EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000124784 (Gene tree)
Gene ID: 83732
Gene Symbol: RIOK1
Alias: AD034|FLJ30006|bA288G3.1|RRP10
Full Name: RIO kinase 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 28,619 bases
Position: chr6:7,389,419-7,418,037
Accession: 18656
RBP type: canonical RBP
Summary: The protein encoded by this gene competes with pICln for inclusion in the protein arginine methyltransferase 5 complex. This complex targets substrates for dimethylation. The encoded protein is essential for the last steps in the maturation of 40S subunits. [provided by RefSeq, Jan 2017]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000369162	RIO1	PF01163.22	3.2e-77	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
21081503	RioK1, a new interactor of protein arginine methyltransferase 5 (PRMT5), competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity.	J Biol Chem	2011 Jan 21	Guderian G	doi: 10.1074/jbc.M110.148486

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000475351	RIOK1-203	960	-	ENSP00000418263	95 (aa)	-	E9PFQ8
ENST00000493691	RIOK1-205	310	-	-	- (aa)	-	-
ENST00000484626	RIOK1-204	499	-	-	- (aa)	-	-
ENST00000264874	RIOK1-201	1988	-	-	- (aa)	-	-
ENST00000379834	RIOK1-202	2810	XM_011514933	ENSP00000369162	568 (aa)	XP_011513235	Q9BRS2

Gene Model

Click here to download ENSG00000124784's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03008	Ribosome biogenesis in eukaryotes	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000124784's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000124784	RIOK1	53	43.131	ENSG00000101782	RIOK3	90	41.250

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000124784	RIOK1	57	66.667	ENSAPOG00000015632	riok1	99	66.667	Acanthochromis_polyacanthus
ENSG00000124784	RIOK1	100	89.807	ENSAMEG00000017367	RIOK1	100	89.104	Ailuropoda_melanoleuca
ENSG00000124784	RIOK1	88	70.659	ENSACIG00000003735	riok1	85	72.746	Amphilophus_citrinellus
ENSG00000124784	RIOK1	99	66.132	ENSAOCG00000011818	riok1	100	66.257	Amphiprion_ocellaris
ENSG00000124784	RIOK1	99	66.607	ENSAPEG00000001345	riok1	100	66.316	Amphiprion_percula
ENSG00000124784	RIOK1	82	71.274	ENSATEG00000006594	riok1	99	71.274	Anabas_testudineus
ENSG00000124784	RIOK1	84	82.773	ENSAPLG00000004196	RIOK1	100	83.613	Anas_platyrhynchos
ENSG00000124784	RIOK1	100	77.193	ENSACAG00000000695	RIOK1	100	76.316	Anolis_carolinensis
ENSG00000124784	RIOK1	97	93.478	ENSANAG00000023777	RIOK1	100	87.324	Aotus_nancymaae
ENSG00000124784	RIOK1	99	66.667	ENSACLG00000015799	riok1	99	66.312	Astatotilapia_calliptera
ENSG00000124784	RIOK1	99	68.096	ENSAMXG00000015286	riok1	84	75.911	Astyanax_mexicanus
ENSG00000124784	RIOK1	100	88.732	ENSBTAG00000013821	RIOK1	100	88.732	Bos_taurus
ENSG00000124784	RIOK1	78	48.115	WBGene00019698	riok-1	77	49.767	Caenorhabditis_elegans
ENSG00000124784	RIOK1	100	96.831	ENSCJAG00000042960	RIOK1	100	96.831	Callithrix_jacchus
ENSG00000124784	RIOK1	100	88.928	ENSCAFG00000009563	RIOK1	100	88.928	Canis_familiaris
