EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000128829 (Gene tree)
Gene ID: 440275
Gene Symbol: EIF2AK4
Alias: GCN2|KIAA1338
Full Name: eukaryotic translation initiation factor 2 alpha kinase 4
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 101,473 bases
Position: chr15:39,934,124-40,035,596
Accession: 19687
RBP type: canonical RBP
Summary: This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. The encoded protein responds to amino acid deprivation by binding uncharged transfer RNAs. It may also be activated by glucose deprivation and viral infection. Mutations in this gene have been found in individuals suffering from autosomal recessive pulmonary venoocclusive-disease-2. [provided by RefSeq, Mar 2014]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000453575	HGTP_anticodon2	PF12745.7	2e-17	1	1
ENSP00000263791	HGTP_anticodon2	PF12745.7	2.5e-17	1	1
ENSP00000453575	tRNA-synt_His	PF13393.6	3.1e-14	1	1
ENSP00000263791	tRNA-synt_His	PF13393.6	4.4e-14	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
9430731	Ribosome-binding domain of eukaryotic initiation factor-2 kinase GCN2 facilitates translation control.	J Biol Chem	1998 Jan 16	Zhu S	-
7623840	The histidyl-tRNA synthetase-related sequence in the eIF-2 alpha protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acids.	Mol Cell Biol	1995 Aug	Wek SA	-
29621237	Amino acid starvation sensing dampens IL-1β production by activating riboclustering and autophagy.	PLoS Biol	2018 Apr 5	Battu S	doi: 10.1371/journal.pbio.2005317
16601681	Antiviral effect of the mammalian translation initiation factor 2alpha kinase GCN2 against RNA viruses.	EMBO J	2006 Apr 19	Berlanga JJ	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000624709	EIF2AK4-211	1314	-	-	- (aa)	-	-
ENST00000560855	EIF2AK4-210	4789	-	ENSP00000453575	1427 (aa)	-	H0YME5
ENST00000558743	EIF2AK4-204	581	-	-	- (aa)	-	-
ENST00000263791	EIF2AK4-201	5499	XM_005254392	ENSP00000263791	1649 (aa)	XP_005254449	Q9P2K8
ENST00000558823	EIF2AK4-205	638	-	ENSP00000454210	80 (aa)	-	H0YNY9
ENST00000559032	EIF2AK4-206	1089	-	-	- (aa)	-	-
ENST00000559624	EIF2AK4-208	3548	-	ENSP00000453148	616 (aa)	-	Q9P2K8
ENST00000558629	EIF2AK4-203	4374	-	-	- (aa)	-	-
ENST00000558557	EIF2AK4-202	2449	-	-	- (aa)	-	-
ENST00000560648	EIF2AK4-209	687	-	ENSP00000453968	136 (aa)	-	H0YND8
ENST00000559311	EIF2AK4-207	535	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000128829's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04140	Autophagy - animal	KEGG
hsa04141	Protein processing in endoplasmic reticulum	KEGG
hsa05160	Hepatitis C	KEGG
hsa05162	Measles	KEGG
hsa05168	Herpes simplex virus 1 infection	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000128829	Body Mass Index	1E-6	24827717
ENSG00000128829	Endometrial Neoplasms	2E-8	27135401
ENSG00000128829	Carcinoma, Endometrioid	2E-7	27135401
ENSG00000128829	Corneal Topography	6E-6	22969067
ENSG00000128829	Haloperidol	9E-6	24751813
ENSG00000128829	Psychotic Disorders	9E-6	24751813

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000128829	rs12050884	15	40014133	A	High light scatter reticulocyte percentage of red cells	27863252	[0.018-0.036] unit increase	0.02700095	EFO_0007986
ENSG00000128829	rs28714278	15	39992007	A	Mean corpuscular hemoglobin	27863252	[0.018-0.035] unit increase	0.02657803	EFO_0004527
ENSG00000128829	rs2412459	15	40003758	C	Response to haloperidol in psychosis	24751813			EFO_0005407\|GO_1905119
ENSG00000128829	rs2250402	15	40030351	T	Corneal curvature	22969067	[0.033-0.085] mm increase	0.0592	EFO_0004345
ENSG00000128829	rs937213	15	40029923	C	Endometrial cancer	27135401	[1.08-1.16]	1.1111112	EFO_1001512
ENSG00000128829	rs937213	15	40029923	C	Endometrial endometrioid carcinoma	27135401	[1.06-1.16]	1.1111112	EFO_1001514
ENSG00000128829	rs4432245	15	40032280	C	Body mass index	24827717			EFO_0004340
ENSG00000128829	rs12050884	15	40014133	A	Reticulocyte fraction of red cells	27863252	[0.02-0.037] unit increase	0.02857949	EFO_0007986
ENSG00000128829	rs12050884	15	40014133	A	Red cell distribution width	27863252	[0.027-0.044] unit decrease	0.03570059	EFO_0005192
ENSG00000128829	rs937213	15	40029923	C	Endometrial cancer	30093612	[1.06-1.13]	1.09	EFO_1001512
ENSG00000128829	rs937213	15	40029923	C	Endometrial cancer (endometrioid histology)	30093612	[1.08-1.16]	1.12	EFO_1001512
ENSG00000128829	rs12164905	15	40008490	T	Red cell distribution width	28957414	[0.03-0.05] unit decrease	0.0398081	EFO_0005192
ENSG00000128829	rs12050884	15	40014133	?	Red cell distribution width	30595370			EFO_0005192
ENSG00000128829	rs3736290	15	40029150	?	Systolic blood pressure	30595370			EFO_0006335
ENSG00000128829	rs35602605	15	40016658	?	Mean corpuscular hemoglobin	30595370			EFO_0004527
ENSG00000128829	rs12050884	15	40014133	?	Red blood cell count	30595370			EFO_0004305
ENSG00000128829	rs3736290	15	40029150	A	Systolic blood pressure	30578418	[0.13-0.26] mmHg increase	0.1926	EFO_0006335
ENSG00000128829	rs937213	15	40029923	T	Diastolic blood pressure	27841878	unit increase	0.131	EFO_0006336
ENSG00000128829	rs937213	15	40029923	T	Systolic blood pressure	27841878	unit increase	0.256	EFO_0006335
ENSG00000128829	rs937213	15	40029923	T	Pulse pressure	27841878	unit increase	0.122	EFO_0005763
