EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000126070 (Gene tree)
Gene ID: 192669
Gene Symbol: AGO3
Alias: hAGO3|FLJ12765|EIF2C3
Full Name: argonaute RISC catalytic component 3
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 149,098 bases
Position: chr1:35,923,403-36,072,500
Accession: 18421
RBP type: canonical RBP
Summary: This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, contains a PAZ domain and a PIWI domain, and may play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a tandem cluster of closely related family members including argonaute 4 and eukaryotic translation initiation factor 2C, 1. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000246314	PAZ	PF02170.22	2.7e-27	1	1
ENSP00000362287	PAZ	PF02170.22	3.5e-27	1	1
ENSP00000246314	Piwi	PF02171.17	2.1e-113	1	1
ENSP00000362287	Piwi	PF02171.17	4.4e-113	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
21878547	Argonaute protein identity and pairing geometry determine cooperativity in mammalian RNA silencing.	RNA	2011 Oct	Broderick JA	doi: 10.1261/rna.2778911

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000471099	AGO3-205	602	-	-	- (aa)	-	-
ENST00000397828	AGO3-204	1035	-	ENSP00000380928	229 (aa)	-	Q5TA56
ENST00000373191	AGO3-203	19687	XM_005270575	ENSP00000362287	860 (aa)	XP_005270632	Q9H9G7
ENST00000634486	AGO3-207	3599	-	ENSP00000489286	64 (aa)	-	A0A0U1RR19
ENST00000324350	AGO3-202	1726	-	ENSP00000317425	229 (aa)	-	Q5TA56
ENST00000491443	AGO3-206	548	-	-	- (aa)	-	-
ENST00000246314	AGO3-201	3211	XM_005270576	ENSP00000246314	626 (aa)	XP_005270633	Q9H9G7

Gene Model

Click here to download ENSG00000126070's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000126070	rs491603	1	36066715	A	Barrett's esophagus x BMI interaction	29551738		1.08	EFO_0000280\|EFO_0004340

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000126070's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000126070	AGO3	100	85.737	ENSG00000134698	AGO4	99	80.876
ENSG00000126070	AGO3	100	89.617	ENSG00000092847	AGO1	100	85.461
ENSG00000126070	AGO3	100	85.623	ENSG00000123908	AGO2	99	79.745

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000126070	AGO3	100	98.403	ENSAPOG00000024260	ago3a	100	97.093	Acanthochromis_polyacanthus
ENSG00000126070	AGO3	100	96.524	ENSAPOG00000014494	-	100	94.579	Acanthochromis_polyacanthus
ENSG00000126070	AGO3	100	100.000	ENSAMEG00000000497	AGO3	100	99.884	Ailuropoda_melanoleuca
ENSG00000126070	AGO3	100	98.403	ENSACIG00000005333	ago3a	100	97.851	Amphilophus_citrinellus
ENSG00000126070	AGO3	100	97.284	ENSACIG00000019272	AGO3	100	95.828	Amphilophus_citrinellus
ENSG00000126070	AGO3	100	87.859	ENSAOCG00000017051	-	100	88.080	Amphiprion_ocellaris
ENSG00000126070	AGO3	96	85.845	ENSAOCG00000022538	-	91	89.144	Amphiprion_ocellaris
