EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000124207 (Gene tree)
Gene ID: 1434
Gene Symbol: CSE1L
Alias: CAS|XPO2|CSE1
Full Name: chromosome segregation 1 like
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 50,715 bases
Position: chr20:49,046,246-49,096,960
Accession: 2431
RBP type: canonical RBP
Summary: Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000262982	IBN_N	PF03810.19	9.4e-10	1	1
ENSP00000379495	IBN_N	PF03810.19	1.1e-09	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000396192	CSE1L-202	3459	-	ENSP00000379495	915 (aa)	-	P55060
ENST00000262982	CSE1L-201	3553	XM_011528599	ENSP00000262982	971 (aa)	-	P55060
ENST00000469700	CSE1L-203	1401	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000124207's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000124207	Iron	6.5050000E-004	19880490
ENSG00000124207	Depressive Disorder	7E-7	27622933
ENSG00000124207	Citalopram	7E-7	27622933
ENSG00000124207	Mood Disorders	7E-7	27622933
ENSG00000124207	Emotions	2E-8	27089181
ENSG00000124207	Emotions	1E-6	27089181

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000124207	rs6063349	20	49065345	?	Non-response to citalopram or escitalopram and depression	27622933	[1.11-1.27]	1.183432	EFO_0003761\|EFO_0007871\|EFO_0006329\|EFO_0004247
ENSG00000124207	rs2075677	20	49084487	A	Subjective well-being	27089181	[0.011-0.024] unit increase	0.0175	EFO_0007869
ENSG00000124207	rs1538482	20	49088959	T	Positive affect	27089181	[0.011-0.025] unit increase	0.0177	EFO_0007869
ENSG00000124207	rs2075679	20	49085052	T	Subjective well-being (MTAG)	29292387	[0.008-0.0154] unit decrease	0.0117	EFO_0007869
ENSG00000124207	rs2064853	20	49058639	A	Intelligence (MTAG)	29326435	[0.021-0.032] unit increase	0.026579602	EFO_0004337
ENSG00000124207	rs113315451	20	49061487	A	Intelligence	28530673	z score increase	5.707	EFO_0004337
ENSG00000124207	rs113315451	20	49061487	A	Intelligence	28530673	z score increase	5.707	EFO_0004337
ENSG00000124207	rs6095417	20	49061664	A	General cognitive ability	29844566	z-score increase	7.724	EFO_0004337
ENSG00000124207	rs2064853	20	49058639	A	General cognitive ability	29844566	z-score increase	7.616	EFO_0004337
ENSG00000124207	rs6019624	20	49069278	?	Reaction time	29844566	[0.0051-0.012] unit increase	0.0085344	EFO_0008393
ENSG00000124207	rs1538482	20	49088959	?	Body fat percentage	30593698	[0.1-0.19] unit decrease	0.14468	EFO_0007800
ENSG00000124207	rs1538482	20	49088959	?	Body fat percentage	30593698	[0.071-0.181] unit decrease	0.12586	EFO_0007800
ENSG00000124207	rs6090940	20	49049490	T	Life satisfaction	30643256	[0.011-0.023] unit increase	0.017017476	EFO_0007869
ENSG00000124207	rs2075677	20	49084487	G	Positive affect	30643256	[0.014-0.024] unit increase	0.018964553	EFO_0007869

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000124207's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000124207	CSE1L	100	89.083	ENSAPOG00000015943	cse1l	100	89.083	Acanthochromis_polyacanthus
ENSG00000124207	CSE1L	100	99.588	ENSAMEG00000013717	CSE1L	100	99.588	Ailuropoda_melanoleuca
ENSG00000124207	CSE1L	100	86.557	ENSACIG00000020004	cse1l	100	86.557	Amphilophus_citrinellus
ENSG00000124207	CSE1L	100	88.980	ENSAOCG00000004356	cse1l	100	88.980	Amphiprion_ocellaris
ENSG00000124207	CSE1L	100	89.083	ENSAPEG00000016588	cse1l	100	89.083	Amphiprion_percula
ENSG00000124207	CSE1L	100	89.186	ENSATEG00000005414	cse1l	100	89.186	Anabas_testudineus
ENSG00000124207	CSE1L	100	95.469	ENSAPLG00000010368	CSE1L	100	95.469	Anas_platyrhynchos
ENSG00000124207	CSE1L	100	94.233	ENSACAG00000015951	CSE1L	100	94.233	Anolis_carolinensis
ENSG00000124207	CSE1L	100	97.631	ENSANAG00000023526	CSE1L	100	97.631	Aotus_nancymaae
