EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000127804 (Gene tree)
Gene ID: 79066
Gene Symbol: METTL16
Alias: MGC3329|METT10D
Full Name: methyltransferase like 16
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 106,345 bases
Position: chr17:2,405,562-2,511,906
Accession: 28484
RBP type: canonical RBP
Summary: (Methyltransferase Like 16) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include 23S rRNA (adenine(1618)-N(6))-methyltransferase activity.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000263092	MTS	PF05175.14	0.00013	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
29593291	Structural insights into the RNA methyltransferase domain of METTL16.	Sci Rep	2018 Mar 28	Ruszkowska A	doi: 10.1038/s41598-018-23608-8.
30197299	Methylation of Structured RNA by the m6A Writer METTL16 Is Essential for Mouse Embryonic Development.	Mol Cell	2018 Sep 20	Mendel M	doi: 10.1016/j.molcel.2018.08.004
30894375	The Critical Role of RNA m6A Methylation in Cancer.	Cancer Res	2019 Apr 1	Lan Q	doi: 10.1158/0008-5472.CAN-18-2965

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000577148	METTL16-210	554	-	-	- (aa)	-	-
ENST00000576556	METTL16-208	1944	-	ENSP00000460775	121 (aa)	-	I3L3W3
ENST00000263092	METTL16-201	5711	XM_005256801	ENSP00000263092	562 (aa)	XP_005256858	Q86W50
ENST00000381977	METTL16-202	490	-	-	- (aa)	-	-
ENST00000571332	METTL16-204	2644	-	-	- (aa)	-	-
ENST00000574623	METTL16-206	759	-	-	- (aa)	-	-
ENST00000574752	METTL16-207	1602	-	ENSP00000460207	168 (aa)	-	I3L362
ENST00000571669	METTL16-205	5606	-	-	- (aa)	-	-
ENST00000576976	METTL16-209	575	-	ENSP00000461546	148 (aa)	-	I3L4V1
ENST00000571298	METTL16-203	624	-	ENSP00000465733	101 (aa)	-	K7EKQ8

Gene Model

Click here to download ENSG00000127804's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000127804	Macular Degeneration	6.050132E-6	-
ENSG00000127804	Macular Degeneration	6.703E-6	-
ENSG00000127804	Stroke	2.3993062E-004	19369658
ENSG00000127804	Cholesterol, HDL	2.03e-005	19060910
ENSG00000127804	Cholesterol, HDL	3.061e-005	19060910
ENSG00000127804	Cholesterol, HDL	2.33e-007	19060910
ENSG00000127804	Cholesterol, HDL	8.354e-007	19060910
ENSG00000127804	Platelet Function Tests	1.8035500E-005	-
ENSG00000127804	Cholesterol, HDL	2E-7	19060910

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000127804	rs62067054	17	2407317	?	Mean corpuscular hemoglobin	30595370			EFO_0004527

