EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000126653 (Gene tree)
Gene ID: 84081
Gene Symbol: NSRP1
Alias: DKFZP434K1421|NSrp70|CCDC55
Full Name: nuclear speckle splicing regulatory protein 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 70,955 bases
Position: chr17:30,115,521-30,186,475
Accession: 25305
RBP type: canonical RBP
Summary: (Nuclear Speckle Splicing Regulatory Protein 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include mRNA binding. An important paralog of this gene is EFCAB5.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000468327	DUF2040	PF09745.9	6.1e-37	1	1
ENSP00000477862	DUF2040	PF09745.9	1.2e-35	1	1
ENSP00000247026	DUF2040	PF09745.9	1.4e-35	1	1
ENSP00000466463	DUF2040	PF09745.9	7.7e-34	1	1
ENSP00000465442	DUF2040	PF09745.9	8e-17	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000581048	NSRP1-209	547	-	-	- (aa)	-	-
ENST00000589608	NSRP1-216	368	-	ENSP00000467856	68 (aa)	-	K7EQJ6
ENST00000467446	NSRP1-203	548	-	-	- (aa)	-	-
ENST00000394826	NSRP1-202	1800	-	ENSP00000378303	50 (aa)	-	H7BYM1
ENST00000475652	NSRP1-204	1242	-	ENSP00000464569	41 (aa)	-	J3QS82
ENST00000588614	NSRP1-215	497	-	ENSP00000466463	104 (aa)	-	K7EMD8
ENST00000612959	NSRP1-217	2420	-	ENSP00000477862	504 (aa)	-	A0A024QZ33
ENST00000585881	NSRP1-214	582	-	ENSP00000465442	64 (aa)	-	K7EK40
ENST00000583301	NSRP1-210	684	-	-	- (aa)	-	-
ENST00000247026	NSRP1-201	2541	XM_011525345	ENSP00000247026	558 (aa)	XP_011523647	Q9H0G5
ENST00000577289	NSRP1-207	562	-	-	- (aa)	-	-
ENST00000584154	NSRP1-211	583	-	ENSP00000462820	42 (aa)	-	J3KT62
ENST00000584317	NSRP1-212	564	-	ENSP00000463722	74 (aa)	-	J3QLV5
ENST00000540900	NSRP1-206	2057	-	-	- (aa)	-	-
ENST00000580103	NSRP1-208	774	-	ENSP00000468327	157 (aa)	-	K7ERM9
ENST00000479218	NSRP1-205	540	-	ENSP00000466640	41 (aa)	-	J3QS82
ENST00000584423	NSRP1-213	482	-	ENSP00000464237	92 (aa)	-	J3QRI6

Gene Model

Click here to download ENSG00000126653's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000126653	Electrocardiography	6E-9	27659466

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000126653	rs7211246	17	30158744	?	QRS complex (12-leadsum)	27659466	[76.66-154.58] unit increase	115.62	EFO_0007742\|EFO_0005054

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000126653's network

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000126653	NSRP1	53	63.889	ENSG00000205339	IPO7	56	63.889
ENSG00000126653	NSRP1	84	61.905	ENSG00000011376	LARS2	60	61.905

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000126653	NSRP1	100	64.062	ENSAPOG00000019041	nsrp1	100	41.711	Acanthochromis_polyacanthus