ENSG00000124207	CSE1L	100	85.067	ENSACLG00000023214	cse1l	99	85.273	Astatotilapia_calliptera
ENSG00000124207	CSE1L	100	87.539	ENSAMXG00000016416	cse1l	100	87.539	Astyanax_mexicanus
ENSG00000124207	CSE1L	100	99.794	ENSBTAG00000005957	CSE1L	100	99.794	Bos_taurus
ENSG00000124207	CSE1L	99	30.761	WBGene00002079	xpo-2	100	30.761	Caenorhabditis_elegans
ENSG00000124207	CSE1L	100	99.794	ENSCJAG00000016296	CSE1L	100	99.794	Callithrix_jacchus
ENSG00000124207	CSE1L	100	99.794	ENSCAFG00000011260	CSE1L	99	99.794	Canis_familiaris
ENSG00000124207	CSE1L	100	99.454	ENSCAFG00020016114	CSE1L	100	99.454	Canis_lupus_dingo
ENSG00000124207	CSE1L	100	99.485	ENSCHIG00000016579	CSE1L	100	99.485	Capra_hircus
ENSG00000124207	CSE1L	100	99.897	ENSTSYG00000013400	CSE1L	100	99.897	Carlito_syrichta
ENSG00000124207	CSE1L	100	80.109	ENSCAPG00000000237	-	100	80.109	Cavia_aperea
ENSG00000124207	CSE1L	100	88.568	ENSCAPG00000004349	-	100	88.568	Cavia_aperea
ENSG00000124207	CSE1L	100	88.363	ENSCPOG00000023180	-	100	88.363	Cavia_porcellus
ENSG00000124207	CSE1L	100	99.382	ENSCPOG00000005554	-	100	99.382	Cavia_porcellus
ENSG00000124207	CSE1L	100	99.897	ENSCCAG00000014373	CSE1L	100	99.897	Cebus_capucinus
ENSG00000124207	CSE1L	100	100.000	ENSCATG00000039153	CSE1L	100	100.000	Cercocebus_atys
ENSG00000124207	CSE1L	100	97.425	ENSCLAG00000006169	CSE1L	100	97.425	Chinchilla_lanigera
ENSG00000124207	CSE1L	100	100.000	ENSCSAG00000014977	CSE1L	100	100.000	Chlorocebus_sabaeus
ENSG00000124207	CSE1L	100	95.675	ENSCHOG00000004640	CSE1L	100	95.675	Choloepus_hoffmanni
ENSG00000124207	CSE1L	100	95.675	ENSCPBG00000026743	CSE1L	100	95.675	Chrysemys_picta_bellii
ENSG00000124207	CSE1L	98	63.430	ENSCING00000002277	-	99	62.913	Ciona_intestinalis
ENSG00000124207	CSE1L	98	62.591	ENSCSAVG00000003299	-	98	62.591	Ciona_savignyi
ENSG00000124207	CSE1L	100	97.734	ENSCANG00000041300	CSE1L	100	97.734	Colobus_angolensis_palliatus
ENSG00000124207	CSE1L	100	99.485	ENSCGRG00001005670	Cse1l	100	99.485	Cricetulus_griseus_chok1gshd
ENSG00000124207	CSE1L	100	99.485	ENSCGRG00000012164	Cse1l	100	99.485	Cricetulus_griseus_crigri
ENSG00000124207	CSE1L	100	87.436	ENSCSEG00000002471	cse1l	100	87.436	Cynoglossus_semilaevis
ENSG00000124207	CSE1L	100	88.465	ENSCVAG00000004319	cse1l	100	88.465	Cyprinodon_variegatus
ENSG00000124207	CSE1L	100	86.612	ENSDARG00000006963	cse1l	100	86.612	Danio_rerio
ENSG00000124207	CSE1L	100	99.794	ENSDNOG00000014906	CSE1L	100	99.794	Dasypus_novemcinctus
ENSG00000124207	CSE1L	91	100.000	ENSDORG00000013960	Cse1l	100	100.000	Dipodomys_ordii
ENSG00000124207	CSE1L	99	51.679	FBgn0022213	Cse1	99	51.679	Drosophila_melanogaster
ENSG00000124207	CSE1L	73	79.596	ENSEBUG00000011135	cse1l	92	79.596	Eptatretus_burgeri
ENSG00000124207	CSE1L	100	99.485	ENSEASG00005023345	CSE1L	100	99.454	Equus_asinus_asinus
ENSG00000124207	CSE1L	100	99.279	ENSECAG00000015543	CSE1L	97	99.279	Equus_caballus
ENSG00000124207	CSE1L	100	88.260	ENSELUG00000001309	cse1l	100	88.260	Esox_lucius
ENSG00000124207	CSE1L	100	100.000	ENSFCAG00000001446	CSE1L	100	100.000	Felis_catus
ENSG00000124207	CSE1L	100	95.469	ENSFALG00000012932	CSE1L	97	95.469	Ficedula_albicollis
ENSG00000124207	CSE1L	100	98.907	ENSFDAG00000005180	CSE1L	100	98.907	Fukomys_damarensis
ENSG00000124207	CSE1L	86	88.621	ENSFHEG00000005939	cse1l	93	88.621	Fundulus_heteroclitus
ENSG00000124207	CSE1L	100	86.097	ENSGMOG00000007944	cse1l	100	86.097	Gadus_morhua
ENSG00000124207	CSE1L	100	95.469	ENSGALG00000004707	CSE1L	100	95.469	Gallus_gallus
ENSG00000124207	CSE1L	100	88.774	ENSGAFG00000021631	cse1l	100	88.774	Gambusia_affinis
ENSG00000124207	CSE1L	100	87.745	ENSGACG00000000963	cse1l	100	87.745	Gasterosteus_aculeatus
ENSG00000124207	CSE1L	97	95.440	ENSGAGG00000012815	CSE1L	99	95.440	Gopherus_agassizii
ENSG00000124207	CSE1L	100	99.897	ENSGGOG00000010875	CSE1L	100	99.897	Gorilla_gorilla