ENSG00000128829	rs937213	15	40029923	T	Systolic blood pressure	27841878	unit increase	0.267	EFO_0006335

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000128829's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000128829	EIF2AK4	94	60.014	ENSAPOG00000013188	EIF2AK4	99	58.820	Acanthochromis_polyacanthus
ENSG00000128829	EIF2AK4	97	90.924	ENSAMEG00000017234	EIF2AK4	100	88.592	Ailuropoda_melanoleuca
ENSG00000128829	EIF2AK4	96	61.434	ENSACIG00000013808	EIF2AK4	100	59.482	Amphilophus_citrinellus
ENSG00000128829	EIF2AK4	99	61.802	ENSAOCG00000001454	EIF2AK4	99	61.922	Amphiprion_ocellaris
ENSG00000128829	EIF2AK4	98	62.630	ENSAPEG00000000980	EIF2AK4	98	63.253	Amphiprion_percula
ENSG00000128829	EIF2AK4	99	58.100	ENSATEG00000003897	EIF2AK4	99	62.077	Anabas_testudineus
ENSG00000128829	EIF2AK4	99	72.858	ENSAPLG00000003298	EIF2AK4	100	73.053	Anas_platyrhynchos
ENSG00000128829	EIF2AK4	99	74.393	ENSACAG00000014521	EIF2AK4	99	74.454	Anolis_carolinensis
ENSG00000128829	EIF2AK4	100	97.635	ENSANAG00000031717	EIF2AK4	100	97.709	Aotus_nancymaae
ENSG00000128829	EIF2AK4	99	61.180	ENSACLG00000002357	EIF2AK4	100	61.832	Astatotilapia_calliptera
ENSG00000128829	EIF2AK4	78	64.865	ENSAMXG00000008532	EIF2AK4	99	59.238	Astyanax_mexicanus
ENSG00000128829	EIF2AK4	99	93.537	ENSBTAG00000014351	EIF2AK4	99	93.537	Bos_taurus
ENSG00000128829	EIF2AK4	100	97.817	ENSCJAG00000020915	EIF2AK4	100	97.817	Callithrix_jacchus
ENSG00000128829	EIF2AK4	99	90.444	ENSCAFG00000008775	EIF2AK4	99	90.444	Canis_familiaris
ENSG00000128829	EIF2AK4	99	87.278	ENSCAFG00020005966	EIF2AK4	100	90.404	Canis_lupus_dingo
ENSG00000128829	EIF2AK4	99	93.476	ENSCHIG00000006777	EIF2AK4	99	93.476	Capra_hircus
ENSG00000128829	EIF2AK4	98	94.001	ENSTSYG00000009424	EIF2AK4	99	94.187	Carlito_syrichta
ENSG00000128829	EIF2AK4	97	82.416	ENSCAPG00000000402	EIF2AK4	99	80.372	Cavia_aperea
ENSG00000128829	EIF2AK4	99	92.683	ENSCPOG00000008969	EIF2AK4	99	92.744	Cavia_porcellus
ENSG00000128829	EIF2AK4	100	97.759	ENSCCAG00000021302	EIF2AK4	100	97.759	Cebus_capucinus
ENSG00000128829	EIF2AK4	100	98.848	ENSCATG00000043911	EIF2AK4	100	98.848	Cercocebus_atys
ENSG00000128829	EIF2AK4	100	93.519	ENSCLAG00000009700	EIF2AK4	99	93.594	Chinchilla_lanigera
ENSG00000128829	EIF2AK4	100	98.727	ENSCSAG00000007330	EIF2AK4	100	98.727	Chlorocebus_sabaeus
ENSG00000128829	EIF2AK4	91	89.744	ENSCHOG00000005294	EIF2AK4	93	80.183	Choloepus_hoffmanni
ENSG00000128829	EIF2AK4	99	75.260	ENSCPBG00000024736	EIF2AK4	99	75.398	Chrysemys_picta_bellii
ENSG00000128829	EIF2AK4	80	36.931	ENSCING00000020338	-	99	37.186	Ciona_intestinalis
ENSG00000128829	EIF2AK4	99	98.353	ENSCANG00000041601	EIF2AK4	100	97.089	Colobus_angolensis_palliatus
ENSG00000128829	EIF2AK4	100	91.333	ENSCGRG00001004369	Eif2ak4	99	91.448	Cricetulus_griseus_chok1gshd
ENSG00000128829	EIF2AK4	100	91.333	ENSCGRG00000001286	Eif2ak4	99	91.448	Cricetulus_griseus_crigri
ENSG00000128829	EIF2AK4	99	61.418	ENSCSEG00000000164	EIF2AK4	99	61.802	Cynoglossus_semilaevis
ENSG00000128829	EIF2AK4	98	65.432	ENSCVAG00000019076	EIF2AK4	100	62.162	Cyprinodon_variegatus
ENSG00000128829	EIF2AK4	79	62.500	ENSDARG00000104276	EIF2AK4	94	61.491	Danio_rerio
ENSG00000128829	EIF2AK4	99	92.378	ENSDNOG00000011085	EIF2AK4	99	92.439	Dasypus_novemcinctus
ENSG00000128829	EIF2AK4	99	85.959	ENSDORG00000001179	Eif2ak4	99	87.819	Dipodomys_ordii
ENSG00000128829	EIF2AK4	94	90.670	ENSETEG00000015158	EIF2AK4	93	90.670	Echinops_telfairi
ENSG00000128829	EIF2AK4	98	44.471	ENSEBUG00000008135	EIF2AK4	95	44.592	Eptatretus_burgeri
ENSG00000128829	EIF2AK4	99	93.716	ENSEASG00005016676	EIF2AK4	99	93.716	Equus_asinus_asinus
ENSG00000128829	EIF2AK4	99	94.021	ENSECAG00000000348	EIF2AK4	99	94.021	Equus_caballus
ENSG00000128829	EIF2AK4	88	90.000	ENSEEUG00000012498	EIF2AK4	92	87.018	Erinaceus_europaeus
ENSG00000128829	EIF2AK4	96	62.229	ENSELUG00000005334	EIF2AK4	100	59.651	Esox_lucius
ENSG00000128829	EIF2AK4	99	90.354	ENSFCAG00000008980	EIF2AK4	99	90.293	Felis_catus
ENSG00000128829	EIF2AK4	99	70.600	ENSFALG00000005362	EIF2AK4	100	71.373	Ficedula_albicollis
ENSG00000128829	EIF2AK4	97	93.613	ENSFDAG00000013094	EIF2AK4	99	91.389	Fukomys_damarensis
ENSG00000128829	EIF2AK4	99	61.005	ENSFHEG00000014511	EIF2AK4	99	61.339	Fundulus_heteroclitus
ENSG00000128829	EIF2AK4	96	59.588	ENSGMOG00000011346	EIF2AK4	100	57.997	Gadus_morhua
ENSG00000128829	EIF2AK4	99	72.125	ENSGALG00000009611	EIF2AK4	99	72.529	Gallus_gallus
ENSG00000128829	EIF2AK4	93	62.922	ENSGAFG00000017420	EIF2AK4	99	62.373	Gambusia_affinis
ENSG00000128829	EIF2AK4	99	60.379	ENSGACG00000006146	EIF2AK4	99	60.739	Gasterosteus_aculeatus
ENSG00000128829	EIF2AK4	100	75.361	ENSGAGG00000010083	EIF2AK4	99	75.622	Gopherus_agassizii
ENSG00000128829	EIF2AK4	100	99.636	ENSGGOG00000000245	EIF2AK4	100	99.636	Gorilla_gorilla
ENSG00000128829	EIF2AK4	99	61.465	ENSHBUG00000016881	EIF2AK4	100	62.166	Haplochromis_burtoni
ENSG00000128829	EIF2AK4	99	92.129	ENSHGLG00000006278	EIF2AK4	99	92.268	Heterocephalus_glaber_female
ENSG00000128829	EIF2AK4	99	89.986	ENSHGLG00100006265	EIF2AK4	99	91.640	Heterocephalus_glaber_male
ENSG00000128829	EIF2AK4	99	60.731	ENSHCOG00000018707	EIF2AK4	99	61.400	Hippocampus_comes
ENSG00000128829	EIF2AK4	98	64.103	ENSIPUG00000018372	EIF2AK4	97	61.354	Ictalurus_punctatus
ENSG00000128829	EIF2AK4	99	93.468	ENSSTOG00000015609	EIF2AK4	99	93.468	Ictidomys_tridecemlineatus
