EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000124214 (Gene tree)
Gene ID: 6780
Gene Symbol: STAU1
Alias: PPP1R150|STAU
Full Name: staufen double-stranded RNA binding protein 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 75,032 bases
Position: chr20:49,113,339-49,188,370
Accession: 11370
RBP type: canonical RBP
Summary: Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. The STAU gene product has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of translation. Five transcript variants resulting from alternative splicing of STAU gene and encoding three isoforms have been described. Three of these variants encode the same isoform, however, differ in their 5'UTR. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000360857	dsrm	PF00035.26	9.6e-34	1	3
ENSP00000360857	dsrm	PF00035.26	9.6e-34	2	3
ENSP00000360857	dsrm	PF00035.26	9.6e-34	3	3
ENSP00000484011	dsrm	PF00035.26	9.7e-34	1	3
ENSP00000484011	dsrm	PF00035.26	9.7e-34	2	3
ENSP00000484011	dsrm	PF00035.26	9.7e-34	3	3
ENSP00000323443	dsrm	PF00035.26	9.9e-34	1	3
ENSP00000323443	dsrm	PF00035.26	9.9e-34	2	3
ENSP00000323443	dsrm	PF00035.26	9.9e-34	3	3
ENSP00000345425	dsrm	PF00035.26	9.9e-34	1	3
ENSP00000345425	dsrm	PF00035.26	9.9e-34	2	3
ENSP00000345425	dsrm	PF00035.26	9.9e-34	3	3
ENSP00000353604	dsrm	PF00035.26	9.9e-34	1	3
ENSP00000353604	dsrm	PF00035.26	9.9e-34	2	3
ENSP00000353604	dsrm	PF00035.26	9.9e-34	3	3
ENSP00000360922	dsrm	PF00035.26	3.8e-33	1	3
ENSP00000360922	dsrm	PF00035.26	3.8e-33	2	3
ENSP00000360922	dsrm	PF00035.26	3.8e-33	3	3
ENSP00000360867	dsrm	PF00035.26	2e-30	1	3
ENSP00000360867	dsrm	PF00035.26	2e-30	2	3
ENSP00000360867	dsrm	PF00035.26	2e-30	3	3
ENSP00000360893	dsrm	PF00035.26	2e-30	1	3
ENSP00000360893	dsrm	PF00035.26	2e-30	2	3
ENSP00000360893	dsrm	PF00035.26	2e-30	3	3
ENSP00000416779	dsrm	PF00035.26	1e-16	1	2
ENSP00000416779	dsrm	PF00035.26	1e-16	2	2
ENSP00000398785	dsrm	PF00035.26	1.2e-05	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
12773480	The dsRNA binding protein family: critical roles, diverse cellular functions.	FASEB J	2003 Jun	Saunders LR	-
27886048	Interactions between the HIV-1 Unspliced mRNA and Host mRNA Decay Machineries.	Viruses	2016 Nov 23	Toro-Ascuy D	-
24954387	'Black sheep' that don't leave the double-stranded RNA-binding domain fold.	Trends Biochem Sci	2014 Jul	Gleghorn ML	doi: 10.1016/j.tibs.2014.05.003
16905128	Miranda couples oskar mRNA/Staufen complexes to the bicoid mRNA localization pathway.	Dev Biol	2006 Sep 15	Irion U	-
15970630	The mammalian RNA-binding protein Staufen2 links nuclear and cytoplasmic RNA processing pathways in neurons.	Neuromolecular Med	2004	Monshausen M	-
9735369	miranda localizes staufen and prospero asymmetrically in mitotic neuroblasts and epithelial cells in early Drosophila embryogenesis.	Development	1998 Oct	Matsuzaki F	-
20075165	Multimerization of Staufen1 in live cells.	RNA	2010 Mar	Martel C	doi: 10.1261/rna.1664210
18922781	A loss of function allele for murine Staufen1 leads to impairment of dendritic Staufen1-RNP delivery and dendritic spine morphogenesis.	Proc Natl Acad Sci U S A	2008 Oct 21	Vessey JP	doi: 10.1073/pnas.0804583105
18498651	The host protein Staufen1 interacts with the Pr55Gag zinc fingers and regulates HIV-1 assembly via its N-terminus.	Retrovirology	2008 May 22	Chatel-Chaix L	doi: 10.1186/1742-4690-5-41.