ENSG00000124207	CSE1L	100	88.671	ENSHBUG00000013599	cse1l	100	88.671	Haplochromis_burtoni
ENSG00000124207	CSE1L	100	99.279	ENSHGLG00000009067	CSE1L	100	99.279	Heterocephalus_glaber_female
ENSG00000124207	CSE1L	100	90.216	ENSHGLG00000014944	-	100	90.216	Heterocephalus_glaber_female
ENSG00000124207	CSE1L	100	99.279	ENSHGLG00100001243	CSE1L	100	99.279	Heterocephalus_glaber_male
ENSG00000124207	CSE1L	100	90.216	ENSHGLG00100014942	-	100	90.216	Heterocephalus_glaber_male
ENSG00000124207	CSE1L	100	87.869	ENSHCOG00000005034	cse1l	100	87.869	Hippocampus_comes
ENSG00000124207	CSE1L	100	87.539	ENSIPUG00000023752	cse1l	100	87.539	Ictalurus_punctatus
ENSG00000124207	CSE1L	100	99.382	ENSSTOG00000003600	CSE1L	100	99.382	Ictidomys_tridecemlineatus
ENSG00000124207	CSE1L	100	99.176	ENSJJAG00000016509	Cse1l	100	99.176	Jaculus_jaculus
ENSG00000124207	CSE1L	100	88.980	ENSKMAG00000021099	cse1l	100	88.980	Kryptolebias_marmoratus
ENSG00000124207	CSE1L	100	87.539	ENSLBEG00000012480	cse1l	100	86.995	Labrus_bergylta
ENSG00000124207	CSE1L	100	91.246	ENSLACG00000015970	CSE1L	100	91.246	Latimeria_chalumnae
ENSG00000124207	CSE1L	100	89.495	ENSLOCG00000003099	cse1l	100	89.495	Lepisosteus_oculatus
ENSG00000124207	CSE1L	100	99.177	ENSLAFG00000006607	CSE1L	100	99.177	Loxodonta_africana
ENSG00000124207	CSE1L	100	100.000	ENSMFAG00000034230	CSE1L	100	100.000	Macaca_fascicularis
ENSG00000124207	CSE1L	100	100.000	ENSMMUG00000019636	CSE1L	100	100.000	Macaca_mulatta
ENSG00000124207	CSE1L	100	100.000	ENSMNEG00000031340	CSE1L	100	100.000	Macaca_nemestrina
ENSG00000124207	CSE1L	95	96.592	ENSMLEG00000042388	CSE1L	100	96.592	Mandrillus_leucophaeus
ENSG00000124207	CSE1L	100	87.848	ENSMAMG00000023931	cse1l	100	87.848	Mastacembelus_armatus
ENSG00000124207	CSE1L	100	88.465	ENSMZEG00005010674	cse1l	100	88.465	Maylandia_zebra
ENSG00000124207	CSE1L	100	99.588	ENSMAUG00000001362	Cse1l	100	99.588	Mesocricetus_auratus
ENSG00000124207	CSE1L	100	99.588	ENSMICG00000001988	CSE1L	100	99.588	Microcebus_murinus
ENSG00000124207	CSE1L	100	99.382	ENSMOCG00000013597	Cse1l	100	99.382	Microtus_ochrogaster
ENSG00000124207	CSE1L	100	84.243	ENSMMOG00000021787	cse1l	100	84.243	Mola_mola
ENSG00000124207	CSE1L	100	97.322	ENSMODG00000016269	CSE1L	100	97.322	Monodelphis_domestica
ENSG00000124207	CSE1L	100	87.745	ENSMALG00000017385	cse1l	100	87.745	Monopterus_albus
ENSG00000124207	CSE1L	100	99.126	MGP_CAROLIEiJ_G0024698	Cse1l	100	99.126	Mus_caroli
ENSG00000124207	CSE1L	100	99.126	ENSMUSG00000002718	Cse1l	100	99.126	Mus_musculus
ENSG00000124207	CSE1L	100	98.798	MGP_PahariEiJ_G0026140	Cse1l	100	98.798	Mus_pahari
ENSG00000124207	CSE1L	100	99.126	MGP_SPRETEiJ_G0025618	Cse1l	100	99.126	Mus_spretus
ENSG00000124207	CSE1L	100	99.485	ENSMPUG00000017586	CSE1L	99	99.485	Mustela_putorius_furo
ENSG00000124207	CSE1L	100	97.322	ENSMLUG00000008368	CSE1L	100	97.322	Myotis_lucifugus
ENSG00000124207	CSE1L	100	99.074	ENSNGAG00000001115	Cse1l	100	99.074	Nannospalax_galili
ENSG00000124207	CSE1L	100	88.568	ENSNBRG00000005053	cse1l	100	88.568	Neolamprologus_brichardi
ENSG00000124207	CSE1L	100	98.661	ENSNLEG00000006945	CSE1L	100	98.661	Nomascus_leucogenys
ENSG00000124207	CSE1L	75	87.556	ENSMEUG00000005658	-	73	87.556	Notamacropus_eugenii
ENSG00000124207	CSE1L	95	98.699	ENSOPRG00000014530	CSE1L	90	98.699	Ochotona_princeps
ENSG00000124207	CSE1L	100	99.344	ENSODEG00000006918	-	100	99.344	Octodon_degus
ENSG00000124207	CSE1L	100	88.877	ENSONIG00000018970	cse1l	100	88.877	Oreochromis_niloticus
ENSG00000124207	CSE1L	100	95.778	ENSOANG00000006402	CSE1L	99	95.778	Ornithorhynchus_anatinus
ENSG00000124207	CSE1L	100	99.280	ENSOCUG00000005459	CSE1L	100	99.280	Oryctolagus_cuniculus
ENSG00000124207	CSE1L	100	88.054	ENSORLG00000000603	cse1l	100	88.054	Oryzias_latipes