ENSG00000126070	AGO3	100	98.403	ENSAOCG00000017642	ago3a	100	97.093	Amphiprion_ocellaris
ENSG00000126070	AGO3	100	96.524	ENSAPEG00000020249	-	100	94.233	Amphiprion_percula
ENSG00000126070	AGO3	100	97.314	ENSAPEG00000004375	ago3a	100	96.309	Amphiprion_percula
ENSG00000126070	AGO3	100	97.314	ENSATEG00000008458	ago3a	100	96.309	Anabas_testudineus
ENSG00000126070	AGO3	100	96.367	ENSATEG00000005160	-	100	94.118	Anabas_testudineus
ENSG00000126070	AGO3	100	99.362	ENSAPLG00000009642	AGO3	99	99.416	Anas_platyrhynchos
ENSG00000126070	AGO3	100	99.361	ENSACAG00000003385	AGO3	100	99.186	Anolis_carolinensis
ENSG00000126070	AGO3	100	100.000	ENSANAG00000037735	AGO3	100	100.000	Aotus_nancymaae
ENSG00000126070	AGO3	100	96.051	ENSACLG00000001965	-	100	94.002	Astatotilapia_calliptera
ENSG00000126070	AGO3	100	98.403	ENSACLG00000000963	ago3a	100	97.093	Astatotilapia_calliptera
ENSG00000126070	AGO3	100	95.687	ENSAMXG00000002198	ago3a	100	95.702	Astyanax_mexicanus
ENSG00000126070	AGO3	100	94.888	ENSAMXG00000009571	ago3b	100	94.564	Astyanax_mexicanus
ENSG00000126070	AGO3	100	100.000	ENSBTAG00000018324	AGO3	100	99.884	Bos_taurus
ENSG00000126070	AGO3	100	100.000	ENSCJAG00000031580	AGO3	100	100.000	Callithrix_jacchus
ENSG00000126070	AGO3	100	99.840	ENSCAFG00000024682	AGO3	100	99.767	Canis_familiaris
ENSG00000126070	AGO3	100	100.000	ENSCAFG00020009051	AGO3	99	100.000	Canis_lupus_dingo
ENSG00000126070	AGO3	100	100.000	ENSCHIG00000011536	AGO3	100	99.884	Capra_hircus
ENSG00000126070	AGO3	100	98.438	ENSTSYG00000011897	AGO3	100	99.862	Carlito_syrichta
ENSG00000126070	AGO3	100	81.629	ENSCAPG00000011589	AGO3	100	81.101	Cavia_aperea
ENSG00000126070	AGO3	99	96.257	ENSCPOG00000030524	AGO3	100	96.257	Cavia_porcellus
ENSG00000126070	AGO3	100	100.000	ENSCCAG00000034189	AGO3	100	100.000	Cebus_capucinus
ENSG00000126070	AGO3	100	100.000	ENSCATG00000029748	AGO3	100	100.000	Cercocebus_atys
ENSG00000126070	AGO3	100	100.000	ENSCLAG00000013184	AGO3	100	99.884	Chinchilla_lanigera
ENSG00000126070	AGO3	100	100.000	ENSCSAG00000001092	AGO3	100	100.000	Chlorocebus_sabaeus
ENSG00000126070	AGO3	92	100.000	ENSCHOG00000011621	AGO3	92	100.000	Choloepus_hoffmanni
ENSG00000126070	AGO3	100	99.535	ENSCPBG00000018583	AGO3	100	99.535	Chrysemys_picta_bellii
ENSG00000126070	AGO3	100	100.000	ENSCANG00000033258	AGO3	100	100.000	Colobus_angolensis_palliatus
ENSG00000126070	AGO3	100	99.840	ENSCGRG00001024614	Ago3	100	99.535	Cricetulus_griseus_chok1gshd
ENSG00000126070	AGO3	100	99.840	ENSCGRG00000010670	Ago3	100	99.535	Cricetulus_griseus_crigri
ENSG00000126070	AGO3	100	98.083	ENSCSEG00000001040	ago3a	100	97.345	Cynoglossus_semilaevis
ENSG00000126070	AGO3	100	89.937	ENSCSEG00000009788	-	100	90.387	Cynoglossus_semilaevis
ENSG00000126070	AGO3	100	98.083	ENSCVAG00000018224	ago3a	100	96.744	Cyprinodon_variegatus
