EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000125354 (Gene tree)
Gene ID: 23157
Gene Symbol: SEPT6
Alias: KIAA0128|SEP2|SEPT2|MGC16619|MGC20339
Full Name: septin 6
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 77,647 bases
Position: chrX:119,615,724-119,693,370
Accession: 15848
RBP type: canonical RBP
Summary: This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. One version of pediatric acute myeloid leukemia is the result of a reciprocal translocation between chromosomes 11 and X, with the breakpoint associated with the genes encoding the mixed-lineage leukemia and septin 2 proteins. This gene encodes four transcript variants encoding three distinct isoforms. An additional transcript variant has been identified, but its biological validity has not been determined. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000346169	MMR_HSR1	PF01926.23	0.00019	1	1
ENSP00000353278	MMR_HSR1	PF01926.23	0.00019	1	1
ENSP00000378108	MMR_HSR1	PF01926.23	0.00019	1	1
ENSP00000418715	MMR_HSR1	PF01926.23	0.00019	1	1
ENSP00000341524	MMR_HSR1	PF01926.23	0.00019	1	1
ENSP00000346397	MMR_HSR1	PF01926.23	0.00019	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
17229681	An RNA-binding protein, hnRNP A1, and a scaffold protein, septin 6, facilitate hepatitis C virus replication.	J Virol	2007 Apr	Kim CS	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000467310	SEPT6-207	1061	-	-	- (aa)	-	-
ENST00000354416	SEPT6-203	4652	XM_005262400	ENSP00000346397	431 (aa)	XP_005262457	B1AMS2
ENST00000481072	SEPT6-208	836	-	-	- (aa)	-	-
ENST00000360156	SEPT6-204	2609	XM_006724750	ENSP00000353278	427 (aa)	XP_006724813	Q14141
ENST00000489216	SEPT6-209	1617	-	ENSP00000418715	427 (aa)	-	Q14141
ENST00000343984	SEPT6-201	2693	XM_011531318	ENSP00000341524	434 (aa)	XP_011529620	Q14141
ENST00000394610	SEPT6-205	4694	-	ENSP00000378108	427 (aa)	-	Q14141
ENST00000460411	SEPT6-206	1393	-	ENSP00000435818	267 (aa)	-	Q14141
ENST00000354228	SEPT6-202	1576	-	ENSP00000346169	429 (aa)	-	Q14141

Gene Model

Click here to download ENSG00000125354's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa05100	Bacterial invasion of epithelial cells	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000125354's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000125354	SEPT6	100	90.398	ENSAPOG00000000347	sept6	100	90.398	Acanthochromis_polyacanthus
ENSG00000125354	SEPT6	99	90.141	ENSACIG00000013682	sept6	99	90.141	Amphilophus_citrinellus
ENSG00000125354	SEPT6	100	90.398	ENSAOCG00000011293	sept6	100	90.398	Amphiprion_ocellaris
ENSG00000125354	SEPT6	100	90.398	ENSAPEG00000005460	sept6	100	90.398	Amphiprion_percula
ENSG00000125354	SEPT6	100	89.930	ENSATEG00000018814	sept6	100	89.930	Anabas_testudineus
