EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000129116 (Gene tree)
Gene ID: 23022
Gene Symbol: PALLD
Alias: KIAA0992|SIH002|CGI-151
Full Name: palladin, cytoskeletal associated protein
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 431,394 bases
Position: chr4:168,497,064-168,928,457
Accession: 17068
RBP type: non-canonical RBP
Summary: This gene encodes a cytoskeletal protein that is required for organizing the actin cytoskeleton. The protein is a component of actin-containing microfilaments, and it is involved in the control of cell shape, adhesion, and contraction. Polymorphisms in this gene are associated with a susceptibility to pancreatic cancer type 1, and also with a risk for myocardial infarction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000504519	PALLD-205	570	-	ENSP00000424121	83 (aa)	-	D6RBH5
ENST00000511611	PALLD-212	533	-	-	- (aa)	-	-
ENST00000511948	PALLD-214	576	-	ENSP00000423640	28 (aa)	-	D6R948
ENST00000503290	PALLD-203	628	-	ENSP00000425729	160 (aa)	-	H0YA05
ENST00000511682	PALLD-213	661	-	-	- (aa)	-	-
ENST00000513187	PALLD-216	558	-	-	- (aa)	-	-
ENST00000508898	PALLD-210	2320	-	ENSP00000423063	512 (aa)	-	H0Y952
ENST00000507325	PALLD-207	589	-	-	- (aa)	-	-
ENST00000513245	PALLD-217	565	-	ENSP00000422016	71 (aa)	-	D6R9Z5
ENST00000261509	PALLD-201	5809	XM_011531769	ENSP00000261509	1106 (aa)	XP_011530071	Q8WX93
ENST00000393726	PALLD-202	817	-	ENSP00000377327	164 (aa)	-	F8WA26
ENST00000507735	PALLD-209	4392	XM_024453940	ENSP00000424016	672 (aa)	XP_024309708	Q8WX93
ENST00000512127	PALLD-215	2958	XM_005262866	ENSP00000426947	777 (aa)	XP_005262923	Q8WX93
ENST00000505667	PALLD-206	3637	XM_005262861	ENSP00000425556	1123 (aa)	XP_005262918	Q8WX93
ENST00000503457	PALLD-204	607	-	ENSP00000424288	96 (aa)	-	D6RBB1
ENST00000507699	PALLD-208	3829	-	-	- (aa)	-	-
ENST00000649826	PALLD-218	1151	-	ENSP00000497440	384 (aa)	-	-
ENST00000510998	PALLD-211	545	-	ENSP00000422135	90 (aa)	-	D6R9F5

Gene Model

Click here to download ENSG00000129116's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000129116	Glucose	8.48377672224651E-14	17903298
ENSG00000129116	Insulin	5.64417553629664E-8	17903298
ENSG00000129116	Cholesterol	2.58648363783964E-8	17903299
ENSG00000129116	Cholesterol, HDL	3.19643899537869E-5	17903299
ENSG00000129116	Hematocrit	3.04118527930833E-8	17903294
ENSG00000129116	Hemoglobins	3.37397703456185E-28	17903294
ENSG00000129116	Hemoglobins	7.91996754995033E-6	17903294
ENSG00000129116	Hemoglobins	8.01332242137793E-7	17903294
ENSG00000129116	Blood Proteins	6.1094322939579E-10	17903294
ENSG00000129116	Angiography	5.21952671909285E-7	17903301
ENSG00000129116	Iron	5.7530000E-004	19880490
ENSG00000129116	Stroke	4.2732356E-004	19369658
ENSG00000129116	Personality	7.882e-005	-
ENSG00000129116	Personality	2.717e-005	-
ENSG00000129116	Body Height	8.8570000E-005	-
ENSG00000129116	Body Height	7.9480000E-005	-
ENSG00000129116	Body Height	3.3840000E-005	-
ENSG00000129116	Body Height	3.7740000E-005	-
ENSG00000129116	Body Height	4.4660000E-005	-
ENSG00000129116	Body Height	6.6010000E-005	-
ENSG00000129116	Body Height	3.5100000E-006	-
ENSG00000129116	Erythrocyte Indices	2.4350000E-005	-
ENSG00000129116	Erythrocyte Indices	3.5190000E-005	-
ENSG00000129116	Hematocrit	4.6390000E-005	-
ENSG00000129116	Hematocrit	9.8000000E-005	-
ENSG00000129116	Platelet Function Tests	1.3300000E-006	-
ENSG00000129116	Platelet Function Tests	1.4181600E-005	-
ENSG00000129116	Child Development Disorders, Pervasive	1.1160000E-005	-
ENSG00000129116	Bacteremia	4E-6	27236921
ENSG00000129116	Coronary Artery Bypass	4E-6	25881214