26824753	RNA Whole-Mount In situ Hybridisation Proximity Ligation Assay (rISH-PLA), an Assay for Detecting RNA-Protein Complexes in Intact Cells.	PLoS One	2016 Jan 29	Roussis IM	doi: 10.1371/journal.pone.0147967
15707962	Measurement of dendritic mRNA transport using ribosomal markers.	Biochem Biophys Res Commun	2005 Mar 25	Kim HK	-
15303970	Characterization of Staufen 1 ribonucleoprotein complexes.	Biochem J	2004 Dec 1	Brendel C	-
17000903	RNA aptamers binding the double-stranded RNA-binding domain.	RNA	2006 Nov	Hallegger M	-
22481296	Synthetic antibodies as tools to probe RNA-binding protein function.	Mol Biosyst	2012 Jun	Laver JD	doi: 10.1039/c2mb00007e
22202069	Staufen: from embryo polarity to cellular stress and neurodegeneration.	Front Biosci (Schol Ed)	2012 Jan 1	Tosar LJ	-
30655309	UPFront and center in RNA decay: UPF1 in nonsense-mediated mRNA decay and beyond.	RNA	2019 Apr	Kim YK	doi: 10.1261/rna.070136.118
10473638	Microtubule-dependent recruitment of Staufen-green fluorescent protein into large RNA-containing granules and subsequent dendritic transport in living hippocampal neurons.	Mol Biol Cell	1999 Sep	Kohrmann M	-
12133005	Molecular mapping of the determinants involved in human Staufen-ribosome association.	Biochem J	2002 Aug 1	Luo M	-
16377086	Role of Staufen in dendritic mRNA transport and its modulation.	Neurosci Lett	2006 Apr 10-17	Kim KC	-
16377940	The role of mammalian Staufen on mRNA traffic: a view from its nucleocytoplasmic shuttling function.	Cell Struct Funct	2005	Miki T	-
10823848	The double-stranded RNA-binding protein Staufen is incorporated in human immunodeficiency virus type 1: evidence for a role in genomic RNA encapsidation.	J Virol	2000 Jun	Mouland AJ	-
15163628	Xenopus Staufen is a component of a ribonucleoprotein complex containing Vg1 RNA and kinesin.	Development	2004 Jul	Yoon YJ	-
15166236	The brain-specific double-stranded RNA-binding protein Staufen2: nucleolar accumulation and isoform-specific exportin-5-dependent export.	J Biol Chem	2004 Jul 23	Macchi P	-
15024055	Identification of Staufen in the human immunodeficiency virus type 1 Gag ribonucleoprotein complex and a role in generating infectious viral particles.	Mol Cell Biol	2004 Apr	Chatel-Chaix L	-
19182390	Improving the stability of short hairpin RNA against fetal bovine serum using the third double-stranded RNA-binding domain from Staufen protein.	Biol Pharm Bull	2009 Feb	Kawaguchi Y	-
18424275	The Translin/Trax RNA binding complex: clues to function in the nervous system.	Biochim Biophys Acta	2008 Aug	Li Z	doi: 10.1016/j.bbagrm.2008.03.008
17428849	The host protein Staufen1 participates in human immunodeficiency virus type 1 assembly in live cells by influencing pr55Gag multimerization.	J Virol	2007 Jun	Chatel-Chaix L	-
17268469	bicoid RNA localization requires specific binding of an endosomal sorting complex.	Nature	2007 Feb 1	Irion U	-
23263869	Staufen2 functions in Staufen1-mediated mRNA decay by binding to itself and its paralog and promoting UPF1 helicase but not ATPase activity.	Proc Natl Acad Sci U S A	2013 Jan 8	Park E	doi: 10.1073/pnas.1213508110
23195953	RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans.	J Biol Chem	2013 Jan 25	LeGendre JB	doi: 10.1074/jbc.M112.397349
25012293	The multifunctional Staufen proteins: conserved roles from neurogenesis to synaptic plasticity.	Trends Neurosci	2014 Sep	Heraud-Farlow JE	doi: 10.1016/j.tins.2014.05.009
23945942	Genome-wide analysis of Staufen-associated mRNAs identifies secondary structures that confer target specificity.	Nucleic Acids Res	2013 Nov	Laver JD	doi: 10.1093/nar/gkt702
23681777	Staufen-mediated mRNA decay.	Wiley Interdiscip Rev RNA	2013 Jul-Aug	Park E	doi: 10.1002/wrna.1168
29374155	Kruppel-like factor 4-dependent Staufen1-mediated mRNA decay regulates cortical neurogenesis.	Nat Commun	2018 Jan 26	Moon BS	doi: 10.1038/s41467-017-02720-9.
30744035	Staufen1 Protein Participates Positively in the Viral RNA Replication of Enterovirus 71.	Viruses	2019 Feb 8	Chen YM	doi: 10.3390/v11020142.
15951029	A human immunodeficiency virus type 1 protease biosensor assay using bioluminescence resonance energy transfer.	J Virol Methods	2005 Sep	Hu K	-
15525674	Staufen recruitment into stress granules does not affect early mRNA transport in oligodendrocytes.	Mol Biol Cell	2005 Jan	Thomas MG	-
10022908	A human sequence homologue of Staufen is an RNA-binding protein that is associated with polysomes and localizes to the rough endoplasmic reticulum.	Mol Cell Biol	1999 Mar	Marion RM	-
10022909	Mammalian staufen is a double-stranded-RNA- and tubulin-binding protein which localizes to the rough endoplasmic reticulum.	Mol Cell Biol	1999 Mar	Wickham L	-
9870958	The mammalian staufen protein localizes to the somatodendritic domain of cultured hippocampal neurons: implications for its involvement in mRNA transport.	J Neurosci	1999 Jan 1	Kiebler MA	-
1438302	A conserved double-stranded RNA-binding domain.	Proc Natl Acad Sci U S A	1992 Nov 15	St Johnston D	-
9486649	Staufen-dependent localization of prospero mRNA contributes to neuroblast daughter-cell fate.	Nature	1998 Feb 19	Broadus J	-