ENSG00000125354	SEPT6	100	99.539	ENSANAG00000033580	SEPT6	100	99.539	Aotus_nancymaae
ENSG00000125354	SEPT6	100	90.164	ENSACLG00000001734	sept6	100	90.164	Astatotilapia_calliptera
ENSG00000125354	SEPT6	100	90.210	ENSAMXG00000033660	sept6	100	90.210	Astyanax_mexicanus
ENSG00000125354	SEPT6	100	99.539	ENSCJAG00000005022	SEPT6	100	99.539	Callithrix_jacchus
ENSG00000125354	SEPT6	100	91.935	ENSCCAG00000023266	SEPT6	100	91.935	Cebus_capucinus
ENSG00000125354	SEPT6	100	100.000	ENSCATG00000036060	SEPT6	100	100.000	Cercocebus_atys
ENSG00000125354	SEPT6	100	100.000	ENSCSAG00000018351	SEPT6	100	100.000	Chlorocebus_sabaeus
ENSG00000125354	SEPT6	100	100.000	ENSCANG00000016430	SEPT6	100	100.000	Colobus_angolensis_palliatus
ENSG00000125354	SEPT6	100	98.376	ENSCGRG00001014207	Sept6	100	98.376	Cricetulus_griseus_chok1gshd
ENSG00000125354	SEPT6	99	97.387	ENSCGRG00000007825	Sept6	100	98.113	Cricetulus_griseus_crigri
ENSG00000125354	SEPT6	100	90.398	ENSCSEG00000002026	sept6	94	90.398	Cynoglossus_semilaevis
ENSG00000125354	SEPT6	100	90.398	ENSCVAG00000004959	sept6	100	90.398	Cyprinodon_variegatus
ENSG00000125354	SEPT6	100	90.632	ENSDARG00000010721	sept6	99	90.632	Danio_rerio
ENSG00000125354	SEPT6	100	90.867	ENSELUG00000020499	sept6	96	90.867	Esox_lucius
ENSG00000125354	SEPT6	100	98.157	ENSFCAG00000008744	SEPT6	100	98.157	Felis_catus
ENSG00000125354	SEPT6	100	98.157	ENSFDAG00000002473	SEPT6	100	98.157	Fukomys_damarensis
ENSG00000125354	SEPT6	100	90.398	ENSFHEG00000017987	sept6	100	90.398	Fundulus_heteroclitus
ENSG00000125354	SEPT6	100	89.862	ENSGMOG00000001671	sept6	100	89.862	Gadus_morhua
ENSG00000125354	SEPT6	100	90.164	ENSGAFG00000000922	sept6	100	90.164	Gambusia_affinis
ENSG00000125354	SEPT6	100	90.092	ENSGACG00000017441	sept6	100	90.092	Gasterosteus_aculeatus
ENSG00000125354	SEPT6	100	100.000	ENSGGOG00000009733	SEPT6	100	100.000	Gorilla_gorilla
ENSG00000125354	SEPT6	100	90.164	ENSHBUG00000017506	sept6	100	90.164	Haplochromis_burtoni
ENSG00000125354	SEPT6	100	90.443	ENSHCOG00000017047	sept6	100	90.443	Hippocampus_comes
ENSG00000125354	SEPT6	100	90.443	ENSIPUG00000019317	sept6	85	90.443	Ictalurus_punctatus
ENSG00000125354	SEPT6	100	97.696	ENSJJAG00000020412	Sept6	100	97.696	Jaculus_jaculus
ENSG00000125354	SEPT6	100	90.210	ENSKMAG00000020207	sept6	100	90.210	Kryptolebias_marmoratus
ENSG00000125354	SEPT6	100	90.443	ENSLBEG00000028683	sept6	95	90.443	Labrus_bergylta
ENSG00000125354	SEPT6	100	91.101	ENSLOCG00000015233	sept6	100	91.771	Lepisosteus_oculatus
ENSG00000125354	SEPT6	100	100.000	ENSMFAG00000003084	SEPT6	100	100.000	Macaca_fascicularis
ENSG00000125354	SEPT6	100	100.000	ENSMMUG00000017669	SEPT6	100	100.000	Macaca_mulatta
ENSG00000125354	SEPT6	100	100.000	ENSMNEG00000026932	SEPT6	100	100.000	Macaca_nemestrina
