EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000126457 (Gene tree)
Gene ID: 3276
Gene Symbol: PRMT1
Alias: HCP1|ANM1|HRMT1L2
Full Name: protein arginine methyltransferase 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 13,244 bases
Position: chr19:49,675,786-49,689,029
Accession: 5187
RBP type: canonical RBP
Summary: This gene encodes a member of the protein arginine N-methyltransferase (PRMT) family. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to terminal guanidino nitrogen atoms. The encoded protein is a type I PRMT and is responsible for the majority of cellular arginine methylation activity. Increased expression of this gene may play a role in many types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2011]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000432349	MTS	PF05175.14	9.9e-05	1	1
ENSP00000432788	MTS	PF05175.14	9.9e-05	1	1
ENSP00000432538	MTS	PF05175.14	0.00017	1	1
ENSP00000431957	MTS	PF05175.14	0.00017	1	1
ENSP00000433480	MTS	PF05175.14	0.00023	1	1
ENSP00000484505	MTS	PF05175.14	0.00031	1	1
ENSP00000433556	MTS	PF05175.14	0.00039	1	1
ENSP00000375724	MTS	PF05175.14	0.00045	1	1
ENSP00000406162	MTS	PF05175.14	0.00048	1	1
ENSP00000432349	Met_10	PF02475.16	0.00062	1	1
ENSP00000432788	Met_10	PF02475.16	0.00062	1	1
ENSP00000432538	Met_10	PF02475.16	0.001	1	1
ENSP00000431957	Met_10	PF02475.16	0.0011	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
27577262	Proteome-wide analysis of arginine monomethylation reveals widespread occurrence in human cells.	Sci Signal	2016 Aug 30	Larsen SC	doi: 10.1126/scisignal.aaf7329.
9029147	A protein-arginine methyltransferase binds to the intracytoplasmic domain of the IFNAR1 chain in the type I interferon receptor.	EMBO J	1997 Jan 15	Abramovich C	-
12183049	Identification of methylated proteins by protein arginine N-methyltransferase 1, PRMT1, with a new expression cloning strategy.	Biochim Biophys Acta	2002 Aug 19	Wada K	-
16492668	Asymmetric arginine dimethylation of heterogeneous nuclear ribonucleoprotein K by protein-arginine methyltransferase 1 inhibits its interaction with c-Src.	J Biol Chem	2006 Apr 21	Ostareck-Lederer A	-
17764653	Arginine methylation of Sam68 and SLM proteins negatively regulates their poly(U) RNA binding activity.	Arch Biochem Biophys	2007 Oct 1	Rho J	-
21464899	The Ccr4-Not complex interacts with the mRNA export machinery.	PLoS One	2011 Mar 28	Kerr SC	doi: 10.1371/journal.pone.0018302.
26020839	Arginine methylation of hnRNPUL1 regulates interaction with NBS1 and recruitment to sites of DNA damage.	Sci Rep	2015 May 28	Gurunathan G	doi: 10.1038/srep10475.
28733251	RNA binding protein RALY promotes Protein Arginine Methyltransferase 1 alternatively spliced isoform v2 relative expression and metastatic potential in breast cancer cells.	Int J Biochem Cell Biol	2017 Oct	Bondy-Chorney E	doi: 10.1016/j.biocel.2017.07.008
28972166	Histone arginine demethylase JMJD6 is linked to stress granule assembly through demethylation of the stress granule-nucleating protein G3BP1.	J Biol Chem	2017 Nov 17	Tsai WC	doi: 10.1074/jbc.M117.800706
29456659	PRMT1-RBM15 axis regulates megakaryocytic differentiation of human umbilical cord blood CD34+ cells.	Exp Ther Med	2018 Mar	Jin S	doi: 10.3892/etm.2018.5693
30321814	PRMT1 Deficiency in Mouse Juvenile Heart Induces Dilated Cardiomyopathy and Reveals Cryptic Alternative Splicing Products.	iScience	2018 Oct 26	Murata K	doi: 10.1016/j.isci.2018.09.023
