EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000127616 (Gene tree)
Gene ID: 6597
Gene Symbol: SMARCA4
Alias: hSNF2b|BRG1|BAF190|SNF2|SWI2|SNF2-BETA|SNF2LB|FLJ39786|SNF2L4
Full Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 118,602 bases
Position: chr19:10,960,825-11,079,426
Accession: 11100
RBP type: canonical RBP
Summary: The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000495457	ResIII	PF04851.15	1.3e-09	1	1
ENSP00000495802	ResIII	PF04851.15	3.4e-09	1	1
ENSP00000496176	ResIII	PF04851.15	3.6e-09	1	1
ENSP00000494159	ResIII	PF04851.15	3.6e-09	1	1
ENSP00000496331	ResIII	PF04851.15	3.7e-09	1	1
ENSP00000494915	ResIII	PF04851.15	3.7e-09	1	1
ENSP00000495355	ResIII	PF04851.15	4e-09	1	1
ENSP00000496074	ResIII	PF04851.15	4.1e-09	1	1
ENSP00000496230	ResIII	PF04851.15	4.1e-09	1	1
ENSP00000493615	ResIII	PF04851.15	4.2e-09	1	1
ENSP00000495599	ResIII	PF04851.15	4.3e-09	1	1
ENSP00000496004	ResIII	PF04851.15	5.6e-09	1	1
ENSP00000392837	ResIII	PF04851.15	6.4e-09	1	1
ENSP00000494463	ResIII	PF04851.15	6.4e-09	1	1
ENSP00000466963	ResIII	PF04851.15	6.4e-09	1	1
ENSP00000494676	ResIII	PF04851.15	6.4e-09	1	1
ENSP00000494772	ResIII	PF04851.15	6.4e-09	1	1
ENSP00000495536	ResIII	PF04851.15	6.4e-09	1	1
ENSP00000464778	ResIII	PF04851.15	6.4e-09	1	1
ENSP00000445036	ResIII	PF04851.15	6.4e-09	1	1
ENSP00000495548	ResIII	PF04851.15	6.4e-09	1	1
ENSP00000496635	ResIII	PF04851.15	6.4e-09	1	1
ENSP00000494353	ResIII	PF04851.15	6.6e-09	1	1
ENSP00000496498	ResIII	PF04851.15	6.6e-09	1	1
ENSP00000343896	ResIII	PF04851.15	6.6e-09	1	1
ENSP00000395654	ResIII	PF04851.15	6.6e-09	1	1
ENSP00000493975	ResIII	PF04851.15	6.6e-09	1	1
ENSP00000397783	ResIII	PF04851.15	6.8e-09	1	1
ENSP00000495368	ResIII	PF04851.15	6.8e-09	1	1
ENSP00000414727	ResIII	PF04851.15	6.8e-09	1	1
ENSP00000495802	BRK	PF07533.16	2.9e-17	1	1
ENSP00000494159	BRK	PF07533.16	3e-17	1	1
ENSP00000496176	BRK	PF07533.16	3.1e-17	1	1
ENSP00000494915	BRK	PF07533.16	3.1e-17	1	1
ENSP00000496331	BRK	PF07533.16	3.1e-17	1	1
ENSP00000495355	BRK	PF07533.16	3.2e-17	1	1
ENSP00000496074	BRK	PF07533.16	3.3e-17	1	1
ENSP00000495599	BRK	PF07533.16	3.4e-17	1	1
ENSP00000493615	BRK	PF07533.16	3.4e-17	1	1
ENSP00000496230	BRK	PF07533.16	3.7e-17	1	1
ENSP00000496004	BRK	PF07533.16	4.3e-17	1	1
ENSP00000464778	BRK	PF07533.16	5e-17	1	1
ENSP00000445036	BRK	PF07533.16	5e-17	1	1
ENSP00000495548	BRK	PF07533.16	5e-17	1	1
ENSP00000496635	BRK	PF07533.16	5e-17	1	1
ENSP00000392837	BRK	PF07533.16	5.1e-17	1	1
ENSP00000494463	BRK	PF07533.16	5.1e-17	1	1
ENSP00000466963	BRK	PF07533.16	5.1e-17	1	1
ENSP00000494676	BRK	PF07533.16	5.1e-17	1	1
ENSP00000494772	BRK	PF07533.16	5.1e-17	1	1
ENSP00000495536	BRK	PF07533.16	5.1e-17	1	1
ENSP00000494353	BRK	PF07533.16	5.1e-17	1	1
ENSP00000496498	BRK	PF07533.16	5.1e-17	1	1
ENSP00000493975	BRK	PF07533.16	5.1e-17	1	1
ENSP00000343896	BRK	PF07533.16	5.2e-17	1	1
ENSP00000395654	BRK	PF07533.16	5.2e-17	1	1
ENSP00000397783	BRK	PF07533.16	5.2e-17	1	1
ENSP00000495368	BRK	PF07533.16	5.2e-17	1	1
ENSP00000414727	BRK	PF07533.16	5.3e-17	1	1
ENSP00000495457	BRK	PF07533.16	9.2e-08	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
24993775	Long non-coding RNA urothelial carcinoma associated1 induces cell replication by inhibiting BRG1 in 5637 cells.	Oncol Rep	2014 Sep	Wang X	doi: 10.3892/or.2014.3309
26138476	Evf2 lncRNA/BRG1/DLX1 interactions reveal RNA-dependent inhibition of chromatin remodeling.	Development	2015 Aug 1	Cajigas I	doi: 10.1242/dev.126318
26577303	Postovulatory aging affects dynamics of mRNA, expression and localization of maternal effect proteins, spindle integrity and pericentromeric proteins in mouse oocytes.	Hum Reprod	2016 Jan	Trapphoff T	doi: 10.1093/humrep/dev279
30664740	Xist RNA antagonizes the SWI/SNF chromatin remodeler BRG1 on the inactive X chromosome.	Nat Struct Mol Biol	2019 Feb	Jegu T	doi: 10.1038/s41594-018-0176-8
17686768	Design of a specific activator for skeletal muscle sodium channels uncovers channel architecture.	J Biol Chem	2007 Oct 5	Cohen L	-
10857751	Cloning and characterization of HARP/SMARCAL1: a prokaryotic HepA-related SNF2 helicase protein from human and mouse.	Genomics	2000 May 1	Coleman MA	-
15331701	VP16-dependent association of chromatin-modifying coactivators and underrepresentation of histones at immediate-early gene promoters during herpes simplex virus infection.	J Virol	2004 Sep	Herrera FJ	-
18070923	Different requirements of the SWI/SNF complex for robust nucleosome displacement at promoters of heat shock factor and Msn2- and Msn4-regulated heat shock genes.	Mol Cell Biol	2008 Feb	Erkina TY	-
17726060	P-STAT1 mediates higher-order chromatin remodelling of the human MHC in response to IFNgamma.	J Cell Sci	2007 Sep 15	Christova R	-
17011493	The RNA helicases p68/p72 and the noncoding RNA SRA are coregulators of MyoD and skeletal muscle differentiation.	Dev Cell	2006 Oct	Caretti G	-
20506188	The human SWI/SNF complex associates with RUNX1 to control transcription of hematopoietic target genes.	J Cell Physiol	2010 Nov	Bakshi R	doi: 10.1002/jcp.22240.
27797380	DNA demethylation induces SALL4 gene re-expression in subgroups of hepatocellular carcinoma associated with Hepatitis B or C virus infection.	Oncogene	2017 Apr 27	Fan H	doi: 10.1038/onc.2016.399
28236308	PRMT5 restricts hepatitis B virus replication through epigenetic repression of covalently closed circular DNA transcription and interference with pregenomic RNA encapsidation.	Hepatology	2017 Aug	Zhang W	doi: 10.1002/hep.29133
25972460	IUGR increases chromatin-remodeling factor Brg1 expression and binding to GR exon 1.7 promoter in newborn male rat hippocampus.	Am J Physiol Regul Integr Comp Physiol	2015 Jul 15	Ke X	doi: 10.1152/ajpregu.00495.2014
31111478	Long noncoding RNA CPS1-IT1 suppresses melanoma cell metastasis through inhibiting Cyr61 via competitively binding to BRG1.	J Cell Physiol	2019 May 20	Zhou X	doi: 10.1002/jcp.28764

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000644267	SMARCA4-232	3382	-	-	- (aa)	-	-
ENST00000586122	SMARCA4-209	512	-	-	- (aa)	-	-
ENST00000645648	SMARCA4-242	3250	-	ENSP00000493521	385 (aa)	-	A0A2R8YCY3
ENST00000646484	SMARCA4-245	5579	-	ENSP00000495536	1614 (aa)	-	P51532
ENST00000585799	SMARCA4-208	3842	-	-	- (aa)	-	-
ENST00000644760	SMARCA4-236	740	-	ENSP00000496682	157 (aa)	-	A0A2R8Y866
ENST00000647268	SMARCA4-254	3522	-	ENSP00000496176	1065 (aa)	-	A0A2R8YF58
ENST00000444061	SMARCA4-204	5393	-	ENSP00000392837	1613 (aa)	-	P51532
ENST00000429416	SMARCA4-203	5665	-	ENSP00000395654	1647 (aa)	-	P51532
ENST00000344626	SMARCA4-201	5791	XM_024451660	ENSP00000343896	1647 (aa)	XP_024307428	P51532
ENST00000591595	SMARCA4-217	3377	-	-	- (aa)	-	-
ENST00000647230	SMARCA4-253	5554	XM_024451666	ENSP00000494676	1614 (aa)	XP_024307434	P51532
ENST00000646889	SMARCA4-251	1659	-	-	- (aa)	-	-
ENST00000541122	SMARCA4-207	5139	-	ENSP00000445036	1617 (aa)	-	P51532
ENST00000642628	SMARCA4-222	5637	XM_024451661	ENSP00000496498	1646 (aa)	XP_024307429	A0A2R8Y7S2
ENST00000647011	SMARCA4-252	487	-	-	- (aa)	-	-
ENST00000642508	SMARCA4-221	2612	-	ENSP00000494154	799 (aa)	-	A0A2R8Y523
ENST00000642350	SMARCA4-220	3750	-	ENSP00000495355	1145 (aa)	-	A0A2R8Y6N0
ENST00000643995	SMARCA4-230	4817	-	ENSP00000496004	1455 (aa)	-	A0A2R8YGG3
ENST00000643534	SMARCA4-226	3426	-	ENSP00000495802	1041 (aa)	-	A0A2R8Y6V2
ENST00000646510	SMARCA4-246	5595	-	ENSP00000494772	1614 (aa)	-	P51532
ENST00000646513	SMARCA4-247	1127	-	ENSP00000495457	375 (aa)	-	A0A2R8YFV8
ENST00000645460	SMARCA4-241	5457	XM_024451667	ENSP00000494463	1613 (aa)	XP_024307435	P51532
ENST00000591545	SMARCA4-216	5192	-	ENSP00000496230	1165 (aa)	-	A0A2R8YGP5
ENST00000450717	SMARCA4-205	5506	XM_006722846	ENSP00000397783	1679 (aa)	XP_006722909	Q9HBD4
ENST00000644065	SMARCA4-231	3802	-	ENSP00000493615	1192 (aa)	-	A0A2R8Y440
ENST00000587988	SMARCA4-213	552	-	-	- (aa)	-	-
ENST00000643857	SMARCA4-228	3637	-	ENSP00000494159	1068 (aa)	-	A0A2R8Y526
ENST00000646746	SMARCA4-250	3680	-	ENSP00000496331	1081 (aa)	-	A0A2R8Y7Y7
ENST00000643208	SMARCA4-224	3940	-	ENSP00000496074	1165 (aa)	-	A0A2R8Y7F3
ENST00000646593	SMARCA4-248	3206	-	ENSP00000494341	55 (aa)	-	A0A2R8Y583
ENST00000644290	SMARCA4-233	3355	-	ENSP00000496190	192 (aa)	-	A0A2R8Y7R0
ENST00000643296	SMARCA4-225	5563	XM_024451664	ENSP00000496635	1617 (aa)	XP_024307432	P51532
ENST00000592158	SMARCA4-218	911	-	ENSP00000467200	221 (aa)	-	K7EP28
ENST00000646236	SMARCA4-244	2802	-	ENSP00000493925	234 (aa)	-	A0A2R8Y4R6
ENST00000644737	SMARCA4-235	5777	-	ENSP00000495548	1617 (aa)	-	P51532
ENST00000592604	SMARCA4-219	3358	-	-	- (aa)	-	-
ENST00000644963	SMARCA4-237	4045	-	ENSP00000495599	1198 (aa)	-	A0A2R8YG32
ENST00000643929	SMARCA4-229	1865	-	-	- (aa)	-	-
ENST00000645061	SMARCA4-238	4035	-	ENSP00000493690	985 (aa)	-	A0A2R8YDA1
ENST00000538456	SMARCA4-206	1108	-	ENSP00000495197	336 (aa)	-	A0A2R8YFK5
ENST00000586892	SMARCA4-210	559	-	-	- (aa)	-	-
ENST00000646693	SMARCA4-249	5774	XM_006722845	ENSP00000495368	1679 (aa)	XP_006722908	Q9HBD4
ENST00000586985	SMARCA4-212	1968	-	ENSP00000467796	348 (aa)	-	K7EQF0
ENST00000589677	SMARCA4-214	5181	XM_024451665	ENSP00000464778	1616 (aa)	XP_024307433	P51532
ENST00000642726	SMARCA4-223	5675	-	ENSP00000494353	1646 (aa)	-	A0A2R8Y7S2
ENST00000413806	SMARCA4-202	5512	-	ENSP00000414727	1681 (aa)	-	A0A0A0MT49
ENST00000590574	SMARCA4-215	5739	-	ENSP00000466963	1614 (aa)	-	P51532
ENST00000643549	SMARCA4-227	5609	-	ENSP00000493975	1649 (aa)	-	A0A2R8Y4P4
ENST00000645387	SMARCA4-240	627	-	ENSP00000496135	58 (aa)	-	A0A2R8YF38
ENST00000645236	SMARCA4-239	1887	-	ENSP00000494603	522 (aa)	-	A0A2R8Y5K3
ENST00000586921	SMARCA4-211	569	-	-	- (aa)	-	-
ENST00000646183	SMARCA4-243	3496	-	ENSP00000494915	1094 (aa)	-	A0A2R8YF80
ENST00000644327	SMARCA4-234	4237	-	ENSP00000493905	1047 (aa)	-	A0A2R8Y4C5

