EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000126814 (Gene tree)
Gene ID: 57570
Gene Symbol: TRMT5
Alias: TRM5|KIAA1393
Full Name: tRNA methyltransferase 5
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 9,918 bases
Position: chr14:60,971,441-60,981,358
Accession: 23141
RBP type: canonical RBP
Summary: tRNAs contain as many as 13 or 14 nucleotides that are modified posttranscriptionally by enzymes that are highly specific for particular nucleotides in the tRNA structure. TRMT5 methylates the N1 position of guanosine-37 (G37) in selected tRNAs using S-adenosyl methionine (Brule et al., 2004 [PubMed 15248782]).[supplied by OMIM, Mar 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000261249	Met_10	PF02475.16	2.8e-62	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000555420	TRMT5-203	572	-	ENSP00000451666	152 (aa)	-	G3V494
ENST00000553903	TRMT5-202	560	-	ENSP00000452567	169 (aa)	-	G3V5X1
ENST00000261249	TRMT5-201	5573	-	ENSP00000261249	509 (aa)	-	Q32P41

Gene Model

Click here to download ENSG00000126814's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000126814	Body Mass Index	2.23739026471794E-6	17903300

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000126814's network

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000126814	TRMT5	84	56.876	ENSAPOG00000015490	trmt5	98	56.909	Acanthochromis_polyacanthus
ENSG00000126814	TRMT5	100	84.314	ENSAMEG00000002979	TRMT5	100	84.314	Ailuropoda_melanoleuca
ENSG00000126814	TRMT5	84	56.381	ENSACIG00000024216	trmt5	98	56.542	Amphilophus_citrinellus
ENSG00000126814	TRMT5	84	57.343	ENSAOCG00000007757	trmt5	98	57.143	Amphiprion_ocellaris
ENSG00000126814	TRMT5	84	56.977	ENSAPEG00000022718	trmt5	98	57.143	Amphiprion_percula
ENSG00000126814	TRMT5	84	56.643	ENSATEG00000015576	trmt5	87	56.674	Anabas_testudineus
ENSG00000126814	TRMT5	97	62.753	ENSAPLG00000008002	TRMT5	99	62.753	Anas_platyrhynchos
ENSG00000126814	TRMT5	99	59.725	ENSACAG00000006533	TRMT5	99	59.725	Anolis_carolinensis
ENSG00000126814	TRMT5	100	93.320	ENSANAG00000024875	TRMT5	93	93.320	Aotus_nancymaae
ENSG00000126814	TRMT5	80	56.341	ENSACLG00000020216	trmt5	90	51.522	Astatotilapia_calliptera
ENSG00000126814	TRMT5	89	54.194	ENSAMXG00000021299	trmt5	94	54.194	Astyanax_mexicanus
ENSG00000126814	TRMT5	97	84.818	ENSBTAG00000011796	TRMT5	99	84.818	Bos_taurus
ENSG00000126814	TRMT5	79	33.487	WBGene00194707	C53A5.17	91	33.487	Caenorhabditis_elegans
ENSG00000126814	TRMT5	100	93.124	ENSCJAG00000019157	TRMT5	100	93.124	Callithrix_jacchus
ENSG00000126814	TRMT5	99	83.597	ENSCAFG00000015647	TRMT5	99	84.725	Canis_familiaris
ENSG00000126814	TRMT5	96	84.725	ENSCAFG00020008016	TRMT5	99	84.725	Canis_lupus_dingo
ENSG00000126814	TRMT5	97	85.628	ENSCHIG00000018801	TRMT5	100	85.312	Capra_hircus
ENSG00000126814	TRMT5	100	87.819	ENSTSYG00000001043	TRMT5	100	87.819	Carlito_syrichta