ENSG00000129116	Vascular Grafting	4E-6	25881214
ENSG00000129116	Diabetes Mellitus, Type 2	8E-7	26915486
ENSG00000129116	Glycosylation End Products, Advanced	8E-7	26915486
ENSG00000129116	Polychlorinated Biphenyls	8E-7	25839716
ENSG00000129116	iloperidone	3E-6	18521091

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000129116	rs1500801	4	168747226	?	Bacteremia	27236921	[NR]	1.64	EFO_0003033
ENSG00000129116	rs17054480	4	168687639	?	Advanced glycation end-product levels	26915486	[0.19-0.43] unit decrease	0.312	EFO_0007819\|EFO_0001360
ENSG00000129116	rs7696431	4	168766574	T	Coronary artery disease	29212778	[0.023-0.047] unit increase	0.035	EFO_0000378
ENSG00000129116	rs7696431	4	168766574	T	Coronary artery disease	29212778	[0.023-0.047] unit increase	0.0351	EFO_0000378
ENSG00000129116	rs7696431	4	168766574	T	Coronary artery disease	29212778	[0.02-0.042] unit increase	0.0311	EFO_0000378
ENSG00000129116	rs1566497	4	168795997	A	Pulse pressure	28135244	[0.18-0.29] unit increase	0.236	EFO_0005763
ENSG00000129116	rs116609577	4	168799231	C	Interferon gamma levels	27989323	[0.17-0.38] SD units decrease	0.2726	EFO_0008165
ENSG00000129116	rs17054392	4	168609107	C	Response to iloperidone treatment (QT prolongation)	18521091			GO_0036287
ENSG00000129116	rs113026070	4	168785846	?	Polychlorinated biphenyl levels	25839716	[0.16-0.36] unit decrease	0.26	EFO_0007042
ENSG00000129116	rs6854137	4	168807085	A	Vein graft stenosis in coronary artery bypass grafting	25881214			EFO_0003776\|EFO_0007051
ENSG00000129116	rs10019193	4	168526369	?	Adolescent idiopathic scoliosis	30019117			EFO_0005423
ENSG00000129116	rs13129779	4	168804876	?	Systolic blood pressure	30595370			EFO_0006335
ENSG00000129116	rs62334289	4	168770113	A	Pulse pressure	30578418	[0.17-0.27] mmHg increase	0.2171	EFO_0005763
ENSG00000129116	rs869398	4	168766918	A	Systolic blood pressure	30578418	[0.14-0.27] mmHg increase	0.2082	EFO_0006335
ENSG00000129116	rs869396	4	168766849	C	Pulse pressure	27841878	unit increase	0.222	EFO_0005763

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000129116's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001726	ruffle	-	IEA	Component
GO:0002102	podosome	-	IEA	Component
GO:0003334	keratinocyte development	-	IEA	Process
GO:0003382	epithelial cell morphogenesis	-	IEA	Process
GO:0003779	actin binding	-	IEA	Function
GO:0005515	protein binding	11598191.16125169.	IPI	Function
GO:0005634	nucleus	11598191.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005884	actin filament	11598191.	IDA	Component
GO:0005886	plasma membrane	21873635.	IBA	Component
GO:0005886	plasma membrane	-	IDA	Component
GO:0005925	focal adhesion	21423176.	HDA	Component
GO:0007010	cytoskeleton organization	11598191.	NAS	Process
GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	21873635.	IBA	Process
GO:0007411	axon guidance	21873635.	IBA	Process
GO:0015629	actin cytoskeleton	-	IDA	Component
GO:0016477	cell migration	-	IEA	Process
GO:0030018	Z disc	-	IEA	Component
GO:0030027	lamellipodium	-	IEA	Component
GO:0030036	actin cytoskeleton organization	-	IEA	Process
GO:0030424	axon	21873635.	IBA	Component
GO:0030426	growth cone	-	IEA	Component
GO:0051371	muscle alpha-actinin binding	16125169.	TAS	Function
GO:0070593	dendrite self-avoidance	21873635.	IBA	Process
GO:0098632	cell-cell adhesion mediator activity	21873635.	IBA	Function

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
20436683	Isoform-specific upregulation of palladin in human and murine pancreas tumors.	PLoS One	2010 Apr 26	Goicoechea SM	doi: 10.1371/journal.pone.0010347.