10444389	A staufen-like RNA-binding protein in translocation channels linking nurse cells to oocytes in Notonecta shows nucleotide-dependent attachment to microtubules.	J Cell Sci	1999 Sep	Hurst S	-
8884277	Localization of a human double-stranded RNA-binding protein gene (STAU) to band 20q13.1 by fluorescence in situ hybridization.	Genomics	1996 Sep 15	DesGroseillers L	-
7729524	Assignment of the backbone 1H,15N,13C NMR resonances and secondary structure of a double-stranded RNA binding domain from the Drosophila protein staufen.	FEBS Lett	1995 Apr 10	Bycroft M	-
12859680	Localization of the RNA-binding proteins Staufen1 and Staufen2 at the mammalian neuromuscular junction.	J Neurochem	2003 Aug	Belanger G	-
12695554	Expression profiling of osteosarcoma cells transfected with MDR1 and NEO genes: regulation of cell adhesion, apoptosis, and tumor suppression-related genes.	Lab Invest	2003 Apr	Sanchez-Carbayo M	-
16513105	Zebrafish Staufen1 and Staufen2 are required for the survival and migration of primordial germ cells.	Dev Biol	2006 Apr 15	Ramasamy S	-
12065664	The RNA-binding protein Staufen from rat brain interacts with protein phosphatase-1.	J Neurochem	2002 May	Monshausen M	-
11044460	Mouse staufen genes are expressed in germ cells during oogenesis and spermatogenesis.	Mol Hum Reprod	2000 Nov	Saunders PT	-
10882232	Genomic organization of the human and mouse stau genes.	DNA Cell Biol	2000 Jun	Brizard F	-
10716936	Distinct roles of two conserved Staufen domains in oskar mRNA localization and translation.	EMBO J	2000 Mar 15	Micklem DR	-
16221671	Mammalian Smaug is a translational repressor that forms cytoplasmic foci similar to stress granules.	J Biol Chem	2005 Dec 30	Baez MV	-
16186820	CBP80 promotes interaction of Upf1 with Upf2 during nonsense-mediated mRNA decay in mammalian cells.	Nat Struct Mol Biol	2005 Oct	Hosoda N	-
16162096	Staufen1 is imported into the nucleolus via a bipartite nuclear localization signal and several modulatory determinants.	Biochem J	2006 Jan 1	Martel C	-
15811346	Polarised distribution of the RNA-binding protein Staufen in differentiated intestinal epithelial cells.	FEBS Lett	2005 Apr 11	Gautrey H	-
15721032	Model for the robust establishment of precise proportions in the early Drosophila embryo.	J Theor Biol	2005 May 7	Aegerter-Wilmsen T	-
15680326	Mammalian Staufen1 recruits Upf1 to specific mRNA 3'UTRs so as to elicit mRNA decay.	Cell	2005 Jan 28	Kim YK	-
15567725	Expression of the zebrafish Staufen gene in the embryo and adult.	Gene Expr Patterns	2004 Dec	Bateman MJ	-
15496522	Two distinct Staufen isoforms in Xenopus are vegetally localized during oogenesis.	RNA	2004 Nov	Allison R	-
16809002	The RNA binding and transport proteins staufen and fragile X mental retardation protein are expressed by rat primary afferent neurons and localize to peripheral and central axons.	Neuroscience	2006 Sep 15	Price TJ	-
15121898	The composition of Staufen-containing RNA granules from human cells indicates their role in the regulated transport and translation of messenger RNAs.	Nucleic Acids Res	2004 Apr 30	Villace P	-
19193871	Mammalian Staufen 1 is recruited to stress granules and impairs their assembly.	J Cell Sci	2009 Feb 15	Thomas MG	doi: 10.1242/jcs.038208.
18585410	Staufen1 is expressed in preimplantation mouse embryos and is required for embryonic stem cell differentiation.	Biochim Biophys Acta	2008 Oct	Gautrey H	doi: 10.1016/j.bbamcr.2008.05.017
18405437	Bovine oocytes and early embryos express Staufen and ELAVL RNA-binding proteins.	Zygote	2008 May	Calder MD	doi: 10.1017/S096719940700456X.
18316402	Staufen1 regulation of protein synthesis-dependent long-term potentiation and synaptic function in hippocampal pyramidal cells.	Mol Cell Biol	2008 May	Lebeau G	doi: 10.1128/MCB.01844-07
22940085	The double-stranded RNA-binding protein Staufen 2 regulates eye size.	Mol Cell Neurosci	2012 Nov	Cockburn DM	doi: 10.1016/j.mcn.2012.08.008
18088371	TDP-43, the signature protein of FTLD-U, is a neuronal activity-responsive factor.	J Neurochem	2008 May	Wang IF	-
22892953	Myotonic dystrophy: is a narrow focus obscuring the rest of the field?	Curr Opin Neurol	2012 Oct	Mahadevan MS	doi: 10.1097/WCO.0b013e328357b0d9.
17587311	The transport of Staufen2-containing ribonucleoprotein complexes involves kinesin motor protein and is modulated by mitogen-activated protein kinase pathway.	J Neurochem	2007 Sep	Jeong JH	doi: 10.1111/j.1471-4159.2007.04697.x
17510634	Staufen1 regulates diverse classes of mammalian transcripts.	EMBO J	2007 Jun 6	Kim YK	-
17182790	Identification of process-localized mRNAs from cultured rodent hippocampal neurons.	J Neurosci	2006 Dec 20	Poon MM	-
22503102	Staufen1-mediated mRNA decay functions in adipogenesis.	Mol Cell	2012 May 25	Cho H	doi: 10.1016/j.molcel.2012.03.009
22166206	Stau1 regulates Dvl2 expression during myoblast differentiation.	Biochem Biophys Res Commun	2012 Jan 6	Yamaguchi Y	doi: 10.1016/j.bbrc.2011.11.133
21508097	Staufen 2 regulates mGluR long-term depression and Map1b mRNA distribution in hippocampal neurons.	Learn Mem	2011 Apr 20	Lebeau G	doi: 10.1101/lm.2100611
21436445	Mutations in the RNA granule component TDRD7 cause cataract and glaucoma.	Science	2011 Mar 25	Lachke SA	doi: 10.1126/science.1195970.