ENSG00000125354	SEPT6	100	100.000	ENSMLEG00000030428	SEPT6	100	100.000	Mandrillus_leucophaeus
ENSG00000125354	SEPT6	100	90.164	ENSMAMG00000019988	sept6	100	90.164	Mastacembelus_armatus
ENSG00000125354	SEPT6	100	90.164	ENSMZEG00005007935	sept6	89	90.164	Maylandia_zebra
ENSG00000125354	SEPT6	100	98.157	ENSMAUG00000018038	Sept6	100	98.157	Mesocricetus_auratus
ENSG00000125354	SEPT6	98	98.571	ENSMOCG00000000500	Sept6	99	98.798	Microtus_ochrogaster
ENSG00000125354	SEPT6	97	91.063	ENSMMOG00000004176	sept6	97	91.063	Mola_mola
ENSG00000125354	SEPT6	100	89.631	ENSMALG00000007921	sept6	100	89.631	Monopterus_albus
ENSG00000125354	SEPT6	100	96.503	MGP_CAROLIEiJ_G0032996	Sept6	100	96.503	Mus_caroli
ENSG00000125354	SEPT6	100	96.270	ENSMUSG00000050379	Sept6	100	96.270	Mus_musculus
ENSG00000125354	SEPT6	99	94.737	MGP_PahariEiJ_G0031540	-	71	95.817	Mus_pahari
ENSG00000125354	SEPT6	100	96.503	MGP_SPRETEiJ_G0034149	Sept6	100	96.503	Mus_spretus
ENSG00000125354	SEPT6	97	97.115	ENSMLUG00000005623	SEPT6	95	97.115	Myotis_lucifugus
ENSG00000125354	SEPT6	100	96.544	ENSNGAG00000010702	Sept6	100	96.544	Nannospalax_galili
ENSG00000125354	SEPT6	99	82.864	ENSNBRG00000011675	sept6	99	82.864	Neolamprologus_brichardi
ENSG00000125354	SEPT6	100	100.000	ENSNLEG00000014873	SEPT6	100	100.000	Nomascus_leucogenys
ENSG00000125354	SEPT6	100	90.398	ENSONIG00000002528	sept6	99	90.398	Oreochromis_niloticus
ENSG00000125354	SEPT6	100	89.930	ENSORLG00000000997	sept6	100	90.750	Oryzias_latipes
ENSG00000125354	SEPT6	100	89.930	ENSORLG00020003886	sept6	100	89.930	Oryzias_latipes_hni
ENSG00000125354	SEPT6	100	89.930	ENSORLG00015013025	sept6	100	89.930	Oryzias_latipes_hsok
ENSG00000125354	SEPT6	100	88.759	ENSOMEG00000014650	sept6	100	88.759	Oryzias_melastigma
ENSG00000125354	SEPT6	100	100.000	ENSPPAG00000040865	SEPT6	100	100.000	Pan_paniscus
ENSG00000125354	SEPT6	100	97.926	ENSPPRG00000023588	SEPT6	100	97.926	Panthera_pardus
ENSG00000125354	SEPT6	93	97.177	ENSPTIG00000015338	SEPT6	99	84.428	Panthera_tigris_altaica
ENSG00000125354	SEPT6	100	99.770	ENSPTRG00000022227	SEPT6	100	99.770	Pan_troglodytes
ENSG00000125354	SEPT6	100	100.000	ENSPANG00000000899	SEPT6	100	100.000	Papio_anubis
ENSG00000125354	SEPT6	100	85.315	ENSPKIG00000019114	sept6	100	85.315	Paramormyrops_kingsleyae
ENSG00000125354	SEPT6	99	91.549	ENSPKIG00000013948	SEPT6	100	92.250	Paramormyrops_kingsleyae
ENSG00000125354	SEPT6	99	88.498	ENSPMGG00000012133	sept6	100	88.498	Periophthalmus_magnuspinnatus
ENSG00000125354	SEPT6	100	98.387	ENSPEMG00000016450	Sept6	100	98.387	Peromyscus_maniculatus_bairdii
ENSG00000125354	SEPT6	100	90.783	ENSPCIG00000028910	SEPT6	100	90.783	Phascolarctos_cinereus
ENSG00000125354	SEPT6	98	90.736	ENSPFOG00000024721	sept6	97	90.736	Poecilia_formosa
ENSG00000125354	SEPT6	84	88.000	ENSPLAG00000005147	sept6	93	88.000	Poecilia_latipinna