ENSG00000126653	NSRP1	100	100.000	ENSAMEG00000004028	NSRP1	100	82.184	Ailuropoda_melanoleuca
ENSG00000126653	NSRP1	100	64.062	ENSACIG00000014008	nsrp1	99	41.889	Amphilophus_citrinellus
ENSG00000126653	NSRP1	100	64.062	ENSAOCG00000011727	nsrp1	87	65.238	Amphiprion_ocellaris
ENSG00000126653	NSRP1	99	65.161	ENSAPEG00000018767	nsrp1	99	37.786	Amphiprion_percula
ENSG00000126653	NSRP1	100	62.500	ENSATEG00000006815	nsrp1	100	39.547	Anabas_testudineus
ENSG00000126653	NSRP1	100	84.177	ENSAPLG00000011228	NSRP1	99	52.249	Anas_platyrhynchos
ENSG00000126653	NSRP1	97	79.085	ENSACAG00000011582	NSRP1	99	48.754	Anolis_carolinensis
ENSG00000126653	NSRP1	100	99.038	ENSANAG00000036718	NSRP1	100	93.907	Aotus_nancymaae
ENSG00000126653	NSRP1	100	64.062	ENSACLG00000005604	nsrp1	100	41.208	Astatotilapia_calliptera
ENSG00000126653	NSRP1	100	70.312	ENSAMXG00000038882	nsrp1	100	42.857	Astyanax_mexicanus
ENSG00000126653	NSRP1	100	98.077	ENSBTAG00000019341	NSRP1	100	81.818	Bos_taurus
ENSG00000126653	NSRP1	100	98.077	ENSCJAG00000013710	NSRP1	100	91.935	Callithrix_jacchus
ENSG00000126653	NSRP1	100	98.077	ENSCAFG00000018976	NSRP1	100	82.918	Canis_familiaris
ENSG00000126653	NSRP1	100	98.077	ENSCAFG00020011309	NSRP1	100	82.918	Canis_lupus_dingo
ENSG00000126653	NSRP1	100	98.077	ENSCHIG00000021222	NSRP1	100	81.105	Capra_hircus
ENSG00000126653	NSRP1	100	97.115	ENSTSYG00000030918	NSRP1	100	86.833	Carlito_syrichta
ENSG00000126653	NSRP1	100	96.154	ENSCPOG00000031448	NSRP1	98	80.505	Cavia_porcellus
ENSG00000126653	NSRP1	100	98.089	ENSCCAG00000025135	NSRP1	100	92.659	Cebus_capucinus
ENSG00000126653	NSRP1	100	100.000	ENSCATG00000038363	NSRP1	100	95.878	Cercocebus_atys
ENSG00000126653	NSRP1	90	92.105	ENSCATG00000031727	-	100	72.809	Cercocebus_atys
ENSG00000126653	NSRP1	100	94.904	ENSCLAG00000005413	NSRP1	100	81.038	Chinchilla_lanigera
ENSG00000126653	NSRP1	100	100.000	ENSCSAG00000006841	NSRP1	100	95.878	Chlorocebus_sabaeus
ENSG00000126653	NSRP1	97	85.621	ENSCPBG00000020074	NSRP1	98	56.818	Chrysemys_picta_bellii
ENSG00000126653	NSRP1	98	54.545	ENSCING00000015091	-	51	50.235	Ciona_intestinalis
ENSG00000126653	NSRP1	97	63.077	ENSCSAVG00000011750	-	96	54.774	Ciona_savignyi
ENSG00000126653	NSRP1	100	100.000	ENSCANG00000017067	NSRP1	100	95.341	Colobus_angolensis_palliatus
ENSG00000126653	NSRP1	100	97.115	ENSCGRG00001017048	Nsrp1	100	72.939	Cricetulus_griseus_chok1gshd
ENSG00000126653	NSRP1	100	97.115	ENSCGRG00000010270	Nsrp1	100	72.760	Cricetulus_griseus_crigri
