EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000125901 (Gene tree)
Gene ID: 64949
Gene Symbol: MRPS26
Alias: MRP-S13|MRP-S26|RPMS13|dJ534B8.3|C20orf193
Full Name: mitochondrial ribosomal protein S26
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 2,310 bases
Position: chr20:3,045,945-3,048,254
Accession: 14045
RBP type: canonical RBP
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. This gene lies adjacent to and downstream of the gonadotropin-releasing hormone precursor gene. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000369682	MRP-S26	PF14943.6	5.1e-49	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000380325	MRPS26-201	1127	-	ENSP00000369682	205 (aa)	-	Q9BYN8

Gene Model

Click here to download ENSG00000125901's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000125901's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000125901	MRPS26	90	53.226	ENSAPOG00000005118	mrps26	89	50.811	Acanthochromis_polyacanthus
ENSG00000125901	MRPS26	100	76.812	ENSAMEG00000011078	MRPS26	100	76.812	Ailuropoda_melanoleuca
ENSG00000125901	MRPS26	90	52.688	ENSACIG00000004862	mrps26	89	50.811	Amphilophus_citrinellus
ENSG00000125901	MRPS26	90	51.075	ENSAOCG00000020131	mrps26	89	49.730	Amphiprion_ocellaris
ENSG00000125901	MRPS26	90	52.688	ENSAPEG00000005553	mrps26	89	49.730	Amphiprion_percula
ENSG00000125901	MRPS26	90	48.108	ENSATEG00000018841	mrps26	89	48.108	Anabas_testudineus
ENSG00000125901	MRPS26	79	84.472	ENSANAG00000032079	-	82	84.472	Aotus_nancymaae
ENSG00000125901	MRPS26	100	63.902	ENSANAG00000033577	-	100	63.902	Aotus_nancymaae
ENSG00000125901	MRPS26	90	51.351	ENSACLG00000014099	mrps26	89	50.270	Astatotilapia_calliptera
ENSG00000125901	MRPS26	88	50.829	ENSAMXG00000010899	mrps26	87	48.370	Astyanax_mexicanus
ENSG00000125901	MRPS26	100	78.049	ENSBTAG00000000825	MRPS26	100	78.049	Bos_taurus
ENSG00000125901	MRPS26	100	84.878	ENSCJAG00000021090	MRPS26	100	84.878	Callithrix_jacchus
ENSG00000125901	MRPS26	100	75.728	ENSCAFG00000006438	MRPS26	100	75.728	Canis_familiaris
ENSG00000125901	MRPS26	79	73.913	ENSCAFG00020003198	MRPS26	84	73.913	Canis_lupus_dingo
ENSG00000125901	MRPS26	100	78.049	ENSCHIG00000001147	-	100	78.049	Capra_hircus
ENSG00000125901	MRPS26	97	60.606	ENSCHIG00000022599	-	89	60.606	Capra_hircus
ENSG00000125901	MRPS26	77	86.076	ENSTSYG00000028150	MRPS26	77	86.076	Carlito_syrichta
ENSG00000125901	MRPS26	100	74.634	ENSCPOG00000037912	MRPS26	83	74.634	Cavia_porcellus
ENSG00000125901	MRPS26	100	77.561	ENSCCAG00000033550	-	100	77.561	Cebus_capucinus
ENSG00000125901	MRPS26	100	85.366	ENSCCAG00000028201	-	100	85.366	Cebus_capucinus
ENSG00000125901	MRPS26	100	89.268	ENSCATG00000042895	MRPS26	100	89.268	Cercocebus_atys
ENSG00000125901	MRPS26	100	73.171	ENSCLAG00000011719	MRPS26	100	73.171	Chinchilla_lanigera
ENSG00000125901	MRPS26	100	91.707	ENSCSAG00000013328	MRPS26	100	91.707	Chlorocebus_sabaeus
ENSG00000125901	MRPS26	97	51.759	ENSCPBG00000024567	MRPS26	82	50.495	Chrysemys_picta_bellii
