EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000124608 (Gene tree)
Gene ID: 57505
Gene Symbol: AARS2
Alias: KIAA1270|bA444E17.1|AARSL
Full Name: alanyl-tRNA synthetase 2, mitochondrial
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 15,533 bases
Position: chr6:44,297,826-44,313,358
Accession: 21022
RBP type: canonical RBP
Summary: The protein encoded by this gene belongs to the class-II aminoacyl-tRNA synthetase family. Aminoacyl-tRNA synthetases play critical roles in mRNA translation by charging tRNAs with their cognate amino acids. The encoded protein is a mitochondrial enzyme that specifically aminoacylates alanyl-tRNA. Mutations in this gene are a cause of combined oxidative phosphorylation deficiency 8. [provided by RefSeq, Dec 2011]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000244571	tRNA_SAD	PF07973.14	3.5e-08	1	1
ENSP00000244571	tRNA-synt_2c	PF01411.19	8.8e-174	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000244571	AARS2-201	3854	XM_005249245	ENSP00000244571	985 (aa)	XP_005249302	Q5JTZ9
ENST00000491573	AARS2-202	735	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000124608's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00970	Aminoacyl-tRNA biosynthesis	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000124608	Myocardial Infarction	5.8204984E-004	-
ENSG00000124608	Lipoprotein(a)	7.8520000E-005	-
ENSG00000124608	Erythrocyte Count	1.3880000E-005	-
ENSG00000124608	Erythrocyte Indices	5.5530000E-005	-
ENSG00000124608	Forced Expiratory Volume	5.5290000E-005	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000124608's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000124608	AARS2	96	45.924	ENSG00000090861	AARS	98	45.946

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000124608	AARS2	97	56.567	ENSAPOG00000016753	aars2	90	57.113	Acanthochromis_polyacanthus
ENSG00000124608	AARS2	99	85.642	ENSAMEG00000011742	AARS2	96	85.685	Ailuropoda_melanoleuca
ENSG00000124608	AARS2	97	56.760	ENSAOCG00000009057	aars2	95	57.323	Amphiprion_ocellaris
ENSG00000124608	AARS2	97	56.656	ENSAPEG00000018393	aars2	94	59.833	Amphiprion_percula
ENSG00000124608	AARS2	97	56.687	ENSATEG00000015094	aars2	98	56.687	Anabas_testudineus
ENSG00000124608	AARS2	93	60.734	ENSAPLG00000014835	AARS2	99	60.734	Anas_platyrhynchos
ENSG00000124608	AARS2	99	58.901	ENSACAG00000014588	AARS2	96	59.642	Anolis_carolinensis
ENSG00000124608	AARS2	92	93.826	ENSANAG00000019918	AARS2	100	96.000	Aotus_nancymaae
ENSG00000124608	AARS2	97	56.198	ENSACLG00000004009	aars2	91	56.198	Astatotilapia_calliptera
ENSG00000124608	AARS2	96	57.889	ENSAMXG00000032017	aars2	95	58.211	Astyanax_mexicanus
ENSG00000124608	AARS2	98	87.073	ENSBTAG00000013722	AARS2	98	87.073	Bos_taurus
