EuRBPDB

Description

Ensembl ID: ENSG00000128708 (Gene tree)
Gene ID: 8520
Gene Symbol: HAT1
Alias: KAT1
Full Name: histone acetyltransferase 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 61,262 bases
Position: chr2:171,922,425-171,983,686
Accession: 4821
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is a type B histone acetyltransferase (HAT) that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are in turn imported into the nucleus for de novo deposition onto nascent DNA chains. Histone acetylation, particularly of histone H4, plays an important role in replication-dependent chromatin assembly. Specifically, this HAT can acetylate soluble but not nucleosomal histone H4 at lysines 5 and 12, and to a lesser degree, histone H2A at lysine 5. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jun 2009]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
22223882	Regulation of an RNA granule during spermatogenesis: acetylation of MVH in the chromatoid body of germ cells.	J Cell Sci	2011 Dec 15	Nagamori I	doi: 10.1242/jcs.096461
10839822	Acetylation of histones and transcription-related factors.	Microbiol Mol Biol Rev	2000 Jun	Sterner DE	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000460481	HAT1-205	600	-	-	- (aa)	-	-
ENST00000264108	HAT1-201	1626	XM_006712808	ENSP00000264108	419 (aa)	XP_006712871	O14929
ENST00000392584	HAT1-202	3609	-	-	- (aa)	-	-
ENST00000494601	HAT1-206	3845	-	-	- (aa)	-	-
ENST00000457761	HAT1-204	1642	-	ENSP00000403466	125 (aa)	-	F8W9G7
ENST00000412731	HAT1-203	1567	-	ENSP00000407921	46 (aa)	-	F8WEW1

Gene Model

Pathways

Pathway ID	Pathway Name	Source
hsa05034	Alcoholism	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000128708	Autistic Disorder	2.0146000E-005	-
ENSG00000128708	Autistic Disorder	2.4073000E-005	-
ENSG00000128708	Autistic Disorder	3.0260000E-005	-
ENSG00000128708	Myopia	3E-15	27182965

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000128708	rs72890842	2	171978369	T	Myopia (age of diagnosis)	29808027	[0.051-0.084] unit decrease	0.0673	EFO_0004847\|HP_0000545
ENSG00000128708	rs56133507	2	171961945	T	Educational attainment (MTAG)	30038396	[0.011-0.018] unit increase	0.0142	EFO_0004784
ENSG00000128708	rs2165934	2	171955818	A	Highest math class taken (MTAG)	30038396	[0.0094-0.0164] unit increase	0.0129	EFO_0004875

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000784	nuclear chromosome, telomeric region	19135898.	HDA	Component
GO:0000790	nuclear chromatin	21873635.	IBA	Component
GO:0000790	nuclear chromatin	14718166.	IDA	Component
GO:0004402	histone acetyltransferase activity	9427644.	TAS	Function
GO:0005515	protein binding	19862764.22190034.22615379.25416956.	IPI	Function
GO:0005634	nucleus	9427644.	TAS	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	-	IEA	Component
GO:0006323	DNA packaging	9427644.	TAS	Process
GO:0006335	DNA replication-dependent nucleosome assembly	14718166.	IDA	Process
GO:0006336	DNA replication-independent nucleosome assembly	14718166.	IDA	Process
GO:0006348	chromatin silencing at telomere	-	IEA	Process
GO:0006475	internal protein amino acid acetylation	9427644.	TAS	Process
GO:0007584	response to nutrient	-	IEA	Process
GO:0010485	H4 histone acetyltransferase activity	21873635.	IBA	Function
GO:0010485	H4 histone acetyltransferase activity	22615379.	IDA	Function
GO:0016363	nuclear matrix	-	IEA	Component
GO:0032991	protein-containing complex	14718166.	IDA	Component
GO:0042393	histone binding	21873635.	IBA	Function
GO:0043231	intracellular membrane-bounded organelle	-	IDA	Component
GO:0043967	histone H4 acetylation	21873635.	IBA	Process
GO:0043967	histone H4 acetylation	22615379.	IDA	Process