30354839	The hnRNP raly regulates PRMT1 expression and interacts with the ALS-linked protein FUS: implication for reciprocal cellular localization.	Mol Biol Cell	2018 Oct 24:mbcE18020108	Gasperini L	doi: 10.1091/mbc.E18-02-0108
15525597	Estrogen response element-dependent regulation of transcriptional activation of estrogen receptors alpha and beta by coactivators and corepressors.	J Mol Endocrinol	2004 Oct	Klinge CM	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000534465	PRMT1-219	779	-	ENSP00000431957	207 (aa)	-	E9PIX6
ENST00000527412	PRMT1-208	463	-	-	- (aa)	-	-
ENST00000527866	PRMT1-209	968	-	-	- (aa)	-	-
ENST00000530070	PRMT1-215	525	-	-	- (aa)	-	-
ENST00000525915	PRMT1-205	298	-	-	- (aa)	-	-
ENST00000534676	PRMT1-220	915	-	-	- (aa)	-	-
ENST00000525616	PRMT1-204	780	-	-	- (aa)	-	-
ENST00000529284	PRMT1-212	1182	-	ENSP00000432349	160 (aa)	-	E9PNR9
ENST00000524771	PRMT1-203	713	-	ENSP00000433480	238 (aa)	-	H0YDE4
ENST00000527382	PRMT1-207	699	-	ENSP00000432538	205 (aa)	-	E9PQ98
ENST00000530361	PRMT1-216	866	-	-	- (aa)	-	-
ENST00000526224	PRMT1-206	578	-	ENSP00000432788	160 (aa)	-	E9PNR9
ENST00000610806	PRMT1-221	1192	-	ENSP00000484505	285 (aa)	-	Q99873
ENST00000534280	PRMT1-218	766	-	ENSP00000432050	54 (aa)	-	E9PIE2
ENST00000529650	PRMT1-213	479	-	-	- (aa)	-	-
ENST00000528623	PRMT1-211	543	-	ENSP00000434911	63 (aa)	-	E9PMZ2
ENST00000454376	PRMT1-202	1327	-	ENSP00000406162	371 (aa)	-	Q99873
ENST00000532489	PRMT1-217	1686	XM_005258842	ENSP00000433556	325 (aa)	XP_005258899	E9PKG1
ENST00000529836	PRMT1-214	580	-	ENSP00000437273	110 (aa)	-	E9PMW9
ENST00000391851	PRMT1-201	1393	-	ENSP00000375724	353 (aa)	-	Q99873
ENST00000528126	PRMT1-210	642	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000126457's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04068	FoxO signaling pathway	KEGG
hsa04922	Glucagon signaling pathway	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000126457's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000126457	PRMT1	99	46.835	ENSG00000142453	CARM1	61	40.758

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000126457	PRMT1	100	97.538	ENSACAG00000004864	PRMT1	99	95.393	Anolis_carolinensis
ENSG00000126457	PRMT1	100	100.000	ENSANAG00000021704	PRMT1	100	100.000	Aotus_nancymaae
ENSG00000126457	PRMT1	96	90.997	ENSAMXG00000010374	prmt1	98	90.997	Astyanax_mexicanus
ENSG00000126457	PRMT1	100	100.000	ENSBTAG00000006646	PRMT1	99	100.000	Bos_taurus
ENSG00000126457	PRMT1	100	100.000	ENSCJAG00000003670	PRMT1	100	100.000	Callithrix_jacchus
ENSG00000126457	PRMT1	100	100.000	ENSCAFG00000003589	PRMT1	100	100.000	Canis_familiaris
ENSG00000126457	PRMT1	100	100.000	ENSCAFG00020024443	PRMT1	100	100.000	Canis_lupus_dingo
ENSG00000126457	PRMT1	100	100.000	ENSCHIG00000014997	PRMT1	100	100.000	Capra_hircus
ENSG00000126457	PRMT1	100	100.000	ENSTSYG00000034577	PRMT1	100	100.000	Carlito_syrichta
ENSG00000126457	PRMT1	100	100.000	ENSCAPG00000015596	-	100	100.000	Cavia_aperea
ENSG00000126457	PRMT1	100	100.000	ENSCPOG00000019328	PRMT1	100	100.000	Cavia_porcellus
ENSG00000126457	PRMT1	100	100.000	ENSCCAG00000036122	-	100	100.000	Cebus_capucinus
ENSG00000126457	PRMT1	100	100.000	ENSCATG00000041012	PRMT1	100	100.000	Cercocebus_atys
ENSG00000126457	PRMT1	100	100.000	ENSCLAG00000003806	PRMT1	100	100.000	Chinchilla_lanigera
ENSG00000126457	PRMT1	94	100.000	ENSCSAG00000002474	-	100	100.000	Chlorocebus_sabaeus