26200861	Palladin mediates stiffness-induced fibroblast activation in the tumor microenvironment.	Biophys J	2015 Jul 21	McLane JS	doi: 10.1016/j.bpj.2015.06.033.
24989798	Actin-associated protein palladin promotes tumor cell invasion by linking extracellular matrix degradation to cell cytoskeleton.	Mol Biol Cell	2014 Sep 1	von Nandelstadh P	doi: 10.1091/mbc.E13-11-0667
17194196	Palladin mutation causes familial pancreatic cancer and suggests a new cancer mechanism.	PLoS Med	2006 Dec	Pogue-Geile KL	-
19336541	Absence of deleterious palladin mutations in patients with familial pancreatic cancer.	Cancer Epidemiol Biomarkers Prev	2009 Apr	Klein AP	doi: 10.1158/1055-9965.EPI-09-0056
20471940	The actin-bundling protein palladin is an Akt1-specific substrate that regulates breast cancer cell migration.	Mol Cell	2010 May 14	Chin YR	doi: 10.1016/j.molcel.2010.02.031.
17415588	The P239S palladin variant does not account for a significant fraction of hereditary or early onset pancreas cancer.	Hum Genet	2007 Jun	Zogopoulos G	-
26973246	Twist1-induced activation of human fibroblasts promotes matrix stiffness by upregulating palladin and collagen α1(VI).	Oncogene	2016 Oct 6	Garc??a-Palmero I	doi: 10.1038/onc.2016.57

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr4	168711915	Missense_Mutation	novel	K652N	0.06
ACC	chr4	168711916	Missense_Mutation	novel	P653T	0.06
BLCA	chr4	168898493	Missense_Mutation	novel	E751Q	0.26
BLCA	chr4	168511793	Missense_Mutation	novel	N97D	0.08
BLCA	chr4	168891056	Missense_Mutation	novel	P700L	0.09
BLCA	chr4	168898525	Silent	rs753753166	L761L	0.21
BLCA	chr4	168681372	Silent	novel	F376F	0.57
BLCA	chr4	168512318	Missense_Mutation	NA	R272G	0.1
BLCA	chr4	168681377	Nonsense_Mutation	NA	S378*	0.1
BLCA	chr4	168915923	Missense_Mutation	novel	D916H	0.24
BLCA	chr4	168512406	Missense_Mutation	rs370466913	R301Q	0.37
BLCA	chr4	168709069	Missense_Mutation	novel	D515N	0.31
BLCA	chr4	168898568	Missense_Mutation	NA	E776K	0.17
BRCA	chr4	168690621	Missense_Mutation	rs187404166	V452M	0.34
BRCA	chr4	168511526	Missense_Mutation	novel	E8Q	0.45
BRCA	chr4	168511630	Silent	novel	S42S	0.2
BRCA	chr4	168511931	Missense_Mutation	rs780911413	R143C	0.35
BRCA	chr4	168512070	Missense_Mutation	NA	R189T	0.15
BRCA	chr4	168926368	3'Flank	NA		0.35
BRCA	chr4	168683002	Missense_Mutation	novel	Q387K	0.09
BRCA	chr4	168926235	3'UTR	novel		0.07
BRCA	chr4	168925069	Missense_Mutation	novel	D1117Y	0.07
BRCA	chr4	168711788	Missense_Mutation	rs758309395	T610M	0.27
BRCA	chr4	168668365	Missense_Mutation	novel	E362Q	0.2
CESC	chr4	168921641	Silent	NA	L986L	0.26
