EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000124216 (Gene tree)
Gene ID: 6615
Gene Symbol: SNAI1
Alias: SNA|SLUGH2|SNAH|SNAIL1|SNAIL
Full Name: snail family transcriptional repressor 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 5,911 bases
Position: chr20:49,982,976-49,988,886
Accession: 11128
RBP type: canonical RBP
Summary: The Drosophila embryonic protein snail is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm. The nuclear protein encoded by this gene is structurally similar to the Drosophila snail protein, and is also thought to be critical for mesoderm formation in the developing embryo. At least two variants of a similar processed pseudogene have been found on chromosome 2. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000244050	zf-C2H2	PF00096.26	7.2e-16	1	2
ENSP00000244050	zf-C2H2	PF00096.26	7.2e-16	2	2
ENSP00000244050	zf-met	PF12874.7	5.7e-06	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
31131921	Small molecule inhibitors of epithelial-mesenchymal transition for the treatment of cancer and fibrosis.	Med Res Rev	2019 May 27	Feng YL	doi: 10.1002/med.21596
27682981	Identification of a Novel Human E-Cadherin Splice Variant and Assessment of Its Effects Upon EMT-Related Events.	J Cell Physiol	2017 Jun	Matos ML	doi: 10.1002/jcp.25622
28683467	RBM38 is involved in TGF-β-induced epithelial-to-mesenchymal transition by stabilising zonula occludens-1 mRNA in breast cancer.	Br J Cancer	2017 Aug 22	Wu J	doi: 10.1038/bjc.2017.204
25798844	miR-200 promotes the mesenchymal to epithelial transition by suppressing multiple members of the Zeb2 and Snail1 transcriptional repressor complexes.	Oncogene	2016 Jan 14	Perdigao-Henriques R	doi: 10.1038/onc.2015.69
31068593	Ribosome biogenesis during cell cycle arrest fuels EMT in development and disease.	Nat Commun	2019 May 8	Prakash V	doi: 10.1038/s41467-019-10100-8.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000244050	SNAI1-201	1686	-	ENSP00000244050	264 (aa)	-	O95863

Gene Model

Click here to download ENSG00000124216's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04520	Adherens junction	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000124216	Tunica Media	1.9630000E-005	-
ENSG00000124216	Psoriasis	2E-7	25903422
ENSG00000124216	Psoriasis	2E-6	25903422

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000124216's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000124216	SNAI1	99	48.592	ENSAPOG00000016426	-	99	46.809	Acanthochromis_polyacanthus
ENSG00000124216	SNAI1	98	50.746	ENSAPOG00000002867	snai1a	98	49.808	Acanthochromis_polyacanthus
ENSG00000124216	SNAI1	98	54.074	ENSAPOG00000003886	snai2	78	53.704	Acanthochromis_polyacanthus
ENSG00000124216	SNAI1	100	88.258	ENSAMEG00000013478	SNAI1	100	88.258	Ailuropoda_melanoleuca
ENSG00000124216	SNAI1	98	50.958	ENSACIG00000011318	snai1a	98	49.042	Amphilophus_citrinellus
ENSG00000124216	SNAI1	53	64.667	ENSACIG00000009443	-	99	46.953	Amphilophus_citrinellus
ENSG00000124216	SNAI1	98	54.982	ENSACIG00000018641	snai2	98	54.613	Amphilophus_citrinellus
ENSG00000124216	SNAI1	98	54.444	ENSAOCG00000017968	snai2	98	54.074	Amphiprion_ocellaris
ENSG00000124216	SNAI1	98	50.746	ENSAOCG00000018003	snai1a	98	50.763	Amphiprion_ocellaris
ENSG00000124216	SNAI1	98	54.444	ENSAPEG00000002983	snai2	98	54.074	Amphiprion_percula
ENSG00000124216	SNAI1	98	50.746	ENSAPEG00000024286	snai1a	98	50.763	Amphiprion_percula
ENSG00000124216	SNAI1	99	49.270	ENSAPEG00000007647	-	99	50.000	Amphiprion_percula
ENSG00000124216	SNAI1	99	48.929	ENSATEG00000004944	-	99	47.331	Anabas_testudineus
ENSG00000124216	SNAI1	98	54.815	ENSATEG00000006892	snai2	98	54.982	Anabas_testudineus
ENSG00000124216	SNAI1	98	50.558	ENSATEG00000015639	snai1a	98	50.575	Anabas_testudineus
ENSG00000124216	SNAI1	84	64.414	ENSAPLG00000014633	-	93	63.514	Anas_platyrhynchos
ENSG00000124216	SNAI1	98	52.347	ENSAPLG00000003920	-	99	52.536	Anas_platyrhynchos
ENSG00000124216	SNAI1	84	56.388	ENSACAG00000015607	SNAI1	87	56.388	Anolis_carolinensis
ENSG00000124216	SNAI1	98	51.748	ENSACAG00000012332	-	99	52.899	Anolis_carolinensis
ENSG00000124216	SNAI1	100	96.970	ENSANAG00000028666	SNAI1	100	96.970	Aotus_nancymaae
ENSG00000124216	SNAI1	99	47.601	ENSACLG00000026461	-	99	46.886	Astatotilapia_calliptera
ENSG00000124216	SNAI1	98	56.371	ENSACLG00000018551	snai2	98	55.598	Astatotilapia_calliptera
ENSG00000124216	SNAI1	98	51.852	ENSACLG00000020860	snai1a	98	50.370	Astatotilapia_calliptera
ENSG00000124216	SNAI1	98	55.390	ENSAMXG00000038235	snai2	98	53.546	Astyanax_mexicanus
ENSG00000124216	SNAI1	99	50.929	ENSAMXG00000039849	snai1b	99	50.746	Astyanax_mexicanus
ENSG00000124216	SNAI1	100	87.500	ENSBTAG00000014554	SNAI1	100	87.500	Bos_taurus
ENSG00000124216	SNAI1	53	50.360	WBGene00019299	snai-1	53	61.765	Caenorhabditis_elegans
ENSG00000124216	SNAI1	100	96.591	ENSCJAG00000000518	SNAI1	100	96.591	Callithrix_jacchus
ENSG00000124216	SNAI1	90	89.030	ENSCAFG00000011499	SNAI1	100	89.030	Canis_familiaris
ENSG00000124216	SNAI1	100	87.121	ENSCAFG00020017479	SNAI1	100	87.121	Canis_lupus_dingo
ENSG00000124216	SNAI1	100	87.500	ENSCHIG00000014308	SNAI1	100	87.500	Capra_hircus
ENSG00000124216	SNAI1	100	92.803	ENSTSYG00000010834	SNAI1	100	92.803	Carlito_syrichta
ENSG00000124216	SNAI1	95	85.714	ENSCAPG00000014002	SNAI1	95	85.714	Cavia_aperea
ENSG00000124216	SNAI1	100	90.152	ENSCPOG00000026663	SNAI1	100	90.152	Cavia_porcellus
ENSG00000124216	SNAI1	98	51.799	ENSCPOG00000033449	-	99	52.347	Cavia_porcellus
ENSG00000124216	SNAI1	100	97.727	ENSCCAG00000029550	SNAI1	100	97.727	Cebus_capucinus
ENSG00000124216	SNAI1	100	98.106	ENSCATG00000041452	SNAI1	100	98.106	Cercocebus_atys
ENSG00000124216	SNAI1	100	89.394	ENSCLAG00000012285	SNAI1	100	89.394	Chinchilla_lanigera
ENSG00000124216	SNAI1	100	98.106	ENSCSAG00000015065	SNAI1	100	98.106	Chlorocebus_sabaeus
ENSG00000124216	SNAI1	96	49.632	ENSCHOG00000007046	-	98	50.923	Choloepus_hoffmanni
ENSG00000124216	SNAI1	100	97.727	ENSCANG00000036400	SNAI1	100	97.727	Colobus_angolensis_palliatus
ENSG00000124216	SNAI1	100	87.121	ENSCGRG00001007749	Snai1	100	87.121	Cricetulus_griseus_chok1gshd
ENSG00000124216	SNAI1	100	87.121	ENSCGRG00000009080	Snai1	100	87.121	Cricetulus_griseus_crigri
ENSG00000124216	SNAI1	98	52.708	ENSCSEG00000010311	snai2	98	54.779	Cynoglossus_semilaevis
ENSG00000124216	SNAI1	98	49.091	ENSCSEG00000009739	snai1a	98	48.540	Cynoglossus_semilaevis
ENSG00000124216	SNAI1	99	50.000	ENSCVAG00000009930	-	99	50.000	Cyprinodon_variegatus
ENSG00000124216	SNAI1	98	52.158	ENSCVAG00000016483	snai2	99	51.590	Cyprinodon_variegatus
ENSG00000124216	SNAI1	98	49.265	ENSCVAG00000008717	snai1a	98	50.000	Cyprinodon_variegatus
ENSG00000124216	SNAI1	99	51.103	ENSDARG00000056995	snai1a	100	51.493	Danio_rerio
ENSG00000124216	SNAI1	99	50.558	ENSDARG00000046019	snai1b	99	49.815	Danio_rerio
ENSG00000124216	SNAI1	98	55.970	ENSDARG00000040046	snai2	98	54.104	Danio_rerio