ENSG00000126457	PRMT1	100	97.585	ENSCPBG00000006644	PRMT1	84	95.760	Chrysemys_picta_bellii
ENSG00000126457	PRMT1	63	82.609	ENSCING00000015009	-	100	82.500	Ciona_intestinalis
ENSG00000126457	PRMT1	100	100.000	ENSCANG00000034725	PRMT1	100	100.000	Colobus_angolensis_palliatus
ENSG00000126457	PRMT1	100	100.000	ENSCGRG00001018188	Prmt1	100	99.150	Cricetulus_griseus_chok1gshd
ENSG00000126457	PRMT1	100	100.000	ENSCGRG00000014747	Prmt1	100	99.150	Cricetulus_griseus_crigri
ENSG00000126457	PRMT1	100	95.169	ENSCSEG00000011717	prmt1	96	91.176	Cynoglossus_semilaevis
ENSG00000126457	PRMT1	100	96.250	ENSDARG00000010246	prmt1	85	91.509	Danio_rerio
ENSG00000126457	PRMT1	100	100.000	ENSDORG00000014923	Prmt1	100	100.000	Dipodomys_ordii
ENSG00000126457	PRMT1	84	100.000	ENSETEG00000007396	PRMT1	99	78.212	Echinops_telfairi
ENSG00000126457	PRMT1	100	100.000	ENSEASG00005005297	PRMT1	100	100.000	Equus_asinus_asinus
ENSG00000126457	PRMT1	100	100.000	ENSECAG00000024076	PRMT1	99	99.419	Equus_caballus
ENSG00000126457	PRMT1	100	100.000	ENSFCAG00000006081	PRMT1	100	100.000	Felis_catus
ENSG00000126457	PRMT1	100	98.246	ENSFCAG00000031034	-	100	98.305	Felis_catus
ENSG00000126457	PRMT1	100	100.000	ENSFDAG00000017624	-	100	99.730	Fukomys_damarensis
ENSG00000126457	PRMT1	100	97.585	ENSGAGG00000006576	PRMT1	97	94.774	Gopherus_agassizii
ENSG00000126457	PRMT1	100	100.000	ENSGGOG00000000503	PRMT1	100	100.000	Gorilla_gorilla
ENSG00000126457	PRMT1	100	100.000	ENSHGLG00000006326	PRMT1	100	99.730	Heterocephalus_glaber_female
ENSG00000126457	PRMT1	100	100.000	ENSHGLG00100008015	PRMT1	100	99.730	Heterocephalus_glaber_male
ENSG00000126457	PRMT1	100	100.000	ENSSTOG00000025543	PRMT1	100	100.000	Ictidomys_tridecemlineatus
ENSG00000126457	PRMT1	100	100.000	ENSJJAG00000018374	Prmt1	100	99.717	Jaculus_jaculus
ENSG00000126457	PRMT1	100	100.000	ENSLAFG00000018053	PRMT1	100	99.730	Loxodonta_africana
ENSG00000126457	PRMT1	100	100.000	ENSMFAG00000043429	PRMT1	100	100.000	Macaca_fascicularis
ENSG00000126457	PRMT1	100	100.000	ENSMMUG00000003029	-	100	100.000	Macaca_mulatta
ENSG00000126457	PRMT1	100	100.000	ENSMNEG00000007881	PRMT1	100	100.000	Macaca_nemestrina
ENSG00000126457	PRMT1	100	100.000	ENSMLEG00000042235	PRMT1	100	100.000	Mandrillus_leucophaeus
ENSG00000126457	PRMT1	100	100.000	ENSMAUG00000005917	Prmt1	100	98.922	Mesocricetus_auratus
ENSG00000126457	PRMT1	100	100.000	ENSMICG00000030079	PRMT1	100	100.000	Microcebus_murinus
ENSG00000126457	PRMT1	100	96.140	ENSMOCG00000019441	-	100	96.694	Microtus_ochrogaster
ENSG00000126457	PRMT1	100	98.551	ENSMODG00000013595	PRMT1	99	97.443	Monodelphis_domestica
ENSG00000126457	PRMT1	100	99.517	MGP_CAROLIEiJ_G0029687	-	100	99.433	Mus_caroli
ENSG00000126457	PRMT1	100	99.517	MGP_CAROLIEiJ_G0029686	-	100	99.461	Mus_caroli
ENSG00000126457	PRMT1	100	100.000	ENSMUSG00000109324	Prmt1	100	100.000	Mus_musculus
ENSG00000126457	PRMT1	100	100.000	MGP_PahariEiJ_G0012912	-	100	99.717	Mus_pahari
ENSG00000126457	PRMT1	100	100.000	MGP_PahariEiJ_G0012911	-	100	99.730	Mus_pahari
ENSG00000126457	PRMT1	100	100.000	MGP_SPRETEiJ_G0030785	-	100	99.717	Mus_spretus
ENSG00000126457	PRMT1	100	100.000	MGP_SPRETEiJ_G0030784	-	100	99.730	Mus_spretus
ENSG00000126457	PRMT1	95	99.026	ENSMLUG00000026704	-	100	99.026	Myotis_lucifugus
ENSG00000126457	PRMT1	100	100.000	ENSMLUG00000017092	-	100	99.723	Myotis_lucifugus
ENSG00000126457	PRMT1	100	100.000	ENSNGAG00000018656	Prmt1	100	99.717	Nannospalax_galili
