EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000128626 (Gene tree)
Gene ID: 6183
Gene Symbol: MRPS12
Alias: RPS12|RPSM12|RPMS12
Full Name: mitochondrial ribosomal protein S12
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 2,615 bases
Position: chr19:38,930,548-38,933,162
Accession: 10380
RBP type: canonical RBP
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S12P family. The encoded protein is a key component of the ribosomal small subunit and controls the decoding fidelity and susceptibility to aminoglycoside antibiotics. The gene for mitochondrial seryl-tRNA synthetase is located upstream and adjacent to this gene, and both genes are possible candidates for the autosomal dominant deafness gene (DFNA4). Splice variants that differ in the 5' UTR have been found for this gene; all three variants encode the same protein. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000308845	Ribosom_S12_S23	PF00164.25	8.5e-25	1	1
ENSP00000384579	Ribosom_S12_S23	PF00164.25	8.5e-25	1	1
ENSP00000384952	Ribosom_S12_S23	PF00164.25	8.5e-25	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
19109964	RNA editing and mitochondrial activity in promastigotes and amastigotes of Leishmania donovani.	Int J Parasitol	2009 May	Nebohacova M	doi: 10.1016/j.ijpara.2008.10.015

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000407800	MRPS12-203	1220	-	ENSP00000384952	138 (aa)	-	O15235
ENST00000308018	MRPS12-201	1207	-	ENSP00000308845	138 (aa)	-	O15235
ENST00000402029	MRPS12-202	929	-	ENSP00000384579	138 (aa)	-	O15235
ENST00000598734	MRPS12-204	641	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000128626's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03010	Ribosome	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000128626's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000128626	MRPS12	58	39.773	ENSG00000186468	RPS23	66	38.202

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000128626	MRPS12	80	76.364	ENSAPOG00000005047	si:dkey-17e16.10	77	76.364	Acanthochromis_polyacanthus
ENSG00000128626	MRPS12	100	82.609	ENSAMEG00000008722	MRPS12	99	82.609	Ailuropoda_melanoleuca
ENSG00000128626	MRPS12	80	78.182	ENSACIG00000016095	si:dkey-17e16.10	77	78.182	Amphilophus_citrinellus
ENSG00000128626	MRPS12	80	76.364	ENSAOCG00000018530	si:dkey-17e16.10	77	76.364	Amphiprion_ocellaris
ENSG00000128626	MRPS12	80	76.364	ENSAPEG00000019785	si:dkey-17e16.10	77	76.364	Amphiprion_percula
ENSG00000128626	MRPS12	80	79.091	ENSATEG00000018924	si:dkey-17e16.10	77	79.091	Anabas_testudineus
ENSG00000128626	MRPS12	88	72.951	ENSAPLG00000011925	-	88	72.951	Anas_platyrhynchos
ENSG00000128626	MRPS12	100	57.143	ENSAPLG00000014350	-	100	57.143	Anas_platyrhynchos
ENSG00000128626	MRPS12	83	80.870	ENSACAG00000003829	MRPS12	80	80.870	Anolis_carolinensis