25423178	Human Staufen1 associates to miRNAs involved in neuronal cell differentiation and is required for correct dendritic formation.	PLoS One	2014 Nov 25	Peredo J	doi: 10.1371/journal.pone.0113704
24906885	Cell cycle-dependent regulation of the RNA-binding protein Staufen1.	Nucleic Acids Res	2014 Jul	Boulay K	doi: 10.1093/nar/gku506
27106056	Staufen1 promotes HCV replication by inhibiting protein kinase R and transporting viral RNA to the site of translation and replication in the cells.	Nucleic Acids Res	2016 Jun 20	Dixit U	doi: 10.1093/nar/gkw312
26921297	Staufen Negatively Modulates MicroRNA Activity in Caenorhabditis elegans.	G3 (Bethesda)	2016 May 3	Ren Z	doi: 10.1534/g3.116.027300.
26824521	Staufen1 Regulates Multiple Alternative Splicing Events either Positively or Negatively in DM1 Indicating Its Role as a Disease Modifier.	PLoS Genet	2016 Jan 29	Bondy-Chorney E	doi: 10.1371/journal.pgen.1005827
26045787	Screening of APP interaction proteins by DUALmembrane yeast two-hybrid system.	Int J Clin Exp Pathol	2015 Mar 1	Yu Y	-
25879614	Analysis of RNA decay factor mediated RNA stability contributions on RNA abundance.	BMC Genomics	2015 Mar 6	Maekawa S	doi: 10.1186/s12864-015-1358-y.
27644878	Hypoxia and ER stress promote Staufen1 expression through an alternative translation mechanism.	Biochem Biophys Res Commun	2016 Oct 14	Bonnet-Magnaval F	doi: 10.1016/j.bbrc.2016.09.082
29099484	Lin28B and miR-142-3p regulate neuronal differentiation by modulating Staufen1 expression.	Cell Death Differ	2018 Feb	Oh Y	doi: 10.1038/cdd.2017.182
29580384	The asymmetrically segregating lncRNA cherub is required for transforming stem cells into malignant cells.	Elife	2018 Mar 27	Landskron L	doi: 10.7554/eLife.31347.
29979632	STAU1 binds to IBDV genomic double-stranded RNA and promotes viral replication via attenuation of MDA5-dependent β interferon induction.	FASEB J	2019 Jan	Ye C	doi: 10.1096/fj.201800062RR
30037924	Ooplasmic flow cooperates with transport and anchorage in Drosophila oocyte posterior determination.	J Cell Biol	2018 Oct 1	Lu W	doi: 10.1083/jcb.201709174
30061410	Double-stranded RNA binding protein, Staufen, is required for the initiation of RNAi in coleopteran insects.	Proc Natl Acad Sci U S A	2018 Aug 14	Yoon JS	doi: 10.1073/pnas.1809381115
26423004	The structural basis of Miranda-mediated Staufen localization during Drosophila neuroblast asymmetric division.	Nat Commun	2015 Oct 1	Jia M	doi: 10.1038/ncomms9381.
23201690	Control of somatic tissue differentiation by the long non-coding RNA TINCR.	Nature	2013 Jan 10	Kretz M	doi: 10.1038/nature11661
24799437	Staufen1-mediated mRNA decay induces Requiem mRNA decay through binding of Staufen1 to the Requiem 3'UTR.	Nucleic Acids Res	2014 Jun	Kim MY	doi: 10.1093/nar/gku388
15312650	Kinesin transports RNA: isolation and characterization of an RNA-transporting granule.	Neuron	2004 Aug 19	Kanai Y	-
18806890	Characterization of a novel transcript variant of human STAU1 gene.	Acta Biochim Pol	2008	Fa-Hui N	-
21307942	lncRNAs transactivate STAU1-mediated mRNA decay by duplexing with 3' UTRs via Alu elements.	Nature	2011 Feb 10	Gong C	doi: 10.1038/nature09701.
24336223	Staufen1 senses overall transcript secondary structure to regulate translation.	Nat Struct Mol Biol	2014 Jan	Ricci EP	doi: 10.1038/nsmb.2739
24056942	mRNA-mRNA duplexes that autoelicit Staufen1-mediated mRNA decay.	Nat Struct Mol Biol	2013 Oct	Gong C	doi: 10.1038/nsmb.2664
23524536	Staufen1 dimerizes through a conserved motif and a degenerate dsRNA-binding domain to promote mRNA decay.	Nat Struct Mol Biol	2013 Apr	Gleghorn ML	doi: 10.1038/nsmb.2528

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000371792	STAU1-204	3130	-	ENSP00000360857	494 (aa)	-	Q5JW30
ENST00000340954	STAU1-201	3334	-	ENSP00000345425	496 (aa)	-	O95793
ENST00000437404	STAU1-208	1085	-	ENSP00000416779	199 (aa)	-	Q5JW28
ENST00000371802	STAU1-205	3154	-	ENSP00000360867	502 (aa)	-	O95793