ENSG00000124216	SNAI1	98	52.158	ENSDNOG00000035997	-	99	52.708	Dasypus_novemcinctus
ENSG00000124216	SNAI1	100	85.606	ENSDNOG00000023834	-	100	85.606	Dasypus_novemcinctus
ENSG00000124216	SNAI1	99	69.811	ENSDNOG00000024891	-	99	68.679	Dasypus_novemcinctus
ENSG00000124216	SNAI1	90	84.167	ENSDORG00000025372	Snai1	100	84.167	Dipodomys_ordii
ENSG00000124216	SNAI1	98	48.364	ENSETEG00000005777	-	99	49.091	Echinops_telfairi
ENSG00000124216	SNAI1	98	49.630	ENSEBUG00000011515	snai1a	82	48.315	Eptatretus_burgeri
ENSG00000124216	SNAI1	98	51.799	ENSEASG00005009186	-	99	52.347	Equus_asinus_asinus
ENSG00000124216	SNAI1	100	87.170	ENSECAG00000009787	SNAI1	100	87.170	Equus_caballus
ENSG00000124216	SNAI1	98	51.799	ENSECAG00000010120	SNAI2	99	52.347	Equus_caballus
ENSG00000124216	SNAI1	89	41.107	ENSELUG00000004844	snai1a	87	41.463	Esox_lucius
ENSG00000124216	SNAI1	99	49.470	ENSELUG00000002056	SNAI1	99	49.627	Esox_lucius
ENSG00000124216	SNAI1	98	51.439	ENSFCAG00000015779	-	99	51.986	Felis_catus
ENSG00000124216	SNAI1	100	86.742	ENSFCAG00000010558	SNAI1	100	86.742	Felis_catus
ENSG00000124216	SNAI1	98	52.347	ENSFALG00000005762	-	99	52.536	Ficedula_albicollis
ENSG00000124216	SNAI1	100	91.288	ENSFDAG00000005851	SNAI1	100	91.288	Fukomys_damarensis
ENSG00000124216	SNAI1	98	49.814	ENSFHEG00000018724	snai1a	98	49.808	Fundulus_heteroclitus
ENSG00000124216	SNAI1	98	53.704	ENSFHEG00000012561	snai2	98	53.333	Fundulus_heteroclitus
ENSG00000124216	SNAI1	98	48.188	ENSFHEG00000022095	-	99	47.482	Fundulus_heteroclitus
ENSG00000124216	SNAI1	96	48.031	ENSGMOG00000000127	-	99	46.899	Gadus_morhua
ENSG00000124216	SNAI1	96	49.813	ENSGMOG00000017815	snai1a	96	50.943	Gadus_morhua
ENSG00000124216	SNAI1	98	54.779	ENSGMOG00000002669	snai2	98	54.412	Gadus_morhua
ENSG00000124216	SNAI1	99	58.333	ENSGALG00000008018	SNAI1	99	58.333	Gallus_gallus
ENSG00000124216	SNAI1	98	50.187	ENSGALG00000030902	-	98	51.111	Gallus_gallus
ENSG00000124216	SNAI1	98	54.613	ENSGAFG00000021427	snai2	98	54.815	Gambusia_affinis
ENSG00000124216	SNAI1	98	49.446	ENSGAFG00000020143	snai1a	98	50.192	Gambusia_affinis
ENSG00000124216	SNAI1	99	49.466	ENSGAFG00000021126	-	99	48.772	Gambusia_affinis
ENSG00000124216	SNAI1	99	46.863	ENSGACG00000001618	-	97	45.865	Gasterosteus_aculeatus
ENSG00000124216	SNAI1	96	48.289	ENSGACG00000010147	snai1a	97	46.545	Gasterosteus_aculeatus
ENSG00000124216	SNAI1	98	51.601	ENSGACG00000017935	snai2	98	53.623	Gasterosteus_aculeatus
ENSG00000124216	SNAI1	84	60.088	ENSGAGG00000022705	SNAI1	87	60.177	Gopherus_agassizii
ENSG00000124216	SNAI1	100	98.864	ENSGGOG00000024422	SNAI1	100	98.864	Gorilla_gorilla
ENSG00000124216	SNAI1	98	51.852	ENSHBUG00000013491	snai1a	98	50.370	Haplochromis_burtoni
ENSG00000124216	SNAI1	98	56.371	ENSHBUG00000007764	snai2	98	55.598	Haplochromis_burtoni
ENSG00000124216	SNAI1	99	47.601	ENSHBUG00000005726	-	99	46.886	Haplochromis_burtoni
ENSG00000124216	SNAI1	98	51.799	ENSHGLG00000009439	SNAI2	99	52.347	Heterocephalus_glaber_female
ENSG00000124216	SNAI1	100	92.045	ENSHGLG00000005310	SNAI1	100	92.045	Heterocephalus_glaber_female
ENSG00000124216	SNAI1	98	51.799	ENSHGLG00100007484	SNAI2	99	52.347	Heterocephalus_glaber_male
ENSG00000124216	SNAI1	100	92.045	ENSHGLG00100018390	SNAI1	100	92.045	Heterocephalus_glaber_male
ENSG00000124216	SNAI1	98	50.000	ENSHCOG00000003407	snai1a	98	49.442	Hippocampus_comes
ENSG00000124216	SNAI1	98	50.368	ENSHCOG00000020556	-	99	50.000	Hippocampus_comes
ENSG00000124216	SNAI1	99	49.818	ENSIPUG00000015844	snai1b	99	50.185	Ictalurus_punctatus
ENSG00000124216	SNAI1	100	90.152	ENSSTOG00000005866	SNAI1	100	90.152	Ictidomys_tridecemlineatus
ENSG00000124216	SNAI1	100	85.985	ENSJJAG00000017317	Snai1	100	88.258	Jaculus_jaculus
ENSG00000124216	SNAI1	98	51.799	ENSJJAG00000017495	-	99	52.347	Jaculus_jaculus
ENSG00000124216	SNAI1	99	49.275	ENSKMAG00000018546	-	99	48.410	Kryptolebias_marmoratus
ENSG00000124216	SNAI1	98	53.933	ENSKMAG00000005164	snai2	98	54.613	Kryptolebias_marmoratus
ENSG00000124216	SNAI1	98	49.451	ENSKMAG00000021206	snai1a	98	49.624	Kryptolebias_marmoratus
ENSG00000124216	SNAI1	98	49.813	ENSLBEG00000017605	snai1a	98	49.064	Labrus_bergylta
ENSG00000124216	SNAI1	98	53.506	ENSLBEG00000000972	snai2	98	53.875	Labrus_bergylta
ENSG00000124216	SNAI1	99	48.763	ENSLBEG00000006963	-	99	47.101	Labrus_bergylta
ENSG00000124216	SNAI1	98	51.986	ENSLACG00000005413	snai2	99	53.480	Latimeria_chalumnae
ENSG00000124216	SNAI1	99	55.720	ENSLACG00000017707	SNAI1	99	53.759	Latimeria_chalumnae
ENSG00000124216	SNAI1	98	52.652	ENSLOCG00000004443	snai1a	98	52.692	Lepisosteus_oculatus
ENSG00000124216	SNAI1	100	85.227	ENSLAFG00000030265	SNAI1	100	85.227	Loxodonta_africana
ENSG00000124216	SNAI1	100	98.106	ENSMFAG00000000994	SNAI1	100	98.106	Macaca_fascicularis
ENSG00000124216	SNAI1	100	98.485	ENSMNEG00000036933	SNAI1	100	98.485	Macaca_nemestrina
ENSG00000124216	SNAI1	100	98.106	ENSMLEG00000039236	SNAI1	100	98.106	Mandrillus_leucophaeus
ENSG00000124216	SNAI1	98	54.982	ENSMAMG00000015632	snai2	98	54.613	Mastacembelus_armatus
ENSG00000124216	SNAI1	98	49.632	ENSMAMG00000020994	snai1a	98	49.446	Mastacembelus_armatus
ENSG00000124216	SNAI1	99	46.975	ENSMAMG00000010384	-	99	46.975	Mastacembelus_armatus
ENSG00000124216	SNAI1	99	47.601	ENSMZEG00005026596	-	99	46.886	Maylandia_zebra
ENSG00000124216	SNAI1	98	51.852	ENSMZEG00005010038	snai1a	98	50.370	Maylandia_zebra
ENSG00000124216	SNAI1	98	56.371	ENSMZEG00005025060	snai2	98	55.598	Maylandia_zebra
ENSG00000124216	SNAI1	98	52.347	ENSMGAG00000010813	-	99	52.536	Meleagris_gallopavo
ENSG00000124216	SNAI1	99	58.712	ENSMGAG00000009447	SNAI1	99	58.712	Meleagris_gallopavo
ENSG00000124216	SNAI1	100	87.879	ENSMAUG00000021592	Snai1	100	87.879	Mesocricetus_auratus
ENSG00000124216	SNAI1	98	52.555	ENSMICG00000000335	-	99	52.708	Microcebus_murinus
ENSG00000124216	SNAI1	100	93.561	ENSMICG00000042228	SNAI1	100	93.561	Microcebus_murinus
ENSG00000124216	SNAI1	100	89.015	ENSMOCG00000007847	Snai1	100	89.015	Microtus_ochrogaster
ENSG00000124216	SNAI1	98	49.815	ENSMMOG00000019965	snai1a	98	50.000	Mola_mola
ENSG00000124216	SNAI1	99	49.817	ENSMMOG00000020343	-	99	52.174	Mola_mola
ENSG00000124216	SNAI1	98	50.965	ENSMMOG00000016695	snai2	98	49.630	Mola_mola
ENSG00000124216	SNAI1	99	59.470	ENSMODG00000016309	SNAI1	99	56.489	Monodelphis_domestica
ENSG00000124216	SNAI1	98	57.143	ENSMALG00000021318	snai2	98	56.371	Monopterus_albus
ENSG00000124216	SNAI1	98	50.746	ENSMALG00000005785	snai1a	98	49.438	Monopterus_albus
ENSG00000124216	SNAI1	99	49.097	ENSMALG00000001010	-	99	48.339	Monopterus_albus
ENSG00000124216	SNAI1	100	87.879	MGP_CAROLIEiJ_G0024709	Snai1	100	87.879	Mus_caroli
ENSG00000124216	SNAI1	100	87.500	ENSMUSG00000042821	Snai1	100	87.500	Mus_musculus
ENSG00000124216	SNAI1	100	87.879	MGP_PahariEiJ_G0026151	Snai1	100	87.879	Mus_pahari
ENSG00000124216	SNAI1	100	87.879	MGP_SPRETEiJ_G0025629	Snai1	100	87.879	Mus_spretus