CESC	chr4	168898618	Missense_Mutation	NA	M792I	0.11
CESC	chr4	168928127	3'Flank	novel		0.33
CESC	chr4	168903814	Nonsense_Mutation	novel	Q844*	0.34
CESC	chr4	168915986	Missense_Mutation	NA	L937V	0.37
CESC	chr4	168512236	Silent	NA	Q244Q	0.34
CESC	chr4	168928052	3'Flank	novel		0.1
CESC	chr4	168511911	Missense_Mutation	novel	S136N	0.15
CESC	chr4	168690625	Missense_Mutation	rs142714330	A453V	0.16
CESC	chr4	168898422	Intron	novel		0.21
CHOL	chr4	168691286	Missense_Mutation	novel	E499K	0.14
CHOL	chr4	168903784	Missense_Mutation	novel	I834V	0.67
CHOL	chr4	168926390	3'Flank	novel		0.1
COAD	chr4	168511531	Silent	NA	S9S	0.3
COAD	chr4	168511958	Missense_Mutation	NA	V152I	0.38
COAD	chr4	168903893	Missense_Mutation	NA	A870D	0.31
COAD	chr4	168512365	Silent	NA	R287R	0.11
COAD	chr4	168511643	Missense_Mutation	NA	R47W	0.5
COAD	chr4	168512239	Silent	NA	D245D	0.19
COAD	chr4	168511452	5'UTR	novel		0.41
COAD	chr4	168512140	Silent	NA	S212S	0.16
COAD	chr4	168690693	Missense_Mutation	rs535947672	R476W	0.18
COAD	chr4	168898657	Silent	NA	I805I	0.18
COAD	chr4	168894766	Intron	NA		0.38
COAD	chr4	168894622	Missense_Mutation	NA	A715V	0.49
ESCA	chr4	168683104	Splice_Site	novel	X420_splice	0.16
ESCA	chr4	168690694	Missense_Mutation	rs768538351	R476Q	0.14
ESCA	chr4	168891057	Splice_Region	novel	P700P	0.09
GBM	chr4	168898498	Nonsense_Mutation	novel	Y752*	0.07
GBM	chr4	168898571	Missense_Mutation	novel	S777P	0.04
GBM	chr4	168924413	Nonsense_Mutation	novel	R1073*	0.42
GBM	chr4	168511441	5'UTR	novel		0.08
GBM	chr4	168511426	5'UTR	novel		0.2
GBM	chr4	168711878	Missense_Mutation	novel	L640R	0.24
GBM	chr4	168668355	Missense_Mutation	novel	E358D	0.34
GBM	chr4	168690621	Missense_Mutation	rs187404166	V452M	0.08
GBM	chr4	168711807	Silent	novel	S616S	0.61
GBM	chr4	168891051	Silent	novel	G698G	0.09
GBM	chr4	168711830	Missense_Mutation	novel	N624S	0.14
HNSC	chr4	168711590	Missense_Mutation	novel	E544V	0.24
HNSC	chr4	168924321	Missense_Mutation	NA	Y1042C	0.29
HNSC	chr4	168709129	Missense_Mutation	novel	Q535K	0.35
HNSC	chr4	168711677	Missense_Mutation	NA	S573F	0.46
HNSC	chr4	168690693	Missense_Mutation	rs535947672	R476W	0.16
HNSC	chr4	168690718	Missense_Mutation	novel	S484F	0.17
KIRC	chr4	168894754	Intron	novel		0.33
KIRC	chr4	168711922	Missense_Mutation	NA	L655I	0.34
KIRP	chr4	168921532	Splice_Site	novel	X951_splice	0.33
LAML	chr4	168915896	Missense_Mutation	novel	P907S	0.06
LGG	chr4	168511729	Silent	novel	L75L	0.11
LGG	chr4	168709126	Missense_Mutation	novel	A534T	0.36
LGG	chr4	168898669	Missense_Mutation	novel	M809I	0.06