ENSG00000124207	CSE1L	100	85.137	ENSORLG00020007653	cse1l	100	85.137	Oryzias_latipes_hni
ENSG00000124207	CSE1L	56	88.807	ENSORLG00015003694	cse1l	97	88.807	Oryzias_latipes_hsok
ENSG00000124207	CSE1L	100	88.568	ENSOMEG00000014357	cse1l	100	88.568	Oryzias_melastigma
ENSG00000124207	CSE1L	100	97.639	ENSOGAG00000002126	CSE1L	100	97.639	Otolemur_garnettii
ENSG00000124207	CSE1L	100	99.486	ENSOARG00000012031	CSE1L	100	99.486	Ovis_aries
ENSG00000124207	CSE1L	100	100.000	ENSPPAG00000038391	CSE1L	100	100.000	Pan_paniscus
ENSG00000124207	CSE1L	100	100.000	ENSPPRG00000022681	CSE1L	100	100.000	Panthera_pardus
ENSG00000124207	CSE1L	100	100.000	ENSPTIG00000011919	CSE1L	100	100.000	Panthera_tigris_altaica
ENSG00000124207	CSE1L	100	100.000	ENSPTRG00000013599	CSE1L	100	100.000	Pan_troglodytes
ENSG00000124207	CSE1L	100	96.292	ENSPANG00000026147	CSE1L	100	96.292	Papio_anubis
ENSG00000124207	CSE1L	100	88.465	ENSPKIG00000024520	cse1l	100	88.465	Paramormyrops_kingsleyae
ENSG00000124207	CSE1L	100	96.189	ENSPSIG00000010864	CSE1L	99	96.189	Pelodiscus_sinensis
ENSG00000124207	CSE1L	100	99.691	ENSPEMG00000000944	Cse1l	100	99.691	Peromyscus_maniculatus_bairdii
ENSG00000124207	CSE1L	100	97.322	ENSPCIG00000023472	CSE1L	100	97.322	Phascolarctos_cinereus
ENSG00000124207	CSE1L	100	89.392	ENSPFOG00000001989	cse1l	100	89.392	Poecilia_formosa
ENSG00000124207	CSE1L	100	89.289	ENSPLAG00000015012	cse1l	100	89.289	Poecilia_latipinna
ENSG00000124207	CSE1L	100	89.392	ENSPMEG00000022671	cse1l	100	89.392	Poecilia_mexicana
ENSG00000124207	CSE1L	100	89.186	ENSPREG00000009081	cse1l	100	89.186	Poecilia_reticulata
ENSG00000124207	CSE1L	100	100.000	ENSPPYG00000011110	CSE1L	100	100.000	Pongo_abelii
ENSG00000124207	CSE1L	75	99.083	ENSPCAG00000007508	CSE1L	80	99.083	Procavia_capensis
ENSG00000124207	CSE1L	92	99.241	ENSPCOG00000026411	CSE1L	100	99.241	Propithecus_coquereli
ENSG00000124207	CSE1L	99	95.407	ENSPVAG00000015014	CSE1L	100	95.407	Pteropus_vampyrus
ENSG00000124207	CSE1L	100	88.774	ENSPNYG00000007058	cse1l	100	88.774	Pundamilia_nyererei
ENSG00000124207	CSE1L	100	87.230	ENSPNAG00000012903	cse1l	100	87.230	Pygocentrus_nattereri
ENSG00000124207	CSE1L	100	98.352	ENSRNOG00000007665	Cse1l	100	98.352	Rattus_norvegicus
ENSG00000124207	CSE1L	100	100.000	ENSRBIG00000029361	CSE1L	100	100.000	Rhinopithecus_bieti
ENSG00000124207	CSE1L	100	100.000	ENSRROG00000021686	CSE1L	100	100.000	Rhinopithecus_roxellana
ENSG00000124207	CSE1L	96	36.825	YGL238W	CSE1	91	37.823	Saccharomyces_cerevisiae
ENSG00000124207	CSE1L	100	99.897	ENSSBOG00000021396	CSE1L	100	99.897	Saimiri_boliviensis_boliviensis
ENSG00000124207	CSE1L	100	87.642	ENSSFOG00015021428	cse1l	100	87.642	Scleropages_formosus
ENSG00000124207	CSE1L	100	88.157	ENSSMAG00000000580	cse1l	96	88.157	Scophthalmus_maximus
ENSG00000124207	CSE1L	100	88.980	ENSSDUG00000012110	cse1l	100	88.980	Seriola_dumerili
ENSG00000124207	CSE1L	100	88.980	ENSSLDG00000022083	cse1l	100	88.980	Seriola_lalandi_dorsalis
ENSG00000124207	CSE1L	100	95.778	ENSSPUG00000017941	CSE1L	100	95.778	Sphenodon_punctatus
ENSG00000124207	CSE1L	100	88.980	ENSSPAG00000008182	cse1l	100	88.980	Stegastes_partitus
ENSG00000124207	CSE1L	100	99.897	ENSSSCG00000025534	CSE1L	99	99.897	Sus_scrofa
ENSG00000124207	CSE1L	100	95.366	ENSTGUG00000008823	CSE1L	100	95.366	Taeniopygia_guttata
ENSG00000124207	CSE1L	96	85.974	ENSTRUG00000005496	cse1l	97	85.974	Takifugu_rubripes
ENSG00000124207	CSE1L	100	87.642	ENSTNIG00000014631	cse1l	100	87.642	Tetraodon_nigroviridis
ENSG00000124207	CSE1L	100	90.422	ENSTBEG00000008338	CSE1L	100	90.422	Tupaia_belangeri
ENSG00000124207	CSE1L	91	98.684	ENSTTRG00000004279	CSE1L	91	98.684	Tursiops_truncatus
ENSG00000124207	CSE1L	100	99.485	ENSUAMG00000025448	CSE1L	99	99.485	Ursus_americanus