ENSG00000126814	TRMT5	99	69.863	ENSCAPG00000014642	TRMT5	100	70.254	Cavia_aperea
ENSG00000126814	TRMT5	99	81.188	ENSCPOG00000014396	TRMT5	100	80.868	Cavia_porcellus
ENSG00000126814	TRMT5	100	93.124	ENSCCAG00000037835	TRMT5	100	93.124	Cebus_capucinus
ENSG00000126814	TRMT5	100	94.499	ENSCATG00000045352	TRMT5	100	94.499	Cercocebus_atys
ENSG00000126814	TRMT5	94	84.551	ENSCLAG00000013155	TRMT5	99	84.551	Chinchilla_lanigera
ENSG00000126814	TRMT5	100	94.499	ENSCSAG00000014159	TRMT5	91	94.499	Chlorocebus_sabaeus
ENSG00000126814	TRMT5	78	86.146	ENSCHOG00000008128	-	100	86.146	Choloepus_hoffmanni
ENSG00000126814	TRMT5	98	64.729	ENSCPBG00000022359	TRMT5	98	64.729	Chrysemys_picta_bellii
ENSG00000126814	TRMT5	82	43.311	ENSCING00000018970	-	99	43.311	Ciona_intestinalis
ENSG00000126814	TRMT5	85	40.798	ENSCSAVG00000000418	-	95	41.256	Ciona_savignyi
ENSG00000126814	TRMT5	100	95.285	ENSCANG00000032648	TRMT5	100	95.285	Colobus_angolensis_palliatus
ENSG00000126814	TRMT5	99	77.822	ENSCGRG00001018337	TRMT5	100	81.778	Cricetulus_griseus_chok1gshd
ENSG00000126814	TRMT5	99	77.822	ENSCGRG00000010454	Trmt5	99	77.822	Cricetulus_griseus_crigri
ENSG00000126814	TRMT5	84	57.541	ENSCSEG00000001533	trmt5	90	57.710	Cynoglossus_semilaevis
ENSG00000126814	TRMT5	85	55.172	ENSCVAG00000007630	trmt5	98	55.269	Cyprinodon_variegatus
ENSG00000126814	TRMT5	85	58.108	ENSDARG00000069278	trmt5	90	59.080	Danio_rerio
ENSG00000126814	TRMT5	99	83.300	ENSDNOG00000019211	TRMT5	97	83.300	Dasypus_novemcinctus
ENSG00000126814	TRMT5	98	84.168	ENSDORG00000015555	Trmt5	100	84.168	Dipodomys_ordii
ENSG00000126814	TRMT5	79	44.988	FBgn0052281	CG32281	88	44.988	Drosophila_melanogaster
ENSG00000126814	TRMT5	87	81.864	ENSETEG00000017163	TRMT5	87	81.360	Echinops_telfairi
ENSG00000126814	TRMT5	73	42.308	ENSEBUG00000002145	trmt5	64	42.308	Eptatretus_burgeri
ENSG00000126814	TRMT5	99	88.386	ENSEASG00005016123	TRMT5	100	88.386	Equus_asinus_asinus
ENSG00000126814	TRMT5	99	88.780	ENSECAG00000000057	TRMT5	100	88.780	Equus_caballus
ENSG00000126814	TRMT5	96	55.466	ENSELUG00000011314	trmt5	86	60.000	Esox_lucius
ENSG00000126814	TRMT5	99	85.347	ENSFCAG00000006820	TRMT5	97	85.347	Felis_catus
ENSG00000126814	TRMT5	98	61.446	ENSFALG00000003430	TRMT5	96	61.847	Ficedula_albicollis
ENSG00000126814	TRMT5	99	84.752	ENSFDAG00000018556	TRMT5	99	84.752	Fukomys_damarensis
ENSG00000126814	TRMT5	84	56.977	ENSFHEG00000008062	trmt5	89	57.143	Fundulus_heteroclitus
ENSG00000126814	TRMT5	84	54.042	ENSGMOG00000010858	trmt5	99	54.042	Gadus_morhua
ENSG00000126814	TRMT5	98	64.271	ENSGALG00000011904	TRMT5	99	64.200	Gallus_gallus
ENSG00000126814	TRMT5	84	54.651	ENSGAFG00000004103	trmt5	89	54.801	Gambusia_affinis
ENSG00000126814	TRMT5	85	56.351	ENSGACG00000008470	trmt5	94	63.370	Gasterosteus_aculeatus
ENSG00000126814	TRMT5	99	65.209	ENSGAGG00000023507	TRMT5	100	65.209	Gopherus_agassizii
ENSG00000126814	TRMT5	99	99.010	ENSGGOG00000006831	TRMT5	100	99.010	Gorilla_gorilla