ENSG00000126653	NSRP1	100	64.062	ENSCSEG00000018083	nsrp1	71	45.250	Cynoglossus_semilaevis
ENSG00000126653	NSRP1	100	64.062	ENSCVAG00000021345	nsrp1	99	39.335	Cyprinodon_variegatus
ENSG00000126653	NSRP1	100	68.750	ENSDARG00000015221	nsrp1	100	41.493	Danio_rerio
ENSG00000126653	NSRP1	99	77.848	ENSDNOG00000046565	-	99	59.259	Dasypus_novemcinctus
ENSG00000126653	NSRP1	100	98.077	ENSDNOG00000047758	-	100	80.497	Dasypus_novemcinctus
ENSG00000126653	NSRP1	100	98.077	ENSDNOG00000014737	-	100	81.996	Dasypus_novemcinctus
ENSG00000126653	NSRP1	100	97.115	ENSDORG00000010440	Nsrp1	100	79.144	Dipodomys_ordii
ENSG00000126653	NSRP1	88	46.154	FBgn0030474	CG15747	75	36.000	Drosophila_melanogaster
ENSG00000126653	NSRP1	97	100.000	ENSETEG00000015217	NSRP1	100	71.657	Echinops_telfairi
ENSG00000126653	NSRP1	100	97.115	ENSEASG00005009692	NSRP1	100	85.968	Equus_asinus_asinus
ENSG00000126653	NSRP1	100	97.115	ENSECAG00000017076	NSRP1	100	85.943	Equus_caballus
ENSG00000126653	NSRP1	100	60.938	ENSELUG00000005731	nsrp1	100	39.724	Esox_lucius
ENSG00000126653	NSRP1	100	98.077	ENSFCAG00000039697	NSRP1	100	82.213	Felis_catus
ENSG00000126653	NSRP1	100	81.646	ENSFALG00000006216	NSRP1	98	51.736	Ficedula_albicollis
ENSG00000126653	NSRP1	76	96.875	ENSFDAG00000011177	-	100	94.872	Fukomys_damarensis
ENSG00000126653	NSRP1	100	65.625	ENSFHEG00000004525	nsrp1	100	41.239	Fundulus_heteroclitus
ENSG00000126653	NSRP1	100	62.500	ENSGMOG00000007152	nsrp1	99	62.264	Gadus_morhua
ENSG00000126653	NSRP1	100	84.810	ENSGALG00000004186	NSRP1	100	52.860	Gallus_gallus
ENSG00000126653	NSRP1	97	64.516	ENSGAFG00000000710	nsrp1	100	42.602	Gambusia_affinis
ENSG00000126653	NSRP1	100	64.062	ENSGACG00000020516	nsrp1	99	39.623	Gasterosteus_aculeatus
ENSG00000126653	NSRP1	97	84.967	ENSGAGG00000011536	NSRP1	100	56.080	Gopherus_agassizii
ENSG00000126653	NSRP1	100	100.000	ENSGGOG00000009216	NSRP1	100	98.925	Gorilla_gorilla
ENSG00000126653	NSRP1	100	64.062	ENSHBUG00000021510	nsrp1	97	40.502	Haplochromis_burtoni
ENSG00000126653	NSRP1	71	96.667	ENSHGLG00000016702	-	100	93.590	Heterocephalus_glaber_female
ENSG00000126653	NSRP1	71	96.667	ENSHGLG00100019478	-	100	93.590	Heterocephalus_glaber_male
ENSG00000126653	NSRP1	100	62.500	ENSHCOG00000009930	nsrp1	65	65.829	Hippocampus_comes
ENSG00000126653	NSRP1	100	67.188	ENSIPUG00000019291	nsrp1	99	39.714	Ictalurus_punctatus
ENSG00000126653	NSRP1	100	99.038	ENSSTOG00000028001	NSRP1	100	84.342	Ictidomys_tridecemlineatus
ENSG00000126653	NSRP1	100	97.115	ENSJJAG00000011862	Nsrp1	99	78.995	Jaculus_jaculus
