EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000125207 (Gene tree)
Gene ID: 9271
Gene Symbol: PIWIL1
Alias: PIWI|HIWI|CT80.1
Full Name: piwi like RNA-mediated gene silencing 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 88,374 bases
Position: chr12:130,337,887-130,426,260
Accession: 9007
RBP type: canonical RBP
Summary: This gene encodes a member of the PIWI subfamily of Argonaute proteins, evolutionarily conserved proteins containing both PAZ and Piwi motifs that play important roles in stem cell self-renewal, RNA silencing, and translational regulation in diverse organisms. The encoded protein may play a role as an intrinsic regulator of the self-renewal capacity of germline and hematopoietic stem cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000245255	PAZ	PF02170.22	2e-35	1	1
ENSP00000245255	Piwi	PF02171.17	5.2e-106	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
23241214	Putative molecular mechanism underlying sperm chromatin remodelling is regulated by reproductive hormones.	Clin Epigenetics	2012 Dec 17	Gill-Sharma MK	doi: 10.1186/1868-7083-4-23.
26104391	Novel function of PIWIL1 in neuronal polarization and migration via regulation of microtubule-associated proteins.	Mol Brain	2015 Jun 24	Zhao PP	doi: 10.1186/s13041-015-0131-0.
19597149	MIWI-independent small RNAs (MSY-RNAs) bind to the RNA-binding protein, MSY2, in male germ cells.	Proc Natl Acad Sci U S A	2009 Jul 28	Xu M	doi: 10.1073/pnas.0903944106
24648398	AKAP3 synthesis is mediated by RNA binding proteins and PKA signaling during mouse spermiogenesis.	Biol Reprod	2014 Jun	Xu K	doi: 10.1095/biolreprod.113.116111
24178558	HITS-CLIP (CLIP-Seq) for mouse Piwi proteins.	Methods Mol Biol	2014	Vourekas A	doi: 10.1007/978-1-62703-694-8_7.
28884822	RNA binding protein Musashi-2 regulates PIWIL1 and TBX1 in mouse spermatogenesis.	J Cell Physiol	2018 Apr	Sutherland JM	doi: 10.1002/jcp.26168
29701755	Domain-functional analyses of PIWIL1 and PABPC1 indicate their synergistic roles in protein translation via 3'-UTRs of meiotic mRNAs.	Biol Reprod	2018 Oct 1	Wu Y	doi: 10.1093/biolre/ioy100.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000539995	PIWIL1-204	545	-	ENSP00000439096	150 (aa)	-	F5H3U6
ENST00000539400	PIWIL1-203	467	-	ENSP00000440677	122 (aa)	-	F5GYG0
ENST00000542723	PIWIL1-207	879	-	ENSP00000438582	172 (aa)	-	F5H2F7
ENST00000546060	PIWIL1-208	571	-	ENSP00000442086	165 (aa)	-	F5H889
ENST00000540672	PIWIL1-205	1051	-	-	- (aa)	-	-
ENST00000245255	PIWIL1-201	3897	XM_011539002	ENSP00000245255	861 (aa)	XP_011537304	Q96J94
ENST00000535956	PIWIL1-202	566	-	ENSP00000444353	117 (aa)	-	F5GZL9
ENST00000541480	PIWIL1-206	545	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000125207's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000125207	Platelet Function Tests	9.7440759E-007	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000125207	rs28416520	12	130339112	?	Age at menopause	30595370			EFO_0004704

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000125207's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000125207	PIWIL1	97	50.466	ENSG00000184571	PIWIL3	100	52.282
ENSG00000125207	PIWIL1	100	48.958	ENSG00000134627	PIWIL4	89	61.326
ENSG00000125207	PIWIL1	88	42.651	ENSG00000197181	PIWIL2	78	42.651

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000125207	PIWIL1	99	39.821	ENSAPOG00000020227	piwil2	83	42.147	Acanthochromis_polyacanthus
ENSG00000125207	PIWIL1	94	63.145	ENSAPOG00000004324	piwil1	99	63.171	Acanthochromis_polyacanthus
ENSG00000125207	PIWIL1	78	53.166	ENSAMEG00000008922	-	98	53.166	Ailuropoda_melanoleuca
ENSG00000125207	PIWIL1	88	43.455	ENSAMEG00000003171	PIWIL2	78	43.455	Ailuropoda_melanoleuca
ENSG00000125207	PIWIL1	100	49.483	ENSAMEG00000007580	PIWIL4	99	49.354	Ailuropoda_melanoleuca
ENSG00000125207	PIWIL1	98	95.626	ENSAMEG00000006533	PIWIL1	98	95.626	Ailuropoda_melanoleuca
ENSG00000125207	PIWIL1	89	41.797	ENSACIG00000018881	piwil2	95	49.462	Amphilophus_citrinellus
ENSG00000125207	PIWIL1	95	63.126	ENSAOCG00000012967	piwil1	98	62.919	Amphiprion_ocellaris
ENSG00000125207	PIWIL1	88	42.353	ENSAOCG00000009899	piwil2	99	42.353	Amphiprion_ocellaris
ENSG00000125207	PIWIL1	89	41.743	ENSAPEG00000005521	piwil2	95	48.029	Amphiprion_percula
ENSG00000125207	PIWIL1	93	62.610	ENSAPEG00000009239	piwil1	99	61.185	Amphiprion_percula
ENSG00000125207	PIWIL1	53	72.727	ENSATEG00000021001	-	79	72.727	Anabas_testudineus
ENSG00000125207	PIWIL1	90	41.952	ENSATEG00000016118	piwil2	74	41.952	Anabas_testudineus
ENSG00000125207	PIWIL1	93	65.621	ENSATEG00000019796	piwil1	99	63.986	Anabas_testudineus
ENSG00000125207	PIWIL1	98	77.193	ENSAPLG00000012285	PIWIL1	98	77.427	Anas_platyrhynchos
ENSG00000125207	PIWIL1	85	37.216	ENSAPLG00000014006	PIWIL2	100	37.216	Anas_platyrhynchos
ENSG00000125207	PIWIL1	95	76.829	ENSACAG00000015614	-	96	76.196	Anolis_carolinensis
ENSG00000125207	PIWIL1	93	77.666	ENSACAG00000010879	-	99	76.338	Anolis_carolinensis
ENSG00000125207	PIWIL1	88	41.678	ENSACAG00000010657	PIWIL2	86	41.678	Anolis_carolinensis
ENSG00000125207	PIWIL1	97	48.655	ENSANAG00000031385	PIWIL3	96	48.655	Aotus_nancymaae
ENSG00000125207	PIWIL1	88	42.651	ENSANAG00000027198	PIWIL2	78	42.651	Aotus_nancymaae
ENSG00000125207	PIWIL1	100	96.516	ENSANAG00000024013	PIWIL1	100	96.516	Aotus_nancymaae
ENSG00000125207	PIWIL1	90	50.963	ENSANAG00000031191	PIWIL4	97	62.431	Aotus_nancymaae
ENSG00000125207	PIWIL1	95	63.570	ENSACLG00000014540	piwil1	98	62.766	Astatotilapia_calliptera
ENSG00000125207	PIWIL1	90	41.849	ENSACLG00000020551	piwil2	73	41.849	Astatotilapia_calliptera
ENSG00000125207	PIWIL1	90	60.797	ENSACLG00000005760	-	90	60.797	Astatotilapia_calliptera
ENSG00000125207	PIWIL1	88	43.644	ENSAMXG00000001746	piwil2	69	43.644	Astyanax_mexicanus
ENSG00000125207	PIWIL1	98	65.284	ENSAMXG00000015370	piwil1	99	65.207	Astyanax_mexicanus
ENSG00000125207	PIWIL1	99	47.982	ENSBTAG00000014910	PIWIL4	92	49.623	Bos_taurus
ENSG00000125207	PIWIL1	95	40.674	ENSBTAG00000015835	PIWIL2	85	40.674	Bos_taurus
ENSG00000125207	PIWIL1	100	50.617	ENSBTAG00000015526	PIWIL3	94	51.786	Bos_taurus
ENSG00000125207	PIWIL1	98	96.099	ENSBTAG00000006468	PIWIL1	98	96.099	Bos_taurus
ENSG00000125207	PIWIL1	88	34.925	WBGene00004178	prg-1	99	33.725	Caenorhabditis_elegans
ENSG00000125207	PIWIL1	91	51.519	ENSCJAG00000004075	PIWIL4	97	51.576	Callithrix_jacchus
ENSG00000125207	PIWIL1	88	42.651	ENSCJAG00000020263	PIWIL2	78	42.651	Callithrix_jacchus
ENSG00000125207	PIWIL1	100	96.283	ENSCJAG00000010879	PIWIL1	100	96.283	Callithrix_jacchus
ENSG00000125207	PIWIL1	98	95.863	ENSCAFG00000006773	PIWIL1	98	95.863	Canis_familiaris
ENSG00000125207	PIWIL1	96	49.403	ENSCAFG00000004147	PIWIL4	97	49.403	Canis_familiaris
ENSG00000125207	PIWIL1	88	43.045	ENSCAFG00000009444	PIWIL2	78	43.045	Canis_familiaris
ENSG00000125207	PIWIL1	97	56.080	ENSCAFG00000010566	PIWIL3	97	56.287	Canis_familiaris
ENSG00000125207	PIWIL1	92	51.131	ENSCAFG00020016521	PIWIL4	87	62.983	Canis_lupus_dingo
ENSG00000125207	PIWIL1	88	43.045	ENSCAFG00020012983	PIWIL2	78	43.045	Canis_lupus_dingo
ENSG00000125207	PIWIL1	98	94.917	ENSCAFG00020011618	PIWIL1	98	94.917	Canis_lupus_dingo
ENSG00000125207	PIWIL1	93	57.750	ENSCAFG00020020864	PIWIL3	97	57.750	Canis_lupus_dingo
ENSG00000125207	PIWIL1	100	50.785	ENSCHIG00000024941	-	84	52.138	Capra_hircus
ENSG00000125207	PIWIL1	88	42.333	ENSCHIG00000022958	PIWIL2	78	42.333	Capra_hircus
ENSG00000125207	PIWIL1	100	47.977	ENSCHIG00000007777	PIWIL4	99	49.029	Capra_hircus
ENSG00000125207	PIWIL1	98	96.099	ENSCHIG00000008831	PIWIL1	98	96.099	Capra_hircus
ENSG00000125207	PIWIL1	100	39.977	ENSTSYG00000009617	PIWIL2	80	42.377	Carlito_syrichta
ENSG00000125207	PIWIL1	90	50.000	ENSTSYG00000005577	PIWIL4	99	50.000	Carlito_syrichta
ENSG00000125207	PIWIL1	98	93.262	ENSTSYG00000006226	PIWIL1	98	93.262	Carlito_syrichta
ENSG00000125207	PIWIL1	97	94.012	ENSCAPG00000006492	PIWIL1	100	94.012	Cavia_aperea
ENSG00000125207	PIWIL1	88	43.250	ENSCPOG00000001108	PIWIL2	78	43.250	Cavia_porcellus
ENSG00000125207	PIWIL1	100	39.665	ENSCPOG00000000070	PIWIL4	91	47.813	Cavia_porcellus
ENSG00000125207	PIWIL1	97	95.210	ENSCPOG00000004830	PIWIL1	100	95.210	Cavia_porcellus