ENSG00000124207	CSE1L	100	99.485	ENSUMAG00000024476	CSE1L	99	99.485	Ursus_maritimus
ENSG00000124207	CSE1L	100	95.263	ENSVPAG00000001312	CSE1L	100	95.263	Vicugna_pacos
ENSG00000124207	CSE1L	100	99.794	ENSVVUG00000022322	CSE1L	99	99.794	Vulpes_vulpes
ENSG00000124207	CSE1L	100	88.363	ENSXETG00000001784	cse1l	100	88.363	Xenopus_tropicalis
ENSG00000124207	CSE1L	100	88.197	ENSXCOG00000000805	cse1l	100	88.197	Xiphophorus_couchianus
ENSG00000124207	CSE1L	100	89.083	ENSXMAG00000001306	cse1l	100	89.083	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005049	nuclear export signal receptor activity	21873635.	IBA	Function
GO:0005515	protein binding	17719542.21209336.	IPI	Function
GO:0005634	nucleus	9323134.	TAS	Component
GO:0005635	nuclear envelope	21873635.	IBA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005737	cytoplasm	9323134.	TAS	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0006606	protein import into nucleus	21873635.	IBA	Process
GO:0006611	protein export from nucleus	21873635.	IBA	Process
GO:0006915	apoptotic process	7479798.	TAS	Process
GO:0008283	cell proliferation	7479798.	TAS	Process
GO:0008536	Ran GTPase binding	-	IEA	Function
GO:0008565	protein transporter activity	21873635.	IBA	Function
GO:0016020	membrane	19946888.	HDA	Component
GO:0070062	extracellular exosome	19056867.20458337.	HDA	Component

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
23806821	CSE1L modulates Ras-induced cancer cell invasion: correlation of K-Ras mutation and CSE1L expression in colorectal cancer progression.	Am J Surg	2013 Sep	Jiang MC	doi: 10.1016/j.amjsurg.2012.11.021
22476051	The prognostic significance of nuclear CSE1L in urinary bladder urothelial carcinomas.	Ann Diagn Pathol	2012 Oct	Chang CC	doi: 10.1016/j.anndiagpath.2012.02.005
23189846	[Expression of CAS in hepatocellular carcinoma tissues and its relationship with HBV infection].	Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi	2012 Aug	Zang H	-
24799195	Prosurvival function of the cellular apoptosis susceptibility/importin-α1 transport cycle is repressed by p53 in liver cancer.	Hepatology	2014 Sep	Winkler J	doi: 10.1002/hep.27207
22952058	CSE1L, a novel microvesicle membrane protein, mediates Ras-triggered microvesicle generation and metastasis of tumor cells.	Mol Med	2012 Dec 6	Liao CF	doi: 10.2119/molmed.2012.00205.
28387323	CSE1L interaction with MSH6 promotes osteosarcoma progression and predicts poor patient survival.	Sci Rep	2017 Apr 7	Cheng DD	doi: 10.1038/srep46238.
22653741	Presence of CSE1L protein in urine of patients with urinary bladder urothelial carcinomas.	Int J Biol Markers	2012 Oct 8	Tai CJ	doi: 10.5301/JBM.2012.9310.
20150437	Serum cellular apoptosis susceptibility protein is a potential prognostic marker for metastatic colorectal cancer.	Am J Pathol	2010 Apr	Stella Tsai CS	doi: 10.2353/ajpath.2010.090467
22450763	Cellular apoptosis susceptibility (chromosome segregation 1-like, CSE1L) gene is a key regulator of apoptosis, migration and invasion in colorectal cancer.	J Pathol	2012 Dec	Alnabulsi A	doi: 10.1002/path.4031
26278417	Does CSE1L Overexpression Affect Distant Metastasis Development in Breast Cancer?	Oncol Res Treat	2015	Yuksel UM	doi: 10.1159/000438501
28790116	Targeted Proteomics Identifies Proteomic Signatures in Liquid Biopsies of the Endometrium to Diagnose Endometrial Cancer and Assist in the Prediction of the Optimal Surgical Treatment.	Clin Cancer Res	2017 Nov 1	Martinez-Garcia E	doi: 10.1158/1078-0432.CCR-17-0474

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr20	49066451	Missense_Mutation	novel	Q139H	0.12
BLCA	chr20	49089702	Missense_Mutation	NA	E713K	0.06
BLCA	chr20	49074833	Missense_Mutation	NA	R372T	0.3