ENSG00000124216	SNAI1	100	87.879	ENSMPUG00000017558	SNAI1	100	87.879	Mustela_putorius_furo
ENSG00000124216	SNAI1	99	79.924	ENSMLUG00000011649	-	99	78.409	Myotis_lucifugus
ENSG00000124216	SNAI1	100	85.985	ENSMLUG00000015053	-	100	85.985	Myotis_lucifugus
ENSG00000124216	SNAI1	98	51.799	ENSNGAG00000009442	-	99	52.555	Nannospalax_galili
ENSG00000124216	SNAI1	100	89.015	ENSNGAG00000017185	Snai1	100	89.015	Nannospalax_galili
ENSG00000124216	SNAI1	63	62.275	ENSNBRG00000023091	snai1a	50	75.806	Neolamprologus_brichardi
ENSG00000124216	SNAI1	98	51.154	ENSNBRG00000003394	-	97	49.615	Neolamprologus_brichardi
ENSG00000124216	SNAI1	98	56.371	ENSNBRG00000011785	snai2	98	55.598	Neolamprologus_brichardi
ENSG00000124216	SNAI1	100	98.106	ENSNLEG00000006985	SNAI1	100	98.106	Nomascus_leucogenys
ENSG00000124216	SNAI1	98	51.799	ENSODEG00000003654	-	99	52.347	Octodon_degus
ENSG00000124216	SNAI1	99	88.302	ENSODEG00000007856	SNAI1	99	88.302	Octodon_degus
ENSG00000124216	SNAI1	98	54.444	ENSONIG00000009542	snai2	98	54.074	Oreochromis_niloticus
ENSG00000124216	SNAI1	98	51.111	ENSONIG00000020305	snai1a	98	49.630	Oreochromis_niloticus
ENSG00000124216	SNAI1	98	47.191	ENSONIG00000017451	-	98	46.468	Oreochromis_niloticus
ENSG00000124216	SNAI1	86	60.166	ENSOANG00000008681	SNAI1	91	59.751	Ornithorhynchus_anatinus
ENSG00000124216	SNAI1	91	88.285	ENSOCUG00000005422	SNAI1	98	88.285	Oryctolagus_cuniculus
ENSG00000124216	SNAI1	98	51.799	ENSOCUG00000012254	-	99	52.347	Oryctolagus_cuniculus
ENSG00000124216	SNAI1	98	53.091	ENSORLG00000017475	snai2	98	53.704	Oryzias_latipes
ENSG00000124216	SNAI1	98	50.185	ENSORLG00000023047	snai1a	98	50.379	Oryzias_latipes
ENSG00000124216	SNAI1	98	53.585	ENSORLG00020008787	snai2	98	53.704	Oryzias_latipes_hni
ENSG00000124216	SNAI1	98	50.373	ENSORLG00020019789	snai1a	98	50.575	Oryzias_latipes_hni
ENSG00000124216	SNAI1	98	50.185	ENSORLG00015015416	snai1a	98	50.379	Oryzias_latipes_hsok
ENSG00000124216	SNAI1	98	53.091	ENSORLG00015008609	snai2	98	53.704	Oryzias_latipes_hsok
ENSG00000124216	SNAI1	98	49.815	ENSOMEG00000023773	snai1a	98	50.379	Oryzias_melastigma
ENSG00000124216	SNAI1	98	54.340	ENSOMEG00000006591	snai2	98	53.962	Oryzias_melastigma
ENSG00000124216	SNAI1	98	51.799	ENSOGAG00000010500	-	99	52.347	Otolemur_garnettii
ENSG00000124216	SNAI1	100	94.697	ENSOGAG00000030111	SNAI1	100	94.697	Otolemur_garnettii
ENSG00000124216	SNAI1	94	84.615	ENSOARG00000013174	SNAI1	71	87.045	Ovis_aries
ENSG00000124216	SNAI1	100	98.485	ENSPPAG00000041096	SNAI1	100	98.485	Pan_paniscus
ENSG00000124216	SNAI1	100	86.742	ENSPPRG00000013272	SNAI1	100	86.742	Panthera_pardus
ENSG00000124216	SNAI1	100	98.485	ENSPTRG00000050285	SNAI1	100	98.485	Pan_troglodytes
ENSG00000124216	SNAI1	100	98.106	ENSPANG00000007536	SNAI1	100	98.106	Papio_anubis
ENSG00000124216	SNAI1	99	50.758	ENSPKIG00000006393	snai1a	99	51.661	Paramormyrops_kingsleyae
ENSG00000124216	SNAI1	99	57.993	ENSPSIG00000003607	SNAI1	99	57.678	Pelodiscus_sinensis
ENSG00000124216	SNAI1	98	48.315	ENSPMGG00000023198	snai1a	98	48.276	Periophthalmus_magnuspinnatus
ENSG00000124216	SNAI1	98	49.813	ENSPMGG00000006947	-	98	47.015	Periophthalmus_magnuspinnatus
ENSG00000124216	SNAI1	100	88.636	ENSPEMG00000023213	Snai1	100	88.636	Peromyscus_maniculatus_bairdii
ENSG00000124216	SNAI1	99	60.150	ENSPCIG00000023282	SNAI1	99	56.870	Phascolarctos_cinereus
ENSG00000124216	SNAI1	99	51.128	ENSPFOG00000008667	-	99	49.248	Poecilia_formosa
ENSG00000124216	SNAI1	98	53.704	ENSPFOG00000014336	snai2	98	54.444	Poecilia_formosa
ENSG00000124216	SNAI1	98	51.301	ENSPFOG00000015709	snai1a	98	51.527	Poecilia_formosa
ENSG00000124216	SNAI1	98	54.074	ENSPLAG00000009941	snai2	98	54.815	Poecilia_latipinna
ENSG00000124216	SNAI1	83	50.870	ENSPLAG00000011169	snai1a	53	73.846	Poecilia_latipinna
ENSG00000124216	SNAI1	99	50.545	ENSPLAG00000010605	-	99	48.375	Poecilia_latipinna
ENSG00000124216	SNAI1	98	49.077	ENSPMEG00000017260	snai1a	98	49.808	Poecilia_mexicana
ENSG00000124216	SNAI1	99	50.545	ENSPMEG00000007205	-	99	49.458	Poecilia_mexicana
ENSG00000124216	SNAI1	98	53.704	ENSPMEG00000024022	snai2	98	54.444	Poecilia_mexicana
ENSG00000124216	SNAI1	98	49.446	ENSPREG00000022303	snai1a	98	50.192	Poecilia_reticulata
ENSG00000124216	SNAI1	100	97.727	ENSPPYG00000011122	SNAI1	100	97.727	Pongo_abelii
ENSG00000124216	SNAI1	89	87.288	ENSPCAG00000011934	SNAI1	99	87.288	Procavia_capensis
ENSG00000124216	SNAI1	98	51.049	ENSPCAG00000001788	-	98	50.000	Procavia_capensis
ENSG00000124216	SNAI1	100	94.318	ENSPCOG00000020538	SNAI1	100	94.318	Propithecus_coquereli
ENSG00000124216	SNAI1	100	86.090	ENSPVAG00000004119	SNAI1	100	86.090	Pteropus_vampyrus
ENSG00000124216	SNAI1	98	56.371	ENSPNYG00000015217	snai2	98	55.598	Pundamilia_nyererei
ENSG00000124216	SNAI1	98	51.852	ENSPNYG00000018944	snai1a	98	50.370	Pundamilia_nyererei
ENSG00000124216	SNAI1	99	46.863	ENSPNYG00000001207	-	99	46.154	Pundamilia_nyererei
ENSG00000124216	SNAI1	98	54.779	ENSPNAG00000015896	snai2	98	53.992	Pygocentrus_nattereri
ENSG00000124216	SNAI1	99	52.416	ENSPNAG00000024123	snai1b	99	51.866	Pygocentrus_nattereri
ENSG00000124216	SNAI1	98	52.448	ENSRNOG00000047699	Snai2	99	52.708	Rattus_norvegicus
ENSG00000124216	SNAI1	100	89.015	ENSRNOG00000009594	Snai1	100	89.015	Rattus_norvegicus
ENSG00000124216	SNAI1	100	98.106	ENSRBIG00000026992	SNAI1	100	98.106	Rhinopithecus_bieti
ENSG00000124216	SNAI1	100	98.106	ENSRROG00000043753	SNAI1	100	98.106	Rhinopithecus_roxellana
ENSG00000124216	SNAI1	100	96.604	ENSSBOG00000034760	SNAI1	100	96.604	Saimiri_boliviensis_boliviensis
ENSG00000124216	SNAI1	99	60.526	ENSSHAG00000011015	SNAI1	99	57.252	Sarcophilus_harrisii
ENSG00000124216	SNAI1	99	52.222	ENSSFOG00015021578	snai1a	99	51.481	Scleropages_formosus
ENSG00000124216	SNAI1	98	50.746	ENSSMAG00000013652	snai1a	98	50.575	Scophthalmus_maximus
ENSG00000124216	SNAI1	98	52.536	ENSSMAG00000019364	snai2	98	54.244	Scophthalmus_maximus
ENSG00000124216	SNAI1	65	61.582	ENSSMAG00000008834	-	99	46.643	Scophthalmus_maximus
ENSG00000124216	SNAI1	99	49.110	ENSSDUG00000017250	-	99	48.000	Seriola_dumerili
ENSG00000124216	SNAI1	98	50.373	ENSSDUG00000019933	snai1a	98	49.064	Seriola_dumerili
ENSG00000124216	SNAI1	98	55.351	ENSSDUG00000018060	snai2	98	54.444	Seriola_dumerili
ENSG00000124216	SNAI1	98	56.923	ENSSLDG00000012852	snai2	98	56.154	Seriola_lalandi_dorsalis
ENSG00000124216	SNAI1	99	49.466	ENSSLDG00000025359	-	99	48.364	Seriola_lalandi_dorsalis
ENSG00000124216	SNAI1	98	50.373	ENSSLDG00000011412	snai1a	98	49.064	Seriola_lalandi_dorsalis
ENSG00000124216	SNAI1	99	55.056	ENSSPUG00000018057	SNAI1	99	52.632	Sphenodon_punctatus
ENSG00000124216	SNAI1	98	54.444	ENSSPAG00000022061	snai2	98	54.074	Stegastes_partitus
ENSG00000124216	SNAI1	98	50.000	ENSSPAG00000001874	snai1a	98	49.618	Stegastes_partitus
ENSG00000124216	SNAI1	99	49.104	ENSSPAG00000001098	-	99	47.163	Stegastes_partitus
ENSG00000124216	SNAI1	100	89.015	ENSSSCG00000032613	SNAI1	100	89.015	Sus_scrofa