ENSG00000124608	AARS2	100	93.503	ENSCJAG00000048207	AARS2	98	93.485	Callithrix_jacchus
ENSG00000124608	AARS2	98	87.423	ENSCAFG00000001989	AARS2	98	87.384	Canis_familiaris
ENSG00000124608	AARS2	98	87.423	ENSCAFG00020012236	AARS2	98	85.832	Canis_lupus_dingo
ENSG00000124608	AARS2	98	86.970	ENSCHIG00000018888	AARS2	98	86.970	Capra_hircus
ENSG00000124608	AARS2	100	88.426	ENSTSYG00000003694	AARS2	98	88.521	Carlito_syrichta
ENSG00000124608	AARS2	92	76.659	ENSCAPG00000011810	AARS2	100	76.659	Cavia_aperea
ENSG00000124608	AARS2	100	83.046	ENSCPOG00000009676	AARS2	98	83.144	Cavia_porcellus
ENSG00000124608	AARS2	98	93.175	ENSCCAG00000034130	AARS2	98	93.175	Cebus_capucinus
ENSG00000124608	AARS2	98	95.657	ENSCATG00000033744	AARS2	98	95.657	Cercocebus_atys
ENSG00000124608	AARS2	100	84.365	ENSCLAG00000014983	AARS2	98	85.005	Chinchilla_lanigera
ENSG00000124608	AARS2	98	95.657	ENSCSAG00000012446	AARS2	98	95.657	Chlorocebus_sabaeus
ENSG00000124608	AARS2	64	91.071	ENSCHOG00000009257	AARS2	69	91.071	Choloepus_hoffmanni
ENSG00000124608	AARS2	92	65.251	ENSCPBG00000025329	AARS2	100	65.251	Chrysemys_picta_bellii
ENSG00000124608	AARS2	61	41.429	ENSCING00000021413	-	99	41.374	Ciona_intestinalis
ENSG00000124608	AARS2	98	95.553	ENSCANG00000032282	AARS2	98	95.553	Colobus_angolensis_palliatus
ENSG00000124608	AARS2	98	83.814	ENSCGRG00001006954	Aars2	96	85.426	Cricetulus_griseus_chok1gshd
ENSG00000124608	AARS2	99	83.848	ENSCGRG00000007502	Aars2	96	85.426	Cricetulus_griseus_crigri
ENSG00000124608	AARS2	97	57.541	ENSCVAG00000006986	aars2	98	57.438	Cyprinodon_variegatus
ENSG00000124608	AARS2	96	56.309	ENSDARG00000107385	aars2	95	56.335	Danio_rerio
ENSG00000124608	AARS2	99	87.131	ENSDNOG00000019300	AARS2	98	85.892	Dasypus_novemcinctus
ENSG00000124608	AARS2	100	85.685	ENSDORG00000002088	Aars2	98	85.626	Dipodomys_ordii
ENSG00000124608	AARS2	96	33.784	FBgn0028962	AlaRS-m	98	33.593	Drosophila_melanogaster
ENSG00000124608	AARS2	92	77.147	ENSETEG00000017112	AARS2	91	77.147	Echinops_telfairi
ENSG00000124608	AARS2	73	47.411	ENSEBUG00000000531	aars2	98	47.376	Eptatretus_burgeri
ENSG00000124608	AARS2	98	88.247	ENSEASG00005003730	AARS2	99	88.211	Equus_asinus_asinus
ENSG00000124608	AARS2	98	88.041	ENSECAG00000024012	AARS2	99	88.108	Equus_caballus
ENSG00000124608	AARS2	92	85.915	ENSEEUG00000000927	AARS2	92	85.714	Erinaceus_europaeus
ENSG00000124608	AARS2	96	56.740	ENSELUG00000022923	aars2	95	56.768	Esox_lucius
ENSG00000124608	AARS2	98	88.108	ENSFCAG00000009773	AARS2	98	88.108	Felis_catus
ENSG00000124608	AARS2	92	61.438	ENSFALG00000011258	AARS2	100	61.438	Ficedula_albicollis
ENSG00000124608	AARS2	100	85.178	ENSFDAG00000018073	AARS2	98	85.109	Fukomys_damarensis
ENSG00000124608	AARS2	70	58.807	ENSFHEG00000001486	aars2	99	58.665	Fundulus_heteroclitus