ENSG00000126457	PRMT1	100	100.000	ENSNLEG00000005306	-	100	72.507	Nomascus_leucogenys
ENSG00000126457	PRMT1	100	99.692	ENSOPRG00000002011	-	100	99.707	Ochotona_princeps
ENSG00000126457	PRMT1	100	100.000	ENSODEG00000016694	-	100	99.443	Octodon_degus
ENSG00000126457	PRMT1	93	93.137	ENSORLG00000017181	prmt1	95	91.083	Oryzias_latipes
ENSG00000126457	PRMT1	93	93.137	ENSORLG00020018168	prmt1	95	91.083	Oryzias_latipes_hni
ENSG00000126457	PRMT1	100	95.000	ENSOMEG00000012874	prmt1	100	91.077	Oryzias_melastigma
ENSG00000126457	PRMT1	100	100.000	ENSOGAG00000011938	-	100	99.717	Otolemur_garnettii
ENSG00000126457	PRMT1	100	100.000	ENSOARG00000013381	-	86	99.336	Ovis_aries
ENSG00000126457	PRMT1	100	100.000	ENSPPAG00000034989	PRMT1	100	100.000	Pan_paniscus
ENSG00000126457	PRMT1	100	100.000	ENSPPRG00000007371	PRMT1	100	100.000	Panthera_pardus
ENSG00000126457	PRMT1	100	100.000	ENSPTIG00000019080	PRMT1	100	81.941	Panthera_tigris_altaica
ENSG00000126457	PRMT1	100	100.000	ENSPTRG00000040282	PRMT1	100	100.000	Pan_troglodytes
ENSG00000126457	PRMT1	100	95.625	ENSPKIG00000006428	PRMT1	100	86.000	Paramormyrops_kingsleyae
ENSG00000126457	PRMT1	100	100.000	ENSPEMG00000014287	Prmt1	100	99.433	Peromyscus_maniculatus_bairdii
ENSG00000126457	PRMT1	97	98.065	ENSPCIG00000007372	PRMT1	100	93.182	Phascolarctos_cinereus
ENSG00000126457	PRMT1	100	100.000	ENSPCOG00000013819	-	100	100.000	Propithecus_coquereli
ENSG00000126457	PRMT1	100	95.000	ENSPNAG00000018063	prmt1	98	90.671	Pygocentrus_nattereri
ENSG00000126457	PRMT1	100	100.000	ENSRNOG00000004090	LOC100361025	100	99.433	Rattus_norvegicus
ENSG00000126457	PRMT1	100	100.000	ENSRNOG00000026109	Prmt1	100	99.717	Rattus_norvegicus
ENSG00000126457	PRMT1	100	100.000	ENSRBIG00000037391	PRMT1	100	100.000	Rhinopithecus_bieti
ENSG00000126457	PRMT1	100	100.000	ENSRROG00000039426	PRMT1	100	100.000	Rhinopithecus_roxellana
ENSG00000126457	PRMT1	100	100.000	ENSSBOG00000021030	PRMT1	100	99.730	Saimiri_boliviensis_boliviensis
ENSG00000126457	PRMT1	100	93.125	ENSSFOG00015021136	prmt1	98	87.296	Scleropages_formosus
ENSG00000126457	PRMT1	100	96.250	ENSSFOG00015005748	prmt1	98	90.379	Scleropages_formosus
ENSG00000126457	PRMT1	100	100.000	ENSTTRG00000005537	-	100	99.722	Tursiops_truncatus
ENSG00000126457	PRMT1	100	100.000	ENSUAMG00000007446	PRMT1	100	100.000	Ursus_americanus
ENSG00000126457	PRMT1	100	100.000	ENSUMAG00000002599	PRMT1	81	100.000	Ursus_maritimus
ENSG00000126457	PRMT1	100	100.000	ENSVVUG00000021435	PRMT1	100	100.000	Vulpes_vulpes
ENSG00000126457	PRMT1	100	98.068	ENSXETG00000002877	prmt1	100	94.986	Xenopus_tropicalis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001701	in utero embryonic development	-	IEA	Process
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0005515	protein binding	8663146.10749851.15084609.16051612.16169070.16879614.17053781.19095693.19101556.19124016.19858291.21085121.22190034.23455924.23912080.24726341.25284789.25416956.26575292.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	10749851.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	26876602.	IDA	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0006355	regulation of transcription, DNA-templated	21873635.	IBA	Process
GO:0006479	protein methylation	26876602.28040436.	IMP	Process
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	-	TAS	Process
GO:0007166	cell surface receptor signaling pathway	9029147.	TAS	Process
GO:0008168	methyltransferase activity	9545638.	TAS	Function
