362096	123 (aa)	XP_005260355	Q9H1H1

Gene Model

Click here to download ENSG00000124196's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000124196	Alcoholism	6.2E-05	-
ENSG00000124196	Blood Pressure	6.3409840E-005	-
ENSG00000124196	Platelet Function Tests	8.6600000E-006	-
ENSG00000124196	Platelet Function Tests	1.0612600E-005	-
ENSG00000124196	Platelet Function Tests	3.9100000E-006	-
ENSG00000124196	Platelet Function Tests	4.9400000E-006	-
ENSG00000124196	Drug Resistance	4E-6	22952603

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000124196's network

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000124196	GTSF1L	100	72.727	ENSAMEG00000019599	GTSF1L	100	72.727	Ailuropoda_melanoleuca
ENSG00000124196	GTSF1L	100	75.676	ENSANAG00000037122	GTSF1L	100	75.676	Aotus_nancymaae
ENSG00000124196	GTSF1L	91	73.529	ENSBTAG00000011233	GTSF1L	80	73.529	Bos_taurus
ENSG00000124196	GTSF1L	99	73.684	ENSCAFG00000009338	GTSF1L	90	73.684	Canis_familiaris
ENSG00000124196	GTSF1L	93	76.642	ENSCAFG00020013648	GTSF1L	87	76.642	Canis_lupus_dingo
ENSG00000124196	GTSF1L	91	75.735	ENSCHIG00000020800	GTSF1L	98	75.556	Capra_hircus
ENSG00000124196	GTSF1L	93	62.857	ENSTSYG00000033591	GTSF1L	98	62.857	Carlito_syrichta
ENSG00000124196	GTSF1L	94	67.626	ENSCAPG00000000639	GTSF1L	98	67.626	Cavia_aperea
ENSG00000124196	GTSF1L	94	67.626	ENSCPOG00000008201	GTSF1L	98	67.626	Cavia_porcellus
ENSG00000124196	GTSF1L	100	86.992	ENSCCAG00000023964	GTSF1L	100	86.992	Cebus_capucinus
ENSG00000124196	GTSF1L	100	91.870	ENSCATG00000030101	GTSF1L	100	91.870	Cercocebus_atys
ENSG00000124196	GTSF1L	100	92.568	ENSCSAG00000018751	GTSF1L	100	92.568	Chlorocebus_sabaeus
ENSG00000124196	GTSF1L	100	75.163	ENSCHOG00000001631	GTSF1L	100	75.163	Choloepus_hoffmanni
ENSG00000124196	GTSF1L	100	91.057	ENSCANG00000041242	GTSF1L	100	91.057	Colobus_angolensis_palliatus
ENSG00000124196	GTSF1L	93	72.993	ENSCGRG00001016445	Gtsf1l	90	72.993	Cricetulus_griseus_chok1gshd
ENSG00000124196	GTSF1L	93	72.993	ENSCGRG00000018672	Gtsf1l	90	72.993	Cricetulus_griseus_crigri
ENSG00000124196	GTSF1L	100	76.471	ENSDNOG00000003520	GTSF1L	100	76.471	Dasypus_novemcinctus
ENSG00000124196	GTSF1L	99	67.081	ENSECAG00000011252	GTSF1L	91	67.081	Equus_caballus
ENSG00000124196	GTSF1L	100	70.779	ENSEEUG00000005522	GTSF1L	99	70.779	Erinaceus_europaeus
ENSG00000124196	GTSF1L	74	81.319	ENSFCAG00000011143	GTSF1L	92	76.768	Felis_catus
