EuRBPDB

Description

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000125651 (Gene tree)
Gene ID: 2962
Gene Symbol: GTF2F1
Alias: TFIIF|BTF4|RAP74|TF2F1
Full Name: general transcription factor IIF subunit 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 14,413 bases
Position: chr19:6,379,569-6,393,981
Accession: 4652
RBP type: non-canonical RBP
Summary: (General Transcription Factor IIF Subunit 1) is a Protein Coding gene. Among its related pathways are Chromatin Regulation / Acetylation and Tat-mediated elongation of the HIV-1 transcript. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Protein-RNA interaction（RNA-Binding Site）

Click here to download all RNA binding sites

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
1734284	A cDNA encoding RAP74, a general initiation factor for transcription by RNA polymerase II.	Nature	1992 Jan 30	Finkelstein A	-
16934821	Promoter trapping of c-jun promoter-binding transcription factors.	J Chromatogr A	2006 Nov 10	Jiang D	-
22343046	Activator-mediator binding stabilizes RNA polymerase II orientation within the human mediator-RNA polymerase II-TFIIF assembly.	J Mol Biol	2012 Apr 13	Bernecky C	doi: 10.1016/j.jmb.2012.02.014
1429731	The carboxyl terminus of RAP30 is similar in sequence to region 4 of bacterial sigma factors and is required for function.	J Biol Chem	1992 Nov 25	Garrett KP	-
9164864	TFIIF, a basal eukaryotic transcription factor, is a substrate for poly(ADP-ribosyl)ation.	Biochem J	1997 May 15	Rawling JM	-
8515820	Functional dissection of TFIIB domains required for TFIIB-TFIID-promoter complex formation and basal transcription activity.	Nature	1993 Jun 24	Hisatake K	-
8319911	Identification of a minimal set of proteins that is sufficient for accurate initiation of transcription by RNA polymerase II.	Genes Dev	1993 Jul	Tyree CM	-
7948016	Enhancement of bacterial transcription initiation in vitro by the 74 kDa subunit of human general transcription factor IIF (RAP74).	Biochim Biophys Acta	1994 Nov 22	Chibazakura T	-
7753175	Control of transcription by Kruppel through interactions with TFIIB and TFIIE beta.	Nature	1995 May 11	Sauer F	-
7590250	Human TAFII250 interacts with RAP74: implications for RNA polymerase II initiation.	Genes Dev	1995 Nov 15	Ruppert S	-
10872452	Transcription elongation and human disease.	Annu Rev Biochem	1999	Conaway JW	-
14664704	Role of conserved hydrophobic amino acids in androgen receptor AF-1 function.	J Mol Endocrinol	2003 Dec	Betney R	-
21468301	Molecular architecture of the human Mediator-RNA polymerase II-TFIIF assembly.	PLoS Biol	2011 Mar	Bernecky C	doi: 10.1371/journal.pbio.1000603
20797630	RNA polymerase I contains a TFIIF-related DNA-binding subcomplex.	Mol Cell	2010 Aug 27	Geiger SR	doi: 10.1016/j.molcel.2010.07.028.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000594965	GTF2F1-204	762	-	-	- (aa)	-	-
ENST00000593678	GTF2F1-202	1705	-	ENSP00000469091	433 (aa)	-	M0QXD6
ENST00000394456	GTF2F1-201	2731	XM_024451475	ENSP00000377969	517 (aa)	XP_024307243	P35269
ENST00000594213	GTF2F1-203	1002	-	-	- (aa)	-	-
ENST00000598607	GTF2F1-206	568	-	ENSP00000471542	127 (aa)	-	M0R0Z3
ENST00000595047	GTF2F1-205	1382	-	ENSP00000471403	381 (aa)	-	M0R0R9

Gene Model

Click here to download ENSG00000125651's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03022	Basal transcription factors	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000125651's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000125651	GTF2F1	100	100.000	ENSMUSG00000002658	Gtf2f1	100	91.489	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000398	mRNA splicing, via spliceosome	-	TAS	Process
GO:0003677	DNA binding	-	IEA	Function
GO:0003713	transcription coactivator activity	7854423.	TAS	Function
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005515	protein binding	7590250.7667268.7854423.8662660.9765293.11183778.12721286.12737519.12931194.	IPI	Function
GO:0005634	nucleus	-	IDA	Component
GO:0005634	nucleus	15723517.	IMP	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005669	transcription factor TFIID complex	27193682.	IDA	Component
GO:0005674	transcription factor TFIIF complex	1734283.	TAS	Component
GO:0006366	transcription by RNA polymerase II	-	TAS	Process
GO:0006367	transcription initiation from RNA polymerase II promoter	-	TAS	Process
GO:0006368	transcription elongation from RNA polymerase II promoter	-	TAS	Process
GO:0006370	7-methylguanosine mRNA capping	-	TAS	Process
GO:0008134	transcription factor binding	8625415.	IPI	Function
GO:0008543	fibroblast growth factor receptor signaling pathway	-	TAS	Process
GO:0009615	response to virus	16548883.	IEP	Process
GO:0016070	RNA metabolic process	-	TAS	Process
GO:0016251	RNA polymerase II general transcription initiation factor activity	27193682.	IDA	Function
GO:0019211	phosphatase activator activity	12721286.	IDA	Function
GO:0019903	protein phosphatase binding	12732728.	IPI	Function
GO:0019904	protein domain specific binding	15723517.	IPI	Function
GO:0030054	cell junction	-	IDA	Component
GO:0032091	negative regulation of protein binding	8662660.	IMP	Process
GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter	-	IEA	Process
GO:0032991	protein-containing complex	12732728.	IMP	Component
GO:0042795	snRNA transcription by RNA polymerase II	-	TAS	Process
GO:0043085	positive regulation of catalytic activity	-	IEA	Process
GO:0043231	intracellular membrane-bounded organelle	-	IDA	Component
GO:0045944	positive regulation of transcription by RNA polymerase II	8662660.	IMP	Process
GO:0050434	positive regulation of viral transcription	-	TAS	Process
GO:1990841	promoter-specific chromatin binding	24441171.	IDA	Function