GO:0008170	N-methyltransferase activity	18657504.	IDA	Function
GO:0008170	N-methyltransferase activity	19124016.	IMP	Function
GO:0008276	protein methyltransferase activity	19460357.	IDA	Function
GO:0008276	protein methyltransferase activity	28040436.	IMP	Function
GO:0008284	positive regulation of cell proliferation	28040436.	IMP	Process
GO:0008327	methyl-CpG binding	25284789.	IDA	Function
GO:0008469	histone-arginine N-methyltransferase activity	21873635.	IBA	Function
GO:0016274	protein-arginine N-methyltransferase activity	18316480.	EXP	Function
GO:0016274	protein-arginine N-methyltransferase activity	18495660.	IDA	Function
GO:0016274	protein-arginine N-methyltransferase activity	-	TAS	Function
GO:0016571	histone methylation	19405910.	IDA	Process
GO:0018216	peptidyl-arginine methylation	18657504.19460357.26575292.	IDA	Process
GO:0019899	enzyme binding	19460357.	IPI	Function
GO:0019919	peptidyl-arginine methylation, to asymmetrical-dimethyl arginine	21873635.	IBA	Process
GO:0031175	neuron projection development	18773938.	IMP	Process
GO:0034709	methylosome	25284789.	IDA	Component
GO:0034969	histone arginine methylation	21873635.	IBA	Process
GO:0035241	protein-arginine omega-N monomethyltransferase activity	26575292.	IDA	Function
GO:0035242	protein-arginine omega-N asymmetric methyltransferase activity	21873635.	IBA	Function
GO:0035242	protein-arginine omega-N asymmetric methyltransferase activity	26575292.	IDA	Function
GO:0035242	protein-arginine omega-N asymmetric methyltransferase activity	25284789.	IMP	Function
GO:0042054	histone methyltransferase activity	19405910.	IDA	Function
GO:0042802	identical protein binding	26876602.	IDA	Function
GO:0042802	identical protein binding	16169070.23455924.25416956.	IPI	Function
GO:0043985	histone H4-R3 methylation	21873635.	IBA	Process
GO:0043985	histone H4-R3 methylation	11448779.	IDA	Process
GO:0044020	histone methyltransferase activity (H4-R3 specific)	11448779.	IDA	Function
GO:0044020	histone methyltransferase activity (H4-R3 specific)	25284789.	IMP	Function
GO:0045648	positive regulation of erythrocyte differentiation	23483889.	IMP	Process
GO:0045652	regulation of megakaryocyte differentiation	26575292.	IDA	Process
GO:0045652	regulation of megakaryocyte differentiation	-	TAS	Process
GO:0045653	negative regulation of megakaryocyte differentiation	20442406.	IDA	Process
GO:0046985	positive regulation of hemoglobin biosynthetic process	-	ISS	Process
GO:0048273	mitogen-activated protein kinase p38 binding	23483889.	IPI	Function
GO:0051260	protein homooligomerization	26876602.	IDA	Process
GO:1900745	positive regulation of p38MAPK cascade	-	ISS	Process
GO:1904047	S-adenosyl-L-methionine binding	26876602.	IDA	Function

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
24211191	CARM1 and PRMT1 are dysregulated in lung cancer without hierarchical features.	Biochimie	2014 Feb	Elakoum R	doi: 10.1016/j.biochi.2013.10.021
27175582	PRMT1 regulates tumor growth and metastasis of human melanoma via targeting ALCAM.	Mol Med Rep	2016 Jul	Li L	doi: 10.3892/mmr.2016.5273
29097184	Protein arginine methyltransferase 1 coordinates the epithelial-mesenchymal transition/proliferation dichotomy in gastric cancer cells.	Exp Cell Res	2018 Jan 1	Zhang Y	doi: 10.1016/j.yexcr.2017.10.035
19078953	The PRMT1 gene expression pattern in colon cancer.	Br J Cancer	2008 Dec 16	Mathioudaki K	doi: 10.1038/sj.bjc.6604807.