ENSG00000125207	PIWIL1	93	45.500	ENSCPOG00000026791	-	100	45.500	Cavia_porcellus
ENSG00000125207	PIWIL1	92	51.375	ENSCCAG00000017581	PIWIL4	96	61.667	Cebus_capucinus
ENSG00000125207	PIWIL1	97	49.121	ENSCCAG00000025474	PIWIL3	96	49.121	Cebus_capucinus
ENSG00000125207	PIWIL1	88	42.988	ENSCCAG00000033068	PIWIL2	78	42.988	Cebus_capucinus
ENSG00000125207	PIWIL1	100	96.864	ENSCCAG00000036270	PIWIL1	100	96.864	Cebus_capucinus
ENSG00000125207	PIWIL1	88	42.782	ENSCATG00000039784	PIWIL2	78	42.782	Cercocebus_atys
ENSG00000125207	PIWIL1	100	48.956	ENSCATG00000030289	PIWIL4	98	49.289	Cercocebus_atys
ENSG00000125207	PIWIL1	97	50.709	ENSCATG00000044030	PIWIL3	94	50.709	Cercocebus_atys
ENSG00000125207	PIWIL1	100	98.722	ENSCATG00000033903	PIWIL1	100	98.722	Cercocebus_atys
ENSG00000125207	PIWIL1	53	50.327	ENSCLAG00000000369	-	100	50.327	Chinchilla_lanigera
ENSG00000125207	PIWIL1	90	42.821	ENSCLAG00000013810	PIWIL2	86	41.816	Chinchilla_lanigera
ENSG00000125207	PIWIL1	97	94.724	ENSCLAG00000008176	PIWIL1	99	94.724	Chinchilla_lanigera
ENSG00000125207	PIWIL1	100	98.606	ENSCSAG00000001922	PIWIL1	100	98.606	Chlorocebus_sabaeus
ENSG00000125207	PIWIL1	100	48.621	ENSCSAG00000003360	PIWIL4	98	48.934	Chlorocebus_sabaeus
ENSG00000125207	PIWIL1	97	50.591	ENSCSAG00000010421	PIWIL3	97	50.591	Chlorocebus_sabaeus
ENSG00000125207	PIWIL1	88	42.782	ENSCSAG00000016512	PIWIL2	78	42.782	Chlorocebus_sabaeus
ENSG00000125207	PIWIL1	74	44.156	ENSCHOG00000003987	PIWIL2	75	44.156	Choloepus_hoffmanni
ENSG00000125207	PIWIL1	98	93.381	ENSCHOG00000012232	PIWIL1	98	93.381	Choloepus_hoffmanni
ENSG00000125207	PIWIL1	66	53.617	ENSCHOG00000008023	PIWIL4	67	53.617	Choloepus_hoffmanni
ENSG00000125207	PIWIL1	88	53.034	ENSCPBG00000024031	PIWIL4	98	53.034	Chrysemys_picta_bellii
ENSG00000125207	PIWIL1	96	86.369	ENSCPBG00000024818	PIWIL1	100	86.369	Chrysemys_picta_bellii
ENSG00000125207	PIWIL1	95	40.413	ENSCPBG00000001412	PIWIL2	99	40.413	Chrysemys_picta_bellii
ENSG00000125207	PIWIL1	85	44.667	ENSCING00000020739	-	88	44.667	Ciona_intestinalis
ENSG00000125207	PIWIL1	91	49.118	ENSCSAVG00000003205	-	100	49.118	Ciona_savignyi
ENSG00000125207	PIWIL1	88	44.015	ENSCSAVG00000000100	-	97	44.015	Ciona_savignyi
ENSG00000125207	PIWIL1	82	43.820	ENSCANG00000039176	PIWIL3	92	43.820	Colobus_angolensis_palliatus
ENSG00000125207	PIWIL1	88	42.651	ENSCANG00000003031	PIWIL2	78	42.651	Colobus_angolensis_palliatus
ENSG00000125207	PIWIL1	100	98.722	ENSCANG00000038755	PIWIL1	100	98.722	Colobus_angolensis_palliatus
ENSG00000125207	PIWIL1	100	48.786	ENSCANG00000041660	PIWIL4	98	49.052	Colobus_angolensis_palliatus
ENSG00000125207	PIWIL1	90	89.589	ENSCGRG00001016679	-	97	89.589	Cricetulus_griseus_chok1gshd
ENSG00000125207	PIWIL1	100	49.072	ENSCGRG00001017873	Piwil4	94	51.523	Cricetulus_griseus_chok1gshd
ENSG00000125207	PIWIL1	88	43.119	ENSCGRG00001013004	Piwil2	78	43.119	Cricetulus_griseus_chok1gshd
ENSG00000125207	PIWIL1	98	95.041	ENSCGRG00001023409	-	98	95.041	Cricetulus_griseus_chok1gshd
ENSG00000125207	PIWIL1	91	51.396	ENSCGRG00000016077	Piwil4	100	52.174	Cricetulus_griseus_crigri
ENSG00000125207	PIWIL1	88	43.119	ENSCGRG00000005237	Piwil2	78	43.119	Cricetulus_griseus_crigri
ENSG00000125207	PIWIL1	98	95.041	ENSCGRG00000004482	-	98	95.041	Cricetulus_griseus_crigri
ENSG00000125207	PIWIL1	60	92.593	ENSCGRG00000000724	-	100	92.593	Cricetulus_griseus_crigri
ENSG00000125207	PIWIL1	88	40.707	ENSCSEG00000011256	piwil2	72	40.707	Cynoglossus_semilaevis
ENSG00000125207	PIWIL1	100	59.281	ENSCSEG00000015998	piwil1	97	62.578	Cynoglossus_semilaevis
ENSG00000125207	PIWIL1	89	42.839	ENSCVAG00000022932	piwil2	75	42.839	Cyprinodon_variegatus
ENSG00000125207	PIWIL1	89	42.876	ENSDARG00000062601	piwil2	73	42.876	Danio_rerio
ENSG00000125207	PIWIL1	97	64.303	ENSDARG00000041699	piwil1	99	64.042	Danio_rerio
ENSG00000125207	PIWIL1	100	90.116	ENSDNOG00000015261	PIWIL1	100	88.516	Dasypus_novemcinctus
ENSG00000125207	PIWIL1	88	42.595	ENSDNOG00000001468	PIWIL2	78	42.595	Dasypus_novemcinctus
ENSG00000125207	PIWIL1	90	50.895	ENSDNOG00000016814	PIWIL4	100	50.895	Dasypus_novemcinctus
ENSG00000125207	PIWIL1	88	37.971	ENSDORG00000011177	Piwil2	78	37.971	Dipodomys_ordii
ENSG00000125207	PIWIL1	98	95.745	ENSDORG00000010479	Piwil1	98	95.745	Dipodomys_ordii
ENSG00000125207	PIWIL1	88	41.425	FBgn0250816	AGO3	86	41.425	Drosophila_melanogaster
ENSG00000125207	PIWIL1	88	39.147	FBgn0000146	aub	96	39.147	Drosophila_melanogaster
ENSG00000125207	PIWIL1	88	38.003	FBgn0004872	piwi	90	38.003	Drosophila_melanogaster
ENSG00000125207	PIWIL1	88	35.256	ENSETEG00000004818	PIWIL2	78	35.256	Echinops_telfairi
ENSG00000125207	PIWIL1	98	95.035	ENSETEG00000001720	PIWIL1	98	95.035	Echinops_telfairi
ENSG00000125207	PIWIL1	92	56.462	ENSEBUG00000003745	piwil1	98	56.462	Eptatretus_burgeri
ENSG00000125207	PIWIL1	88	42.520	ENSEASG00005018819	PIWIL2	78	42.520	Equus_asinus_asinus
ENSG00000125207	PIWIL1	92	57.987	ENSEASG00005007918	PIWIL3	98	57.987	Equus_asinus_asinus
ENSG00000125207	PIWIL1	98	95.277	ENSEASG00005013191	PIWIL1	98	95.277	Equus_asinus_asinus
ENSG00000125207	PIWIL1	97	57.467	ENSECAG00000018484	PIWIL3	95	57.449	Equus_caballus
ENSG00000125207	PIWIL1	98	95.745	ENSECAG00000016506	PIWIL1	82	95.745	Equus_caballus
ENSG00000125207	PIWIL1	97	50.060	ENSECAG00000024385	PIWIL4	98	50.060	Equus_caballus
ENSG00000125207	PIWIL1	88	42.520	ENSECAG00000025128	PIWIL2	78	42.520	Equus_caballus
ENSG00000125207	PIWIL1	77	40.923	ENSEEUG00000005861	PIWIL2	76	40.923	Erinaceus_europaeus
ENSG00000125207	PIWIL1	52	59.459	ENSEEUG00000004977	-	54	59.459	Erinaceus_europaeus
ENSG00000125207	PIWIL1	100	89.535	ENSEEUG00000003872	PIWIL1	91	96.970	Erinaceus_europaeus
ENSG00000125207	PIWIL1	88	43.644	ENSELUG00000007978	piwil2	71	43.644	Esox_lucius
ENSG00000125207	PIWIL1	97	65.077	ENSELUG00000019888	piwil1	98	65.077	Esox_lucius
ENSG00000125207	PIWIL1	98	95.396	ENSFCAG00000014305	PIWIL1	98	95.390	Felis_catus
ENSG00000125207	PIWIL1	94	49.814	ENSFCAG00000010914	PIWIL4	95	50.362	Felis_catus
ENSG00000125207	PIWIL1	88	42.670	ENSFCAG00000012981	PIWIL2	78	42.670	Felis_catus
ENSG00000125207	PIWIL1	93	52.292	ENSFCAG00000006400	PIWIL3	96	50.760	Felis_catus
ENSG00000125207	PIWIL1	89	75.491	ENSFALG00000009492	PIWIL1	99	75.491	Ficedula_albicollis
ENSG00000125207	PIWIL1	88	43.979	ENSFDAG00000007369	PIWIL2	78	43.979	Fukomys_damarensis
ENSG00000125207	PIWIL1	99	91.365	ENSFDAG00000011345	PIWIL1	100	94.321	Fukomys_damarensis
ENSG00000125207	PIWIL1	79	51.906	ENSFDAG00000020222	-	99	51.906	Fukomys_damarensis
ENSG00000125207	PIWIL1	100	48.958	ENSFDAG00000017791	PIWIL4	94	50.062	Fukomys_damarensis
ENSG00000125207	PIWIL1	95	62.439	ENSFHEG00000001418	piwil1	97	62.364	Fundulus_heteroclitus
ENSG00000125207	PIWIL1	89	41.460	ENSFHEG00000022000	piwil2	73	41.460	Fundulus_heteroclitus
ENSG00000125207	PIWIL1	67	45.172	ENSGMOG00000007585	piwil2	99	45.172	Gadus_morhua
ENSG00000125207	PIWIL1	93	64.366	ENSGMOG00000006726	piwil1	93	64.366	Gadus_morhua
ENSG00000125207	PIWIL1	99	76.851	ENSGALG00000002645	PIWIL1	96	77.566	Gallus_gallus
ENSG00000125207	PIWIL1	88	40.969	ENSGAFG00000006228	piwil2	72	40.969	Gambusia_affinis
ENSG00000125207	PIWIL1	67	44.234	ENSGACG00000012851	piwil2	99	44.234	Gasterosteus_aculeatus
ENSG00000125207	PIWIL1	95	63.814	ENSGACG00000012220	piwil1	98	63.365	Gasterosteus_aculeatus
ENSG00000125207	PIWIL1	88	42.202	ENSGAGG00000012123	PIWIL2	78	42.202	Gopherus_agassizii
ENSG00000125207	PIWIL1	94	52.754	ENSGAGG00000009717	PIWIL4	99	52.754	Gopherus_agassizii
ENSG00000125207	PIWIL1	98	85.562	ENSGAGG00000003090	PIWIL1	97	85.799	Gopherus_agassizii
ENSG00000125207	PIWIL1	97	50.583	ENSGGOG00000015492	PIWIL3	100	52.412	Gorilla_gorilla
ENSG00000125207	PIWIL1	100	100.000	ENSGGOG00000015722	PIWIL1	100	99.768	Gorilla_gorilla
ENSG00000125207	PIWIL1	67	44.178	ENSGGOG00000008783	-	93	44.178	Gorilla_gorilla
ENSG00000125207	PIWIL1	100	49.135	ENSGGOG00000016276	PIWIL4	98	49.408	Gorilla_gorilla
ENSG00000125207	PIWIL1	90	40.693	ENSHBUG00000011225	piwil2	95	46.237	Haplochromis_burtoni
ENSG00000125207	PIWIL1	90	62.773	ENSHBUG00000000983	piwil1	96	61.958	Haplochromis_burtoni
ENSG00000125207	PIWIL1	98	91.972	ENSHGLG00000011158	PIWIL1	98	91.972	Heterocephalus_glaber_female