BLCA	chr20	49063206	Missense_Mutation	novel	E30D	0.08	IBN_N
BLCA	chr20	49066498	Nonsense_Mutation	novel	S155*	0.5
BLCA	chr20	49089541	Missense_Mutation	NA	F659C	0.48
BLCA	chr20	49074833	Missense_Mutation	novel	R372K	0.08
BLCA	chr20	49088070	Missense_Mutation	NA	I595M	0.07
BLCA	chr20	49094753	Missense_Mutation	novel	L872F	0.11
BLCA	chr20	49089563	Silent	NA	V666V	0.17
BLCA	chr20	49088055	Silent	NA	Y590Y	0.27
BLCA	chr20	49090967	Silent	novel	I770I	0.42
BLCA	chr20	49096485	3'UTR	novel		0.23
BLCA	chr20	49066224	Silent	rs756518336	A87A	0.19
BLCA	chr20	49084130	Silent	rs771282629	L529L	0.2
BLCA	chr20	49058476	Missense_Mutation	rs372551577	D5N	0.16
BRCA	chr20	49075317	Splice_Site	novel	X378_splice	0.04
BRCA	chr20	49066498	Missense_Mutation	novel	S155L	0.06
BRCA	chr20	49085374	Missense_Mutation	NA	Y571D	0.2
BRCA	chr20	49070223	Missense_Mutation	NA	E232K	0.11
BRCA	chr20	49096761	3'UTR	novel		0.33
BRCA	chr20	49096485	3'UTR	novel		0.08
BRCA	chr20	49088102	Missense_Mutation	novel	S606I	0.08
CESC	chr20	49075397	Silent	NA	I404I	0.39
CESC	chr20	49074817	Missense_Mutation	NA	E367Q	0.16
CESC	chr20	49072624	Silent	NA	K331K	0.22
CESC	chr20	49085371	Missense_Mutation	NA	E570K	0.23
CESC	chr20	49075505	Silent	novel	K440K	0.42
CESC	chr20	49085302	Missense_Mutation	rs748051425	A547T	0.25
CESC	chr20	49090741	Splice_Site	novel	X728_splice	0.37
CESC	chr20	49074840	Missense_Mutation	NA	L374F	0.14
CHOL	chr20	49066510	Missense_Mutation	novel	R159K	0.42
COAD	chr20	49075371	Frame_Shift_Del	novel	*F397Lfs5**	0.27
COAD	chr20	49072600	Silent	NA	S323S	0.38
COAD	chr20	49074819	Missense_Mutation	NA	E367D	0.14
COAD	chr20	49074820	Nonsense_Mutation	NA	E368*	0.14
COAD	chr20	49085293	Missense_Mutation	novel	A544T	0.36
COAD	chr20	49090828	Silent	rs759049407	E756E	0.18
COAD	chr20	49067227	Missense_Mutation	NA	E172K	0.15
COAD	chr20	49066228	Nonsense_Mutation	NA	R89*	0.29	IBN_N
COAD	chr20	49072343	Missense_Mutation	rs149344844	A276T	0.35
COAD	chr20	49066486	Missense_Mutation	rs753618454	R151H	0.36
COAD	chr20	49084154	Silent	NA	N537N	0.11
COAD	chr20	49089335	Missense_Mutation	NA	V637A	0.33
COAD	chr20	49089541	Missense_Mutation	NA	F659C	0.16
ESCA	chr20	49094177	Missense_Mutation	novel	E829Q	0.39
ESCA	chr20	49088067	Silent	novel	L594L	0.16
ESCA	chr20	49094159	Frame_Shift_Ins	novel	*I825Nfs5**	0.26
GBM	chr20	49094756	Missense_Mutation	novel	I873M	0.08
GBM	chr20	49072428	Missense_Mutation	NA	T304M	0.32
GBM	chr20	49096386	Missense_Mutation	novel	A955V	0.17
GBM	chr20	49085355	Frame_Shift_Del	novel	*G565Afs9**	0.08
GBM	chr20	49090824	Missense_Mutation	novel	I755K	0.08
GBM	chr20	49089248	Missense_Mutation	novel	N608I	0.57
GBM	chr20	49085328	Silent	novel	T555T	0.05
GBM	chr20	49094731	Splice_Site	novel	X865_splice	0.27
HNSC	chr20	49090965	Missense_Mutation	novel	I770V	0.49
HNSC	chr20	49072384	Frame_Shift_Ins	novel	*L290Nfs23**	0.08
HNSC	chr20	49088027	Missense_Mutation	novel	S581Y	0.27
HNSC	chr20	49075377	Missense_Mutation	novel	E398Q	0.08
HNSC	chr20	49066448	Silent	novel	F138F	0.11
KIRC	chr20	49066405	Missense_Mutation	NA	P124Q	0.22
KIRP	chr20	49058488	Missense_Mutation	NA	Q9K	0.1
KIRP	chr20	49074807	Silent	NA	E363E	0.22
KIRP	chr20	49070252	Missense_Mutation	novel	N241K	0.28
KIRP	chr20	49089357	Frame_Shift_Ins	novel	*L646Ffs22**	0.24
LIHC	chr20	49058517	Silent	rs750060417	T18T	0.56
LIHC	chr20	49078616	Silent	novel	R492R	0.3
LIHC	chr20	49066200	Missense_Mutation	novel	D79E	0.34	IBN_N
LUAD	chr20	49066195	Missense_Mutation	NA	E78K	0.36	IBN_N
LUAD	chr20	49094749	Missense_Mutation	novel	S871C	0.07
LUAD	chr20	49058479	Missense_Mutation	NA	A6S	0.86
LUAD	chr20	49058458	5'UTR	novel		0.27
LUAD	chr20	49094834	Nonsense_Mutation	novel	Y899*	0.15
LUAD	chr20	49089539	Missense_Mutation	novel	E658D	0.33
LUAD	chr20	49072364	Missense_Mutation	NA	D283Y	0.14