17891136	Protein arginine-methyltransferase-dependent oncogenesis.	Nat Cell Biol	2007 Oct	Cheung N	-
19414388	Colon cancer and protein arginine methyltransferase 1 gene expression.	Anticancer Res	2009 Apr	Papadokostopoulou A	-
17848568	Alternative splicing yields protein arginine methyltransferase 1 isoforms with distinct activity, substrate specificity, and subcellular localization.	J Biol Chem	2007 Nov 9	Goulet I	-
20473859	Dysregulation of PRMT1 and PRMT6, Type I arginine methyltransferases, is involved in various types of human cancers.	Int J Cancer	2011 Feb 1	Yoshimatsu M	doi: 10.1002/ijc.25366.
25847239	PRMT1 Is a Novel Regulator of Epithelial-Mesenchymal-Transition in Non-small Cell Lung Cancer.	J Biol Chem	2015 May 22	Avasarala S	doi: 10.1074/jbc.M114.636050
26472729	Nuclear PRMT1 expression is associated with poor prognosis and chemosensitivity in gastric cancer patients.	Gastric Cancer	2016 Jul	Altan B	doi: 10.1007/s10120-015-0551-7
28040436	FAM98A associates with DDX1-C14orf166-FAM98B in a novel complex involved in colorectal cancer progression.	Int J Biochem Cell Biol	2017 Mar	Akter KA	doi: 10.1016/j.biocel.2016.12.013
28733251	RNA binding protein RALY promotes Protein Arginine Methyltransferase 1 alternatively spliced isoform v2 relative expression and metastatic potential in breast cancer cells.	Int J Biochem Cell Biol	2017 Oct	Bondy-Chorney E	doi: 10.1016/j.biocel.2017.07.008
28987382	Arginine methyltransferase inhibitor 1 inhibits gastric cancer by downregulating eIF4E and targeting PRMT5.	Toxicol Appl Pharmacol	2017 Dec 1	Zhang B	doi: 10.1016/j.taap.2017.10.002
26934120	Protein arginine methyltransferase 1 may be involved in pregnane x receptor-activated overexpression of multidrug resistance 1 gene during acquired multidrug resistant.	Oncotarget	2016 Apr 12	Li T	doi: 10.18632/oncotarget.7752.
28656289	PRMT1 expression is elevated in head and neck cancer and inhibition of protein arginine methylation by adenosine dialdehyde or PRMT1 knockdown downregulates proliferation and migration of oral cancer cells.	Oncol Rep	2017 Aug	Chuang CY	doi: 10.3892/or.2017.5737
28643125	The role of PRMT1 in EGFR methylation and signaling in MDA-MB-468 triple-negative breast cancer cells.	Breast Cancer	2018 Jan	Nakai K	doi: 10.1007/s12282-017-0790-z
30569144	Downregulation of PRMT1, a histone arginine methyltransferase, by sodium propionate induces cell apoptosis in colon cancer.	Oncol Rep	2019 Mar	Ryu TY	doi: 10.3892/or.2018.6938

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr19	49688354	3'UTR	novel		0.23
BLCA	chr19	49680251	Intron	novel		0.15
BLCA	chr19	49680586	Missense_Mutation	novel	E64K	0.08	MTS
BLCA	chr19	49682023	Silent	novel	L102L	0.11
BLCA	chr19	49688301	3'UTR	novel		0.48
BLCA	chr19	49681915	Missense_Mutation	novel	M66I	0.22	MTS
BLCA	chr19	49686669	Silent	NA	V325V	0.26
BRCA	chr19	49677280	5'UTR	novel		0.21
BRCA	chr19	49680504	Silent	rs369225266	A36A	0.09