Gene Model

Click here to download ENSG00000127616's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04714	Thermogenesis	KEGG
hsa05225	Hepatocellular carcinoma	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000127616	Myocardial Infarction	3.5375197E-004	-
ENSG00000127616	Cholesterol, LDL	1.514e-007	19060910
ENSG00000127616	Cholesterol, LDL	7.542e-005	19060910
ENSG00000127616	Waist-Hip Ratio	9.1260000E-005	-
ENSG00000127616	Cholesterol, LDL	7.3910000E-005	-
ENSG00000127616	Eosinophils	2.4010000E-005	-
ENSG00000127616	Eosinophils	5.0020000E-005	-
ENSG00000127616	Cholesterol, LDL	2E-7	19060910
ENSG00000127616	Coronary Disease	3E-12	24262325
ENSG00000127616	Stroke	3E-12	24262325
ENSG00000127616	Coronary Disease	2E-11	24262325
ENSG00000127616	Stroke	2E-11	24262325
ENSG00000127616	Lipids	8E-17	22286219
ENSG00000127616	Coronary Disease	1E-9	21378990
ENSG00000127616	Coronary Disease	3E-11	24262325
ENSG00000127616	Cholesterol, LDL	1E-8	21347282
ENSG00000127616	Cholesterol	2E-113	25961943
ENSG00000127616	Dermatitis, Atopic	3E-6	25574825
ENSG00000127616	Lipoproteins	7E-47	27005778
ENSG00000127616	Metabolism	7E-47	27005778
ENSG00000127616	Coronary Artery Disease	4E-15	26343387
ENSG00000127616	Myocardial Infarction	3E-8	26343387
ENSG00000127616	Myocardial Infarction	2E-9	19198609
ENSG00000127616	Cholesterol, LDL	7E-142	25961943

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000127616	rs1122608	19	11052925	?	Coronary artery disease	24262325	[1.09-1.18]	1.1364	EFO_0001645
ENSG00000127616	rs1122608	19	11052925	?	Coronary artery disease or ischemic stroke	24262325			EFO_0000712\|EFO_0001645
ENSG00000127616	rs1122608	19	11052925	?	Coronary artery disease or large artery stroke	24262325			EFO_0005524\|EFO_0001645
ENSG00000127616	rs11669133	19	10981463	A	LDL cholesterol	21347282	[0.11-0.22] unit decrease	0.1671	EFO_0004611
ENSG00000127616	rs8099996	19	11063949	?	Inflammatory skin disease	25574825			EFO_0000274
ENSG00000127616	rs56289821	19	11077571	G	Coronary artery disease	26343387	[1.11- 1.18]	1.14	EFO_0000378
ENSG00000127616	rs55791371	19	11077477	A	Myocardial infarction	26343387	[1.07-1.15]	1.11	EFO_0000612
ENSG00000127616	rs112374545	19	11078223	C	LDL cholesterol	25961943	[0.23-0.27] s.d. increase	0.25	EFO_0004611
ENSG00000127616	rs1122608	19	11052925	G	Myocardial infarction (early onset)	19198609	[1.10-1.20]	1.15	EFO_0000612
ENSG00000127616	rs55791371	19	11077477	A	Coronary artery disease	29212778	[0.098-0.134] unit increase	0.1157	EFO_0000378
ENSG00000127616	rs8103309	19	11064259	?	Stroke	29531354			EFO_0000712
ENSG00000127616	rs8103309	19	11064259	?	Ischemic stroke	29531354			HP_0002140
ENSG00000127616	rs55791371	19	11077477	?	Lipid metabolism phenotypes	22286219	[0.2-0.32] unit decrease	0.26	EFO_0004529
ENSG00000127616	rs1122608	19	11052925	G	Coronary heart disease	21378990	[1.09-1.18]	1.14	EFO_0001645
ENSG00000127616	rs17001095	19	11022596	A	Total cholesterol levels	29507422	unit increase	0.042	EFO_0004574
ENSG00000127616	rs17001095	19	11022596	A	Total cholesterol levels	29507422	unit increase	0.042	EFO_0004574
ENSG00000127616	rs12052201	19	11048420	G	Total cholesterol levels	29507422	unit increase	0.069	EFO_0004574
ENSG00000127616	rs12052201	19	11048420	G	Total cholesterol levels	29507422	unit increase	0.065	EFO_0004574
ENSG00000127616	rs3786722	19	11050861	C	Total cholesterol levels	29507422	unit increase	0.068	EFO_0004574
ENSG00000127616	rs3786722	19	11050861	C	Total cholesterol levels	29507422	unit increase	0.064	EFO_0004574
ENSG00000127616	rs112374545	19	11078223	C	Total cholesterol levels	29507422	unit increase	0.189	EFO_0004574
ENSG00000127616	rs112374545	19	11078223	C	Total cholesterol levels	29507422	unit increase	0.15	EFO_0004574
ENSG00000127616	rs112374545	19	11078223	C	Total cholesterol levels	29507422	unit increase	0.194	EFO_0004574
ENSG00000127616	rs112374545	19	11078223	C	Total cholesterol levels	29507422	unit increase	0.185	EFO_0004574
ENSG00000127616	rs73015011	19	11079088	T	Total cholesterol levels	29507422	unit increase	0.191	EFO_0004574
ENSG00000127616	rs73015011	19	11079088	T	Total cholesterol levels	29507422	unit increase	0.152	EFO_0004574
ENSG00000127616	rs73015011	19	11079088	T	Total cholesterol levels	29507422	unit increase	0.308	EFO_0004574
ENSG00000127616	rs73015011	19	11079088	T	Total cholesterol levels	29507422	unit increase	0.215	EFO_0004574
ENSG00000127616	rs73015011	19	11079088	T	Total cholesterol levels	29507422	unit increase	0.19	EFO_0004574
ENSG00000127616	rs8103309	19	11064259	?	Ischemic stroke	29531354			HP_0002140
ENSG00000127616	rs17001095	19	11022596	A	Low density lipoprotein cholesterol levels	29507422	unit increase	0.046	EFO_0004611
ENSG00000127616	rs17001095	19	11022596	A	Low density lipoprotein cholesterol levels	29507422	unit increase	0.046	EFO_0004611
ENSG00000127616	rs12052201	19	11048420	G	Low density lipoprotein cholesterol levels	29507422	unit increase	0.077	EFO_0004611
ENSG00000127616	rs12052201	19	11048420	G	Low density lipoprotein cholesterol levels	29507422	unit increase	0.075	EFO_0004611
ENSG00000127616	rs3786722	19	11050861	C	Low density lipoprotein cholesterol levels	29507422	unit increase	0.076	EFO_0004611
ENSG00000127616	rs3786722	19	11050861	C	Low density lipoprotein cholesterol levels	29507422	unit increase	0.074	EFO_0004611
ENSG00000127616	rs112374545	19	11078223	C	Low density lipoprotein cholesterol levels	29507422	unit increase	0.22	EFO_0004611
ENSG00000127616	rs112374545	19	11078223	C	Low density lipoprotein cholesterol levels	29507422	unit increase	0.188	EFO_0004611
ENSG00000127616	rs112374545	19	11078223	C	Low density lipoprotein cholesterol levels	29507422	unit increase	0.223	EFO_0004611
ENSG00000127616	rs112374545	19	11078223	C	Low density lipoprotein cholesterol levels	29507422	unit increase	0.216	EFO_0004611
ENSG00000127616	rs73015011	19	11079088	T	Low density lipoprotein cholesterol levels	29507422	unit increase	0.222	EFO_0004611
ENSG00000127616	rs73015011	19	11079088	T	Low density lipoprotein cholesterol levels	29507422	unit increase	0.193	EFO_0004611
ENSG00000127616	rs73015011	19	11079088	T	Low density lipoprotein cholesterol levels	29507422	unit increase	0.31	EFO_0004611
ENSG00000127616	rs73015011	19	11079088	T	Low density lipoprotein cholesterol levels	29507422	unit increase	0.252	EFO_0004611
ENSG00000127616	rs73015011	19	11079088	T	Low density lipoprotein cholesterol levels	29507422	unit increase	0.222	EFO_0004611
ENSG00000127616	rs200495339	19	11078623	?	Carotid plaque	30510157	[0.067-0.137] unit decrease	0.1023	EFO_0009783
ENSG00000127616	rs8103309	19	11064259	?	Stroke	29531354			EFO_0000712

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000127616's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000127616	SMARCA4	91	35.589	ENSG00000119969	HELLS	69	47.500
ENSG00000127616	SMARCA4	90	42.105	ENSG00000173575	CHD2	88	64.646
ENSG00000127616	SMARCA4	99	90.202	ENSG00000080503	SMARCA2	99	98.000
ENSG00000127616	SMARCA4	64	50.000	ENSG00000166441	RPL27A	98	50.000
ENSG00000127616	SMARCA4	94	42.986	ENSG00000153147	SMARCA5	52	42.637
ENSG00000127616	SMARCA4	91	39.437	ENSG00000111642	CHD4	52	36.256

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000127616	SMARCA4	99	95.652	ENSAPOG00000004542	SMARCA4	98	83.313	Acanthochromis_polyacanthus
ENSG00000127616	SMARCA4	99	95.652	ENSAPOG00000003509	smarca4a	98	86.560	Acanthochromis_polyacanthus
ENSG00000127616	SMARCA4	100	98.726	ENSAMEG00000010868	SMARCA4	100	96.250	Ailuropoda_melanoleuca
ENSG00000127616	SMARCA4	99	100.000	ENSACIG00000021550	smarca4a	98	87.284	Amphilophus_citrinellus
ENSG00000127616	SMARCA4	99	95.652	ENSACIG00000003035	-	96	82.420	Amphilophus_citrinellus
ENSG00000127616	SMARCA4	99	95.652	ENSAOCG00000009450	-	97	87.558	Amphiprion_ocellaris
ENSG00000127616	SMARCA4	99	95.652	ENSAOCG00000019167	smarca4a	100	85.912	Amphiprion_ocellaris
ENSG00000127616	SMARCA4	99	95.652	ENSAPEG00000023108	-	99	83.018	Amphiprion_percula
ENSG00000127616	SMARCA4	99	95.652	ENSAPEG00000015559	smarca4a	100	85.981	Amphiprion_percula
ENSG00000127616	SMARCA4	99	95.652	ENSATEG00000001094	-	95	89.748	Anabas_testudineus
ENSG00000127616	SMARCA4	99	100.000	ENSATEG00000011524	smarca4a	100	87.447	Anabas_testudineus
ENSG00000127616	SMARCA4	100	99.762	ENSANAG00000036991	SMARCA4	100	99.762	Aotus_nancymaae
ENSG00000127616	SMARCA4	99	95.652	ENSACLG00000008638	-	98	83.094	Astatotilapia_calliptera
ENSG00000127616	SMARCA4	99	95.652	ENSACLG00000000163	smarca4a	98	88.235	Astatotilapia_calliptera
ENSG00000127616	SMARCA4	100	91.460	ENSAMXG00000011238	-	98	87.109	Astyanax_mexicanus
ENSG00000127616	SMARCA4	98	89.103	ENSAMXG00000021023	smarca4a	98	87.500	Astyanax_mexicanus
ENSG00000127616	SMARCA4	100	99.719	ENSBTAG00000019220	SMARCA4	100	99.009	Bos_taurus
ENSG00000127616	SMARCA4	100	99.762	ENSCJAG00000005936	SMARCA4	100	99.762	Callithrix_jacchus
ENSG00000127616	SMARCA4	100	99.752	ENSCAFG00000017584	SMARCA4	100	99.752	Canis_familiaris
ENSG00000127616	SMARCA4	100	99.752	ENSCAFG00020024620	SMARCA4	99	99.752	Canis_lupus_dingo
ENSG00000127616	SMARCA4	99	99.711	ENSCHIG00000015318	SMARCA4	100	94.558	Capra_hircus
ENSG00000127616	SMARCA4	100	99.531	ENSTSYG00000012966	SMARCA4	100	99.320	Carlito_syrichta
ENSG00000127616	SMARCA4	100	98.089	ENSCAPG00000015932	SMARCA4	95	98.024	Cavia_aperea
ENSG00000127616	SMARCA4	100	99.062	ENSCPOG00000015549	SMARCA4	100	99.009	Cavia_porcellus
ENSG00000127616	SMARCA4	100	100.000	ENSCCAG00000031660	SMARCA4	97	98.903	Cebus_capucinus
ENSG00000127616	SMARCA4	100	100.000	ENSCATG00000029530	SMARCA4	100	100.000	Cercocebus_atys
ENSG00000127616	SMARCA4	100	99.343	ENSCLAG00000011946	SMARCA4	100	98.698	Chinchilla_lanigera
ENSG00000127616	SMARCA4	100	98.129	ENSCPBG00000009994	SMARCA4	100	97.215	Chrysemys_picta_bellii