ENSG00000126814	TRMT5	84	55.684	ENSHBUG00000023000	trmt5	90	55.711	Haplochromis_burtoni
ENSG00000126814	TRMT5	88	86.222	ENSHGLG00000013713	TRMT5	100	86.222	Heterocephalus_glaber_female
ENSG00000126814	TRMT5	99	80.671	ENSHGLG00100002392	TRMT5	99	80.671	Heterocephalus_glaber_male
ENSG00000126814	TRMT5	82	56.010	ENSHCOG00000012203	trmt5	99	56.174	Hippocampus_comes
ENSG00000126814	TRMT5	83	55.427	ENSIPUG00000002612	trmt5	88	55.427	Ictalurus_punctatus
ENSG00000126814	TRMT5	99	84.158	ENSSTOG00000011865	TRMT5	99	84.158	Ictidomys_tridecemlineatus
ENSG00000126814	TRMT5	85	82.488	ENSJJAG00000009935	Trmt5	100	82.488	Jaculus_jaculus
ENSG00000126814	TRMT5	84	55.581	ENSKMAG00000005992	trmt5	99	55.738	Kryptolebias_marmoratus
ENSG00000126814	TRMT5	84	56.744	ENSLBEG00000023240	trmt5	98	56.909	Labrus_bergylta
ENSG00000126814	TRMT5	86	65.837	ENSLACG00000018464	TRMT5	96	66.434	Latimeria_chalumnae
ENSG00000126814	TRMT5	86	61.678	ENSLOCG00000010120	trmt5	99	61.678	Lepisosteus_oculatus
ENSG00000126814	TRMT5	99	85.178	ENSLAFG00000003616	TRMT5	99	85.178	Loxodonta_africana
ENSG00000126814	TRMT5	100	94.106	ENSMFAG00000002940	TRMT5	100	94.106	Macaca_fascicularis
ENSG00000126814	TRMT5	99	87.327	ENSMMUG00000013611	TRMT5	99	87.327	Macaca_mulatta
ENSG00000126814	TRMT5	100	94.303	ENSMNEG00000000131	TRMT5	100	94.303	Macaca_nemestrina
ENSG00000126814	TRMT5	100	94.499	ENSMLEG00000043649	TRMT5	100	94.499	Mandrillus_leucophaeus
ENSG00000126814	TRMT5	84	56.047	ENSMAMG00000001758	trmt5	87	56.206	Mastacembelus_armatus
ENSG00000126814	TRMT5	84	55.093	ENSMZEG00005007457	trmt5	90	55.116	Maylandia_zebra
ENSG00000126814	TRMT5	98	63.872	ENSMGAG00000013565	TRMT5	99	63.872	Meleagris_gallopavo
ENSG00000126814	TRMT5	97	78.831	ENSMAUG00000016091	Trmt5	98	78.831	Mesocricetus_auratus
ENSG00000126814	TRMT5	99	87.574	ENSMICG00000044351	TRMT5	100	87.574	Microcebus_murinus
ENSG00000126814	TRMT5	99	78.218	ENSMOCG00000020904	Trmt5	99	78.218	Microtus_ochrogaster
ENSG00000126814	TRMT5	84	57.710	ENSMMOG00000012159	trmt5	87	57.845	Mola_mola
ENSG00000126814	TRMT5	96	73.494	ENSMODG00000008664	TRMT5	98	73.494	Monodelphis_domestica
ENSG00000126814	TRMT5	98	52.096	ENSMALG00000009533	trmt5	88	56.876	Monopterus_albus
ENSG00000126814	TRMT5	99	74.653	MGP_CAROLIEiJ_G0017843	Trmt5	99	74.653	Mus_caroli
ENSG00000126814	TRMT5	99	75.842	ENSMUSG00000034442	Trmt5	99	75.842	Mus_musculus
ENSG00000126814	TRMT5	99	76.436	MGP_PahariEiJ_G0029601	Trmt5	99	76.436	Mus_pahari
ENSG00000126814	TRMT5	99	75.842	MGP_SPRETEiJ_G0018690	Trmt5	99	75.842	Mus_spretus
ENSG00000126814	TRMT5	97	85.253	ENSMPUG00000006435	TRMT5	83	85.253	Mustela_putorius_furo
ENSG00000126814	TRMT5	99	86.024	ENSMLUG00000002357	TRMT5	100	86.024	Myotis_lucifugus
ENSG00000126814	TRMT5	97	81.818	ENSNGAG00000012691	Trmt5	99	81.616	Nannospalax_galili
ENSG00000126814	TRMT5	84	55.787	ENSNBRG00000009536	trmt5	98	55.814	Neolamprologus_brichardi