ENSG00000125207	PIWIL1	95	40.958	ENSHGLG00000015853	PIWIL2	86	40.958	Heterocephalus_glaber_female
ENSG00000125207	PIWIL1	53	50.980	ENSHGLG00000007416	-	100	50.980	Heterocephalus_glaber_female
ENSG00000125207	PIWIL1	98	91.972	ENSHGLG00100019433	PIWIL1	98	91.972	Heterocephalus_glaber_male
ENSG00000125207	PIWIL1	95	40.958	ENSHGLG00100019213	PIWIL2	86	40.958	Heterocephalus_glaber_male
ENSG00000125207	PIWIL1	53	50.980	ENSHGLG00100010413	-	100	50.980	Heterocephalus_glaber_male
ENSG00000125207	PIWIL1	97	60.979	ENSHCOG00000000796	piwil1	100	62.375	Hippocampus_comes
ENSG00000125207	PIWIL1	89	42.153	ENSHCOG00000002903	piwil2	95	46.953	Hippocampus_comes
ENSG00000125207	PIWIL1	88	42.520	ENSIPUG00000018436	piwil2	93	40.838	Ictalurus_punctatus
ENSG00000125207	PIWIL1	93	65.119	ENSIPUG00000016443	piwil1	93	65.414	Ictalurus_punctatus
ENSG00000125207	PIWIL1	98	95.863	ENSSTOG00000005154	PIWIL1	98	95.863	Ictidomys_tridecemlineatus
ENSG00000125207	PIWIL1	88	42.857	ENSSTOG00000016520	PIWIL2	79	42.857	Ictidomys_tridecemlineatus
ENSG00000125207	PIWIL1	53	51.732	ENSSTOG00000006932	-	100	51.732	Ictidomys_tridecemlineatus
ENSG00000125207	PIWIL1	98	95.277	ENSJJAG00000022411	Piwil1	98	95.277	Jaculus_jaculus
ENSG00000125207	PIWIL1	85	39.242	ENSJJAG00000005065	Piwil2	77	39.242	Jaculus_jaculus
ENSG00000125207	PIWIL1	88	42.147	ENSKMAG00000009865	piwil2	95	48.746	Kryptolebias_marmoratus
ENSG00000125207	PIWIL1	93	63.990	ENSKMAG00000020353	piwil1	94	63.990	Kryptolebias_marmoratus
ENSG00000125207	PIWIL1	97	40.334	ENSLBEG00000008001	piwil2	94	41.419	Labrus_bergylta
ENSG00000125207	PIWIL1	93	63.250	ENSLBEG00000024216	piwil1	99	62.228	Labrus_bergylta
ENSG00000125207	PIWIL1	97	75.833	ENSLACG00000018850	PIWIL1	96	76.421	Latimeria_chalumnae
ENSG00000125207	PIWIL1	66	46.678	ENSLACG00000001172	PIWIL4	100	47.029	Latimeria_chalumnae
ENSG00000125207	PIWIL1	100	40.852	ENSLACG00000001069	PIWIL2	79	43.832	Latimeria_chalumnae
ENSG00000125207	PIWIL1	93	66.499	ENSLOCG00000006283	piwil1	92	66.499	Lepisosteus_oculatus
ENSG00000125207	PIWIL1	88	43.438	ENSLOCG00000015407	piwil2	71	43.438	Lepisosteus_oculatus
ENSG00000125207	PIWIL1	88	42.857	ENSLAFG00000016420	PIWIL2	78	42.857	Loxodonta_africana
ENSG00000125207	PIWIL1	100	50.230	ENSLAFG00000008418	PIWIL4	98	50.059	Loxodonta_africana
ENSG00000125207	PIWIL1	98	95.508	ENSLAFG00000013812	PIWIL1	98	95.508	Loxodonta_africana
ENSG00000125207	PIWIL1	89	52.157	ENSMFAG00000003570	PIWIL3	99	52.157	Macaca_fascicularis
ENSG00000125207	PIWIL1	100	48.840	ENSMFAG00000042631	PIWIL4	98	49.289	Macaca_fascicularis
ENSG00000125207	PIWIL1	100	98.722	ENSMFAG00000042638	PIWIL1	100	98.722	Macaca_fascicularis
ENSG00000125207	PIWIL1	88	42.651	ENSMFAG00000038537	PIWIL2	78	42.651	Macaca_fascicularis
ENSG00000125207	PIWIL1	97	50.177	ENSMMUG00000020325	PIWIL3	96	50.588	Macaca_mulatta
ENSG00000125207	PIWIL1	100	96.512	ENSMMUG00000005629	PIWIL1	100	94.657	Macaca_mulatta
ENSG00000125207	PIWIL1	88	42.651	ENSMMUG00000014438	PIWIL2	78	42.651	Macaca_mulatta
ENSG00000125207	PIWIL1	100	48.840	ENSMMUG00000008965	PIWIL4	98	49.408	Macaca_mulatta
ENSG00000125207	PIWIL1	97	49.234	ENSMNEG00000040579	PIWIL3	96	49.765	Macaca_nemestrina
ENSG00000125207	PIWIL1	88	40.629	ENSMNEG00000029268	PIWIL2	78	40.629	Macaca_nemestrina
ENSG00000125207	PIWIL1	100	48.956	ENSMNEG00000037456	PIWIL4	98	49.408	Macaca_nemestrina
ENSG00000125207	PIWIL1	100	98.722	ENSMNEG00000044909	PIWIL1	100	98.722	Macaca_nemestrina
ENSG00000125207	PIWIL1	100	98.722	ENSMLEG00000035718	PIWIL1	100	98.722	Mandrillus_leucophaeus
ENSG00000125207	PIWIL1	100	48.786	ENSMLEG00000029752	PIWIL4	98	49.052	Mandrillus_leucophaeus
ENSG00000125207	PIWIL1	97	50.175	ENSMLEG00000038128	PIWIL3	99	52.418	Mandrillus_leucophaeus
ENSG00000125207	PIWIL1	88	40.289	ENSMLEG00000041768	PIWIL2	77	40.289	Mandrillus_leucophaeus
ENSG00000125207	PIWIL1	93	41.371	ENSMAMG00000000487	piwil2	100	41.922	Mastacembelus_armatus
ENSG00000125207	PIWIL1	93	63.363	ENSMAMG00000005264	piwil1	96	63.363	Mastacembelus_armatus
ENSG00000125207	PIWIL1	95	62.714	ENSMZEG00005008579	piwil1	98	61.939	Maylandia_zebra
ENSG00000125207	PIWIL1	90	41.849	ENSMZEG00005018757	piwil2	73	41.849	Maylandia_zebra
ENSG00000125207	PIWIL1	99	76.761	ENSMGAG00000002382	PIWIL1	97	77.032	Meleagris_gallopavo
ENSG00000125207	PIWIL1	68	41.327	ENSMAUG00000003138	Piwil2	73	41.327	Mesocricetus_auratus
ENSG00000125207	PIWIL1	100	49.197	ENSMAUG00000011382	Piwil4	100	52.700	Mesocricetus_auratus
ENSG00000125207	PIWIL1	98	94.687	ENSMAUG00000016892	Piwil1	98	94.687	Mesocricetus_auratus
ENSG00000125207	PIWIL1	98	95.868	ENSMICG00000004852	PIWIL1	98	95.868	Microcebus_murinus
ENSG00000125207	PIWIL1	96	50.424	ENSMICG00000029782	PIWIL3	97	49.941	Microcebus_murinus
ENSG00000125207	PIWIL1	100	48.686	ENSMICG00000006375	PIWIL4	93	51.314	Microcebus_murinus
ENSG00000125207	PIWIL1	88	43.455	ENSMICG00000001062	PIWIL2	78	43.455	Microcebus_murinus
ENSG00000125207	PIWIL1	98	94.687	ENSMOCG00000015999	Piwil1	98	94.687	Microtus_ochrogaster
ENSG00000125207	PIWIL1	100	50.000	ENSMOCG00000020261	Piwil4	98	49.882	Microtus_ochrogaster
ENSG00000125207	PIWIL1	88	43.119	ENSMOCG00000003446	Piwil2	78	43.119	Microtus_ochrogaster
ENSG00000125207	PIWIL1	94	40.781	ENSMMOG00000014703	piwil2	99	40.781	Mola_mola
ENSG00000125207	PIWIL1	91	63.151	ENSMMOG00000001839	piwil1	100	63.151	Mola_mola
ENSG00000125207	PIWIL1	98	92.435	ENSMODG00000015619	PIWIL1	98	92.435	Monodelphis_domestica
ENSG00000125207	PIWIL1	100	50.000	ENSMODG00000000217	PIWIL4	97	50.120	Monodelphis_domestica
ENSG00000125207	PIWIL1	88	42.105	ENSMODG00000009482	PIWIL2	100	42.105	Monodelphis_domestica
ENSG00000125207	PIWIL1	89	42.003	ENSMALG00000017274	piwil2	71	42.003	Monopterus_albus
ENSG00000125207	PIWIL1	98	59.976	ENSMALG00000019391	piwil1	98	59.976	Monopterus_albus
ENSG00000125207	PIWIL1	98	94.687	MGP_CAROLIEiJ_G0027775	Piwil1	98	94.687	Mus_caroli
ENSG00000125207	PIWIL1	88	42.857	MGP_CAROLIEiJ_G0019480	Piwil2	78	42.857	Mus_caroli
ENSG00000125207	PIWIL1	100	49.192	MGP_CAROLIEiJ_G0031784	Piwil4	100	51.844	Mus_caroli
ENSG00000125207	PIWIL1	100	49.074	ENSMUSG00000036912	Piwil4	96	50.673	Mus_musculus
ENSG00000125207	PIWIL1	88	42.857	ENSMUSG00000033644	Piwil2	78	42.857	Mus_musculus
ENSG00000125207	PIWIL1	98	94.805	ENSMUSG00000029423	Piwil1	98	94.805	Mus_musculus
ENSG00000125207	PIWIL1	88	42.857	MGP_PahariEiJ_G0030497	Piwil2	78	42.857	Mus_pahari
ENSG00000125207	PIWIL1	100	48.843	MGP_PahariEiJ_G0014660	Piwil4	100	50.759	Mus_pahari
ENSG00000125207	PIWIL1	98	94.569	MGP_PahariEiJ_G0024355	Piwil1	98	94.569	Mus_pahari
ENSG00000125207	PIWIL1	88	42.857	MGP_SPRETEiJ_G0020372	Piwil2	78	42.857	Mus_spretus
ENSG00000125207	PIWIL1	98	94.805	MGP_SPRETEiJ_G0028774	Piwil1	98	94.805	Mus_spretus
ENSG00000125207	PIWIL1	100	48.727	MGP_SPRETEiJ_G0032904	Piwil4	100	51.410	Mus_spretus
ENSG00000125207	PIWIL1	92	49.751	ENSMPUG00000012256	PIWIL4	99	49.751	Mustela_putorius_furo
ENSG00000125207	PIWIL1	97	51.300	ENSMPUG00000013703	PIWIL3	97	51.415	Mustela_putorius_furo
ENSG00000125207	PIWIL1	88	42.988	ENSMPUG00000003645	PIWIL2	78	42.988	Mustela_putorius_furo
ENSG00000125207	PIWIL1	98	95.863	ENSMPUG00000004243	PIWIL1	98	95.863	Mustela_putorius_furo
ENSG00000125207	PIWIL1	88	43.250	ENSMLUG00000002115	PIWIL2	84	41.341	Myotis_lucifugus
ENSG00000125207	PIWIL1	100	48.495	ENSMLUG00000002018	PIWIL4	98	48.514	Myotis_lucifugus
ENSG00000125207	PIWIL1	88	42.988	ENSNGAG00000015408	Piwil2	78	42.988	Nannospalax_galili
ENSG00000125207	PIWIL1	98	94.097	ENSNGAG00000017950	Piwil1	98	94.097	Nannospalax_galili
ENSG00000125207	PIWIL1	100	48.555	ENSNGAG00000022297	Piwil4	100	48.555	Nannospalax_galili
ENSG00000125207	PIWIL1	93	64.366	ENSNBRG00000008895	piwil1	95	64.366	Neolamprologus_brichardi
ENSG00000125207	PIWIL1	88	40.682	ENSNLEG00000015534	PIWIL2	79	41.339	Nomascus_leucogenys
ENSG00000125207	PIWIL1	100	97.561	ENSNLEG00000008225	PIWIL1	100	97.561	Nomascus_leucogenys
ENSG00000125207	PIWIL1	100	46.636	ENSNLEG00000007119	PIWIL4	98	46.849	Nomascus_leucogenys
ENSG00000125207	PIWIL1	97	50.467	ENSNLEG00000007677	PIWIL3	97	50.875	Nomascus_leucogenys
ENSG00000125207	PIWIL1	77	48.260	ENSMEUG00000005110	PIWIL4	84	48.260	Notamacropus_eugenii
ENSG00000125207	PIWIL1	93	70.765	ENSMEUG00000010800	PIWIL1	93	70.765	Notamacropus_eugenii
