EuRBPDB

Description

Ensembl ID: ENSG00000127483 (Gene tree)
Gene ID: 50809
Gene Symbol: HP1BP3
Alias: HP1-BP74
Full Name: heterochromatin protein 1 binding protein 3
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 44,663 bases
Position: chr1:20,742,661-20,787,323
Accession: 24973
RBP type: non-canonical RBP
Summary: (Heterochromatin Protein 1 Binding Protein 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleosome binding.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000438032	HP1BP3-210	1159	-	ENSP00000403039	327 (aa)	-	X6RGJ2
ENST00000437575	HP1BP3-209	473	-	ENSP00000402096	45 (aa)	-	B0QZK6
ENST00000487117	HP1BP3-212	1598	-	-	- (aa)	-	-
ENST00000488722	HP1BP3-213	639	-	-	- (aa)	-	-
ENST00000491748	HP1BP3-214	706	-	-	- (aa)	-	-
ENST00000414993	HP1BP3-204	727	-	ENSP00000405362	75 (aa)	-	B0QZK9
ENST00000424732	HP1BP3-208	970	-	ENSP00000402754	278 (aa)	-	Q5SWC8
ENST00000419490	HP1BP3-206	538	-	ENSP00000397656	40 (aa)	-	B0QZK5
ENST00000419948	HP1BP3-207	759	-	ENSP00000391721	253 (aa)	-	B0QZK4
ENST00000312239	HP1BP3-201	3938	XM_005245875	ENSP00000312625	553 (aa)	XP_005245932	Q5SSJ5
ENST00000443615	HP1BP3-211	557	-	ENSP00000401874	19 (aa)	-	B0QZK7
ENST00000375003	HP1BP3-203	4822	XM_024447376	ENSP00000364142	401 (aa)	XP_024303144	Q5SSJ5
ENST00000375000	HP1BP3-202	928	-	ENSP00000364139	133 (aa)	-	Q5SSJ5
ENST00000417710	HP1BP3-205	572	-	ENSP00000391281	124 (aa)	-	B0QZK8

Gene Model

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000127483	Platelet Function Tests	3.4428500E-005	-
ENSG00000127483	Cognition Disorders	1E-7	26252872
ENSG00000127483	Cognitive Dysfunction	1E-7	26252872

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000127483	rs55961051	1	20772323	G	Cognitive decline rate in late mild cognitive impairment	26252872	[0.36-0.78] unit increase	0.5693	HP_0100543\|EFO_0007710
ENSG00000127483	rs7548269	1	20762979	T	Physical activity (walking duration)	30531941	[0.017-0.037] SD units decrease	0.027	EFO_0008002
ENSG00000127483	rs12404954	1	20748234	A	Adventurousness	30643258	[0.01-0.018] unit decrease	0.014318888	EFO_0008579
ENSG00000127483	rs12404954	1	20748234	G	Morning person	30696823		1.0314595	EFO_0008328

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000127483	HP1BP3	100	94.737	ENSMUSG00000028759	Hp1bp3	100	91.765	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000786	nucleosome	-	IEA	Component
GO:0003677	DNA binding	20042602.	IDA	Function
GO:0005515	protein binding	20042602.25416956.	IPI	Function
GO:0005634	nucleus	24830416.	IDA	Component
GO:0005694	chromosome	20042602.24830416.	IDA	Component
GO:0006334	nucleosome assembly	-	IEA	Process
GO:0006355	regulation of transcription, DNA-templated	24830416.	IMP	Process
GO:0016607	nuclear speck	-	IDA	Component
GO:0031491	nucleosome binding	20042602.	IDA	Function
GO:0042127	regulation of cell proliferation	24830416.	IMP	Process
GO:0070828	heterochromatin organization	24830416.	IMP	Process
GO:0071456	cellular response to hypoxia	25100860.	IDA	Process
GO:0097298	regulation of nucleus size	24830416.	IMP	Process