ENSG00000124196	GTSF1L	91	80.597	ENSLAFG00000008405	GTSF1L	100	80.597	Loxodonta_africana
ENSG00000124196	GTSF1L	100	92.683	ENSMFAG00000000223	GTSF1L	100	92.683	Macaca_fascicularis
ENSG00000124196	GTSF1L	100	92.683	ENSMMUG00000031325	GTSF1L	100	92.683	Macaca_mulatta
ENSG00000124196	GTSF1L	100	93.496	ENSMNEG00000040264	GTSF1L	100	93.496	Macaca_nemestrina
ENSG00000124196	GTSF1L	100	91.057	ENSMLEG00000028489	GTSF1L	100	91.057	Mandrillus_leucophaeus
ENSG00000124196	GTSF1L	100	83.065	ENSMICG00000031457	GTSF1L	100	83.065	Microcebus_murinus
ENSG00000124196	GTSF1L	93	72.263	ENSMOCG00000008147	Gtsf1l	89	72.263	Microtus_ochrogaster
ENSG00000124196	GTSF1L	91	74.627	MGP_CAROLIEiJ_G0024611	Gtsf1l	87	74.627	Mus_caroli
ENSG00000124196	GTSF1L	91	75.373	ENSMUSG00000070708	Gtsf1l	87	75.373	Mus_musculus
ENSG00000124196	GTSF1L	92	75.000	MGP_PahariEiJ_G0026055	Gtsf1l	89	75.000	Mus_pahari
ENSG00000124196	GTSF1L	91	76.119	MGP_SPRETEiJ_G0025533	Gtsf1l	87	76.119	Mus_spretus
ENSG00000124196	GTSF1L	100	73.377	ENSMPUG00000019027	GTSF1L	100	73.377	Mustela_putorius_furo
ENSG00000124196	GTSF1L	100	92.683	ENSNLEG00000029652	-	100	92.683	Nomascus_leucogenys
ENSG00000124196	GTSF1L	100	68.456	ENSOPRG00000002095	GTSF1L	100	68.456	Ochotona_princeps
ENSG00000124196	GTSF1L	100	77.852	ENSOGAG00000007706	GTSF1L	100	77.852	Otolemur_garnettii
ENSG00000124196	GTSF1L	100	71.795	ENSOARG00000005486	GTSF1L	100	71.795	Ovis_aries
ENSG00000124196	GTSF1L	79	75.510	ENSPPRG00000023086	GTSF1L	98	75.510	Panthera_pardus
ENSG00000124196	GTSF1L	72	84.091	ENSPTIG00000017302	GTSF1L	88	84.091	Panthera_tigris_altaica
ENSG00000124196	GTSF1L	100	93.496	ENSPANG00000003347	GTSF1L	100	93.496	Papio_anubis
ENSG00000124196	GTSF1L	100	96.748	ENSPPYG00000011024	GTSF1L	100	96.748	Pongo_abelii
ENSG00000124196	GTSF1L	100	78.862	ENSPCOG00000013630	GTSF1L	100	78.862	Propithecus_coquereli
ENSG00000124196	GTSF1L	100	91.870	ENSRBIG00000032329	GTSF1L	100	91.870	Rhinopithecus_bieti
ENSG00000124196	GTSF1L	100	91.057	ENSRROG00000036399	GTSF1L	100	91.057	Rhinopithecus_roxellana
ENSG00000124196	GTSF1L	100	90.244	ENSSBOG00000033121	GTSF1L	100	90.244	Saimiri_boliviensis_boliviensis
ENSG00000124196	GTSF1L	100	73.377	ENSUAMG00000026367	GTSF1L	100	73.377	Ursus_americanus
ENSG00000124196	GTSF1L	100	73.377	ENSUMAG00000000902	GTSF1L	100	73.377	Ursus_maritimus
ENSG00000124196	GTSF1L	100	70.946	ENSVVUG00000019198	GTSF1L	98	70.946	Vulpes_vulpes