ENSG00000126070	AGO3	94	90.233	ENSCVAG00000011229	-	98	87.061	Cyprinodon_variegatus
ENSG00000126070	AGO3	100	97.314	ENSDARG00000059888	ago3a	100	96.194	Danio_rerio
ENSG00000126070	AGO3	100	97.284	ENSDARG00000063079	ago3b	100	95.116	Danio_rerio
ENSG00000126070	AGO3	100	98.438	ENSDNOG00000008106	AGO3	100	99.868	Dasypus_novemcinctus
ENSG00000126070	AGO3	100	100.000	ENSDORG00000009414	Ago3	100	99.535	Dipodomys_ordii
ENSG00000126070	AGO3	88	98.214	ENSETEG00000007639	AGO3	89	98.592	Echinops_telfairi
ENSG00000126070	AGO3	100	100.000	ENSEASG00005012089	AGO3	100	99.884	Equus_asinus_asinus
ENSG00000126070	AGO3	100	100.000	ENSECAG00000023972	AGO3	100	99.884	Equus_caballus
ENSG00000126070	AGO3	100	98.438	ENSEEUG00000007058	AGO3	100	82.907	Erinaceus_europaeus
ENSG00000126070	AGO3	100	94.410	ENSELUG00000001774	-	100	93.736	Esox_lucius
ENSG00000126070	AGO3	100	94.409	ENSELUG00000016755	ago3a	100	94.817	Esox_lucius
ENSG00000126070	AGO3	100	100.000	ENSFCAG00000000747	-	100	100.000	Felis_catus
ENSG00000126070	AGO3	100	99.362	ENSFALG00000000802	AGO3	99	99.299	Ficedula_albicollis
ENSG00000126070	AGO3	100	100.000	ENSFDAG00000012874	AGO3	100	99.883	Fukomys_damarensis
ENSG00000126070	AGO3	100	94.629	ENSFHEG00000016205	-	100	93.080	Fundulus_heteroclitus
ENSG00000126070	AGO3	100	97.764	ENSGMOG00000013069	-	100	96.886	Gadus_morhua
ENSG00000126070	AGO3	87	79.599	ENSGMOG00000019418	-	89	78.455	Gadus_morhua
ENSG00000126070	AGO3	100	99.521	ENSGALG00000043711	AGO3	100	99.645	Gallus_gallus
ENSG00000126070	AGO3	100	94.629	ENSGAFG00000015911	-	100	93.080	Gambusia_affinis
ENSG00000126070	AGO3	100	98.403	ENSGAFG00000009808	ago3a	100	96.977	Gambusia_affinis
ENSG00000126070	AGO3	100	96.965	ENSGACG00000002455	AGO3	100	95.569	Gasterosteus_aculeatus
ENSG00000126070	AGO3	100	97.615	ENSGACG00000012453	ago3a	100	97.240	Gasterosteus_aculeatus
ENSG00000126070	AGO3	100	99.535	ENSGAGG00000012887	AGO3	100	99.535	Gopherus_agassizii
ENSG00000126070	AGO3	100	100.000	ENSGGOG00000036711	AGO3	100	100.000	Gorilla_gorilla
ENSG00000126070	AGO3	100	96.051	ENSHBUG00000017794	-	100	94.002	Haplochromis_burtoni
ENSG00000126070	AGO3	96	92.694	ENSHBUG00000010542	ago3a	97	95.478	Haplochromis_burtoni
ENSG00000126070	AGO3	100	100.000	ENSHGLG00000012538	AGO3	100	99.884	Heterocephalus_glaber_female
ENSG00000126070	AGO3	100	99.361	ENSHGLG00100006043	AGO3	100	99.529	Heterocephalus_glaber_male
ENSG00000126070	AGO3	89	96.552	ENSHCOG00000005674	ago3a	97	96.107	Hippocampus_comes
ENSG00000126070	AGO3	100	95.103	ENSHCOG00000011851	AGO3	100	93.195	Hippocampus_comes
ENSG00000126070	AGO3	60	97.878	ENSHCOG00000005654	ago3a	100	97.878	Hippocampus_comes
ENSG00000126070	AGO3	100	97.444	ENSIPUG00000008548	ago3b	100	94.810	Ictalurus_punctatus
ENSG00000126070	AGO3	100	91.242	ENSIPUG00000023241	ago3a	99	91.638	Ictalurus_punctatus