ENSG00000127616	SMARCA4	100	100.000	ENSCANG00000036013	SMARCA4	100	99.881	Colobus_angolensis_palliatus
ENSG00000127616	SMARCA4	100	99.625	ENSCGRG00001016732	Smarca4	100	99.195	Cricetulus_griseus_chok1gshd
ENSG00000127616	SMARCA4	100	99.625	ENSCGRG00000017242	Smarca4	100	99.195	Cricetulus_griseus_crigri
ENSG00000127616	SMARCA4	99	95.652	ENSCSEG00000014771	smarca4a	100	87.256	Cynoglossus_semilaevis
ENSG00000127616	SMARCA4	93	76.147	ENSCSEG00000009723	-	92	96.970	Cynoglossus_semilaevis
ENSG00000127616	SMARCA4	99	95.652	ENSCVAG00000003018	-	98	84.596	Cyprinodon_variegatus
ENSG00000127616	SMARCA4	99	100.000	ENSCVAG00000006979	smarca4a	99	86.889	Cyprinodon_variegatus
ENSG00000127616	SMARCA4	99	94.524	ENSDARG00000077226	smarca4a	100	87.401	Danio_rerio
ENSG00000127616	SMARCA4	100	91.736	ENSDARG00000104339	SMARCA4	95	84.651	Danio_rerio
ENSG00000127616	SMARCA4	97	100.000	ENSDNOG00000048847	SMARCA4	93	99.048	Dasypus_novemcinctus
ENSG00000127616	SMARCA4	94	99.543	ENSDORG00000002544	Smarca4	91	92.704	Dipodomys_ordii
ENSG00000127616	SMARCA4	100	98.726	ENSETEG00000013361	SMARCA4	94	89.263	Echinops_telfairi
ENSG00000127616	SMARCA4	100	99.442	ENSEASG00005006167	SMARCA4	98	99.442	Equus_asinus_asinus
ENSG00000127616	SMARCA4	100	99.531	ENSECAG00000008334	SMARCA4	100	99.504	Equus_caballus
ENSG00000127616	SMARCA4	97	95.000	ENSELUG00000010247	smarca4a	100	84.643	Esox_lucius
ENSG00000127616	SMARCA4	99	93.948	ENSELUG00000023232	-	93	85.791	Esox_lucius
ENSG00000127616	SMARCA4	100	99.757	ENSFCAG00000004894	SMARCA4	100	99.757	Felis_catus
ENSG00000127616	SMARCA4	97	100.000	ENSFALG00000004208	SMARCA4	93	91.917	Ficedula_albicollis
ENSG00000127616	SMARCA4	100	98.089	ENSFDAG00000012237	SMARCA4	97	98.851	Fukomys_damarensis
ENSG00000127616	SMARCA4	99	95.652	ENSFHEG00000007902	-	98	84.972	Fundulus_heteroclitus
ENSG00000127616	SMARCA4	99	95.101	ENSFHEG00000010182	smarca4a	100	87.044	Fundulus_heteroclitus
ENSG00000127616	SMARCA4	99	92.219	ENSGMOG00000005756	-	87	80.153	Gadus_morhua
ENSG00000127616	SMARCA4	94	81.944	ENSGMOG00000002649	smarca4a	87	81.882	Gadus_morhua
ENSG00000127616	SMARCA4	97	100.000	ENSGALG00000047145	SMARCA4	100	96.954	Gallus_gallus
ENSG00000127616	SMARCA4	94	97.260	ENSGAFG00000008827	-	98	82.217	Gambusia_affinis
ENSG00000127616	SMARCA4	99	100.000	ENSGAFG00000014900	smarca4a	99	88.655	Gambusia_affinis
ENSG00000127616	SMARCA4	99	95.652	ENSGACG00000016033	-	99	79.234	Gasterosteus_aculeatus
ENSG00000127616	SMARCA4	99	92.795	ENSGACG00000006691	smarca4a	100	85.584	Gasterosteus_aculeatus
ENSG00000127616	SMARCA4	100	98.311	ENSGAGG00000016757	SMARCA4	100	97.334	Gopherus_agassizii
ENSG00000127616	SMARCA4	100	100.000	ENSGGOG00000009882	SMARCA4	100	100.000	Gorilla_gorilla
ENSG00000127616	SMARCA4	99	95.652	ENSHBUG00000021172	smarca4a	100	87.637	Haplochromis_burtoni
ENSG00000127616	SMARCA4	99	95.652	ENSHBUG00000005447	-	99	83.144	Haplochromis_burtoni
ENSG00000127616	SMARCA4	100	99.485	ENSHGLG00000010519	SMARCA4	100	99.150	Heterocephalus_glaber_female
ENSG00000127616	SMARCA4	100	97.774	ENSHGLG00100013774	SMARCA4	100	97.713	Heterocephalus_glaber_male
ENSG00000127616	SMARCA4	99	95.652	ENSHCOG00000009510	smarca4a	96	86.876	Hippocampus_comes
ENSG00000127616	SMARCA4	100	94.524	ENSIPUG00000016346	-	98	83.960	Ictalurus_punctatus
ENSG00000127616	SMARCA4	100	92.011	ENSIPUG00000006107	smarca4a	100	87.942	Ictalurus_punctatus
ENSG00000127616	SMARCA4	100	99.719	ENSSTOG00000007939	SMARCA4	100	99.690	Ictidomys_tridecemlineatus
ENSG00000127616	SMARCA4	100	99.657	ENSJJAG00000012877	Smarca4	100	99.393	Jaculus_jaculus
ENSG00000127616	SMARCA4	99	95.652	ENSKMAG00000019518	-	98	87.346	Kryptolebias_marmoratus
ENSG00000127616	SMARCA4	99	95.652	ENSKMAG00000011931	smarca4a	100	86.544	Kryptolebias_marmoratus
ENSG00000127616	SMARCA4	99	92.219	ENSLBEG00000017383	smarca4a	84	82.565	Labrus_bergylta
ENSG00000127616	SMARCA4	94	89.495	ENSLBEG00000020655	-	81	83.151	Labrus_bergylta
ENSG00000127616	SMARCA4	93	82.873	ENSLACG00000015309	SMARCA4	100	88.425	Latimeria_chalumnae
ENSG00000127616	SMARCA4	99	100.000	ENSLOCG00000007820	smarca4a	79	92.587	Lepisosteus_oculatus
ENSG00000127616	SMARCA4	100	99.814	ENSLAFG00000001433	SMARCA4	100	99.814	Loxodonta_africana
ENSG00000127616	SMARCA4	100	100.000	ENSMFAG00000032146	SMARCA4	100	100.000	Macaca_fascicularis
ENSG00000127616	SMARCA4	100	100.000	ENSMMUG00000012042	SMARCA4	100	100.000	Macaca_mulatta
ENSG00000127616	SMARCA4	100	99.906	ENSMNEG00000028512	SMARCA4	100	99.752	Macaca_nemestrina
ENSG00000127616	SMARCA4	100	100.000	ENSMLEG00000034976	SMARCA4	100	99.940	Mandrillus_leucophaeus
ENSG00000127616	SMARCA4	99	100.000	ENSMAMG00000009256	smarca4a	100	87.333	Mastacembelus_armatus
ENSG00000127616	SMARCA4	99	95.652	ENSMAMG00000002841	-	98	86.931	Mastacembelus_armatus
ENSG00000127616	SMARCA4	99	95.652	ENSMZEG00005003889	smarca4a	100	87.401	Maylandia_zebra
ENSG00000127616	SMARCA4	99	95.652	ENSMZEG00005023861	-	98	83.794	Maylandia_zebra
ENSG00000127616	SMARCA4	100	99.252	ENSMAUG00000020731	Smarca4	100	99.072	Mesocricetus_auratus
ENSG00000127616	SMARCA4	100	99.753	ENSMICG00000009806	SMARCA4	100	99.753	Microcebus_murinus
ENSG00000127616	SMARCA4	100	99.158	ENSMOCG00000022209	Smarca4	100	99.134	Microtus_ochrogaster
ENSG00000127616	SMARCA4	95	100.000	ENSMMOG00000007571	smarca4a	98	85.522	Mola_mola
ENSG00000127616	SMARCA4	94	96.804	ENSMMOG00000008466	-	98	85.277	Mola_mola
ENSG00000127616	SMARCA4	100	99.056	ENSMODG00000006287	SMARCA4	100	98.604	Monodelphis_domestica
ENSG00000127616	SMARCA4	99	100.000	ENSMALG00000003388	smarca4a	100	87.248	Monopterus_albus
ENSG00000127616	SMARCA4	100	93.372	ENSMALG00000021534	-	99	80.820	Monopterus_albus
ENSG00000127616	SMARCA4	100	99.625	MGP_CAROLIEiJ_G0031879	Smarca4	100	99.526	Mus_caroli
ENSG00000127616	SMARCA4	100	99.625	ENSMUSG00000032187	Smarca4	100	99.258	Mus_musculus
ENSG00000127616	SMARCA4	100	99.625	MGP_PahariEiJ_G0014745	Smarca4	100	98.894	Mus_pahari
ENSG00000127616	SMARCA4	100	99.625	MGP_SPRETEiJ_G0033003	Smarca4	100	99.526	Mus_spretus
ENSG00000127616	SMARCA4	100	99.752	ENSMPUG00000005711	SMARCA4	100	99.752	Mustela_putorius_furo
ENSG00000127616	SMARCA4	100	99.719	ENSMLUG00000004491	-	100	99.628	Myotis_lucifugus
ENSG00000127616	SMARCA4	100	99.531	ENSNGAG00000021852	Smarca4	100	98.699	Nannospalax_galili
ENSG00000127616	SMARCA4	99	95.652	ENSNBRG00000018865	-	99	80.964	Neolamprologus_brichardi
ENSG00000127616	SMARCA4	99	96.000	ENSNBRG00000011457	smarca4a	96	86.355	Neolamprologus_brichardi
ENSG00000127616	SMARCA4	100	99.363	ENSNLEG00000012389	SMARCA4	100	93.988	Nomascus_leucogenys
ENSG00000127616	SMARCA4	100	95.541	ENSOPRG00000000885	-	75	100.000	Ochotona_princeps
ENSG00000127616	SMARCA4	100	98.330	ENSODEG00000017127	SMARCA4	98	98.246	Octodon_degus
ENSG00000127616	SMARCA4	99	95.652	ENSONIG00000008196	smarca4a	100	88.409	Oreochromis_niloticus
ENSG00000127616	SMARCA4	99	95.652	ENSONIG00000018040	-	100	83.204	Oreochromis_niloticus
ENSG00000127616	SMARCA4	67	89.189	ENSOANG00000029207	-	89	95.541	Ornithorhynchus_anatinus
ENSG00000127616	SMARCA4	100	98.726	ENSOCUG00000001787	SMARCA4	99	91.345	Oryctolagus_cuniculus
ENSG00000127616	SMARCA4	99	95.652	ENSORLG00000003955	-	97	87.446	Oryzias_latipes
ENSG00000127616	SMARCA4	99	95.652	ENSORLG00000015452	smarca4a	100	85.906	Oryzias_latipes
ENSG00000127616	SMARCA4	99	95.652	ENSORLG00020004611	smarca4a	100	85.889	Oryzias_latipes_hni
ENSG00000127616	SMARCA4	99	95.652	ENSORLG00020009728	-	97	87.457	Oryzias_latipes_hni
ENSG00000127616	SMARCA4	99	95.652	ENSORLG00015007739	-	99	82.427	Oryzias_latipes_hsok
ENSG00000127616	SMARCA4	99	95.652	ENSORLG00015016560	smarca4a	100	86.028	Oryzias_latipes_hsok
ENSG00000127616	SMARCA4	99	95.652	ENSOMEG00000007486	smarca4a	100	87.118	Oryzias_melastigma
ENSG00000127616	SMARCA4	99	95.652	ENSOMEG00000016626	-	99	83.553	Oryzias_melastigma
ENSG00000127616	SMARCA4	100	97.452	ENSOGAG00000016148	SMARCA4	100	97.645	Otolemur_garnettii
ENSG00000127616	SMARCA4	100	98.593	ENSOARG00000017454	SMARCA4	100	97.957	Ovis_aries
ENSG00000127616	SMARCA4	100	100.000	ENSPPAG00000043191	SMARCA4	100	100.000	Pan_paniscus
ENSG00000127616	SMARCA4	100	99.757	ENSPPRG00000000064	SMARCA4	100	99.757	Panthera_pardus
ENSG00000127616	SMARCA4	100	99.363	ENSPTIG00000017447	SMARCA4	94	99.517	Panthera_tigris_altaica
ENSG00000127616	SMARCA4	100	100.000	ENSPTRG00000010488	SMARCA4	100	100.000	Pan_troglodytes
ENSG00000127616	SMARCA4	100	100.000	ENSPANG00000011042	SMARCA4	100	99.881	Papio_anubis
ENSG00000127616	SMARCA4	100	100.000	ENSPKIG00000007770	SMARCA4	100	88.200	Paramormyrops_kingsleyae
ENSG00000127616	SMARCA4	100	100.000	ENSPKIG00000010087	-	98	87.147	Paramormyrops_kingsleyae
ENSG00000127616	SMARCA4	97	99.412	ENSPSIG00000005547	SMARCA4	100	91.086	Pelodiscus_sinensis
ENSG00000127616	SMARCA4	100	99.345	ENSPEMG00000020389	Smarca4	100	99.258	Peromyscus_maniculatus_bairdii
ENSG00000127616	SMARCA4	100	99.156	ENSPCIG00000017138	SMARCA4	100	98.884	Phascolarctos_cinereus
ENSG00000127616	SMARCA4	97	100.000	ENSPFOG00000007892	smarca4a	100	86.792	Poecilia_formosa
ENSG00000127616	SMARCA4	99	95.652	ENSPFOG00000012930	-	99	83.562	Poecilia_formosa
ENSG00000127616	SMARCA4	99	95.652	ENSPLAG00000018616	-	81	90.298	Poecilia_latipinna
ENSG00000127616	SMARCA4	99	100.000	ENSPLAG00000014294	smarca4a	100	86.853	Poecilia_latipinna
ENSG00000127616	SMARCA4	99	95.652	ENSPMEG00000008929	-	98	84.721	Poecilia_mexicana
ENSG00000127616	SMARCA4	99	100.000	ENSPMEG00000003725	smarca4a	97	87.636	Poecilia_mexicana
ENSG00000127616	SMARCA4	99	100.000	ENSPREG00000014608	smarca4a	100	86.606	Poecilia_reticulata
ENSG00000127616	SMARCA4	99	95.652	ENSPREG00000014823	-	97	84.220	Poecilia_reticulata
ENSG00000127616	SMARCA4	100	100.000	ENSPPYG00000009568	SMARCA4	100	99.939	Pongo_abelii
ENSG00000127616	SMARCA4	97	100.000	ENSPCAG00000014054	SMARCA4	77	99.383	Procavia_capensis
