EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000128245 (Gene tree)
Gene ID: 7533
Gene Symbol: YWHAH
Alias: YWHA1
Full Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 13,143 bases
Position: chr22:31,944,461-31,957,603
Accession: 12853
RBP type: non-canonical RBP
Summary: This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence in its 5' UTR, and changes in the number of this repeat have been associated with early-onset schizophrenia and psychotic bipolar disorder. [provided by RefSeq, Jun 2009]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000479649	YWHAH-206	662	-	-	- (aa)	-	-
ENST00000443669	YWHAH-204	822	-	ENSP00000408468	39 (aa)	-	F8WEB6
ENST00000397492	YWHAH-202	1879	-	ENSP00000380629	72 (aa)	-	A2IDB1
ENST00000248975	YWHAH-201	1825	-	ENSP00000248975	246 (aa)	-	Q04917
ENST00000471374	YWHAH-205	1735	-	-	- (aa)	-	-
ENST00000420430	YWHAH-203	502	-	ENSP00000406747	162 (aa)	-	A2IDB2

Gene Model

Click here to download ENSG00000128245's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04110	Cell cycle	KEGG
hsa04114	Oocyte meiosis	KEGG
hsa04151	PI3K-Akt signaling pathway	KEGG
hsa04390	Hippo signaling pathway	KEGG
hsa05160	Hepatitis C	KEGG
hsa05203	Viral carcinogenesis	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000128245	Platelet Function Tests	3.2992100E-005	-
ENSG00000128245	Bronchodilator Agents	5E-6	26634245
ENSG00000128245	Forced Expiratory Volume	5E-6	26634245

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000128245	rs149411586	22	31955305	A	Post bronchodilator FEV1	26634245	NR unit decrease	0.25	EFO_0004314\|GO_0097366

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000128245's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000128245	YWHAH	100	86.992	ENSG00000170027	YWHAG	99	86.992	Homo_sapiens
ENSG00000128245	YWHAH	99	63.265	ENSG00000108953	YWHAE	100	69.565	Homo_sapiens
ENSG00000128245	YWHAH	100	99.187	ENSMUSG00000018965	Ywhah	100	99.187	Mus_musculus
ENSG00000128245	YWHAH	100	86.992	ENSMUSG00000051391	Ywhag	99	86.992	Mus_musculus
ENSG00000128245	YWHAH	99	63.265	ENSMUSG00000020849	Ywhae	94	63.265	Mus_musculus
ENSG00000128245	YWHAH	95	63.675	YDR099W	BMH2	85	63.675	Saccharomyces_cerevisiae
ENSG00000128245	YWHAH	98	62.140	YER177W	BMH1	87	63.675	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0002028	regulation of sodium ion transport	16728661.	IDA	Process
GO:0003779	actin binding	-	IEA	Function
GO:0005159	insulin-like growth factor receptor binding	-	ISS	Function
GO:0005515	protein binding	10713667.11697890.12524439.14676191.16545136.16672277.16775625.16959763.17979178.18045992.18242179.18397886.18458160.19172738.19553522.19615732.19640509.19860830.20642453.23075850.23572552.23622247.23752268.24895406.25852190.26496610.	IPI	Function
GO:0005737	cytoplasm	-	ISS	Component
GO:0005739	mitochondrion	-	IEA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005886	plasma membrane	16728661.	IDA	Component
GO:0006713	glucocorticoid catabolic process	15790729.	IDA	Process
GO:0006886	intracellular protein transport	-	ISS	Process
GO:0014704	intercalated disc	16728661.	IC	Component
GO:0017080	sodium channel regulator activity	16728661.	IDA	Function
GO:0019899	enzyme binding	17255105.	IPI	Function
GO:0019904	protein domain specific binding	-	ISS	Function
GO:0021762	substantia nigra development	22926577.	HEP	Process
GO:0035259	glucocorticoid receptor binding	9079630.	IPI	Function
GO:0042802	identical protein binding	17085597.17979178.	IPI	Function
GO:0042921	glucocorticoid receptor signaling pathway	15790729.	IDA	Process
GO:0044325	ion channel binding	11953308.16728661.	IPI	Function
GO:0045664	regulation of neuron differentiation	-	ISS	Process
GO:0045893	positive regulation of transcription, DNA-templated	15790729.	IDA	Process
GO:0046982	protein heterodimerization activity	11953308.	IPI	Function
GO:0048167	regulation of synaptic plasticity	-	ISS	Process
GO:0050774	negative regulation of dendrite morphogenesis	-	ISS	Process
GO:0061024	membrane organization	-	TAS	Process
GO:0070062	extracellular exosome	19056867.19199708.20458337.	HDA	Component
GO:0086010	membrane depolarization during action potential	16728661.	IDA	Process
GO:0098793	presynapse	-	IEA	Component
GO:0098978	glutamatergic synapse	-	IEA	Component
GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway	-	TAS	Process
GO:2000649	regulation of sodium ion transmembrane transporter activity	16728661.	IDA	Process