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000127804's network

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000127804	METTL16	98	93.297	ENSAMEG00000007516	METTL16	93	93.297	Ailuropoda_melanoleuca
ENSG00000127804	METTL16	100	94.128	ENSANAG00000032804	METTL16	99	94.128	Aotus_nancymaae
ENSG00000127804	METTL16	98	78.049	ENSACLG00000020590	mettl16	98	64.510	Astatotilapia_calliptera
ENSG00000127804	METTL16	98	75.000	ENSBTAG00000050157	-	87	78.571	Bos_taurus
ENSG00000127804	METTL16	98	93.902	ENSBTAG00000017440	METTL16	87	91.250	Bos_taurus
ENSG00000127804	METTL16	92	45.161	WBGene00014228	mett-10	75	38.275	Caenorhabditis_elegans
ENSG00000127804	METTL16	98	95.122	ENSCJAG00000012375	METTL16	99	91.993	Callithrix_jacchus
ENSG00000127804	METTL16	99	92.857	ENSCAFG00000019296	METTL16	99	92.857	Canis_familiaris
ENSG00000127804	METTL16	99	92.857	ENSCAFG00020009699	METTL16	99	92.857	Canis_lupus_dingo
ENSG00000127804	METTL16	98	93.902	ENSCHIG00000010681	-	99	91.071	Capra_hircus
ENSG00000127804	METTL16	98	95.732	ENSTSYG00000006264	METTL16	99	93.594	Carlito_syrichta
ENSG00000127804	METTL16	98	87.805	ENSCAPG00000016057	METTL16	99	80.893	Cavia_aperea
ENSG00000127804	METTL16	98	93.293	ENSCPOG00000014842	METTL16	99	90.714	Cavia_porcellus
ENSG00000127804	METTL16	98	95.122	ENSCCAG00000028140	METTL16	99	94.107	Cebus_capucinus
ENSG00000127804	METTL16	100	96.975	ENSCATG00000034831	METTL16	100	96.975	Cercocebus_atys
ENSG00000127804	METTL16	98	93.902	ENSCLAG00000008271	METTL16	99	92.679	Chinchilla_lanigera
ENSG00000127804	METTL16	100	97.153	ENSCSAG00000013766	METTL16	100	97.153	Chlorocebus_sabaeus
ENSG00000127804	METTL16	98	86.585	ENSCPBG00000001812	METTL16	99	78.075	Chrysemys_picta_bellii
ENSG00000127804	METTL16	92	96.724	ENSCANG00000035617	METTL16	100	96.724	Colobus_angolensis_palliatus
ENSG00000127804	METTL16	98	93.902	ENSCGRG00001008131	Mettl16	99	87.857	Cricetulus_griseus_chok1gshd
ENSG00000127804	METTL16	98	93.902	ENSCGRG00000008350	Mettl16	99	87.857	Cricetulus_griseus_crigri
ENSG00000127804	METTL16	98	79.268	ENSCVAG00000013319	mettl16	99	65.536	Cyprinodon_variegatus
ENSG00000127804	METTL16	98	93.902	ENSDORG00000026252	-	86	98.462	Dipodomys_ordii
ENSG00000127804	METTL16	90	46.358	FBgn0033994	CG7544	94	43.986	Drosophila_melanogaster
ENSG00000127804	METTL16	92	80.154	ENSETEG00000010666	METTL16	99	80.154	Echinops_telfairi
ENSG00000127804	METTL16	98	93.902	ENSEASG00005009160	METTL16	99	92.321	Equus_asinus_asinus
ENSG00000127804	METTL16	98	93.902	ENSECAG00000013437	METTL16	99	92.143	Equus_caballus
ENSG00000127804	METTL16	98	93.293	ENSEEUG00000012236	METTL16	99	80.961	Erinaceus_europaeus
ENSG00000127804	METTL16	98	94.512	ENSFCAG00000006316	METTL16	99	92.513	Felis_catus
ENSG00000127804	METTL16	98	87.195	ENSFALG00000005249	METTL16	99	76.157	Ficedula_albicollis
ENSG00000127804	METTL16	98	93.902	ENSFDAG00000019991	METTL16	99	91.429	Fukomys_damarensis
ENSG00000127804	METTL16	100	99.288	ENSGGOG00000009735	METTL16	100	99.288	Gorilla_gorilla
ENSG00000127804	METTL16	98	78.049	ENSHBUG00000016510	mettl16	99	64.860	Haplochromis_burtoni
ENSG00000127804	METTL16	98	93.902	ENSHGLG00000016522	METTL16	99	91.786	Heterocephalus_glaber_female
ENSG00000127804	METTL16	98	93.902	ENSHGLG00100016354	METTL16	99	91.786	Heterocephalus_glaber_male
ENSG00000127804	METTL16	98	92.073	ENSSTOG00000011876	METTL16	99	89.107	Ictidomys_tridecemlineatus
ENSG00000127804	METTL16	99	73.214	ENSJJAG00000010440	-	99	73.214	Jaculus_jaculus
ENSG00000127804	METTL16	98	78.659	ENSKMAG00000015799	mettl16	99	65.035	Kryptolebias_marmoratus
ENSG00000127804	METTL16	99	97.500	ENSMFAG00000038724	METTL16	99	97.500	Macaca_fascicularis
ENSG00000127804	METTL16	98	95.732	ENSMMUG00000022007	METTL16	99	89.286	Macaca_mulatta
ENSG00000127804	METTL16	98	95.732	ENSMNEG00000033873	METTL16	97	100.000	Macaca_nemestrina
ENSG00000127804	METTL16	99	97.321	ENSMLEG00000034134	METTL16	99	97.321	Mandrillus_leucophaeus
ENSG00000127804	METTL16	98	78.049	ENSMZEG00005015206	mettl16	99	64.510	Maylandia_zebra
ENSG00000127804	METTL16	92	86.434	ENSMAUG00000014992	Mettl16	99	85.009	Mesocricetus_auratus