ENSG00000124608	AARS2	90	59.589	ENSGMOG00000000274	AARS2	94	59.633	Gadus_morhua
ENSG00000124608	AARS2	97	59.814	ENSGALG00000035337	AARS2	99	61.188	Gallus_gallus
ENSG00000124608	AARS2	96	54.507	ENSGACG00000019994	aars2	99	54.593	Gasterosteus_aculeatus
ENSG00000124608	AARS2	99	64.350	ENSGAGG00000011276	AARS2	98	64.556	Gopherus_agassizii
ENSG00000124608	AARS2	100	98.782	ENSGGOG00000005517	AARS2	100	98.782	Gorilla_gorilla
ENSG00000124608	AARS2	100	83.858	ENSHGLG00000012340	AARS2	98	83.868	Heterocephalus_glaber_female
ENSG00000124608	AARS2	100	83.553	ENSHGLG00100004999	AARS2	98	83.557	Heterocephalus_glaber_male
ENSG00000124608	AARS2	97	58.075	ENSIPUG00000013115	aars2	94	58.930	Ictalurus_punctatus
ENSG00000124608	AARS2	98	86.867	ENSSTOG00000013499	AARS2	98	86.867	Ictidomys_tridecemlineatus
ENSG00000124608	AARS2	96	82.595	ENSJJAG00000015691	Aars2	98	82.213	Jaculus_jaculus
ENSG00000124608	AARS2	99	49.498	ENSKMAG00000010722	aars2	96	55.514	Kryptolebias_marmoratus
ENSG00000124608	AARS2	96	57.083	ENSLBEG00000023112	aars2	97	57.083	Labrus_bergylta
ENSG00000124608	AARS2	64	52.146	ENSLACG00000016975	aars2	99	52.335	Latimeria_chalumnae
ENSG00000124608	AARS2	99	55.601	ENSLOCG00000015678	aars2	96	56.429	Lepisosteus_oculatus
ENSG00000124608	AARS2	100	88.020	ENSLAFG00000014270	AARS2	98	88.211	Loxodonta_africana
ENSG00000124608	AARS2	98	95.657	ENSMFAG00000037353	AARS2	98	95.657	Macaca_fascicularis
ENSG00000124608	AARS2	98	95.657	ENSMMUG00000014387	AARS2	98	95.657	Macaca_mulatta
ENSG00000124608	AARS2	98	95.657	ENSMNEG00000029416	AARS2	98	95.657	Macaca_nemestrina
ENSG00000124608	AARS2	98	90.777	ENSMLEG00000035617	AARS2	98	90.693	Mandrillus_leucophaeus
ENSG00000124608	AARS2	97	56.508	ENSMAMG00000017622	aars2	95	56.962	Mastacembelus_armatus
ENSG00000124608	AARS2	78	58.119	ENSMZEG00005000526	aars2	97	58.119	Maylandia_zebra
ENSG00000124608	AARS2	89	60.405	ENSMGAG00000010762	AARS2	99	62.605	Meleagris_gallopavo
ENSG00000124608	AARS2	97	85.669	ENSMAUG00000015966	Aars2	96	86.596	Mesocricetus_auratus
ENSG00000124608	AARS2	98	88.728	ENSMICG00000013453	AARS2	98	88.728	Microcebus_murinus
ENSG00000124608	AARS2	98	84.124	ENSMOCG00000016383	Aars2	96	85.745	Microtus_ochrogaster
ENSG00000124608	AARS2	79	58.734	ENSMMOG00000018379	aars2	97	59.432	Mola_mola
ENSG00000124608	AARS2	99	75.302	ENSMODG00000018926	AARS2	95	76.471	Monodelphis_domestica
ENSG00000124608	AARS2	97	57.025	ENSMALG00000006474	aars2	97	57.025	Monopterus_albus
ENSG00000124608	AARS2	99	83.590	MGP_CAROLIEiJ_G0021643	Aars2	98	83.904	Mus_caroli
ENSG00000124608	AARS2	99	83.282	ENSMUSG00000023938	Aars2	98	83.593	Mus_musculus
ENSG00000124608	AARS2	99	83.179	MGP_PahariEiJ_G0020635	Aars2	98	83.489	Mus_pahari
ENSG00000124608	AARS2	99	83.487	MGP_SPRETEiJ_G0022555	Aars2	98	83.801	Mus_spretus