ENSG00000126653	NSRP1	100	68.750	ENSKMAG00000019403	nsrp1	77	46.618	Kryptolebias_marmoratus
ENSG00000126653	NSRP1	88	64.493	ENSLBEG00000027763	nsrp1	86	61.809	Labrus_bergylta
ENSG00000126653	NSRP1	100	79.688	ENSLACG00000014674	NSRP1	100	47.099	Latimeria_chalumnae
ENSG00000126653	NSRP1	93	61.538	ENSLOCG00000006654	nsrp1	62	54.902	Lepisosteus_oculatus
ENSG00000126653	NSRP1	100	99.038	ENSLAFG00000013731	NSRP1	100	69.482	Loxodonta_africana
ENSG00000126653	NSRP1	90	89.474	ENSMFAG00000038296	-	100	69.805	Macaca_fascicularis
ENSG00000126653	NSRP1	100	100.000	ENSMFAG00000014745	NSRP1	100	95.341	Macaca_fascicularis
ENSG00000126653	NSRP1	100	100.000	ENSMMUG00000012121	NSRP1	100	95.040	Macaca_mulatta
ENSG00000126653	NSRP1	100	100.000	ENSMNEG00000039986	NSRP1	100	95.520	Macaca_nemestrina
ENSG00000126653	NSRP1	100	100.000	ENSMLEG00000042611	NSRP1	100	95.161	Mandrillus_leucophaeus
ENSG00000126653	NSRP1	100	65.625	ENSMAMG00000020195	nsrp1	100	39.858	Mastacembelus_armatus
ENSG00000126653	NSRP1	100	64.062	ENSMZEG00005024743	nsrp1	100	41.030	Maylandia_zebra
ENSG00000126653	NSRP1	100	84.810	ENSMGAG00000006240	NSRP1	100	51.736	Meleagris_gallopavo
ENSG00000126653	NSRP1	76	90.625	ENSMAUG00000017652	-	97	96.053	Mesocricetus_auratus
ENSG00000126653	NSRP1	100	98.726	ENSMICG00000006365	NSRP1	100	88.172	Microcebus_murinus
ENSG00000126653	NSRP1	100	97.115	ENSMOCG00000019716	Nsrp1	100	69.713	Microtus_ochrogaster
ENSG00000126653	NSRP1	92	65.972	ENSMMOG00000010908	nsrp1	98	39.643	Mola_mola
ENSG00000126653	NSRP1	100	93.750	ENSMODG00000009868	NSRP1	100	58.201	Monodelphis_domestica
ENSG00000126653	NSRP1	100	62.500	ENSMALG00000018409	nsrp1	99	38.172	Monopterus_albus
ENSG00000126653	NSRP1	100	92.357	MGP_CAROLIEiJ_G0016769	Nsrp1	96	88.158	Mus_caroli
ENSG00000126653	NSRP1	100	95.312	ENSMUSG00000037958	Nsrp1	96	92.105	Mus_musculus
ENSG00000126653	NSRP1	100	96.154	MGP_PahariEiJ_G0017906	Nsrp1	96	92.105	Mus_pahari
ENSG00000126653	NSRP1	100	93.750	MGP_SPRETEiJ_G0017612	-	100	92.718	Mus_spretus
ENSG00000126653	NSRP1	100	99.038	ENSMLUG00000017469	NSRP1	100	83.957	Myotis_lucifugus
ENSG00000126653	NSRP1	76	87.500	ENSNGAG00000000819	-	97	94.737	Nannospalax_galili
ENSG00000126653	NSRP1	100	65.625	ENSNBRG00000009326	nsrp1	62	67.188	Neolamprologus_brichardi
ENSG00000126653	NSRP1	100	99.038	ENSNLEG00000003642	NSRP1	100	97.670	Nomascus_leucogenys
ENSG00000126653	NSRP1	100	92.188	ENSMEUG00000012486	NSRP1	100	58.970	Notamacropus_eugenii
ENSG00000126653	NSRP1	100	96.178	ENSOPRG00000007870	NSRP1	100	74.038	Ochotona_princeps
ENSG00000126653	NSRP1	100	97.115	ENSODEG00000009225	NSRP1	99	79.891	Octodon_degus