ENSG00000124216	SNAI1	98	52.347	ENSTGUG00000010914	-	99	52.536	Taeniopygia_guttata
ENSG00000124216	SNAI1	99	57.471	ENSTGUG00000008724	SNAI1	99	57.471	Taeniopygia_guttata
ENSG00000124216	SNAI1	99	50.000	ENSTRUG00000000419	sna2	99	49.813	Takifugu_rubripes
ENSG00000124216	SNAI1	98	50.373	ENSTRUG00000022990	sna1	98	49.254	Takifugu_rubripes
ENSG00000124216	SNAI1	98	54.244	ENSTRUG00000025588	snai2	98	54.815	Takifugu_rubripes
ENSG00000124216	SNAI1	99	50.000	ENSTNIG00000003865	-	99	49.077	Tetraodon_nigroviridis
ENSG00000124216	SNAI1	98	50.000	ENSTNIG00000007311	snai1a	98	50.379	Tetraodon_nigroviridis
ENSG00000124216	SNAI1	98	53.455	ENSTNIG00000008504	snai2	98	54.444	Tetraodon_nigroviridis
ENSG00000124216	SNAI1	73	86.010	ENSTBEG00000012262	SNAI1	99	84.456	Tupaia_belangeri
ENSG00000124216	SNAI1	100	88.258	ENSTTRG00000002029	SNAI1	100	88.258	Tursiops_truncatus
ENSG00000124216	SNAI1	100	82.197	ENSUAMG00000026603	SNAI1	100	83.333	Ursus_americanus
ENSG00000124216	SNAI1	89	89.831	ENSUMAG00000024458	SNAI1	96	89.831	Ursus_maritimus
ENSG00000124216	SNAI1	100	87.121	ENSVVUG00000022410	SNAI1	100	87.121	Vulpes_vulpes
ENSG00000124216	SNAI1	99	56.985	ENSXETG00000027366	snai1	99	54.815	Xenopus_tropicalis
ENSG00000124216	SNAI1	98	54.074	ENSXCOG00000015084	snai2	98	54.815	Xiphophorus_couchianus
ENSG00000124216	SNAI1	98	49.815	ENSXCOG00000017528	snai1a	98	50.575	Xiphophorus_couchianus
ENSG00000124216	SNAI1	99	49.821	ENSXMAG00000015281	-	99	47.872	Xiphophorus_maculatus
ENSG00000124216	SNAI1	98	49.815	ENSXMAG00000027735	snai1a	98	50.575	Xiphophorus_maculatus
ENSG00000124216	SNAI1	98	53.704	ENSXMAG00000019030	snai2	98	54.444	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000122	negative regulation of transcription by RNA polymerase II	11912130.	IDA	Process
GO:0000122	negative regulation of transcription by RNA polymerase II	15314165.	IMP	Process
GO:0000122	negative regulation of transcription by RNA polymerase II	-	ISS	Process
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	11912130.	IDA	Function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	-	ISA	Function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	19274049.	NAS	Function
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	11912130.	IDA	Function
GO:0001649	osteoblast differentiation	20128911.	IEP	Process
GO:0001707	mesoderm formation	-	ISS	Process
GO:0001837	epithelial to mesenchymal transition	16096638.	IDA	Process
GO:0001837	epithelial to mesenchymal transition	-	ISS	Process
GO:0003180	aortic valve morphogenesis	20951801.	TAS	Process
GO:0003198	epithelial to mesenchymal transition involved in endocardial cushion formation	-	ISS	Process
GO:0003198	epithelial to mesenchymal transition involved in endocardial cushion formation	20951801.	TAS	Process
GO:0005515	protein binding	15448698.16096638.18331720.19411070.19955572.20385133.20389281.20562920.21577210.23644467.24209753.25203322.25314079.25416956.	IPI	Function
GO:0005634	nucleus	15448698.19955572.23288509.24209753.25893292.	IDA	Component
GO:0005634	nucleus	-	ISS	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005721	pericentric heterochromatin	24239292.	IDA	Component
GO:0005737	cytoplasm	15448698.19955572.24209753.	IDA	Component
GO:0005737	cytoplasm	-	ISS	Component
GO:0005829	cytosol	-	IDA	Component
GO:0010718	positive regulation of epithelial to mesenchymal transition	20018240.23288509.	IMP	Process
GO:0010718	positive regulation of epithelial to mesenchymal transition	-	ISS	Process
GO:0010718	positive regulation of epithelial to mesenchymal transition	17072303.	TAS	Process
GO:0010957	negative regulation of vitamin D biosynthetic process	19502595.	IDA	Process
GO:0016477	cell migration	-	IEA	Process
GO:0019900	kinase binding	15448698.	IPI	Function
GO:0030335	positive regulation of cell migration	15314165.20018240.	IMP	Process
GO:0031069	hair follicle morphogenesis	-	IEA	Process
GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator	15314165.	IMP	Process
GO:0045893	positive regulation of transcription, DNA-templated	20018240.	IMP	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0060021	roof of mouth development	-	IEA	Process
GO:0060536	cartilage morphogenesis	-	IEA	Process
GO:0060707	trophoblast giant cell differentiation	-	IEA	Process
GO:0060806	negative regulation of cell differentiation involved in embryonic placenta development	-	IEA	Process
GO:0060972	left/right pattern formation	-	IEA	Process
GO:0061314	Notch signaling involved in heart development	-	ISS	Process
GO:0061314	Notch signaling involved in heart development	20951801.	TAS	Process
GO:0070828	heterochromatin organization	-	ISS	Process
GO:0070888	E-box binding	11912130.	IDA	Function
GO:1902230	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	15314165.	IMP	Process
GO:2000810	regulation of bicellular tight junction assembly	15314165.	IMP	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
24721928	RhoGDI2 promotes epithelial-mesenchymal transition via induction of Snail in gastric cancer cells.	Oncotarget	2014 Mar 30	Cho HJ	-
24085291	Inhibition of Snail1-DNA-PKcs protein-protein interface sensitizes cancer cells and inhibits tumor metastasis.	J Biol Chem	2013 Nov 8	Kang GY	doi: 10.1074/jbc.M113.479840
28215642	CCL2 expression correlates with Snail expression and affects the prognosis of patients with gastric cancer.	Pathol Res Pract	2017 Mar	Zhang J	doi: 10.1016/j.prp.2016.12.013
29241546	Neutrophils and Snail Orchestrate the Establishment of a Pro-tumor Microenvironment in Lung Cancer.	Cell Rep	2017 Dec 12	Faget J	doi: 10.1016/j.celrep.2017.11.052.
29331416	Deubiquitinating enzyme PSMD14 promotes tumor metastasis through stabilizing SNAIL in human esophageal squamous cell carcinoma.	Cancer Lett	2018 Apr 1	Zhu R	doi: 10.1016/j.canlet.2018.01.025
26845447	Downregulation of tumor suppressing STF cDNA 3 promotes epithelial-mesenchymal transition and tumor metastasis of osteosarcoma by the Wnt/GSK-3β/β-catenin/Snail signaling pathway.	Cancer Lett	2016 Apr 10	Lv YF	doi: 10.1016/j.canlet.2016.01.046
18554584	Vascular endothelial growth factor-A stimulates Snail expression in breast tumor cells: implications for tumor progression.	Exp Cell Res	2008 Aug 1	Wanami LS	doi: 10.1016/j.yexcr.2008.05.004
22923499	Activation of the ATM-Snail pathway promotes breast cancer metastasis.	J Mol Cell Biol	2012 Oct	Sun M	doi: 10.1093/jmcb/mjs048
16568079	Expression of Snail protein in tumor-stroma interface.	Oncogene	2006 Aug 24	Franci C	-
23196056	Snail promotes Cyr61 secretion to prime collective cell migration and form invasive tumor nests in squamous cell carcinoma.	Cancer Lett	2013 Feb 28	Tanaka F	doi: 10.1016/j.canlet.2012.11.023
23449453	Mutual regulation between DNA-PKcs and Snail1 leads to increased genomic instability and aggressive tumor characteristics.	Cell Death Dis	2013 Feb 28	Pyun BJ	doi: 10.1038/cddis.2013.43.