ENSG00000124784	RIOK1	97	86.207	ENSCAFG00020013233	RIOK1	99	86.388	Canis_lupus_dingo
ENSG00000124784	RIOK1	100	87.676	ENSCHIG00000001534	RIOK1	100	87.676	Capra_hircus
ENSG00000124784	RIOK1	66	90.451	ENSTSYG00000011368	RIOK1	100	93.884	Carlito_syrichta
ENSG00000124784	RIOK1	79	89.778	ENSCAPG00000008489	RIOK1	100	89.871	Cavia_aperea
ENSG00000124784	RIOK1	98	86.691	ENSCPOG00000009882	RIOK1	100	87.193	Cavia_porcellus
ENSG00000124784	RIOK1	100	97.359	ENSCCAG00000024061	RIOK1	100	97.359	Cebus_capucinus
ENSG00000124784	RIOK1	100	96.831	ENSCATG00000001548	RIOK1	100	96.831	Cercocebus_atys
ENSG00000124784	RIOK1	100	90.861	ENSCLAG00000003522	RIOK1	100	90.861	Chinchilla_lanigera
ENSG00000124784	RIOK1	94	96.241	ENSCSAG00000007396	RIOK1	98	96.241	Chlorocebus_sabaeus
ENSG00000124784	RIOK1	97	71.739	ENSCHOG00000001873	RIOK1	85	79.560	Choloepus_hoffmanni
ENSG00000124784	RIOK1	94	76.173	ENSCPBG00000008685	RIOK1	91	76.296	Chrysemys_picta_bellii
ENSG00000124784	RIOK1	100	97.183	ENSCANG00000032919	RIOK1	100	97.183	Colobus_angolensis_palliatus
ENSG00000124784	RIOK1	100	82.074	ENSCGRG00001018868	Riok1	100	81.162	Cricetulus_griseus_chok1gshd
ENSG00000124784	RIOK1	100	82.074	ENSCGRG00000008015	Riok1	100	81.162	Cricetulus_griseus_crigri
ENSG00000124784	RIOK1	88	50.696	ENSCSEG00000015014	riok1	86	51.008	Cynoglossus_semilaevis
ENSG00000124784	RIOK1	57	64.417	ENSCVAG00000011291	riok1	99	64.417	Cyprinodon_variegatus
ENSG00000124784	RIOK1	99	68.972	ENSDARG00000016399	riok1	100	69.326	Danio_rerio
ENSG00000124784	RIOK1	100	86.736	ENSDNOG00000015813	RIOK1	100	86.736	Dasypus_novemcinctus
ENSG00000124784	RIOK1	100	89.474	ENSDORG00000008530	Riok1	100	89.474	Dipodomys_ordii
ENSG00000124784	RIOK1	77	53.097	FBgn0036187	RIOK1	82	52.535	Drosophila_melanogaster
ENSG00000124784	RIOK1	100	85.387	ENSETEG00000020273	RIOK1	100	85.563	Echinops_telfairi
ENSG00000124784	RIOK1	99	62.191	ENSEBUG00000013672	riok1	86	67.886	Eptatretus_burgeri
ENSG00000124784	RIOK1	94	89.098	ENSEASG00005012032	RIOK1	94	89.098	Equus_asinus_asinus
ENSG00000124784	RIOK1	100	89.437	ENSECAG00000009007	RIOK1	100	89.437	Equus_caballus
ENSG00000124784	RIOK1	77	75.000	ENSEEUG00000007123	RIOK1	100	75.000	Erinaceus_europaeus
ENSG00000124784	RIOK1	99	65.088	ENSELUG00000017029	riok1	99	63.993	Esox_lucius
ENSG00000124784	RIOK1	100	88.112	ENSFCAG00000027290	RIOK1	100	87.762	Felis_catus
ENSG00000124784	RIOK1	100	77.368	ENSFALG00000013244	RIOK1	100	77.526	Ficedula_albicollis
ENSG00000124784	RIOK1	100	88.752	ENSFDAG00000019139	RIOK1	100	88.752	Fukomys_damarensis
ENSG00000124784	RIOK1	66	76.923	ENSFHEG00000021419	riok1	83	76.923	Fundulus_heteroclitus
ENSG00000124784	RIOK1	73	69.807	ENSGMOG00000018668	riok1	92	72.010	Gadus_morhua
ENSG00000124784	RIOK1	58	76.453	ENSGALG00000012795	RIOK1	100	78.378	Gallus_gallus
ENSG00000124784	RIOK1	91	58.189	ENSGAFG00000004091	riok1	79	61.746	Gambusia_affinis
ENSG00000124784	RIOK1	97	64.791	ENSGACG00000002496	riok1	91	73.375	Gasterosteus_aculeatus