ENSG00000124608	AARS2	100	85.076	ENSMPUG00000012562	AARS2	96	85.109	Mustela_putorius_furo
ENSG00000124608	AARS2	99	88.501	ENSMLUG00000005280	AARS2	98	88.418	Myotis_lucifugus
ENSG00000124608	AARS2	99	85.626	ENSNGAG00000018985	Aars2	98	85.892	Nannospalax_galili
ENSG00000124608	AARS2	64	52.508	ENSNBRG00000021461	aars2	95	52.681	Neolamprologus_brichardi
ENSG00000124608	AARS2	86	96.716	ENSNLEG00000026583	AARS2	97	96.716	Nomascus_leucogenys
ENSG00000124608	AARS2	100	71.574	ENSMEUG00000014018	AARS2	98	72.257	Notamacropus_eugenii
ENSG00000124608	AARS2	78	91.453	ENSOPRG00000007693	AARS2	78	91.453	Ochotona_princeps
ENSG00000124608	AARS2	100	84.162	ENSODEG00000015674	AARS2	98	84.583	Octodon_degus
ENSG00000124608	AARS2	97	56.334	ENSONIG00000007337	aars2	99	53.189	Oreochromis_niloticus
ENSG00000124608	AARS2	97	84.271	ENSOCUG00000021422	AARS2	98	84.271	Oryctolagus_cuniculus
ENSG00000124608	AARS2	98	55.263	ENSORLG00000020897	aars2	97	55.852	Oryzias_latipes
ENSG00000124608	AARS2	97	55.441	ENSORLG00020022195	aars2	97	55.647	Oryzias_latipes_hni
ENSG00000124608	AARS2	60	60.167	ENSOMEG00000008126	aars2	95	60.000	Oryzias_melastigma
ENSG00000124608	AARS2	98	87.423	ENSOGAG00000008197	AARS2	98	87.487	Otolemur_garnettii
ENSG00000124608	AARS2	99	84.435	ENSOARG00000009761	AARS2	98	84.488	Ovis_aries
ENSG00000124608	AARS2	100	99.594	ENSPPAG00000011981	AARS2	100	99.594	Pan_paniscus
ENSG00000124608	AARS2	98	88.211	ENSPPRG00000016970	AARS2	98	88.211	Panthera_pardus
ENSG00000124608	AARS2	98	87.177	ENSPTIG00000009040	AARS2	98	87.177	Panthera_tigris_altaica
ENSG00000124608	AARS2	100	99.695	ENSPTRG00000018222	AARS2	100	99.695	Pan_troglodytes
ENSG00000124608	AARS2	98	95.756	ENSPANG00000004773	AARS2	98	95.760	Papio_anubis
ENSG00000124608	AARS2	95	57.323	ENSPKIG00000022026	aars2	95	57.354	Paramormyrops_kingsleyae
ENSG00000124608	AARS2	92	64.629	ENSPSIG00000018093	AARS2	99	64.629	Pelodiscus_sinensis
ENSG00000124608	AARS2	81	50.985	ENSPMGG00000017827	aars2	83	50.249	Periophthalmus_magnuspinnatus
ENSG00000124608	AARS2	98	79.691	ENSPEMG00000022933	Aars2	96	80.957	Peromyscus_maniculatus_bairdii
ENSG00000124608	AARS2	76	54.628	ENSPMAG00000000127	aars2	95	54.416	Petromyzon_marinus
ENSG00000124608	AARS2	100	75.730	ENSPCIG00000024045	AARS2	98	76.103	Phascolarctos_cinereus
ENSG00000124608	AARS2	96	57.785	ENSPFOG00000018686	aars2	95	57.895	Poecilia_formosa
ENSG00000124608	AARS2	91	67.857	ENSPLAG00000005223	aars2	96	86.111	Poecilia_latipinna
ENSG00000124608	AARS2	96	58.142	ENSPMEG00000019241	aars2	97	58.254	Poecilia_mexicana
ENSG00000124608	AARS2	72	61.111	ENSPREG00000005915	aars2	93	61.752	Poecilia_reticulata
ENSG00000124608	AARS2	92	98.236	ENSPPYG00000016659	AARS2	100	98.236	Pongo_abelii
ENSG00000124608	AARS2	70	88.043	ENSPCAG00000003017	AARS2	68	88.043	Procavia_capensis