LGG	chr4	168921664	Missense_Mutation	novel	R994H	0.43
LIHC	chr4	168898405	Intron	novel		0.36
LIHC	chr4	168913987	Missense_Mutation	novel	P895A	0.07
LIHC	chr4	168511705	Silent	novel	I67I	0.27
LIHC	chr4	168903893	Missense_Mutation	NA	A870D	0.46
LIHC	chr4	168894620	Silent	novel	G714G	0.28
LIHC	chr4	168681336	Silent	novel	A364A	0.45
LUAD	chr4	168668350	Missense_Mutation	NA	A357S	0.74
LUAD	chr4	168711804	Silent	NA	P615P	0.27
LUAD	chr4	168921629	Silent	NA	G982G	0.48
LUAD	chr4	168915962	Missense_Mutation	NA	H929Y	0.23
LUAD	chr4	168511670	Missense_Mutation	novel	E56K	0.16
LUAD	chr4	168512048	Missense_Mutation	NA	I182V	0.25
LUAD	chr4	168512038	Missense_Mutation	novel	E178D	0.1
LUAD	chr4	168512252	Missense_Mutation	novel	A250T	0.13
LUAD	chr4	168512137	Silent	novel	P211P	0.29
LUAD	chr4	168511934	Missense_Mutation	NA	G144R	0.43
LUAD	chr4	168668331	Missense_Mutation	NA	S350R	0.13
LUAD	chr4	168711868	Missense_Mutation	NA	A637S	0.13
LUAD	chr4	168925069	Missense_Mutation	NA	D1117H	0.16
LUAD	chr4	168681396	Splice_Region	rs774645499	P384P	0.22
LUAD	chr4	168668270	Missense_Mutation	NA	I330N	0.49
LUAD	chr4	168925032	Missense_Mutation	NA	K1104N	0.18
LUAD	chr4	168685506	Missense_Mutation	NA	L428I	0.35
LUAD	chr4	168711746	Missense_Mutation	NA	R596K	0.4
LUAD	chr4	168690626	Silent	rs766551069	A453A	0.28
LUAD	chr4	168711678	Silent	novel	S573S	0.14
LUAD	chr4	168685560	Splice_Site	rs756057934	X445_splice	0.14
LUAD	chr4	168512284	Missense_Mutation	novel	Q260H	0.12
LUAD	chr4	168711695	Missense_Mutation	novel	K579R	0.45
LUAD	chr4	168690675	Silent	NA	L470L	0.12
LUAD	chr4	168512242	Missense_Mutation	novel	N246K	0.46
LUAD	chr4	168681381	Silent	novel	R379R	0.47
LUSC	chr4	168511931	Missense_Mutation	novel	R143S	0.23
LUSC	chr4	168890940	Silent	NA	A661A	0.13
LUSC	chr4	168511916	Nonsense_Mutation	rs201653170	R138*	0.25
LUSC	chr4	168921644	Silent	novel	I987I	0.21
LUSC	chr4	168511691	Missense_Mutation	novel	E63Q	0.21
LUSC	chr4	168913935	Silent	NA	I877I	0.24
LUSC	chr4	168891057	Frame_Shift_Ins	novel	*R710Qfs16**	0.24
LUSC	chr4	168913932	Silent	novel	R876R	0.55
OV	chr4	168903804	Silent	NA	H840H	0.42
OV	chr4	168683068	Missense_Mutation	novel	A409T	0.04
OV	chr4	168511766	Missense_Mutation	NA	E88K	0.27
OV	chr4	168512358	In_Frame_Ins	novel	G285_S286insFLLSSARK	0.07
OV	chr4	168681383	Missense_Mutation	NA	A380G	0.23
OV	chr4	168512298	Missense_Mutation	novel	L265H	0.07
PAAD	chr4	168915900	Missense_Mutation	rs114171764	R908H	0.3
PRAD	chr4	168916008	Missense_Mutation	novel	L944R	0.22
PRAD	chr4	168512220	Missense_Mutation	novel	A239V	0.31
PRAD	chr4	168690615	Missense_Mutation	novel	T450A	0.38