ENST00000347458	STAU1-202	3136	XM_024451973	ENSP00000323443	496 (aa)	XP_024307741	O95793
ENST00000360426	STAU1-203	3211	-	ENSP00000353604	496 (aa)	-	O95793
ENST00000614381	STAU1-210	3054	XM_011529015	ENSP00000484011	493 (aa)	XP_011527317	A0A087X1A5
ENST00000371828	STAU1-206	3411	XM_005260527	ENSP00000360893	502 (aa)	XP_005260584	O95793
ENST00000456866	STAU1-209	643	-	ENSP00000398785	129 (aa)	-	F6UDC6
ENST00000371856	STAU1-207	3684	XM_006723865	ENSP00000360922	577 (aa)	XP_006723928	O95793

Gene Model

Click here to download ENSG00000124214's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000124214	Body Height	2E-24	25282103

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000124214	rs348276	20	49169653	?	Cognitive ability	29186694	z score increase	5.699	EFO_0004337
ENSG00000124214	rs141979783	20	49172238	?	Cognitive ability (MTAG)	29186694	z score increase	5.708	EFO_0004337\|EFO_0004784
ENSG00000124214	rs2273653	20	49154219	C	Depressive symptoms	29292387	[0.0097-0.0191] unit decrease	0.0144	EFO_0007006
ENSG00000124214	rs2273653	20	49154219	C	Depressive symptoms (MTAG)	29292387	[0.01-0.019] unit decrease	0.0144	EFO_0007006
ENSG00000124214	rs13041213	20	49184292	A	Intelligence (MTAG)	29326435	[0.018-0.032] unit increase	0.024943719	EFO_0004337
ENSG00000124214	rs17450430	20	49155727	A	Height	25282103	[0.029-0.041] unit decrease	0.035	EFO_0004339
ENSG00000124214	rs8118105	20	49182127	?	Reaction time	29844566	[0.0046-0.0115] unit decrease	0.0080467	EFO_0008393
ENSG00000124214	rs6066975	20	49133840	A	Depression	29942085	z score decrease	5.471	EFO_0003761
ENSG00000124214	rs34841991	20	49130437	C	Hedonic well-being	30279531	[0.014-0.03] unit increase	0.022	EFO_0007869
ENSG00000124214	rs8122757	20	49145712	?	Lung function (FVC)	30595370			EFO_0004312
ENSG00000124214	rs2273653	20	49154219	C	Well-being spectrum (multivariate analysis)	30643256	[0.0044-0.008] unit decrease	0.006190459	EFO_0007869

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000124214's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000124214	STAU1	100	57.635	ENSG00000040341	STAU2	100	53.271
ENSG00000124214	STAU1	58	31.383	ENSG00000180228	PRKRA	62	31.053

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000124214	STAU1	99	73.852	ENSAPOG00000017260	stau1	93	71.455	Acanthochromis_polyacanthus
ENSG00000124214	STAU1	99	96.040	ENSAMEG00000013681	STAU1	95	96.040	Ailuropoda_melanoleuca
ENSG00000124214	STAU1	99	75.149	ENSACIG00000015918	stau1	96	75.794	Amphilophus_citrinellus
ENSG00000124214	STAU1	99	75.050	ENSAOCG00000012224	stau1	96	72.575	Amphiprion_ocellaris
ENSG00000124214	STAU1	99	75.050	ENSAPEG00000012308	stau1	96	72.575	Amphiprion_percula
ENSG00000124214	STAU1	99	75.252	ENSATEG00000024600	stau1	99	74.755	Anabas_testudineus
ENSG00000124214	STAU1	99	89.759	ENSAPLG00000010527	STAU1	94	88.650	Anas_platyrhynchos
ENSG00000124214	STAU1	99	89.780	ENSACAG00000015909	STAU1	95	88.672	Anolis_carolinensis
ENSG00000124214	STAU1	100	99.497	ENSANAG00000032714	STAU1	100	98.456	Aotus_nancymaae
ENSG00000124214	STAU1	99	73.852	ENSACLG00000012270	stau1	96	73.204	Astatotilapia_calliptera
ENSG00000124214	STAU1	100	74.349	ENSAMXG00000016812	stau1	99	70.884	Astyanax_mexicanus
ENSG00000124214	STAU1	100	95.494	ENSBTAG00000000241	STAU1	100	95.494	Bos_taurus
ENSG00000124214	STAU1	100	99.497	ENSCJAG00000016233	STAU1	100	99.480	Callithrix_jacchus
ENSG00000124214	STAU1	100	96.707	ENSCAFG00000011347	STAU1	100	95.155	Canis_familiaris
ENSG00000124214	STAU1	100	95.155	ENSCAFG00020017123	STAU1	100	95.155	Canis_lupus_dingo
ENSG00000124214	STAU1	100	95.147	ENSCHIG00000001799	-	100	95.147	Capra_hircus
ENSG00000124214	STAU1	100	96.371	ENSTSYG00000036179	-	100	95.494	Carlito_syrichta
ENSG00000124214	STAU1	100	94.332	ENSCAPG00000017041	STAU1	100	94.332	Cavia_aperea
ENSG00000124214	STAU1	96	96.875	ENSCPOG00000005566	STAU1	100	93.131	Cavia_porcellus
ENSG00000124214	STAU1	100	99.203	ENSCCAG00000034339	STAU1	100	98.285	Cebus_capucinus