ENSG00000125207	PIWIL1	62	37.719	ENSMEUG00000016543	-	55	37.719	Notamacropus_eugenii
ENSG00000125207	PIWIL1	63	97.222	ENSOPRG00000003656	-	88	90.244	Ochotona_princeps
ENSG00000125207	PIWIL1	100	32.121	ENSOPRG00000009976	-	51	67.717	Ochotona_princeps
ENSG00000125207	PIWIL1	64	40.614	ENSOPRG00000013167	PIWIL2	69	40.614	Ochotona_princeps
ENSG00000125207	PIWIL1	91	47.722	ENSOPRG00000004245	-	93	47.722	Ochotona_princeps
ENSG00000125207	PIWIL1	100	88.372	ENSODEG00000010629	PIWIL1	98	88.771	Octodon_degus
ENSG00000125207	PIWIL1	88	43.586	ENSODEG00000009752	PIWIL2	78	43.586	Octodon_degus
ENSG00000125207	PIWIL1	95	48.775	ENSODEG00000013015	PIWIL4	96	48.775	Octodon_degus
ENSG00000125207	PIWIL1	89	42.173	ENSONIG00000011121	piwil2	72	42.173	Oreochromis_niloticus
ENSG00000125207	PIWIL1	95	63.447	ENSONIG00000010951	piwil1	98	62.648	Oreochromis_niloticus
ENSG00000125207	PIWIL1	94	88.490	ENSOANG00000011950	-	100	88.490	Ornithorhynchus_anatinus
ENSG00000125207	PIWIL1	88	43.307	ENSOANG00000010778	PIWIL2	78	43.307	Ornithorhynchus_anatinus
ENSG00000125207	PIWIL1	98	95.272	ENSOCUG00000027444	PIWIL1	98	95.272	Oryctolagus_cuniculus
ENSG00000125207	PIWIL1	88	42.595	ENSOCUG00000006261	PIWIL2	78	42.595	Oryctolagus_cuniculus
ENSG00000125207	PIWIL1	100	48.851	ENSOCUG00000002860	PIWIL4	97	49.286	Oryctolagus_cuniculus
ENSG00000125207	PIWIL1	99	49.649	ENSOCUG00000017781	PIWIL3	99	49.363	Oryctolagus_cuniculus
ENSG00000125207	PIWIL1	98	60.921	ENSORLG00000013695	piwil1	99	61.934	Oryzias_latipes
ENSG00000125207	PIWIL1	88	42.202	ENSORLG00000013656	piwil2	68	42.202	Oryzias_latipes
ENSG00000125207	PIWIL1	98	60.921	ENSORLG00020002279	piwil1	98	61.275	Oryzias_latipes_hni
ENSG00000125207	PIWIL1	88	42.333	ENSORLG00020010494	piwil2	73	42.333	Oryzias_latipes_hni
ENSG00000125207	PIWIL1	98	60.803	ENSORLG00015015958	piwil1	98	61.157	Oryzias_latipes_hsok
ENSG00000125207	PIWIL1	88	42.333	ENSORLG00015018666	piwil2	73	42.333	Oryzias_latipes_hsok
ENSG00000125207	PIWIL1	98	60.921	ENSOMEG00000015298	piwil1	99	61.118	Oryzias_melastigma
ENSG00000125207	PIWIL1	88	41.754	ENSOMEG00000018436	piwil2	76	41.754	Oryzias_melastigma
ENSG00000125207	PIWIL1	90	51.341	ENSOGAG00000012156	PIWIL4	97	49.281	Otolemur_garnettii
ENSG00000125207	PIWIL1	100	96.288	ENSOGAG00000015400	PIWIL1	100	96.288	Otolemur_garnettii
ENSG00000125207	PIWIL1	88	42.857	ENSOGAG00000004913	PIWIL2	78	42.857	Otolemur_garnettii
ENSG00000125207	PIWIL1	90	41.869	ENSOARG00000010357	PIWIL2	80	41.869	Ovis_aries
ENSG00000125207	PIWIL1	99	47.168	ENSOARG00000009613	PIWIL4	99	47.337	Ovis_aries
ENSG00000125207	PIWIL1	100	91.329	ENSOARG00000016263	PIWIL1	100	83.422	Ovis_aries
ENSG00000125207	PIWIL1	100	50.569	ENSOARG00000018486	PIWIL3	99	53.129	Ovis_aries
ENSG00000125207	PIWIL1	100	100.000	ENSPPAG00000018598	PIWIL1	100	99.535	Pan_paniscus
ENSG00000125207	PIWIL1	97	50.526	ENSPPAG00000031985	PIWIL3	97	50.643	Pan_paniscus
ENSG00000125207	PIWIL1	88	42.595	ENSPPAG00000033460	PIWIL2	78	42.595	Pan_paniscus
ENSG00000125207	PIWIL1	100	49.249	ENSPPAG00000031181	PIWIL4	98	49.525	Pan_paniscus
ENSG00000125207	PIWIL1	98	95.272	ENSPPRG00000001911	PIWIL1	98	95.272	Panthera_pardus
ENSG00000125207	PIWIL1	89	56.736	ENSPPRG00000011117	PIWIL3	100	56.736	Panthera_pardus
ENSG00000125207	PIWIL1	96	49.157	ENSPPRG00000007432	PIWIL4	98	49.157	Panthera_pardus
ENSG00000125207	PIWIL1	88	40.576	ENSPPRG00000000518	PIWIL2	77	40.576	Panthera_pardus
ENSG00000125207	PIWIL1	88	42.670	ENSPTIG00000019334	PIWIL2	78	42.670	Panthera_tigris_altaica
ENSG00000125207	PIWIL1	96	49.157	ENSPTIG00000020931	PIWIL4	99	49.157	Panthera_tigris_altaica
ENSG00000125207	PIWIL1	92	54.680	ENSPTIG00000009971	PIWIL3	100	56.606	Panthera_tigris_altaica
ENSG00000125207	PIWIL1	98	95.508	ENSPTIG00000005342	PIWIL1	98	95.508	Panthera_tigris_altaica
ENSG00000125207	PIWIL1	100	49.015	ENSPTRG00000004187	PIWIL4	93	51.192	Pan_troglodytes
ENSG00000125207	PIWIL1	97	50.643	ENSPTRG00000014180	PIWIL3	97	50.760	Pan_troglodytes
ENSG00000125207	PIWIL1	88	42.782	ENSPTRG00000022613	PIWIL2	78	42.782	Pan_troglodytes
ENSG00000125207	PIWIL1	100	100.000	ENSPTRG00000005633	PIWIL1	100	99.535	Pan_troglodytes
ENSG00000125207	PIWIL1	100	48.956	ENSPANG00000016066	PIWIL4	92	51.523	Papio_anubis
ENSG00000125207	PIWIL1	100	98.722	ENSPANG00000003836	PIWIL1	100	98.722	Papio_anubis
ENSG00000125207	PIWIL1	88	42.782	ENSPANG00000018061	PIWIL2	78	42.782	Papio_anubis
ENSG00000125207	PIWIL1	97	48.763	ENSPANG00000022557	PIWIL3	96	48.763	Papio_anubis
ENSG00000125207	PIWIL1	88	43.701	ENSPKIG00000025025	piwil2	78	43.701	Paramormyrops_kingsleyae
ENSG00000125207	PIWIL1	95	64.548	ENSPKIG00000008517	piwil1	97	64.183	Paramormyrops_kingsleyae
ENSG00000125207	PIWIL1	92	53.199	ENSPSIG00000014155	PIWIL4	94	53.199	Pelodiscus_sinensis
ENSG00000125207	PIWIL1	76	73.282	ENSPSIG00000011944	PIWIL1	96	74.781	Pelodiscus_sinensis
ENSG00000125207	PIWIL1	62	63.551	ENSPMGG00000009085	piwil1	78	64.184	Periophthalmus_magnuspinnatus
ENSG00000125207	PIWIL1	98	94.687	ENSPEMG00000019053	Piwil1	98	94.687	Peromyscus_maniculatus_bairdii
ENSG00000125207	PIWIL1	88	42.857	ENSPEMG00000021798	Piwil2	78	42.857	Peromyscus_maniculatus_bairdii
ENSG00000125207	PIWIL1	100	49.421	ENSPEMG00000023859	Piwil4	97	49.820	Peromyscus_maniculatus_bairdii
ENSG00000125207	PIWIL1	98	51.111	ENSPMAG00000009302	piwil1	97	51.111	Petromyzon_marinus
ENSG00000125207	PIWIL1	88	40.891	ENSPMAG00000001669	piwil2	98	40.891	Petromyzon_marinus
ENSG00000125207	PIWIL1	88	43.381	ENSPCIG00000012698	PIWIL2	78	43.381	Phascolarctos_cinereus
ENSG00000125207	PIWIL1	100	49.072	ENSPCIG00000030600	PIWIL4	92	51.142	Phascolarctos_cinereus
ENSG00000125207	PIWIL1	98	91.608	ENSPCIG00000021062	PIWIL1	98	91.608	Phascolarctos_cinereus
ENSG00000125207	PIWIL1	96	56.818	ENSPCIG00000021061	-	85	56.818	Phascolarctos_cinereus
ENSG00000125207	PIWIL1	82	42.172	ENSPFOG00000012110	piwil2	68	42.172	Poecilia_formosa
ENSG00000125207	PIWIL1	95	63.126	ENSPFOG00000016960	piwil1	98	62.411	Poecilia_formosa
ENSG00000125207	PIWIL1	88	41.361	ENSPLAG00000014526	piwil2	72	41.361	Poecilia_latipinna
ENSG00000125207	PIWIL1	95	63.126	ENSPLAG00000007206	piwil1	98	62.278	Poecilia_latipinna
ENSG00000125207	PIWIL1	95	63.126	ENSPMEG00000003010	piwil1	99	62.136	Poecilia_mexicana
ENSG00000125207	PIWIL1	88	41.361	ENSPMEG00000018897	piwil2	72	41.361	Poecilia_mexicana
ENSG00000125207	PIWIL1	89	41.688	ENSPREG00000019700	piwil2	72	41.688	Poecilia_reticulata
ENSG00000125207	PIWIL1	92	63.019	ENSPREG00000001990	piwil1	95	63.019	Poecilia_reticulata
ENSG00000125207	PIWIL1	100	99.071	ENSPPYG00000005121	PIWIL1	100	99.071	Pongo_abelii
ENSG00000125207	PIWIL1	97	50.587	ENSPPYG00000011653	PIWIL3	97	50.587	Pongo_abelii
ENSG00000125207	PIWIL1	100	48.902	ENSPPYG00000003783	PIWIL4	98	49.171	Pongo_abelii
ENSG00000125207	PIWIL1	88	42.520	ENSPPYG00000018420	PIWIL2	78	42.520	Pongo_abelii
ENSG00000125207	PIWIL1	100	89.535	ENSPCAG00000002106	PIWIL1	76	98.039	Procavia_capensis
ENSG00000125207	PIWIL1	70	66.667	ENSPCAG00000014859	PIWIL2	62	66.667	Procavia_capensis
ENSG00000125207	PIWIL1	88	43.250	ENSPCOG00000019344	PIWIL2	78	43.250	Propithecus_coquereli
ENSG00000125207	PIWIL1	100	92.486	ENSPCOG00000007411	PIWIL1	98	90.813	Propithecus_coquereli
ENSG00000125207	PIWIL1	100	49.080	ENSPCOG00000022264	PIWIL4	93	51.633	Propithecus_coquereli
ENSG00000125207	PIWIL1	100	45.809	ENSPVAG00000007245	PIWIL4	97	46.539	Pteropus_vampyrus
ENSG00000125207	PIWIL1	82	68.404	ENSPVAG00000016875	PIWIL3	80	68.404	Pteropus_vampyrus
ENSG00000125207	PIWIL1	82	48.792	ENSPVAG00000009878	PIWIL2	76	48.792	Pteropus_vampyrus
ENSG00000125207	PIWIL1	98	89.716	ENSPVAG00000010030	PIWIL1	98	89.716	Pteropus_vampyrus
ENSG00000125207	PIWIL1	93	63.151	ENSPNYG00000019750	piwil1	93	63.151	Pundamilia_nyererei
ENSG00000125207	PIWIL1	99	39.572	ENSPNYG00000003305	piwil2	95	49.462	Pundamilia_nyererei
ENSG00000125207	PIWIL1	88	43.644	ENSPNAG00000004662	piwil2	72	43.644	Pygocentrus_nattereri
ENSG00000125207	PIWIL1	96	65.371	ENSPNAG00000012989	piwil1	99	64.614	Pygocentrus_nattereri
ENSG00000125207	PIWIL1	98	94.805	ENSRNOG00000000934	Piwil1	98	94.805	Rattus_norvegicus
ENSG00000125207	PIWIL1	100	49.537	ENSRNOG00000009043	Piwil4	99	50.962	Rattus_norvegicus