READ	chr4	168511843	Silent	NA	I113I	0.25
READ	chr4	168913948	Missense_Mutation	rs758884211	R882W	0.11
READ	chr4	168925058	Missense_Mutation	novel	T1113I	0.25
READ	chr4	168925061	Missense_Mutation	NA	A1114V	0.2
READ	chr4	168711851	Missense_Mutation	novel	K631T	0.39
READ	chr4	168891022	Missense_Mutation	NA	R689C	0.41
SARC	chr4	168926519	3'Flank	novel		1
SARC	chr4	168683068	Missense_Mutation	novel	A409S	0.14
SARC	chr4	168925060	Missense_Mutation	novel	A1114S	0.1
SKCM	chr4	168690659	Silent	NA	V464V	0.4
SKCM	chr4	168512110	Missense_Mutation	novel	S202R	0.41
SKCM	chr4	168711730	Missense_Mutation	rs772476893	E591K	0.31
SKCM	chr4	168690626	Silent	rs766551069	A453A	0.67
SKCM	chr4	168891014	Missense_Mutation	NA	R686Q	0.56
SKCM	chr4	168512187	Missense_Mutation	novel	G228E	0.22
SKCM	chr4	168512188	Silent	novel	G228G	0.22
SKCM	chr4	168668238	Silent	NA	I319I	0.35
SKCM	chr4	168890970	Silent	NA	E671E	0.15
SKCM	chr4	168711902	Missense_Mutation	rs201034052	P648L	0.14
SKCM	chr4	168668322	Silent	rs755672194	T347T	0.44
SKCM	chr4	168668193	Nonsense_Mutation	novel	W304*	0.36
SKCM	chr4	168511750	Silent	NA	K82K	0.17
SKCM	chr4	168711736	Missense_Mutation	NA	G593S	0.39
SKCM	chr4	168891004	Missense_Mutation	NA	D683N	0.31
SKCM	chr4	168898664	Missense_Mutation	NA	G808R	0.19
SKCM	chr4	168925262	3'UTR	novel		0.29
SKCM	chr4	168891014	Missense_Mutation	NA	R686Q	0.54
SKCM	chr4	168924988	Missense_Mutation	NA	G1090R	0.3
SKCM	chr4	168683035	Missense_Mutation	NA	G398R	0.22
SKCM	chr4	168668249	Missense_Mutation	NA	G323E	0.47
SKCM	chr4	168709040	Missense_Mutation	rs751116198	T505I	0.12
SKCM	chr4	168512123	Missense_Mutation	novel	P207S	0.14
SKCM	chr4	168924987	Missense_Mutation	NA	Q1089H	0.75
SKCM	chr4	168890965	Missense_Mutation	rs767729090	D670N	0.2
SKCM	chr4	168711582	Splice_Region	novel	A541A	0.07
SKCM	chr4	168511947	Missense_Mutation	NA	P148L	0.29
SKCM	chr4	168711747	Silent	rs763763366	R596R	0.48
SKCM	chr4	168691292	Missense_Mutation	NA	E501K	0.27
SKCM	chr4	168512390	Missense_Mutation	novel	G296R	0.33
SKCM	chr4	168711666	Silent	NA	L569L	0.33
SKCM	chr4	168894598	Missense_Mutation	NA	R707K	0.43
SKCM	chr4	168711812	Missense_Mutation	NA	G618E	0.15
SKCM	chr4	168903876	Silent	NA	G864G	0.17
SKCM	chr4	168894591	Missense_Mutation	rs748036704	E705K	0.45
SKCM	chr4	168890940	Silent	NA	A661A	0.46
SKCM	chr4	168511881	Missense_Mutation	NA	P126L	0.13
SKCM	chr4	168711783	Silent	novel	R608R	0.23
SKCM	chr4	168511716	Missense_Mutation	novel	S71F	0.55
SKCM	chr4	168915924	Missense_Mutation	novel	D916V	0.25
SKCM	chr4	168915925	Silent	rs143544548	D916D	0.25
