EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000124570 (Gene tree)
Gene ID: 5269
Gene Symbol: SERPINB6
Alias: PTI|CAP|PI6|DFNB91
Full Name: serpin family B member 6
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 24,007 bases
Position: chr6:2,948,159-2,972,165
Accession: 8950
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is a member of the serpin (serine proteinase inhibitor) superfamily, and ovalbumin(ov)-serpin subfamily. It was originally discovered as a placental thrombin inhibitor. The mouse homolog was found to be expressed in the hair cells of the inner ear. Mutations in this gene are associated with nonsyndromic progressive hearing loss, suggesting that this serpin plays an important role in the inner ear in the protection against leakage of lysosomal content during stress, and that loss of this protection results in cell death and sensorineural hearing loss. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2010]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000644178	SERPINB6-213	5620	XM_011514674	ENSP00000496073	376 (aa)	XP_011512976	P35237
ENST00000644388	SERPINB6-214	1494	-	ENSP00000494650	376 (aa)	-	P35237
ENST00000646775	SERPINB6-224	514	-	ENSP00000496225	17 (aa)	-	A0A2R8Y7E5
ENST00000380529	SERPINB6-204	1370	XM_024446464	ENSP00000369901	376 (aa)	XP_024302232	P35237
ENST00000647157	SERPINB6-225	3599	-	-	- (aa)	-	-
ENST00000616722	SERPINB6-208	2036	XM_011514672	ENSP00000481398	380 (aa)	XP_011512974	A0A024QZX5
ENST00000380520	SERPINB6-202	1313	-	ENSP00000369891	376 (aa)	-	P35237
ENST00000649845	SERPINB6-226	3489	-	ENSP00000497149	57 (aa)	-	-
ENST00000380524	SERPINB6-203	1495	-	ENSP00000369896	376 (aa)	-	P35237
ENST00000642543	SERPINB6-209	1384	XM_011514676	ENSP00000494161	332 (aa)	XP_011512978	A0A2R8YD12
ENST00000645580	SERPINB6-221	1565	-	ENSP00000495362	380 (aa)	-	A0A024QZX5
ENST00000335686	SERPINB6-201	1604	-	ENSP00000338358	376 (aa)	-	P35237
ENST00000644875	SERPINB6-219	536	-	ENSP00000494930	11 (aa)	-	A0A2R8Y5Y8
ENST00000645421	SERPINB6-220	477	-	ENSP00000496341	77 (aa)	-	A0A2R8Y517
ENST00000643227	SERPINB6-211	452	-	ENSP00000494217	77 (aa)	-	A0A2R8Y517
ENST00000646722	SERPINB6-223	2188	-	-	- (aa)	-	-
ENST00000646688	SERPINB6-222	489	-	ENSP00000494453	61 (aa)	-	A0A2R8YDD0
ENST00000612421	SERPINB6-207	1566	-	ENSP00000484343	395 (aa)	-	A0A087X1N8
ENST00000644697	SERPINB6-216	2120	-	-	- (aa)	-	-
ENST00000644693	SERPINB6-215	1467	-	ENSP00000495361	81 (aa)	-	A0A2R8Y6N4
ENST00000644777	SERPINB6-217	925	-	ENSP00000494783	60 (aa)	-	A0A2R8Y5S1
ENST00000380539	SERPINB6-205	1315	XM_017010940	ENSP00000369912	376 (aa)	XP_016866429	P35237
ENST00000644828	SERPINB6-218	1123	-	ENSP00000495086	171 (aa)	-	A0A2R8Y6A7
ENST00000643314	SERPINB6-212	3265	-	-	- (aa)	-	-
ENST00000643098	SERPINB6-210	1638	XM_024446462	ENSP00000493936	376 (aa)	XP_024302230	P35237
ENST00000380546	SERPINB6-206	1375	-	ENSP00000369919	376 (aa)	-	P35237

Gene Model

Click here to download ENSG00000124570's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa05146	Amoebiasis	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000124570	Leukemia, Lymphocytic, Chronic, B-Cell	2E-8	26956414

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000124570	rs73718779	6	2969044	A	Chronic lymphocytic leukemia	26956414	[1.16-1.36]	1.26	EFO_0000095

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000124570's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0002020	protease binding	14670919.17761692.	IPI	Function
GO:0004867	serine-type endopeptidase inhibitor activity	21873635.	IBA	Function
GO:0004867	serine-type endopeptidase inhibitor activity	17761692.	IDA	Function
GO:0005576	extracellular region	27068509.	HDA	Component
GO:0005615	extracellular space	21873635.	IBA	Component
GO:0005634	nucleus	14670919.	IDA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	14670919.17761692.20451170.	IDA	Component
GO:0005829	cytosol	8415716.	TAS	Component
GO:0005886	plasma membrane	-	TAS	Component
GO:0007605	sensory perception of sound	20451170.	IMP	Process
GO:0010951	negative regulation of endopeptidase activity	21873635.	IBA	Process
GO:0010951	negative regulation of endopeptidase activity	17761692.	IDA	Process
GO:0030667	secretory granule membrane	-	TAS	Component
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0062023	collagen-containing extracellular matrix	28344315.28675934.	HDA	Component
GO:0070062	extracellular exosome	19056867.23533145.	HDA	Component
GO:0070821	tertiary granule membrane	-	TAS	Component
GO:0071470	cellular response to osmotic stress	20451170.	IMP	Process
GO:0097180	serine protease inhibitor complex	17761692.	IDA	Component
GO:0101003	ficolin-1-rich granule membrane	-	TAS	Component