ENSG00000124784	RIOK1	82	77.849	ENSGAGG00000002262	RIOK1	98	79.355	Gopherus_agassizii
ENSG00000124784	RIOK1	97	98.913	ENSGGOG00000011037	RIOK1	100	83.627	Gorilla_gorilla
ENSG00000124784	RIOK1	100	84.710	ENSHGLG00000008699	RIOK1	100	84.886	Heterocephalus_glaber_female
ENSG00000124784	RIOK1	100	85.062	ENSHGLG00100008188	RIOK1	100	85.237	Heterocephalus_glaber_male
ENSG00000124784	RIOK1	88	69.940	ENSHCOG00000013275	riok1	90	70.341	Hippocampus_comes
ENSG00000124784	RIOK1	99	70.035	ENSIPUG00000003290	riok1	100	69.338	Ictalurus_punctatus
ENSG00000124784	RIOK1	100	90.158	ENSSTOG00000009289	RIOK1	100	90.158	Ictidomys_tridecemlineatus
ENSG00000124784	RIOK1	100	86.444	ENSJJAG00000015152	Riok1	100	86.444	Jaculus_jaculus
ENSG00000124784	RIOK1	68	75.064	ENSKMAG00000019378	riok1	99	75.064	Kryptolebias_marmoratus
ENSG00000124784	RIOK1	88	70.659	ENSLBEG00000016650	riok1	86	71.255	Labrus_bergylta
ENSG00000124784	RIOK1	100	66.958	ENSLACG00000000300	RIOK1	100	67.247	Latimeria_chalumnae
ENSG00000124784	RIOK1	99	69.312	ENSLOCG00000011728	riok1	99	71.174	Lepisosteus_oculatus
ENSG00000124784	RIOK1	99	87.367	ENSLAFG00000005504	RIOK1	100	87.367	Loxodonta_africana
ENSG00000124784	RIOK1	100	96.479	ENSMFAG00000029990	RIOK1	100	96.479	Macaca_fascicularis
ENSG00000124784	RIOK1	100	96.303	ENSMMUG00000015577	RIOK1	100	96.303	Macaca_mulatta
ENSG00000124784	RIOK1	100	92.958	ENSMNEG00000034396	RIOK1	99	95.474	Macaca_nemestrina
ENSG00000124784	RIOK1	100	96.831	ENSMLEG00000026327	RIOK1	100	96.831	Mandrillus_leucophaeus
ENSG00000124784	RIOK1	98	65.950	ENSMAMG00000019557	riok1	88	72.323	Mastacembelus_armatus
ENSG00000124784	RIOK1	99	66.489	ENSMZEG00005019482	riok1	99	66.489	Maylandia_zebra
ENSG00000124784	RIOK1	100	74.386	ENSMGAG00000003816	RIOK1	100	75.088	Meleagris_gallopavo
ENSG00000124784	RIOK1	100	83.128	ENSMAUG00000012751	Riok1	100	82.042	Mesocricetus_auratus
ENSG00000124784	RIOK1	100	92.077	ENSMICG00000044301	RIOK1	84	92.077	Microcebus_murinus
ENSG00000124784	RIOK1	100	81.019	ENSMOCG00000017032	Riok1	100	80.282	Microtus_ochrogaster
ENSG00000124784	RIOK1	84	62.672	ENSMMOG00000020598	riok1	87	63.065	Mola_mola
ENSG00000124784	RIOK1	100	78.087	ENSMODG00000009964	RIOK1	100	78.066	Monodelphis_domestica
ENSG00000124784	RIOK1	88	63.928	ENSMALG00000019982	riok1	92	64.082	Monopterus_albus
ENSG00000124784	RIOK1	99	80.783	MGP_CAROLIEiJ_G0018439	Riok1	99	80.749	Mus_caroli
ENSG00000124784	RIOK1	99	79.469	ENSMUSG00000021428	Riok1	99	80.071	Mus_musculus
ENSG00000124784	RIOK1	99	80.570	MGP_PahariEiJ_G0019507	Riok1	99	80.214	Mus_pahari
ENSG00000124784	RIOK1	99	79.893	MGP_SPRETEiJ_G0019319	Riok1	99	80.214	Mus_spretus
ENSG00000124784	RIOK1	100	86.865	ENSMPUG00000000570	RIOK1	100	86.865	Mustela_putorius_furo
ENSG00000124784	RIOK1	100	89.982	ENSMLUG00000015312	RIOK1	100	89.279	Myotis_lucifugus
ENSG00000124784	RIOK1	100	87.852	ENSNGAG00000021734	Riok1	100	88.204	Nannospalax_galili
ENSG00000124784	RIOK1	74	74.704	ENSNBRG00000017489	riok1	83	71.685	Neolamprologus_brichardi