ENSG00000126070	AGO3	100	100.000	ENSSTOG00000025904	AGO3	100	95.116	Ictidomys_tridecemlineatus
ENSG00000126070	AGO3	100	100.000	ENSJJAG00000017436	Ago3	100	99.767	Jaculus_jaculus
ENSG00000126070	AGO3	100	97.314	ENSKMAG00000019534	ago3a	100	96.309	Kryptolebias_marmoratus
ENSG00000126070	AGO3	100	98.243	ENSLBEG00000007592	ago3a	100	97.851	Labrus_bergylta
ENSG00000126070	AGO3	100	94.876	ENSLBEG00000016073	-	100	93.850	Labrus_bergylta
ENSG00000126070	AGO3	100	100.000	ENSLAFG00000002744	AGO3	100	99.884	Loxodonta_africana
ENSG00000126070	AGO3	100	100.000	ENSMFAG00000035610	AGO3	100	100.000	Macaca_fascicularis
ENSG00000126070	AGO3	100	100.000	ENSMMUG00000006252	AGO3	100	100.000	Macaca_mulatta
ENSG00000126070	AGO3	100	100.000	ENSMNEG00000039518	AGO3	100	100.000	Macaca_nemestrina
ENSG00000126070	AGO3	100	100.000	ENSMLEG00000027912	AGO3	100	100.000	Mandrillus_leucophaeus
ENSG00000126070	AGO3	100	97.284	ENSMAMG00000008440	ago3a	100	97.092	Mastacembelus_armatus
ENSG00000126070	AGO3	100	96.051	ENSMAMG00000005697	-	100	93.887	Mastacembelus_armatus
ENSG00000126070	AGO3	100	98.403	ENSMZEG00005007949	ago3a	100	97.093	Maylandia_zebra
ENSG00000126070	AGO3	100	96.051	ENSMZEG00005026243	-	100	94.118	Maylandia_zebra
ENSG00000126070	AGO3	100	99.362	ENSMGAG00000003773	AGO3	99	99.415	Meleagris_gallopavo
ENSG00000126070	AGO3	95	89.447	ENSMAUG00000010128	Ago3	96	87.060	Mesocricetus_auratus
ENSG00000126070	AGO3	100	100.000	ENSMICG00000016158	AGO3	100	99.884	Microcebus_murinus
ENSG00000126070	AGO3	100	96.006	ENSMOCG00000020568	Ago3	99	96.503	Microtus_ochrogaster
ENSG00000126070	AGO3	100	91.732	ENSMMOG00000018446	ago3a	100	92.680	Mola_mola
ENSG00000126070	AGO3	100	94.249	ENSMMOG00000014065	-	100	93.552	Mola_mola
ENSG00000126070	AGO3	100	99.521	ENSMODG00000017869	AGO3	100	99.186	Monodelphis_domestica
ENSG00000126070	AGO3	100	94.728	ENSMALG00000010895	ago3a	99	94.569	Monopterus_albus
ENSG00000126070	AGO3	100	93.770	ENSMALG00000014658	-	99	93.034	Monopterus_albus
ENSG00000126070	AGO3	100	99.681	MGP_CAROLIEiJ_G0026477	Ago3	100	99.186	Mus_caroli
ENSG00000126070	AGO3	100	99.840	ENSMUSG00000028842	Ago3	100	98.953	Mus_musculus
ENSG00000126070	AGO3	100	99.840	MGP_PahariEiJ_G0028808	Ago3	100	99.070	Mus_pahari
ENSG00000126070	AGO3	100	99.840	MGP_SPRETEiJ_G0027456	Ago3	100	99.302	Mus_spretus
ENSG00000126070	AGO3	100	99.840	ENSMLUG00000009668	AGO3	100	99.840	Myotis_lucifugus
ENSG00000126070	AGO3	100	99.681	ENSNGAG00000012607	Ago3	100	99.535	Nannospalax_galili
ENSG00000126070	AGO3	100	97.125	ENSNBRG00000015687	AGO3	100	95.702	Neolamprologus_brichardi
ENSG00000126070	AGO3	100	86.234	ENSNBRG00000010936	ago3a	100	88.805	Neolamprologus_brichardi
ENSG00000126070	AGO3	99	95.662	ENSNLEG00000027092	AGO3	99	95.662	Nomascus_leucogenys
ENSG00000126070	AGO3	94	84.915	ENSMEUG00000009200	AGO3	91	86.308	Notamacropus_eugenii