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0046872	metal ion binding	-	IEA	Function

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr20	43726286	Missense_Mutation	NA	E137Q	0.65
BLCA	chr20	43726629	Silent	NA	F22F	0.28
BRCA	chr20	43726271	Nonsense_Mutation	novel	K142*	0.17
BRCA	chr20	43726272	Silent	rs760198409	Q141Q	0.16
BRCA	chr20	43726434	Silent	NA	Q87Q	0.2
COAD	chr20	43726823	5'UTR	rs759267912		0.35
COAD	chr20	43726332	Frame_Shift_Del	NA	*P122Lfs50**	0.33
COAD	chr20	43726877	5'UTR	novel		0.07
COAD	chr20	43726429	Missense_Mutation	novel	D89G	0.3
COAD	chr20	43726332	Frame_Shift_Del	NA	*P122Lfs50**	0.31
ESCA	chr20	43726736	5'UTR	rs758285202		0.07
ESCA	chr20	43726439	Nonsense_Mutation	novel	E86*	0.3
ESCA	chr20	43726302	Silent	rs375809336	T131T	0.72
GBM	chr20	43726347	Silent	novel	V116V	0.45
HNSC	chr20	43726785	5'UTR	novel		0.32
LGG	chr20	43726332	Frame_Shift_Del	NA	*P122Lfs50**	0.14
LGG	chr20	43726611	Silent	rs187317274	S28S	0.33
LIHC	chr20	43726599	Missense_Mutation	NA	K32N	0.26
LUAD	chr20	43726774	5'UTR	novel		0.56
LUAD	chr20	43726758	5'UTR	novel		0.3
LUAD	chr20	43726518	Missense_Mutation	novel	H59Q	0.3	zf-U11-48K
LUAD	chr20	43726200	3'UTR	novel		0.45
LUSC	chr20	43726277	Missense_Mutation	novel	P140S	0.12
LUSC	chr20	43726404	Nonsense_Mutation	NA	C97*	0.27
LUSC	chr20	43726520	Missense_Mutation	novel	H59Y	0.26	zf-U11-48K
LUSC	chr20	43726666	Missense_Mutation	novel	P10H	0.35
LUSC	chr20	43726818	5'UTR	novel		0.25
LUSC	chr20	43726755	5'UTR	novel		0.38
OV	chr20	43726481	Missense_Mutation	NA	E72K	0.48
PRAD	chr20	43726714	5'UTR	rs200437907		0.18
PRAD	chr20	43726323	Missense_Mutation	rs558143560	K124N	0.42
READ	chr20	43726178	3'UTR	novel		0.39
READ	chr20	43726386	Silent	novel	I103I	0.44
SARC	chr20	43726485	Missense_Mutation	novel	E70D	0.09
SKCM	chr20	43726648	Missense_Mutation	rs138384319	R16Q	0.07
SKCM	chr20	43726605	Silent	NA	R30R	0.14
SKCM	chr20	43726421	Nonsense_Mutation	novel	Q92*	0.21
SKCM	chr20	43726302	Silent	rs375809336	T131T	0.49
SKCM	chr20	43726230	3'UTR	rs780153957		0.15
SKCM	chr20	43726407	Silent	rs759641183	P96P	0.24
SKCM	chr20	43726465	Missense_Mutation	NA	P77L	0.43
SKCM	chr20	43726266	Silent	novel	I143I	0.35
SKCM	chr20	43726628	Nonsense_Mutation	novel	Q23*	0.29
SKCM	chr20	43726728	5'UTR	novel		0.26
SKCM	chr20	43726384	Nonsense_Mutation	novel	W104*	0.67
SKCM	chr20	43726737	5'UTR	rs780016743		0.55
SKCM	chr20	43726599	Silent	NA	K32K	0.15
SKCM	chr20	43726391	Missense_Mutation	rs762812139	D102N	0.32
STAD	chr20	43726332	Frame_Shift_Del	NA	*P122Lfs50**	0.23
STAD	chr20	43726332	Frame_Shift_Del	NA	*P122Lfs50**	0.15
STAD	chr20	43726501	Frame_Shift_Del	novel	*N65Tfs14**	0.21
STAD	chr20	43726212	3'UTR	novel		0.13
STAD	chr20	43726752	5'UTR	novel		0.14
STAD	chr20	43726649	Nonsense_Mutation	rs373893730	R16*	0.15
STAD	chr20	43726332	Frame_Shift_Del	NA	*P122Lfs50**	0.34
THYM	chr20	43726494	Missense_Mutation	novel	S67R	0.64
UCEC	chr20	43726676	Nonsense_Mutation	NA	E7*	0.24
UCEC	chr20	43726598	Missense_Mutation	novel	N33H	0.23
UCEC	chr20	43726964	5'UTR	novel		0.37
UCEC	chr20	43726332	Frame_Shift_Del	NA	*P122Lfs50**	0.11
UCEC	chr20	43726362	Silent	NA	C111C	0.12
UCEC	chr20	43726530	Silent	NA	N55N	0.18
UCEC	chr20	43726655	Missense_Mutation	novel	H14Y	0.17
UCEC	chr20	43726557	Silent	rs147615369	N46N	0.34
UCEC	chr20	43726747	5'UTR	novel		0.51
UCEC	chr20	43726879	5'UTR	novel		0.32
UCEC	chr20	43726649	Nonsense_Mutation	rs373893730	R16*	0.41
UCEC	chr20	43726757	5'UTR	novel		0.4
UCEC	chr20	43726703	5'UTR	novel		0.24
UCEC	chr20	43726494	Silent	rs551274767	S67S	0.31
UCEC	chr20	43726703	5'UTR	novel		0.22
UCEC	chr20	43726551	Silent	novel	C48C	0.44

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
LAML	DEL	0.0209	0.14746
LUAD	DEL	0.1221	0.18308
PRAD	AMP	0.0488	0.07085

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0089	Kaplan-Meier Survival Analysis
HNSC	0.00016	Kaplan-Meier Survival Analysis
SKCM	0.00011	Kaplan-Meier Survival Analysis
BRCA	0.00014	Kaplan-Meier Survival Analysis
ESCA	0.048	Kaplan-Meier Survival Analysis
PAAD	0.0025	Kaplan-Meier Survival Analysis
BLCA	0.0011	Kaplan-Meier Survival Analysis
CESC	0.0001	Kaplan-Meier Survival Analysis
UCEC	0.031	Kaplan-Meier Survival Analysis
OV	0.005	Kaplan-Meier Survival Analysis