ENSG00000128626	MRPS12	100	95.652	ENSANAG00000033654	MRPS12	99	95.652	Aotus_nancymaae
ENSG00000128626	MRPS12	80	78.182	ENSACLG00000013979	si:dkey-17e16.10	73	78.182	Astatotilapia_calliptera
ENSG00000128626	MRPS12	80	70.909	ENSAMXG00000025945	si:dkey-17e16.10	91	60.741	Astyanax_mexicanus
ENSG00000128626	MRPS12	100	83.333	ENSBTAG00000001782	MRPS12	99	83.333	Bos_taurus
ENSG00000128626	MRPS12	70	56.566	WBGene00011391	mrps-12	63	56.566	Caenorhabditis_elegans
ENSG00000128626	MRPS12	100	94.928	ENSCJAG00000043176	MRPS12	99	94.928	Callithrix_jacchus
ENSG00000128626	MRPS12	100	82.609	ENSCAFG00000005623	MRPS12	99	82.609	Canis_familiaris
ENSG00000128626	MRPS12	100	82.609	ENSCAFG00020016784	MRPS12	99	82.609	Canis_lupus_dingo
ENSG00000128626	MRPS12	100	82.609	ENSCHIG00000013852	MRPS12	99	82.609	Capra_hircus
ENSG00000128626	MRPS12	100	89.855	ENSTSYG00000009568	MRPS12	100	89.855	Carlito_syrichta
ENSG00000128626	MRPS12	100	82.979	ENSCAPG00000009543	MRPS12	99	82.979	Cavia_aperea
ENSG00000128626	MRPS12	100	89.130	ENSCPOG00000035217	MRPS12	99	89.130	Cavia_porcellus
ENSG00000128626	MRPS12	100	95.652	ENSCCAG00000035388	MRPS12	100	95.652	Cebus_capucinus
ENSG00000128626	MRPS12	100	95.652	ENSCATG00000038438	MRPS12	99	95.652	Cercocebus_atys
ENSG00000128626	MRPS12	100	88.406	ENSCLAG00000013286	MRPS12	99	88.406	Chinchilla_lanigera
ENSG00000128626	MRPS12	100	95.652	ENSCSAG00000003929	MRPS12	99	95.652	Chlorocebus_sabaeus
ENSG00000128626	MRPS12	100	63.043	ENSCHOG00000008451	MRPS12	99	63.043	Choloepus_hoffmanni
ENSG00000128626	MRPS12	81	80.357	ENSCPBG00000018941	MRPS12	72	80.357	Chrysemys_picta_bellii
ENSG00000128626	MRPS12	62	62.791	ENSCING00000014236	-	51	57.895	Ciona_intestinalis
ENSG00000128626	MRPS12	92	48.092	ENSCSAVG00000008777	-	69	48.092	Ciona_savignyi
ENSG00000128626	MRPS12	100	96.377	ENSCANG00000003652	MRPS12	99	96.377	Colobus_angolensis_palliatus
ENSG00000128626	MRPS12	100	85.507	ENSCGRG00001018968	Mrps12	99	85.507	Cricetulus_griseus_chok1gshd
ENSG00000128626	MRPS12	100	85.507	ENSCGRG00000007113	Mrps12	99	85.507	Cricetulus_griseus_crigri
ENSG00000128626	MRPS12	80	79.091	ENSCSEG00000001174	si:dkey-17e16.10	77	79.091	Cynoglossus_semilaevis
ENSG00000128626	MRPS12	80	79.091	ENSCVAG00000003253	si:dkey-17e16.10	77	79.091	Cyprinodon_variegatus
ENSG00000128626	MRPS12	83	69.748	ENSDARG00000089836	MRPS12	83	69.748	Danio_rerio
ENSG00000128626	MRPS12	100	81.159	ENSDNOG00000003918	MRPS12	99	81.159	Dasypus_novemcinctus
ENSG00000128626	MRPS12	100	86.957	ENSDORG00000001544	Mrps12	99	86.957	Dipodomys_ordii
ENSG00000128626	MRPS12	96	57.778	FBgn0003714	tko	81	63.478	Drosophila_melanogaster
ENSG00000128626	MRPS12	100	86.957	ENSETEG00000017985	MRPS12	99	86.957	Echinops_telfairi
ENSG00000128626	MRPS12	79	83.486	ENSEBUG00000003529	si:dkey-17e16.10	62	83.486	Eptatretus_burgeri