ENSG00000125901	MRPS26	100	92.195	ENSCANG00000036635	MRPS26	100	92.195	Colobus_angolensis_palliatus
ENSG00000125901	MRPS26	97	71.859	ENSCGRG00001018911	Mrps26	99	71.859	Cricetulus_griseus_chok1gshd
ENSG00000125901	MRPS26	97	71.357	ENSCGRG00000012015	Mrps26	99	71.357	Cricetulus_griseus_crigri
ENSG00000125901	MRPS26	97	47.030	ENSCSEG00000012756	mrps26	98	47.030	Cynoglossus_semilaevis
ENSG00000125901	MRPS26	94	49.741	ENSCVAG00000019048	mrps26	93	49.741	Cyprinodon_variegatus
ENSG00000125901	MRPS26	97	48.558	ENSDARG00000039719	mrps26	98	48.558	Danio_rerio
ENSG00000125901	MRPS26	98	77.000	ENSDNOG00000024910	MRPS26	99	77.000	Dasypus_novemcinctus
ENSG00000125901	MRPS26	85	73.563	ENSDORG00000012900	Mrps26	99	72.000	Dipodomys_ordii
ENSG00000125901	MRPS26	98	38.119	ENSEBUG00000011417	mrps26	98	38.119	Eptatretus_burgeri
ENSG00000125901	MRPS26	100	77.512	ENSEASG00005013030	MRPS26	100	77.512	Equus_asinus_asinus
ENSG00000125901	MRPS26	100	77.990	ENSECAG00000008620	MRPS26	100	77.990	Equus_caballus
ENSG00000125901	MRPS26	100	72.195	ENSEEUG00000013785	MRPS26	100	72.195	Erinaceus_europaeus
ENSG00000125901	MRPS26	88	44.444	ENSELUG00000002003	mrps26	87	44.809	Esox_lucius
ENSG00000125901	MRPS26	100	78.049	ENSFCAG00000028185	MRPS26	100	78.049	Felis_catus
ENSG00000125901	MRPS26	94	48.309	ENSFALG00000000213	MRPS26	97	49.020	Ficedula_albicollis
ENSG00000125901	MRPS26	82	68.452	ENSFDAG00000012758	MRPS26	99	68.452	Fukomys_damarensis
ENSG00000125901	MRPS26	97	46.535	ENSFHEG00000005576	mrps26	98	46.535	Fundulus_heteroclitus
ENSG00000125901	MRPS26	90	49.730	ENSGMOG00000015969	mrps26	90	49.730	Gadus_morhua
ENSG00000125901	MRPS26	89	49.189	ENSGALG00000014118	MRPS26	60	49.189	Gallus_gallus
ENSG00000125901	MRPS26	90	49.730	ENSGAFG00000017591	mrps26	89	48.404	Gambusia_affinis
ENSG00000125901	MRPS26	89	48.634	ENSGACG00000004920	mrps26	96	43.363	Gasterosteus_aculeatus
ENSG00000125901	MRPS26	97	51.980	ENSGAGG00000016897	MRPS26	97	50.000	Gopherus_agassizii
ENSG00000125901	MRPS26	100	98.537	ENSGGOG00000005088	MRPS26	100	98.537	Gorilla_gorilla
ENSG00000125901	MRPS26	90	51.351	ENSHBUG00000010675	mrps26	89	50.270	Haplochromis_burtoni
ENSG00000125901	MRPS26	97	73.367	ENSHGLG00000014224	MRPS26	99	73.367	Heterocephalus_glaber_female
ENSG00000125901	MRPS26	97	73.367	ENSHGLG00100012471	MRPS26	99	73.367	Heterocephalus_glaber_male
ENSG00000125901	MRPS26	89	51.630	ENSHCOG00000011405	mrps26	91	49.727	Hippocampus_comes
ENSG00000125901	MRPS26	95	48.718	ENSIPUG00000006044	Mrps26	94	46.465	Ictalurus_punctatus
ENSG00000125901	MRPS26	100	77.073	ENSSTOG00000026786	MRPS26	100	77.073	Ictidomys_tridecemlineatus
ENSG00000125901	MRPS26	97	72.000	ENSJJAG00000021092	Mrps26	99	72.000	Jaculus_jaculus
ENSG00000125901	MRPS26	90	50.000	ENSKMAG00000016658	mrps26	89	50.000	Kryptolebias_marmoratus
ENSG00000125901	MRPS26	90	50.270	ENSLBEG00000027491	mrps26	90	50.270	Labrus_bergylta
ENSG00000125901	MRPS26	97	46.040	ENSLACG00000012161	MRPS26	99	46.040	Latimeria_chalumnae