ENSG00000126814	TRMT5	99	96.832	ENSNLEG00000013805	TRMT5	100	96.260	Nomascus_leucogenys
ENSG00000126814	TRMT5	61	65.605	ENSMEUG00000004767	-	100	65.605	Notamacropus_eugenii
ENSG00000126814	TRMT5	99	66.534	ENSOPRG00000011719	TRMT5	99	66.534	Ochotona_princeps
ENSG00000126814	TRMT5	93	81.741	ENSODEG00000013922	TRMT5	98	81.741	Octodon_degus
ENSG00000126814	TRMT5	84	55.787	ENSONIG00000020115	trmt5	81	55.944	Oreochromis_niloticus
ENSG00000126814	TRMT5	98	77.711	ENSOCUG00000014281	TRMT5	99	77.711	Oryctolagus_cuniculus
ENSG00000126814	TRMT5	84	54.884	ENSORLG00000015734	trmt5	90	55.035	Oryzias_latipes
ENSG00000126814	TRMT5	91	52.137	ENSORLG00020009860	trmt5	91	54.524	Oryzias_latipes_hni
ENSG00000126814	TRMT5	84	54.884	ENSORLG00015008653	trmt5	99	54.756	Oryzias_latipes_hsok
ENSG00000126814	TRMT5	84	55.711	ENSOMEG00000006629	trmt5	90	55.869	Oryzias_melastigma
ENSG00000126814	TRMT5	99	87.302	ENSOGAG00000016088	TRMT5	99	87.302	Otolemur_garnettii
ENSG00000126814	TRMT5	99	84.950	ENSOARG00000021132	TRMT5	99	84.950	Ovis_aries
ENSG00000126814	TRMT5	99	99.406	ENSPPAG00000035176	TRMT5	100	99.406	Pan_paniscus
ENSG00000126814	TRMT5	100	85.294	ENSPPRG00000013336	TRMT5	99	85.294	Panthera_pardus
ENSG00000126814	TRMT5	98	81.000	ENSPTIG00000006744	TRMT5	100	81.000	Panthera_tigris_altaica
ENSG00000126814	TRMT5	99	99.406	ENSPTRG00000006415	TRMT5	100	99.406	Pan_troglodytes
ENSG00000126814	TRMT5	100	94.303	ENSPANG00000016605	TRMT5	100	94.303	Papio_anubis
ENSG00000126814	TRMT5	84	57.809	ENSPKIG00000018196	trmt5	98	55.856	Paramormyrops_kingsleyae
ENSG00000126814	TRMT5	98	65.932	ENSPSIG00000014128	TRMT5	98	65.932	Pelodiscus_sinensis
ENSG00000126814	TRMT5	91	53.263	ENSPMGG00000003882	trmt5	82	57.143	Periophthalmus_magnuspinnatus
ENSG00000126814	TRMT5	99	77.426	ENSPEMG00000022664	Trmt5	99	77.426	Peromyscus_maniculatus_bairdii
ENSG00000126814	TRMT5	99	71.735	ENSPCIG00000020458	TRMT5	100	71.456	Phascolarctos_cinereus
ENSG00000126814	TRMT5	84	55.814	ENSPFOG00000008680	trmt5	98	55.972	Poecilia_formosa
ENSG00000126814	TRMT5	80	57.985	ENSPLAG00000014197	trmt5	87	58.168	Poecilia_latipinna
ENSG00000126814	TRMT5	84	55.814	ENSPMEG00000014848	trmt5	89	55.972	Poecilia_mexicana
ENSG00000126814	TRMT5	83	56.604	ENSPREG00000015503	trmt5	99	56.604	Poecilia_reticulata
ENSG00000126814	TRMT5	100	96.857	ENSPPYG00000005877	TRMT5	100	96.857	Pongo_abelii
ENSG00000126814	TRMT5	50	89.535	ENSPCAG00000006616	-	54	89.535	Procavia_capensis
ENSG00000126814	TRMT5	100	89.194	ENSPCOG00000017447	TRMT5	100	89.194	Propithecus_coquereli
ENSG00000126814	TRMT5	77	88.732	ENSPVAG00000015311	TRMT5	77	88.732	Pteropus_vampyrus
ENSG00000126814	TRMT5	84	55.658	ENSPNYG00000022005	trmt5	98	55.814	Pundamilia_nyererei
ENSG00000126814	TRMT5	86	55.580	ENSPNAG00000022427	trmt5	88	56.782	Pygocentrus_nattereri
ENSG00000126814	TRMT5	97	76.876	ENSRNOG00000007785	Trmt5	98	81.222	Rattus_norvegicus