ENSG00000128626	MRPS12	100	86.232	ENSEASG00005019736	MRPS12	99	86.232	Equus_asinus_asinus
ENSG00000128626	MRPS12	100	86.232	ENSECAG00000013794	MRPS12	99	86.232	Equus_caballus
ENSG00000128626	MRPS12	67	76.842	ENSEEUG00000013868	MRPS12	100	76.842	Erinaceus_europaeus
ENSG00000128626	MRPS12	80	78.182	ENSELUG00000014973	si:dkey-17e16.10	76	78.182	Esox_lucius
ENSG00000128626	MRPS12	100	85.507	ENSFCAG00000014573	MRPS12	99	85.507	Felis_catus
ENSG00000128626	MRPS12	78	78.704	ENSFALG00000015276	MRPS12	94	78.704	Ficedula_albicollis
ENSG00000128626	MRPS12	100	86.957	ENSFDAG00000008482	MRPS12	99	86.957	Fukomys_damarensis
ENSG00000128626	MRPS12	80	79.091	ENSFHEG00000004575	si:dkey-17e16.10	77	79.091	Fundulus_heteroclitus
ENSG00000128626	MRPS12	80	78.182	ENSGMOG00000020611	si:dkey-17e16.10	99	78.182	Gadus_morhua
ENSG00000128626	MRPS12	81	80.357	ENSGALG00000038667	MRPS12	83	80.357	Gallus_gallus
ENSG00000128626	MRPS12	80	80.000	ENSGAFG00000007521	si:dkey-17e16.10	77	80.000	Gambusia_affinis
ENSG00000128626	MRPS12	80	78.182	ENSGACG00000003011	si:dkey-17e16.10	98	78.899	Gasterosteus_aculeatus
ENSG00000128626	MRPS12	100	67.105	ENSGAGG00000009748	MRPS12	97	67.105	Gopherus_agassizii
ENSG00000128626	MRPS12	100	99.275	ENSGGOG00000002500	MRPS12	100	99.275	Gorilla_gorilla
ENSG00000128626	MRPS12	80	78.182	ENSHBUG00000014480	si:dkey-17e16.10	77	78.182	Haplochromis_burtoni
ENSG00000128626	MRPS12	100	88.406	ENSHGLG00000014942	MRPS12	99	88.406	Heterocephalus_glaber_female
ENSG00000128626	MRPS12	100	88.406	ENSHGLG00100017710	MRPS12	99	88.406	Heterocephalus_glaber_male
ENSG00000128626	MRPS12	82	74.336	ENSHCOG00000010444	si:dkey-17e16.10	75	74.336	Hippocampus_comes
ENSG00000128626	MRPS12	81	79.464	ENSIPUG00000024651	MRPS12	78	79.464	Ictalurus_punctatus
ENSG00000128626	MRPS12	100	86.957	ENSSTOG00000009006	MRPS12	99	86.957	Ictidomys_tridecemlineatus
ENSG00000128626	MRPS12	100	84.783	ENSJJAG00000017837	Mrps12	99	84.783	Jaculus_jaculus
ENSG00000128626	MRPS12	80	75.455	ENSKMAG00000007949	si:dkey-17e16.10	70	75.455	Kryptolebias_marmoratus
ENSG00000128626	MRPS12	93	70.992	ENSLBEG00000001112	si:dkey-17e16.10	94	70.992	Labrus_bergylta
ENSG00000128626	MRPS12	81	81.250	ENSLACG00000018393	MRPS12	70	81.250	Latimeria_chalumnae
ENSG00000128626	MRPS12	79	81.651	ENSLOCG00000000535	si:dkey-17e16.10	75	81.651	Lepisosteus_oculatus
ENSG00000128626	MRPS12	99	88.971	ENSLAFG00000022140	MRPS12	98	88.971	Loxodonta_africana
ENSG00000128626	MRPS12	100	95.652	ENSMFAG00000044563	MRPS12	99	95.652	Macaca_fascicularis
ENSG00000128626	MRPS12	100	96.377	ENSMNEG00000040379	MRPS12	99	96.377	Macaca_nemestrina
ENSG00000128626	MRPS12	100	95.652	ENSMLEG00000036963	MRPS12	99	95.652	Mandrillus_leucophaeus
ENSG00000128626	MRPS12	80	77.273	ENSMAMG00000017962	si:dkey-17e16.10	79	77.273	Mastacembelus_armatus