ENSG00000128829	EIF2AK4	99	90.726	ENSJJAG00000024224	Eif2ak4	100	90.619	Jaculus_jaculus
ENSG00000128829	EIF2AK4	99	61.976	ENSKMAG00000000304	EIF2AK4	100	62.339	Kryptolebias_marmoratus
ENSG00000128829	EIF2AK4	99	61.151	ENSLBEG00000026463	EIF2AK4	99	61.409	Labrus_bergylta
ENSG00000128829	EIF2AK4	97	91.823	ENSLAFG00000001001	EIF2AK4	100	91.823	Loxodonta_africana
ENSG00000128829	EIF2AK4	82	98.276	ENSMFAG00000035646	EIF2AK4	97	98.276	Macaca_fascicularis
ENSG00000128829	EIF2AK4	100	98.908	ENSMMUG00000038966	EIF2AK4	100	98.908	Macaca_mulatta
ENSG00000128829	EIF2AK4	100	98.848	ENSMNEG00000022967	EIF2AK4	100	98.848	Macaca_nemestrina
ENSG00000128829	EIF2AK4	99	98.783	ENSMLEG00000038061	EIF2AK4	100	98.783	Mandrillus_leucophaeus
ENSG00000128829	EIF2AK4	99	57.160	ENSMAMG00000007442	EIF2AK4	99	58.123	Mastacembelus_armatus
ENSG00000128829	EIF2AK4	94	61.964	ENSMZEG00005027003	EIF2AK4	100	61.627	Maylandia_zebra
ENSG00000128829	EIF2AK4	99	72.036	ENSMGAG00000012034	EIF2AK4	100	72.924	Meleagris_gallopavo
ENSG00000128829	EIF2AK4	97	91.333	ENSMAUG00000005195	Eif2ak4	96	90.864	Mesocricetus_auratus
ENSG00000128829	EIF2AK4	99	94.689	ENSMICG00000007608	EIF2AK4	99	94.689	Microcebus_murinus
ENSG00000128829	EIF2AK4	99	91.387	ENSMOCG00000020630	Eif2ak4	99	91.368	Microtus_ochrogaster
ENSG00000128829	EIF2AK4	94	56.794	ENSMMOG00000001959	EIF2AK4	99	55.626	Mola_mola
ENSG00000128829	EIF2AK4	100	82.427	ENSMODG00000000619	EIF2AK4	98	83.667	Monodelphis_domestica
ENSG00000128829	EIF2AK4	77	62.963	ENSMALG00000015846	EIF2AK4	92	61.237	Monopterus_albus
ENSG00000128829	EIF2AK4	99	90.104	MGP_CAROLIEiJ_G0024115	Eif2ak4	100	90.671	Mus_caroli
ENSG00000128829	EIF2AK4	99	90.348	ENSMUSG00000005102	Eif2ak4	100	90.889	Mus_musculus
ENSG00000128829	EIF2AK4	99	89.921	MGP_PahariEiJ_G0025558	Eif2ak4	100	90.379	Mus_pahari
ENSG00000128829	EIF2AK4	99	90.287	MGP_SPRETEiJ_G0025031	Eif2ak4	100	90.743	Mus_spretus
ENSG00000128829	EIF2AK4	99	89.024	ENSMPUG00000008299	EIF2AK4	99	88.963	Mustela_putorius_furo
ENSG00000128829	EIF2AK4	97	91.459	ENSMLUG00000010458	EIF2AK4	100	91.833	Myotis_lucifugus
ENSG00000128829	EIF2AK4	99	90.722	ENSNGAG00000018369	Eif2ak4	100	92.348	Nannospalax_galili
ENSG00000128829	EIF2AK4	94	61.488	ENSNBRG00000001908	EIF2AK4	99	61.433	Neolamprologus_brichardi
ENSG00000128829	EIF2AK4	99	96.968	ENSNLEG00000002209	EIF2AK4	98	98.630	Nomascus_leucogenys
ENSG00000128829	EIF2AK4	71	87.500	ENSMEUG00000014079	-	74	79.775	Notamacropus_eugenii
ENSG00000128829	EIF2AK4	94	86.011	ENSOPRG00000008540	EIF2AK4	94	86.011	Ochotona_princeps
ENSG00000128829	EIF2AK4	99	89.148	ENSODEG00000017099	EIF2AK4	99	90.398	Octodon_degus
ENSG00000128829	EIF2AK4	99	61.002	ENSONIG00000012130	EIF2AK4	99	60.864	Oreochromis_niloticus
ENSG00000128829	EIF2AK4	99	75.822	ENSOANG00000008313	EIF2AK4	99	76.904	Ornithorhynchus_anatinus
ENSG00000128829	EIF2AK4	99	94.451	ENSOCUG00000006506	EIF2AK4	99	94.512	Oryctolagus_cuniculus
ENSG00000128829	EIF2AK4	99	61.679	ENSORLG00000016934	EIF2AK4	100	62.045	Oryzias_latipes
ENSG00000128829	EIF2AK4	99	62.034	ENSORLG00020004104	EIF2AK4	99	61.737	Oryzias_latipes_hni
ENSG00000128829	EIF2AK4	98	42.609	ENSOMEG00000000491	EIF2AK4	99	66.046	Oryzias_melastigma
ENSG00000128829	EIF2AK4	99	94.336	ENSOGAG00000008865	EIF2AK4	99	94.275	Otolemur_garnettii
ENSG00000128829	EIF2AK4	99	93.415	ENSOARG00000020101	EIF2AK4	99	93.415	Ovis_aries
ENSG00000128829	EIF2AK4	99	99.817	ENSPPAG00000031553	EIF2AK4	99	99.817	Pan_paniscus
ENSG00000128829	EIF2AK4	99	90.354	ENSPPRG00000009516	EIF2AK4	99	90.293	Panthera_pardus
ENSG00000128829	EIF2AK4	98	89.938	ENSPTIG00000018354	EIF2AK4	98	89.876	Panthera_tigris_altaica
ENSG00000128829	EIF2AK4	100	99.879	ENSPTRG00000006910	EIF2AK4	100	99.879	Pan_troglodytes
ENSG00000128829	EIF2AK4	100	98.908	ENSPANG00000019508	EIF2AK4	100	98.908	Papio_anubis
ENSG00000128829	EIF2AK4	99	61.478	ENSPKIG00000002734	EIF2AK4	99	61.538	Paramormyrops_kingsleyae
ENSG00000128829	EIF2AK4	99	75.046	ENSPSIG00000009393	EIF2AK4	99	75.046	Pelodiscus_sinensis
ENSG00000128829	EIF2AK4	94	90.889	ENSPEMG00000018546	Eif2ak4	100	92.420	Peromyscus_maniculatus_bairdii
ENSG00000128829	EIF2AK4	100	50.146	ENSPMAG00000006975	EIF2AK4	99	50.504	Petromyzon_marinus
ENSG00000128829	EIF2AK4	99	83.585	ENSPCIG00000025256	EIF2AK4	99	84.211	Phascolarctos_cinereus
ENSG00000128829	EIF2AK4	99	60.501	ENSPFOG00000011015	EIF2AK4	99	61.051	Poecilia_formosa
ENSG00000128829	EIF2AK4	99	60.637	ENSPLAG00000021471	EIF2AK4	99	60.930	Poecilia_latipinna
ENSG00000128829	EIF2AK4	99	60.569	ENSPMEG00000007786	EIF2AK4	99	60.990	Poecilia_mexicana
ENSG00000128829	EIF2AK4	99	60.790	ENSPREG00000020280	EIF2AK4	99	61.156	Poecilia_reticulata
ENSG00000128829	EIF2AK4	99	99.176	ENSPPYG00000006341	EIF2AK4	100	94.663	Pongo_abelii
ENSG00000128829	EIF2AK4	96	84.175	ENSPCAG00000013314	EIF2AK4	95	84.175	Procavia_capensis
ENSG00000128829	EIF2AK4	99	94.505	ENSPCOG00000022591	EIF2AK4	99	94.505	Propithecus_coquereli
ENSG00000128829	EIF2AK4	99	89.072	ENSPVAG00000002184	EIF2AK4	99	86.081	Pteropus_vampyrus
ENSG00000128829	EIF2AK4	94	60.277	ENSPNYG00000000415	EIF2AK4	100	60.761	Pundamilia_nyererei
ENSG00000128829	EIF2AK4	99	62.221	ENSPNAG00000019708	EIF2AK4	99	62.221	Pygocentrus_nattereri
ENSG00000128829	EIF2AK4	99	90.409	ENSRNOG00000006027	Eif2ak4	99	90.409	Rattus_norvegicus