ENSG00000125207	PIWIL1	88	42.988	ENSRNOG00000009871	Piwil2	78	42.988	Rattus_norvegicus
ENSG00000125207	PIWIL1	100	48.902	ENSRBIG00000039745	PIWIL4	93	51.064	Rhinopithecus_bieti
ENSG00000125207	PIWIL1	67	44.483	ENSRBIG00000042426	PIWIL2	96	44.483	Rhinopithecus_bieti
ENSG00000125207	PIWIL1	100	98.722	ENSRBIG00000004595	PIWIL1	100	98.722	Rhinopithecus_bieti
ENSG00000125207	PIWIL1	100	48.902	ENSRROG00000015073	PIWIL4	98	49.171	Rhinopithecus_roxellana
ENSG00000125207	PIWIL1	100	98.722	ENSRROG00000030794	PIWIL1	100	98.722	Rhinopithecus_roxellana
ENSG00000125207	PIWIL1	88	42.651	ENSRROG00000037847	PIWIL2	78	42.651	Rhinopithecus_roxellana
ENSG00000125207	PIWIL1	100	49.213	ENSSBOG00000005485	PIWIL3	99	51.963	Saimiri_boliviensis_boliviensis
ENSG00000125207	PIWIL1	100	96.167	ENSSBOG00000033094	PIWIL1	100	96.167	Saimiri_boliviensis_boliviensis
ENSG00000125207	PIWIL1	92	51.500	ENSSBOG00000024534	PIWIL4	98	61.878	Saimiri_boliviensis_boliviensis
ENSG00000125207	PIWIL1	78	47.453	ENSSBOG00000030819	PIWIL2	76	47.453	Saimiri_boliviensis_boliviensis
ENSG00000125207	PIWIL1	100	47.876	ENSSHAG00000017415	PIWIL4	96	48.916	Sarcophilus_harrisii
ENSG00000125207	PIWIL1	88	43.081	ENSSHAG00000018279	PIWIL2	78	43.081	Sarcophilus_harrisii
ENSG00000125207	PIWIL1	98	92.217	ENSSHAG00000016260	PIWIL1	98	92.217	Sarcophilus_harrisii
ENSG00000125207	PIWIL1	59	51.473	ENSSHAG00000016064	-	96	51.473	Sarcophilus_harrisii
ENSG00000125207	PIWIL1	88	41.307	ENSSFOG00015012930	piwil2	65	41.307	Scleropages_formosus
ENSG00000125207	PIWIL1	100	62.834	ENSSFOG00015005758	piwil1	99	63.108	Scleropages_formosus
ENSG00000125207	PIWIL1	100	61.618	ENSSMAG00000002912	piwil1	98	61.722	Scophthalmus_maximus
ENSG00000125207	PIWIL1	89	40.903	ENSSMAG00000019263	piwil2	72	40.903	Scophthalmus_maximus
ENSG00000125207	PIWIL1	89	42.318	ENSSDUG00000001859	piwil2	72	42.318	Seriola_dumerili
ENSG00000125207	PIWIL1	95	64.591	ENSSDUG00000022636	piwil1	99	63.913	Seriola_dumerili
ENSG00000125207	PIWIL1	89	42.448	ENSSLDG00000017738	piwil2	97	48.399	Seriola_lalandi_dorsalis
ENSG00000125207	PIWIL1	93	63.625	ENSSLDG00000013757	piwil1	95	63.625	Seriola_lalandi_dorsalis
ENSG00000125207	PIWIL1	56	73.418	ENSSARG00000009859	-	61	73.418	Sorex_araneus
ENSG00000125207	PIWIL1	90	96.010	ENSSARG00000002678	PIWIL1	100	96.010	Sorex_araneus
ENSG00000125207	PIWIL1	81	43.384	ENSSARG00000013686	PIWIL2	79	43.384	Sorex_araneus
ENSG00000125207	PIWIL1	88	43.775	ENSSPUG00000014427	PIWIL2	94	52.347	Sphenodon_punctatus
ENSG00000125207	PIWIL1	93	79.046	ENSSPUG00000013448	PIWIL1	94	78.634	Sphenodon_punctatus
ENSG00000125207	PIWIL1	93	51.368	ENSSPUG00000004259	PIWIL4	99	49.024	Sphenodon_punctatus
ENSG00000125207	PIWIL1	88	63.061	ENSSPAG00000013460	piwil1	97	61.705	Stegastes_partitus
ENSG00000125207	PIWIL1	99	39.562	ENSSPAG00000019925	piwil2	91	40.048	Stegastes_partitus
ENSG00000125207	PIWIL1	100	96.283	ENSSSCG00000009749	PIWIL1	100	96.283	Sus_scrofa
ENSG00000125207	PIWIL1	92	49.875	ENSSSCG00000009950	-	98	49.875	Sus_scrofa
ENSG00000125207	PIWIL1	100	49.711	ENSSSCG00000014959	PIWIL4	99	49.706	Sus_scrofa
ENSG00000125207	PIWIL1	88	42.595	ENSSSCG00000030228	PIWIL2	77	42.595	Sus_scrofa
ENSG00000125207	PIWIL1	56	31.365	ENSTGUG00000014388	-	99	31.365	Taeniopygia_guttata
ENSG00000125207	PIWIL1	93	73.810	ENSTGUG00000004779	PIWIL1	99	73.810	Taeniopygia_guttata
ENSG00000125207	PIWIL1	88	42.988	ENSTRUG00000012599	piwil2	73	42.988	Takifugu_rubripes
ENSG00000125207	PIWIL1	95	63.183	ENSTRUG00000011149	piwil1	99	62.273	Takifugu_rubripes
ENSG00000125207	PIWIL1	88	42.003	ENSTNIG00000016749	piwil2	100	42.003	Tetraodon_nigroviridis
ENSG00000125207	PIWIL1	98	60.782	ENSTNIG00000003089	piwil1	98	60.782	Tetraodon_nigroviridis
ENSG00000125207	PIWIL1	90	49.871	ENSTBEG00000013343	PIWIL4	88	49.871	Tupaia_belangeri
ENSG00000125207	PIWIL1	60	44.898	ENSTBEG00000012061	-	64	44.898	Tupaia_belangeri
ENSG00000125207	PIWIL1	76	59.155	ENSTTRG00000012746	PIWIL2	68	59.155	Tursiops_truncatus
ENSG00000125207	PIWIL1	97	48.038	ENSTTRG00000010546	PIWIL4	98	48.219	Tursiops_truncatus
ENSG00000125207	PIWIL1	98	92.790	ENSTTRG00000016994	PIWIL1	98	92.790	Tursiops_truncatus
ENSG00000125207	PIWIL1	100	48.028	ENSUAMG00000021173	PIWIL4	97	48.317	Ursus_americanus
ENSG00000125207	PIWIL1	98	95.981	ENSUAMG00000000604	PIWIL1	98	95.981	Ursus_americanus
ENSG00000125207	PIWIL1	100	49.366	ENSUMAG00000007117	PIWIL4	97	50.000	Ursus_maritimus
ENSG00000125207	PIWIL1	98	95.981	ENSUMAG00000020294	PIWIL1	98	95.981	Ursus_maritimus
ENSG00000125207	PIWIL1	88	43.455	ENSUMAG00000005016	PIWIL2	80	42.857	Ursus_maritimus
ENSG00000125207	PIWIL1	88	42.857	ENSVPAG00000010581	PIWIL2	78	42.857	Vicugna_pacos
ENSG00000125207	PIWIL1	97	44.352	ENSVPAG00000005839	PIWIL4	98	44.352	Vicugna_pacos
ENSG00000125207	PIWIL1	94	50.801	ENSVVUG00000011577	PIWIL4	98	50.801	Vulpes_vulpes
ENSG00000125207	PIWIL1	98	95.745	ENSVVUG00000025695	PIWIL1	89	95.745	Vulpes_vulpes
ENSG00000125207	PIWIL1	88	43.045	ENSVVUG00000005239	PIWIL2	78	43.045	Vulpes_vulpes
ENSG00000125207	PIWIL1	88	43.832	ENSXETG00000010533	piwil2	80	43.832	Xenopus_tropicalis
ENSG00000125207	PIWIL1	92	47.875	ENSXETG00000006411	piwil4	100	47.875	Xenopus_tropicalis
ENSG00000125207	PIWIL1	97	65.493	ENSXETG00000012572	piwil3	98	65.493	Xenopus_tropicalis
ENSG00000125207	PIWIL1	88	40.838	ENSXCOG00000015207	piwil2	95	48.746	Xiphophorus_couchianus
ENSG00000125207	PIWIL1	93	62.861	ENSXMAG00000000110	piwil1	99	61.818	Xiphophorus_maculatus
ENSG00000125207	PIWIL1	88	40.838	ENSXMAG00000005034	piwil2	72	40.838	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003727	single-stranded RNA binding	-	IEA	Function
GO:0003729	mRNA binding	-	ISS	Function
GO:0004521	endoribonuclease activity	-	ISS	Function
GO:0005515	protein binding	14749716.20937909.	IPI	Function
GO:0005634	nucleus	-	IEA	Component
GO:0005737	cytoplasm	-	ISS	Component
GO:0006417	regulation of translation	-	IEA	Process
GO:0007275	multicellular organism development	-	IEA	Process
GO:0007283	spermatogenesis	-	ISS	Process
GO:0007286	spermatid development	28552346.	IMP	Process
GO:0007286	spermatid development	-	ISS	Process
GO:0010529	negative regulation of transposition	-	ISS	Process
GO:0019901	protein kinase binding	-	IEA	Function
GO:0031047	gene silencing by RNA	-	ISS	Process
GO:0033391	chromatoid body	-	ISS	Component
GO:0034584	piRNA binding	28552346.	IDA	Function
GO:0034587	piRNA metabolic process	-	ISS	Process
GO:0035093	spermatogenesis, exchange of chromosomal proteins	-	ISS	Process
GO:0043186	P granule	-	ISS	Component
GO:0046872	metal ion binding	-	IEA	Function
GO:0051321	meiotic cell cycle	-	IEA	Process
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	-	IEA	Process
GO:0097433	dense body	-	IEA	Component
GO:0140262	mRNA cap binding complex binding	-	IEA	Function
GO:1905538	polysome binding	-	IEA	Function

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
16953229	Expression of the stem cell self-renewal gene Hiwi and risk of tumour-related death in patients with soft-tissue sarcoma.	Oncogene	2007 Feb 15	Taubert H	-
24532429	Aberrant expression of DPPA2 and HIWI genes in colorectal cancer and their impacts on poor prognosis.	Tumour Biol	2014 Jun	Raeisossadati R	doi: 10.1007/s13277-014-1690-x
30226604	Epigenetic roles of PIWIinteracting RNAs (piRNAs) in cancer metastasis (Review).	Oncol Rep	2018 Nov	Liu J	doi: 10.3892/or.2018.6684
25119492	Hiwi facilitates chemoresistance as a cancer stem cell marker in cervical cancer.	Oncol Rep	2014 Nov	Liu W	doi: 10.3892/or.2014.3401
26847393	High expression of piwi-like RNA-mediated gene silencing 1 is associated with poor prognosis via regulating transforming growth factor-β receptors and cyclin-dependent kinases in breast cancer.	Mol Med Rep	2016 Mar	Cao J	doi: 10.3892/mmr.2016.4842
16287078	Expression of hiwi gene in human gastric cancer was associated with proliferation of cancer cells.	Int J Cancer	2006 Apr 15	Liu X	-
28634417	Expression Status of PIWIL1 as a Prognostic Marker of Colorectal Cancer.	Dis Markers	2017	Sun R	doi: 10.1155/2017/1204937
30598579	Piwi like RNA-mediated gene silencing 1 gene as a possible major player in gastric cancer.	World J Gastroenterol	2018 Dec 21	Ara??jo T	doi: 10.3748/wjg.v24.i47.5338.
