EuRBPDB

Description

Ensembl ID: ENSG00000126777 (Gene tree)
Gene ID: 3895
Gene Symbol: KTN1
Alias: KIAA0004|CG1|KNT
Full Name: kinectin 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 142,455 bases
Position: chr14:55,559,072-55,701,526
Accession: 6467
RBP type: non-canonical RBP
Summary: This gene encodes an integral membrane protein that is a member of the kinectin protein family. The encoded protein is primarily localized to the endoplasmic reticulum membrane. This protein binds kinesin and may be involved in intracellular organelle motility. This protein also binds translation elongation factor-delta and may be involved in the assembly of the elongation factor-1 complex. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, Aug 2012]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000554294	KTN1-212	564	-	ENSP00000451876	138 (aa)	-	H0YJP2
ENST00000554567	KTN1-215	730	-	ENSP00000452459	14 (aa)	-	G3V5Q0
ENST00000555164	KTN1-219	542	-	-	- (aa)	-	-
ENST00000554507	KTN1-214	2057	-	ENSP00000452073	595 (aa)	-	G3V4Y7
ENST00000395314	KTN1-205	4618	XM_006720138	ENSP00000378725	1357 (aa)	XP_006720201	Q86UP2
ENST00000557267	KTN1-225	291	-	ENSP00000451641	60 (aa)	-	G3V475
ENST00000553624	KTN1-210	731	-	ENSP00000452445	160 (aa)	-	G3V5P0
ENST00000395311	KTN1-204	4516	XM_017021285	ENSP00000378722	1306 (aa)	XP_016876774	Q86UP2
ENST00000555506	KTN1-222	1464	-	-	- (aa)	-	-
ENST00000553360	KTN1-209	993	-	ENSP00000452576	153 (aa)	-	H0YJZ8
ENST00000555573	KTN1-223	1712	-	ENSP00000451698	334 (aa)	-	B7Z6P3
ENST00000554831	KTN1-217	6241	-	-	- (aa)	-	-
ENST00000413890	KTN1-206	4473	XM_011536753	ENSP00000394992	1306 (aa)	XP_011535055	Q86UP2
ENST00000438792	KTN1-207	4449	XM_017021282	ENSP00000391964	1300 (aa)	XP_016876771	Q86UP2
ENST00000556631	KTN1-224	5299	-	-	- (aa)	-	-
ENST00000554890	KTN1-218	588	-	ENSP00000452337	162 (aa)	-	G3V5G2
ENST00000555172	KTN1-220	1985	-	-	- (aa)	-	-
ENST00000395309	KTN1-203	4021	-	ENSP00000378720	1306 (aa)	-	Q86UP2
ENST00000395308	KTN1-202	4134	-	ENSP00000378719	1306 (aa)	-	Q86UP2
ENST00000553710	KTN1-211	255	-	ENSP00000451139	16 (aa)	-	H0YJB7
ENST00000555498	KTN1-221	595	-	ENSP00000451878	75 (aa)	-	G3V4L8
ENST00000459737	KTN1-208	4793	-	ENSP00000432149	1357 (aa)	-	Q86UP2
ENST00000554306	KTN1-213	476	-	-	- (aa)	-	-
ENST00000554570	KTN1-216	521	-	ENSP00000452205	91 (aa)	-	H0YJV5
ENST00000334975	KTN1-201	2485	-	-	- (aa)	-	-

Gene Model

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000126777	Atrial Pressure	1.765e-005	-
ENSG00000126777	Atrial Pressure	3.508e-005	-
ENSG00000126777	Atrial Pressure	6.795e-005	-
ENSG00000126777	Atrial Pressure	1.765e-005	-
ENSG00000126777	Atrial Pressure	3.508e-005	-
ENSG00000126777	Platelet Function Tests	2.7436400E-005	-
ENSG00000126777	Platelet Function Tests	2.7436400E-005	-
ENSG00000126777	Putamen	1E-33	25607358

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000126777	KTN1	100	90.667	ENSMUSG00000021843	Ktn1	100	86.364	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0005515	protein binding	25416956.	IPI	Function
GO:0005783	endoplasmic reticulum	-	IDA	Component
GO:0005788	endoplasmic reticulum lumen	-	TAS	Component
GO:0005789	endoplasmic reticulum membrane	-	TAS	Component
GO:0005887	integral component of plasma membrane	7787243.	TAS	Component
GO:0007018	microtubule-based movement	-	IEA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016021	integral component of membrane	7787244.	TAS	Component
GO:0019894	kinesin binding	-	IEA	Function
GO:0043687	post-translational protein modification	-	TAS	Process
GO:0044267	cellular protein metabolic process	-	TAS	Process
GO:0045296	cadherin binding	25468996.	HDA	Function