ENSG00000124214	STAU1	100	99.497	ENSCATG00000028474	STAU1	100	99.480	Cercocebus_atys
ENSG00000124214	STAU1	99	96.970	ENSCLAG00000006516	-	100	96.970	Chinchilla_lanigera
ENSG00000124214	STAU1	100	78.427	ENSCLAG00000002784	-	100	78.427	Chinchilla_lanigera
ENSG00000124214	STAU1	100	99.194	ENSCSAG00000014986	STAU1	100	99.194	Chlorocebus_sabaeus
ENSG00000124214	STAU1	100	97.405	ENSCHOG00000001511	STAU1	100	97.405	Choloepus_hoffmanni
ENSG00000124214	STAU1	99	89.780	ENSCPBG00000026741	STAU1	96	88.672	Chrysemys_picta_bellii
ENSG00000124214	STAU1	100	99.307	ENSCANG00000039220	STAU1	100	99.307	Colobus_angolensis_palliatus
ENSG00000124214	STAU1	99	91.515	ENSCGRG00001013453	Stau1	100	91.515	Cricetulus_griseus_chok1gshd
ENSG00000124214	STAU1	99	91.515	ENSCGRG00000007216	Stau1	100	91.515	Cricetulus_griseus_crigri
ENSG00000124214	STAU1	99	67.273	ENSCSEG00000000792	stau1	74	65.918	Cynoglossus_semilaevis
ENSG00000124214	STAU1	99	72.414	ENSCVAG00000005906	stau1	99	69.497	Cyprinodon_variegatus
ENSG00000124214	STAU1	99	73.930	ENSDARG00000044182	stau1	96	73.786	Danio_rerio
ENSG00000124214	STAU1	100	97.924	ENSDNOG00000014933	STAU1	98	97.924	Dasypus_novemcinctus
ENSG00000124214	STAU1	99	91.207	ENSDORG00000030220	Stau1	100	91.207	Dipodomys_ordii
ENSG00000124214	STAU1	88	97.537	ENSETEG00000018235	STAU1	88	97.537	Echinops_telfairi
ENSG00000124214	STAU1	100	97.211	ENSEASG00005023343	STAU1	100	96.686	Equus_asinus_asinus
ENSG00000124214	STAU1	100	97.400	ENSECAG00000012894	STAU1	100	97.400	Equus_caballus
ENSG00000124214	STAU1	90	100.000	ENSEEUG00000014344	STAU1	80	100.000	Erinaceus_europaeus
ENSG00000124214	STAU1	99	73.084	ENSELUG00000002529	stau1	93	70.696	Esox_lucius
ENSG00000124214	STAU1	100	96.880	ENSFCAG00000001447	STAU1	100	96.880	Felis_catus
ENSG00000124214	STAU1	99	87.627	ENSFALG00000012940	STAU1	96	87.549	Ficedula_albicollis
ENSG00000124214	STAU1	98	77.551	ENSFDAG00000020837	-	100	73.939	Fukomys_damarensis
ENSG00000124214	STAU1	99	96.162	ENSFDAG00000014119	-	100	96.162	Fukomys_damarensis
ENSG00000124214	STAU1	99	73.453	ENSFHEG00000013517	stau1	96	73.386	Fundulus_heteroclitus
ENSG00000124214	STAU1	100	63.208	ENSGMOG00000016850	stau1	77	61.733	Gadus_morhua
ENSG00000124214	STAU1	99	90.264	ENSGALG00000004736	STAU1	96	90.119	Gallus_gallus
ENSG00000124214	STAU1	99	73.653	ENSGAFG00000010437	stau1	96	73.777	Gambusia_affinis
ENSG00000124214	STAU1	99	73.904	ENSGACG00000001352	stau1	96	71.322	Gasterosteus_aculeatus
ENSG00000124214	STAU1	99	89.452	ENSGAGG00000009825	STAU1	96	89.328	Gopherus_agassizii
ENSG00000124214	STAU1	100	99.801	ENSGGOG00000025351	STAU1	100	100.000	Gorilla_gorilla
ENSG00000124214	STAU1	99	74.052	ENSHBUG00000023668	stau1	96	73.398	Haplochromis_burtoni
ENSG00000124214	STAU1	99	97.137	ENSHGLG00000008730	STAU1	100	97.137	Heterocephalus_glaber_female
ENSG00000124214	STAU1	99	97.137	ENSHGLG00100000098	STAU1	100	97.137	Heterocephalus_glaber_male
ENSG00000124214	STAU1	99	71.227	ENSHCOG00000018461	stau1	92	68.156	Hippocampus_comes
ENSG00000124214	STAU1	94	74.948	ENSIPUG00000023725	stau1	95	74.948	Ictalurus_punctatus
ENSG00000124214	STAU1	99	96.319	ENSSTOG00000003634	STAU1	100	96.319	Ictidomys_tridecemlineatus
ENSG00000124214	STAU1	99	94.070	ENSJJAG00000020032	Stau1	100	94.070	Jaculus_jaculus
ENSG00000124214	STAU1	99	71.774	ENSKMAG00000007135	stau1	93	72.353	Kryptolebias_marmoratus
ENSG00000124214	STAU1	99	72.332	ENSLBEG00000020172	stau1	96	69.871	Labrus_bergylta
ENSG00000124214	STAU1	99	83.333	ENSLACG00000016157	STAU1	96	83.333	Latimeria_chalumnae
ENSG00000124214	STAU1	99	80.080	ENSLOCG00000003134	stau1	96	77.570	Lepisosteus_oculatus
ENSG00000124214	STAU1	100	95.363	ENSLAFG00000003238	STAU1	100	95.481	Loxodonta_africana
ENSG00000124214	STAU1	100	99.497	ENSMFAG00000040931	STAU1	100	99.480	Macaca_fascicularis
ENSG00000124214	STAU1	100	99.497	ENSMMUG00000002302	STAU1	100	99.402	Macaca_mulatta
ENSG00000124214	STAU1	100	99.497	ENSMNEG00000033821	STAU1	100	99.480	Macaca_nemestrina