ENSG00000127616	SMARCA4	100	99.629	ENSPCOG00000023011	SMARCA4	100	99.629	Propithecus_coquereli
ENSG00000127616	SMARCA4	99	100.000	ENSPVAG00000007787	SMARCA4	96	99.247	Pteropus_vampyrus
ENSG00000127616	SMARCA4	99	95.652	ENSPNYG00000000717	smarca4a	96	88.020	Pundamilia_nyererei
ENSG00000127616	SMARCA4	99	95.652	ENSPNYG00000023995	-	97	82.080	Pundamilia_nyererei
ENSG00000127616	SMARCA4	100	94.524	ENSPNAG00000006636	-	97	86.393	Pygocentrus_nattereri
ENSG00000127616	SMARCA4	94	97.260	ENSPNAG00000024136	smarca4a	98	88.024	Pygocentrus_nattereri
ENSG00000127616	SMARCA4	100	99.437	ENSRNOG00000009271	Smarca4	100	99.256	Rattus_norvegicus
ENSG00000127616	SMARCA4	100	99.821	ENSRBIG00000038696	SMARCA4	100	99.821	Rhinopithecus_bieti
ENSG00000127616	SMARCA4	100	99.881	ENSRROG00000045509	SMARCA4	100	99.881	Rhinopithecus_roxellana
ENSG00000127616	SMARCA4	100	100.000	ENSSBOG00000026896	SMARCA4	100	99.820	Saimiri_boliviensis_boliviensis
ENSG00000127616	SMARCA4	100	99.062	ENSSHAG00000001642	SMARCA4	100	98.698	Sarcophilus_harrisii
ENSG00000127616	SMARCA4	99	100.000	ENSSFOG00015013823	smarca4	100	87.485	Scleropages_formosus
ENSG00000127616	SMARCA4	99	100.000	ENSSFOG00015009921	-	91	90.868	Scleropages_formosus
ENSG00000127616	SMARCA4	99	95.652	ENSSMAG00000014082	-	99	82.024	Scophthalmus_maximus
ENSG00000127616	SMARCA4	99	92.795	ENSSMAG00000003200	smarca4a	100	85.619	Scophthalmus_maximus
ENSG00000127616	SMARCA4	99	95.652	ENSSDUG00000005388	-	95	86.849	Seriola_dumerili
ENSG00000127616	SMARCA4	97	100.000	ENSSDUG00000017298	smarca4a	100	83.926	Seriola_dumerili
ENSG00000127616	SMARCA4	99	95.652	ENSSLDG00000024486	smarca4a	100	86.607	Seriola_lalandi_dorsalis
ENSG00000127616	SMARCA4	99	95.652	ENSSLDG00000023663	-	97	87.573	Seriola_lalandi_dorsalis
ENSG00000127616	SMARCA4	94	98.892	ENSSARG00000013477	SMARCA4	85	100.000	Sorex_araneus
ENSG00000127616	SMARCA4	99	95.124	ENSSPUG00000004558	SMARCA4	98	92.482	Sphenodon_punctatus
ENSG00000127616	SMARCA4	99	95.652	ENSSPAG00000004248	smarca4a	100	86.288	Stegastes_partitus
ENSG00000127616	SMARCA4	99	95.833	ENSSPAG00000012533	-	99	83.245	Stegastes_partitus
ENSG00000127616	SMARCA4	100	100.000	ENSSSCG00000013629	SMARCA4	100	99.876	Sus_scrofa
ENSG00000127616	SMARCA4	97	100.000	ENSTGUG00000015488	-	92	99.145	Taeniopygia_guttata
ENSG00000127616	SMARCA4	94	97.260	ENSTRUG00000001378	SMARCA4	98	83.365	Takifugu_rubripes
ENSG00000127616	SMARCA4	99	95.652	ENSTRUG00000004885	smarca4a	100	81.267	Takifugu_rubripes
ENSG00000127616	SMARCA4	97	95.652	ENSTNIG00000004536	SMARCA4	100	83.516	Tetraodon_nigroviridis
ENSG00000127616	SMARCA4	76	95.652	ENSTNIG00000004859	-	100	84.342	Tetraodon_nigroviridis
ENSG00000127616	SMARCA4	64	94.286	ENSTBEG00000000707	-	53	100.000	Tupaia_belangeri
ENSG00000127616	SMARCA4	100	99.363	ENSTTRG00000009519	SMARCA4	100	97.996	Tursiops_truncatus
ENSG00000127616	SMARCA4	100	99.814	ENSUAMG00000014661	SMARCA4	100	99.814	Ursus_americanus
ENSG00000127616	SMARCA4	100	100.000	ENSUMAG00000022005	SMARCA4	99	99.415	Ursus_maritimus
ENSG00000127616	SMARCA4	100	99.752	ENSVVUG00000017820	SMARCA4	97	99.752	Vulpes_vulpes
ENSG00000127616	SMARCA4	97	100.000	ENSXETG00000009355	smarca4	100	86.946	Xenopus_tropicalis
ENSG00000127616	SMARCA4	99	95.652	ENSXCOG00000013494	-	97	81.898	Xiphophorus_couchianus
ENSG00000127616	SMARCA4	99	95.652	ENSXMAG00000007030	-	99	83.782	Xiphophorus_maculatus
ENSG00000127616	SMARCA4	97	100.000	ENSXMAG00000006321	smarca4a	100	86.943	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000122	negative regulation of transcription by RNA polymerase II	17938176.19149898.	TAS	Process
GO:0000790	nuclear chromatin	16217013.	HDA	Component
GO:0000790	nuclear chromatin	12065415.15774904.	IDA	Component
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	16217013.	HDA	Function
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	16217013.	HDA	Function
GO:0001164	RNA polymerase I CORE element sequence-specific DNA binding	22368283.	IDA	Function
GO:0001188	RNA polymerase I preinitiation complex assembly	-	IEA	Process
GO:0002039	p53 binding	11950834.	IPI	Function
GO:0003407	neural retina development	18816825.	IEP	Process
GO:0003713	transcription coactivator activity	15774904.	IDA	Function
GO:0003713	transcription coactivator activity	16687403.	IMP	Function
GO:0003713	transcription coactivator activity	8804307.	NAS	Function
GO:0003714	transcription corepressor activity	18487222.20418909.	IDA	Function
GO:0003723	RNA binding	-	IEA	Function
GO:0004386	helicase activity	-	IEA	Function
GO:0005515	protein binding	10078207.11726552.11780067.11988099.12065415.12192000.12200431.12368262.12917342.14701856.15985610.16051670.16687403.17984088.18303029.19149898.19571879.20224553.20418909.22140357.23022380.23540691.24434208.24550003.28420882.28649782.30108113.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005615	extracellular space	22664934.	HDA	Component
GO:0005634	nucleus	8232556.11726552.20418909.22368283.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005730	nucleolus	22368283.	IDA	Component
GO:0006325	chromatin organization	-	TAS	Process
GO:0006337	nucleosome disassembly	8895581.	IDA	Process
GO:0006338	chromatin remodeling	18816825.	IC	Process
GO:0006338	chromatin remodeling	10943845.11726552.	IDA	Process
GO:0006338	chromatin remodeling	22368283.	IMP	Process
GO:0006357	regulation of transcription by RNA polymerase II	8804307.	NAS	Process
GO:0007399	nervous system development	-	IEA	Process
GO:0008094	DNA-dependent ATPase activity	8232556.	IGI	Function
GO:0008134	transcription factor binding	22368283.	IPI	Function
GO:0016020	membrane	19946888.	HDA	Component
GO:0016514	SWI/SNF complex	8804307.10943845.11078522.29374058.	IDA	Component
GO:0030177	positive regulation of Wnt signaling pathway	19571879.	IMP	Process
GO:0030308	negative regulation of cell growth	12065415.	IMP	Process
GO:0030957	Tat protein binding	16687403.	IPI	Function
GO:0031492	nucleosomal DNA binding	16217013.	HDA	Function
GO:0032991	protein-containing complex	16217013.	HDA	Component
GO:0038111	interleukin-7-mediated signaling pathway	-	TAS	Process
GO:0043044	ATP-dependent chromatin remodeling	16217013.	HDA	Process
GO:0043923	positive regulation by host of viral transcription	16687403.	IMP	Process
GO:0045892	negative regulation of transcription, DNA-templated	12065415.	IDA	Process
GO:0045892	negative regulation of transcription, DNA-templated	18487222.	IMP	Process
GO:0045893	positive regulation of transcription, DNA-templated	8208605.	IMP	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	15774904.17938176.	IDA	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	8232556.	IGI	Process
GO:0047485	protein N-terminus binding	12917342.	IPI	Function
GO:0050681	androgen receptor binding	18487222.	IPI	Function
GO:0051091	positive regulation of DNA-binding transcription factor activity	11950834.17938176.	IDA	Process
GO:0060766	negative regulation of androgen receptor signaling pathway	18487222.	IMP	Process
GO:0070182	DNA polymerase binding	19571879.	IPI	Function
GO:0070577	lysine-acetylated histone binding	17582821.	IDA	Function
GO:0071564	npBAF complex	18816825.	IDA	Component
GO:0071564	npBAF complex	-	ISS	Component
GO:0071565	nBAF complex	-	ISS	Component
GO:1901838	positive regulation of transcription of nucleolar large rRNA by RNA polymerase I	22368283.	IMP	Process
GO:1902661	positive regulation of glucose mediated signaling pathway	22368283.	IDA	Process
GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	25569094.	IMP	Process
GO:1904837	beta-catenin-TCF complex assembly	-	TAS	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
30177679	SCFFBW7-mediated degradation of Brg1 suppresses gastric cancer metastasis.	Nat Commun	2018 Sep 3	Huang LY	doi: 10.1038/s41467-018-06038-y.
18386774	Frequent BRG1/SMARCA4-inactivating mutations in human lung cancer cell lines.	Hum Mutat	2008 May	Medina PP	doi: 10.1002/humu.20730.
28232072	BRG1 and BRM function antagonistically with c-MYC in adult cardiomyocytes to regulate conduction and contractility.	J Mol Cell Cardiol	2017 Apr	Willis MS	doi: 10.1016/j.yjmcc.2017.02.003
22362300	BRG1 expression is increased in human glioma and controls glioma cell proliferation, migration and invasion in vitro.	J Cancer Res Clin Oncol	2012 Jun	Bai J	doi: 10.1007/s00432-012-1172-8
12566296	Loss of BRG1/BRM in human lung cancer cell lines and primary lung cancers: correlation with poor prognosis.	Cancer Res	2003 Feb 1	Reisman DN	-
17075831	Aberrant expression of SWI/SNF catalytic subunits BRG1/BRM is associated with tumor development and increased invasiveness in prostate cancers.	Prostate	2007 Feb 1	Sun A	-
25504753	Targeting BRG1 chromatin remodeler via its bromodomain for enhanced tumor cell radiosensitivity in vitro and in vivo.	Mol Cancer Ther	2015 Feb	Kwon SJ	doi: 10.1158/1535-7163.MCT-14-0372
15887247	BRG1 loss in MiaPaCa2 cells induces an altered cellular morphology and disruption in the organization of the actin cytoskeleton.	J Cell Physiol	2005 Nov	Rosson GB	-
21317927	MicroRNA-21 targets tumor suppressor genes ANP32A and SMARCA4.	Oncogene	2011 Jun 30	Schramedei K	doi: 10.1038/onc.2011.15
21730156	Maintenance of tumor initiating cells of defined genetic composition by nucleostemin.	Proc Natl Acad Sci U S A	2011 Dec 20	Okamoto N	doi: 10.1073/pnas.1015171108
11719516	Compensation of BRG-1 function by Brm: insight into the role of the core SWI-SNF subunits in retinoblastoma tumor suppressor signaling.	J Biol Chem	2002 Feb 15	Strobeck MW	-
11950834	SWI/SNF complex interacts with tumor suppressor p53 and is necessary for the activation of p53-mediated transcription.	J Biol Chem	2002 Jun 21	Lee D	-
27145366	BRG1 targeting STAT3/VEGFC signaling regulates lymphangiogenesis in colorectal cancer.	Oncotarget	2016 Jun 14	Zhu X	doi: 10.18632/oncotarget.9038.