25303734	Transcription factor snail regulates tumor necrosis factor α-mediated synovial fibroblast activation in the rheumatoid joint.	Arthritis Rheumatol	2015 Jan	Chen SY	doi: 10.1002/art.38899.
18043286	The E-cadherin repressor snail plays a role in tumor progression of endometrioid adenocarcinomas.	Diagn Mol Pathol	2007 Dec	Blechschmidt K	-
19795442	Snail is critical for tumor growth and metastasis of ovarian carcinoma.	Int J Cancer	2010 May 1	Jin H	doi: 10.1002/ijc.24901.
21448462	Implication of snail in metabolic stress-induced necrosis.	PLoS One	2011 Mar 23	Kim CH	doi: 10.1371/journal.pone.0018000.
25488750	Snail1-expressing fibroblasts in the tumor microenvironment display mechanical properties that support metastasis.	Cancer Res	2015 Jan 15	Stanisavljevic J	doi: 10.1158/0008-5472.CAN-14-1903
23761168	Snail cooperates with KrasG12D to promote pancreatic fibrosis.	Mol Cancer Res	2013 Sep	Shields MA	doi: 10.1158/1541-7786.MCR-12-0637
21839581	Pituitary tumor transforming gene induces epithelial to mesenchymal transition by regulation of Twist, Snail, Slug, and E-cadherin.	Cancer Lett	2011 Dec 1	Shah PP	doi: 10.1016/j.canlet.2011.06.033
24999604	Dysregulated expression of Snail and E-cadherin correlates with gastrointestinal stromal tumor metastasis.	Eur J Cancer Prev	2014 Sep	Liu S	doi: 10.1097/CEJ.0000000000000072.
19802011	SNAI1 expression in colon cancer related with CDH1 and VDR downregulation in normal adjacent tissue.	Oncogene	2009 Dec 10	Pena C	doi: 10.1038/onc.2009.285.
27706642	Snail-induced epithelial-mesenchymal transition in gastric carcinoma cells and generation of cancer stem cell characteristics.	Genet Mol Res	2016 Aug 29	Yang YJ	doi: 10.4238/gmr.15038510.
19887480	Snail promotes CXCR2 ligand-dependent tumor progression in non-small cell lung carcinoma.	Clin Cancer Res	2009 Nov 15	Yanagawa J	doi: 10.1158/1078-0432.CCR-09-1558
22791710	Protein kinase D1 mediates anchorage-dependent and -independent growth of tumor cells via the zinc finger transcription factor Snail1.	J Biol Chem	2012 Sep 21	Eiseler T	-
28400282	MicroRNA-153-3p suppress cell proliferation and invasion by targeting SNAI1 in melanoma.	Biochem Biophys Res Commun	2017 May 20	Zeng HF	doi: 10.1016/j.bbrc.2017.04.032
27503928	Snail1-Dependent Activation of Cancer-Associated Fibroblast Controls Epithelial Tumor Cell Invasion and Metastasis.	Cancer Res	2016 Nov 1	Alba-Castellon L	-
27705942	RND3 promotes Snail 1 protein degradation and inhibits glioblastoma cell migration and invasion.	Oncotarget	2016 Dec 13	Liu B	doi: 10.18632/oncotarget.12396.
21614180	Knockdown of snail sensitizes pancreatic cancer cells to chemotherapeutic agents and irradiation.	Int J Mol Sci	2010	Zhang K	doi: 10.3390/ijms11124891
23342249	Overexpression of snail induces epithelial-mesenchymal transition and a cancer stem cell-like phenotype in human colorectal cancer cells.	Cancer Med	2012 Aug	Fan F	doi: 10.1002/cam4.4
23973669	Snail/beta-catenin signaling protects breast cancer cells from hypoxia attack.	Exp Cell Res	2013 Dec 10	Scherbakov AM	doi: 10.1016/j.yexcr.2013.08.019
25681470	Hypoxia promotes HO-8910PM ovarian cancer cell invasion via Snail-mediated MT1-MMP upregulation.	Exp Biol Med (Maywood)	2015 Nov	Sun L	doi: 10.1177/1535370215570205
20397042	Snail regulates cell survival and inhibits cellular senescence in human metastatic prostate cancer cell lines.	Cell Biol Toxicol	2010 Dec	Emadi Baygi M	doi: 10.1007/s10565-010-9163-5
24354880	Effects of a functional variant c.353T>C in snai1 on risk of two contextual diseases. Chronic obstructive pulmonary disease and lung cancer.	Am J Respir Crit Care Med	2014 Jan 15	Yang L	doi: 10.1164/rccm.201307-1355OC.
28718374	Cancer-associated fibroblasts secrete FGF-1 to promote ovarian proliferation, migration, and invasion through the activation of FGF-1/FGFR4 signaling.	Tumour Biol	2017 Jul	Sun Y	doi: 10.1177/1010428317712592.
28176759	Snail reprograms glucose metabolism by repressing phosphofructokinase PFKP allowing cancer cell survival under metabolic stress.	Nat Commun	2017 Feb 8	Kim NH	doi: 10.1038/ncomms14374.
29703902	Snail promotes ovarian cancer progression by recruiting myeloid-derived suppressor cells via CXCR2 ligand upregulation.	Nat Commun	2018 Apr 27	Taki M	doi: 10.1038/s41467-018-03966-7.
30272327	Associations of genewide SNPs in SNAI1 and TWIST1 with breast cancer and ovarian cancer susceptibility among Chinese Han women.	Oncol Rep	2018 Dec	Wang YJ	doi: 10.3892/or.2018.6725
28687755	The integrated pathway of TGFβ/Snail with TNFα/NFκB may facilitate the tumor-stroma interaction in the EMT process and colorectal cancer prognosis.	Sci Rep	2017 Jul 7	Li H	doi: 10.1038/s41598-017-05280-6.
30569152	Upregulation of USP11 promotes epithelialtomesenchymal transition by deubiquitinating Snail in ovarian cancer.	Oncol Rep	2019 Mar	Wang W	doi: 10.3892/or.2018.6924
24402192	TWIST1 and SNAI1 as markers of poor prognosis in human colorectal cancer are associated with the expression of ALDH1 and TGF-β1.	Oncol Rep	2014 Mar	Kim YH	doi: 10.3892/or.2014.2970
24916398	Snail and Slug mediate tamoxifen resistance in breast cancer cells through activation of EGFR-ERK independent of epithelial-mesenchymal transition.	J Mol Cell Biol	2014 Aug	Jiang Y	doi: 10.1093/jmcb/mju019
22629832	[The role of transcription factor Snail1 in the regulation of hormonal sensitivity of in vitro cultured breast cancer cells].	Vopr Onkol	2012	Andreeva OE	-
22344746	SNAI1 overexpression induces stemness and promotes ovarian cancer cell invasion and metastasis.	Oncol Rep	2012 May	Lu ZY	doi: 10.3892/or.2012.1685
24565133	SNAI1 is critical for the aggressiveness of prostate cancer cells with low E-cadherin.	Mol Cancer	2014 Feb 24	Deep G	doi: 10.1186/1476-4598-13-37.
24333218	Acquisition of epithelial-mesenchymal transition phenotype and cancer stem cell-like properties in cisplatin-resistant lung cancer cells through AKT/β-catenin/Snail signaling pathway.	Eur J Pharmacol	2014 Jan 15	Wang H	doi: 10.1016/j.ejphar.2013.12.004
16169460	Of Snail, mice, and women.	Cancer Cell	2005 Sep	Davidson NE	-
19861116	Epithelial-mesenchymal transition with expression of SNAI1-induced chemoresistance in colorectal cancer.	Biochem Biophys Res Commun	2009 Dec 18	Hoshino H	doi: 10.1016/j.bbrc.2009.10.117
23979441	Hypoxia-induced snail expression through transcriptional regulation by HIF-1α in pancreatic cancer cells.	Dig Dis Sci	2013 Dec	Zhu GH	doi: 10.1007/s10620-013-2841-4
20543867	miR-661 expression in SNAI1-induced epithelial to mesenchymal transition contributes to breast cancer cell invasion by targeting Nectin-1 and StarD10 messengers.	Oncogene	2010 Aug 5	Vetter G	doi: 10.1038/onc.2010.181
15712635	The transcriptional repressor SNAIL is overexpressed in human colon cancer.	Dig Dis Sci	2005 Jan	Roy HK	-
25055044	Snail-regulated MiR-375 inhibits migration and invasion of gastric cancer cells by targeting JAK2.	PLoS One	2014 Jul 23	Xu Y	doi: 10.1371/journal.pone.0099516
25203322	PKD1 phosphorylation-dependent degradation of SNAIL by SCF-FBXO11 regulates epithelial-mesenchymal transition and metastasis.	Cancer Cell	2014 Sep 8	Zheng H	doi: 10.1016/j.ccr.2014.07.022.