ENSG00000125901	MRPS26	88	48.901	ENSLOCG00000002051	mrps26	87	48.901	Lepisosteus_oculatus
ENSG00000125901	MRPS26	93	72.105	ENSLAFG00000007936	MRPS26	95	72.105	Loxodonta_africana
ENSG00000125901	MRPS26	100	89.756	ENSMFAG00000029490	MRPS26	100	89.756	Macaca_fascicularis
ENSG00000125901	MRPS26	100	89.756	ENSMNEG00000033521	MRPS26	100	89.756	Macaca_nemestrina
ENSG00000125901	MRPS26	90	51.351	ENSMAMG00000000108	mrps26	89	51.351	Mastacembelus_armatus
ENSG00000125901	MRPS26	90	51.351	ENSMZEG00005014646	mrps26	89	50.270	Maylandia_zebra
ENSG00000125901	MRPS26	75	49.682	ENSMGAG00000013227	MRPS26	97	49.682	Meleagris_gallopavo
ENSG00000125901	MRPS26	97	72.362	ENSMAUG00000019571	Mrps26	99	72.362	Mesocricetus_auratus
ENSG00000125901	MRPS26	100	79.512	ENSMICG00000013793	MRPS26	100	79.512	Microcebus_murinus
ENSG00000125901	MRPS26	97	72.864	ENSMOCG00000016053	MRPS26	99	72.864	Microtus_ochrogaster
ENSG00000125901	MRPS26	97	49.010	ENSMMOG00000021376	mrps26	98	47.030	Mola_mola
ENSG00000125901	MRPS26	98	57.843	ENSMODG00000005409	MRPS26	98	57.843	Monodelphis_domestica
ENSG00000125901	MRPS26	91	46.524	ENSMALG00000002393	mrps26	90	46.316	Monopterus_albus
ENSG00000125901	MRPS26	97	69.849	MGP_CAROLIEiJ_G0024305	Mrps26	99	69.849	Mus_caroli
ENSG00000125901	MRPS26	97	70.352	ENSMUSG00000037740	Mrps26	99	70.352	Mus_musculus
ENSG00000125901	MRPS26	97	71.357	MGP_PahariEiJ_G0025750	Mrps26	99	71.357	Mus_pahari
ENSG00000125901	MRPS26	97	70.352	MGP_SPRETEiJ_G0025225	Mrps26	99	70.352	Mus_spretus
ENSG00000125901	MRPS26	100	76.585	ENSMPUG00000009018	MRPS26	100	76.585	Mustela_putorius_furo
ENSG00000125901	MRPS26	100	75.122	ENSNGAG00000013778	Mrps26	100	75.122	Nannospalax_galili
ENSG00000125901	MRPS26	90	51.351	ENSNBRG00000024142	mrps26	89	50.270	Neolamprologus_brichardi
ENSG00000125901	MRPS26	100	97.073	ENSNLEG00000027041	MRPS26	100	97.073	Nomascus_leucogenys
ENSG00000125901	MRPS26	97	73.869	ENSODEG00000004501	MRPS26	100	73.869	Octodon_degus
ENSG00000125901	MRPS26	90	51.351	ENSONIG00000012266	mrps26	89	50.270	Oreochromis_niloticus
ENSG00000125901	MRPS26	94	79.688	ENSOCUG00000012218	MRPS26	100	77.404	Oryctolagus_cuniculus
ENSG00000125901	MRPS26	90	54.839	ENSORLG00000022499	mrps26	89	53.763	Oryzias_latipes
ENSG00000125901	MRPS26	90	54.301	ENSORLG00020008696	mrps26	89	51.596	Oryzias_latipes_hni
ENSG00000125901	MRPS26	90	54.301	ENSORLG00015006028	mrps26	89	53.226	Oryzias_latipes_hsok
ENSG00000125901	MRPS26	88	54.144	ENSOMEG00000009374	mrps26	87	53.591	Oryzias_melastigma
ENSG00000125901	MRPS26	100	73.171	ENSOGAG00000025385	MRPS26	100	73.171	Otolemur_garnettii
ENSG00000125901	MRPS26	51	70.192	ENSOARG00000015332	-	98	70.192	Ovis_aries
ENSG00000125901	MRPS26	100	77.561	ENSPPRG00000004446	MRPS26	100	77.561	Panthera_pardus
ENSG00000125901	MRPS26	100	100.000	ENSPTRG00000013188	MRPS26	100	100.000	Pan_troglodytes
ENSG00000125901	MRPS26	100	89.268	ENSPANG00000004889	MRPS26	100	89.268	Papio_anubis