BRCA	chr19	49686098	Silent	rs372428631	V255V	0.13
CESC	chr19	49684760	Missense_Mutation	rs544334510	D188N	0.5
CESC	chr19	49682258	Splice_Region	rs368792906	H137H	0.26
COAD	chr19	49684782	Missense_Mutation	NA	R195Q	0.18
COAD	chr19	49686229	Missense_Mutation	NA	T299I	0.33
COAD	chr19	49682032	Silent	NA	F105F	0.46
COAD	chr19	49684050	Missense_Mutation	NA	Y179C	0.3
COAD	chr19	49688285	3'UTR	rs370187140		0.21
COAD	chr19	49682002	Silent	rs765168424	V95V	0.21
DLBC	chr19	49677265	5'Flank	novel		0.53
ESCA	chr19	49682007	Missense_Mutation	rs750309006	S97L	0.16	MTS
ESCA	chr19	49677288	Missense_Mutation	NA	A3V	0.05
GBM	chr19	49683971	Missense_Mutation	novel	V153L	0.07
GBM	chr19	49681924	Silent	rs746258178	D69D	0.32
HNSC	chr19	49684925	Nonsense_Mutation	novel	W216*	0.2
HNSC	chr19	49681954	Silent	novel	S79S	0.09
HNSC	chr19	49682000	Missense_Mutation	novel	V95I	0.11	MTS
KIRC	chr19	49682062	Silent	rs143554083	I115I	0.52
KIRP	chr19	49682064	Missense_Mutation	novel	G116E	0.46	MTS
LAML	chr19	49688269	3'UTR	rs780187866		0.15
LGG	chr19	49682007	Missense_Mutation	rs750309006	S97L	0.1	MTS
LIHC	chr19	49688309	3'UTR	novel		0.65
LIHC	chr19	49684015	Nonsense_Mutation	NA	C167*	0.27
LIHC	chr19	49677313	Missense_Mutation	NA	M11I	0.25
LUAD	chr19	49681934	Missense_Mutation	novel	T73A	0.14	MTS
LUAD	chr19	49686624	Silent	NA	T310T	0.46
LUAD	chr19	49686093	Missense_Mutation	novel	E254Q	0.22
LUAD	chr19	49684980	Silent	NA	E234E	0.19
LUSC	chr19	49677312	Missense_Mutation	novel	M11T	0.31
LUSC	chr19	49681978	Silent	NA	F87F	0.08
LUSC	chr19	49683962	Missense_Mutation	novel	E150K	0.11
MESO	chr19	49682041	Silent	novel	K108K	0.3
OV	chr19	49680587	Missense_Mutation	novel	E64V	0.07	MTS
OV	chr19	49686639	Silent	rs181508065	T315T	0.16
OV	chr19	49681993	Silent	novel	V92V	0.17
PAAD	chr19	49688316	3'UTR	novel		0.25
PCPG	chr19	49686676	Missense_Mutation	novel	G328C	0.5
PRAD	chr19	49677253	5'Flank	novel		0.24
PRAD	chr19	49688162	Missense_Mutation	novel	R345W	0.33
READ	chr19	49688301	3'UTR	novel		0.45
SKCM	chr19	49681997	Missense_Mutation	novel	D94N	0.41	MTS
SKCM	chr19	49686142	Missense_Mutation	NA	P270R	0.45
SKCM	chr19	49684837	Silent	NA	I213I	0.31
SKCM	chr19	49686616	Missense_Mutation	NA	P308S	0.24
SKCM	chr19	49686142	Missense_Mutation	NA	P270L	0.33
SKCM	chr19	49683988	Silent	NA	I158I	0.35
SKCM	chr19	49677301	Silent	rs543913812	A7A	0.39
SKCM	chr19	49679886	Silent	novel	T17T	0.32
SKCM	chr19	49688315	3'UTR	novel		0.9
STAD	chr19	49688286	3'UTR	rs780998634		0.31
STAD	chr19	49686702	Silent	NA	G336G	0.08
STAD	chr19	49688301	3'UTR	novel		0.28
STAD	chr19	49688359	3'UTR	novel		0.31
STAD	chr19	49686639	Silent	rs181508065	T315T	0.33
STAD	chr19	49688228	Missense_Mutation	NA	D367N	0.16
STAD	chr19	49688189	Missense_Mutation	NA	D354H	0.41
STAD	chr19	49681924	Silent	rs746258178	D69D	0.24
STAD	chr19	49688243	Nonstop_Mutation	NA	372Rext16	0.37
STAD	chr19	49684997	Missense_Mutation	NA	V240A	0.27
STAD	chr19	49686162	Missense_Mutation	rs765879950	R277W	0.2