SKCM	chr4	168924306	Missense_Mutation	novel	G1037E	0.16
SKCM	chr4	168915926	Missense_Mutation	rs372708613	E917K	0.34
SKCM	chr4	168711802	Missense_Mutation	NA	P615S	0.4
SKCM	chr4	168690627	Missense_Mutation	NA	E454K	0.63
SKCM	chr4	168711600	Silent	novel	S547S	0.18
SKCM	chr4	168711794	Missense_Mutation	NA	G612E	0.2
SKCM	chr4	168511482	5'UTR	novel		0.38
SKCM	chr4	168915926	Missense_Mutation	rs372708613	E917K	0.66
SKCM	chr4	168711677	Missense_Mutation	NA	S573F	0.26
STAD	chr4	168512126	Frame_Shift_Del	novel	*N209Ifs7**	0.08
STAD	chr4	168512322	Missense_Mutation	NA	F273S	0.22
STAD	chr4	168890968	Nonsense_Mutation	NA	E671*	0.3
STAD	chr4	168921741	Frame_Shift_Ins	novel	*V1028Lfs55**	0.28
STAD	chr4	168511719	Missense_Mutation	novel	P72H	0.4
STAD	chr4	168511972	Silent	rs146108255	T156T	0.21
STAD	chr4	168512267	Missense_Mutation	rs778216620	R255C	0.24
STAD	chr4	168890993	Missense_Mutation	novel	A679V	0.14
STAD	chr4	168683002	Frame_Shift_Ins	novel	*K389Efs44**	0.13
STAD	chr4	168924354	Missense_Mutation	NA	V1053A	0.14
STAD	chr4	168511949	Missense_Mutation	NA	S149G	0.3
UCEC	chr4	168711789	Silent	NA	T610T	0.41
UCEC	chr4	168511444	5'UTR	novel		0.7
UCEC	chr4	168924341	Missense_Mutation	rs548068667	R1049C	0.41
UCEC	chr4	168891033	Silent	novel	E692E	0.45
UCEC	chr4	168927967	3'Flank	novel		0.33
UCEC	chr4	168921700	Missense_Mutation	rs777057820	R1006Q	0.49
UCEC	chr4	168668209	Nonsense_Mutation	novel	E310*	0.4
UCEC	chr4	168913981	Nonsense_Mutation	novel	R893*	0.33
UCEC	chr4	168927847	3'Flank	novel		0.1
UCEC	chr4	168927800	3'Flank	novel		0.19
UCEC	chr4	168927934	3'Flank	novel		0.27
UCEC	chr4	168711850	Missense_Mutation	NA	K631Q	0.1
UCEC	chr4	168511806	Missense_Mutation	NA	P101H	0.33
UCEC	chr4	168921618	Missense_Mutation	rs367575623	R979C	0.46
UCEC	chr4	168668322	Silent	rs755672194	T347T	0.4
UCEC	chr4	168711630	Silent	novel	D557D	0.22
UCEC	chr4	168898470	Intron	novel		0.16
UCEC	chr4	168926882	3'Flank	novel		0.59
UCEC	chr4	168511644	Missense_Mutation	rs372582436	R47Q	0.1
UCEC	chr4	168927002	3'Flank	novel		0.16
UCEC	chr4	168668327	Missense_Mutation	NA	P349L	0.06
UCEC	chr4	168927002	3'Flank	novel		0.27
UCEC	chr4	168927214	3'Flank	novel		0.12
UCEC	chr4	168668303	Missense_Mutation	rs142010058	R341H	0.4
UCEC	chr4	168927969	3'Flank	novel		0.33
UCEC	chr4	168890964	Silent	rs561075148	S669S	0.39
UCEC	chr4	168926315	3'Flank	novel		0.21
UCEC	chr4	168926664	3'Flank	novel		0.31
UCEC	chr4	168927229	3'Flank	novel		0.16
UCEC	chr4	168894766	Intron	NA		0.34
UCEC	chr4	168927980	3'Flank	novel		0.32
UCEC	chr4	168921700	Missense_Mutation	rs777057820	R1006Q	0.17