ENSG00000128829	EIF2AK4	100	95.027	ENSRBIG00000036650	EIF2AK4	100	95.027	Rhinopithecus_bieti
ENSG00000128829	EIF2AK4	100	98.848	ENSRROG00000023080	EIF2AK4	100	98.848	Rhinopithecus_roxellana
ENSG00000128829	EIF2AK4	99	97.804	ENSSBOG00000013374	EIF2AK4	100	97.804	Saimiri_boliviensis_boliviensis
ENSG00000128829	EIF2AK4	99	81.718	ENSSHAG00000010410	EIF2AK4	100	84.794	Sarcophilus_harrisii
ENSG00000128829	EIF2AK4	99	62.069	ENSSFOG00015009191	eif2ak4	99	62.349	Scleropages_formosus
ENSG00000128829	EIF2AK4	99	60.422	ENSSMAG00000006214	EIF2AK4	99	60.602	Scophthalmus_maximus
ENSG00000128829	EIF2AK4	99	62.007	ENSSDUG00000009681	EIF2AK4	99	62.245	Seriola_dumerili
ENSG00000128829	EIF2AK4	97	63.084	ENSSLDG00000004647	EIF2AK4	100	62.817	Seriola_lalandi_dorsalis
ENSG00000128829	EIF2AK4	94	75.353	ENSSARG00000010561	EIF2AK4	94	75.501	Sorex_araneus
ENSG00000128829	EIF2AK4	76	71.700	ENSSPUG00000019062	-	98	65.120	Sphenodon_punctatus
ENSG00000128829	EIF2AK4	99	61.686	ENSSPAG00000019379	EIF2AK4	98	61.529	Stegastes_partitus
ENSG00000128829	EIF2AK4	99	93.780	ENSSSCG00000039061	EIF2AK4	100	93.930	Sus_scrofa
ENSG00000128829	EIF2AK4	99	71.800	ENSTGUG00000011608	EIF2AK4	99	72.080	Taeniopygia_guttata
ENSG00000128829	EIF2AK4	99	62.742	ENSTRUG00000013993	EIF2AK4	99	62.477	Takifugu_rubripes
ENSG00000128829	EIF2AK4	99	61.585	ENSTNIG00000017450	EIF2AK4	99	61.585	Tetraodon_nigroviridis
ENSG00000128829	EIF2AK4	68	91.383	ENSTBEG00000007172	-	73	91.383	Tupaia_belangeri
ENSG00000128829	EIF2AK4	99	93.468	ENSTTRG00000000035	EIF2AK4	99	93.712	Tursiops_truncatus
ENSG00000128829	EIF2AK4	99	65.812	ENSUAMG00000023550	-	100	86.986	Ursus_americanus
ENSG00000128829	EIF2AK4	98	87.631	ENSUMAG00000013009	EIF2AK4	99	87.815	Ursus_maritimus
ENSG00000128829	EIF2AK4	97	87.321	ENSVPAG00000010280	EIF2AK4	100	87.259	Vicugna_pacos
ENSG00000128829	EIF2AK4	99	89.854	ENSVVUG00000026429	EIF2AK4	99	89.915	Vulpes_vulpes
ENSG00000128829	EIF2AK4	99	65.461	ENSXETG00000002204	eif2ak4	98	64.734	Xenopus_tropicalis
ENSG00000128829	EIF2AK4	79	61.111	ENSXCOG00000011227	EIF2AK4	99	60.309	Xiphophorus_couchianus
ENSG00000128829	EIF2AK4	99	60.930	ENSXMAG00000006832	EIF2AK4	100	59.935	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000049	tRNA binding	-	ISS	Function
GO:0000077	DNA damage checkpoint	-	IEA	Process
GO:0002230	positive regulation of defense response to virus by host	-	ISS	Process
GO:0002250	adaptive immune response	-	IEA	Process
GO:0002286	T cell activation involved in immune response	-	ISS	Process
GO:0002821	positive regulation of adaptive immune response	-	ISS	Process
GO:0004672	protein kinase activity	21873635.	IBA	Function
GO:0004674	protein serine/threonine kinase activity	-	ISS	Function
GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	21873635.	IBA	Function
GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	25329545.	IMP	Function
GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	10504407.	ISS	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005844	polysome	-	ISS	Component
GO:0006446	regulation of translational initiation	-	ISS	Process
GO:0006468	protein phosphorylation	-	ISS	Process
GO:0007050	cell cycle arrest	-	IEA	Process
GO:0007612	learning	-	ISS	Process
GO:0007616	long-term memory	-	ISS	Process
GO:0010998	regulation of translational initiation by eIF2 alpha phosphorylation	26102367.	IMP	Process
GO:0010998	regulation of translational initiation by eIF2 alpha phosphorylation	-	ISS	Process
GO:0019081	viral translation	-	ISS	Process
GO:0022626	cytosolic ribosome	21873635.	IBA	Component
GO:0022626	cytosolic ribosome	-	ISS	Component
GO:0032057	negative regulation of translational initiation in response to stress	-	ISS	Process
GO:0032792	negative regulation of CREB transcription factor activity	-	ISS	Process
GO:0034198	cellular response to amino acid starvation	25329545.	IMP	Process
GO:0034198	cellular response to amino acid starvation	-	ISS	Process
GO:0034644	cellular response to UV	-	ISS	Process
GO:0036492	eiF2alpha phosphorylation in response to endoplasmic reticulum stress	25329545.	IMP	Process
GO:0039520	induction by virus of host autophagy	-	ISS	Process
GO:0044828	negative regulation by host of viral genome replication	-	ISS	Process
GO:0045665	negative regulation of neuron differentiation	-	ISS	Process
GO:0045947	negative regulation of translational initiation	-	ISS	Process
GO:0046777	protein autophosphorylation	-	ISS	Process
GO:0051607	defense response to virus	-	IEA	Process
GO:0060259	regulation of feeding behavior	-	ISS	Process
GO:0060733	regulation of eIF2 alpha phosphorylation by amino acid starvation	26102367.	IMP	Process
GO:0060733	regulation of eIF2 alpha phosphorylation by amino acid starvation	-	ISS	Process
GO:0070417	cellular response to cold	25329545.	IMP	Process
GO:0071264	positive regulation of translational initiation in response to starvation	-	ISS	Process
GO:1900273	positive regulation of long-term synaptic potentiation	-	ISS	Process
GO:1990138	neuron projection extension	-	ISS	Process
GO:1990253	cellular response to leucine starvation	-	ISS	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
29865032	GCN2 is a potential prognostic biomarker for human papillary renal cell carcinoma.	Cancer Biomark	2018	Ge L	doi: 10.3233/CBM-170922.
