EuRBPDB

Description

Ensembl ID: ENSG00000126883 (Gene tree)
Gene ID: 8021
Gene Symbol: NUP214
Alias: CAIN|CAN|D9S46E|N214
Full Name: nucleoporin 214
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 109,712 bases
Position: chr9:131,124,959-131,234,670
Accession: 8064
RBP type: non-canonical RBP
Summary: The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene is a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is localized to the cytoplasmic face of the nuclear pore complex where it is required for proper cell cycle progression and nucleocytoplasmic transport. The 3' portion of this gene forms a fusion gene with the DEK gene on chromosome 6 in a t(6,9) translocation associated with acute myeloid leukemia and myelodysplastic syndrome. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
16094715	Screening of genes of proteins interacting with p7 protein of hepatitis C virus from human liver cDNA library by yeast two-hybrid system.	World J Gastroenterol	2005 Aug 14	Huang YP	-
19219046	The mRNA export protein DBP5 binds RNA and the cytoplasmic nucleoporin NUP214 in a mutually exclusive manner.	Nat Struct Mol Biol	2009 Mar	von Moeller H	doi: 10.1038/nsmb.1561
20023400	Mechanistic insights into mRNA export through structures of Dbp5.	RNA Biol	2010 Jan-Feb	Ling SH	-
25410864	Nuclear import of adenovirus DNA involves direct interaction of hexon with an N-terminal domain of the nucleoporin Nup214.	J Virol	2015 Feb	Cassany A	doi: 10.1128/JVI.02639-14

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000489260	NUP214-209	649	-	-	- (aa)	-	-
ENST00000451030	NUP214-203	5021	-	ENSP00000405014	1519 (aa)	-	A0A0A0MSW3
ENST00000411637	NUP214-202	7538	-	ENSP00000396576	2080 (aa)	-	P35658
ENST00000528406	NUP214-219	393	-	ENSP00000433654	78 (aa)	-	H0YDI2
ENST00000453861	NUP214-204	3208	-	ENSP00000416934	967 (aa)	-	H0Y837
ENST00000483497	NUP214-208	3275	-	ENSP00000436793	916 (aa)	-	B7ZAV2
ENST00000498010	NUP214-211	483	-	ENSP00000435583	113 (aa)	-	H0YED3
ENST00000531929	NUP214-227	593	-	-	- (aa)	-	-
ENST00000524578	NUP214-212	524	-	-	- (aa)	-	-
ENST00000531584	NUP214-225	545	-	ENSP00000435874	52 (aa)	-	E9PS86
ENST00000525561	NUP214-214	487	-	-	- (aa)	-	-
ENST00000526346	NUP214-216	577	-	ENSP00000437139	140 (aa)	-	H0YF36
ENST00000359428	NUP214-201	7600	-	ENSP00000352400	2090 (aa)	-	P35658
ENST00000530630	NUP214-222	536	-	-	- (aa)	-	-
ENST00000529286	NUP214-220	493	-	-	- (aa)	-	-
ENST00000470765	NUP214-206	620	-	-	- (aa)	-	-
ENST00000525980	NUP214-215	2274	-	-	- (aa)	-	-
ENST00000465486	NUP214-205	1068	-	-	- (aa)	-	-
ENST00000476004	NUP214-207	502	-	ENSP00000433606	145 (aa)	-	H0YDH2
ENST00000530863	NUP214-224	560	-	ENSP00000434223	187 (aa)	-	H0YDS4
ENST00000530491	NUP214-221	502	-	-	- (aa)	-	-
ENST00000530843	NUP214-223	189	-	-	- (aa)	-	-
ENST00000525384	NUP214-213	840	-	-	- (aa)	-	-
ENST00000531600	NUP214-226	1775	-	ENSP00000435364	495 (aa)	-	E9PKD2
ENST00000496921	NUP214-210	2977	-	-	- (aa)	-	-
ENST00000528114	NUP214-218	575	-	-	- (aa)	-	-
ENST00000526412	NUP214-217	551	-	-	- (aa)	-	-

Gene Model

Pathways

Pathway ID	Pathway Name	Source
hsa03013	RNA transport	KEGG

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000278	mitotic cell cycle	-	IEA	Process
GO:0005049	nuclear export signal receptor activity	10358091.	IDA	Function
GO:0005515	protein binding	11545741.11777942.14766228.	IPI	Function
GO:0005634	nucleus	-	IDA	Component
GO:0005643	nuclear pore	21873635.	IBA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005925	focal adhesion	-	IDA	Component
GO:0006110	regulation of glycolytic process	-	TAS	Process
GO:0006406	mRNA export from nucleus	10557333.	IMP	Process
GO:0006406	mRNA export from nucleus	-	TAS	Process
GO:0006409	tRNA export from nucleus	-	TAS	Process
GO:0006606	protein import into nucleus	21873635.	IBA	Process
GO:0006611	protein export from nucleus	12191473.	IMP	Process
GO:0008139	nuclear localization sequence binding	21873635.	IBA	Function
GO:0016032	viral process	-	TAS	Process
GO:0016925	protein sumoylation	-	TAS	Process
GO:0017056	structural constituent of nuclear pore	21873635.	IBA	Function
GO:0019083	viral transcription	-	TAS	Process
GO:0043231	intracellular membrane-bounded organelle	-	IDA	Component
GO:0043488	regulation of mRNA stability	-	TAS	Process
GO:0043657	host cell	-	IEA	Component
GO:0046822	regulation of nucleocytoplasmic transport	11000203.	IMP	Process
GO:0051726	regulation of cell cycle	-	IEA	Process
GO:0060964	regulation of gene silencing by miRNA	-	TAS	Process
GO:0075733	intracellular transport of virus	-	TAS	Process
GO:1900034	regulation of cellular response to heat	-	TAS	Process
GO:1990876	cytoplasmic side of nuclear pore	8108440.	IDA	Component