ENSG00000126070	AGO3	100	98.438	ENSOPRG00000012344	AGO3	82	100.000	Ochotona_princeps
ENSG00000126070	AGO3	100	100.000	ENSODEG00000005161	AGO3	100	99.883	Octodon_degus
ENSG00000126070	AGO3	100	98.403	ENSONIG00000016349	ago3a	100	96.977	Oreochromis_niloticus
ENSG00000126070	AGO3	100	97.284	ENSONIG00000013760	AGO3	100	94.233	Oreochromis_niloticus
ENSG00000126070	AGO3	100	99.362	ENSOANG00000002078	AGO3	100	99.527	Ornithorhynchus_anatinus
ENSG00000126070	AGO3	100	100.000	ENSOCUG00000006255	AGO3	100	99.884	Oryctolagus_cuniculus
ENSG00000126070	AGO3	100	98.243	ENSORLG00000015016	ago3a	100	97.977	Oryzias_latipes
ENSG00000126070	AGO3	100	95.527	ENSORLG00000009091	-	100	92.558	Oryzias_latipes
ENSG00000126070	AGO3	100	95.527	ENSORLG00020015386	AGO3	100	92.558	Oryzias_latipes_hni
ENSG00000126070	AGO3	100	95.367	ENSORLG00015006205	-	100	92.442	Oryzias_latipes_hsok
ENSG00000126070	AGO3	100	98.243	ENSORLG00015000087	ago3a	100	97.977	Oryzias_latipes_hsok
ENSG00000126070	AGO3	100	95.687	ENSOMEG00000022085	-	100	92.907	Oryzias_melastigma
ENSG00000126070	AGO3	100	98.243	ENSOMEG00000020588	ago3a	100	97.851	Oryzias_melastigma
ENSG00000126070	AGO3	100	100.000	ENSOGAG00000010290	AGO3	100	99.884	Otolemur_garnettii
ENSG00000126070	AGO3	100	100.000	ENSOARG00000019609	AGO3	100	99.884	Ovis_aries
ENSG00000126070	AGO3	100	100.000	ENSPPAG00000031959	AGO3	100	100.000	Pan_paniscus
ENSG00000126070	AGO3	100	100.000	ENSPPRG00000005934	AGO3	100	100.000	Panthera_pardus
ENSG00000126070	AGO3	100	100.000	ENSPTIG00000001029	AGO3	99	99.883	Panthera_tigris_altaica
ENSG00000126070	AGO3	100	100.000	ENSPTRG00000000529	AGO3	100	100.000	Pan_troglodytes
ENSG00000126070	AGO3	100	100.000	ENSPANG00000007682	AGO3	100	100.000	Papio_anubis
ENSG00000126070	AGO3	96	99.027	ENSPSIG00000007162	AGO3	100	99.027	Pelodiscus_sinensis
ENSG00000126070	AGO3	100	97.284	ENSPMGG00000013215	-	100	96.081	Periophthalmus_magnuspinnatus
ENSG00000126070	AGO3	100	97.125	ENSPMGG00000024101	ago3a	100	96.966	Periophthalmus_magnuspinnatus
ENSG00000126070	AGO3	99	94.379	ENSPEMG00000024271	-	100	94.379	Peromyscus_maniculatus_bairdii
ENSG00000126070	AGO3	100	99.361	ENSPCIG00000000198	AGO3	100	99.070	Phascolarctos_cinereus
ENSG00000126070	AGO3	100	95.231	ENSPFOG00000006684	-	99	94.152	Poecilia_formosa
ENSG00000126070	AGO3	100	97.314	ENSPLAG00000002848	ago3a	100	96.309	Poecilia_latipinna
ENSG00000126070	AGO3	99	93.269	ENSPLAG00000017432	-	100	90.464	Poecilia_latipinna
ENSG00000126070	AGO3	100	94.787	ENSPMEG00000004268	-	100	93.310	Poecilia_mexicana
ENSG00000126070	AGO3	100	98.403	ENSPMEG00000001806	ago3a	100	96.977	Poecilia_mexicana
ENSG00000126070	AGO3	91	91.346	ENSPREG00000009084	-	99	96.029	Poecilia_reticulata
ENSG00000126070	AGO3	100	97.314	ENSPREG00000006604	ago3a	100	96.194	Poecilia_reticulata