ENSG00000125354	SEPT6	100	90.398	ENSPLAG00000019878	sept6	100	90.398	Poecilia_latipinna
ENSG00000125354	SEPT6	100	90.398	ENSPMEG00000023470	sept6	100	90.398	Poecilia_mexicana
ENSG00000125354	SEPT6	100	89.930	ENSPREG00000012310	sept6	100	89.930	Poecilia_reticulata
ENSG00000125354	SEPT6	100	98.126	ENSPPYG00000020673	SEPT6	100	98.126	Pongo_abelii
ENSG00000125354	SEPT6	100	90.210	ENSPNYG00000009709	sept6	100	91.000	Pundamilia_nyererei
ENSG00000125354	SEPT6	100	90.909	ENSPNAG00000021638	sept6	100	90.909	Pygocentrus_nattereri
ENSG00000125354	SEPT6	100	100.000	ENSRBIG00000044672	SEPT6	100	100.000	Rhinopithecus_bieti
ENSG00000125354	SEPT6	100	100.000	ENSRROG00000038667	SEPT6	100	100.000	Rhinopithecus_roxellana
ENSG00000125354	SEPT6	100	99.309	ENSSBOG00000024143	SEPT6	100	99.309	Saimiri_boliviensis_boliviensis
ENSG00000125354	SEPT6	99	90.588	ENSSHAG00000007460	SEPT6	98	90.588	Sarcophilus_harrisii
ENSG00000125354	SEPT6	100	90.443	ENSSFOG00015010832	SEPT6	100	90.443	Scleropages_formosus
ENSG00000125354	SEPT6	100	88.759	ENSSFOG00015005477	sept6	100	88.759	Scleropages_formosus
ENSG00000125354	SEPT6	100	90.092	ENSSMAG00000012785	sept6	100	90.092	Scophthalmus_maximus
ENSG00000125354	SEPT6	100	90.398	ENSSDUG00000005575	sept6	100	90.398	Seriola_dumerili
ENSG00000125354	SEPT6	100	90.443	ENSSLDG00000003277	sept6	100	90.443	Seriola_lalandi_dorsalis
ENSG00000125354	SEPT6	100	90.398	ENSSPAG00000010108	sept6	100	90.398	Stegastes_partitus
ENSG00000125354	SEPT6	100	89.696	ENSTRUG00000010830	sept6	100	90.796	Takifugu_rubripes
ENSG00000125354	SEPT6	100	88.290	ENSTNIG00000015761	sept6	100	88.167	Tetraodon_nigroviridis
ENSG00000125354	SEPT6	90	84.583	ENSXCOG00000016712	sept6	89	84.583	Xiphophorus_couchianus
ENSG00000125354	SEPT6	100	90.443	ENSXMAG00000013699	sept6	100	90.443	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000281	mitotic cytokinesis	11809673.	TAS	Process
GO:0000777	condensed chromosome kinetochore	-	IEA	Component
GO:0003924	GTPase activity	21873635.	IBA	Function
GO:0005515	protein binding	16189514.17229681.17637674.17803907.18047794.18330356.24633326.25416956.25588830.25775403.26871637.30021884.	IPI	Function
GO:0005525	GTP binding	11809673.	TAS	Function
GO:0005819	spindle	-	IEA	Component
GO:0005940	septin ring	21873635.	IBA	Component
GO:0007283	spermatogenesis	-	IEA	Process
GO:0008021	synaptic vesicle	-	IEA	Component
GO:0015630	microtubule cytoskeleton	21873635.	IBA	Component
GO:0016032	viral process	-	IEA	Process
GO:0030154	cell differentiation	-	IEA	Process
GO:0030496	midbody	-	IEA	Component
GO:0031105	septin complex	21873635.	IBA	Component
GO:0031105	septin complex	25588830.	IDA	Component
GO:0032154	cleavage furrow	-	IEA	Component
GO:0032173	septin collar	-	IEA	Component