STAD	chr19	49679912	Missense_Mutation	NA	P26L	0.31
STAD	chr19	49686230	Silent	rs188991153	T299T	0.14
STAD	chr19	49688212	Missense_Mutation	rs769054141	E361D	0.22
THCA	chr19	49677298	Silent	rs576649607	A6A	0.38
UCEC	chr19	49688259	3'UTR	rs760514858		0.19
UCEC	chr19	49679923	Nonsense_Mutation	novel	E30*	0.49
UCEC	chr19	49684944	Silent	rs541813182	F222F	0.52
UCEC	chr19	49685120	Intron	novel		0.43
UCEC	chr19	49680564	Silent	novel	S56S	0.11
UCEC	chr19	49679925	Missense_Mutation	novel	E30D	0.36
UCEC	chr19	49679923	Nonsense_Mutation	novel	E30*	0.27
UCEC	chr19	49680155	Intron	novel		0.04
UCEC	chr19	49684944	Silent	rs541813182	F222F	0.16
UCEC	chr19	49686679	Missense_Mutation	NA	E329K	0.17
UCEC	chr19	49688221	Silent	novel	C364C	0.46
UCEC	chr19	49680235	Intron	novel		0.51
UCEC	chr19	49685023	Missense_Mutation	novel	A249T	0.45
UCEC	chr19	49686714	Silent	rs371303762	N340N	0.18
UCEC	chr19	49680190	Intron	novel		0.24
UCEC	chr19	49677265	5'Flank	novel		0.35
UCEC	chr19	49684963	Missense_Mutation	novel	D229Y	0.51
UCEC	chr19	49680160	Intron	novel		0.4
UCEC	chr19	49688269	3'UTR	rs780187866		0.47
UCEC	chr19	49684936	Missense_Mutation	NA	Y220N	0.36
UCEC	chr19	49686105	Missense_Mutation	novel	Y258H	0.58
UCEC	chr19	49684951	Missense_Mutation	novel	S225A	0.31
UCEC	chr19	49686180	Missense_Mutation	novel	A283T	0.34
UCEC	chr19	49686104	Missense_Mutation	NA	I257M	0.39
UCEC	chr19	49688337	3'UTR	novel		0.3
UCEC	chr19	49686624	Silent	NA	T310T	0.31
UCEC	chr19	49686715	Missense_Mutation	NA	A341T	0.39
UCEC	chr19	49682015	Missense_Mutation	novel	G100S	0.44	MTS
UCEC	chr19	49684995	Silent	novel	V239V	0.26
UCEC	chr19	49686179	Silent	rs376253057	H282H	0.25
UCEC	chr19	49686639	Silent	rs181508065	T315T	0.33
UCEC	chr19	49684963	Missense_Mutation	novel	D229Y	0.37
UCEC	chr19	49681931	Missense_Mutation	novel	R72C	0.52	MTS
UCEC	chr19	49688241	Missense_Mutation	NA	R371H	0.3
UCEC	chr19	49686214	Missense_Mutation	novel	R294H	0.41
UCEC	chr19	49679877	Silent	novel	F14F	0.33
UCEC	chr19	49686162	Missense_Mutation	rs765879950	R277W	0.39
UCEC	chr19	49688240	Missense_Mutation	rs762680335	R371C	0.42

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	DEL	0.0881	0.027508
KIRP	DEL	0.0486	0.054726
LUAD	DEL	0.2539	1.5526e-05
LUSC	DEL	0.2116	1.1877e-06
PAAD	DEL	0.0815	0.035089
READ	DEL	0.0909	0.23023
TGCT	DEL	0.2867	0.0046229
UCS	DEL	0.1786	0.12448

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
SARC	0.0034	Kaplan-Meier Survival Analysis
MESO	0.00021	Kaplan-Meier Survival Analysis
ACC	0.014	Kaplan-Meier Survival Analysis
SKCM	0.0034	Kaplan-Meier Survival Analysis
ESCA	0.035	Kaplan-Meier Survival Analysis
KIRP	0.027	Kaplan-Meier Survival Analysis
PCPG	0.04	Kaplan-Meier Survival Analysis
LIHC	0.00045	Kaplan-Meier Survival Analysis
LGG	0.019	Kaplan-Meier Survival Analysis
LUAD	0.0054	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Paralogs

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742