30616319	[Differential expressions analysis of piwi-interacting RNAs in hepatocellular carcinoma].	Zhonghua Gan Zang Bing Za Zhi	2018 Nov 20	Miao PZ	doi: 10.3760/cma.j.issn.1007-3418.2018.11.007.
24602614	Detection of PIWI and piRNAs in the mitochondria of mammalian cancer cells.	Biochem Biophys Res Commun	2014 Mar 28	Kwon C	doi: 10.1016/j.bbrc.2014.02.112
25292027	Overexpression of hiwi promotes growth of human breast cancer cells.	Asian Pac J Cancer Prev	2014	Wang DW	-
22591718	RASSF1C modulates the expression of a stem cell renewal gene, PIWIL1.	BMC Res Notes	2012 May 16	Reeves ME	doi: 10.1186/1756-0500-5-239.
25313140	RNA sequencing identifies specific PIWI-interacting small non-coding RNA expression patterns in breast cancer.	Oncotarget	2014 Oct 30	Hashim A	-
25742785	The significance of PIWI family expression in human lung embryogenesis and non-small cell lung cancer.	Oncotarget	2015 Oct 13	Navarro A	doi: 10.18632/oncotarget.3003.
20204292	The universal overexpression of a cancer testis antigen hiwi is associated with cancer angiogenesis.	Oncol Rep	2010 Apr	Li S	-
26026091	Correlation of HIWI and HILI Expression with Cancer Stem Cell Markers in Colorectal Cancer.	Anticancer Res	2015 Jun	Litwin M	-
19995427	Expression of HIWI in human esophageal squamous cell carcinoma is significantly associated with poorer prognosis.	BMC Cancer	2009 Dec 8	He W	doi: 10.1186/1471-2407-9-426.
20502058	Expression of PSCA, PIWIL1, and TBX2 in endometrial adenocarcinoma.	Onkologie	2010	Liu WK	doi: 10.1159/000305098
21933617	HIWI expression profile in cancer cells and its prognostic value for patients with colorectal cancer.	Chin Med J (Engl)	2011 Jul	Zeng Y	-
22670175	The PIWI protein acts as a predictive marker for human gastric cancer.	Int J Clin Exp Pathol	2012	Wang Y	-
22261620	Combined phenotype of 4 markers improves prognostic value of patients with colon cancer.	Am J Med Sci	2012 Apr	Liu C	doi: 10.1097/MAJ.0b013e31822cb4cd.
29599319	Aberrant Expression of PIWIL1 and PIWIL2 and Their Clinical Significance in Ductal Breast Carcinoma.	Anticancer Res	2018 Apr	Litwin M	-

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr12	130345794	Missense_Mutation	novel	E78K	0.37
BLCA	chr12	130348167	Missense_Mutation	novel	D240N	0.15
BLCA	chr12	130371491	Missense_Mutation	NA	R827C	0.36	PAZ
BLCA	chr12	130345851	Silent	rs762300056	L97L	0.15
BLCA	chr12	130355001	Missense_Mutation	NA	H429Y	0.44
BLCA	chr12	130354631	Missense_Mutation	NA	A380G	0.3
BLCA	chr12	130367188	Nonsense_Mutation	novel	Q751*	0.39	PAZ
BLCA	chr12	130346533	Nonsense_Mutation	novel	C160*	0.35
BLCA	chr12	130349328	Missense_Mutation	rs771090876	R275Q	0.51
BLCA	chr12	130345847	Silent	NA	Q95Q	0.18
BLCA	chr12	130363052	Silent	rs143082104	R701R	0.28
BLCA	chr12	130349912	Missense_Mutation	rs751456474	S330N	0.22
BLCA	chr12	130361552	Missense_Mutation	NA	R641W	0.12	PAZ
BLCA	chr12	130363053	Missense_Mutation	NA	D702N	0.23	PAZ
BLCA	chr12	130348137	Nonsense_Mutation	rs369068461	R230*	0.14
BRCA	chr12	130346982	Silent	NA	V191V	0.25
BRCA	chr12	130371503	Missense_Mutation	NA	P831A	0.09	PAZ
BRCA	chr12	130354983	Nonsense_Mutation	rs750875858	R423*	0.11
BRCA	chr12	130371668	3'UTR	novel		0.31
BRCA	chr12	130371668	3'UTR	novel		0.59
BRCA	chr12	130342599	Missense_Mutation	NA	G3E	0.28
BRCA	chr12	130362823	Missense_Mutation	novel	K676N	0.18	PAZ
BRCA	chr12	130361359	Missense_Mutation	novel	E615D	0.08	PAZ
BRCA	chr12	130362776	Missense_Mutation	rs778496528	R661C	0.13	PAZ
BRCA	chr12	130361309	Missense_Mutation	novel	A599S	0.06	PAZ
BRCA	chr12	130354549	Missense_Mutation	NA	E353Q	0.36
BRCA	chr12	130354622	Missense_Mutation	NA	P377Q	0.56
BRCA	chr12	130342659	Missense_Mutation	NA	G23D	0.16
BRCA	chr12	130343011	Nonsense_Mutation	NA	Q34*	0.33
BRCA	chr12	130361227	Frame_Shift_Ins	novel	*Y574Ifs63**	0.11	PAZ
BRCA	chr12	130349876	Missense_Mutation	NA	R318T	0.14
BRCA	chr12	130342614	Missense_Mutation	NA	R8T	0.16
BRCA	chr12	130354972	Missense_Mutation	rs138419869	R419H	0.15
BRCA	chr12	130349929	Missense_Mutation	rs769712838	D336N	0.3
BRCA	chr12	130349327	Nonsense_Mutation	NA	R275*	0.13
BRCA	chr12	130371182	Frame_Shift_Ins	NA	*I779Yfs10**	0.16	PAZ
BRCA	chr12	130343062	Missense_Mutation	rs144603967	R51W	0.22
BRCA	chr12	130342632	Missense_Mutation	NA	R14H	0.32
BRCA	chr12	130349405	Missense_Mutation	NA	K301E	0.34
CESC	chr12	130371668	3'UTR	novel		0.53
CESC	chr12	130343023	Nonsense_Mutation	rs777599866	Q38*	0.35
CESC	chr12	130371573	Missense_Mutation	NA	L854P	0.3
CESC	chr12	130343074	Missense_Mutation	novel	T55P	0.08
CESC	chr12	130346991	Silent	rs759488848	T194T	0.33
CESC	chr12	130349926	Missense_Mutation	novel	A335S	0.48
CESC	chr12	130371281	Missense_Mutation	NA	Q809H	0.22	PAZ
CESC	chr12	130371717	3'UTR	novel		0.58
CESC	chr12	130349375	Missense_Mutation	novel	E291K	0.25
CESC	chr12	130371632	3'UTR	novel		0.29
CESC	chr12	130343012	Missense_Mutation	rs767074367	Q34R	0.39
CESC	chr12	130357527	Nonsense_Mutation	NA	Q547*	0.45
COAD	chr12	130354600	Missense_Mutation	rs200413984	R370W	0.44
COAD	chr12	130357498	Missense_Mutation	NA	R537K	0.29
COAD	chr12	130354983	Nonsense_Mutation	rs750875858	R423*	0.4
COAD	chr12	130361296	Silent	NA	Q594Q	0.11
COAD	chr12	130354906	Missense_Mutation	NA	R397H	0.45
COAD	chr12	130371515	Missense_Mutation	NA	A835T	0.13	PAZ
COAD	chr12	130349928	Silent	rs746113660	A335A	0.13
COAD	chr12	130342670	Splice_Site	NA	X26_splice	0.39
COAD	chr12	130371668	3'UTR	novel		0.38
COAD	chr12	130361601	Missense_Mutation	rs199654827	R657H	0.39	PAZ
COAD	chr12	130371257	Silent	rs150359032	S801S	0.36
COAD	chr12	130371668	3'UTR	novel		0.13
COAD	chr12	130361228	Frame_Shift_Del	NA	*K573Nfs19**	0.3	PAZ
COAD	chr12	130371647	3'UTR	novel		0.32
COAD	chr12	130349369	Nonsense_Mutation	NA	Q289*	0.23
COAD	chr12	130343063	Missense_Mutation	rs764559881	R51Q	0.12
COAD	chr12	130367144	Missense_Mutation	rs117506395	T736M	0.13	PAZ
COAD	chr12	130354631	Missense_Mutation	novel	A380V	0.09
COAD	chr12	130362797	Nonsense_Mutation	novel	G668*	0.16	PAZ
COAD	chr12	130363067	Silent	rs781168048	D706D	0.22
COAD	chr12	130367144	Missense_Mutation	rs117506395	T736M	0.12	PAZ
COAD	chr12	130354609	Frame_Shift_Del	novel	*T375Hfs18**	0.35
COAD	chr12	130354906	Missense_Mutation	NA	R397H	0.49
COAD	chr12	130363106	Frame_Shift_Ins	NA	*L721Ffs9**	0.32	PAZ
COAD	chr12	130371668	3'UTR	novel		0.77
COAD	chr12	130361381	Splice_Site	rs761727169	X622_splice	0.2
COAD	chr12	130345771	Missense_Mutation	NA	G70E	0.3
COAD	chr12	130349319	Missense_Mutation	novel	K272T	0.07
COAD	chr12	130356993	Missense_Mutation	novel	D494Y	0.16
COAD	chr12	130357513	Missense_Mutation	NA	L542S	0.27
COAD	chr12	130371182	Frame_Shift_Ins	NA	*I779Yfs10**	0.27	PAZ
COAD	chr12	130371668	3'UTR	novel		0.39
COAD	chr12	130346551	Silent	rs372419033	T166T	0.21
COAD	chr12	130371647	3'UTR	novel		0.17
COAD	chr12	130345810	Missense_Mutation	rs201447253	R83H	0.12
DLBC	chr12	130371668	3'UTR	novel		0.23
DLBC	chr12	130363044	Missense_Mutation	novel	V699M	0.33	PAZ
DLBC	chr12	130371214	Missense_Mutation	novel	G787V	0.22	PAZ
DLBC	chr12	130371282	Missense_Mutation	novel	R810C	0.2	PAZ
ESCA	chr12	130371668	3'UTR	novel		0.38
ESCA	chr12	130349359	Silent	novel	N285N	0.16
ESCA	chr12	130349307	Missense_Mutation	novel	D268G	0.19
ESCA	chr12	130349266	Silent	novel	T254T	0.37
ESCA	chr12	130361222	Missense_Mutation	novel	A570T	0.3	PAZ
ESCA	chr12	130362820	Silent	novel	L675L	0.05
GBM	chr12	130346424	Missense_Mutation	rs772560236	R124H	0.31
GBM	chr12	130342664	Missense_Mutation	novel	T25S	0.48
GBM	chr12	130361263	Silent	novel	S583S	0.06
GBM	chr12	130363094	Silent	rs188915650	Y715Y	0.44
GBM	chr12	130349313	Missense_Mutation	novel	S270N	0.09
GBM	chr12	130361217	Missense_Mutation	novel	Y568C	0.1	PAZ
GBM	chr12	130363061	Silent	NA	V704V	0.54
GBM	chr12	130361279	Nonsense_Mutation	rs767847661	R589*	0.53	PAZ