ENSG00000128626	MRPS12	80	78.182	ENSMZEG00005017336	si:dkey-17e16.10	77	78.182	Maylandia_zebra
ENSG00000128626	MRPS12	99	68.085	ENSMGAG00000005414	MRPS12	99	68.085	Meleagris_gallopavo
ENSG00000128626	MRPS12	75	84.466	ENSMAUG00000019146	Mrps12	100	84.466	Mesocricetus_auratus
ENSG00000128626	MRPS12	100	86.232	ENSMICG00000045111	MRPS12	99	86.232	Microcebus_murinus
ENSG00000128626	MRPS12	100	85.507	ENSMOCG00000012666	Mrps12	100	85.507	Microtus_ochrogaster
ENSG00000128626	MRPS12	84	76.923	ENSMMOG00000010803	si:dkey-17e16.10	81	76.923	Mola_mola
ENSG00000128626	MRPS12	100	66.434	ENSMODG00000013431	MRPS12	99	66.434	Monodelphis_domestica
ENSG00000128626	MRPS12	80	77.273	ENSMALG00000004190	si:dkey-17e16.10	77	77.273	Monopterus_albus
ENSG00000128626	MRPS12	100	85.507	MGP_CAROLIEiJ_G0029457	Mrps12	99	85.507	Mus_caroli
ENSG00000128626	MRPS12	100	85.507	ENSMUSG00000045948	Mrps12	99	85.507	Mus_musculus
ENSG00000128626	MRPS12	100	84.058	MGP_PahariEiJ_G0012691	Mrps12	99	84.058	Mus_pahari
ENSG00000128626	MRPS12	100	85.507	MGP_SPRETEiJ_G0030553	Mrps12	99	85.507	Mus_spretus
ENSG00000128626	MRPS12	100	82.609	ENSMPUG00000017750	MRPS12	99	82.609	Mustela_putorius_furo
ENSG00000128626	MRPS12	100	86.232	ENSMLUG00000006076	MRPS12	99	86.232	Myotis_lucifugus
ENSG00000128626	MRPS12	87	87.500	ENSNGAG00000022099	Mrps12	99	82.609	Nannospalax_galili
ENSG00000128626	MRPS12	80	78.182	ENSNBRG00000007244	si:dkey-17e16.10	77	78.182	Neolamprologus_brichardi
ENSG00000128626	MRPS12	80	76.577	ENSMEUG00000005688	MRPS12	99	76.577	Notamacropus_eugenii
ENSG00000128626	MRPS12	100	87.681	ENSODEG00000016161	MRPS12	99	87.681	Octodon_degus
ENSG00000128626	MRPS12	86	74.790	ENSONIG00000002022	si:dkey-17e16.10	80	74.790	Oreochromis_niloticus
ENSG00000128626	MRPS12	100	84.058	ENSOCUG00000000689	MRPS12	100	84.058	Oryctolagus_cuniculus
ENSG00000128626	MRPS12	80	79.091	ENSORLG00000007040	si:dkey-17e16.10	79	79.091	Oryzias_latipes
ENSG00000128626	MRPS12	80	79.091	ENSORLG00020011268	MRPS12	79	79.091	Oryzias_latipes_hni
ENSG00000128626	MRPS12	80	79.091	ENSORLG00015009378	MRPS12	79	79.091	Oryzias_latipes_hsok
ENSG00000128626	MRPS12	80	79.091	ENSOMEG00000001427	si:dkey-17e16.10	79	79.091	Oryzias_melastigma
ENSG00000128626	MRPS12	100	85.507	ENSOGAG00000008295	-	99	85.507	Otolemur_garnettii
ENSG00000128626	MRPS12	100	77.536	ENSOGAG00000025634	-	99	77.536	Otolemur_garnettii
ENSG00000128626	MRPS12	100	82.609	ENSOARG00000005927	MRPS12	99	82.609	Ovis_aries
ENSG00000128626	MRPS12	100	99.275	ENSPPAG00000041637	MRPS12	100	99.275	Pan_paniscus
ENSG00000128626	MRPS12	100	84.783	ENSPPRG00000011742	MRPS12	99	84.783	Panthera_pardus
ENSG00000128626	MRPS12	100	71.739	ENSPTIG00000008427	MRPS12	99	75.362	Panthera_tigris_altaica
ENSG00000128626	MRPS12	100	99.275	ENSPTRG00000010948	MRPS12	100	99.275	Pan_troglodytes