GO:0043679	axon terminus	-	IEA	Component
GO:0060090	molecular adaptor activity	21873635.	IBA	Function
GO:0060271	cilium assembly	21873635.	IBA	Process
GO:0061640	cytoskeleton-dependent cytokinesis	21873635.	IBA	Process
GO:0097227	sperm annulus	25588830.	IDA	Component

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
25519054	MiR-223-3p targeting SEPT6 promotes the biological behavior of prostate cancer.	Sci Rep	2014 Dec 18	Wei Y	doi: 10.1038/srep07546.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chrX	119640752	Missense_Mutation	novel	E243Q	0.78
ACC	chrX	119629370	Missense_Mutation	novel	G410S	0.16
BLCA	chrX	119618738	3'UTR	novel		0.08
BLCA	chrX	119652950	Missense_Mutation	NA	H144Q	0.4
BRCA	chrX	119618632	3'UTR	novel		0.25
BRCA	chrX	119693174	5'UTR	novel		0.09
BRCA	chrX	119675655	Missense_Mutation	rs756379839	R15Q	0.27
BRCA	chrX	119618767	Missense_Mutation	novel	E434K	0.54
BRCA	chrX	119675576	Silent	novel	F41F	0.14
BRCA	chrX	119618763	Nonstop_Mutation	novel	435Sext22	0.1
BRCA	chrX	119646766	Intron	NA		0.24
BRCA	chrX	119637043	Missense_Mutation	NA	D314H	0.3
BRCA	chrX	119616613	3'Flank	novel		0.36
BRCA	chrX	119618544	3'UTR	novel		0.44
CESC	chrX	119616479	3'Flank	novel		0.21
CESC	chrX	119629487	Missense_Mutation	novel	L371M	0.08
CESC	chrX	119629461	Silent	NA	K379K	0.23
CESC	chrX	119629396	Missense_Mutation	rs770681536	T401M	0.14
CESC	chrX	119663489	Missense_Mutation	novel	E112K	0.08	MMR_HSR1
CESC	chrX	119637071	Silent	novel	E304E	0.08
CESC	chrX	119619995	Intron	novel		0.34
CESC	chrX	119629284	Intron	NA		0.33
CESC	chrX	119618849	Intron	novel		0.26
CESC	chrX	119620025	Intron	novel		0.13
CHOL	chrX	119616718	3'Flank	novel		0.06
CHOL	chrX	119616719	3'Flank	novel		0.04
CHOL	chrX	119618544	3'UTR	novel		0.85
COAD	chrX	119663622	Silent	NA	F67F	0.22
COAD	chrX	119675596	Nonsense_Mutation	novel	K35*	0.16
COAD	chrX	119675662	Missense_Mutation	novel	G13S	0.08
COAD	chrX	119693140	5'UTR	novel		0.39
COAD	chrX	119616735	3'Flank	NA		0.24
COAD	chrX	119618544	3'UTR	novel		0.31
COAD	chrX	119650032	Missense_Mutation	novel	I199V	0.05
COAD	chrX	119618659	3'UTR	novel		0.87
COAD	chrX	119620050	Intron	NA		0.16
COAD	chrX	119650058	Missense_Mutation	NA	S190L	0.17
COAD	chrX	119637145	Missense_Mutation	rs4335271	R280W	0.28
COAD	chrX	119652909	Missense_Mutation	rs145877420	T158M	0.06
COAD	chrX	119663622	Silent	NA	F67F	0.41
COAD	chrX	119633435	Frame_Shift_Del	novel	*E339Kfs4**	0.24
COAD	chrX	119637024	Splice_Region	novel		0.2
COAD	chrX	119653039	Frame_Shift_Ins	novel	*Y115Nfs33**	0.06	MMR_HSR1
DLBC	chrX	119663675	Nonsense_Mutation	novel	E50*	0.65	MMR_HSR1
ESCA	chrX	119633417	Missense_Mutation	novel	Q344H	0.26
GBM	chrX	119633478	Missense_Mutation	novel	Y324S	0.1
GBM	chrX	119616573	3'Flank	novel		0.45
GBM	chrX	119640718	Missense_Mutation	novel	R254Q	0.25