ENSG00000126653	NSRP1	100	65.625	ENSONIG00000005565	nsrp1	55	66.834	Oreochromis_niloticus
ENSG00000126653	NSRP1	100	92.188	ENSOANG00000012656	NSRP1	100	58.869	Ornithorhynchus_anatinus
ENSG00000126653	NSRP1	98	96.104	ENSOCUG00000000155	NSRP1	100	81.593	Oryctolagus_cuniculus
ENSG00000126653	NSRP1	100	64.062	ENSORLG00000003135	nsrp1	93	59.184	Oryzias_latipes
ENSG00000126653	NSRP1	100	64.062	ENSORLG00020016065	nsrp1	100	39.894	Oryzias_latipes_hni
ENSG00000126653	NSRP1	100	64.062	ENSORLG00015020804	nsrp1	96	40.399	Oryzias_latipes_hsok
ENSG00000126653	NSRP1	97	81.186	ENSOGAG00000000820	-	100	79.848	Otolemur_garnettii
ENSG00000126653	NSRP1	74	100.000	ENSOGAG00000032682	-	99	70.179	Otolemur_garnettii
ENSG00000126653	NSRP1	100	98.077	ENSOARG00000009006	NSRP1	100	79.924	Ovis_aries
ENSG00000126653	NSRP1	100	100.000	ENSPPAG00000003543	NSRP1	100	99.104	Pan_paniscus
ENSG00000126653	NSRP1	100	98.077	ENSPPRG00000022797	NSRP1	100	83.750	Panthera_pardus
ENSG00000126653	NSRP1	100	98.077	ENSPTIG00000012822	NSRP1	100	83.750	Panthera_tigris_altaica
ENSG00000126653	NSRP1	100	100.000	ENSPTRG00000008957	NSRP1	100	99.283	Pan_troglodytes
ENSG00000126653	NSRP1	100	100.000	ENSPANG00000023146	NSRP1	100	90.681	Papio_anubis
ENSG00000126653	NSRP1	97	65.359	ENSPKIG00000000088	nsrp1	100	41.429	Paramormyrops_kingsleyae
ENSG00000126653	NSRP1	100	82.911	ENSPSIG00000008905	NSRP1	100	54.643	Pelodiscus_sinensis
ENSG00000126653	NSRP1	100	65.625	ENSPMGG00000021712	nsrp1	100	42.504	Periophthalmus_magnuspinnatus
ENSG00000126653	NSRP1	100	98.438	ENSPEMG00000021659	Nsrp1	100	71.556	Peromyscus_maniculatus_bairdii
ENSG00000126653	NSRP1	100	92.188	ENSPCIG00000022736	-	100	53.817	Phascolarctos_cinereus
ENSG00000126653	NSRP1	100	65.625	ENSPFOG00000011548	nsrp1	100	42.531	Poecilia_formosa
ENSG00000126653	NSRP1	100	65.625	ENSPLAG00000005053	nsrp1	80	47.393	Poecilia_latipinna
ENSG00000126653	NSRP1	100	65.625	ENSPMEG00000013288	nsrp1	100	42.246	Poecilia_mexicana
ENSG00000126653	NSRP1	100	65.625	ENSPREG00000009861	nsrp1	100	43.494	Poecilia_reticulata
ENSG00000126653	NSRP1	100	99.363	ENSPPYG00000008130	NSRP1	100	97.312	Pongo_abelii
ENSG00000126653	NSRP1	100	99.038	ENSPCAG00000000515	NSRP1	93	80.880	Procavia_capensis
ENSG00000126653	NSRP1	100	98.726	ENSPCOG00000022352	NSRP1	100	89.964	Propithecus_coquereli
ENSG00000126653	NSRP1	100	98.077	ENSPVAG00000009281	NSRP1	100	83.005	Pteropus_vampyrus
ENSG00000126653	NSRP1	100	64.062	ENSPNYG00000024136	nsrp1	98	37.629	Pundamilia_nyererei
ENSG00000126653	NSRP1	100	67.188	ENSPNAG00000013616	nsrp1	99	42.143	Pygocentrus_nattereri
