EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000126432 (Gene tree)
Gene ID: 25824
Gene Symbol: PRDX5
Alias: ACR1|AOEB166|MGC142285|PRXV|PMP20|B166|PRDX6|PLP|SBBI10|MGC117264|MGC142283
Full Name: peroxiredoxin 5
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 3,736 bases
Position: chr11:64,318,088-64,321,823
Accession: 9355
RBP type: non-canonical RBP
Summary: This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein interacts with peroxisome receptor 1 and plays an antioxidant protective role in different tissues under normal conditions and during inflammatory processes. The use of alternate transcription start sites is thought to result in transcript variants that use different in-frame translational start codons to generate isoforms that are targeted to the mitochondrion (isoform L) or peroxisome/cytoplasm (isoform S). Multiple related pseudogenes have been defined for this gene. [provided by RefSeq, Nov 2017]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000265462	PRDX5-201	893	-	ENSP00000265462	214 (aa)	-	P30044
ENST00000352435	PRDX5-203	596	-	ENSP00000335334	170 (aa)	-	P30044
ENST00000347941	PRDX5-202	463	-	ENSP00000335363	125 (aa)	-	P30044

Gene Model

Click here to download ENSG00000126432's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04146	Peroxisome	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000126432's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001016	RNA polymerase III regulatory region DNA binding	10095767.	IDA	Function
GO:0004601	peroxidase activity	10521424.	IDA	Function
GO:0005102	signaling receptor binding	20178365.	IPI	Function
GO:0005515	protein binding	29128334.	IPI	Function
GO:0005615	extracellular space	23580065.	HDA	Component
GO:0005634	nucleus	10095767.15785239.	IDA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	15785239.	IDA	Component
GO:0005739	mitochondrion	21873635.	IBA	Component
GO:0005739	mitochondrion	10521424.10751410.18262354.	IDA	Component
GO:0005759	mitochondrial matrix	-	TAS	Component
GO:0005777	peroxisome	21873635.	IBA	Component
GO:0005777	peroxisome	10521424.	IDA	Component
GO:0005782	peroxisomal matrix	-	IEA	Component
GO:0005829	cytosol	18262354.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006915	apoptotic process	-	IEA	Process
GO:0006954	inflammatory response	10521424.	TAS	Process
GO:0006979	response to oxidative stress	10521424.	IDA	Process
GO:0008379	thioredoxin peroxidase activity	15280035.	EXP	Function
GO:0008379	thioredoxin peroxidase activity	21873635.	IBA	Function
GO:0016480	negative regulation of transcription by RNA polymerase III	10095767.	IDA	Process
GO:0031410	cytoplasmic vesicle	10095767.	IDA	Component
GO:0034599	cellular response to oxidative stress	21873635.	IBA	Process
GO:0034599	cellular response to oxidative stress	-	TAS	Process
GO:0034614	cellular response to reactive oxygen species	18262354.	IMP	Process
GO:0042744	hydrogen peroxide catabolic process	21873635.	IBA	Process
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	18262354.	IMP	Function
GO:0043066	negative regulation of apoptotic process	18262354.	IMP	Process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	-	IEA	Process
GO:0043231	intracellular membrane-bounded organelle	15785239.	IDA	Component
GO:0045454	cell redox homeostasis	21873635.	IBA	Process
GO:0046983	protein dimerization activity	15046979.	IDA	Function
GO:0048471	perinuclear region of cytoplasm	10095767.	IDA	Component
GO:0055114	oxidation-reduction process	-	IEA	Process
GO:0070062	extracellular exosome	19056867.19199708.23533145.	HDA	Component
GO:0098869	cellular oxidant detoxification	-	IEA	Process