25589675	Involvement of general control nonderepressible kinase 2 in cancer cell apoptosis by posttranslational mechanisms.	Mol Biol Cell	2015 Mar 15	Wei C	doi: 10.1091/mbc.E14-10-1438
27965097	BRAF-mutated cells activate GCN2-mediated integrated stress response as a cytoprotective mechanism in response to vemurafenib.	Biochem Biophys Res Commun	2017 Jan 22	Nagasawa I	doi: 10.1016/j.bbrc.2016.12.062
30061420	Inhibition of GCN2 sensitizes ASNS-low cancer cells to asparaginase by disrupting the amino acid response.	Proc Natl Acad Sci U S A	2018 Aug 14	Nakamura A	doi: 10.1073/pnas.1805523115

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr15	40034437	Frame_Shift_Ins	novel	*V1632Gfs10**	0.35
BLCA	chr15	39961850	Missense_Mutation	novel	F270L	0.21
BLCA	chr15	40034439	Missense_Mutation	novel	E1629D	0.26
BLCA	chr15	40009618	Missense_Mutation	NA	R1194T	0.24	HGTP_anticodon2
BLCA	chr15	39976795	Missense_Mutation	novel	E734K	0.21
BLCA	chr15	39949232	Silent	NA	Q159Q	0.24
BLCA	chr15	39992238	Intron	novel		0.47
BLCA	chr15	39976419	Silent	NA	Q608Q	0.51
BLCA	chr15	39976501	Missense_Mutation	novel	E636K	0.28
BLCA	chr15	39992361	Intron	novel		0.3
BLCA	chr15	39976747	Frame_Shift_Ins	novel	*S718Lfs74**	0.41
BLCA	chr15	39976748	Missense_Mutation	novel	S718W	0.42
BLCA	chr15	39976813	Missense_Mutation	novel	E740K	0.23
BLCA	chr15	39943457	Missense_Mutation	NA	E111G	0.26
BLCA	chr15	39965771	Silent	novel	L315L	0.05
BLCA	chr15	39973656	Silent	novel	F575F	0.48
BLCA	chr15	39976494	Frame_Shift_Ins	novel	*V637Gfs12**	0.17
BLCA	chr15	39949157	Silent	novel	L134L	0.23
BLCA	chr15	39973663	Missense_Mutation	novel	E578K	0.35
BLCA	chr15	40008166	Missense_Mutation	novel	E1183K	0.42	HGTP_anticodon2
BRCA	chr15	40003287	Missense_Mutation	NA	M1110I	0.1	HGTP_anticodon2
BRCA	chr15	40025991	Silent	NA	E1468E	0.12
BRCA	chr15	39992586	Intron	novel		0.17
BRCA	chr15	40032210	Missense_Mutation	novel	Q1567H	0.04
BRCA	chr15	39943426	Missense_Mutation	NA	E101K	0.24
BRCA	chr15	39953967	Nonsense_Mutation	NA	K193*	0.29
BRCA	chr15	39973655	Missense_Mutation	NA	F575S	0.27
BRCA	chr15	39967704	Missense_Mutation	rs763402151	E460Q	0.09
BRCA	chr15	40016533	Missense_Mutation	NA	K1264T	0.16	HGTP_anticodon2
BRCA	chr15	39939596	Missense_Mutation	novel	C79Y	0.13
BRCA	chr15	40009722	Missense_Mutation	NA	D1229N	0.25	HGTP_anticodon2
BRCA	chr15	40016538	Missense_Mutation	NA	D1266N	0.24	HGTP_anticodon2
BRCA	chr15	39973656	Silent	novel	F575F	0.08
BRCA	chr15	39992038	Intron	novel		0.13
BRCA	chr15	39967684	Missense_Mutation	NA	I453S	0.36
CESC	chr15	40003262	Missense_Mutation	novel	A1102V	0.11	HGTP_anticodon2
CESC	chr15	39992091	Intron	novel		0.44
CESC	chr15	40001212	Silent	rs61730023	S1049S	0.22
CESC	chr15	40026013	Missense_Mutation	NA	R1476C	0.4
CESC	chr15	39978118	Missense_Mutation	novel	E764K	0.25
CESC	chr15	39949218	Missense_Mutation	novel	Q155E	0.86
COAD	chr15	40016608	Missense_Mutation	NA	K1289T	0.34	HGTP_anticodon2
COAD	chr15	39992696	Intron	novel		0.44
COAD	chr15	40011294	Missense_Mutation	rs372621513	T1236M	0.21	HGTP_anticodon2
COAD	chr15	40011303	Missense_Mutation	NA	E1239G	0.19	HGTP_anticodon2
COAD	chr15	40001069	Frame_Shift_Del	NA	*P1003Hfs17**	0.32
COAD	chr15	40032178	Nonsense_Mutation	rs372637398	R1557*	0.33
COAD	chr15	39967632	Frame_Shift_Del	novel	*E436Kfs67**	0.08
COAD	chr15	39972905	Splice_Region	rs771179993		0.3
COAD	chr15	39985857	Missense_Mutation	rs570311740	T791M	0.1
COAD	chr15	39955739	Silent	novel	K238K	0.53
COAD	chr15	39990307	Frame_Shift_Del	NA	*L856Wfs7**	0.47
COAD	chr15	40029415	Silent	rs181699370	S1504S	0.14
COAD	chr15	40032200	Missense_Mutation	NA	N1564S	0.45
COAD	chr15	39949270	Splice_Site	NA	X171_splice	0.25
COAD	chr15	39967676	Silent	rs777111048	L450L	0.49
COAD	chr15	39953958	Frame_Shift_Del	NA	*R192Gfs43**	0.34
COAD	chr15	39939520	Missense_Mutation	NA	E54K	0.4
COAD	chr15	39967735	Missense_Mutation	novel	A470V	0.38
COAD	chr15	39973788	Intron	novel		0.38
COAD	chr15	40003301	Missense_Mutation	NA	P1115H	0.26	HGTP_anticodon2
COAD	chr15	40016593	Missense_Mutation	novel	I1284T	0.07	HGTP_anticodon2
COAD	chr15	40016628	Missense_Mutation	NA	E1296Q	0.2	HGTP_anticodon2
COAD	chr15	40025988	Silent	rs200983505	F1467F	0.19
COAD	chr15	39965781	Frame_Shift_Del	novel	*M321Wfs31**	0.14
COAD	chr15	40002699	Intron	novel		0.08
COAD	chr15	39967760	In_Frame_Del	novel	G479del	0.26
DLBC	chr15	39934155	5'UTR	novel		0.4
ESCA	chr15	40026013	Missense_Mutation	NA	R1476C	0.48
ESCA	chr15	39988026	Missense_Mutation	rs370476691	Q816R	0.5
ESCA	chr15	40034438	Frame_Shift_Del	NA	*K1631Rfs48**	0.38
GBM	chr15	39990287	Silent	NA	R847R	0.32
GBM	chr15	39949235	Missense_Mutation	novel	R160S	0.04
GBM	chr15	39967598	Missense_Mutation	novel	K424N	0.05