ENSG00000128626	MRPS12	100	95.652	ENSPANG00000021673	MRPS12	99	95.652	Papio_anubis
ENSG00000128626	MRPS12	80	77.273	ENSPKIG00000006716	si:dkey-17e16.10	77	77.273	Paramormyrops_kingsleyae
ENSG00000128626	MRPS12	100	68.421	ENSPSIG00000014383	MRPS12	99	68.421	Pelodiscus_sinensis
ENSG00000128626	MRPS12	87	75.833	ENSPMGG00000009631	si:dkey-17e16.10	85	75.833	Periophthalmus_magnuspinnatus
ENSG00000128626	MRPS12	100	84.783	ENSPEMG00000016700	Mrps12	99	84.783	Peromyscus_maniculatus_bairdii
ENSG00000128626	MRPS12	91	68.504	ENSPMAG00000008051	si:dkey-17e16.10	79	68.504	Petromyzon_marinus
ENSG00000128626	MRPS12	100	71.429	ENSPCIG00000010531	-	99	71.429	Phascolarctos_cinereus
ENSG00000128626	MRPS12	96	67.669	ENSPFOG00000018863	si:dkey-17e16.10	90	67.669	Poecilia_formosa
ENSG00000128626	MRPS12	96	67.669	ENSPLAG00000008933	si:dkey-17e16.10	90	67.669	Poecilia_latipinna
ENSG00000128626	MRPS12	80	77.273	ENSPMEG00000005155	si:dkey-17e16.10	73	77.273	Poecilia_mexicana
ENSG00000128626	MRPS12	96	68.421	ENSPREG00000014123	si:dkey-17e16.10	86	68.421	Poecilia_reticulata
ENSG00000128626	MRPS12	100	97.826	ENSPPYG00000009950	MRPS12	100	97.826	Pongo_abelii
ENSG00000128626	MRPS12	99	88.235	ENSPCAG00000010853	MRPS12	99	88.235	Procavia_capensis
ENSG00000128626	MRPS12	100	86.957	ENSPCOG00000020370	MRPS12	99	86.957	Propithecus_coquereli
ENSG00000128626	MRPS12	100	84.783	ENSPVAG00000011605	MRPS12	99	84.783	Pteropus_vampyrus
ENSG00000128626	MRPS12	80	78.182	ENSPNYG00000015506	si:dkey-17e16.10	73	78.182	Pundamilia_nyererei
ENSG00000128626	MRPS12	98	69.630	ENSPNAG00000016315	si:dkey-17e16.10	90	68.116	Pygocentrus_nattereri
ENSG00000128626	MRPS12	100	86.957	ENSRNOG00000019949	Mrps12	99	86.957	Rattus_norvegicus
ENSG00000128626	MRPS12	100	96.377	ENSRBIG00000029741	MRPS12	99	96.377	Rhinopithecus_bieti
ENSG00000128626	MRPS12	100	95.652	ENSRROG00000030787	MRPS12	99	95.652	Rhinopithecus_roxellana
ENSG00000128626	MRPS12	100	96.377	ENSSBOG00000025707	MRPS12	99	96.377	Saimiri_boliviensis_boliviensis
ENSG00000128626	MRPS12	86	71.200	ENSSFOG00015018102	mrps12	87	71.200	Scleropages_formosus
ENSG00000128626	MRPS12	98	66.912	ENSSMAG00000004249	si:dkey-17e16.10	91	66.912	Scophthalmus_maximus
ENSG00000128626	MRPS12	80	76.364	ENSSDUG00000020424	si:dkey-17e16.10	76	76.364	Seriola_dumerili
ENSG00000128626	MRPS12	80	76.364	ENSSLDG00000016320	si:dkey-17e16.10	76	76.364	Seriola_lalandi_dorsalis
ENSG00000128626	MRPS12	100	78.986	ENSSARG00000006985	MRPS12	99	78.986	Sorex_araneus
ENSG00000128626	MRPS12	81	82.143	ENSSPUG00000004675	MRPS12	73	82.143	Sphenodon_punctatus
ENSG00000128626	MRPS12	80	74.545	ENSSPAG00000012951	si:dkey-17e16.10	77	74.545	Stegastes_partitus
ENSG00000128626	MRPS12	100	87.681	ENSSSCG00000031860	MRPS12	99	87.681	Sus_scrofa