HNSC	chrX	119637081	Missense_Mutation	novel	C301S	0.28
HNSC	chrX	119629410	Silent	novel	F396F	0.41
HNSC	chrX	119637141	Missense_Mutation	novel	V281A	0.37
HNSC	chrX	119619988	Intron	novel		0.18
HNSC	chrX	119619984	Intron	novel		0.44
HNSC	chrX	119619985	Intron	novel		0.44
HNSC	chrX	119653041	Splice_Site	novel	X114_splice	0.16
HNSC	chrX	119663616	Silent	novel	G69G	0.21
KIRC	chrX	119646739	Intron	NA		0.22
KIRP	chrX	119675599	Missense_Mutation	novel	N34D	0.28
KIRP	chrX	119663632	Missense_Mutation	NA	N64I	0.11	MMR_HSR1
LAML	chrX	119633431	Frame_Shift_Del	novel	*E340Rfs3**	0.11
LGG	chrX	119640720	Silent	rs143382025	A253A	0.11
LGG	chrX	119640763	Missense_Mutation	novel	G239D	0.18
LIHC	chrX	119693088	Missense_Mutation	NA	I6M	0.59
LIHC	chrX	119616584	3'Flank	novel		0.34
LIHC	chrX	119633470	Nonsense_Mutation	novel	K327*	0.05
LIHC	chrX	119693247	5'UTR	novel		0.17
LIHC	chrX	119618532	3'UTR	novel		0.25
LUAD	chrX	119652901	Missense_Mutation	NA	S161T	0.06
LUAD	chrX	119620017	Intron	novel		0.33
LUAD	chrX	119652893	Missense_Mutation	novel	K163N	0.23
LUAD	chrX	119618836	Intron	novel		0.18
LUAD	chrX	119618837	Intron	novel		0.16
LUAD	chrX	119618790	Splice_Region	novel		0.15
LUAD	chrX	119629170	Intron	novel		0.28
LUAD	chrX	119629490	Missense_Mutation	NA	R370S	0.23
LUAD	chrX	119633476	Missense_Mutation	NA	E325K	0.34
LUAD	chrX	119625338	Intron	novel		0.35
LUAD	chrX	119637073	Nonsense_Mutation	NA	E304*	0.11
LUAD	chrX	119637056	Silent	NA	K309K	0.13
LUAD	chrX	119650024	Silent	NA	I201I	0.14
LUAD	chrX	119640777	Silent	novel	P234P	0.27
LUAD	chrX	119637099	Missense_Mutation	novel	Y295S	0.26
LUAD	chrX	119629285	Intron	novel		0.44
LUAD	chrX	119663548	Missense_Mutation	NA	N92S	0.26	MMR_HSR1
LUAD	chrX	119663639	Silent	NA	L62L	0.11
LUAD	chrX	119637185	Missense_Mutation	novel	E266D	0.28
LUAD	chrX	119637142	Missense_Mutation	NA	V281F	0.44
LUSC	chrX	119629385	Missense_Mutation	NA	L405M	0.46
LUSC	chrX	119640780	Silent	novel	L233L	0.37
LUSC	chrX	119619984	Intron	novel		0.09
LUSC	chrX	119637119	Missense_Mutation	novel	E288D	0.1
LUSC	chrX	119663579	Missense_Mutation	novel	Q82E	0.56	MMR_HSR1
OV	chrX	119616590	3'Flank	novel		0.13
OV	chrX	119618756	3'UTR	novel		0.13
OV	chrX	119675561	Silent	novel	L46L	0.11
OV	chrX	119629486	Missense_Mutation	novel	L371R	0.04
OV	chrX	119618745	3'UTR	novel		0.04
PRAD	chrX	119650018	Silent	rs143380835	S203S	0.1
READ	chrX	119637085	Missense_Mutation	rs202165661	R300C	0.18
READ	chrX	119616736	3'Flank	novel		0.12
READ	chrX	119618441	3'UTR	novel		1
READ	chrX	119653005	Missense_Mutation	NA	F126C	0.78
SARC	chrX	119616414	3'Flank	novel		0.08
SKCM	chrX	119618709	3'UTR	novel		0.69
SKCM	chrX	119652973	Nonsense_Mutation	NA	R137*	0.7
SKCM	chrX	119653004	Silent	NA	F126F	0.64
SKCM	chrX	119616635	3'Flank	novel		0.47