GBM	chr15	40003277	Missense_Mutation	novel	H1107L	0.1	HGTP_anticodon2
GBM	chr15	39955629	Nonsense_Mutation	NA	E202*	0.2
GBM	chr15	39949118	Splice_Region	novel	V121V	0.11
GBM	chr15	40032228	Missense_Mutation	novel	E1573D	0.1
GBM	chr15	40035209	3'UTR	novel		0.92
GBM	chr15	39992152	Intron	novel		0.07
GBM	chr15	39985805	Missense_Mutation	novel	D774H	0.19
GBM	chr15	39967530	Missense_Mutation	novel	L402F	0.32
GBM	chr15	39973862	Intron	novel		0.26
GBM	chr15	39992282	Intron	novel		0.31
GBM	chr15	40008038	Missense_Mutation	novel	E1140V	0.04	HGTP_anticodon2
GBM	chr15	39939524	Missense_Mutation	novel	I55N	0.09
GBM	chr15	39965714	Silent	novel	V296V	0.04
GBM	chr15	39965715	Missense_Mutation	novel	Y297H	0.04
GBM	chr15	40009671	Missense_Mutation	novel	H1212D	0.07	HGTP_anticodon2
GBM	chr15	40008169	Missense_Mutation	novel	I1184F	0.07	HGTP_anticodon2
HNSC	chr15	39967546	Missense_Mutation	novel	A407V	0.42
HNSC	chr15	40001153	Frame_Shift_Del	novel	*M1030Sfs18**	0.14
HNSC	chr15	39976741	Missense_Mutation	rs781268719	E716K	0.38
HNSC	chr15	40034390	Frame_Shift_Del	novel	*R1614Dfs5**	0.08
HNSC	chr15	39967850	Silent	novel	L508L	0.11
HNSC	chr15	39939513	Missense_Mutation	novel	E51D	0.28
HNSC	chr15	39973816	Intron	novel		0.41
HNSC	chr15	40021018	Silent	novel	D1431D	0.13
HNSC	chr15	39976584	Silent	novel	A663A	0.24
HNSC	chr15	39965760	Missense_Mutation	novel	E312Q	0.23
HNSC	chr15	40003228	Nonsense_Mutation	rs766436054	R1091*	0.29	HGTP_anticodon2
HNSC	chr15	39949150	Nonsense_Mutation	novel	S132*	0.06
KIRC	chr15	40016647	Missense_Mutation	NA	L1302S	0.2	HGTP_anticodon2
KIRC	chr15	40007057	Frame_Shift_Del	novel	L1134*	0.22	HGTP_anticodon2
KIRC	chr15	39976767	Silent	NA	P724P	0.29
KIRC	chr15	40002738	Frame_Shift_Ins	novel	*K1062Nfs10**	0.05	HGTP_anticodon2
KIRC	chr15	39992146	Intron	novel		0.32
KIRP	chr15	40032761	Missense_Mutation	NA	D1578G	0.21
KIRP	chr15	39934233	Missense_Mutation	novel	D13G	0.19
KIRP	chr15	40002658	Intron	novel		0.31
KIRP	chr15	39967598	Silent	novel	K424K	0.49
KIRP	chr15	39976723	Missense_Mutation	novel	E710K	0.2
LAML	chr15	40026017	Missense_Mutation	novel	V1477E	0.1
LAML	chr15	40035121	3'UTR	novel		0.23
LGG	chr15	39965822	Silent	NA	K332K	0.24
LGG	chr15	39973682	Missense_Mutation	NA	S584F	0.42
LGG	chr15	39949212	Missense_Mutation	NA	R153W	0.38
LGG	chr15	39965750	Silent	novel	V308V	0.48
LIHC	chr15	40029420	Missense_Mutation	rs754527586	N1506S	0.29
LIHC	chr15	40020964	Missense_Mutation	novel	I1413M	0.36
LIHC	chr15	39949160	Missense_Mutation	novel	S135R	0.22
LIHC	chr15	40008024	Splice_Region	novel		0.31
LIHC	chr15	39934173	5'UTR	novel		0.25
LIHC	chr15	39976448	Missense_Mutation	novel	V618A	0.09
LIHC	chr15	39972936	Missense_Mutation	novel	W528G	0.18
LIHC	chr15	39972937	Missense_Mutation	novel	W528L	0.19
LIHC	chr15	40020995	Missense_Mutation	novel	I1424V	0.41
LIHC	chr15	39976440	Silent	NA	C615C	0.54
LIHC	chr15	39967426	Missense_Mutation	novel	K367R	0.2
LUAD	chr15	39976768	Frame_Shift_Del	novel	*A725Pfs66**	0.18
LUAD	chr15	39973782	Intron	novel		0.53
LUAD	chr15	39961781	Splice_Region	novel		0.09
LUAD	chr15	39973741	Missense_Mutation	NA	V604I	0.17
LUAD	chr15	40001221	Silent	novel	L1052L	0.2
LUAD	chr15	39992230	Splice_Site	novel	X896_splice	0.25
LUAD	chr15	39934271	Nonsense_Mutation	NA	E26*	0.18
LUAD	chr15	39976827	Silent	NA	V744V	0.12
LUAD	chr15	39967488	Missense_Mutation	novel	A388S	0.08
LUAD	chr15	39976611	Silent	rs757912696	S672S	0.53
LUAD	chr15	39992792	Missense_Mutation	NA	T904S	0.41
LUSC	chr15	39972969	Missense_Mutation	novel	I539L	0.3
LUSC	chr15	39972993	Silent	novel	L547L	0.14
LUSC	chr15	40030364	Missense_Mutation	novel	F1523L	0.45
LUSC	chr15	39990360	Missense_Mutation	novel	D872H	0.28
LUSC	chr15	39988029	Missense_Mutation	rs748816386	G817E	0.12
LUSC	chr15	40032223	Frame_Shift_Ins	novel	E1573*	0.25
LUSC	chr15	39949253	Silent	novel	R166R	0.5
LUSC	chr15	40001018	Missense_Mutation	NA	D985N	0.34
LUSC	chr15	40026014	Missense_Mutation	novel	R1476H	0.61
LUSC	chr15	40016651	Silent	novel	K1303K	0.49
LUSC	chr15	40016671	Missense_Mutation	novel	Q1310R	0.21	HGTP_anticodon2
LUSC	chr15	39992110	Intron	novel		0.24
LUSC	chr15	40003246	Nonsense_Mutation	novel	E1097*	0.21	HGTP_anticodon2
LUSC	chr15	39949143	Missense_Mutation	rs767768823	V130M	0.05
LUSC	chr15	39973715	Missense_Mutation	novel	L595R	0.46
LUSC	chr15	39976738	Missense_Mutation	novel	G715S	0.57
LUSC	chr15	40032772	Nonsense_Mutation	novel	E1582*	0.54
LUSC	chr15	39990355	Missense_Mutation	novel	A870V	0.04
OV	chr15	39992038	Intron	novel		0.07
OV	chr15	40003207	Nonsense_Mutation	novel	C1084*	0.04	HGTP_anticodon2
OV	chr15	40021008	Missense_Mutation	novel	I1428N	0.1
OV	chr15	39934302	Nonsense_Mutation	novel	*A36_D37insSICKV**	0.12
OV	chr15	39992038	Intron	novel		0.29