ENSG00000128626	MRPS12	79	77.982	ENSTGUG00000016491	MRPS12	99	77.982	Taeniopygia_guttata
ENSG00000128626	MRPS12	80	79.091	ENSTRUG00000017342	si:dkey-17e16.10	77	79.091	Takifugu_rubripes
ENSG00000128626	MRPS12	96	69.173	ENSTNIG00000004898	si:dkey-17e16.10	96	69.173	Tetraodon_nigroviridis
ENSG00000128626	MRPS12	100	88.406	ENSTBEG00000001288	MRPS12	99	88.406	Tupaia_belangeri
ENSG00000128626	MRPS12	100	85.507	ENSTTRG00000011794	MRPS12	99	85.507	Tursiops_truncatus
ENSG00000128626	MRPS12	100	81.159	ENSUAMG00000011626	MRPS12	99	81.159	Ursus_americanus
ENSG00000128626	MRPS12	100	81.884	ENSUMAG00000019235	MRPS12	99	81.884	Ursus_maritimus
ENSG00000128626	MRPS12	100	82.609	ENSVVUG00000006433	MRPS12	70	82.609	Vulpes_vulpes
ENSG00000128626	MRPS12	80	80.909	ENSXETG00000005326	mrps12	74	80.909	Xenopus_tropicalis
ENSG00000128626	MRPS12	80	80.000	ENSXCOG00000020766	si:dkey-17e16.10	74	80.000	Xiphophorus_couchianus
ENSG00000128626	MRPS12	80	80.000	ENSXMAG00000027119	si:dkey-17e16.10	77	80.000	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0003735	structural constituent of ribosome	21873635.	IBA	Function
GO:0003735	structural constituent of ribosome	11402041.	ISS	Function
GO:0005515	protein binding	12646258.12970870.	IPI	Function
GO:0005743	mitochondrial inner membrane	-	TAS	Component
GO:0005761	mitochondrial ribosome	9545647.	TAS	Component
GO:0005763	mitochondrial small ribosomal subunit	25838379.	IDA	Component
GO:0005763	mitochondrial small ribosomal subunit	11402041.	ISS	Component
GO:0006412	translation	21873635.	IBA	Process
GO:0032543	mitochondrial translation	11402041.	ISS	Process
GO:0070125	mitochondrial translational elongation	-	TAS	Process
GO:0070126	mitochondrial translational termination	-	TAS	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
18790094	cis-acting sequences and trans-acting factors in the localization of mRNA for mitochondrial ribosomal proteins.	Biochim Biophys Acta	2008 Dec	Russo A	doi: 10.1016/j.bbagrm.2008.08.006

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr19	38931205	Intron	novel		0.1
BLCA	chr19	38931240	Intron	novel		0.16
BLCA	chr19	38932355	Silent	novel	L24L	0.13
BLCA	chr19	38931251	Intron	novel		0.21
BRCA	chr19	38932380	Missense_Mutation	novel	L33V	0.51
BRCA	chr19	38931310	Missense_Mutation	novel	L6I	0.07
BRCA	chr19	38932551	Missense_Mutation	NA	E90K	0.48	Ribosom_S12_S23
CESC	chr19	38932478	Silent	rs372051367	T65T	0.38
CESC	chr19	38931171	Intron	novel		0.1
CESC	chr19	38931203	Intron	novel		0.11
COAD	chr19	38931088	Intron	novel		0.5
COAD	chr19	38932451	Silent	rs541356492	P56P	0.29
COAD	chr19	38932450	Missense_Mutation	novel	P56L	0.4	Ribosom_S12_S23
COAD	chr19	38932549	Missense_Mutation	rs768970230	R89H	0.32	Ribosom_S12_S23
COAD	chr19	38931282	5'UTR	novel		0.45