19269083	Heregulin-beta1 promotes metastasis of breast cancer cell line SKBR3 through upregulation of Snail and induction of epithelial-mesenchymal transition.	Cancer Lett	2009 Jul 18	Cheng L	doi: 10.1016/j.canlet.2009.02.007
21796367	Co-expression of SNAIL and TWIST determines prognosis in estrogen receptor-positive early breast cancer patients.	Breast Cancer Res Treat	2012 May	van Nes JG	doi: 10.1007/s10549-011-1684-y
25164016	Transient SNAIL1 expression is necessary for metastatic competence in breast cancer.	Cancer Res	2014 Nov 1	Tran HD	doi: 10.1158/0008-5472.CAN-14-0923
18026186	The E-cadherin repressor Snail is associated with lower overall survival of ovarian cancer patients.	Br J Cancer	2008 Jan 29	Blechschmidt K	-
22006115	Temporal and spatial cooperation of Snail1 and Twist1 during epithelial-mesenchymal transition predicts for human breast cancer recurrence.	Mol Cancer Res	2011 Dec	Tran DD	doi: 10.1158/1541-7786.MCR-11-0371
22349639	Snail overexpression induces an epithelial to mesenchymal transition and cancer stem cell-like properties in SCC9 cells.	Lab Invest	2012 May	Zhu LF	doi: 10.1038/labinvest.2012.8
26771232	Dlx-2 and glutaminase upregulate epithelial-mesenchymal transition and glycolytic switch.	Oncotarget	2016 Feb 16	Lee SY	doi: 10.18632/oncotarget.6879.
20957493	Interaction of Snail and p38 mitogen-activated protein kinase results in shorter overall survival of ovarian cancer patients.	Virchows Arch	2010 Dec	Hipp S	doi: 10.1007/s00428-010-0986-5
21885439	Lung tumor-associated osteoblast-derived bone morphogenetic protein-2 increased epithelial-to-mesenchymal transition of cancer by Runx2/Snail signaling pathway.	J Biol Chem	2011 Oct 28	Hsu YL	doi: 10.1074/jbc.M111.256156
23791882	DYRK2 controls the epithelial-mesenchymal transition in breast cancer by degrading Snail.	Cancer Lett	2013 Oct 10	Mimoto R	doi: 10.1016/j.canlet.2013.06.005
20576520	SNAIL induces epithelial-to-mesenchymal transition in a human pancreatic cancer cell line (BxPC3) and promotes distant metastasis and invasiveness in vivo.	Exp Mol Pathol	2010 Oct	Nishioka R	doi: 10.1016/j.yexmp.2010.05.008
25122124	Snail promotes epithelial mesenchymal transition in breast cancer cells in part via activation of nuclear ERK2.	PLoS One	2014 Aug 14	Smith BN	doi: 10.1371/journal.pone.0104987
22307688	The relationships between snail1 and estrogen receptor signaling in breast cancer cells.	J Cell Biochem	2012 Jun	Scherbakov AM	doi: 10.1002/jcb.24087.
26498709	Snail-induced EMT promotes cancer stem cell-like properties in head and neck cancer cells.	Oncol Rep	2016 Jan	Ota I	doi: 10.3892/or.2015.4348
18234959	Transforming growth factor-beta 1 promotes matrix metalloproteinase-9-mediated oral cancer invasion through snail expression.	Mol Cancer Res	2008 Jan	Sun L	doi: 10.1158/1541-7786.MCR-07-0208.
24610352	Stabilization of Snail by HIF-1α and TNF-α is required for hypoxia-induced invasion in prostate cancer PC3 cells.	Mol Biol Rep	2014 Jul	Lv L	doi: 10.1007/s11033-014-3328-x
22471696	Snail is an independent prognostic predictor for progression and patient survival of gastric cancer.	Cancer Sci	2012 Jul	He H	doi: 10.1111/j.1349-7006.2012.02295.x
26840564	Tristetraprolin suppresses the EMT through the down-regulation of Twist1 and Snail1 in cancer cells.	Oncotarget	2016 Feb 23	Yoon NA	doi: 10.18632/oncotarget.7094.
25608841	Combined Runx2 and Snail overexpression is associated with a poor prognosis in breast cancer.	Tumour Biol	2015 Jun	Yang Z	doi: 10.1007/s13277-015-3101-3
17952120	Snail is a repressor of RKIP transcription in metastatic prostate cancer cells.	Oncogene	2008 Apr 3	Beach S	-
25088797	AKT/GSK-3β regulates stability and transcription of snail which is crucial for bFGF-induced epithelial-mesenchymal transition of prostate cancer cells.	Biochim Biophys Acta	2014 Oct	Liu ZC	doi: 10.1016/j.bbagen.2014.07.018
19046938	Tumor-induced upregulation of Twist, Snail, and Slug represses the activity of the human VE-cadherin promoter.	Arch Biochem Biophys	2009 Feb	Lopez D	doi: 10.1016/j.abb.2008.11.016
27455254	Akt Activation Correlates with Snail Expression and Potentially Determines the Recurrence of Prostate Cancer in Patients at Stage T2 after a Radical Prostatectomy.	Int J Mol Sci	2016 Jul 23	Chen WY	doi: 10.3390/ijms17081194.
22471493	Inhibition of invasion and metastasis of gastric cancer cells through snail targeting artificial microRNA interference.	Asian Pac J Cancer Prev	2011	Guo HM	-
20421926	Novel snail1 target proteins in human colon cancer identified by proteomic analysis.	PLoS One	2010 Apr 20	Larriba MJ	doi: 10.1371/journal.pone.0010221.
20403241	[Relationship between E-CD and Snail expressions and tumor invasion, metastasis and prognosis in colorectal cancer].	Zhonghua Zhong Liu Za Zhi	2010 Feb	Zheng BA	-
25019394	[The role of protein kinase PAK1 in the regulation of estrogen-independent growth of breast cancer].	Biomed Khim	2014 May-Jun	Avilova EA	-
25172658	Snail regulates the motility of oral cancer cells via RhoA/Cdc42/p-ERM pathway.	Biochem Biophys Res Commun	2014 Sep 26	Li YY	doi: 10.1016/j.bbrc.2014.08.110
22408413	Analysis of Snail-1, E-cadherin and claudin-1 expression in colorectal adenomas and carcinomas.	Int J Mol Sci	2012	Bezdekova M	doi: 10.3390/ijms13021632
23856093	VAV1 represses E-cadherin expression through the transactivation of Snail and Slug: a potential mechanism for aberrant epithelial to mesenchymal transition in human epithelial ovarian cancer.	Transl Res	2013 Sep	Wakahashi S	doi: 10.1016/j.trsl.2013.06.005
17072303	A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells.	Nat Cell Biol	2006 Dec	Yook JI	-
26510265	Snail transcript levels in diagnosis of pancreatic carcinoma with fine-needle aspirate.	Br J Biomed Sci	2015	Wang Z	-
22248055	The novel role of Yin Yang 1 in the regulation of epithelial to mesenchymal transition in cancer via the dysregulated NF-κB/Snail/YY1/RKIP/PTEN Circuitry.	Crit Rev Oncog	2011	Bonavida B	-
27495232	Quercetin modulates Wnt signaling components in prostate cancer cell line by inhibiting cell viability, migration, and metastases.	Tumour Biol	2016 Oct	Baruah MM	-
24648349	Differential effects of RUNX2 on the androgen receptor in prostate cancer: synergistic stimulation of a gene set exemplified by SNAI2 and subsequent invasiveness.	Cancer Res	2014 May 15	Little GH	doi: 10.1158/0008-5472.CAN-13-2003
24424718	Increased SNAIL expression and low syndecan levels are associated with high Gleason grade in prostate cancer.	Int J Oncol	2014 Mar	Poblete CE	doi: 10.3892/ijo.2014.2254
23431386	Epithelial-mesenchymal transition (EMT) induced by TNF-α requires AKT/GSK-3β-mediated stabilization of snail in colorectal cancer.	PLoS One	2013	Wang H	doi: 10.1371/journal.pone.0056664
27057280	CCL21 Facilitates Chemoresistance and Cancer Stem Cell-Like Properties of Colorectal Cancer Cells through AKT/GSK-3β/Snail Signals.	Oxid Med Cell Longev	2016	Lu LL	doi: 10.1155/2016/5874127
26701730	Altered expression of epithelial-to-mesenchymal transition proteins in extraprostatic prostate cancer.	Oncotarget	2016 Jan 12	Verrill C	doi: 10.18632/oncotarget.6689.