ENSG00000126070	AGO3	100	100.000	ENSPPYG00000001550	AGO3	100	100.000	Pongo_abelii
ENSG00000126070	AGO3	93	99.528	ENSPCAG00000010090	AGO3	100	87.002	Procavia_capensis
ENSG00000126070	AGO3	100	100.000	ENSPCOG00000028390	AGO3	100	99.884	Propithecus_coquereli
ENSG00000126070	AGO3	100	99.840	ENSPVAG00000005086	AGO3	100	99.535	Pteropus_vampyrus
ENSG00000126070	AGO3	100	97.125	ENSPNYG00000004707	-	100	94.884	Pundamilia_nyererei
ENSG00000126070	AGO3	100	97.314	ENSPNYG00000012510	ago3a	100	96.194	Pundamilia_nyererei
ENSG00000126070	AGO3	100	97.444	ENSPNAG00000008825	ago3b	100	95.465	Pygocentrus_nattereri
ENSG00000126070	AGO3	100	98.083	ENSPNAG00000008033	ago3a	100	96.628	Pygocentrus_nattereri
ENSG00000126070	AGO3	100	100.000	ENSRNOG00000034269	Ago3	100	99.651	Rattus_norvegicus
ENSG00000126070	AGO3	100	100.000	ENSRBIG00000043774	AGO3	100	100.000	Rhinopithecus_bieti
ENSG00000126070	AGO3	100	100.000	ENSRROG00000042180	AGO3	100	100.000	Rhinopithecus_roxellana
ENSG00000126070	AGO3	100	100.000	ENSSBOG00000029981	AGO3	100	100.000	Saimiri_boliviensis_boliviensis
ENSG00000126070	AGO3	100	95.048	ENSSFOG00015000162	ago3a	100	95.322	Scleropages_formosus
ENSG00000126070	AGO3	100	96.367	ENSSMAG00000001969	-	100	94.810	Scophthalmus_maximus
ENSG00000126070	AGO3	100	98.403	ENSSMAG00000002775	ago3a	100	97.229	Scophthalmus_maximus
ENSG00000126070	AGO3	100	96.965	ENSSDUG00000008069	-	100	95.828	Seriola_dumerili
ENSG00000126070	AGO3	100	98.403	ENSSDUG00000010918	ago3a	100	97.093	Seriola_dumerili
ENSG00000126070	AGO3	100	98.403	ENSSLDG00000000463	ago3a	100	97.977	Seriola_lalandi_dorsalis
ENSG00000126070	AGO3	100	97.764	ENSSLDG00000006859	-	100	96.460	Seriola_lalandi_dorsalis
ENSG00000126070	AGO3	100	98.438	ENSSARG00000011549	AGO3	92	99.392	Sorex_araneus
ENSG00000126070	AGO3	100	99.361	ENSSPUG00000000753	AGO3	99	99.062	Sphenodon_punctatus
ENSG00000126070	AGO3	100	97.314	ENSSPAG00000019104	ago3a	100	96.309	Stegastes_partitus
ENSG00000126070	AGO3	100	95.016	ENSSPAG00000015728	-	100	93.493	Stegastes_partitus
ENSG00000126070	AGO3	100	100.000	ENSSSCG00000003630	AGO3	100	100.000	Sus_scrofa
ENSG00000126070	AGO3	100	99.521	ENSTGUG00000014986	AGO3	100	99.532	Taeniopygia_guttata
ENSG00000126070	AGO3	100	96.486	ENSTRUG00000005992	ago3a	100	96.081	Takifugu_rubripes
ENSG00000126070	AGO3	100	96.051	ENSTRUG00000012737	-	100	93.656	Takifugu_rubripes
ENSG00000126070	AGO3	100	94.268	ENSTNIG00000002635	AGO3	98	91.803	Tetraodon_nigroviridis
ENSG00000126070	AGO3	100	98.438	ENSTBEG00000016565	AGO3	90	100.000	Tupaia_belangeri
ENSG00000126070	AGO3	100	100.000	ENSTTRG00000015092	AGO3	92	100.000	Tursiops_truncatus
ENSG00000126070	AGO3	100	100.000	ENSUAMG00000026574	AGO3	100	98.946	Ursus_americanus
ENSG00000126070	AGO3	60	100.000	ENSUMAG00000002033	-	100	100.000	Ursus_maritimus
ENSG00000126070	AGO3	100	99.840	ENSVPAG00000007631	AGO3	100	97.890	Vicugna_pacos