GBM	chr12	130354924	Missense_Mutation	novel	M403R	0.15
GBM	chr12	130371511	Frame_Shift_Ins	novel	*Y834Ifs41**	0.04	PAZ
GBM	chr12	130349338	Silent	NA	T278T	0.35
GBM	chr12	130371334	Intron	novel		0.23
GBM	chr12	130357018	Missense_Mutation	rs778735608	R502Q	0.31
GBM	chr12	130354600	Missense_Mutation	rs200413984	R370W	0.5
GBM	chr12	130347062	Missense_Mutation	NA	R218T	0.47
GBM	chr12	130346493	Nonsense_Mutation	novel	S147*	0.07
HNSC	chr12	130367181	Missense_Mutation	novel	F748L	0.19	PAZ
HNSC	chr12	130342633	Silent	rs766374504	R14R	0.21
HNSC	chr12	130362992	Splice_Region	rs200510720	A681A	0.29
HNSC	chr12	130371739	3'UTR	novel		0.56
HNSC	chr12	130343045	Missense_Mutation	novel	E45V	0.13
HNSC	chr12	130357001	Nonsense_Mutation	novel	W496*	0.33
HNSC	chr12	130355579	Missense_Mutation	rs552222799	R439Q	0.09
HNSC	chr12	130346996	Missense_Mutation	novel	T196N	0.11
HNSC	chr12	130347017	Missense_Mutation	novel	P203H	0.32
HNSC	chr12	130343094	Silent	NA	K61K	0.38
HNSC	chr12	130349393	Missense_Mutation	novel	E297Q	0.1
HNSC	chr12	130363044	Missense_Mutation	novel	V699M	0.15	PAZ
KIRC	chr12	130363070	Silent	NA	G707G	0.05
KIRC	chr12	130363028	Missense_Mutation	NA	M693I	0.36	PAZ
KIRC	chr12	130354614	Silent	NA	G374G	0.28
KIRC	chr12	130361199	Frame_Shift_Del	novel	*S562Ifs30**	0.09	PAZ
KIRC	chr12	130371567	Frame_Shift_Ins	novel	*L854Ifs28**	0.05
KIRC	chr12	130361283	Missense_Mutation	NA	T590N	0.42	PAZ
LAML	chr12	130355629	Frame_Shift_Ins	novel	*L457Ffs14**	0.06
LGG	chr12	130361524	Silent	rs35377726	I631I	0.12
LGG	chr12	130371314	Silent	rs775558906	Y820Y	0.45
LIHC	chr12	130348145	Silent	novel	Y232Y	0.45
LIHC	chr12	130357530	Missense_Mutation	NA	K548E	0.13
LIHC	chr12	130349862	Silent	NA	N313N	0.52
LIHC	chr12	130345841	Silent	rs752244660	T93T	0.18
LIHC	chr12	130343067	Missense_Mutation	NA	Q52H	0.17
LIHC	chr12	130354609	Frame_Shift_Del	novel	*T375Hfs18**	0.35
LUAD	chr12	130354610	Missense_Mutation	novel	G373V	0.09
LUAD	chr12	130357079	Missense_Mutation	NA	M522I	0.26
LUAD	chr12	130361257	Silent	NA	T581T	0.2
LUAD	chr12	130371365	Intron	novel		0.51
LUAD	chr12	130347045	Nonsense_Mutation	NA	Y212*	0.37
LUAD	chr12	130371657	3'UTR	novel		0.76
LUAD	chr12	130346584	Missense_Mutation	NA	K177N	0.42
LUAD	chr12	130357516	Missense_Mutation	NA	R543K	0.24
LUAD	chr12	130357017	Nonsense_Mutation	rs754777604	R502*	0.24
LUAD	chr12	130363037	Silent	novel	R696R	0.18
LUAD	chr12	130343003	Missense_Mutation	novel	G31V	0.3
LUAD	chr12	130347059	Missense_Mutation	novel	R217M	0.91
LUAD	chr12	130357076	Silent	novel	A521A	0.13
LUAD	chr12	130349351	Missense_Mutation	novel	M283L	0.36
LUAD	chr12	130361330	Silent	NA	L606L	0.17
LUAD	chr12	130361257	Silent	NA	T581T	0.74
LUAD	chr12	130354652	Missense_Mutation	NA	C387F	0.44
LUAD	chr12	130356981	Missense_Mutation	NA	V490F	0.16
LUAD	chr12	130371619	3'UTR	novel		0.19
LUAD	chr12	130346410	Missense_Mutation	NA	F119L	0.22
LUAD	chr12	130355579	Missense_Mutation	rs552222799	R439Q	0.04
LUAD	chr12	130371380	Intron	novel		0.15
LUAD	chr12	130354906	Missense_Mutation	novel	R397L	0.31
LUAD	chr12	130371652	3'UTR	novel		0.06
LUAD	chr12	130371654	3'UTR	novel		0.06
LUAD	chr12	130343011	Nonsense_Mutation	NA	Q34*	0.32
LUAD	chr12	130348167	Missense_Mutation	novel	D240Y	0.08
LUAD	chr12	130363030	Missense_Mutation	NA	P694H	0.27	PAZ
LUSC	chr12	130357488	Missense_Mutation	novel	V534L	0.13
LUSC	chr12	130349391	Missense_Mutation	novel	Q296P	0.41
LUSC	chr12	130357028	Silent	rs748410507	Y505Y	0.29
LUSC	chr12	130363052	Silent	rs143082104	R701R	0.38
LUSC	chr12	130348118	Missense_Mutation	novel	M223I	0.36
LUSC	chr12	130348138	Missense_Mutation	rs751181793	R230Q	0.19
LUSC	chr12	130343096	Nonsense_Mutation	NA	S62*	0.32
LUSC	chr12	130354929	Missense_Mutation	NA	D405Y	0.18
LUSC	chr12	130363106	Frame_Shift_Ins	NA	*L721Ffs9**	0.29	PAZ
LUSC	chr12	130355583	Missense_Mutation	NA	D440E	0.11
LUSC	chr12	130348176	Missense_Mutation	NA	S243C	0.12
LUSC	chr12	130342669	Splice_Region	rs201104805	A26A	0.53
LUSC	chr12	130355603	Missense_Mutation	novel	S447Y	0.15
LUSC	chr12	130362999	Missense_Mutation	novel	R684W	0.13	PAZ
LUSC	chr12	130361509	Silent	novel	V626V	0.32
LUSC	chr12	130346530	Silent	NA	K159K	0.62
LUSC	chr12	130363058	Silent	rs374592795	G703G	0.24
LUSC	chr12	130348178	Missense_Mutation	novel	S243R	0.25
LUSC	chr12	130357099	Missense_Mutation	novel	A529E	0.36
LUSC	chr12	130343032	Missense_Mutation	rs370704151	P41T	0.61
LUSC	chr12	130371562	Silent	novel	P850P	0.37
LUSC	chr12	130346501	Missense_Mutation	NA	L150I	0.26
LUSC	chr12	130354920	Missense_Mutation	rs778109943	V402M	0.23
LUSC	chr12	130361335	Missense_Mutation	NA	Q607H	0.4	PAZ
LUSC	chr12	130357094	Missense_Mutation	novel	R527S	0.19
LUSC	chr12	130349853	Splice_Region	novel		0.36
LUSC	chr12	130371668	3'UTR	novel		0.24
LUSC	chr12	130348165	Missense_Mutation	rs745440612	I239T	0.12
LUSC	chr12	130355585	Nonsense_Mutation	NA	W441*	0.08
OV	chr12	130355578	Missense_Mutation	NA	R439G	0.39
OV	chr12	130362775	Silent	NA	S660S	0.35
OV	chr12	130345806	Missense_Mutation	novel	R82S	0.07
OV	chr12	130371274	Missense_Mutation	novel	H807L	0.06	PAZ
OV	chr12	130371668	3'UTR	novel		0.1
OV	chr12	130348131	Missense_Mutation	novel	I228V	0.08
OV	chr12	130347040	Missense_Mutation	NA	F211I	0.22
PAAD	chr12	130343062	Missense_Mutation	rs144603967	R51W	0.33
PRAD	chr12	130354983	Nonsense_Mutation	rs750875858	R423*	0.38
PRAD	chr12	130355607	Missense_Mutation	novel	N448K	0.33
PRAD	chr12	130356963	Missense_Mutation	novel	G484C	0.14
PRAD	chr12	130367190	Missense_Mutation	novel	Q751H	0.47	PAZ
PRAD	chr12	130345806	Missense_Mutation	NA	R82C	0.22
PRAD	chr12	130345771	Missense_Mutation	NA	G70E	0.19
PRAD	chr12	130361248	Missense_Mutation	NA	D578E	0.28	PAZ
PRAD	chr12	130342648	Silent	novel	A19A	0.45
READ	chr12	130355558	Missense_Mutation	NA	D432G	0.26
READ	chr12	130346512	Silent	rs766051497	H153H	0.24
READ	chr12	130342632	Missense_Mutation	NA	R14H	0.46
READ	chr12	130371668	3'UTR	novel		0.35
READ	chr12	130367144	Missense_Mutation	rs117506395	T736M	0.35	PAZ
READ	chr12	130349386	Missense_Mutation	novel	K294N	0.35
READ	chr12	130354929	Missense_Mutation	NA	D405Y	0.43
READ	chr12	130356982	Missense_Mutation	NA	V490A	0.56
SARC	chr12	130349868	Missense_Mutation	novel	K315N	0.31
SARC	chr12	130361525	Missense_Mutation	NA	D632N	0.53	PAZ
SARC	chr12	130367233	Missense_Mutation	novel	D766N	0.24	PAZ
SKCM	chr12	130342608	Missense_Mutation	NA	R6Q	0.63
SKCM	chr12	130357506	Missense_Mutation	novel	A540T	0.61
SKCM	chr12	130355650	Missense_Mutation	novel	H463Y	0.37
SKCM	chr12	130371503	Missense_Mutation	NA	P831S	0.3	PAZ
SKCM	chr12	130345786	Missense_Mutation	NA	S75L	0.39
SKCM	chr12	130361338	Missense_Mutation	NA	M608I	0.46	PAZ
SKCM	chr12	130362795	Missense_Mutation	NA	R667K	0.13	PAZ
SKCM	chr12	130347059	Missense_Mutation	novel	R217K	0.41
SKCM	chr12	130347007	Missense_Mutation	NA	E200K	0.11
SKCM	chr12	130356931	Missense_Mutation	NA	P473L	0.49
SKCM	chr12	130361246	Missense_Mutation	NA	D578N	0.43	PAZ
SKCM	chr12	130361554	Silent	rs759666350	R641R	0.12
SKCM	chr12	130371202	Missense_Mutation	NA	A783V	0.39	PAZ
SKCM	chr12	130371491	Missense_Mutation	NA	R827C	0.88	PAZ
SKCM	chr12	130349390	Nonsense_Mutation	NA	Q296*	0.37
SKCM	chr12	130371533	Missense_Mutation	NA	L841F	0.39	PAZ
SKCM	chr12	130371191	Silent	NA	I779I	0.36
SKCM	chr12	130371229	Missense_Mutation	novel	T792K	0.26	PAZ
SKCM	chr12	130371230	Silent	novel	T792T	0.25
SKCM	chr12	130356949	Missense_Mutation	NA	S479F	0.17
SKCM	chr12	130355627	Missense_Mutation	NA	R455K	0.16
SKCM	chr12	130345848	Missense_Mutation	NA	N96H	0.33
SKCM	chr12	130363113	Missense_Mutation	NA	D722N	0.17	PAZ
SKCM	chr12	130346546	Nonsense_Mutation	NA	G165*	0.43
SKCM	chr12	130345776	Nonsense_Mutation	NA	Q72*	0.33
SKCM	chr12	130371380	Intron	novel		0.45