ENSG00000126653	NSRP1	100	96.154	ENSRNOG00000022502	Nsrp1	100	72.987	Rattus_norvegicus
ENSG00000126653	NSRP1	100	100.000	ENSRBIG00000044358	NSRP1	100	94.633	Rhinopithecus_bieti
ENSG00000126653	NSRP1	100	100.000	ENSRROG00000033310	NSRP1	100	94.812	Rhinopithecus_roxellana
ENSG00000126653	NSRP1	100	97.452	ENSSBOG00000022240	NSRP1	100	92.652	Saimiri_boliviensis_boliviensis
ENSG00000126653	NSRP1	99	90.323	ENSSHAG00000003513	-	100	48.940	Sarcophilus_harrisii
ENSG00000126653	NSRP1	94	70.068	ENSSFOG00015004371	nsrp1	100	41.711	Scleropages_formosus
ENSG00000126653	NSRP1	100	65.625	ENSSMAG00000019880	nsrp1	100	41.476	Scophthalmus_maximus
ENSG00000126653	NSRP1	100	65.625	ENSSDUG00000016675	nsrp1	97	41.802	Seriola_dumerili
ENSG00000126653	NSRP1	100	64.062	ENSSLDG00000014686	nsrp1	97	41.336	Seriola_lalandi_dorsalis
ENSG00000126653	NSRP1	100	84.177	ENSSPUG00000004538	NSRP1	100	51.313	Sphenodon_punctatus
ENSG00000126653	NSRP1	99	65.161	ENSSPAG00000002693	nsrp1	100	42.321	Stegastes_partitus
ENSG00000126653	NSRP1	100	97.115	ENSSSCG00000017795	NSRP1	100	78.243	Sus_scrofa
ENSG00000126653	NSRP1	100	82.911	ENSTGUG00000006486	NSRP1	100	51.215	Taeniopygia_guttata
ENSG00000126653	NSRP1	94	68.027	ENSTRUG00000000226	nsrp1	85	66.834	Takifugu_rubripes
ENSG00000126653	NSRP1	93	66.438	ENSTNIG00000016161	nsrp1	93	59.091	Tetraodon_nigroviridis
ENSG00000126653	NSRP1	90	97.368	ENSTBEG00000003664	-	100	61.964	Tupaia_belangeri
ENSG00000126653	NSRP1	100	89.172	ENSTTRG00000016338	NSRP1	100	81.982	Tursiops_truncatus
ENSG00000126653	NSRP1	98	100.000	ENSUAMG00000019522	NSRP1	99	80.040	Ursus_americanus
ENSG00000126653	NSRP1	100	100.000	ENSUMAG00000010579	NSRP1	100	81.053	Ursus_maritimus
ENSG00000126653	NSRP1	100	97.115	ENSVPAG00000003569	NSRP1	80	96.585	Vicugna_pacos
ENSG00000126653	NSRP1	100	98.077	ENSVVUG00000021161	-	100	82.028	Vulpes_vulpes
ENSG00000126653	NSRP1	100	65.625	ENSXMAG00000029464	nsrp1	100	41.783	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000381	regulation of alternative mRNA splicing, via spliceosome	21296756.	IDA	Process
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0003729	mRNA binding	21296756.	IDA	Function
GO:0005515	protein binding	21296756.	IPI	Function
GO:0005634	nucleus	21296756.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0006397	mRNA processing	-	IEA	Process
GO:0008380	RNA splicing	-	IEA	Process
GO:0016607	nuclear speck	21296756.	IDA	Component
GO:0032502	developmental process	21296756.	IMP	Process
GO:1990904	ribonucleoprotein complex	21296756.	IDA	Component