ENSG00000127804	METTL16	100	94.662	ENSMICG00000013015	METTL16	99	94.662	Microcebus_murinus
ENSG00000127804	METTL16	98	90.244	ENSMODG00000010765	METTL16	99	81.996	Monodelphis_domestica
ENSG00000127804	METTL16	98	75.610	ENSMALG00000003921	mettl16	96	77.945	Monopterus_albus
ENSG00000127804	METTL16	98	94.512	MGP_CAROLIEiJ_G0016724	Mettl16	91	98.462	Mus_caroli
ENSG00000127804	METTL16	98	94.512	ENSMUSG00000010554	Mettl16	91	98.462	Mus_musculus
ENSG00000127804	METTL16	98	93.902	MGP_PahariEiJ_G0017861	Mettl16	91	97.949	Mus_pahari
ENSG00000127804	METTL16	98	94.512	MGP_SPRETEiJ_G0017567	Mettl16	91	98.462	Mus_spretus
ENSG00000127804	METTL16	98	93.902	ENSMPUG00000012861	METTL16	99	92.692	Mustela_putorius_furo
ENSG00000127804	METTL16	98	94.512	ENSNGAG00000013830	-	92	98.462	Nannospalax_galili
ENSG00000127804	METTL16	98	78.049	ENSNBRG00000008697	mettl16	99	78.717	Neolamprologus_brichardi
ENSG00000127804	METTL16	99	98.214	ENSNLEG00000017211	METTL16	99	98.214	Nomascus_leucogenys
ENSG00000127804	METTL16	98	89.634	ENSMEUG00000015893	METTL16	99	82.238	Notamacropus_eugenii
ENSG00000127804	METTL16	98	93.902	ENSOPRG00000002177	METTL16	93	90.966	Ochotona_princeps
ENSG00000127804	METTL16	98	93.293	ENSODEG00000010129	-	85	95.146	Octodon_degus
ENSG00000127804	METTL16	75	95.736	ENSODEG00000004655	-	91	95.736	Octodon_degus
ENSG00000127804	METTL16	98	93.902	ENSODEG00000007580	-	99	91.607	Octodon_degus
ENSG00000127804	METTL16	98	78.049	ENSONIG00000008135	mettl16	99	65.035	Oreochromis_niloticus
ENSG00000127804	METTL16	98	90.244	ENSOANG00000008629	METTL16	99	79.218	Ornithorhynchus_anatinus
ENSG00000127804	METTL16	98	94.512	ENSOCUG00000016112	METTL16	99	90.731	Oryctolagus_cuniculus
ENSG00000127804	METTL16	98	95.122	ENSOGAG00000004504	METTL16	99	93.750	Otolemur_garnettii
ENSG00000127804	METTL16	98	93.902	ENSOARG00000015825	-	99	92.143	Ovis_aries
ENSG00000127804	METTL16	100	99.644	ENSPPAG00000029944	METTL16	100	99.644	Pan_paniscus
ENSG00000127804	METTL16	98	94.512	ENSPPRG00000022476	METTL16	99	92.513	Panthera_pardus
ENSG00000127804	METTL16	98	94.512	ENSPTIG00000013543	METTL16	99	92.513	Panthera_tigris_altaica
ENSG00000127804	METTL16	100	99.822	ENSPTRG00000008550	METTL16	100	99.822	Pan_troglodytes
ENSG00000127804	METTL16	98	95.732	ENSPANG00000024467	METTL16	99	94.326	Papio_anubis
ENSG00000127804	METTL16	92	77.992	ENSPSIG00000014760	METTL16	99	77.992	Pelodiscus_sinensis
ENSG00000127804	METTL16	98	95.122	ENSPEMG00000020853	-	94	98.974	Peromyscus_maniculatus_bairdii
ENSG00000127804	METTL16	82	68.571	ENSPMAG00000007254	mettl16	99	74.439	Petromyzon_marinus
ENSG00000127804	METTL16	98	90.244	ENSPCIG00000015863	METTL16	99	81.818	Phascolarctos_cinereus
ENSG00000127804	METTL16	98	78.049	ENSPREG00000022027	mettl16	99	64.903	Poecilia_reticulata
ENSG00000127804	METTL16	100	98.577	ENSPPYG00000007795	METTL16	100	98.577	Pongo_abelii
ENSG00000127804	METTL16	100	95.196	ENSPCOG00000027687	METTL16	99	95.196	Propithecus_coquereli
ENSG00000127804	METTL16	98	91.463	ENSPVAG00000002169	METTL16	67	97.297	Pteropus_vampyrus
ENSG00000127804	METTL16	92	63.774	ENSPNYG00000016660	mettl16	97	63.774	Pundamilia_nyererei
ENSG00000127804	METTL16	98	94.512	ENSRNOG00000002764	Mettl16	99	87.857	Rattus_norvegicus
ENSG00000127804	METTL16	99	96.429	ENSRBIG00000003299	METTL16	99	96.429	Rhinopithecus_bieti
ENSG00000127804	METTL16	99	96.607	ENSRROG00000037400	METTL16	99	96.607	Rhinopithecus_roxellana
ENSG00000127804	METTL16	92	93.256	ENSSBOG00000023013	METTL16	99	93.256	Saimiri_boliviensis_boliviensis
ENSG00000127804	METTL16	98	89.634	ENSSHAG00000012078	METTL16	99	82.175	Sarcophilus_harrisii
ENSG00000127804	METTL16	98	94.512	ENSSSCG00000017832	METTL16	99	91.786	Sus_scrofa
ENSG00000127804	METTL16	98	78.049	ENSTNIG00000017967	mettl16	99	64.286	Tetraodon_nigroviridis
ENSG00000127804	METTL16	98	94.512	ENSTTRG00000001187	METTL16	82	100.000	Tursiops_truncatus
ENSG00000127804	METTL16	99	92.857	ENSUMAG00000009246	METTL16	99	92.857	Ursus_maritimus
ENSG00000127804	METTL16	98	95.122	ENSVPAG00000000230	METTL16	99	92.349	Vicugna_pacos
ENSG00000127804	METTL16	99	92.679	ENSVVUG00000021891	METTL16	99	92.679	Vulpes_vulpes