24878522	Snail interacts with hPLSCR1 promoter and down regulates its expression in IMR-32.	Biochem Biophys Res Commun	2014 Jul 18	Francis VG	doi: 10.1016/j.bbrc.2014.05.094
23435375	(V600E)BRAF promotes invasiveness of thyroid cancer cells by decreasing E-cadherin expression through a Snail-dependent mechanism.	Cancer Lett	2013 Jul 10	Baquero P	doi: 10.1016/j.canlet.2013.02.033
19915148	Induction of a MT1-MMP and MT2-MMP-dependent basement membrane transmigration program in cancer cells by Snail1.	Proc Natl Acad Sci U S A	2009 Dec 1	Ota I	doi: 10.1073/pnas.0910962106
25784376	Helicobacter pylori-induced epithelial-mesenchymal transition, a potential role of gastric cancer initiation and an emergence of stem cells.	Carcinogenesis	2015 May	Choi YJ	doi: 10.1093/carcin/bgv022
23054398	Inhibiting interactions of lysine demethylase LSD1 with snail/slug blocks cancer cell invasion.	Cancer Res	2013 Jan 1	Ferrari-Amorotti G	doi: 10.1158/0008-5472.CAN-12-1739
26110567	By inhibiting snail signaling and miR-23a-3p, osthole suppresses the EMT-mediated metastatic ability in prostate cancer.	Oncotarget	2015 Aug 28	Wen YC	-
23807662	SNAI1 protein expression is an independent negative prognosticator in muscle-invasive bladder cancer.	Ann Surg Oncol	2013 Oct	Keck B	doi: 10.1245/s10434-013-3075-6
23076049	The role of Snail in prostate cancer.	Cell Adh Migr	2012 Sep-Oct	Smith BN	doi: 10.4161/cam.21687
19245592	Snail1 is over-expressed in prostate cancer.	APMIS	2009 Mar	Heeboll S	doi: 10.1111/j.1600-0463.2008.00007.x.
25547433	RKIP promotes cisplatin-induced gastric cancer cell death through NF-κB/Snail pathway.	Tumour Biol	2015 Mar	Liu H	doi: 10.1007/s13277-014-2496-6
25975373	Expression and clinical significance of hypoxia-inducible factor 1α, Snail and E-cadherin in human ovarian cancer cell lines.	Mol Med Rep	2015 Sep	Zhang Y	doi: 10.3892/mmr.2015.3786
18676743	Epithelial-mesenchymal transition in cervical cancer: correlation with tumor progression, epidermal growth factor receptor overexpression, and snail up-regulation.	Clin Cancer Res	2008 Aug 1	Lee MY	doi: 10.1158/1078-0432.CCR-08-0234.
24242829	Protumorigenic effects of Snail-expression fibroblasts on colon cancer cells.	Int J Cancer	2014 Jun 15	Herrera A	doi: 10.1002/ijc.28613
24503443	Functional links between Snail-1 and Cx43 account for the recruitment of Cx43-positive cells into the invasive front of prostate cancer.	Carcinogenesis	2014 Sep	Ryszawy D	doi: 10.1093/carcin/bgu033
24489910	Snail contributes to the maintenance of stem cell-like phenotype cells in human pancreatic cancer.	PLoS One	2014 Jan 29	Zhou W	doi: 10.1371/journal.pone.0087409
18321996	Inhibition of CCN6 (Wnt-1-induced signaling protein 3) down-regulates E-cadherin in the breast epithelium through induction of snail and ZEB1.	Am J Pathol	2008 Apr	Huang W	doi: 10.2353/ajpath.2008.070899
23791009	The nuclear protein expression levels of SNAI1 and ZEB1 are involved in the progression and lymph node metastasis of cervical cancer via the epithelial-mesenchymal transition pathway.	Hum Pathol	2013 Oct	Chen Z	doi: 10.1016/j.humpath.2013.04.001
20166136	Snail transcription factor regulates neuroendocrine differentiation in LNCaP prostate cancer cells.	Prostate	2010 Jun 15	McKeithen D	doi: 10.1002/pros.21132.
26764010	Proteomic Analysis of Epithelial to Mesenchymal Transition (EMT) Reveals Cross-talk between SNAIL and HDAC1 Proteins in Breast Cancer Cells.	Mol Cell Proteomics	2016 Mar	Palma Cde S	doi: 10.1074/mcp.M115.052910
20138990	The transcription factors Snail1 and Snail2 repress vitamin D receptor during colon cancer progression.	J Steroid Biochem Mol Biol	2010 Jul	Larriba MJ	doi: 10.1016/j.jsbmb.2010.01.014
22974478	Snail promotes lymph node metastasis and Twist enhances tumor deposit formation through epithelial-mesenchymal transition in colorectal cancer.	Hum Pathol	2013 Feb	Fan XJ	doi: 10.1016/j.humpath.2012.03.029
26336990	The positive feedback between Snail and DAB2IP regulates EMT, invasion and metastasis in colorectal cancer.	Oncotarget	2015 Sep 29	Wang J	doi: 10.18632/oncotarget.4861.
27749822	Snail1-dependent p53 repression regulates expansion and activity of tumour-initiating cells in breast cancer.	Nat Cell Biol	2016 Nov	Ni T	doi: 10.1038/ncb3425
27878251	Glyceraldehyde-3-phosphate dehydrogenase promotes cancer growth and metastasis through upregulation of SNAIL expression.	Int J Oncol	2017 Jan	Liu K	doi: 10.3892/ijo.2016.3774
27554601	14-3-3ζ promotes lung cancer cell invasion by increasing the Snail protein expression through atypical protein kinase C (aPKC)/NF-κB signaling.	Exp Cell Res	2016 Oct 15	Tong S	doi: 10.1016/j.yexcr.2016.08.014
28299321	JianPi JieDu Recipe Inhibits Epithelial-to-Mesenchymal Transition in Colorectal Cancer through TGF-β/Smad Mediated Snail/E-Cadherin Expression.	Biomed Res Int	2017	Liu X	doi: 10.1155/2017/2613198
27504909	Enhancer decommissioning by Snail1-induced competitive displacement of TCF7L2 and down-regulation of transcriptional activators results in EPHB2 silencing.	Biochim Biophys Acta	2016 Nov	Schnappauf O	doi: 10.1016/j.bbagrm.2016.08.002
28259904	Silencing Snail suppresses tumor cell proliferation and invasion by reversing epithelial-to-mesenchymal transition and arresting G2/M phase in non-small cell lung cancer.	Int J Oncol	2017 Apr	Yang X	doi: 10.3892/ijo.2017.3888
27171242	Genetic Polymorphisms of TGFB1, TGFBR1, SNAI1 and TWIST1 Are Associated with Endometrial Cancer Susceptibility in Chinese Han Women.	PLoS One	2016 May 12	Yang L	doi: 10.1371/journal.pone.0155270
27461247	The clinical significance of snail protein expression in gastric cancer: a meta-analysis.	Hum Genomics	2016 Jul 25	Chen X	doi: 10.1186/s40246-016-0070-6.
27596137	MiR-137 and miR-34a directly target Snail and inhibit EMT, invasion and sphere-forming ability of ovarian cancer cells.	J Exp Clin Cancer Res	2016 Sep 5	Dong P	doi: 10.1186/s13046-016-0415-y.
28691764	Cten promotes epithelial-mesenchymal transition through the post-transcriptional stabilization of Snail.	Mol Carcinog	2017 Dec	Thorpe H	doi: 10.1002/mc.22704
27184007	Mouse double minute 2 (MDM2) upregulates Snail expression and induces epithelial-to-mesenchymal transition in breast cancer cells in vitro and in vivo.	Oncotarget	2016 Jun 14	Lu X	doi: 10.18632/oncotarget.9287.
27322434	SiRNA-mediated silencing of Snail-1 induces apoptosis and alters micro RNA expression in human urinary bladder cancer cell line.	Artif Cells Nanomed Biotechnol	2017 Aug	Musavi Shenas SMH	doi: 10.1080/21691401.2016.1198361
27409172	Snail promotes resistance to enzalutamide through regulation of androgen receptor activity in prostate cancer.	Oncotarget	2016 Aug 2	Ware KE	doi: 10.18632/oncotarget.10476.
28296173	Snail acetylation by histone acetyltransferase p300 in lung cancer.	Thorac Cancer	2017 May	Chang R	doi: 10.1111/1759-7714.12408
27566588	Role of RbBP5 and H3K4me3 in the vicinity of Snail transcription start site during epithelial-mesenchymal transition in prostate cancer cell.	Oncotarget	2016 Oct 4	Li D	doi: 10.18632/oncotarget.11549.
27894095	MicroRNA-182 drives colonization and macroscopic metastasis via targeting its suppressor SNAI1 in breast cancer.	Oncotarget	2017 Jan 17	Zhan Y	doi: 10.18632/oncotarget.13542.
27829223	EGF induces epithelial-mesenchymal transition through phospho-Smad2/3-Snail signaling pathway in breast cancer cells.	Oncotarget	2016 Dec 20	Kim J	doi: 10.18632/oncotarget.13116.
28498415	Downregulated connexin32 promotes EMT through the Wnt/β-catenin pathway by targeting Snail expression in hepatocellular carcinoma.	Int J Oncol	2017 Jun	Yang Y	doi: 10.3892/ijo.2017.3985
28424413	The SNAIL/miR-128 axis regulated growth, invasion, metastasis, and epithelial-to-mesenchymal transition of gastric cancer.	Oncotarget	2017 Jun 13	Yu WW	doi: 10.18632/oncotarget.16849.
28586004	COX-2 regulates Snail expression in gastric cancer via the Notch1 signaling pathway.	Int J Mol Med	2017 Aug	Ye Y	doi: 10.3892/ijmm.2017.3011
28849004	FoxM1 promotes epithelial-mesenchymal transition of hepatocellular carcinoma by targeting Snai1.	Mol Med Rep	2017 Oct	Yu CP	doi: 10.3892/mmr.2017.7223
28939076	Snail and Axin2 expression predict the malignant transformation of oral leukoplakia.	Oral Oncol	2017 Oct	Zhang X	doi: 10.1016/j.oraloncology.2017.08.004
28247164	Clinical significance of altering epithelial-mesenchymal transition in metastatic lymph nodes of gastric cancer.	Gastric Cancer	2017 Sep	Okubo K	doi: 10.1007/s10120-017-0705-x
29032338	An analysis of suppressing migratory effect on human urinary bladder cancer cell line by silencing of snail-1.	Biomed Pharmacother	2017 Dec	Salehi S	doi: 10.1016/j.biopha.2017.10.044
28925484	MiR-22 inhibits lung cancer cell EMT and invasion through targeting Snail.	Eur Rev Med Pharmacol Sci	2017 Aug	Zhang K	-
30058095	Chronic hypoxia-induced slug promotes invasive behavior of prostate cancer cells by activating expression of ephrin-B1.	Cancer Sci	2018 Oct	Iwasaki K	doi: 10.1111/cas.13754
28550287	Up-regulation of long non-coding RNA XLOC_010235 regulates epithelial-to-mesenchymal transition to promote metastasis by associating with Snail1 in gastric cancer.	Sci Rep	2017 May 26	Liu YY	doi: 10.1038/s41598-017-02254-6.