LUAD	chr20	49075333	Missense_Mutation	NA	R383P	0.22
LUAD	chr20	49094277	Missense_Mutation	rs775701351	T862N	0.21
LUAD	chr20	49072303	Silent	novel	G262G	0.16
LUSC	chr20	49075509	Missense_Mutation	novel	Q442K	0.2
LUSC	chr20	49094846	Silent	NA	F903F	0.4
LUSC	chr20	49075501	Nonsense_Mutation	novel	S439*	0.33
LUSC	chr20	49075317	Splice_Site	novel	X378_splice	0.24
LUSC	chr20	49094196	Missense_Mutation	NA	G835E	0.3
LUSC	chr20	49085296	Missense_Mutation	NA	E545Q	0.14
LUSC	chr20	49094830	Missense_Mutation	novel	G898V	0.11
LUSC	chr20	49072415	Silent	novel	L300L	0.1
OV	chr20	49096621	3'UTR	novel		0.23
OV	chr20	49068802	Missense_Mutation	novel	F219L	0.08
OV	chr20	49070273	Missense_Mutation	NA	L248F	0.17
OV	chr20	49089268	Missense_Mutation	novel	N615H	0.06
OV	chr20	49089594	Missense_Mutation	novel	D677H	0.27
OV	chr20	49094212	Silent	novel	K840K	0.04
OV	chr20	49089334	Missense_Mutation	NA	V637F	0.09
PAAD	chr20	49088059	Missense_Mutation	novel	P592S	0.06
PAAD	chr20	49075415	Missense_Mutation	novel	N410K	0.21
PRAD	chr20	49089706	Missense_Mutation	rs376962564	R714H	0.27
PRAD	chr20	49089707	Silent	rs369869448	R714R	0.16
READ	chr20	49085302	Missense_Mutation	rs748051425	A547T	0.18
READ	chr20	49096565	3'UTR	novel		0.21
SARC	chr20	49090840	Splice_Site	novel	X760_splice	0.19
SKCM	chr20	49072405	Silent	novel	A296A	0.25
SKCM	chr20	49088032	Silent	novel	L583L	0.3
SKCM	chr20	49084023	Splice_Region	novel		0.21
SKCM	chr20	49084147	Missense_Mutation	NA	P535L	0.13
SKCM	chr20	49085378	Missense_Mutation	novel	I572N	0.4
SKCM	chr20	49094258	Missense_Mutation	novel	M856V	0.26
SKCM	chr20	49090793	Missense_Mutation	NA	H745Y	0.36
SKCM	chr20	49070211	Missense_Mutation	rs773304297	P228S	0.16
SKCM	chr20	49096529	3'UTR	novel		0.44
SKCM	chr20	49070211	Missense_Mutation	rs773304297	P228S	0.22
SKCM	chr20	49089378	Silent	NA	I651I	0.28
SKCM	chr20	49066484	Silent	novel	L150L	0.59
SKCM	chr20	49072391	Missense_Mutation	rs372508022	R292C	0.1
SKCM	chr20	49078578	Missense_Mutation	NA	L480F	0.4
SKCM	chr20	49089576	Silent	NA	L671L	0.13
SKCM	chr20	49078604	Silent	NA	I488I	0.25
SKCM	chr20	49090838	Missense_Mutation	novel	P760S	0.51
STAD	chr20	49072600	Silent	NA	S323S	0.11
STAD	chr20	49075370	Frame_Shift_Ins	novel	E398*	0.13
STAD	chr20	49096388	Missense_Mutation	rs769741319	L956I	0.2
STAD	chr20	49063253	Missense_Mutation	novel	L46P	0.46	IBN_N
STAD	chr20	49096363	Silent	NA	V947V	0.31
STAD	chr20	49072380	Missense_Mutation	rs773313816	R288Q	0.08
STAD	chr20	49085307	Silent	rs112036311	P548P	0.14
STAD	chr20	49066225	Missense_Mutation	NA	D88N	0.06	IBN_N
STAD	chr20	49084107	Missense_Mutation	rs746788725	A522T	0.26
STAD	chr20	49072343	Missense_Mutation	rs149344844	A276T	0.49
STAD	chr20	49066254	Silent	novel	V97V	0.28
STAD	chr20	49063255	Missense_Mutation	NA	L47M	0.15	IBN_N
STAD	chr20	49072392	Missense_Mutation	rs746870335	R292H	0.34
UCEC	chr20	49085302	Missense_Mutation	rs748051425	A547T	0.32
UCEC	chr20	49066228	Nonsense_Mutation	NA	R89*	0.3	IBN_N
UCEC	chr20	49084041	Missense_Mutation	rs551478981	L500I	0.3
UCEC	chr20	49090967	Silent	rs751691746	I770I	0.22
UCEC	chr20	49067261	Missense_Mutation	novel	P183H	0.32
UCEC	chr20	49096179	Intron	novel		0.56
UCEC	chr20	49075359	Nonsense_Mutation	novel	G392*	0.3
UCEC	chr20	49085295	Silent	novel	A544A	0.45
UCEC	chr20	49094863	Missense_Mutation	novel	A909V	0.36
UCEC	chr20	49072413	Missense_Mutation	NA	N299T	0.46
UCEC	chr20	49084051	Missense_Mutation	rs761357425	S503L	0.44
UCEC	chr20	49096545	3'UTR	rs573722942		0.64
UCEC	chr20	49096834	3'UTR	rs571119564		0.5
UCEC	chr20	49058528	Missense_Mutation	novel	D22G	0.27
UCEC	chr20	49070204	Splice_Site	novel	X226_splice	0.18
UCEC	chr20	49096847	3'UTR	novel		0.13
UCEC	chr20	49070230	Missense_Mutation	novel	N234T	0.16