27486753	Mechanism of BRG1 silencing in primary cancers.	Oncotarget	2016 Aug 30	Marquez-Vilendrer SB	doi: 10.18632/oncotarget.10593.
29750276	Thyroid Hormone Receptor β Suppression of RUNX2 Is Mediated by Brahma-Related Gene 1-Dependent Chromatin Remodeling.	Endocrinology	2018 Jun 1	Gillis NE	doi: 10.1210/en.2018-00128.
25115300	BRG1/SMARCA4 inactivation promotes non-small cell lung cancer aggressiveness by altering chromatin organization.	Cancer Res	2014 Nov 15	Orvis T	doi: 10.1158/0008-5472.CAN-14-0061
28899659	BRG1 promotes VEGF-A expression and angiogenesis in human colorectal cancer cells.	Exp Cell Res	2017 Nov 15	Lan J	doi: 10.1016/j.yexcr.2017.09.013
12684665	Mutation analysis of the BRG1 gene in prostate cancer clinical samples.	Int J Oncol	2003 May	Valdman A	-
19448667	The SWI/SNF chromatin remodeling subunit BRG1 is a critical regulator of p53 necessary for proliferation of malignant cells.	Oncogene	2009 Jul 9	Naidu SR	doi: 10.1038/onc.2009.121
25684411	The CRISPR/Cas system inhibited the pro-oncogenic effects of alternatively spliced fibronectin extra domain A via editing the genome in salivary adenoid cystic carcinoma cells.	Oral Dis	2015 Jul	Wang HC	doi: 10.1111/odi.12323
20137775	Germline nonsense mutation and somatic inactivation of SMARCA4/BRG1 in a family with rhabdoid tumor predisposition syndrome.	Am J Hum Genet	2010 Feb 12	Schneppenheim R	doi: 10.1016/j.ajhg.2010.01.013
25808524	The SWI/SNF ATPases Are Required for Triple Negative Breast Cancer Cell Proliferation.	J Cell Physiol	2015 Nov	Wu Q	doi: 10.1002/jcp.24991.
24993775	Long non-coding RNA urothelial carcinoma associated1 induces cell replication by inhibiting BRG1 in 5637 cells.	Oncol Rep	2014 Sep	Wang X	doi: 10.3892/or.2014.3309
28038711	SMARCA4 and SMARCA2 deficiency in non-small cell lung cancer: immunohistochemical survey of 316 consecutive specimens.	Ann Diagn Pathol	2017 Feb	Herpel E	doi: 10.1016/j.anndiagpath.2016.10.006
24362264	MAX inactivation in small cell lung cancer disrupts MYC-SWI/SNF programs and is synthetic lethal with BRG1.	Cancer Discov	2014 Mar	Romero OA	doi: 10.1158/2159-8290.CD-13-0799
23533649	BRG1 is a prognostic marker and potential therapeutic target in human breast cancer.	PLoS One	2013	Bai J	doi: 10.1371/journal.pone.0059772
27630343	Increased Brahma-related Gene 1 Expression Predicts Distant Metastasis and Shorter Survival in Patients with Invasive Ductal Carcinoma of the Breast.	Anticancer Res	2016 Sep	Do SI	-
21092585	[Expression of BRG1 and BRM proteins in prostatic cancer].	Zhonghua Bing Li Xue Za Zhi	2010 Sep	Liu XB	-
23872584	A synthetic lethality-based strategy to treat cancers harboring a genetic deficiency in the chromatin remodeling factor BRG1.	Cancer Res	2013 Sep 1	Oike T	doi: 10.1158/0008-5472.CAN-12-4593
15240517	Chromatin remodeling factors and BRM/BRG1 expression as prognostic indicators in non-small cell lung cancer.	Clin Cancer Res	2004 Jul 1	Fukuoka J	-
22407764	The tumour suppressor and chromatin-remodelling factor BRG1 antagonizes Myc activity and promotes cell differentiation in human cancer.	EMBO Mol Med	2012 Jul	Romero OA	doi: 10.1002/emmm.201200236
27373334	BRCA1/FANCD2/BRG1-Driven DNA Repair Stabilizes the Differentiation State of Human Mammary Epithelial Cells.	Mol Cell	2016 Jul 21	Wang H	doi: 10.1016/j.molcel.2016.05.038
27029062	Targeting the chromatin remodeling enzyme BRG1 increases the efficacy of chemotherapy drugs in breast cancer cells.	Oncotarget	2016 May 10	Wu Q	doi: 10.18632/oncotarget.8384.
27852072	The chromatin-remodeling enzyme BRG1 promotes colon cancer progression via positive regulation of WNT3A.	Oncotarget	2016 Dec 27	Lin S	doi: 10.18632/oncotarget.13326.
27223259	The BRG1 chromatin remodeling enzyme links cancer cell metabolism and proliferation.	Oncotarget	2016 Jun 21	Wu Q	doi: 10.18632/oncotarget.9505.
29423809	Identification of Driver Mutations in Rare Cancers: The Role of SMARCA4 in Small Cell Carcinoma of the Ovary, Hypercalcemic Type (SCCOHT).	Methods Mol Biol	2018	Lang JD	doi: 10.1007/978-1-4939-7471-9_20.
30286321	In silico screening of cancer-associated mutations in the HSA domain of BRG1 and its role in affecting the Arp-HSA sub-complex of SWI/SNF.	Comput Biol Chem	2018 Dec	S AS	doi: 10.1016/j.compbiolchem.2018.07.001
29288038	BRG1 is correlated with poor prognosis in colorectal cancer.	Hum Pathol	2018 Mar	Pyo JS	doi: 10.1016/j.humpath.2017.12.013
29535420	LncFZD6 initiates Wnt/β-catenin and liver TIC self-renewal through BRG1-mediated FZD6 transcriptional activation.	Oncogene	2018 Jun	Chen Z	doi: 10.1038/s41388-018-0203-6

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr19	10986337	Silent	novel	G168G	0.12
ACC	chr19	10986441	Missense_Mutation	rs780497718	A203V	0.38
ACC	chr19	11039525	Intron	NA		0.63
BLCA	chr19	11013101	Silent	rs773895427	I809I	0.46
BLCA	chr19	11034170	Silent	novel	A1307A	0.35
BLCA	chr19	10989374	Frame_Shift_Del	novel	*A393Ifs16**	0.98
BLCA	chr19	11027815	Missense_Mutation	novel	E1083K	0.49
BLCA	chr19	11013031	Missense_Mutation	NA	T786N	0.39
BLCA	chr19	11021840	Missense_Mutation	novel	G911D	0.56
BLCA	chr19	11041444	Missense_Mutation	novel	E1436D	0.66
BLCA	chr19	11021837	Missense_Mutation	NA	T910M	0.17
BLCA	chr19	10987716	Frame_Shift_Del	novel	*P305Rfs21**	0.33
BLCA	chr19	11021754	Missense_Mutation	NA	E882D	0.2
BLCA	chr19	11025439	Missense_Mutation	NA	K1033N	0.22
BLCA	chr19	11030750	Missense_Mutation	rs11537676	R1135W	0.14
BLCA	chr19	11010477	Silent	NA	E740E	0.31
BLCA	chr19	11010479	Missense_Mutation	NA	R741K	0.32
BLCA	chr19	11013050	Silent	rs568699320	L792L	0.49
BLCA	chr19	11041313	Missense_Mutation	rs752264295	E1393K	0.5
BLCA	chr19	10984188	Missense_Mutation	NA	R13W	0.19	ResIII
BLCA	chr19	11033290	Missense_Mutation	novel	D1183H	0.69
BLCA	chr19	11024411	Silent	rs529586298	L1018L	0.25
BLCA	chr19	10986255	Missense_Mutation	novel	S141L	0.26
BLCA	chr19	10994828	Missense_Mutation	novel	E474K	0.11
BLCA	chr19	11025428	Missense_Mutation	novel	G1030C	0.42
BLCA	chr19	11008022	Missense_Mutation	novel	E708Q	0.26
BLCA	chr19	10984249	Missense_Mutation	NA	G33D	0.18
BLCA	chr19	11027919	Frame_Shift_Ins	novel	*R1119Ifs22**	0.04
BLCA	chr19	11058301	Nonsense_Mutation	NA	R1491*	0.29
BLCA	chr19	11033842	Missense_Mutation	rs765989895	D1284N	0.18
BRCA	chr19	11021959	Frame_Shift_Del	novel	*E952Kfs5**	0.19
BRCA	chr19	11059819	Missense_Mutation	NA	D1568N	0.16
BRCA	chr19	11023558	Missense_Mutation	NA	R967H	0.13
BRCA	chr19	11021712	Intron	novel		0.44
BRCA	chr19	11019002	Silent	NA	S828S	0.33
BRCA	chr19	10985297	Missense_Mutation	novel	G83R	0.22
BRCA	chr19	10986371	Missense_Mutation	NA	L180F	0.16
BRCA	chr19	11059852	Nonsense_Mutation	NA	E1579*	0.44
BRCA	chr19	11003076	Silent	NA	I620I	0.37
BRCA	chr19	11021712	Intron	novel		0.17
BRCA	chr19	11030773	Missense_Mutation	NA	F1142L	0.37
BRCA	chr19	10985304	Missense_Mutation	rs751542188	S85L	0.67
BRCA	chr19	11041316	Nonsense_Mutation	novel	E1394*	0.13
BRCA	chr19	11058329	Missense_Mutation	novel	L1500P	0.4
BRCA	chr19	11033318	Missense_Mutation	NA	R1192H	0.23
BRCA	chr19	11010519	Silent	NA	L754L	0.37
BRCA	chr19	11021752	Missense_Mutation	NA	E882K	0.13
BRCA	chr19	11012948	Splice_Site	NA	X759_splice	0.42
CESC	chr19	11060124	Silent	rs370590601	P1616P	0.26
CESC	chr19	11019061	Intron	novel		0.36
CESC	chr19	11019632	Silent	NA	R849R	0.15
CESC	chr19	11034132	Missense_Mutation	novel	E1295K	0.59
CESC	chr19	11041336	Silent	rs577059244	I1400I	0.42
CESC	chr19	10994884	Silent	novel	S492S	0.2
CESC	chr19	11018978	Nonsense_Mutation	NA	Y820*	0.95
CESC	chr19	10996320	Silent	NA	L567L	0.31
CESC	chr19	10996222	Missense_Mutation	NA	E535K	0.44
CESC	chr19	10996509	Missense_Mutation	novel	E593K	0.29
CESC	chr19	10989328	Missense_Mutation	NA	R377H	0.24
CESC	chr19	10991154	Missense_Mutation	novel	R417H	0.44
CESC	chr19	11033400	Silent	novel	K1219K	0.4
CESC	chr19	10996264	Missense_Mutation	NA	R549C	0.15
CESC	chr19	11018954	Splice_Region	novel		0.79
CESC	chr19	10986305	Missense_Mutation	novel	D158Y	0.13
CESC	chr19	11021959	Missense_Mutation	novel	G951R	0.31
CESC	chr19	11060078	Missense_Mutation	NA	R1601Q	0.23
CESC	chr19	11033301	Silent	rs140322802	A1186A	0.2
CESC	chr19	10991242	Silent	rs569040381	S446S	0.57
CESC	chr19	11023575	Missense_Mutation	NA	R973W	0.31
CHOL	chr19	11030832	Missense_Mutation	NA	G1162V	0.05
COAD	chr19	10996542	Missense_Mutation	NA	E604K	0.16
COAD	chr19	10984151	5'UTR	novel		0.35
COAD	chr19	10989340	Missense_Mutation	rs749059769	R381Q	0.41
COAD	chr19	11035013	Missense_Mutation	NA	D1351N	0.19
COAD	chr19	11030751	Frame_Shift_Del	novel	*G1136Afs4**	0.27
COAD	chr19	11033396	Missense_Mutation	novel	A1218V	0.36
COAD	chr19	11035067	Missense_Mutation	NA	R1369S	0.24
COAD	chr19	11030889	Missense_Mutation	novel	H1181P	0.46
COAD	chr19	11013056	Silent	rs373048420	T794T	0.13
COAD	chr19	11033773	Missense_Mutation	novel	H1261Y	0.52
COAD	chr19	10991260	Silent	novel	I452I	0.18