ENSG00000126070	AGO3	100	100.000	ENSVVUG00000000362	AGO3	100	100.000	Vulpes_vulpes
ENSG00000126070	AGO3	100	99.361	ENSXETG00000027042	ago3	99	98.830	Xenopus_tropicalis
ENSG00000126070	AGO3	100	93.997	ENSXCOG00000000902	-	99	93.971	Xiphophorus_couchianus
ENSG00000126070	AGO3	100	98.403	ENSXCOG00000007676	ago3a	100	98.399	Xiphophorus_couchianus
ENSG00000126070	AGO3	100	95.687	ENSXMAG00000027615	-	100	93.953	Xiphophorus_maculatus
ENSG00000126070	AGO3	100	97.314	ENSXMAG00000007141	ago3a	100	96.194	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000794	condensed nuclear chromosome	-	IEA	Component
GO:0000932	P-body	-	IEA	Component
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003725	double-stranded RNA binding	19966796.	IDA	Function
GO:0003727	single-stranded RNA binding	19966796.	IDA	Function
GO:0004521	endoribonuclease activity	29040713.	IMP	Function
GO:0005515	protein binding	19167051.19324964.19383768.22915799.23064648.28330616.	IPI	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005737	cytoplasm	15260970.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006402	mRNA catabolic process	18771919.	IDA	Process
GO:0007223	Wnt signaling pathway, calcium modulating pathway	-	TAS	Process
GO:0010501	RNA secondary structure unwinding	19966796.	IDA	Process
GO:0010501	RNA secondary structure unwinding	22795694.	IMP	Process
GO:0010628	positive regulation of gene expression	-	TAS	Process
GO:0010629	negative regulation of gene expression	-	TAS	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016442	RISC complex	15260970.19966796.	IDA	Component
GO:0031054	pre-miRNA processing	19966796.	IDA	Process
GO:0035068	micro-ribonucleoprotein complex	-	IEA	Component
GO:0035194	posttranscriptional gene silencing by RNA	-	TAS	Process
GO:0035196	production of miRNAs involved in gene silencing by miRNA	22795694.	IMP	Process
GO:0035198	miRNA binding	15260970.	IDA	Function
GO:0035278	miRNA mediated inhibition of translation	18771919.	IDA	Process
GO:0035279	mRNA cleavage involved in gene silencing by miRNA	15260970.	IDA	Process
GO:0035280	miRNA loading onto RISC involved in gene silencing by miRNA	19966796.	IDA	Process
GO:0036464	cytoplasmic ribonucleoprotein granule	-	IDA	Component
GO:0045652	regulation of megakaryocyte differentiation	-	TAS	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0070578	RISC-loading complex	19966796.	IDA	Component
GO:0072091	regulation of stem cell proliferation	23064648.	IMP	Process
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	-	IEA	Process
GO:0090624	endoribonuclease activity, cleaving miRNA-paired mRNA	29040713.	IMP	Function
GO:0090625	mRNA cleavage involved in gene silencing by siRNA	15260970.	IDA	Process
GO:1901224	positive regulation of NIK/NF-kappaB signaling	-	IEA	Process