ENSG00000124608	AARS2	98	89.555	ENSPCOG00000024458	AARS2	98	89.555	Propithecus_coquereli
ENSG00000124608	AARS2	95	86.896	ENSPVAG00000004577	AARS2	98	87.295	Pteropus_vampyrus
ENSG00000124608	AARS2	97	54.472	ENSPNYG00000016666	aars2	97	58.257	Pundamilia_nyererei
ENSG00000124608	AARS2	99	56.562	ENSPNAG00000027249	aars2	94	57.962	Pygocentrus_nattereri
ENSG00000124608	AARS2	92	84.785	ENSRNOG00000025808	Aars2	100	84.785	Rattus_norvegicus
ENSG00000124608	AARS2	98	95.967	ENSRBIG00000028209	AARS2	98	95.967	Rhinopithecus_bieti
ENSG00000124608	AARS2	98	94.737	ENSRROG00000031944	AARS2	100	95.810	Rhinopithecus_roxellana
ENSG00000124608	AARS2	100	92.386	ENSSBOG00000018590	AARS2	98	92.658	Saimiri_boliviensis_boliviensis
ENSG00000124608	AARS2	100	75.126	ENSSHAG00000017514	AARS2	98	75.565	Sarcophilus_harrisii
ENSG00000124608	AARS2	99	55.600	ENSSFOG00015022513	aars2	94	56.992	Scleropages_formosus
ENSG00000124608	AARS2	97	56.553	ENSSMAG00000021048	aars2	97	56.321	Scophthalmus_maximus
ENSG00000124608	AARS2	97	56.598	ENSSDUG00000021596	aars2	97	56.598	Seriola_dumerili
ENSG00000124608	AARS2	88	53.034	ENSSLDG00000022728	aars2	96	52.921	Seriola_lalandi_dorsalis
ENSG00000124608	AARS2	84	61.684	ENSSPUG00000017621	AARS2	94	63.073	Sphenodon_punctatus
ENSG00000124608	AARS2	97	56.450	ENSSPAG00000016867	aars2	95	57.007	Stegastes_partitus
ENSG00000124608	AARS2	97	86.464	ENSSSCG00000001706	AARS2	98	82.627	Sus_scrofa
ENSG00000124608	AARS2	98	61.105	ENSTGUG00000007880	AARS2	97	61.830	Taeniopygia_guttata
ENSG00000124608	AARS2	98	54.629	ENSTRUG00000013248	aars2	98	55.190	Takifugu_rubripes
ENSG00000124608	AARS2	87	92.398	ENSTBEG00000016385	AARS2	85	92.398	Tupaia_belangeri
ENSG00000124608	AARS2	100	87.310	ENSTTRG00000006938	AARS2	98	87.280	Tursiops_truncatus
ENSG00000124608	AARS2	95	78.326	ENSUMAG00000005248	AARS2	89	88.227	Ursus_maritimus
ENSG00000124608	AARS2	99	87.577	ENSVVUG00000029231	AARS2	98	87.487	Vulpes_vulpes
ENSG00000124608	AARS2	96	56.590	ENSXMAG00000008742	aars2	96	56.540	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000049	tRNA binding	21873635.	IBA	Function
GO:0004813	alanine-tRNA ligase activity	21873635.	IBA	Function
GO:0004813	alanine-tRNA ligase activity	21549344.	IMP	Function
GO:0005524	ATP binding	21873635.	IBA	Function
GO:0005739	mitochondrion	21549344.	IDA	Component
GO:0006400	tRNA modification	21873635.	IBA	Process
GO:0006419	alanyl-tRNA aminoacylation	21873635.	IBA	Process
GO:0008270	zinc ion binding	-	IEA	Function
GO:0016597	amino acid binding	21873635.	IBA	Function
GO:0033108	mitochondrial respiratory chain complex assembly	21549344.	IMP	Process
GO:0070143	mitochondrial alanyl-tRNA aminoacylation	21873635.	IBA	Process
GO:0070143	mitochondrial alanyl-tRNA aminoacylation	21549344.	IMP	Process