COAD	chr19	11021731	Missense_Mutation	novel	W875R	0.18
COAD	chr19	11027916	Silent	novel	F1116F	0.5
COAD	chr19	10984292	Frame_Shift_Ins	novel	*P49Afs33**	0.24
COAD	chr19	11041491	Frame_Shift_Del	novel	*P1453Lfs10**	0.31
COAD	chr19	10987864	Frame_Shift_Del	NA	*I355Sfs56**	0.42
COAD	chr19	11033300	Missense_Mutation	NA	A1186V	0.4
COAD	chr19	11060109	Silent	rs558890921	G1611G	0.24
COAD	chr19	10994884	Silent	rs528531511	S492S	0.11
COAD	chr19	11033309	Missense_Mutation	NA	R1189Q	0.21
COAD	chr19	11033803	Missense_Mutation	NA	F1271L	0.41
COAD	chr19	10991248	Silent	rs140328531	R448R	0.22
COAD	chr19	10985304	Missense_Mutation	rs751542188	S85L	0.36
COAD	chr19	10996293	Silent	rs147798066	D558D	0.19
COAD	chr19	11013046	Missense_Mutation	NA	A791V	0.22
COAD	chr19	11018994	Frame_Shift_Ins	novel	*S828Lfs117**	0.15
COAD	chr19	11060099	Missense_Mutation	rs375672575	R1608Q	0.09
COAD	chr19	11021761	Missense_Mutation	rs281875227	R885C	0.17
COAD	chr19	10989344	Silent	novel	I382I	0.42
COAD	chr19	11025505	Silent	rs774483875	I1055I	0.34
COAD	chr19	10985372	Frame_Shift_Del	NA	*P109Rfs194**	0.35
COAD	chr19	11035013	Missense_Mutation	NA	D1351N	0.31
COAD	chr19	11035110	Missense_Mutation	novel	L1383P	0.1
COAD	chr19	11021761	Missense_Mutation	rs281875227	R885C	0.38
COAD	chr19	10989328	Missense_Mutation	NA	R377H	0.23
COAD	chr19	11060047	Missense_Mutation	novel	R1591W	0.22
COAD	chr19	10989425	Silent	novel	L409L	0.28
COAD	chr19	11021761	Missense_Mutation	rs281875227	R885C	0.19
COAD	chr19	11035029	Missense_Mutation	NA	R1356Q	0.17
COAD	chr19	11003355	Silent	rs757029847	P653P	0.31
COAD	chr19	10991177	Missense_Mutation	novel	R425W	0.35
COAD	chr19	11030828	Missense_Mutation	NA	L1161F	0.25
COAD	chr19	11007959	Missense_Mutation	rs751565055	K687E	0.4
COAD	chr19	11041465	Silent	rs373999751	R1443R	0.44
DLBC	chr19	11023554	Missense_Mutation	NA	R966W	0.23
ESCA	chr19	11013017	Missense_Mutation	NA	M781I	0.23
ESCA	chr19	11021837	Missense_Mutation	NA	T910M	0.26
ESCA	chr19	11021729	Missense_Mutation	NA	R874H	0.11
ESCA	chr19	11023554	Missense_Mutation	NA	R966W	0.63
ESCA	chr19	11021837	Missense_Mutation	NA	T910M	0.37
ESCA	chr19	11026333	Missense_Mutation	rs765857427	G1068S	0.69
ESCA	chr19	11033470	Missense_Mutation	NA	R1243W	0.33
ESCA	chr19	11033317	Missense_Mutation	NA	R1192C	0.5
ESCA	chr19	10986537	Missense_Mutation	novel	G235D	0.28
ESCA	chr19	11033375	Missense_Mutation	novel	E1211A	0.09
ESCA	chr19	11030822	Frame_Shift_Del	NA	*L1161Sfs3**	0.33
ESCA	chr19	11041469	Missense_Mutation	rs775399739	R1445W	0.67
ESCA	chr19	10989428	Silent	novel	L410L	0.06
GBM	chr19	11034177	Missense_Mutation	novel	E1310K	0.43
GBM	chr19	11021866	Missense_Mutation	NA	E920K	0.39
GBM	chr19	11023601	Missense_Mutation	novel	K981N	0.15
GBM	chr19	11024351	Silent	novel	C998C	0.19
GBM	chr19	11030765	Missense_Mutation	novel	K1140E	0.12
GBM	chr19	11030876	Missense_Mutation	novel	D1177N	0.12
GBM	chr19	11021728	Missense_Mutation	NA	R874C	0.37
GBM	chr19	11025484	Silent	rs778369345	H1048H	0.27
GBM	chr19	10996247	Missense_Mutation	novel	D543A	0.06
HNSC	chr19	10996538	Silent	novel	D602D	0.2
HNSC	chr19	11021759	Missense_Mutation	NA	H884R	0.17
HNSC	chr19	11019040	Intron	novel		0.42
HNSC	chr19	11024415	Missense_Mutation	novel	D1020N	0.4
HNSC	chr19	11021846	Missense_Mutation	rs778175819	P913L	0.14
HNSC	chr19	11027943	Missense_Mutation	novel	R1125S	0.33
HNSC	chr19	11041401	Missense_Mutation	novel	S1422F	0.65
HNSC	chr19	11041305	Splice_Site	novel	X1391_splice	0.3
HNSC	chr19	11033309	Missense_Mutation	NA	R1189Q	0.36
HNSC	chr19	10987805	Silent	rs538345417	P333P	0.14
HNSC	chr19	11003125	Missense_Mutation	novel	G637R	0.27
HNSC	chr19	10991247	Missense_Mutation	NA	R448H	0.13
HNSC	chr19	11021861	Missense_Mutation	novel	L918R	0.18
HNSC	chr19	10994968	Frame_Shift_Ins	novel	*R521Vfs93**	0.13
HNSC	chr19	10994970	Missense_Mutation	novel	R521Q	0.13
HNSC	chr19	11033326	Missense_Mutation	novel	Q1195K	0.19
HNSC	chr19	11030751	Missense_Mutation	NA	R1135Q	0.36
HNSC	chr19	11034177	Nonsense_Mutation	novel	E1310*	0.32
HNSC	chr19	10989348	Missense_Mutation	novel	E384K	0.11
HNSC	chr19	11033436	Silent	rs763218564	A1231A	0.11
HNSC	chr19	11033402	Missense_Mutation	novel	Y1220C	0.15
HNSC	chr19	10994916	Missense_Mutation	novel	A503E	0.35
HNSC	chr19	11030831	Missense_Mutation	NA	G1162C	0.43
HNSC	chr19	10986252	Missense_Mutation	novel	S140Y	0.58
HNSC	chr19	11023594	Missense_Mutation	rs797045981	R979Q	0.28
HNSC	chr19	11035129	Silent	novel	L1389L	0.51
HNSC	chr19	11041365	Missense_Mutation	novel	S1410L	0.61
HNSC	chr19	11021846	Missense_Mutation	rs778175819	P913L	0.21
HNSC	chr19	10996234	Missense_Mutation	NA	R539C	0.26
KIRC	chr19	11021846	Missense_Mutation	NA	P913Q	0.08
KIRC	chr19	11033288	Splice_Site	NA	X1183_splice	0.52
KIRC	chr19	11033470	Missense_Mutation	NA	R1243W	0.14
KIRC	chr19	11003133	Silent	NA	L639L	0.41
KIRC	chr19	10989353	In_Frame_Ins	novel	E386dup	0.29
KIRC	chr19	11033307	Missense_Mutation	novel	D1188E	0.13
KIRC	chr19	11033434	Missense_Mutation	novel	A1231T	0.26
KIRC	chr19	10991301	Frame_Shift_Del	novel	*R466Pfs35**	0.25
KIRC	chr19	11018956	Splice_Site	NA	X813_splice	0.31
KIRC	chr19	11033300	Missense_Mutation	NA	A1186G	0.35
KIRC	chr19	11027947	Missense_Mutation	NA	D1127Y	0.08
KIRC	chr19	10996218	Missense_Mutation	NA	E533D	0.27
KIRC	chr19	10987899	Missense_Mutation	novel	E365Q	0.37
KIRC	chr19	11021837	Missense_Mutation	NA	T910M	0.26
KIRP	chr19	11003083	Nonsense_Mutation	novel	E623*	0.42
KIRP	chr19	11012965	Missense_Mutation	novel	W764S	0.42
KIRP	chr19	11030831	Missense_Mutation	novel	G1162R	0.4
KIRP	chr19	11023610	Silent	NA	V984V	0.18
KIRP	chr19	11033344	Missense_Mutation	novel	V1201L	0.51
KIRP	chr19	11023629	Missense_Mutation	NA	K991E	0.37
KIRP	chr19	11018979	Missense_Mutation	NA	E821K	0.75
KIRP	chr19	11027903	Missense_Mutation	novel	M1112R	0.5
KIRP	chr19	11003105	Missense_Mutation	NA	G630A	0.26
KIRP	chr19	11024416	Missense_Mutation	NA	D1020G	0.33
LGG	chr19	11018959	Missense_Mutation	NA	T814K	0.42
LGG	chr19	11013017	Missense_Mutation	novel	M781I	0.11
LGG	chr19	11033351	Missense_Mutation	rs770680174	R1203H	0.07
LGG	chr19	11033420	In_Frame_Del	novel	K1227del	0.33
LGG	chr19	11030823	Missense_Mutation	novel	G1159E	0.17
LGG	chr19	11033300	Missense_Mutation	NA	A1186V	0.33
LGG	chr19	11013030	Missense_Mutation	novel	T786A	0.14
LGG	chr19	11059857	Silent	novel	E1580E	0.2
LGG	chr19	11021759	Missense_Mutation	NA	H884R	0.32
LGG	chr19	11021758	Missense_Mutation	NA	H884N	0.41
LGG	chr19	10987916	Silent	rs754575023	R370R	0.71
LGG	chr19	11023571	Silent	novel	V971V	0.53
LGG	chr19	11024351	Silent	novel	C998C	0.22
LGG	chr19	11035012	Silent	rs575792225	D1350D	0.53
LGG	chr19	11039488	Intron	novel		0.39
LGG	chr19	10985322	Missense_Mutation	NA	N91S	0.29
LGG	chr19	10987824	Missense_Mutation	rs371214327	A340T	0.63
LGG	chr19	11030877	Missense_Mutation	novel	D1177G	0.15
LGG	chr19	11027804	Missense_Mutation	NA	S1079L	0.5
LGG	chr19	11033445	Missense_Mutation	NA	F1234L	0.25
LGG	chr19	11023611	Missense_Mutation	NA	E985K	0.38
LGG	chr19	11033318	Missense_Mutation	NA	R1192H	0.33
LGG	chr19	11024415	Missense_Mutation	NA	D1020Y	0.32
LGG	chr19	11021839	Missense_Mutation	novel	G911C	0.37
LIHC	chr19	11021839	Missense_Mutation	NA	G911S	0.36
LIHC	chr19	11027908	Missense_Mutation	novel	D1114N	0.19
LIHC	chr19	10991231	Missense_Mutation	NA	K443Q	0.38
LIHC	chr19	11035120	Missense_Mutation	novel	K1386N	0.34
LIHC	chr19	11026334	Missense_Mutation	NA	G1068V	0.11
LIHC	chr19	11030826	Missense_Mutation	NA	G1160E	0.63
LIHC	chr19	11033294	Missense_Mutation	novel	L1184P	0.42
LIHC	chr19	11033318	Missense_Mutation	NA	R1192H	0.24
LIHC	chr19	10986187	Splice_Site	NA	X119_splice	0.74
LIHC	chr19	11033317	Missense_Mutation	NA	R1192C	0.47
LUAD	chr19	11013113	Splice_Site	NA	X813_splice	0.36
LUAD	chr19	11013025	Missense_Mutation	novel	G784V	0.56
LUAD	chr19	10994931	Missense_Mutation	novel	H508P	0.25
LUAD	chr19	11041548	Missense_Mutation	NA	K1471R	0.33
LUAD	chr19	10986941	Missense_Mutation	rs371045201	S266L	0.23
LUAD	chr19	10991249	Missense_Mutation	novel	E449K	0.22
LUAD	chr19	11025465	Missense_Mutation	NA	L1042P	0.46
LUAD	chr19	10996333	Frame_Shift_Del	novel	*K572Gfs75**	0.55
LUAD	chr19	11024424	Missense_Mutation	NA	E1023Q	0.5
LUAD	chr19	11034147	Missense_Mutation	novel	E1300K	0.14
LUAD	chr19	10994828	Nonsense_Mutation	NA	E474*	0.11
LUAD	chr19	11027941	Missense_Mutation	NA	R1125G	0.22
LUAD	chr19	11033437	Missense_Mutation	NA	G1232S	0.15
LUAD	chr19	11033499	Silent	novel	E1252E	0.36
LUAD	chr19	10996227	Frame_Shift_Del	novel	*Y538Tfs75**	0.38
LUAD	chr19	11033355	Silent	novel	L1204L	0.2
LUAD	chr19	11035046	Missense_Mutation	novel	E1362K	0.5
LUAD	chr19	11034979	Missense_Mutation	novel	E1339D	0.36
LUAD	chr19	11034980	Nonsense_Mutation	novel	E1340*	0.36
LUAD	chr19	11061788	Missense_Mutation	novel	R1639L	0.08
LUAD	chr19	11021762	Missense_Mutation	novel	R885L	0.17
LUAD	chr19	11021869	Missense_Mutation	rs281875228	L921F	0.27
