EuRBPDB

Description

Ensembl ID: ENSG00000128951 (Gene tree)
Gene ID: 1854
Gene Symbol: DUT
Alias: dUTPase
Full Name: deoxyuridine triphosphatase
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 12,363 bases
Position: chr15:48,331,011-48,343,373
Accession: 3078
RBP type: non-canonical RBP
Summary: This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000558978	DUT-206	1171	-	ENSP00000452814	226 (aa)	-	H0YKI0
ENST00000559416	DUT-207	635	-	ENSP00000454183	167 (aa)	-	H0YNW5
ENST00000558813	DUT-205	769	-	ENSP00000453717	141 (aa)	-	A0A0C4DGL3
ENST00000558367	DUT-203	627	-	ENSP00000453683	107 (aa)	-	H0YMP1
ENST00000559852	DUT-209	340	-	-	- (aa)	-	-
ENST00000561350	DUT-211	201	-	-	- (aa)	-	-
ENST00000558472	DUT-204	724	-	ENSP00000452749	221 (aa)	-	H0YKC5
ENST00000559540	DUT-208	1441	-	ENSP00000454041	143 (aa)	-	H0YNJ9
ENST00000559935	DUT-210	569	-	ENSP00000453667	133 (aa)	-	H0YMM5
ENST00000331200	DUT-201	2147	-	ENSP00000370376	252 (aa)	-	P33316
ENST00000455976	DUT-202	1935	-	ENSP00000405160	164 (aa)	-	P33316

Gene Model

Pathways

Pathway ID	Pathway Name	Source
hsa00240	Pyrimidine metabolism	KEGG
hsa00983	Drug metabolism - other enzymes	KEGG
hsa01100	Metabolic pathways	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000128951	Myocardial Infarction	9.4555228E-004	-
ENSG00000128951	Platelet Function Tests	1.0109800E-005	-
ENSG00000128951	Adiponectin	9.0430000E-005	-
ENSG00000128951	Adiponectin	3.1900000E-005	-
ENSG00000128951	Adiponectin	2.8710000E-006	-
ENSG00000128951	Adiponectin	3E-6	18464913

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000128951	rs11637235	15	48340956	?	Protein quantitative trait loci	18464913			EFO_0004502

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000128951	DUT	99	92.143	ENSMUSG00000027203	Dut	100	86.585	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000287	magnesium ion binding	21873635.	IBA	Function
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0004170	dUTP diphosphatase activity	21873635.	IBA	Function
GO:0005515	protein binding	16189514.19060904.	IPI	Function
GO:0005634	nucleus	8631816.	TAS	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005739	mitochondrion	-	IEA	Component
GO:0006139	nucleobase-containing compound metabolic process	1325640.	TAS	Process
GO:0006226	dUMP biosynthetic process	21873635.	IBA	Process
GO:0006226	dUMP biosynthetic process	-	IEA	Process
GO:0006260	DNA replication	1325640.	TAS	Process
GO:0015949	nucleobase-containing small molecule interconversion	-	TAS	Process
GO:0046081	dUTP catabolic process	21873635.	IBA	Process
GO:0070062	extracellular exosome	20458337.	HDA	Component