OV	chr15	40016537	Frame_Shift_Del	novel	*D1266Ifs9**	0.12	HGTP_anticodon2
OV	chr15	39992290	Intron	novel		0.33
PAAD	chr15	39976803	Silent	novel	D736D	0.12
PAAD	chr15	40011294	Missense_Mutation	rs372621513	T1236M	0.24	HGTP_anticodon2
PRAD	chr15	39967750	Missense_Mutation	rs750136639	T475M	0.33
PRAD	chr15	40020979	Silent	NA	K1418K	0.06
PRAD	chr15	40002728	Missense_Mutation	rs201056702	R1059C	0.32
PRAD	chr15	39992325	Intron	novel		0.5
READ	chr15	39967719	Missense_Mutation	rs752398827	R465C	0.33
READ	chr15	40019096	Missense_Mutation	NA	P1357S	0.4	HGTP_anticodon2
READ	chr15	39934232	Missense_Mutation	novel	D13N	1
READ	chr15	39973659	Missense_Mutation	novel	F576L	0.09
READ	chr15	40020911	Missense_Mutation	novel	S1396P	0.17
READ	chr15	39973717	Missense_Mutation	NA	L596I	0.4
READ	chr15	40025988	Silent	rs200983505	F1467F	0.53
SARC	chr15	40020949	Silent	novel	S1408S	0.08
SARC	chr15	39996970	Missense_Mutation	novel	D925Y	0.15
SKCM	chr15	40022521	Splice_Region	novel	S1435S	0.34
SKCM	chr15	40035181	3'UTR	novel		0.4
SKCM	chr15	39961822	Missense_Mutation	NA	S261F	0.3
SKCM	chr15	40008076	Missense_Mutation	NA	P1153S	0.21	HGTP_anticodon2
SKCM	chr15	40009682	Silent	NA	I1215I	0.34
SKCM	chr15	40020912	Missense_Mutation	rs767175226	S1396F	0.25
SKCM	chr15	40001001	Missense_Mutation	rs776612590	S979F	0.42
SKCM	chr15	39967714	Missense_Mutation	NA	R463Q	0.29
SKCM	chr15	39967514	Silent	NA	P396P	0.13
SKCM	chr15	39955628	Missense_Mutation	NA	L201F	0.79
SKCM	chr15	40035085	3'UTR	novel		0.21
SKCM	chr15	40035086	3'UTR	novel		0.23
SKCM	chr15	39973693	Missense_Mutation	NA	I588L	0.49
SKCM	chr15	40001185	Silent	rs777664600	S1040S	0.15
SKCM	chr15	39990288	Missense_Mutation	rs768944097	D848N	0.23
SKCM	chr15	40029414	Missense_Mutation	novel	S1504F	0.32
SKCM	chr15	39967517	Silent	NA	I397I	0.38
SKCM	chr15	39943421	Nonsense_Mutation	NA	S99*	0.56
SKCM	chr15	39967639	Missense_Mutation	novel	T438I	0.47
SKCM	chr15	39967640	Silent	rs754630320	T438T	0.47
SKCM	chr15	39949191	Missense_Mutation	NA	H146Y	0.51
SKCM	chr15	40003227	Silent	rs758365298	P1090P	0.25
SKCM	chr15	39992846	Nonsense_Mutation	novel	Q922*	0.32
SKCM	chr15	39967719	Missense_Mutation	rs752398827	R465C	0.46
SKCM	chr15	40003301	Missense_Mutation	rs774906916	P1115L	0.24	HGTP_anticodon2
SKCM	chr15	39955634	Silent	rs56302914	I203I	0.28
SKCM	chr15	39934324	Silent	rs775764964	P43P	0.21
SKCM	chr15	40017164	Silent	novel	F1329F	0.41
SKCM	chr15	39992758	Intron	novel		0.39
SKCM	chr15	39998738	Missense_Mutation	rs201824903	S959L	0.54
STAD	chr15	39965822	Silent	NA	K332K	0.21
STAD	chr15	40001111	Missense_Mutation	novel	H1016Y	0.13
STAD	chr15	40026013	Missense_Mutation	NA	R1476C	0.09
STAD	chr15	40016665	Missense_Mutation	NA	K1308R	0.22	HGTP_anticodon2
STAD	chr15	39967534	Missense_Mutation	rs765950157	R403H	0.4
STAD	chr15	39988067	Nonsense_Mutation	rs370269120	R830*	0.24
STAD	chr15	39973670	Missense_Mutation	novel	Q580R	0.47
STAD	chr15	40025989	Missense_Mutation	novel	E1468K	0.4
STAD	chr15	39953958	Frame_Shift_Del	NA	*R192Gfs43**	0.31
STAD	chr15	39992178	Missense_Mutation	NA	D879H	0.18
STAD	chr15	40034438	Frame_Shift_Del	NA	*K1631Rfs48**	0.41
STAD	chr15	39990307	Frame_Shift_Del	NA	*L856Wfs7**	0.09
STAD	chr15	40008039	Silent	NA	E1140E	0.33
STAD	chr15	39990307	Frame_Shift_Del	NA	*L856Wfs7**	0.27
STAD	chr15	40017215	Silent	rs771324436	L1346L	0.24
STAD	chr15	39992032	Intron	novel		0.57
STAD	chr15	39976554	Silent	novel	N653N	0.41
STAD	chr15	40026021	Silent	novel	L1478L	0.06
STAD	chr15	39961861	Missense_Mutation	NA	S274I	0.1
STAD	chr15	39967853	Silent	NA	P509P	0.27
STAD	chr15	40030395	Missense_Mutation	rs559599794	I1533T	0.21
UCEC	chr15	39967445	Silent	rs373182039	I373I	0.47
UCEC	chr15	39965758	Missense_Mutation	rs762607194	Y311C	0.11
UCEC	chr15	39991916	Intron	novel		0.17
UCEC	chr15	40008030	Silent	novel	Y1137Y	0.26
UCEC	chr15	39961791	Missense_Mutation	rs200534017	R251C	0.35
UCEC	chr15	39939542	Missense_Mutation	novel	P61L	0.39
UCEC	chr15	39949238	Silent	novel	L161L	0.19
UCEC	chr15	40034408	Missense_Mutation	novel	V1619A	0.4
UCEC	chr15	40001201	Missense_Mutation	novel	T1046A	0.46
UCEC	chr15	40001212	Silent	rs61730023	S1049S	0.34
UCEC	chr15	40003312	Missense_Mutation	novel	R1119W	0.32	HGTP_anticodon2
UCEC	chr15	39967404	Missense_Mutation	rs750055012	R360C	0.42
UCEC	chr15	39992694	Intron	novel		0.46
UCEC	chr15	40017110	Splice_Region	NA	V1311V	0.1
UCEC	chr15	39972980	Missense_Mutation	novel	Q542H	0.24
UCEC	chr15	40017111	Missense_Mutation	novel	L1312M	0.2	HGTP_anticodon2
UCEC	chr15	40035083	Silent	novel	*1650*	0.24
UCEC	chr15	40009658	Missense_Mutation	novel	K1207N	0.32	HGTP_anticodon2
UCEC	chr15	39967403	Silent	novel	V359V	0.34
UCEC	chr15	39990307	Frame_Shift_Del	NA	*L856Wfs7**	0.31