SKCM	chrX	119663564	Missense_Mutation	rs767701064	D87N	0.38	MMR_HSR1
SKCM	chrX	119650017	Missense_Mutation	NA	E204K	0.32
SKCM	chrX	119650057	Silent	rs780576827	S190S	0.95
SKCM	chrX	119618757	3'UTR	novel		0.9
SKCM	chrX	119650017	Missense_Mutation	NA	E204K	0.41
SKCM	chrX	119650030	Silent	NA	I199I	0.32
SKCM	chrX	119633465	Silent	NA	R328R	0.39
SKCM	chrX	119616635	3'Flank	novel		1
SKCM	chrX	119620042	Intron	novel		0.09
SKCM	chrX	119637114	Missense_Mutation	NA	T290I	0.41
SKCM	chrX	119629502	Missense_Mutation	rs767841172	E366K	0.41
STAD	chrX	119633493	Splice_Site	novel	X319_splice	0.2
STAD	chrX	119629409	Nonsense_Mutation	novel	K397*	0.11
STAD	chrX	119618659	3'UTR	novel		0.28
STAD	chrX	119618659	3'UTR	novel		0.65
STAD	chrX	119663546	Missense_Mutation	NA	V93M	0.08	MMR_HSR1
STAD	chrX	119633435	Frame_Shift_Del	novel	*E339Kfs4**	0.25
STAD	chrX	119633410	Missense_Mutation	NA	V347I	0.42
STAD	chrX	119633489	Silent	NA	L320L	0.88
STAD	chrX	119619983	Intron	novel		0.55
STAD	chrX	119629490	Missense_Mutation	rs150468538	R370C	0.32
TGCT	chrX	119640717	Silent	novel	R254R	0.08
THCA	chrX	119618809	Intron	novel		0.2
THCA	chrX	119637091	Missense_Mutation	NA	Y298D	0.25
THCA	chrX	119663496	Silent	NA	I109I	0.06
UCEC	chrX	119618522	3'UTR	novel		0.33
UCEC	chrX	119618713	3'UTR	novel		0.33
UCEC	chrX	119663530	Missense_Mutation	rs774447993	T98M	0.35	MMR_HSR1
UCEC	chrX	119652932	Silent	novel	V150V	0.04
UCEC	chrX	119663547	Silent	rs201551217	N92N	0.35
UCEC	chrX	119653004	Silent	NA	F126F	0.36
UCEC	chrX	119616734	3'Flank	novel		0.4
UCEC	chrX	119652972	Missense_Mutation	NA	R137Q	0.14
UCEC	chrX	119650081	Silent	novel	I182I	0.36
UCEC	chrX	119637145	Missense_Mutation	rs4335271	R280W	0.29
UCEC	chrX	119663593	Missense_Mutation	rs758319667	P77L	0.44	MMR_HSR1
UCEC	chrX	119652915	Missense_Mutation	novel	A156V	0.41
UCEC	chrX	119629482	Silent	NA	K372K	0.45
UCEC	chrX	119653004	Silent	NA	F126F	0.28
UCEC	chrX	119629158	Intron	novel		0.19
UCEC	chrX	119663551	Missense_Mutation	novel	S91N	0.2	MMR_HSR1
UCEC	chrX	119629396	Missense_Mutation	rs770681536	T401M	0.08
UCEC	chrX	119616311	3'Flank	novel		0.33
UCEC	chrX	119625348	Intron	novel		0.11
UCEC	chrX	119629294	Intron	novel		0.47
UCEC	chrX	119618595	3'UTR	novel		0.31
UCEC	chrX	119616319	3'Flank	novel		0.5
UCEC	chrX	119649936	Splice_Site	NA	X230_splice	0.11
UCEC	chrX	119650093	Silent	novel	N178N	0.37
UCEC	chrX	119663547	Silent	rs201551217	N92N	0.39
UCEC	chrX	119616420	3'Flank	novel		0.27
UCEC	chrX	119637155	Missense_Mutation	novel	E276D	0.35
UCEC	chrX	119640733	Missense_Mutation	novel	K249T	0.3
UCEC	chrX	119629165	Intron	novel		0.23
UCEC	chrX	119650057	Silent	rs780576827	S190S	0.44
UCEC	chrX	119637188	Silent	rs760630055	N265N	0.58
UCEC	chrX	119637056	Missense_Mutation	novel	K309N	0.38