COAD	chr19	38932623	Missense_Mutation	rs530819757	R114C	0.1	Ribosom_S12_S23
ESCA	chr19	38932350	Missense_Mutation	rs150096976	R23W	0.46
GBM	chr19	38932533	Missense_Mutation	rs140018981	R84W	0.2	Ribosom_S12_S23
GBM	chr19	38931133	Intron	novel		0.47
HNSC	chr19	38931108	Intron	novel		0.28
KICH	chr19	38932533	Frame_Shift_Ins	novel	*V92Qfs132**	0.5	Ribosom_S12_S23
KIRC	chr19	38932435	Missense_Mutation	novel	P51H	0.28	Ribosom_S12_S23
LUAD	chr19	38931232	Intron	novel		0.24
LUAD	chr19	38932422	Missense_Mutation	rs772487012	R47W	0.14
LUAD	chr19	38931247	Intron	novel		0.13
LUAD	chr19	38932662	Missense_Mutation	novel	R127C	0.08	Ribosom_S12_S23
LUSC	chr19	38932417	Missense_Mutation	rs769557703	P45L	0.28
LUSC	chr19	38932404	Frame_Shift_Del	NA	*K43Sfs16**	0.24
OV	chr19	38932803	3'UTR	novel		0.12
OV	chr19	38931233	Intron	novel		0.09
OV	chr19	38932548	Missense_Mutation	novel	R89G	0.37	Ribosom_S12_S23
PAAD	chr19	38932775	3'UTR	rs767678849		0.18
SKCM	chr19	38931264	Intron	rs745984434		0.24
SKCM	chr19	38932768	3'UTR	novel		0.21
STAD	chr19	38932601	Missense_Mutation	NA	Q106H	0.06	Ribosom_S12_S23
STAD	chr19	38932758	3'UTR	novel		0.59
STAD	chr19	38932477	Missense_Mutation	NA	T65M	0.09	Ribosom_S12_S23
UCEC	chr19	38932396	Missense_Mutation	rs201447868	R38H	0.43
UCEC	chr19	38932477	Missense_Mutation	NA	T65M	0.1	Ribosom_S12_S23
UCEC	chr19	38932400	Frame_Shift_Del	novel	*K43Sfs16**	0.44
UCEC	chr19	38932455	Silent	novel	L58L	0.16
UCEC	chr19	38932439	Silent	novel	T52T	0.15
UCEC	chr19	38931337	Missense_Mutation	novel	T15P	0.38
UCEC	chr19	38932827	3'UTR	novel		0.3
UCEC	chr19	38932726	3'UTR	rs750977311		0.56
UCEC	chr19	38932644	Missense_Mutation	rs754668341	V121I	0.33	Ribosom_S12_S23
UCEC	chr19	38930952	5'UTR	novel		0.56
UCEC	chr19	38932666	Missense_Mutation	novel	G128D	0.38	Ribosom_S12_S23
UCEC	chr19	38932694	Missense_Mutation	novel	K137N	0.26
UCEC	chr19	38932790	3'UTR	novel		0.38
UCEC	chr19	38932704	3'UTR	novel		0.38
UCEC	chr19	38932783	3'UTR	novel		0.4
UCEC	chr19	38932701	3'UTR	rs773420592		0.31

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KIRP	DEL	0.0451	0.054726
OV	AMP	0.3644	2.2539e-28
READ	DEL	0.0545	0.23023
UCS	DEL	0.125	0.12448

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00011	Kaplan-Meier Survival Analysis
MESO	0.021	Kaplan-Meier Survival Analysis
UCS	0.03	Kaplan-Meier Survival Analysis
SKCM	0.0001	Kaplan-Meier Survival Analysis
LAML	0.0014	Kaplan-Meier Survival Analysis
UCEC	0.015	Kaplan-Meier Survival Analysis
LIHC	0.013	Kaplan-Meier Survival Analysis
DLBC	0.048	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
CHOL	0.032	Kaplan-Meier Survival Analysis
LUAD	0.0021	Kaplan-Meier Survival Analysis
UVM	0.0016	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Paralogs

Orthologs

Gene Ontology

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742