UCEC	chr4	168921626	Silent	rs775868002	N981N	0.32
UCEC	chr4	168921712	Missense_Mutation	novel	N1010S	0.29
UCEC	chr4	168711832	Missense_Mutation	novel	G625C	0.07
UCEC	chr4	168890982	Silent	novel	G675G	0.11
UCEC	chr4	168668257	Missense_Mutation	NA	L326I	0.37
UCEC	chr4	168926512	3'Flank	novel		0.36
UCEC	chr4	168926942	3'Flank	novel		0.39
UCEC	chr4	168891023	Missense_Mutation	rs758090588	R689H	0.27
UCEC	chr4	168891014	Missense_Mutation	NA	R686Q	0.33
UCEC	chr4	168898478	Intron	novel		0.2
UCEC	chr4	168928010	3'Flank	novel		0.51
UCEC	chr4	168928426	3'Flank	novel		0.46
UCEC	chr4	168928344	3'Flank	novel		0.17
UCEC	chr4	168927980	3'Flank	novel		0.32
UCEC	chr4	168511759	Missense_Mutation	NA	K85N	0.35
UCEC	chr4	168903895	Missense_Mutation	novel	A871T	0.09
UCEC	chr4	168914004	Silent	NA	G900G	0.33
UCEC	chr4	168685530	Missense_Mutation	novel	T436A	0.37
UCEC	chr4	168668333	Missense_Mutation	novel	G351D	0.06
UCEC	chr4	168898715	Splice_Site	novel	X824_splice	0.38
UCEC	chr4	168511789	Missense_Mutation	novel	Q95H	0.33
UCEC	chr4	168926246	3'UTR	novel		0.33
UCEC	chr4	168711773	Missense_Mutation	NA	A605V	0.45
UCEC	chr4	168915926	Missense_Mutation	rs372708613	E917K	0.52
UCEC	chr4	168685513	Missense_Mutation	rs145571230	R430Q	0.41
UCEC	chr4	168711696	Missense_Mutation	novel	K579N	0.34
UCEC	chr4	168877784	Intron	novel		0.48
UCEC	chr4	168894590	Silent	rs372414187	Y704Y	0.24
UCEC	chr4	168925007	Missense_Mutation	novel	A1096V	0.04
UCEC	chr4	168921599	Silent	rs566543059	S972S	0.42
UCEC	chr4	168691294	Splice_Site	novel	X501_splice	0.33
UCEC	chr4	168709051	Missense_Mutation	rs145026144	A509T	0.27
UCEC	chr4	168891006	Silent	novel	D683D	0.31
UCEC	chr4	168927842	3'Flank	novel		0.53
UCEC	chr4	168927300	3'Flank	novel		0.38
UCEC	chr4	168927814	3'Flank	novel		0.42
UCS	chr4	168894735	Intron	novel		0.25
UCS	chr4	168903884	Missense_Mutation	novel	T867I	0.44

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.1444	2.13e-13
DLBC	DEL	0.1042	0.037264
KIRC	DEL	0.108	0.0008848
MESO	DEL	0.3793	0.10007
PAAD	DEL	0.0978	0.027407
PCPG	DEL	0.0741	0.003794
THCA	DEL	0.006	0.065321

Survival Analysis

Cancer	P-value	Q-value
THYM	0.026	Kaplan-Meier Survival Analysis
KIRC	0.026	Kaplan-Meier Survival Analysis
MESO	0.00043	Kaplan-Meier Survival Analysis
ACC	0.012	Kaplan-Meier Survival Analysis
SKCM	0.0037	Kaplan-Meier Survival Analysis
BLCA	0.00022	Kaplan-Meier Survival Analysis
UCEC	0.00044	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
LUAD	0.0054	Kaplan-Meier Survival Analysis
OV	0.048	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742