UCEC	chrX	119650068	Missense_Mutation	novel	D187Y	0.43
UCEC	chrX	119653004	Silent	NA	F126F	0.64
UCEC	chrX	119640692	Missense_Mutation	novel	V263F	0.46
UCEC	chrX	119618544	3'UTR	novel		0.45
UCEC	chrX	119637146	Silent	novel	I279I	0.44
UCEC	chrX	119619975	Intron	novel		0.12
UCEC	chrX	119633362	Nonsense_Mutation	novel	E363*	0.18
UCEC	chrX	119653016	Silent	rs771811719	I122I	0.16
UCEC	chrX	119616384	3'Flank	novel		0.42
UCEC	chrX	119637155	Silent	novel	E276E	0.32
UCEC	chrX	119616735	3'Flank	NA		0.41
UCEC	chrX	119675574	Missense_Mutation	novel	C42Y	0.11
UCEC	chrX	119640709	Missense_Mutation	novel	P257H	0.41
UCEC	chrX	119675605	Silent	novel	L32L	0.22
UCEC	chrX	119693147	5'UTR	novel		0.4
UCEC	chrX	119620014	Intron	novel		0.09
UCEC	chrX	119619993	Intron	novel		0.12
UCEC	chrX	119629343	Silent	novel	L419L	0.28
UCEC	chrX	119616509	3'Flank	novel		0.06
UCEC	chrX	119619913	Intron	novel		0.29
UCEC	chrX	119637087	Missense_Mutation	NA	R299H	0.28
UCEC	chrX	119663548	Missense_Mutation	NA	N92S	0.31	MMR_HSR1
UCEC	chrX	119675662	Missense_Mutation	NA	G13C	0.4
UCEC	chrX	119633368	Nonsense_Mutation	NA	E361*	0.21
UCEC	chrX	119693278	5'UTR	novel		0.6
UCEC	chrX	119650064	Missense_Mutation	NA	A188V	0.42
UCEC	chrX	119652920	Missense_Mutation	NA	F154L	0.45
UCEC	chrX	119629323	Missense_Mutation	NA	K425N	0.22
UCEC	chrX	119652878	Silent	rs774606542	V168V	0.07
UCEC	chrX	119616319	3'Flank	novel		0.28
UCEC	chrX	119652893	Silent	novel	K163K	0.36
UCEC	chrX	119633363	Missense_Mutation	novel	K362N	0.38
UCEC	chrX	119652856	Missense_Mutation	novel	K176E	0.47
UCEC	chrX	119616735	3'Flank	NA		0.22
UCEC	chrX	119619026	Intron	novel		0.32
UCEC	chrX	119629389	Silent	novel	A403A	0.47
UCS	chrX	119629390	Missense_Mutation	novel	A403V	0.35
UVM	chrX	119640778	Missense_Mutation	rs764588243	P234L	0.35

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.0778	0.032456
BLCA	DEL	0.1029	2.0711e-36
BRCA	DEL	0.0806	2.4898e-11
CESC	DEL	0.0814	3.4658e-41
HNSC	DEL	0.046	1.278e-25
KIRC	AMP	0.0265	0.12739
KIRC	DEL	0.0436	5.6049e-16
KIRP	DEL	0.0347	5.174e-05
LGG	DEL	0.0468	1.4015e-20
LIHC	DEL	0.0622	0.0022356
LUSC	DEL	0.0679	1.3904e-19
OV	DEL	0.2573	7.0161e-09
PAAD	AMP	0.0543	0.1091
PAAD	DEL	0.0217	0.2014
SARC	DEL	0.3502	7.1647e-24
SKCM	DEL	0.0845	3.1096e-12
TGCT	DEL	0.0667	0.08422
THCA	DEL	0	0.21991
UCEC	DEL	0.0557	0.00045104
UVM	DEL	0.025	0.024639

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0031	Kaplan-Meier Survival Analysis
MESO	0.0043	Kaplan-Meier Survival Analysis
SKCM	0.0032	Kaplan-Meier Survival Analysis
BRCA	0.041	Kaplan-Meier Survival Analysis
CESC	0.009	Kaplan-Meier Survival Analysis
GBM	0.011	Kaplan-Meier Survival Analysis
LGG	0.00014	Kaplan-Meier Survival Analysis
LUAD	0.036	Kaplan-Meier Survival Analysis
UVM	0.032	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742