ENSG00000126814	TRMT5	100	95.088	ENSRBIG00000033903	TRMT5	100	95.088	Rhinopithecus_bieti
ENSG00000126814	TRMT5	100	95.285	ENSRROG00000035334	TRMT5	100	95.285	Rhinopithecus_roxellana
ENSG00000126814	TRMT5	79	36.326	YHR070W	-	95	36.326	Saccharomyces_cerevisiae
ENSG00000126814	TRMT5	100	92.927	ENSSBOG00000027786	TRMT5	100	92.927	Saimiri_boliviensis_boliviensis
ENSG00000126814	TRMT5	98	73.705	ENSSHAG00000003232	TRMT5	100	73.705	Sarcophilus_harrisii
ENSG00000126814	TRMT5	84	55.452	ENSSFOG00015013093	trmt5	97	55.607	Scleropages_formosus
ENSG00000126814	TRMT5	84	55.711	ENSSMAG00000001616	trmt5	89	55.738	Scophthalmus_maximus
ENSG00000126814	TRMT5	84	57.343	ENSSDUG00000019541	trmt5	86	57.512	Seriola_dumerili
ENSG00000126814	TRMT5	84	56.977	ENSSLDG00000001680	trmt5	98	57.143	Seriola_lalandi_dorsalis
ENSG00000126814	TRMT5	99	83.730	ENSSARG00000012431	TRMT5	99	83.730	Sorex_araneus
ENSG00000126814	TRMT5	96	62.372	ENSSPUG00000010098	TRMT5	97	62.372	Sphenodon_punctatus
ENSG00000126814	TRMT5	84	56.512	ENSSPAG00000012940	trmt5	90	56.674	Stegastes_partitus
ENSG00000126814	TRMT5	98	86.427	ENSSSCG00000024529	TRMT5	100	86.573	Sus_scrofa
ENSG00000126814	TRMT5	92	61.996	ENSTGUG00000012988	TRMT5	98	61.996	Taeniopygia_guttata
ENSG00000126814	TRMT5	87	55.430	ENSTRUG00000010888	trmt5	91	55.708	Takifugu_rubripes
ENSG00000126814	TRMT5	85	56.881	ENSTNIG00000017342	trmt5	98	57.044	Tetraodon_nigroviridis
ENSG00000126814	TRMT5	99	84.950	ENSTBEG00000005659	TRMT5	99	84.950	Tupaia_belangeri
ENSG00000126814	TRMT5	99	86.166	ENSTTRG00000013839	TRMT5	100	86.166	Tursiops_truncatus
ENSG00000126814	TRMT5	96	86.151	ENSUAMG00000023288	TRMT5	98	86.151	Ursus_americanus
ENSG00000126814	TRMT5	85	86.927	ENSUMAG00000013736	TRMT5	99	86.927	Ursus_maritimus
ENSG00000126814	TRMT5	100	85.098	ENSVPAG00000002392	TRMT5	100	85.098	Vicugna_pacos
ENSG00000126814	TRMT5	96	84.725	ENSVVUG00000029464	TRMT5	99	84.725	Vulpes_vulpes
ENSG00000126814	TRMT5	88	62.277	ENSXETG00000014455	trmt5	90	62.277	Xenopus_tropicalis
ENSG00000126814	TRMT5	84	55.814	ENSXCOG00000008547	trmt5	91	55.972	Xiphophorus_couchianus
ENSG00000126814	TRMT5	84	56.047	ENSXMAG00000013474	trmt5	93	56.206	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0002939	tRNA N1-guanine methylation	21873635.	IBA	Process
GO:0005634	nucleus	-	IEA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005759	mitochondrial matrix	21873635.	IBA	Component
GO:0005759	mitochondrial matrix	26189817.	IDA	Component
GO:0008175	tRNA methyltransferase activity	21873635.	IBA	Function
GO:0009019	tRNA (guanine-N1-)-methyltransferase activity	21873635.	IBA	Function
GO:0030488	tRNA methylation	21873635.	IBA	Process
GO:0052906	tRNA (guanine(37)-N(1))-methyltransferase activity	-	IEA	Function
GO:0070901	mitochondrial tRNA methylation	21873635.	IBA	Process
GO:0070901	mitochondrial tRNA methylation	26189817.	IMP	Process