EuRBPDB

Description

Ensembl ID: ENSG00000124783 (Gene tree)
Gene ID: 6745
Gene Symbol: SSR1
Alias: TRAPA
Full Name: signal sequence receptor subunit 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 79,141 bases
Position: chr6:7,268,306-7,347,446
Accession: 11323
RBP type: non-canonical RBP
Summary: The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein encoded by this gene and a 22-kD glycoprotein. This gene generates several mRNA species as a result of complex alternative polyadenylation. This gene is unusual in that it utilizes arrays of polyA signal sequences that are mostly non-canonical. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
8385931	Intracellular Ca2+ stores of rat cerebellum: heterogeneity within and distinction from endoplasmic reticulum.	Biochem J	1993 Apr 1	Nori A	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000397511	SSR1-202	3248	-	ENSP00000380647	291 (aa)	-	E9PAL7
ENST00000483409	SSR1-208	570	-	-	- (aa)	-	-
ENST00000475213	SSR1-205	446	-	-	- (aa)	-	-
ENST00000462112	SSR1-203	1094	-	ENSP00000417290	265 (aa)	-	C9J3L8
ENST00000479485	SSR1-207	640	-	ENSP00000419953	103 (aa)	-	C9JY01
ENST00000479365	SSR1-206	1118	-	ENSP00000417911	266 (aa)	-	C9J5W0
ENST00000489567	SSR1-210	1893	-	ENSP00000420730	218 (aa)	-	C9JBX5
ENST00000650389	SSR1-211	1640	-	ENSP00000497016	288 (aa)	-	-
ENST00000244763	SSR1-201	9669	-	ENSP00000244763	286 (aa)	-	P43307
ENST00000474597	SSR1-204	1808	-	ENSP00000418617	298 (aa)	-	C9IZQ1
ENST00000488834	SSR1-209	585	-	-	- (aa)	-	-

Gene Model

Pathways

Pathway ID	Pathway Name	Source
hsa04141	Protein processing in endoplasmic reticulum	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000124783	Platelet Function Tests	2.3432800E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000124783	rs9505118	6	7290204	G	Type 2 diabetes	28869590	[0.028-0.06] unit decrease	0.044	EFO_0001360
ENSG00000124783	rs9505118	6	7290204	G	Type 2 diabetes	28869590	[0.042-0.083] unit decrease	0.0626	EFO_0001360
ENSG00000124783	rs144370238	6	7317250	T	Spherical equivalent or myopia (age of diagnosis)	29808027	[NR] z score decrease	6.046	EFO_0004847\|HP_0000545\|EFO_0007814
ENSG00000124783	rs1050226	6	7281421	G	Type 2 diabetes	30054458	[0.035-0.064] unit decrease	0.0491	EFO_0001360
ENSG00000124783	rs35911902	6	7315330	?	White blood cell count	30595370			EFO_0004308

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000124783	SSR1	100	48.598	FBgn0028327	l(1)G0320	84	43.083	Drosophila_melanogaster
ENSG00000124783	SSR1	100	98.058	ENSMUSG00000021427	Ssr1	96	94.737	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005515	protein binding	17380188.22314232.29568061.	IPI	Function
GO:0005783	endoplasmic reticulum	21873635.	IBA	Component
GO:0005783	endoplasmic reticulum	-	IDA	Component
GO:0005789	endoplasmic reticulum membrane	-	TAS	Component
GO:0006613	cotranslational protein targeting to membrane	8050590.	TAS	Process
GO:0008284	positive regulation of cell proliferation	10437777.	TAS	Process
GO:0016021	integral component of membrane	-	IEA	Component
GO:0036498	IRE1-mediated unfolded protein response	-	TAS	Process