UCEC	chr20	49094206	Missense_Mutation	novel	E838D	0.05
UCEC	chr20	49066191	Splice_Site	novel	X77_splice	0.09
UCEC	chr20	49075380	Nonsense_Mutation	NA	G399*	0.22
UCEC	chr20	49085302	Missense_Mutation	rs748051425	A547T	0.25
UCEC	chr20	49063331	Missense_Mutation	NA	R72M	0.38	IBN_N
UCEC	chr20	49072580	Missense_Mutation	NA	A317T	0.31
UCEC	chr20	49075492	Missense_Mutation	novel	S436F	0.32
UCEC	chr20	49072409	Missense_Mutation	novel	W298R	0.26
UCEC	chr20	49075471	Missense_Mutation	rs778061824	A429V	0.16
UCEC	chr20	49096895	3'UTR	novel		0.45
UCEC	chr20	49084140	Nonsense_Mutation	novel	R533*	0.38
UCEC	chr20	49072428	Missense_Mutation	NA	T304M	0.18
UCEC	chr20	49090778	Missense_Mutation	NA	S740P	0.09
UCEC	chr20	49094220	Missense_Mutation	rs749686049	A843V	0.53
UCEC	chr20	49066235	Missense_Mutation	novel	A91V	0.21	IBN_N
UCEC	chr20	49072664	Frame_Shift_Ins	novel	*V347Gfs5**	0.52
UCEC	chr20	49074812	Missense_Mutation	NA	N365S	0.03
UCEC	chr20	49077024	Missense_Mutation	novel	F460L	0.39
UCEC	chr20	49096437	Nonstop_Mutation	novel	972Sext5	0.39
UCEC	chr20	49096401	Frame_Shift_Del	novel	*Y962Tfs7**	0.24
UCEC	chr20	49058511	Missense_Mutation	novel	K16N	0.39
UCEC	chr20	49077024	Missense_Mutation	novel	F460L	0.2
UCEC	chr20	49096461	3'UTR	novel		0.09
UCEC	chr20	49096463	3'UTR	novel		0.09
UCEC	chr20	49070216	Missense_Mutation	novel	E229D	0.44
UCEC	chr20	49084101	Missense_Mutation	novel	T520A	0.25
UCEC	chr20	49084041	Missense_Mutation	rs551478981	L500I	0.38
UCEC	chr20	49058452	Splice_Site	novel		0.22
UCEC	chr20	49084051	Missense_Mutation	rs761357425	S503L	0.26
UCEC	chr20	49066460	Missense_Mutation	novel	D142E	0.16
UCEC	chr20	49072603	Silent	novel	V324V	0.25
UCEC	chr20	49063345	Splice_Site	NA	X76_splice	0.26
UCEC	chr20	49070237	Silent	novel	E236E	0.15
UCEC	chr20	49089389	Nonsense_Mutation	novel	*D655Efs2**	0.04
UCEC	chr20	49084106	Silent	rs140701703	Y521Y	0.29
UCEC	chr20	49066211	Missense_Mutation	NA	K83T	0.5	IBN_N
UCEC	chr20	49094948	Silent	rs753453001	T937T	0.13
UCEC	chr20	49063321	Missense_Mutation	NA	Y69D	0.16	IBN_N
UCEC	chr20	49092125	Frame_Shift_Ins	novel	K816*	0.12
UCEC	chr20	49092127	Frame_Shift_Ins	novel	*M817Pfs25**	0.12
UCEC	chr20	49058531	Missense_Mutation	novel	P23H	0.18
UCEC	chr20	49063278	Missense_Mutation	novel	Q54H	0.19	IBN_N
UCEC	chr20	49066482	Missense_Mutation	novel	L150I	0.16
UCEC	chr20	49089708	Missense_Mutation	rs544269070	G715S	0.19
UCEC	chr20	49092045	Splice_Site	novel	X789_splice	0.32
UCEC	chr20	49090938	Missense_Mutation	NA	E761K	0.34
UCEC	chr20	49072299	Missense_Mutation	novel	A261V	0.5
UCEC	chr20	49058476	Missense_Mutation	rs372551577	D5N	0.12
UCEC	chr20	49063268	Missense_Mutation	novel	E51G	0.47	IBN_N
UCEC	chr20	49075357	Missense_Mutation	novel	R391Q	0.41
UCEC	chr20	49090936	In_Frame_Ins	novel	P760_E761insRSFT	0.06
UCEC	chr20	49092125	Frame_Shift_Ins	novel	K816*	0.04
UCEC	chr20	49092127	Frame_Shift_Ins	novel	*M817Pfs16**	0.03

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
LAML	DEL	0.0209	0.14746
LUAD	DEL	0.1085	0.18308
PRAD	AMP	0.0508	0.07085

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.043	Kaplan-Meier Survival Analysis
SARC	0.00071	Kaplan-Meier Survival Analysis
MESO	0.00012	Kaplan-Meier Survival Analysis
ACC	0.00014	Kaplan-Meier Survival Analysis
KIRP	0.00067	Kaplan-Meier Survival Analysis
PAAD	0.017	Kaplan-Meier Survival Analysis
PCPG	0.023	Kaplan-Meier Survival Analysis
BLCA	0.00085	Kaplan-Meier Survival Analysis
CESC	0.047	Kaplan-Meier Survival Analysis
KICH	0.0074	Kaplan-Meier Survival Analysis
UCEC	0.0001	Kaplan-Meier Survival Analysis
LIHC	0.00011	Kaplan-Meier Survival Analysis
LGG	0.00033	Kaplan-Meier Survival Analysis
LUAD	0.0014	Kaplan-Meier Survival Analysis
UVM	0.0076	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742