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001734	mRNA (N6-adenosine)-methyltransferase activity	28525753.30197297.30197299.	IDA	Function
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003723	RNA binding	27872311.	IDA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	27872311.	IDA	Component
GO:0006402	mRNA catabolic process	-	ISS	Process
GO:0006556	S-adenosylmethionine biosynthetic process	28525753.30197297.	IDA	Process
GO:0006556	S-adenosylmethionine biosynthetic process	30197299.	IMP	Process
GO:0010608	posttranscriptional regulation of gene expression	28525753.	IDA	Process
GO:0030629	U6 snRNA 3'-end binding	28525753.29051200.	IDA	Function
GO:0035613	RNA stem-loop binding	28525753.	IDA	Function
GO:0048024	regulation of mRNA splicing, via spliceosome	28525753.	IDA	Process
GO:0052907	23S rRNA (adenine(1618)-N(6))-methyltransferase activity	21873635.	IBA	Function
GO:0061157	mRNA destabilization	-	ISS	Process
GO:0070475	rRNA base methylation	21873635.	IBA	Process
GO:0080009	mRNA methylation	30197297.30197299.	IDA	Process
GO:0120048	U6 snRNA (adenine-(43)-N(6))-methyltransferase activity	28525753.29051200.	IDA	Function
GO:0120049	snRNA (adenine-N6)-methylation	28525753.29051200.	IDA	Process