UCEC	chr15	39967639	Missense_Mutation	novel	T438I	0.3
UCEC	chr15	39988045	Silent	rs760848269	T822T	0.32
UCEC	chr15	40001113	Silent	rs747667739	H1016H	0.5
UCEC	chr15	40017109	Missense_Mutation	novel	V1311A	0.23	HGTP_anticodon2
UCEC	chr15	40026013	Missense_Mutation	NA	R1476C	0.32
UCEC	chr15	39965692	Missense_Mutation	novel	D289G	0.36
UCEC	chr15	39998738	Missense_Mutation	rs201824903	S959L	0.34
UCEC	chr15	40026069	Silent	novel	V1494V	0.47
UCEC	chr15	39992297	Intron	novel		0.43
UCEC	chr15	39961842	Missense_Mutation	novel	L268M	0.56
UCEC	chr15	39976839	Silent	novel	S748S	0.33
UCEC	chr15	39992121	Intron	novel		0.25
UCEC	chr15	39978148	Splice_Site	rs780086415	X773_splice	0.12
UCEC	chr15	39953958	Frame_Shift_Del	NA	*R192Gfs43**	0.44
UCEC	chr15	39967466	Silent	novel	E380E	0.29
UCEC	chr15	40020912	Missense_Mutation	NA	S1396Y	0.45
UCEC	chr15	40032789	Missense_Mutation	novel	F1587L	0.45
UCEC	chr15	39939597	Silent	NA	C79C	0.29
UCEC	chr15	39990366	Missense_Mutation	NA	L874I	0.21
UCEC	chr15	40016638	Missense_Mutation	novel	V1299A	0.14	HGTP_anticodon2
UCEC	chr15	39998738	Missense_Mutation	rs201824903	S959L	0.28
UCEC	chr15	40026014	Missense_Mutation	novel	R1476H	0.3
UCEC	chr15	39967640	Silent	rs754630320	T438T	0.32
UCEC	chr15	39992850	Splice_Site	novel	X922_splice	0.43
UCEC	chr15	40001212	Silent	rs61730023	S1049S	0.2
UCEC	chr15	40030414	Silent	rs199783641	P1539P	0.43
UCEC	chr15	39967619	Silent	novel	V431V	0.45
UCEC	chr15	40011326	Missense_Mutation	novel	L1247M	0.41	HGTP_anticodon2
UCEC	chr15	39976824	Silent	rs780148803	G743G	0.36
UCEC	chr15	40008129	Silent	novel	S1170S	0.05
UCEC	chr15	40008161	Missense_Mutation	novel	I1181S	0.32	HGTP_anticodon2
UCEC	chr15	40029430	Silent	NA	V1509V	0.31
UCEC	chr15	39973014	Missense_Mutation	novel	D554Y	0.26
UCEC	chr15	40034343	Missense_Mutation	novel	Q1597H	0.27
UCEC	chr15	40001140	Silent	novel	K1025K	0.3
UCEC	chr15	40032238	Splice_Site	NA	X1576_splice	0.25
UCEC	chr15	39939539	Missense_Mutation	rs776089345	Y60C	0.28
UCEC	chr15	39967526	Missense_Mutation	novel	H400Q	0.09
UCEC	chr15	39934251	Missense_Mutation	NA	Y19C	0.44
UCEC	chr15	40032204	Silent	novel	L1565L	0.33
UCEC	chr15	40008067	Silent	NA	R1150R	0.4
UCEC	chr15	40011317	Missense_Mutation	NA	F1244V	0.5	HGTP_anticodon2
UCEC	chr15	39992394	Intron	novel		0.46
UCEC	chr15	39967719	Missense_Mutation	rs752398827	R465C	0.12
UCEC	chr15	40001045	Missense_Mutation	novel	E994Q	0.32
UCEC	chr15	39992180	Silent	NA	D879D	0.27
UCEC	chr15	39992638	Intron	novel		0.38
UCEC	chr15	40017212	Silent	NA	I1345I	0.31
UCEC	chr15	40034421	Missense_Mutation	NA	I1623M	0.34
UCEC	chr15	39934288	Missense_Mutation	novel	E31D	0.23
UCEC	chr15	39967671	Missense_Mutation	rs371395483	R449C	0.23
UCEC	chr15	39976431	Silent	novel	D612D	0.31
UCEC	chr15	39985847	Missense_Mutation	rs778425049	P788S	0.13
UCEC	chr15	39988037	Nonsense_Mutation	rs774163084	R820*	0.41
UCEC	chr15	39991867	Intron	novel		0.16
UCEC	chr15	39992325	Intron	novel		0.23
UCEC	chr15	39992729	Intron	novel		0.21
UCEC	chr15	40007064	Nonsense_Mutation	rs587777105	R1136*	0.13	HGTP_anticodon2
UCEC	chr15	40008055	Missense_Mutation	rs768947886	R1146C	0.38	HGTP_anticodon2
UCEC	chr15	39939507	Splice_Region	novel	V49V	0.47
UCEC	chr15	39978108	Silent	novel	I760I	0.27
UCEC	chr15	39996985	Nonsense_Mutation	novel	G930*	0.53
UCEC	chr15	39967716	Missense_Mutation	novel	V464F	0.38
UCEC	chr15	39992158	Intron	novel		0.36
UCEC	chr15	40034438	Frame_Shift_Del	NA	*K1631Rfs48**	0.55
UCEC	chr15	39967651	Missense_Mutation	rs202241343	T442M	0.4
UCEC	chr15	39978084	Silent	novel	A752A	0.14
UCEC	chr15	39976453	Missense_Mutation	novel	R620C	0.38
UCEC	chr15	40020946	Missense_Mutation	novel	M1407I	0.43
UCEC	chr15	40026013	Missense_Mutation	NA	R1476C	0.3

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.2222	0.079424
CESC	DEL	0.1966	0.00049652
COAD	DEL	0.3525	2.3878e-07
GBM	DEL	0.2201	3.453e-12
HNSC	DEL	0.1667	0.11567
KICH	AMP	0.2727	0.21756
KIRP	DEL	0.1111	0.2062
LUAD	DEL	0.4012	6.8561e-07
LUSC	DEL	0.2735	5.9764e-05
MESO	DEL	0.3103	4.5411e-10
PAAD	DEL	0.1304	0.13216
READ	DEL	0.4303	0.025797
SARC	DEL	0.1984	0.18974
UCEC	DEL	0.2338	7.1012e-08
UCS	DEL	0.6786	4.9548e-10

Survival Analysis

Cancer	P-value	Q-value
STAD	0.011	Kaplan-Meier Survival Analysis
SARC	0.02	Kaplan-Meier Survival Analysis
MESO	0.034	Kaplan-Meier Survival Analysis
SKCM	0.037	Kaplan-Meier Survival Analysis
COAD	0.021	Kaplan-Meier Survival Analysis
PAAD	0.017	Kaplan-Meier Survival Analysis
BLCA	0.0093	Kaplan-Meier Survival Analysis
CESC	0.024	Kaplan-Meier Survival Analysis
LAML	0.0031	Kaplan-Meier Survival Analysis
KICH	0.015	Kaplan-Meier Survival Analysis
UCEC	0.011	Kaplan-Meier Survival Analysis
GBM	0.048	Kaplan-Meier Survival Analysis