LUAD	chr19	10996533	Frame_Shift_Del	novel	*P601Rfs12**	0.36
LUAD	chr19	11030870	Missense_Mutation	novel	D1175Y	0.57
LUAD	chr19	11034977	Nonsense_Mutation	NA	E1339*	0.29
LUAD	chr19	11033487	Missense_Mutation	NA	Q1248H	0.2
LUAD	chr19	11019624	Nonsense_Mutation	NA	Q847*	0.71
LUAD	chr19	11021761	Missense_Mutation	rs281875227	R885C	0.48
LUAD	chr19	11019590	Splice_Site	novel	X836_splice	0.58
LUAD	chr19	11033437	Missense_Mutation	NA	G1232S	0.13
LUAD	chr19	11025432	Missense_Mutation	NA	G1031V	0.11
LUAD	chr19	10986954	Silent	rs375413993	P270P	0.33
LUAD	chr19	11003392	Nonsense_Mutation	novel	E666*	0.15
LUAD	chr19	11033473	Missense_Mutation	novel	R1244G	0.17
LUAD	chr19	11058307	Nonsense_Mutation	NA	E1493*	0.49
LUAD	chr19	10996250	Missense_Mutation	NA	Q544P	0.26
LUAD	chr19	11033289	Splice_Site	novel	X1183_splice	0.68
LUAD	chr19	11058354	Missense_Mutation	novel	K1508N	0.43
LUAD	chr19	10994966	Nonsense_Mutation	NA	E520*	0.43
LUAD	chr19	11059855	Nonsense_Mutation	NA	E1580*	0.59
LUAD	chr19	11027911	Nonsense_Mutation	novel	Y1115*	0.46
LUAD	chr19	11010379	Splice_Site	novel	X708_splice	0.72
LUAD	chr19	11058871	Silent	NA	F1539F	0.34
LUAD	chr19	11007911	Nonsense_Mutation	NA	E671*	0.25
LUAD	chr19	11018955	Splice_Site	NA	X813_splice	0.3
LUAD	chr19	11025421	Splice_Site	NA	X1028_splice	0.25
LUAD	chr19	11027815	Nonsense_Mutation	NA	E1083*	0.55
LUAD	chr19	11030823	Missense_Mutation	novel	G1159A	0.25
LUAD	chr19	11033399	Missense_Mutation	novel	K1219M	0.29
LUAD	chr19	11021737	Nonsense_Mutation	novel	Y877*	0.32
LUAD	chr19	11033438	Missense_Mutation	novel	G1232V	0.17
LUAD	chr19	11030870	Missense_Mutation	NA	D1175N	0.55
LUAD	chr19	10989339	Nonsense_Mutation	NA	R381*	0.17
LUAD	chr19	11030831	Missense_Mutation	NA	G1162C	0.55
LUAD	chr19	11033327	Missense_Mutation	NA	Q1195L	0.08
LUSC	chr19	11019666	Missense_Mutation	NA	E861K	0.24
LUSC	chr19	10985377	Silent	novel	P109P	0.14
LUSC	chr19	11003371	Nonsense_Mutation	NA	E659*	0.48
LUSC	chr19	11019619	Frame_Shift_Del	novel	*V845Afs13**	0.21
LUSC	chr19	11033309	Missense_Mutation	novel	R1189L	0.4
LUSC	chr19	11061842	3'UTR	rs142750187		0.16
LUSC	chr19	11030848	Frame_Shift_Del	novel	*A1168Qfs4**	0.33
LUSC	chr19	11013018	Missense_Mutation	novel	G782C	0.94
LUSC	chr19	10985376	Missense_Mutation	rs763471007	P109L	0.12
LUSC	chr19	10985406	Splice_Site	NA	X119_splice	0.7
LUSC	chr19	11013098	Silent	novel	I808I	0.67
LUSC	chr19	11035019	Nonsense_Mutation	novel	E1353*	0.29
LUSC	chr19	11033467	Missense_Mutation	novel	E1242K	0.21
LUSC	chr19	10984185	Missense_Mutation	NA	P12S	0.18	ResIII
LUSC	chr19	10984186	Missense_Mutation	NA	P12L	0.18	ResIII
LUSC	chr19	11018984	Silent	novel	F822F	0.34
LUSC	chr19	10986296	Frame_Shift_Ins	novel	*D155Efs4**	0.44
LUSC	chr19	11030751	Missense_Mutation	novel	R1135P	0.44
LUSC	chr19	11030876	Missense_Mutation	NA	D1177Y	0.37
LUSC	chr19	11007980	Missense_Mutation	NA	D694Y	0.1
LUSC	chr19	10991307	Missense_Mutation	novel	R468L	0.42
LUSC	chr19	10996526	Silent	novel	A598A	0.91
LUSC	chr19	10994970	Missense_Mutation	NA	R521P	0.86
MESO	chr19	11033317	Missense_Mutation	NA	R1192C	0.72
OV	chr19	11034124	Missense_Mutation	novel	E1292G	0.13
OV	chr19	11030778	Missense_Mutation	novel	E1144A	0.1
OV	chr19	10986214	Silent	novel	S127S	0.09
OV	chr19	11018959	Missense_Mutation	NA	T814K	0.2
OV	chr19	11007959	Missense_Mutation	rs751565055	K687E	0.42
OV	chr19	10996501	Missense_Mutation	novel	E590G	0.09
OV	chr19	11030902	Intron	novel		0.16
OV	chr19	11003386	Frame_Shift_Ins	novel	*E664Gfs44**	0.16
OV	chr19	11027892	Silent	NA	L1108L	0.29
OV	chr19	11033492	Frame_Shift_Del	novel	*I1250Tfs41**	0.04
OV	chr19	11023554	Missense_Mutation	NA	R966W	0.64
OV	chr19	11033366	Missense_Mutation	novel	N1208T	0.2
OV	chr19	10989382	Missense_Mutation	novel	D395A	0.14
OV	chr19	10994836	Silent	NA	L476L	0.28
OV	chr19	10985397	Missense_Mutation	novel	H116L	0.31
OV	chr19	10985353	Silent	novel	G101G	0.07
PAAD	chr19	10994969	Missense_Mutation	NA	R521W	0.18
PAAD	chr19	10996341	Silent	novel	A574A	0.19
PAAD	chr19	11023590	Nonsense_Mutation	NA	R978*	0.2
PAAD	chr19	11033470	Missense_Mutation	NA	R1243W	0.03
PAAD	chr19	11041438	Silent	rs146747026	D1434D	0.19
PAAD	chr19	11059800	Silent	novel	R1561R	0.2
PAAD	chr19	11059833	Silent	novel	G1572G	0.23
PAAD	chr19	11061952	3'UTR	novel		0.12
PAAD	chr19	11033318	Missense_Mutation	NA	R1192H	0.04
PCPG	chr19	11025448	Missense_Mutation	novel	M1036I	0.1
PRAD	chr19	11033383	Missense_Mutation	novel	I1214L	0.29
PRAD	chr19	11007992	Missense_Mutation	novel	V698I	0.42
PRAD	chr19	11012998	Missense_Mutation	novel	G775D	0.36
PRAD	chr19	11033841	Silent	novel	P1283P	0.41
READ	chr19	11033341	Missense_Mutation	NA	R1200C	0.31
READ	chr19	11041324	Silent	rs199847974	T1396T	0.44
READ	chr19	10986408	Frame_Shift_Del	novel	*Q194Sfs109**	0.15
READ	chr19	11033317	Missense_Mutation	NA	R1192C	0.16
READ	chr19	10986233	Missense_Mutation	novel	V134I	0.32
READ	chr19	11019661	Missense_Mutation	rs281875226	T859M	0.63
READ	chr19	10996356	Missense_Mutation	novel	E579D	0.23
SARC	chr19	10984192	Missense_Mutation	novel	P14L	0.51	ResIII
SKCM	chr19	10986973	Missense_Mutation	rs767947665	P277S	0.33
SKCM	chr19	11033316	Silent	novel	H1191H	0.42
SKCM	chr19	11033317	Missense_Mutation	NA	R1192C	0.41
SKCM	chr19	11003061	Silent	novel	L615L	0.2
SKCM	chr19	11007938	Missense_Mutation	novel	P680S	0.29
SKCM	chr19	11041539	Missense_Mutation	NA	A1468V	0.29
SKCM	chr19	11058872	Missense_Mutation	novel	N1540H	0.45
SKCM	chr19	11021957	Missense_Mutation	novel	T950I	0.35
SKCM	chr19	11013012	Missense_Mutation	NA	E780K	0.37
SKCM	chr19	10986964	Missense_Mutation	NA	G274S	0.28
SKCM	chr19	11003097	Silent	NA	I627I	0.2
SKCM	chr19	11013028	Missense_Mutation	NA	K785R	0.29
SKCM	chr19	11023590	Nonsense_Mutation	NA	R978*	0.63
SKCM	chr19	11035063	Silent	rs772075876	F1367F	0.3
SKCM	chr19	11024359	Missense_Mutation	novel	S1001F	0.34
SKCM	chr19	11059880	Missense_Mutation	rs373858447	S1588F	0.26
SKCM	chr19	11019583	Splice_Region	novel		0.33
SKCM	chr19	11019584	Splice_Region	novel		0.33
SKCM	chr19	11039549	Intron	novel		0.14
SKCM	chr19	10984217	Silent	NA	P22P	0.59
SKCM	chr19	10996535	Silent	rs751166438	P601P	0.36
SKCM	chr19	10996537	Missense_Mutation	novel	D602G	0.37
SKCM	chr19	11019666	Missense_Mutation	NA	E861K	0.39
SKCM	chr19	11021889	Silent	NA	F927F	0.56
SKCM	chr19	11059809	Silent	rs746415437	I1564I	0.33
SKCM	chr19	11058341	Missense_Mutation	NA	P1504L	0.08
SKCM	chr19	11041388	Missense_Mutation	rs761083981	D1418N	0.5
SKCM	chr19	11041546	Silent	NA	I1470I	0.27
SKCM	chr19	10986397	Silent	NA	K188K	0.21
SKCM	chr19	10989364	Missense_Mutation	NA	P389L	0.34
SKCM	chr19	11023576	Missense_Mutation	NA	R973Q	0.12
SKCM	chr19	11034167	Silent	rs773151387	I1306I	0.44
SKCM	chr19	11041344	Missense_Mutation	NA	E1403G	0.25
SKCM	chr19	11041539	Missense_Mutation	NA	A1468V	0.34
SKCM	chr19	11058341	Missense_Mutation	NA	P1504L	0.15
SKCM	chr19	11023575	Missense_Mutation	NA	R973W	0.27
SKCM	chr19	11033312	Missense_Mutation	novel	A1190V	0.48
SKCM	chr19	10994956	Silent	NA	K516K	0.42
SKCM	chr19	10986937	Missense_Mutation	NA	P265S	0.3
SKCM	chr19	11019608	Missense_Mutation	novel	R841S	0.27
SKCM	chr19	10986951	Silent	novel	P269P	0.47
SKCM	chr19	10986952	Missense_Mutation	NA	P270S	0.47
SKCM	chr19	11012975	Silent	NA	S767S	0.37
SKCM	chr19	11021752	Missense_Mutation	NA	E882K	0.29
SKCM	chr19	11034992	Missense_Mutation	NA	P1344S	0.38
SKCM	chr19	10991308	Silent	novel	R468R	0.25
SKCM	chr19	10991309	Missense_Mutation	NA	R469W	0.25
SKCM	chr19	11023535	Silent	NA	E959E	0.39
SKCM	chr19	10987822	Missense_Mutation	NA	P339L	0.33
SKCM	chr19	11041406	Missense_Mutation	NA	P1424S	0.3
SKCM	chr19	11030750	Missense_Mutation	rs11537676	R1135W	0.33
SKCM	chr19	11007905	Missense_Mutation	NA	E669K	0.31
SKCM	chr19	10991290	Silent	NA	I462I	0.17
SKCM	chr19	11021752	Missense_Mutation	NA	E882K	0.42
SKCM	chr19	11023591	Missense_Mutation	NA	R978Q	0.43
SKCM	chr19	11030885	Missense_Mutation	NA	P1180S	0.71
STAD	chr19	11033323	Missense_Mutation	NA	G1194R	0.21
STAD	chr19	10986949	Frame_Shift_Del	NA	*M272Cfs31**	0.13
STAD	chr19	10986995	Missense_Mutation	NA	W284L	0.17
STAD	chr19	11027919	Silent	rs781587481	A1117A	0.19
STAD	chr19	11034985	Silent	rs372329621	D1341D	0.23
STAD	chr19	10986955	Missense_Mutation	rs769414440	G271R	0.12
STAD	chr19	11041367	Missense_Mutation	rs755455174	R1411W	0.25
STAD	chr19	11024352	Missense_Mutation	NA	D999N	0.24
STAD	chr19	11033806	Missense_Mutation	rs776672640	A1272T	0.47
STAD	chr19	11058853	Silent	novel	C1533C	0.35
STAD	chr19	11035108	Silent	rs767883680	S1382S	0.35
STAD	chr19	11003105	Missense_Mutation	rs749533909	G630D	0.1
STAD	chr19	11010482	Missense_Mutation	NA	V742A	0.1
STAD	chr19	11024362	Missense_Mutation	NA	A1002V	0.21
STAD	chr19	11058797	Missense_Mutation	NA	R1515C	0.16
STAD	chr19	11021866	Missense_Mutation	NA	E920K	0.23
STAD	chr19	11024403	Missense_Mutation	rs770969438	V1016M	0.3
STAD	chr19	11023576	Missense_Mutation	NA	R973Q	0.87