ENSG00000125901	MRPS26	91	46.842	ENSPKIG00000020131	mrps26	92	46.842	Paramormyrops_kingsleyae
ENSG00000125901	MRPS26	59	50.407	ENSPSIG00000016604	MRPS26	95	47.154	Pelodiscus_sinensis
ENSG00000125901	MRPS26	95	47.179	ENSPMGG00000005875	mrps26	98	47.317	Periophthalmus_magnuspinnatus
ENSG00000125901	MRPS26	97	73.869	ENSPEMG00000010334	Mrps26	99	73.869	Peromyscus_maniculatus_bairdii
ENSG00000125901	MRPS26	91	41.969	ENSPMAG00000000253	mrps26	62	44.103	Petromyzon_marinus
ENSG00000125901	MRPS26	86	58.757	ENSPCIG00000000516	MRPS26	97	56.373	Phascolarctos_cinereus
ENSG00000125901	MRPS26	90	49.189	ENSPFOG00000009251	mrps26	89	49.189	Poecilia_formosa
ENSG00000125901	MRPS26	90	49.189	ENSPLAG00000022482	mrps26	89	49.189	Poecilia_latipinna
ENSG00000125901	MRPS26	90	48.649	ENSPMEG00000015504	mrps26	89	48.649	Poecilia_mexicana
ENSG00000125901	MRPS26	90	48.649	ENSPREG00000007165	mrps26	89	48.649	Poecilia_reticulata
ENSG00000125901	MRPS26	100	96.585	ENSPPYG00000010829	MRPS26	100	96.585	Pongo_abelii
ENSG00000125901	MRPS26	100	73.659	ENSPCAG00000008861	MRPS26	100	73.659	Procavia_capensis
ENSG00000125901	MRPS26	100	80.976	ENSPCOG00000021945	MRPS26	100	80.976	Propithecus_coquereli
ENSG00000125901	MRPS26	100	79.612	ENSPVAG00000006837	MRPS26	100	79.612	Pteropus_vampyrus
ENSG00000125901	MRPS26	90	50.270	ENSPNYG00000018207	mrps26	89	50.270	Pundamilia_nyererei
ENSG00000125901	MRPS26	90	48.980	ENSPNAG00000018408	mrps26	97	48.544	Pygocentrus_nattereri
ENSG00000125901	MRPS26	97	69.849	ENSRNOG00000021224	Mrps26	99	69.849	Rattus_norvegicus
ENSG00000125901	MRPS26	100	89.756	ENSRBIG00000031683	MRPS26	100	89.756	Rhinopithecus_bieti
ENSG00000125901	MRPS26	100	90.244	ENSRROG00000039447	MRPS26	100	90.244	Rhinopithecus_roxellana
ENSG00000125901	MRPS26	65	85.821	ENSSBOG00000020407	MRPS26	100	85.821	Saimiri_boliviensis_boliviensis
ENSG00000125901	MRPS26	85	57.143	ENSSHAG00000001164	-	87	55.122	Sarcophilus_harrisii
ENSG00000125901	MRPS26	93	53.266	ENSSMAG00000007897	mrps26	95	50.505	Scophthalmus_maximus
ENSG00000125901	MRPS26	90	50.811	ENSSDUG00000003187	mrps26	89	49.730	Seriola_dumerili
ENSG00000125901	MRPS26	90	50.270	ENSSLDG00000009389	mrps26	89	49.189	Seriola_lalandi_dorsalis
ENSG00000125901	MRPS26	58	71.186	ENSSARG00000013325	-	98	71.186	Sorex_araneus
ENSG00000125901	MRPS26	68	56.338	ENSSPUG00000008616	MRPS26	67	52.817	Sphenodon_punctatus
ENSG00000125901	MRPS26	90	51.075	ENSSPAG00000014577	mrps26	89	45.946	Stegastes_partitus
ENSG00000125901	MRPS26	100	75.610	ENSSSCG00000007165	MRPS26	100	75.610	Sus_scrofa
ENSG00000125901	MRPS26	85	45.506	ENSTGUG00000010977	MRPS26	100	44.199	Taeniopygia_guttata
ENSG00000125901	MRPS26	90	50.811	ENSTRUG00000017617	mrps26	89	50.811	Takifugu_rubripes
ENSG00000125901	MRPS26	90	51.892	ENSTNIG00000001213	mrps26	88	51.892	Tetraodon_nigroviridis
ENSG00000125901	MRPS26	99	58.049	ENSTBEG00000004072	MRPS26	99	58.049	Tupaia_belangeri
ENSG00000125901	MRPS26	100	79.512	ENSTTRG00000011959	MRPS26	100	79.512	Tursiops_truncatus