ENSG00000124784	RIOK1	97	95.652	ENSNLEG00000011621	RIOK1	100	88.028	Nomascus_leucogenys
ENSG00000124784	RIOK1	84	52.941	ENSMEUG00000006679	-	84	54.622	Notamacropus_eugenii
ENSG00000124784	RIOK1	65	84.906	ENSOPRG00000009524	RIOK1	100	84.906	Ochotona_princeps
ENSG00000124784	RIOK1	71	77.057	ENSODEG00000005663	RIOK1	100	77.057	Octodon_degus
ENSG00000124784	RIOK1	98	67.979	ENSONIG00000014010	riok1	98	67.616	Oreochromis_niloticus
ENSG00000124784	RIOK1	82	85.991	ENSOANG00000012553	RIOK1	100	85.991	Ornithorhynchus_anatinus
ENSG00000124784	RIOK1	100	88.049	ENSOCUG00000011824	RIOK1	100	88.049	Oryctolagus_cuniculus
ENSG00000124784	RIOK1	98	66.071	ENSORLG00000008221	riok1	86	73.444	Oryzias_latipes
ENSG00000124784	RIOK1	98	64.685	ENSORLG00020013838	riok1	60	72.025	Oryzias_latipes_hni
ENSG00000124784	RIOK1	98	65.714	ENSORLG00015009817	riok1	86	73.597	Oryzias_latipes_hsok
ENSG00000124784	RIOK1	98	65.350	ENSOMEG00000002758	riok1	78	72.557	Oryzias_melastigma
ENSG00000124784	RIOK1	100	79.930	ENSOGAG00000010192	RIOK1	100	79.930	Otolemur_garnettii
ENSG00000124784	RIOK1	100	88.204	ENSOARG00000017747	RIOK1	100	88.204	Ovis_aries
ENSG00000124784	RIOK1	97	97.826	ENSPPAG00000016349	RIOK1	100	95.107	Pan_paniscus
ENSG00000124784	RIOK1	100	88.287	ENSPPRG00000001932	RIOK1	100	87.937	Panthera_pardus
ENSG00000124784	RIOK1	100	88.462	ENSPTIG00000018545	RIOK1	100	88.112	Panthera_tigris_altaica
ENSG00000124784	RIOK1	100	98.768	ENSPTRG00000017700	RIOK1	100	98.768	Pan_troglodytes
ENSG00000124784	RIOK1	100	96.831	ENSPANG00000016522	RIOK1	100	96.831	Papio_anubis
ENSG00000124784	RIOK1	99	67.951	ENSPKIG00000006442	riok1	100	68.206	Paramormyrops_kingsleyae
ENSG00000124784	RIOK1	100	77.289	ENSPSIG00000006488	RIOK1	99	77.504	Pelodiscus_sinensis
ENSG00000124784	RIOK1	70	70.864	ENSPMGG00000017807	riok1	96	68.333	Periophthalmus_magnuspinnatus
ENSG00000124784	RIOK1	100	82.953	ENSPEMG00000017844	Riok1	100	81.866	Peromyscus_maniculatus_bairdii
ENSG00000124784	RIOK1	57	79.077	ENSPMAG00000006351	riok1	77	79.077	Petromyzon_marinus
ENSG00000124784	RIOK1	94	77.196	ENSPCIG00000012653	RIOK1	94	77.298	Phascolarctos_cinereus
ENSG00000124784	RIOK1	98	62.298	ENSPFOG00000011532	riok1	87	69.647	Poecilia_formosa
ENSG00000124784	RIOK1	98	62.118	ENSPLAG00000001341	riok1	87	69.647	Poecilia_latipinna
ENSG00000124784	RIOK1	98	62.298	ENSPMEG00000007710	riok1	89	69.647	Poecilia_mexicana
ENSG00000124784	RIOK1	98	62.118	ENSPREG00000009237	riok1	87	69.811	Poecilia_reticulata
ENSG00000124784	RIOK1	100	98.770	ENSPPYG00000016207	RIOK1	100	98.770	Pongo_abelii
ENSG00000124784	RIOK1	100	73.944	ENSPCAG00000007892	RIOK1	100	74.824	Procavia_capensis
ENSG00000124784	RIOK1	100	91.068	ENSPVAG00000014091	RIOK1	100	89.492	Pteropus_vampyrus
ENSG00000124784	RIOK1	58	70.642	ENSPNYG00000004465	riok1	100	70.642	Pundamilia_nyererei
ENSG00000124784	RIOK1	99	67.770	ENSPNAG00000015435	riok1	99	69.894	Pygocentrus_nattereri
ENSG00000124784	RIOK1	99	81.851	ENSRNOG00000014049	Riok1	100	87.284	Rattus_norvegicus