29355657	FBW7 loss promotes epithelial-to-mesenchymal transition in non-small cell lung cancer through the stabilization of Snail protein.	Cancer Lett	2018 Apr 10	Zhang Y	doi: 10.1016/j.canlet.2018.01.047
30189360	FOXF1 Induces Epithelial-Mesenchymal Transition in Colorectal Cancer Metastasis by Transcriptionally Activating SNAI1.	Neoplasia	2018 Oct	Wang S	doi: 10.1016/j.neo.2018.08.004
29475734	miR-145 Antagonizes SNAI1-Mediated Stemness and Radiation Resistance in Colorectal Cancer.	Mol Ther	2018 Mar 7	Zhu Y	doi: 10.1016/j.ymthe.2017.12.023
29661250	Isocitrate dehydrogenase 1-snail axis dysfunction significantly correlates with breast cancer prognosis and regulates cell invasion ability.	Breast Cancer Res	2018 Apr 16	Liu WS	doi: 10.1186/s13058-018-0953-7.
30502437	TRIM21 mediates ubiquitination of Snail and modulates epithelial to mesenchymal transition in breast cancer cells.	Int J Biol Macromol	2019 Mar 1	Jin Y	doi: 10.1016/j.ijbiomac.2018.11.269
30874360	DLL3 regulates the migration and invasion of small cell lung cancer by modulating Snail.	Cancer Sci	2019 May	Furuta M	doi: 10.1111/cas.13997

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr20	49987923	Missense_Mutation	novel	S221C	0.11	zf-C2H2
BLCA	chr20	49983003	5'UTR	novel		0.31
BLCA	chr20	49988040	Missense_Mutation	NA	S260L	0.52
BLCA	chr20	49984137	Missense_Mutation	novel	L132F	0.18
BRCA	chr20	49987919	Missense_Mutation	NA	R220C	0.31	zf-C2H2
BRCA	chr20	49987942	Silent	NA	L227L	0.15
BRCA	chr20	49987989	Missense_Mutation	NA	R243Q	0.29
BRCA	chr20	49988448	3'UTR	novel		0.38
CESC	chr20	49988571	3'UTR	novel		0.21
CESC	chr20	49987953	Nonsense_Mutation	NA	S231*	0.29
CESC	chr20	49988001	Missense_Mutation	NA	R247P	0.42
CESC	chr20	49984282	Missense_Mutation	rs369673182	V181I	0.37
CESC	chr20	49988062	3'UTR	rs374439062		0.19
CHOL	chr20	49988361	3'UTR	novel		0.35
COAD	chr20	49987988	Missense_Mutation	NA	R243W	0.42
COAD	chr20	49984300	Missense_Mutation	NA	K187E	0.48
COAD	chr20	49987874	Missense_Mutation	NA	E205K	0.23
COAD	chr20	49987920	Missense_Mutation	NA	R220H	0.14	zf-C2H2
COAD	chr20	49987874	Missense_Mutation	NA	E205K	0.1
ESCA	chr20	49988450	3'UTR	rs188628261		0.33
ESCA	chr20	49988135	3'UTR	novel		0.63
ESCA	chr20	49988450	3'UTR	rs188628261		0.21
ESCA	chr20	49984297	Missense_Mutation	novel	G186R	0.19
GBM	chr20	49988119	3'UTR	novel		0.89
HNSC	chr20	49984045	Frame_Shift_Del	novel	*S104Afs176**	0.1
LIHC	chr20	49983052	5'UTR	novel		0.1
LUAD	chr20	49983872	Missense_Mutation	novel	I44T	0.09
LUAD	chr20	49984141	Nonsense_Mutation	NA	Q134*	0.24
LUAD	chr20	49983918	Silent	rs369225838	L59L	0.3
LUAD	chr20	49987924	Silent	NA	S221S	0.15
LUAD	chr20	49984148	Missense_Mutation	NA	P136L	0.21
LUSC	chr20	49983932	Missense_Mutation	NA	V64D	0.37
LUSC	chr20	49983929	Missense_Mutation	NA	S63C	0.15
LUSC	chr20	49983889	Missense_Mutation	novel	L50F	0.16
LUSC	chr20	49988014	Frame_Shift_Del	novel	*H252Tfs28**	0.14
LUSC	chr20	49984111	Missense_Mutation	rs771035489	E124K	0.42
LUSC	chr20	49983881	Missense_Mutation	NA	P47L	0.4
OV	chr20	49987905	Missense_Mutation	rs768825298	R215H	0.54	zf-C2H2
OV	chr20	49988220	3'UTR	novel		0.15
OV	chr20	49983885	Missense_Mutation	NA	E48D	0.42
OV	chr20	49988042	Missense_Mutation	novel	G261R	0.06
READ	chr20	49987874	Missense_Mutation	NA	E205K	0.68
READ	chr20	49983061	Translation_Start_Site	novel	M1?	0.28
SARC	chr20	49983969	Silent	rs758694399	S76S	0.51
SARC	chr20	49984097	Missense_Mutation	novel	S119F	0.46
SARC	chr20	49984098	Silent	novel	S119S	0.45
SKCM	chr20	49983834	Missense_Mutation	NA	F31L	0.54
SKCM	chr20	49984085	Missense_Mutation	novel	S115F	0.33
SKCM	chr20	49984101	Silent	novel	S120S	0.24
SKCM	chr20	49984082	Missense_Mutation	rs774280694	S114F	0.08
SKCM	chr20	49984193	Missense_Mutation	novel	R151Q	0.64
SKCM	chr20	49984083	Silent	NA	S114S	0.2
SKCM	chr20	49984308	Missense_Mutation	NA	F189L	0.28
SKCM	chr20	49983929	Missense_Mutation	novel	S63F	0.36
SKCM	chr20	49988008	Silent	novel	S249S	0.46
SKCM	chr20	49984069	Missense_Mutation	rs754163516	P110S	0.46
SKCM	chr20	49988065	3'UTR	novel		0.33
STAD	chr20	49988052	Missense_Mutation	NA	R264H	0.26
STAD	chr20	49988052	Missense_Mutation	NA	R264H	0.39
STAD	chr20	49983844	Missense_Mutation	NA	Y35N	0.17
STAD	chr20	49988033	Missense_Mutation	rs151036730	G258S	0.11
STAD	chr20	49988087	3'UTR	novel		0.15
UCEC	chr20	49984340	Missense_Mutation	NA	R200Q	0.14
UCEC	chr20	49988010	Frame_Shift_Del	novel	*L250Rfs30**	0.09
UCEC	chr20	49987983	Missense_Mutation	novel	C241F	0.15
UCEC	chr20	49987914	Missense_Mutation	novel	A218V	0.24	zf-C2H2
UCEC	chr20	49983042	5'UTR	rs761929558		0.33
UCEC	chr20	49984262	Missense_Mutation	novel	R174Q	0.41
UCEC	chr20	49983837	Silent	novel	Q32Q	0.18
UCEC	chr20	49988118	3'UTR	novel		0.3
UCEC	chr20	49984192	Nonsense_Mutation	novel	R151*	0.25
UCEC	chr20	49984288	Missense_Mutation	rs544515729	G183R	0.29
UCEC	chr20	49987959	Missense_Mutation	novel	V233G	0.26
UCEC	chr20	49988147	3'UTR	novel		0.31
UCEC	chr20	49988573	3'UTR	novel		0.23
UCEC	chr20	49984244	Missense_Mutation	rs772006202	A168V	0.38
UCEC	chr20	49983974	Missense_Mutation	rs748041292	R78Q	0.35
UCEC	chr20	49983079	Missense_Mutation	novel	V7A	0.42
UCEC	chr20	49988331	3'UTR	rs186365987		0.38
UCEC	chr20	49987897	Missense_Mutation	NA	H212Q	0.31	zf-C2H2

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
LAML	DEL	0.0209	0.14746
LUAD	DEL	0.1008	0.18308
PRAD	AMP	0.0569	0.07085

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.005	Kaplan-Meier Survival Analysis
STAD	0.0089	Kaplan-Meier Survival Analysis
MESO	0.0046	Kaplan-Meier Survival Analysis
HNSC	0.047	Kaplan-Meier Survival Analysis
LUSC	0.00019	Kaplan-Meier Survival Analysis
ESCA	0.033	Kaplan-Meier Survival Analysis
KIRP	0.0044	Kaplan-Meier Survival Analysis
COAD	0.00031	Kaplan-Meier Survival Analysis
BLCA	0.004	Kaplan-Meier Survival Analysis
CESC	0.033	Kaplan-Meier Survival Analysis
READ	0.03	Kaplan-Meier Survival Analysis
UCEC	0.0059	Kaplan-Meier Survival Analysis
GBM	0.0027	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
THCA	0.001	Kaplan-Meier Survival Analysis
LUAD	0.011	Kaplan-Meier Survival Analysis
UVM	0.02	Kaplan-Meier Survival Analysis
OV	0.012	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Select Dataset :

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Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742