ENSG00000124214	STAU1	100	99.395	ENSMLEG00000031383	STAU1	100	99.307	Mandrillus_leucophaeus
ENSG00000124214	STAU1	99	75.654	ENSMAMG00000017586	stau1	99	73.120	Mastacembelus_armatus
ENSG00000124214	STAU1	99	73.852	ENSMZEG00005015605	stau1	96	70.686	Maylandia_zebra
ENSG00000124214	STAU1	99	89.960	ENSMGAG00000004719	STAU1	94	88.845	Meleagris_gallopavo
ENSG00000124214	STAU1	99	91.111	ENSMAUG00000013846	Stau1	100	91.111	Mesocricetus_auratus
ENSG00000124214	STAU1	100	96.985	ENSMICG00000001995	STAU1	100	96.055	Microcebus_murinus
ENSG00000124214	STAU1	99	92.727	ENSMOCG00000018743	Stau1	100	92.727	Microtus_ochrogaster
ENSG00000124214	STAU1	100	73.737	ENSMMOG00000015455	stau1	99	73.992	Mola_mola
ENSG00000124214	STAU1	100	93.347	ENSMODG00000016276	STAU1	99	93.124	Monodelphis_domestica
ENSG00000124214	STAU1	99	74.850	ENSMALG00000000045	stau1	96	72.388	Monopterus_albus
ENSG00000124214	STAU1	99	92.197	MGP_CAROLIEiJ_G0024699	Stau1	100	92.197	Mus_caroli
ENSG00000124214	STAU1	99	91.581	ENSMUSG00000039536	Stau1	100	91.581	Mus_musculus
ENSG00000124214	STAU1	99	91.786	MGP_PahariEiJ_G0026141	Stau1	100	91.786	Mus_pahari
ENSG00000124214	STAU1	99	91.170	MGP_SPRETEiJ_G0025619	Stau1	100	91.170	Mus_spretus
ENSG00000124214	STAU1	99	96.634	ENSMPUG00000017581	STAU1	99	96.634	Mustela_putorius_furo
ENSG00000124214	STAU1	100	96.774	ENSMLUG00000008407	STAU1	98	96.707	Myotis_lucifugus
ENSG00000124214	STAU1	99	94.545	ENSNGAG00000007108	Stau1	100	94.545	Nannospalax_galili
ENSG00000124214	STAU1	99	74.052	ENSNBRG00000017596	stau1	96	73.398	Neolamprologus_brichardi
ENSG00000124214	STAU1	100	99.307	ENSNLEG00000006955	STAU1	100	99.307	Nomascus_leucogenys
ENSG00000124214	STAU1	93	93.723	ENSMEUG00000003263	STAU1	99	86.387	Notamacropus_eugenii
ENSG00000124214	STAU1	100	93.159	ENSOPRG00000014569	STAU1	100	88.811	Ochotona_princeps
ENSG00000124214	STAU1	100	96.356	ENSODEG00000006523	STAU1	100	96.356	Octodon_degus
ENSG00000124214	STAU1	99	74.251	ENSONIG00000004152	stau1	95	73.592	Oreochromis_niloticus
ENSG00000124214	STAU1	100	88.442	ENSOANG00000006394	STAU1	96	88.281	Ornithorhynchus_anatinus
ENSG00000124214	STAU1	100	95.363	ENSOCUG00000006214	STAU1	100	94.454	Oryctolagus_cuniculus
ENSG00000124214	STAU1	99	72.545	ENSOMEG00000002388	stau1	96	70.225	Oryzias_melastigma
ENSG00000124214	STAU1	100	97.581	ENSOGAG00000002127	STAU1	98	96.880	Otolemur_garnettii
ENSG00000124214	STAU1	99	66.467	ENSOGAG00000028222	-	99	66.935	Otolemur_garnettii
ENSG00000124214	STAU1	100	95.147	ENSOARG00000012204	STAU1	100	94.695	Ovis_aries
ENSG00000124214	STAU1	100	99.801	ENSPPAG00000032023	STAU1	100	100.000	Pan_paniscus
ENSG00000124214	STAU1	100	96.774	ENSPPRG00000003436	STAU1	100	96.774	Panthera_pardus
ENSG00000124214	STAU1	100	96.774	ENSPTIG00000011768	STAU1	100	96.707	Panthera_tigris_altaica
ENSG00000124214	STAU1	100	99.801	ENSPTRG00000023130	STAU1	100	100.000	Pan_troglodytes
ENSG00000124214	STAU1	100	99.480	ENSPANG00000020560	STAU1	100	99.480	Papio_anubis
ENSG00000124214	STAU1	99	74.451	ENSPKIG00000024588	stau1	93	72.171	Paramormyrops_kingsleyae
ENSG00000124214	STAU1	99	89.249	ENSPSIG00000010731	STAU1	95	89.130	Pelodiscus_sinensis
ENSG00000124214	STAU1	99	75.150	ENSPMGG00000018553	stau1	99	72.470	Periophthalmus_magnuspinnatus
ENSG00000124214	STAU1	99	91.515	ENSPEMG00000022045	Stau1	100	91.515	Peromyscus_maniculatus_bairdii
ENSG00000124214	STAU1	100	93.725	ENSPCIG00000023269	STAU1	100	92.788	Phascolarctos_cinereus
ENSG00000124214	STAU1	99	73.828	ENSPFOG00000017253	stau1	96	73.828	Poecilia_formosa
ENSG00000124214	STAU1	95	64.767	ENSPLAG00000014829	stau1	81	70.552	Poecilia_latipinna
ENSG00000124214	STAU1	94	73.125	ENSPMEG00000007495	stau1	94	73.125	Poecilia_mexicana
ENSG00000124214	STAU1	99	73.242	ENSPREG00000003477	stau1	96	73.242	Poecilia_reticulata
ENSG00000124214	STAU1	100	99.395	ENSPPYG00000011111	STAU1	100	99.307	Pongo_abelii
ENSG00000124214	STAU1	100	93.467	ENSPCAG00000002459	STAU1	100	88.787	Procavia_capensis