ENSG00000124784	RIOK1	100	96.831	ENSRBIG00000036685	RIOK1	100	96.831	Rhinopithecus_bieti
ENSG00000124784	RIOK1	100	97.007	ENSRROG00000036611	RIOK1	100	97.007	Rhinopithecus_roxellana
ENSG00000124784	RIOK1	59	41.304	YOR119C	RIO1	96	38.160	Saccharomyces_cerevisiae
ENSG00000124784	RIOK1	100	97.359	ENSSBOG00000012588	RIOK1	100	97.359	Saimiri_boliviensis_boliviensis
ENSG00000124784	RIOK1	85	80.412	ENSSHAG00000003091	RIOK1	93	77.800	Sarcophilus_harrisii
ENSG00000124784	RIOK1	87	72.233	ENSSFOG00015001035	riok1	88	73.737	Scleropages_formosus
ENSG00000124784	RIOK1	58	64.220	ENSSDUG00000007291	riok1	100	64.220	Seriola_dumerili
ENSG00000124784	RIOK1	98	65.771	ENSSLDG00000017657	riok1	99	65.412	Seriola_lalandi_dorsalis
ENSG00000124784	RIOK1	87	68.763	ENSSPUG00000007624	RIOK1	84	69.028	Sphenodon_punctatus
ENSG00000124784	RIOK1	99	68.627	ENSSPAG00000022710	riok1	100	68.271	Stegastes_partitus
ENSG00000124784	RIOK1	100	85.563	ENSSSCG00000001024	RIOK1	100	84.859	Sus_scrofa
ENSG00000124784	RIOK1	100	76.789	ENSTGUG00000002331	RIOK1	100	77.178	Taeniopygia_guttata
ENSG00000124784	RIOK1	52	62.752	ENSTRUG00000001575	-	100	62.752	Takifugu_rubripes
ENSG00000124784	RIOK1	74	62.708	ENSTRUG00000002854	riok1	94	64.175	Takifugu_rubripes
ENSG00000124784	RIOK1	99	59.828	ENSTNIG00000003078	riok1	88	65.524	Tetraodon_nigroviridis
ENSG00000124784	RIOK1	100	85.387	ENSTBEG00000016730	RIOK1	100	84.859	Tupaia_belangeri
ENSG00000124784	RIOK1	73	96.429	ENSTTRG00000017335	RIOK1	87	96.429	Tursiops_truncatus
ENSG00000124784	RIOK1	94	89.306	ENSUAMG00000003721	RIOK1	96	88.743	Ursus_americanus
ENSG00000124784	RIOK1	100	89.807	ENSUMAG00000018461	RIOK1	100	89.104	Ursus_maritimus
ENSG00000124784	RIOK1	70	85.223	ENSVPAG00000010813	-	73	85.223	Vicugna_pacos
ENSG00000124784	RIOK1	100	88.576	ENSVVUG00000005018	RIOK1	100	88.576	Vulpes_vulpes
ENSG00000124784	RIOK1	88	73.948	ENSXETG00000020436	riok1	86	75.000	Xenopus_tropicalis
ENSG00000124784	RIOK1	84	65.126	ENSXCOG00000000245	riok1	100	66.597	Xiphophorus_couchianus
ENSG00000124784	RIOK1	70	74.185	ENSXMAG00000014572	riok1	82	71.765	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004674	protein serine/threonine kinase activity	-	IEA	Function
GO:0005515	protein binding	21081503.25852190.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005829	cytosol	21081503.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006468	protein phosphorylation	-	IEA	Process
GO:0016787	hydrolase activity	-	IEA	Function
GO:0030490	maturation of SSU-rRNA	21873635.	IBA	Process
GO:0030490	maturation of SSU-rRNA	22072790.	IMP	Process
GO:0030688	preribosome, small subunit precursor	21873635.	IBA	Component
GO:0030688	preribosome, small subunit precursor	22072790.	IDA	Component
GO:0034708	methyltransferase complex	21081503.	IMP	Component
GO:0042274	ribosomal small subunit biogenesis	22072790.	IMP	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:2000234	positive regulation of rRNA processing	22072790.	IMP	Process