EuRBPDB

Description

Ensembl ID: ENSG00000125821 (Gene tree)
Gene ID: 92675
Gene Symbol: DTD1
Alias: DUEB|MGC119131|MGC41905|bA379J5.3|bA555E18.1|pqn-68|C20orf88|HARS2
Full Name: D-aminoacyl-tRNA deacylase 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 178,752 bases
Position: chr20:18,587,893-18,766,644
Accession: 16219
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is similar in sequence to histidyl-tRNA synthetase, which hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). The encoded protein binds the DNA unwinding element and plays a role in the initiation of DNA replication. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000494921	DTD1-202	2890	-	ENSP00000495845	213 (aa)	-	A0A2R8Y6X2
ENST00000377452	DTD1-201	1387	XM_005260872	ENSP00000366672	209 (aa)	XP_005260929	Q8TEA8
ENST00000647441	DTD1-203	4112	-	ENSP00000493969	127 (aa)	-	A0A2R8YCT7

Gene Model

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000125821	Blood Glucose	8.5860000E-005	-
ENSG00000125821	Platelet Function Tests	1.0640600E-005	-
ENSG00000125821	Platelet Function Tests	1.1356800E-005	-
ENSG00000125821	Platelet Function Tests	1.1669500E-005	-
ENSG00000125821	Platelet Function Tests	8.2951645E-006	-
ENSG00000125821	Sleep	5E-6	27126917

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000125821	rs150097070	20	18680023	G	Night sleep phenotypes	27126917	[0.076-0.19] unit increase	0.1333	EFO_0005272
ENSG00000125821	rs148286224	20	18659884	?	DNA methylation variation (age effect)	30348214			GO_0006306
ENSG00000125821	rs1998122	20	18727895	A	Worry	29942085	[0.0092-0.0188] unit decrease	0.01403	EFO_0005230

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000125821	DTD1	100	95.215	ENSMUSG00000027430	Dtd1	100	95.215	Mus_musculus
ENSG00000125821	DTD1	100	45.312	YDL219W	DTD1	99	47.297	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000049	tRNA binding	-	IEA	Function
GO:0002161	aminoacyl-tRNA editing activity	21873635.	IBA	Function
GO:0003677	DNA binding	-	IEA	Function
GO:0005730	nucleolus	-	IDA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0006260	DNA replication	-	IEA	Process
GO:0006399	tRNA metabolic process	21873635.	IBA	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0051500	D-tyrosyl-tRNA(Tyr) deacylase activity	21873635.	IBA	Function
GO:0106074	aminoacyl-tRNA metabolism involved in translational fidelity	-	IEA	Process