EuRBPDB

Description

Ensembl ID: ENSG00000127481 (Gene tree)
Gene ID: 23352
Gene Symbol: UBR4
Alias: KIAA1307|KIAA0462|RBAF600|ZUBR1
Full Name: ubiquitin protein ligase E3 component n-recognin 4
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 135,814 bases
Position: chr1:19,074,506-19,210,319
Accession: 30313
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is an E3 ubiquitin-protein ligase that interacts with the retinoblastoma-associated protein in the nucleus and with calcium-bound calmodulin in the cytoplasm. The encoded protein appears to be a cytoskeletal component in the cytoplasm and part of the chromatin scaffold in the nucleus. In addition, this protein is a target of the human papillomavirus type 16 E7 oncoprotein. [provided by RefSeq, Aug 2010]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000497018	UBR4-217	183	-	-	- (aa)	-	-
ENST00000375224	UBR4-202	3475	-	ENSP00000364372	890 (aa)	-	X6R960
ENST00000375225	UBR4-203	1533	-	ENSP00000364373	258 (aa)	-	Q5TBN9
ENST00000494503	UBR4-216	598	-	-	- (aa)	-	-
ENST00000459947	UBR4-208	3873	-	-	- (aa)	-	-
ENST00000375218	UBR4-201	4031	-	ENSP00000364366	212 (aa)	-	Q5T4S7
ENST00000419533	UBR4-206	5583	-	-	- (aa)	-	-
ENST00000375254	UBR4-204	15906	XM_011541108	ENSP00000364403	5183 (aa)	XP_011539410	Q5T4S7
ENST00000492606	UBR4-215	314	-	-	- (aa)	-	-
ENST00000467272	UBR4-211	891	-	-	- (aa)	-	-
ENST00000486515	UBR4-214	536	-	-	- (aa)	-	-
ENST00000465036	UBR4-209	392	-	-	- (aa)	-	-
ENST00000483922	UBR4-213	543	-	-	- (aa)	-	-
ENST00000425413	UBR4-207	2954	-	ENSP00000395313	984 (aa)	-	X6RE05
ENST00000475973	UBR4-212	600	-	-	- (aa)	-	-
ENST00000466969	UBR4-210	510	-	-	- (aa)	-	-
ENST00000417040	UBR4-205	6175	-	ENSP00000404897	2058 (aa)	-	A0A0A0MSW0

Gene Model

Pathways

Pathway ID	Pathway Name	Source
hsa05165	Human papillomavirus infection	KEGG
hsa05203	Viral carcinogenesis	KEGG

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004842	ubiquitin-protein transferase activity	21873635.	IBA	Function
GO:0004842	ubiquitin-protein transferase activity	23932781.	IDA	Function
GO:0005515	protein binding	16061792.22810586.23932781.	IPI	Function
GO:0005516	calmodulin binding	-	IEA	Function
GO:0005654	nucleoplasm	21873635.	IBA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005813	centrosome	21873635.	IBA	Component
GO:0005813	centrosome	-	IDA	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005886	plasma membrane	-	TAS	Component
GO:0006511	ubiquitin-dependent protein catabolic process	21873635.	IBA	Process
GO:0006511	ubiquitin-dependent protein catabolic process	23932781.	IDA	Process
GO:0008270	zinc ion binding	-	IEA	Function
GO:0016020	membrane	19946888.	HDA	Component
GO:0016021	integral component of membrane	-	IEA	Component
GO:0016032	viral process	-	IEA	Process
GO:0016567	protein ubiquitination	-	IEA	Process
GO:0035579	specific granule membrane	-	TAS	Component
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0070821	tertiary granule membrane	-	TAS	Component
GO:0101003	ficolin-1-rich granule membrane	-	TAS	Component