SKCM	chr12	130357018	Missense_Mutation	rs778735608	R502Q	0.13
SKCM	chr12	130361567	Missense_Mutation	NA	G646R	0.23	PAZ
SKCM	chr12	130371252	Missense_Mutation	NA	N800H	0.36	PAZ
SKCM	chr12	130357485	Missense_Mutation	NA	E533K	0.15
SKCM	chr12	130363044	Missense_Mutation	novel	V699M	0.32	PAZ
SKCM	chr12	130361515	Silent	rs761623698	I628I	0.32
SKCM	chr12	130346444	Nonsense_Mutation	NA	Q131*	0.14
SKCM	chr12	130355662	Nonsense_Mutation	NA	K467*	0.11
SKCM	chr12	130343072	Missense_Mutation	NA	G54E	0.28
SKCM	chr12	130357075	Missense_Mutation	novel	A521V	0.69
SKCM	chr12	130371367	Intron	novel		0.44
SKCM	chr12	130357018	Missense_Mutation	rs778735608	R502Q	0.12
SKCM	chr12	130346513	Missense_Mutation	rs369491337	E154K	0.25
SKCM	chr12	130348138	Missense_Mutation	rs751181793	R230Q	0.12
SKCM	chr12	130362817	Silent	novel	G674G	0.75
SKCM	chr12	130371611	3'UTR	novel		0.43
SKCM	chr12	130371191	Silent	NA	I779I	0.28
STAD	chr12	130371668	3'UTR	novel		0.23
STAD	chr12	130349252	Missense_Mutation	novel	P250S	0.17
STAD	chr12	130356926	Nonsense_Mutation	NA	Y471*	0.29
STAD	chr12	130355556	Silent	rs138596008	N431N	0.04
STAD	chr12	130371515	Missense_Mutation	rs745487305	A835S	0.35	PAZ
STAD	chr12	130371224	Silent	NA	S790S	0.2
STAD	chr12	130371668	3'UTR	novel		0.16
STAD	chr12	130371668	3'UTR	novel		0.16
STAD	chr12	130361564	Missense_Mutation	rs753282833	A645T	0.33	PAZ
STAD	chr12	130371182	Frame_Shift_Ins	NA	*I779Yfs10**	0.33	PAZ
STAD	chr12	130371668	3'UTR	novel		0.34
STAD	chr12	130371647	3'UTR	novel		0.3
STAD	chr12	130342584	5'UTR	novel		0.28
STAD	chr12	130349404	Silent	novel	S300S	0.16
STAD	chr12	130371574	Silent	novel	L854L	0.08
STAD	chr12	130361269	Silent	novel	C585C	0.24
STAD	chr12	130371668	3'UTR	novel		0.27
STAD	chr12	130346512	Silent	rs766051497	H153H	0.28
STAD	chr12	130371668	3'UTR	novel		0.4
STAD	chr12	130371668	3'UTR	novel		0.32
STAD	chr12	130349942	Missense_Mutation	NA	V340A	0.1
STAD	chr12	130371668	3'UTR	novel		0.52
STAD	chr12	130371668	3'UTR	novel		0.38
STAD	chr12	130361213	Missense_Mutation	NA	K567E	0.29	PAZ
STAD	chr12	130357523	Silent	NA	L545L	0.25
THYM	chr12	130349932	Missense_Mutation	novel	G337C	0.05
UCEC	chr12	130346513	Missense_Mutation	rs369491337	E154K	0.35
UCEC	chr12	130349910	Missense_Mutation	NA	K329N	0.35
UCEC	chr12	130348138	Missense_Mutation	rs751181793	R230Q	0.32
UCEC	chr12	130349924	Missense_Mutation	novel	K334T	0.51
UCEC	chr12	130363053	Missense_Mutation	NA	D702N	0.27	PAZ
UCEC	chr12	130342588	5'UTR	novel		0.31
UCEC	chr12	130371250	Missense_Mutation	NA	D799G	0.36	PAZ
UCEC	chr12	130356923	Silent	novel	D470D	0.39
UCEC	chr12	130361280	Missense_Mutation	novel	R589Q	0.29	PAZ
UCEC	chr12	130371668	3'UTR	novel		0.43
UCEC	chr12	130349963	Missense_Mutation	novel	R347M	0.45
UCEC	chr12	130371668	3'UTR	novel		0.24
UCEC	chr12	130342580	Splice_Region	novel		0.38
UCEC	chr12	130355641	Nonsense_Mutation	novel	E460*	0.07
UCEC	chr12	130349328	Missense_Mutation	rs771090876	R275Q	0.39
UCEC	chr12	130371326	Splice_Region	novel		0.37
UCEC	chr12	130349328	Missense_Mutation	rs771090876	R275Q	0.35
UCEC	chr12	130349328	Missense_Mutation	rs771090876	R275Q	0.38
UCEC	chr12	130345760	Missense_Mutation	novel	Q66H	0.44
UCEC	chr12	130363036	Missense_Mutation	NA	R696Q	0.46	PAZ
UCEC	chr12	130367235	Silent	novel	D766D	0.43
UCEC	chr12	130371501	Missense_Mutation	novel	A830D	0.05	PAZ
UCEC	chr12	130345866	Missense_Mutation	NA	E102K	0.27
UCEC	chr12	130361564	Missense_Mutation	rs753282833	A645T	0.12	PAZ
UCEC	chr12	130371235	Missense_Mutation	NA	Y794S	0.23	PAZ
UCEC	chr12	130371668	3'UTR	novel		0.31
UCEC	chr12	130349238	Splice_Site	NA	X245_splice	0.16
UCEC	chr12	130362816	Missense_Mutation	NA	G674E	0.39	PAZ
UCEC	chr12	130346551	Silent	rs372419033	T166T	0.3
UCEC	chr12	130345872	Missense_Mutation	novel	K104E	0.24
UCEC	chr12	130354948	Missense_Mutation	novel	R411I	0.35
UCEC	chr12	130371668	3'UTR	novel		0.2
UCEC	chr12	130363106	Silent	novel	Q719Q	0.31
UCEC	chr12	130361228	Frame_Shift_Del	NA	*K573Nfs19**	0.13	PAZ
UCEC	chr12	130362991	Missense_Mutation	NA	A681V	0.48	PAZ
UCEC	chr12	130371522	Missense_Mutation	novel	K837R	0.48	PAZ
UCEC	chr12	130346513	Missense_Mutation	rs369491337	E154K	0.45
UCEC	chr12	130361590	Missense_Mutation	novel	E653D	0.3	PAZ
UCEC	chr12	130371647	3'UTR	novel		0.3
UCEC	chr12	130342579	Splice_Site	novel		0.5
UCEC	chr12	130355579	Missense_Mutation	rs552222799	R439Q	0.45
UCEC	chr12	130349328	Missense_Mutation	rs771090876	R275Q	0.46
UCEC	chr12	130361323	Missense_Mutation	novel	K603N	0.11	PAZ
UCEC	chr12	130371668	3'UTR	novel		0.43
UCEC	chr12	130361552	Missense_Mutation	NA	R641W	0.37	PAZ
UCEC	chr12	130343083	Missense_Mutation	novel	G58R	0.53
UCEC	chr12	130346498	Missense_Mutation	rs773225926	L149I	0.35
UCEC	chr12	130357018	Missense_Mutation	rs778735608	R502Q	0.36
UCEC	chr12	130371607	3'UTR	novel		0.3
UCEC	chr12	130371668	3'UTR	novel		0.34
UCEC	chr12	130349926	Missense_Mutation	NA	A335T	0.38
UCEC	chr12	130345815	Missense_Mutation	novel	D85Y	0.19
UCEC	chr12	130363051	Missense_Mutation	NA	R701H	0.23	PAZ
UCEC	chr12	130354970	Silent	novel	Q418Q	0.3
UCEC	chr12	130371668	3'UTR	novel		0.4
UCEC	chr12	130371366	Intron	novel		0.13
UCEC	chr12	130346991	Silent	rs759488848	T194T	0.34
UCEC	chr12	130355593	Missense_Mutation	novel	S444C	0.42
UCEC	chr12	130363054	Missense_Mutation	novel	D702G	0.37	PAZ
UCEC	chr12	130371229	Missense_Mutation	novel	T792I	0.17	PAZ
UCEC	chr12	130343028	Silent	novel	P39P	0.39
UCEC	chr12	130357509	Missense_Mutation	NA	Y541H	0.34
UCEC	chr12	130346991	Silent	rs759488848	T194T	0.24
UCEC	chr12	130349385	Missense_Mutation	NA	K294T	0.33
UCEC	chr12	130371814	3'UTR	novel		0.32
UCEC	chr12	130348138	Missense_Mutation	rs751181793	R230Q	0.11
UCEC	chr12	130346467	Silent	novel	P138P	0.3
UCEC	chr12	130371668	3'UTR	novel		0.29
UCEC	chr12	130371668	3'UTR	novel		0.25
UCEC	chr12	130361525	Missense_Mutation	NA	D632N	0.33	PAZ
UCEC	chr12	130361573	Missense_Mutation	novel	V648I	0.55	PAZ
UCEC	chr12	130371668	3'UTR	novel		0.38
UCEC	chr12	130371653	3'UTR	novel		0.53
UCEC	chr12	130348138	Missense_Mutation	rs751181793	R230Q	0.39
UCEC	chr12	130356954	Nonsense_Mutation	NA	E481*	0.47
UCEC	chr12	130357498	Missense_Mutation	NA	R537I	0.24
UCEC	chr12	130349385	Missense_Mutation	NA	K294T	0.2
UCEC	chr12	130371668	3'UTR	novel		0.37
UCEC	chr12	130346571	Missense_Mutation	novel	R173I	0.36
UCEC	chr12	130361214	Missense_Mutation	novel	K567T	0.04	PAZ
UCEC	chr12	130343077	Missense_Mutation	novel	A56S	0.13
UCEC	chr12	130354621	Missense_Mutation	novel	P377S	0.17
UCEC	chr12	130361219	Missense_Mutation	rs764822363	D569N	0.17	PAZ
UCEC	chr12	130361315	Missense_Mutation	novel	A601T	0.28	PAZ
UCEC	chr12	130363095	Missense_Mutation	NA	E716K	0.59	PAZ
UCEC	chr12	130346584	Missense_Mutation	NA	K177N	0.1
UCEC	chr12	130371668	3'UTR	novel		0.39
UCEC	chr12	130343077	Missense_Mutation	novel	A56T	0.39
UCEC	chr12	130349856	Splice_Region	novel	K311K	0.37
UCEC	chr12	130363069	Missense_Mutation	novel	G707D	0.41	PAZ
UCEC	chr12	130371559	Silent	novel	E849E	0.3
UCEC	chr12	130367160	Missense_Mutation	novel	K741N	0.36	PAZ
UCS	chr12	130363095	Missense_Mutation	NA	E716K	0.35	PAZ

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	DEL	0.152	0.22328
BRCA	DEL	0.162	6.3933e-07
CHOL	DEL	0.1944	0.067545
HNSC	DEL	0.0747	0.22646
LIHC	DEL	0.127	2.3723e-05
LUAD	DEL	0.155	0.0059643
LUSC	DEL	0.1198	0.038823
PAAD	DEL	0.1793	0.0030251
PRAD	DEL	0.0671	0.024258
SKCM	DEL	0.188	0.00079981
UCEC	DEL	0.0909	0.00053229
UCS	DEL	0.3393	0.033261

Survival Analysis

Cancer	P-value	Q-value
SARC	0.0022	Kaplan-Meier Survival Analysis
MESO	0.024	Kaplan-Meier Survival Analysis
ACC	0.016	Kaplan-Meier Survival Analysis
BRCA	0.023	Kaplan-Meier Survival Analysis
KIRP	0.0014	Kaplan-Meier Survival Analysis
CESC	0.046	Kaplan-Meier Survival Analysis
CHOL	0.013	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742