ENSG00000125901	MRPS26	100	77.073	ENSUAMG00000007581	MRPS26	94	77.073	Ursus_americanus
ENSG00000125901	MRPS26	71	73.288	ENSUMAG00000002754	MRPS26	74	67.879	Ursus_maritimus
ENSG00000125901	MRPS26	100	75.728	ENSVVUG00000025435	MRPS26	100	75.728	Vulpes_vulpes
ENSG00000125901	MRPS26	90	48.649	ENSXMAG00000025028	mrps26	89	48.649	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005739	mitochondrion	21873635.	IBA	Component
GO:0005739	mitochondrion	-	IDA	Component
GO:0005743	mitochondrial inner membrane	-	TAS	Component
GO:0005763	mitochondrial small ribosomal subunit	21873635.	IBA	Component
GO:0005763	mitochondrial small ribosomal subunit	11279123.	NAS	Component
GO:0042769	DNA damage response, detection of DNA damage	15300802.	NAS	Process
GO:0070125	mitochondrial translational elongation	-	TAS	Process
GO:0070126	mitochondrial translational termination	-	TAS	Process

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr20	3046166	Missense_Mutation	rs772959814	P33L	0.08	MRP-S26
BLCA	chr20	3047829	Missense_Mutation	novel	R193T	0.07	MRP-S26
BLCA	chr20	3046487	Silent	novel	N109N	0.25
BRCA	chr20	3047834	Missense_Mutation	NA	G195W	0.26	MRP-S26
BRCA	chr20	3046428	Missense_Mutation	novel	L90V	0.49	MRP-S26
CESC	chr20	3046238	Missense_Mutation	novel	M57T	0.56	MRP-S26
COAD	chr20	3046244	Missense_Mutation	novel	R59H	0.29	MRP-S26
ESCA	chr20	3047820	Missense_Mutation	novel	A190V	0.21	MRP-S26
KIRC	chr20	3047847	Missense_Mutation	NA	R199T	0.4
LGG	chr20	3046411	Missense_Mutation	NA	E84G	0.32	MRP-S26
LGG	chr20	3047834	Missense_Mutation	novel	G195R	0.12	MRP-S26
LIHC	chr20	3046716	Missense_Mutation	novel	E154D	0.39	MRP-S26
LUAD	chr20	3047839	Silent	novel	L196L	0.15
LUAD	chr20	3046475	Silent	novel	L105L	0.48
OV	chr20	3047940	3'UTR	novel		0.29
OV	chr20	3046239	Missense_Mutation	novel	M57I	0.15	MRP-S26
SKCM	chr20	3046230	Silent	rs778372833	F54F	0.33
UCEC	chr20	3048036	3'UTR	novel		0.57
UCEC	chr20	3047855	Missense_Mutation	rs778955627	R202C	0.27
UCEC	chr20	3047855	Missense_Mutation	rs778955627	R202C	0.36
UCEC	chr20	3047826	Missense_Mutation	novel	T192I	0.44	MRP-S26
UCEC	chr20	3046414	Missense_Mutation	novel	A85V	0.24	MRP-S26
UCEC	chr20	3046506	Silent	novel	L116L	0.41
UCEC	chr20	3046701	Nonsense_Mutation	novel	W149*	0.26	MRP-S26
UCEC	chr20	3046204	Missense_Mutation	novel	P46T	0.33	MRP-S26
UCEC	chr20	3047917	3'UTR	rs377261339		0.74
UCEC	chr20	3046217	Missense_Mutation	novel	P50L	0.4	MRP-S26

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.1556	0.030954
LUAD	DEL	0.1996	0.15188
OV	AMP	0.5009	0.059168
TGCT	DEL	0.1867	0.14117
UCEC	AMP	0.1744	0.12846

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00051	Kaplan-Meier Survival Analysis
ESCA	0.0066	Kaplan-Meier Survival Analysis
PAAD	0.013	Kaplan-Meier Survival Analysis
BLCA	0.0035	Kaplan-Meier Survival Analysis
LIHC	0.038	Kaplan-Meier Survival Analysis
CHOL	0.047	Kaplan-Meier Survival Analysis
UVM	0.0043	Kaplan-Meier Survival Analysis
OV	0.017	Kaplan-Meier Survival Analysis