ENSG00000124214	STAU1	100	97.487	ENSPCOG00000027746	STAU1	100	97.400	Propithecus_coquereli
ENSG00000124214	STAU1	85	98.261	ENSPVAG00000015019	STAU1	86	96.939	Pteropus_vampyrus
ENSG00000124214	STAU1	99	74.052	ENSPNYG00000014436	stau1	96	73.398	Pundamilia_nyererei
ENSG00000124214	STAU1	99	73.114	ENSPNAG00000011323	stau1	96	73.501	Pygocentrus_nattereri
ENSG00000124214	STAU1	99	91.717	ENSRNOG00000007781	Stau1	100	91.717	Rattus_norvegicus
ENSG00000124214	STAU1	100	99.497	ENSRBIG00000037345	STAU1	100	99.402	Rhinopithecus_bieti
ENSG00000124214	STAU1	100	99.480	ENSRROG00000039008	STAU1	100	99.480	Rhinopithecus_roxellana
ENSG00000124214	STAU1	100	99.203	ENSSBOG00000034448	STAU1	100	98.285	Saimiri_boliviensis_boliviensis
ENSG00000124214	STAU1	100	93.548	ENSSHAG00000009492	STAU1	97	93.717	Sarcophilus_harrisii
ENSG00000124214	STAU1	99	77.062	ENSSFOG00015021497	stau1	99	70.451	Scleropages_formosus
ENSG00000124214	STAU1	99	74.850	ENSSMAG00000017410	stau1	96	72.201	Scophthalmus_maximus
ENSG00000124214	STAU1	99	75.649	ENSSDUG00000019439	stau1	96	72.948	Seriola_dumerili
ENSG00000124214	STAU1	99	75.649	ENSSLDG00000025040	stau1	93	72.948	Seriola_lalandi_dorsalis
ENSG00000124214	STAU1	64	94.118	ENSSARG00000010389	-	64	94.118	Sorex_araneus
ENSG00000124214	STAU1	99	88.978	ENSSPUG00000017983	STAU1	100	87.867	Sphenodon_punctatus
ENSG00000124214	STAU1	99	75.050	ENSSPAG00000019275	stau1	93	72.575	Stegastes_partitus
ENSG00000124214	STAU1	100	97.400	ENSSSCG00000027444	STAU1	100	97.400	Sus_scrofa
ENSG00000124214	STAU1	99	88.377	ENSTGUG00000008784	STAU1	93	87.305	Taeniopygia_guttata
ENSG00000124214	STAU1	99	75.252	ENSTRUG00000005837	stau1	93	75.538	Takifugu_rubripes
ENSG00000124214	STAU1	99	73.453	ENSTNIG00000014732	stau1	77	72.500	Tetraodon_nigroviridis
ENSG00000124214	STAU1	100	94.472	ENSTBEG00000009404	STAU1	100	83.218	Tupaia_belangeri
ENSG00000124214	STAU1	100	85.962	ENSTTRG00000004285	STAU1	100	85.962	Tursiops_truncatus
ENSG00000124214	STAU1	100	94.632	ENSUAMG00000025449	STAU1	100	94.632	Ursus_americanus
ENSG00000124214	STAU1	100	89.320	ENSUMAG00000024475	STAU1	89	92.857	Ursus_maritimus
ENSG00000124214	STAU1	100	97.400	ENSVPAG00000001313	STAU1	100	97.400	Vicugna_pacos
ENSG00000124214	STAU1	100	95.349	ENSVVUG00000022325	STAU1	100	95.349	Vulpes_vulpes
ENSG00000124214	STAU1	99	82.446	ENSXETG00000001783	stau1	96	82.643	Xenopus_tropicalis
ENSG00000124214	STAU1	95	64.583	ENSXCOG00000008804	stau1	83	66.061	Xiphophorus_couchianus
ENSG00000124214	STAU1	99	73.777	ENSXMAG00000016175	stau1	96	73.777	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0003725	double-stranded RNA binding	-	IEA	Function
GO:0005515	protein binding	15121898.15303970.15680326.19029303.20064372.22810585.22978549.23722113.23853584.25416956.26045787.28169297.	IPI	Function
GO:0005737	cytoplasm	19029303.22978549.	IDA	Component
GO:0005783	endoplasmic reticulum	23907398.	IDA	Component
GO:0005791	rough endoplasmic reticulum	-	IEA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005875	microtubule associated complex	10022909.	TAS	Component
GO:0005886	plasma membrane	22978549.	IDA	Component
GO:0008157	protein phosphatase 1 binding	-	IEA	Function
GO:0010494	cytoplasmic stress granule	-	ISS	Component
GO:0016020	membrane	19946888.	HDA	Component
GO:0016032	viral process	-	IEA	Process
GO:0030425	dendrite	15121898.	IDA	Component
GO:0034599	cellular response to oxidative stress	-	IEA	Process
GO:0036464	cytoplasmic ribonucleoprotein granule	15121898.	IDA	Component
GO:0043025	neuronal cell body	-	IEA	Component
GO:0044297	cell body	15121898.	IDA	Component
GO:0045070	positive regulation of viral genome replication	23907398.	IMP	Process
GO:0046726	positive regulation by virus of viral protein levels in host cell	23907398.	IMP	Process
GO:0070062	extracellular exosome	19199708.	HDA	Component
GO:0098978	glutamatergic synapse	-	IEA	Component
GO:0099010	modification of postsynaptic structure	-	IEA	Process
GO:1900273	positive regulation of long-term synaptic potentiation	-	IEA	Process