STAD	chr19	11027918	Missense_Mutation	rs755069412	A1117V	0.08
STAD	chr19	11033317	Missense_Mutation	NA	R1192C	0.47
STAD	chr19	11013018	Missense_Mutation	NA	G782S	0.14
STAD	chr19	11033300	Missense_Mutation	NA	A1186V	0.27
STAD	chr19	11027845	Nonsense_Mutation	NA	R1093*	0.61
STAD	chr19	11030751	Missense_Mutation	NA	R1135Q	0.35
STAD	chr19	11010423	Missense_Mutation	NA	Q722H	0.16
STAD	chr19	11013017	Missense_Mutation	NA	M781I	0.11
STAD	chr19	10986928	Missense_Mutation	NA	P262S	0.45
STAD	chr19	10996535	Silent	rs751166438	P601P	0.3
STAD	chr19	11018975	Silent	rs368438634	A819A	0.07
STAD	chr19	11024344	Missense_Mutation	NA	I996S	0.19
STAD	chr19	11021837	Missense_Mutation	NA	T910M	0.32
STAD	chr19	10986266	Missense_Mutation	NA	M145L	0.33
STAD	chr19	10989388	Missense_Mutation	NA	R397Q	0.34
STAD	chr19	11033823	Silent	rs371304615	P1277P	0.55
STAD	chr19	10996335	Splice_Site	novel	X573_splice	0.46
STAD	chr19	11033822	Missense_Mutation	rs746219091	P1277L	0.38
STAD	chr19	11021837	Missense_Mutation	NA	T910M	0.15
STAD	chr19	11021805	Silent	rs373267815	T899T	0.26
STAD	chr19	11007979	Silent	NA	P693P	0.24
STAD	chr19	11033437	Missense_Mutation	NA	G1232S	0.34
STAD	chr19	11019099	Intron	novel		0.33
TGCT	chr19	11034153	Missense_Mutation	novel	V1302F	0.05
THCA	chr19	11019048	Intron	novel		0.07
THCA	chr19	10984214	Silent	novel	G21G	0.26
THYM	chr19	11030730	Missense_Mutation	novel	G1128V	0.27
THYM	chr19	11003099	Missense_Mutation	novel	L628P	0.05
THYM	chr19	11021837	Missense_Mutation	NA	T910M	0.33
THYM	chr19	11030817	Missense_Mutation	NA	R1157Q	0.2
UCEC	chr19	11013099	Missense_Mutation	novel	I809V	0.21
UCEC	chr19	11013076	Missense_Mutation	NA	R801H	0.42
UCEC	chr19	11041451	Missense_Mutation	NA	K1439Q	0.39
UCEC	chr19	11058325	Missense_Mutation	novel	E1499K	0.18
UCEC	chr19	11025472	Missense_Mutation	novel	K1044N	0.11
UCEC	chr19	11030951	Intron	novel		0.42
UCEC	chr19	11033318	Missense_Mutation	NA	R1192H	0.23
UCEC	chr19	11030874	Missense_Mutation	novel	S1176I	0.39
UCEC	chr19	11062013	3'UTR	novel		0.11
UCEC	chr19	11035120	Silent	NA	K1386K	0.47
UCEC	chr19	11021821	Missense_Mutation	NA	R905C	0.42
UCEC	chr19	11010532	Splice_Site	NA	X758_splice	0.33
UCEC	chr19	10991154	Missense_Mutation	novel	R417H	0.42
UCEC	chr19	10996520	Silent	rs148055156	T596T	0.48
UCEC	chr19	11021387	Intron	novel		0.47
UCEC	chr19	11059782	Silent	novel	S1555S	0.07
UCEC	chr19	10986284	Missense_Mutation	NA	G151S	0.18
UCEC	chr19	11033374	Missense_Mutation	NA	E1211K	0.34
UCEC	chr19	11035034	Missense_Mutation	novel	T1358A	0.34
UCEC	chr19	10985333	Nonsense_Mutation	novel	G95*	0.07
UCEC	chr19	11041337	Missense_Mutation	rs756924224	E1401K	0.35
UCEC	chr19	11033334	Silent	rs377275724	N1197N	0.21
UCEC	chr19	11003037	Silent	rs150138332	D607D	0.38
UCEC	chr19	11003104	Missense_Mutation	novel	G630S	0.58
UCEC	chr19	11035018	Silent	rs765686829	A1352A	0.37
UCEC	chr19	10994974	Silent	novel	I522I	0.46
UCEC	chr19	11012972	Silent	rs746791185	V766V	0.41
UCEC	chr19	10994941	Silent	novel	T511T	0.39
UCEC	chr19	11031015	Intron	novel		0.38
UCEC	chr19	10996376	Missense_Mutation	novel	K586T	0.23
UCEC	chr19	11025448	Missense_Mutation	rs1801514	M1036I	0.09
UCEC	chr19	10991301	Missense_Mutation	NA	R466H	0.19
UCEC	chr19	11007955	Missense_Mutation	novel	E685D	0.42
UCEC	chr19	11021866	Missense_Mutation	NA	E920K	0.36
UCEC	chr19	11025430	Silent	rs778603170	G1030G	0.26
UCEC	chr19	11035060	Missense_Mutation	rs763586264	M1366I	0.27
UCEC	chr19	10991249	Missense_Mutation	novel	E449K	0.57
UCEC	chr19	11003087	Missense_Mutation	novel	S624I	0.41
UCEC	chr19	11010399	Silent	rs748567373	V714V	0.4
UCEC	chr19	11039503	Intron	rs587778686		0.36
UCEC	chr19	11062155	3'Flank	rs546811966		0.44
UCEC	chr19	11024362	Missense_Mutation	NA	A1002V	0.31
UCEC	chr19	11041368	Missense_Mutation	NA	R1411Q	0.18
UCEC	chr19	11041429	Silent	rs149670457	R1431R	0.42
UCEC	chr19	11058342	Silent	rs145435121	P1504P	0.3
UCEC	chr19	10996540	Missense_Mutation	novel	G603V	0.47
UCEC	chr19	11012955	Missense_Mutation	novel	G761C	0.32
UCEC	chr19	11034967	Silent	rs541930013	P1335P	0.47
UCEC	chr19	11041408	Silent	rs114882905	P1424P	0.5
UCEC	chr19	10986949	Frame_Shift_Del	NA	*M272Cfs31**	0.31
UCEC	chr19	11023586	Missense_Mutation	novel	L976F	0.36
UCEC	chr19	11033437	Missense_Mutation	NA	G1232S	0.11
UCEC	chr19	11041465	Silent	rs373999751	R1443R	0.46
UCEC	chr19	11021790	Silent	NA	T894T	0.38
UCEC	chr19	11027942	Missense_Mutation	NA	R1125M	0.43
UCEC	chr19	11039543	Intron	rs775807962		0.46
UCEC	chr19	11033505	Missense_Mutation	novel	E1254D	0.46
UCEC	chr19	11062056	3'UTR	novel		0.45
UCEC	chr19	11058813	Missense_Mutation	NA	R1520H	0.42
UCEC	chr19	10989445	Splice_Site	novel	X415_splice	0.33
UCEC	chr19	10994946	Missense_Mutation	NA	R513Q	0.22
UCEC	chr19	11010400	Missense_Mutation	novel	D715N	0.32
UCEC	chr19	11021680	Intron	novel		0.32
UCEC	chr19	11021888	Missense_Mutation	novel	F927S	0.33
UCEC	chr19	11041499	Missense_Mutation	novel	P1455S	0.45
UCEC	chr19	11021925	Silent	rs147791182	F939F	0.09
UCEC	chr19	10987914	Missense_Mutation	NA	R370C	0.5
UCEC	chr19	11027798	Missense_Mutation	novel	R1077Q	0.2
UCEC	chr19	11059809	Silent	rs746415437	I1564I	0.16
UCEC	chr19	11062021	3'UTR	novel		0.2
UCEC	chr19	10989340	Missense_Mutation	rs749059769	R381Q	0.36
UCEC	chr19	11030742	Missense_Mutation	novel	A1132V	0.39
UCEC	chr19	11033437	Missense_Mutation	NA	G1232S	0.51
UCEC	chr19	11010399	Silent	rs748567373	V714V	0.49
UCEC	chr19	11024351	Silent	novel	C998C	0.61
UCEC	chr19	11033369	Missense_Mutation	rs145476154	S1209N	0.3
UCEC	chr19	11035028	Missense_Mutation	novel	R1356W	0.07
UCEC	chr19	11030848	Silent	rs201875199	S1167S	0.23
UCEC	chr19	11033386	Missense_Mutation	novel	L1215I	0.3
UCEC	chr19	11058798	Missense_Mutation	novel	R1515H	0.44
UCEC	chr19	11019596	Silent	novel	S837S	0.39
UCEC	chr19	10985371	Silent	novel	G107G	0.2
UCEC	chr19	11012996	Silent	rs528157497	N774N	0.38
UCEC	chr19	10989340	Missense_Mutation	rs749059769	R381Q	0.38
UCEC	chr19	10984350	Missense_Mutation	novel	D67N	0.21
UCEC	chr19	11019515	Intron	novel		0.35
UCEC	chr19	10984289	Silent	novel	S46S	0.3
UCEC	chr19	11003131	Missense_Mutation	novel	L639M	0.39
UCEC	chr19	10994998	Silent	NA	L530L	0.44
UCEC	chr19	10986948	Frame_Shift_Ins	novel	*G271Rfs16**	0.34
UCEC	chr19	10994969	Missense_Mutation	NA	R521W	0.43
UCEC	chr19	11024339	Nonsense_Mutation	novel	Y994*	0.75
UCEC	chr19	10985316	Missense_Mutation	novel	R89H	0.16
UCEC	chr19	11027924	Missense_Mutation	rs370466670	R1119H	0.28
UCEC	chr19	11058860	Missense_Mutation	NA	A1536T	0.49
UCEC	chr19	11058813	Missense_Mutation	NA	R1520H	0.17
UCEC	chr19	11021866	Missense_Mutation	NA	E920K	0.32
UCEC	chr19	11024403	Missense_Mutation	rs770969438	V1016M	0.29
UCEC	chr19	11033470	Missense_Mutation	NA	R1243W	0.28
UCEC	chr19	11021361	Intron	novel		0.5
UCEC	chr19	11035052	Missense_Mutation	NA	E1364K	0.38
UCEC	chr19	10986274	Silent	rs201372858	S147S	0.33
UCEC	chr19	10991263	Silent	novel	T453T	0.33
UCEC	chr19	10986949	Frame_Shift_Del	NA	*M272Cfs31**	0.23
UCEC	chr19	11012979	In_Frame_Ins	novel	N772dup	0.32
UCEC	chr19	11027883	Missense_Mutation	NA	M1105I	0.4
UCEC	chr19	10996302	Silent	NA	V561V	0.37
UCEC	chr19	11041336	Silent	rs577059244	I1400I	0.38
UCEC	chr19	10989407	Missense_Mutation	novel	E403D	0.21
UCEC	chr19	11012778	Intron	novel		0.29
UCEC	chr19	11013031	Missense_Mutation	novel	T786I	0.33
UCEC	chr19	11027924	Missense_Mutation	rs370466670	R1119H	0.36
UCEC	chr19	11021944	Missense_Mutation	novel	P946S	0.38
UCEC	chr19	11033355	Silent	novel	L1204L	0.55
UCEC	chr19	11030831	Missense_Mutation	NA	G1162S	0.43
UCEC	chr19	11007971	Missense_Mutation	novel	P691A	0.32
UCEC	chr19	11027883	Missense_Mutation	NA	M1105I	0.33
UCEC	chr19	11010399	Silent	rs748567373	V714V	0.36
UCEC	chr19	11031009	Intron	novel		0.34
UCEC	chr19	11033300	Missense_Mutation	NA	A1186V	0.61
UCEC	chr19	11034940	Missense_Mutation	novel	E1326D	0.29
UCS	chr19	11060098	Missense_Mutation	novel	R1608W	0.3
UCS	chr19	11003391	Missense_Mutation	novel	E665D	0.18
UCS	chr19	11030857	Frame_Shift_Del	novel	*V1171Dfs4**	0.9
UVM	chr19	11021837	Missense_Mutation	NA	T910M	0.72

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
LUAD	DEL	0.3895	1.6249e-05
PAAD	DEL	0.1033	0.0063465
READ	DEL	0.0788	0.23023
THCA	DEL	0.014	0.10598

Survival Analysis

Cancer	P-value	Q-value
THYM	0.033	Kaplan-Meier Survival Analysis
STAD	0.0099	Kaplan-Meier Survival Analysis
SARC	0.009	Kaplan-Meier Survival Analysis
MESO	0.0052	Kaplan-Meier Survival Analysis
ACC	0.0001	Kaplan-Meier Survival Analysis
HNSC	0.025	Kaplan-Meier Survival Analysis
SKCM	0.00011	Kaplan-Meier Survival Analysis
PRAD	0.016	Kaplan-Meier Survival Analysis
ESCA	0.0049	Kaplan-Meier Survival Analysis
KICH	0.01	Kaplan-Meier Survival Analysis
UCEC	0.0064	Kaplan-Meier Survival Analysis
LIHC	0.0066	Kaplan-Meier Survival Analysis
DLBC	0.046	Kaplan-Meier Survival Analysis
LGG	0.035	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742